CN104306520A - Traditional Chinese medicine veterinary medicine oral liquid for treating Newcastle disease and preparation method of traditional Chinese medicine veterinary medicine oral liquid - Google Patents
Traditional Chinese medicine veterinary medicine oral liquid for treating Newcastle disease and preparation method of traditional Chinese medicine veterinary medicine oral liquid Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine veterinary medicine oral liquid for treating Newcastle disease. The oral liquid is prepared from the following components in parts by weight: 4-8 parts of hemianthus micranthemoides, 4-8 parts of mosladianthera, 2-6 parts of honeysuckle, 1-5 parts of fructus forsythia, 3-7 parts of isatis root, 2-6 parts of folium isatidis, 4-8 parts of indigo naturalis, 1-5 parts of liquorice and 1-5 parts of houttuynia cordata. The traditional Chinese medicine veterinary medicine oral liquid is a pure traditional Chinese medicine preparation without toxic or side effects, and is safe and reliable to use without drug residue or social harms. The traditional Chinese medicine veterinary medicine oral liquid is mainly used for treating the Newcastle disease caused by viruses and also has good curative effects on diseases caused by bacteria and viruses, such as chicken colibacillosis, pullorum disease, avian influenza and cholera fowl.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Traditional Chinese veterinary medicine oral solution for the treatment of newcastle and preparation method thereof.
Background technology
The Causative virus Avian pneumo-encephalitis virus of newcastle is the avian paramyxovirus I type of paramyxovirus section fowl Rubulavirus.Virus is present in all histoorgans of disease fowl, body fluid, secretions and excretion, the highest with brain, spleen, lung toxic amount, the longest with the bone marrow toxic time.Resistance is strong under cryogenic, can survive 1 ~ 2 year at 4 DEG C, when-20 DEG C more than energy Survival for 10 Years; Vacuum freeze-drying virus can preserve 30 days at 30 DEG C, can preserve 230 days for 15 DEG C; The stability of different strains to heat has larger difference.This virus is not strong to disinfectant, daylight and high temperature resistance, the typical concentrations of general disinfectant can be killed very soon, a variety of factor can affect the effect of disinfectant, as the kind of the quantity of virus, strain, temperature, humidity, sunlight irradiate, storage requirement and whether there is Organic substance etc., especially maximum with the influence of organic existence and low temperature.Avian pneumo-encephalitis virus can be passed through digestive tract or respiratory tract, also can invade body through eye conjunctiva, injured skin and cloaca mucosa, and virus is very fast in infestation position breeding in 24h, enters blood subsequently and is diffused into whole body, cause viremia.Now viruses adsorption is on cell, makes red cell agglutination, expands, then haemolysis occurs.Virus also makes heart, vascular system generation grievous injury simultaneously, causes muscular degeneration of heart and heart failure occurs, thus causing blood circulation height barrier.Due to capillary permeability gangrenous inflammation, thus face and examine the serious gastricism of performance and dysentery.Then mainly there is catarrhal inflammation and hemorrhage at respiratory tract, make trachea by the mucus plugging of oozing out, cause height dyspnea.In the later stage of disease, Virus entry central nervous system, often causes apyetous encephalitis to change, causes nervous symptoms.Chicken group is once import newcastle into, and cause crushing popular, M & M can reach more than 90%.Newcastle is one of epidemic disease that harm home poultry raising industry is the most serious.
Summary of the invention
The object of the present invention is to provide a kind of Traditional Chinese veterinary medicine oral solution for the treatment of newcastle, this oral liquid pure Chinese medicinal preparation, has no side effect, safe and reliable, can not produce drug residue and social effects of pollution.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Traditional Chinese veterinary medicine oral solution of newcastle.
The present invention is achieved through the following technical solutions:
Treat a Traditional Chinese veterinary medicine oral solution for newcastle, component and the ratio of weight and number thereof of its oral liquid are respectively: Herba Phyllanthi Urinariae 4-8 part; Miliaria grass 4-8 part; Flos Lonicerae 2-6 part; Fructus Forsythiae 1-5 part; Radix Isatidis 3-7 part; Folium Isatidis 2-6 part; Indigo Naturalis 4-8 part; Radix Glycyrrhizae 1-5 part; Herba Houttuyniae 1-5 part.
