CN109432199A - A kind of Chinese medicine composition and preparation method thereof for treating acute cough - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating acute cough Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating acute cough.The Chinese medicine composition of the treatment acute cough, raw material includes honeysuckle, semen armeniacae amarae, Fructus Forsythiae.Inventive formulation is scientific and reasonable, configuration is simple, it has no toxic side effect, the virus that the Chinese medicine composition of final treatment acute cough obtained can dredge respiratory tract, remove lung, cure mainly the disease with cough symptom, and have the air flue channels and collaterals effect of dredging lung, it can be applied to treat sense, tracheitis, bronchitis, pneumonia, asthma, acute laryngitis, repeated respiratory infections, morbilli, rubeola and sixth disease etc..
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating acute cough and its preparation side
Method.
Background technique
Cough is one of cardinal symptom of respiratory disease, and cough is by trachea-bronchial epithelial cell mucous membrane or pleura by inflammation, different
Object, physically or chemically sexual stimulus causes, and Closure states of glottis, respiratory muscle are shunk before this when cough, and intrapulmonic pressure increases, then glottis
It opens, pulmonary air is spouting.It coughs and is known as expectoration with collected liquid expectoration.Men and women, old and young at all seasons in all have can
This disease can be suffered from, disease incidence is high, and if eradicated not in time, and cough does not stop, and switchs to chronic usually bring to patient by acute
Bigger pain, such as uncomfortable in chest, pharynx itch, breathe, and rest sleep is influenced symptom does not aggravate.Currently, doctor trained in Western medicine is relieving cough and reducing sputum
Common medicine have ammonium chloride, bromhexine, carbocisteine, for inhibiting short-term abundant expectoration symptom that there is significant curative effect, but
It can not effective cough-relieving apophlegmatic.And Western medicine mostly with anti-inflammatory and is equipped with antibiotics and treats, but side effect is bigger,
Especially antibiotic, the abuse of antibiotic will cause more serious drug resistance, cough caused by some bronchitis of going slowly
Antibiotic treatment should not be used for a long time.In contrast, traditional Chinese medicine has huge advantage.Chinese medicine thinks that cough is by six external factors which cause diseases exopathogen
Invade lung system or visceral dysfunction, inside injure lung, lung qi is unclear, lose in declare respectful institute at.Therefore a point card opinion is controlled and is divided into cough outside
Sense cough and endogenous cough's two major classes, are also subdivided into wind-cold affecting lung, wind-heat affecting lung, wind-dryness for exogenous cough by clinical symptoms difference
Hurt 3 class of lung, endogenous cough is subdivided into phlegm dampness in lungs, the strongly fragrant lung of phlegm heat, liver-fire attacking lung, 4 class of lung yin loss.Statistics discovery, lung yin lose
Empty class accounts for 22.5% in chronic cough, but yin tonics only accounts for 6% in the common recipe for the treatment of cough, however, current city
The antitussive Chinese drug sold is concentrated mainly on that the criminal's of cold lung class is in the majority with antibechic, eliminating the phlegm, clear feeding lung stomach, fluid dryness Chinese patent drug compared with
It is few.And existing mostly traditional decoction of medicinal ingredients effective to the cough of lung yin virtual loss class, it is not easy to control that there are quality, and safety, curative effect cannot get
Guarantee, be not easy to store, taking dose it is big, the disadvantages of patient medication poor compliance, therefore, it is dry to develop new treatment lung yin virtual loss class
The Chinese patent drug of cough is particularly important to clinical application is met.
Especially acute cough in children and children's having indigestion has very big relationship, and children's product can be removed in our this invention
Food alleviates the cough of children quickly.The maximum ability application that reduces children's antibiotic hormone to the greatest extent, especially infusion to child with
The harm come.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, the present invention provides a kind of Chinese medicine compositions for treating acute cough
And preparation method thereof.
A kind of Chinese medicine composition for treating acute cough, raw material include honeysuckle, semen armeniacae amarae, Fructus Forsythiae.
Specifically, in parts by mass, raw material includes honeysuckle 20-40 to the Chinese medicine composition of the treatment acute cough
Part, 10-20 parts of semen armeniacae amarae, 10-20 parts of Fructus Forsythiae.
Preferably, the Chinese medicine composition of the treatment acute cough, raw material further include that basil fruit, semen coicis, serum are big
One of halberd is a variety of.