And component and the optimum ratio of weight and number thereof of this oral liquid are respectively: Herba Phyllanthi Urinariae 6 parts; Miliaria grass 6 parts; Flos Lonicerae 4 parts; Fructus Forsythiae 3 parts; Radix Isatidis 5 parts; Folium Isatidis 4 parts; Indigo Naturalis 6 parts; 3 parts, Radix Glycyrrhizae; Herba Houttuyniae 3 parts.
Treat a preparation method for the Traditional Chinese veterinary medicine oral solution of newcastle, its preparation methods steps is:
(1) Herba Phyllanthi Urinariae, miliaria grass, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Folium Isatidis, Indigo Naturalis, Radix Glycyrrhizae, Herba Houttuyniae is taken by proportioning weight, the drinking water adding 10 times of inventorys is dropped in Chinese medicine extracting tank through cleaning after demulcen is dried, at room temperature soak after 2 hours, be heated to water boiling decoction 2 hours, will suck in extracting solution storage tank after extracting liquid filtering;
(2) add the drinking water of 7 times of inventorys in Chinese medicine extracting tank again, be heated to boiling decoction and will suck extracting solution storage tank after extracting liquid filtering in 1 hour, and first time extracting solution merging;
(3) extracting solution enter from extracting solution storage tank I, II single-effect evaporator to mesoscope 2/3 only, heat with steam pressure 0.09Mpa, and feed supplement is in time to normal level.Double effect evaporator 15 minutes discharge condensed waters once, every two hours discharge the condensation vapour of heater once;
(4), when extracting solution is concentrated into 1/2 of visor under I, II single-effect evaporator, in imitating II, extracting solution proceeds in I effect concentrated, when in I single-effect evaporator, extracting solution is concentrated into 1/2 of lower visor, is sucked by extracting solution in Alcohol-settling tank, and Indoor Natural cools;
(5) open vacuum pump, it is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, fully stirs and makes its extracting solution alcohol content be 55%, leave standstill 24 hours, will suck supernatant storage after supernatant liquid filtering in Alcohol-settling tank; It is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, and after fully stirring makes its first time suck supernatant, remaining precipitate alcohol content is 75%, leaves standstill 24 hours, will suck supernatant storage tank and first time supernatant merging after supernatant liquid filtering in Alcohol-settling tank; It is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, after abundant stirring makes its second time suck supernatant, remaining precipitate alcohol content is 83%, leave standstill 24 hours, by sucking supernatant storage tank and first and second supernatant merging after supernatant liquid filtering in Alcohol-settling tank, discard remaining precipitate in Alcohol-settling tank;
(6) spherical concentration tank is sucked by after the extracting liquid filtering in supernatant storage tank, open Steam Heating, steam pressure should control at < 0.1Mpa, and open condensing hot air furnace condensed fluid, when condensed fluid measurement alcohol content is < 10%, stop collecting, extracting solution continues concentrated, to condensed fluid without shut-down operation during alcohol taste;
(7) the extracting solution Indoor Natural cooling in concentration tank, be cooled to room temperature, under 4-8 DEG C of condition, cold preservation is for subsequent use;
(8) extracting solution adds in oral liquid Agitation Tank, adds purified water and contains crude drug in whole 2g to every milliliter, open stirring, stir, add 0.1-0.2% benzoic acid, be stirred to and dissolve completely, filter, the Traditional Chinese veterinary medicine oral solution of the newcastle that can obtain medical treatment.
Advantage of the present invention and beneficial effect are:
1. oral liquid is pure Chinese medicinal preparation, has no side effect, safe and reliable, can not produce drug residue and social effects of pollution.
2. oral liquid cures mainly the newcastle caused by virus, also has good curative effect to the disease such as chicken colibacillosis, Pullorum Disease, bird flu, fowl cholera caused by antibacterial and virus.
3. crude drug of the present invention is purchased easily, cheap.
4. in whole preparation process of the present invention, the garbage produced does not pollute the environment, and is easy to process.
5. the present invention adopts the production technology of Chinese medicine extraction to produce, and has extracted middle the effective elements of the medicine to greatest extent, and the harmful substance well eliminated in Chinese medicine extraction liquid and impurity.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Treat a Traditional Chinese veterinary medicine oral solution for newcastle, the weight of this oral liquid component is respectively: Herba Phyllanthi Urinariae 60kg, miliaria grass 60kg, Flos Lonicerae 40kg, Fructus Forsythiae 30kg, Radix Isatidis 50kg, Folium Isatidis 40kg, Indigo Naturalis 60kg, Radix Glycyrrhizae 30kg, Herba Houttuyniae 30kg.
Treat a preparation method for the Traditional Chinese veterinary medicine oral solution of newcastle, this step is as follows:
(1) the clean medical material of screening is purchased, Herba Phyllanthi Urinariae, miliaria grass, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Folium Isatidis, Indigo Naturalis, Radix Glycyrrhizae, Herba Houttuyniae is taken by proportioning weight at Weighing Area, the drinking water adding 10 times of inventorys is dropped in Chinese medicine extracting tank through cleaning after demulcen is dried, at room temperature soak after 2 hours, be heated to water boiling decoction 2 hours, will suck after extracting liquid filtering in extracting solution storage tank.
(2) add the drinking water of 7 times of inventorys in Chinese medicine extracting tank again, be heated to boiling decoction and will suck extracting solution storage tank after extracting liquid filtering in 1 hour, and first time extracting solution merging.
(3) extracting solution enter from extracting solution storage tank I, II single-effect evaporator to mesoscope 2/3 only, heats and be advisable with steam pressure 0.09Mpa, and feed supplement is in time to normal level.Double effect evaporator 15 minutes discharge condensed waters once, every two hours discharge the condensation vapour of heater once.
(4), when extracting solution is concentrated into 1/2 of visor under I, II single-effect evaporator, in imitating II, extracting solution proceeds in I effect concentrated, when in I single-effect evaporator, extracting solution is concentrated into 1/2 of lower visor, is sucked by extracting solution in Alcohol-settling tank, and Indoor Natural cools.
(5) 1. open vacuum pump, it is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, fully stirs and makes its extracting solution alcohol content be 55%, leave standstill 24 hours, will suck supernatant storage after supernatant liquid filtering in Alcohol-settling tank.2. Alcohol-settling tank sucks alcohol content is the dehydrated alcohol of more than 95%, and fully stirring remaining precipitate alcohol content after making its first time suck supernatant is 75%, leaves standstill 24 hours, will suck supernatant storage tank after supernatant liquid filtering in Alcohol-settling tank.Merge with first time supernatant.3. Alcohol-settling tank sucks alcohol content is the dehydrated alcohol of more than 95%, and fully stirring remaining precipitate alcohol content after making its second time suck supernatant is 83%, leaves standstill 24 hours, will suck supernatant storage tank after supernatant liquid filtering in Alcohol-settling tank.Merge with first and second supernatant, discard remaining precipitate in Alcohol-settling tank.
(6) spherical concentration tank is sucked by after the extracting liquid filtering in supernatant storage tank, open Steam Heating, steam pressure should control at < 0.1Mpa, and open condensing hot air furnace condensed fluid (dehydrated alcohol), when condensed fluid measurement alcohol content is < 10%, stop collecting, extracting solution continues concentrated, to condensed fluid without shut-down operation during alcohol taste.
(7) the extracting solution Indoor Natural cooling in concentration tank, be cooled to room temperature, under 4-8 DEG C of condition, cold preservation is for subsequent use.
(8) extracting solution adds in oral liquid Agitation Tank, adds purified water and contains crude drug in whole 2g to every milliliter, open stirring, stir, add 0.1-0.2% benzoic acid, be stirred to and dissolve completely, filter, fill, packaging, the Traditional Chinese veterinary medicine oral solution of the newcastle that can obtain medical treatment.
Embodiment 2
Treat a Traditional Chinese veterinary medicine oral solution for newcastle, the weight of this oral liquid component is respectively: Herba Phyllanthi Urinariae 50kg, miliaria grass 50kg, Flos Lonicerae 30kg, Fructus Forsythiae 20kg, Radix Isatidis 40kg, Folium Isatidis 30kg, Indigo Naturalis 50kg, Radix Glycyrrhizae 20kg, Herba Houttuyniae 20kg.
The step of its preparation technology is with embodiment 1.
Embodiment 3.
Treat a Traditional Chinese veterinary medicine oral solution for newcastle, the weight of this oral liquid component is respectively: Herba Phyllanthi Urinariae 40kg, miliaria grass 40kg, Flos Lonicerae 20kg, Fructus Forsythiae 10kg, Radix Isatidis 30kg, Folium Isatidis 20kg, Indigo Naturalis 40kg, Radix Glycyrrhizae 10kg, Herba Houttuyniae 10kg.