It is highly preferred that the Chinese medicine composition of the treatment acute cough is in parts by mass, raw material further includes basil fruit 5-
15 parts, 5-15 parts of semen coicis, 5-15 parts of Euphorbia esula L.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, is first placed at 50-60 DEG C dry 1-5h, is then crushed to 30-60 with medicinal herb grinder
Mesh obtains herb powder；
The water of 5-15 times of herb powder quality is added into herb powder by III, impregnates 1-4h at 45-52 DEG C, is soaked
Liquid is steeped, is then placed at 85-100 DEG C and decocts 1-3h, filters, obtains the first decoction liquor and filter residue；
The water of 5-15 times of filter residue quality is added into above-mentioned filter residue by IV, and 1-3h is decocted at 85-100 DEG C, and filtering obtains
Second decoction liquor；
V, merges above-mentioned first, second decoction liquor, then after ultrafiltration, concentration to obtain the final product.
Preferably, the preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, is first placed at 50-60 DEG C dry 1-5h, is then crushed to 30-60 with medicinal herb grinder
Mesh obtains herb powder；
III, herb powder is added in the water of 5-15 times of herb powder quality, impregnates 1-4h at 45-52 DEG C, is soaked
Steep liquid, be subsequently added into complex enzyme, the soak, complex enzyme mass ratio be 100:(5-8), be placed at 45-52 DEG C and digest 3-
5h stirs 10-20min per hour, the first supernatant and Chinese medicine residue is obtained after centrifugation；
The water of 5-15 times of Chinese medicine mass of residue, microwave treatment 4-12min are added into above-mentioned Chinese medicine residue by IV, and centrifugation is gone
Except obtaining the second supernatant after solid residue；
V, merges above-mentioned first supernatant, the second supernatant, then after ultrafiltration, concentration to obtain the final product.
Preferably, in the preparation method of the Chinese medicine composition of the treatment acute cough, the step II are as follows: Jiang Geyuan
Material mixing is first placed at 50-60 DEG C dry 1-5h, is then crushed to 30-60 mesh with medicinal herb grinder, obtains Chinese medicine coarse powder, connect
Above-mentioned Chinese medicine coarse powder be put into ball-grinding machine grind, being milled to particle diameter is 10-50 μm, obtains herb powder.
It is highly preferred that in the preparation method of the Chinese medicine composition of the treatment acute cough, the step II are as follows: Xiang Jin
Subzero 195 DEG C-subzero 190 DEG C of liquid nitrogen is sprayed in honeysuckle flower, cool down embrittlement 2-5min, and the honeysuckle, liquid nitrogen mass ratio are (8-
12): 1, it is crushed to 30-60 mesh with medicinal herb grinder, obtains honeysuckle coarse powder；Other raw materials are placed at 50-60 DEG C dry 1-
5h is crushed to 30-60 mesh with medicinal herb grinder, and above-mentioned honeysuckle coarse powder is added, obtains Chinese medicine coarse powder, then that above-mentioned Chinese medicine is thick
Powder is put into ball-grinding machine and is ground, and being milled to particle diameter is 10-50 μm, obtains herb powder.
Preferably, in the preparation method of the Chinese medicine composition of the treatment acute cough, the step III are as follows: by Chinese medicine
Powder is added in the water of 5-15 times of herb powder quality, first impregnates 1-4h at 45-52 DEG C, obtains soak, is subsequently added into multiple
Synthase, stabilizer, the soak, complex enzyme, stabilizer mass ratio be 100:(5-8): (0.5-1.5) is placed in 45-52 DEG C
Lower enzymatic hydrolysis 3-5h stirs 10-20min per hour, the first supernatant and Chinese medicine residue is obtained after centrifugation.
The complex enzyme presses (1-3) by pectase, cellulase: the mass ratio of (2-6) forms.
The stabilizer includes one of D- trehalose, lauroyl maltoside or a variety of.
Preferably, the stabilizer presses (1-3) by D- trehalose, lauroyl maltoside: the mass ratio group of (1-3)
At.
In inventive formulation, the evacuation of honeysuckle fragrance has the function of evacuating disease and evil, is particularly good at evacuation, lung channel heat
It is evil；Fructus Forsythiae: wind and heat in the lung meridian is evacuated in resolving sputum detumescence；Almond: there is antibechic, antiasthmatic effect, and anti-inflammatory, analgesic activity can be played.
Usage of the present invention: rectally takes orally.