The step of its preparation technology is with embodiment 1.
Embodiment 4.
Treat a Traditional Chinese veterinary medicine oral solution for newcastle, the weight of this oral liquid component is respectively: Herba Phyllanthi Urinariae 70kg, miliaria grass 70kg, Flos Lonicerae 50kg, Fructus Forsythiae 40kg, Radix Isatidis 60kg, Folium Isatidis 50kg, Indigo Naturalis 70kg, Radix Glycyrrhizae 40kg, Herba Houttuyniae 40kg.
The step of its preparation technology is with embodiment 1.
Embodiment 5.
Treat a Traditional Chinese veterinary medicine oral solution for newcastle, the weight of this oral liquid component is respectively: Herba Phyllanthi Urinariae 80kg, miliaria grass 80kg, Flos Lonicerae 60kg, Fructus Forsythiae 50kg, Radix Isatidis 70kg, Folium Isatidis 60kg, Indigo Naturalis 80kg, Radix Glycyrrhizae 50kg, Herba Houttuyniae 50kg.
The step of its preparation technology is with embodiment 1.
Clinical trial
The usage and dosage of oral liquid: every 250ml can be watered 200kg, sooner or later concentrates drinking-water each once, is used in conjunction 3-5 day.
In April, 2014 starts clinical trial:
Select spiritedness dispirited, to search for food minimizing, drinking-water increases, dyspnea, turn neck, hope star, astasia, do not rise sleepingly, larynx and tracheal mucosa hyperemia or hemorrhage, there is mucus, " rumble " sound, row's yellow green loose stool, Egg Production of Laying Hens reduces or stops production, soft-preserved egg, fade egg, husky shell egg, abnormal-shape egg, follicle is out of shape, the follicle congestion of blood vessel or hemorrhage, glandular stomach thelorrhagia, intestinal has the chicken 2000 of the symptoms such as the hemorrhage or necrosis region of Semen Jujubae shape aubergine, test period: 7 days, test determination: 2000 fowl raisings are in the environment not contacting any medicine, the feedstuff of feeding not containing any medicine and additive, feed 2 days.3rd day starts to be divided into 4 groups, and often organize 500 (space out between group and group, do not spread disease mutually), feeding environment is the same with first 2 days with the condition of feeding.Clinical trial starts to organize into groups medication on the 3rd day, and 1. matched group need not any medicine 2. test group of the present invention 1 and test group 2 use oral liquid treatment 3. conventional therapy group of the present invention Therapeutic Method conveniently to treat.
Result of the test is as follows:
Test shows: test group medication first day therapeutic effect is obvious, medication after 5 days cure rate reach 99.00%, conventional therapy group medication first day therapeutic effect is not too obvious, medication after 5 days cure rate only reach 68.80%.Illustrate that oral liquid of the present invention has special effect to the newcastle that virus causes by test, also have good curative effect to the disease such as chicken colibacillosis, Pullorum Disease, bird flu, fowl cholera caused by antibacterial and virus.
Claims (3)
1. treat a Traditional Chinese veterinary medicine oral solution for newcastle, it is characterized in that: component and the ratio of weight and number thereof of this oral liquid are respectively: Herba Phyllanthi Urinariae 4-8 part; Miliaria grass 4-8 part; Flos Lonicerae 2-6 part; Fructus Forsythiae 1-5 part; Radix Isatidis 3-7 part; Folium Isatidis 2-6 part; Indigo Naturalis 4-8 part; Radix Glycyrrhizae 1-5 part; Herba Houttuyniae 1-5 part.
2. the Traditional Chinese veterinary medicine oral solution for the treatment of newcastle according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this oral liquid are respectively: Herba Phyllanthi Urinariae 6 parts; Miliaria grass 6 parts; Flos Lonicerae 4 parts; Fructus Forsythiae 3 parts; Radix Isatidis 5 parts; Folium Isatidis 4 parts; Indigo Naturalis 6 parts; 3 parts, Radix Glycyrrhizae; Herba Houttuyniae 3 parts.
3. a preparation method for the Traditional Chinese veterinary medicine oral solution for the treatment of newcastle as claimed in claim 1, is characterized in that: this preparation method step is:
(1) Herba Phyllanthi Urinariae, miliaria grass, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Folium Isatidis, Indigo Naturalis, Radix Glycyrrhizae, Herba Houttuyniae is taken by proportioning weight, the drinking water adding 10 times of inventorys is dropped in Chinese medicine extracting tank through cleaning after demulcen is dried, at room temperature soak after 2 hours, be heated to water boiling decoction 2 hours, will suck in extracting solution storage tank after extracting liquid filtering;
(2) add the drinking water of 7 times of inventorys in Chinese medicine extracting tank again, be heated to boiling decoction and will suck extracting solution storage tank after extracting liquid filtering in 1 hour, and first time extracting solution merging;
(3) extracting solution enter from extracting solution storage tank I, II single-effect evaporator to mesoscope 2/3 only, heating is with steam pressure 0.09Mpa, and feed supplement is in time to normal level, double effect evaporator 15 minutes discharge condensed waters once, every two hours discharge the condensation vapour of heater once;
(4), when extracting solution is concentrated into 1/2 of visor under I, II single-effect evaporator, in imitating II, extracting solution proceeds in I effect concentrated, when in I single-effect evaporator, extracting solution is concentrated into 1/2 of lower visor, is sucked by extracting solution in Alcohol-settling tank, and Indoor Natural cools;
(5) open vacuum pump, it is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, fully stirs and makes its extracting solution alcohol content be 55%, leave standstill 24 hours, will suck supernatant storage after supernatant liquid filtering in Alcohol-settling tank; It is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, and after fully stirring makes its first time suck supernatant, remaining precipitate alcohol content is 75%, leaves standstill 24 hours, will suck supernatant storage tank and first time supernatant merging after supernatant liquid filtering in Alcohol-settling tank; It is the dehydrated alcohol of more than 95% that Alcohol-settling tank sucks alcohol content, after abundant stirring makes its second time suck supernatant, remaining precipitate alcohol content is 83%, leave standstill 24 hours, by sucking supernatant storage tank and first and second supernatant merging after supernatant liquid filtering in Alcohol-settling tank, discard remaining precipitate in Alcohol-settling tank;
(6) spherical concentration tank is sucked by after the extracting liquid filtering in supernatant storage tank, open Steam Heating, steam pressure should control at < 0.1Mpa, and open condensing hot air furnace condensed fluid, when condensed fluid measurement alcohol content is < 10%, stop collecting, extracting solution continues concentrated, to condensed fluid without shut-down operation during alcohol taste;
(7) the extracting solution Indoor Natural cooling in concentration tank, be cooled to room temperature, under 4-8 DEG C of condition, cold preservation is for subsequent use;
(8) extracting solution adds in oral liquid Agitation Tank, adds purified water and contains crude drug in whole 2g to every milliliter, open stirring, stir, add 0.1-0.2% benzoic acid, be stirred to and dissolve completely, filter, the Traditional Chinese veterinary medicine oral solution of the newcastle that can obtain medical treatment.
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| CN108308448A (en) * | 2018-03-30 | 2018-07-24 | 广西万寿谷投资集团股份有限公司 | Application of the Common Leafflower Herb in preparing the feed addictive for preventing avian influenza |
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| CN108653486A (en) * | 2017-03-29 | 2018-10-16 | 天津市佳禾蛋鸡养殖有限公司 | Prevent the chicken medication of avian cholera bird flu |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905017A (en) * | 2015-05-22 | 2015-09-16 | 贵港市桂田黄沙鳖种苗场 | Feed additive for preventing and treating parotitis of truogx sinensis |
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| CN106177110A (en) * | 2016-07-31 | 2016-12-07 | 台江县大营家禽生态养殖农民专业合作社 | A kind of Chinese medicine preparation preventing and treating epidemic diarrhea of laying hen |
| CN108653486A (en) * | 2017-03-29 | 2018-10-16 | 天津市佳禾蛋鸡养殖有限公司 | Prevent the chicken medication of avian cholera bird flu |
| CN108308448A (en) * | 2018-03-30 | 2018-07-24 | 广西万寿谷投资集团股份有限公司 | Application of the Common Leafflower Herb in preparing the feed addictive for preventing avian influenza |
| CN108617882A (en) * | 2018-05-15 | 2018-10-09 | 广西万寿谷投资集团股份有限公司 | A kind of chicken feed addictive of anti-pestilence and preparation method thereof |
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