By adopting the above-described technical solution, compared with prior art, the present invention has the following advantages: the present invention matches
Side is scientific and reasonable, and configuration is simple, has no toxic side effect, and the Chinese medicine composition of final treatment acute cough obtained can dredge breathing
Road, the virus for removing lung, cure mainly the disease with cough symptom, and have the air flue channels and collaterals effect of dredging lung, can be applied to treat
Upper sense, tracheitis, bronchitis, pneumonia, asthma, acute laryngitis, repeated respiratory infections, morbilli, rubeola and sixth disease
Deng.
Specific embodiment
Foregoing invention content of the invention is described in further detail With reference to embodiment, but should not be incited somebody to action
This range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiments.
Each raw material and equipment introduction in embodiment:
Honeysuckle, Classification system: Lonicera japonica bears for the perennial prehensile bejuco of Caprifoliaceae
The bud in winter, kind Fengqiu is spent, and is purchased from Tongxiang City Haitai Ju Ye Co., Ltd.
Semen armeniacae amarae, Classification system: Semen Armeniacae Amarum. is the ripening fruits of rosaceous plant, the place of production
Inner Mongol, purchased from the remote Chinese medicine source producer of letter.
Fructus Forsythiae, Classification system: Forsythia suspensa (Thunb.) Vahl, the dried fruit of Oleaceae plants Fructus Forsythiae
Real, place of production Shanxi is purchased from Anguo City Jian Ren medicinal material Co., Ltd.
Basil fruit, Classification system: Ocimum basilicum L., be Lamiaceae plant sweet basil fruit, place of production Guangxi,
Purchased from Taihe County Xin Yuan crop cultivation speciality cooperative society.
Semen coicis, Classification system: Semen Coicis is the dry mature kernal of grass family coix lacryma-jobi platymiscium, kind
Pucheng Semen Coicis is purchased from Fujian Province, county magistrate road, Pucheng legendary god of farming's Semen Coicis Specialty Co-operative Organization.
Euphorbia esula L, Classification system: Euphorbia Esula Linn., the root of euphorbia plant Euphorbia esula L, place of production peace
Emblem, purchased from Bozhou City, often rich medicine company sells Co., Ltd.
D- trehalose, No. CAS: 6138-23-4, pharmaceutical grade is purchased from Tai'an Jia Ye Biotechnology Co., Ltd.
Lauroyl maltoside, No. CAS: 69227-93-6, biochemical reagents, article No. S0610 is purchased from Suzhou subfamily section
Skill limited liability company.
Pectase, enzyme activity 10000U/g are purchased from Shandong Su Kehan bioengineering limited liability company.
Cellulase, enzyme activity 20000U/g are purchased from Shandong Su Kehan bioengineering limited liability company.
The model 30B of medicinal herb grinder is purchased from Changzhou Hao Fa drying equipment Co., Ltd.
The model BY-BL200III of traditional Chinese medicine extracting machine is purchased from Henan Hua Kang hongli Medical Devices Co., Ltd..
Ball-grinding machine is MITR-YXQM-12L type nanometer formula planetary ball mill, is purchased from the limited public affairs of Changsha meter Qi instrument and equipment
Department.
Centrifugation apparatus is LW400X120 type horizontal screw centrifugal sedimentation separation machine, is purchased from Shanghai Xu Jun Machinery Co., Ltd..
Microwave equipment is LWMC-205 type power-adjustable microwave chemical reactor, is purchased from the limited duty of Nanjing Ling Jiang scientific and technological development
Ren company.
Ultrafiltration membrane, 0.01 μm of aperture, material are polyvinyl chloride, and model UF-BTR-90 is purchased from Guangzhou Te Rui water purification section
Skill Co., Ltd.
Embodiment 1
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, and first the dry 2h at 60 DEG C, is then crushed to 60 mesh with medicinal herb grinder, obtains Chinese medicine
Powder；
10 times of herb powder quality of distilled water is added into herb powder by III, first impregnates 1.5h at 50 DEG C, is soaked
Liquid is steeped, is then placed at 90 DEG C and decocts 2h, through 100 mesh filter-cloth filterings, obtain the first decoction liquor and filter residue；
10 times of filter residue quality of distilled water is added into above-mentioned filter residue by IV, decocts 2h at 90 DEG C, through 100 mesh filter cloth mistakes
Filter, obtains the second decoction liquor；
V, merges above-mentioned first, second decoction liquor, is first placed in driving pressure 0.15MPa, is used under conditions of 25 DEG C
Ultrafiltration membrane carries out ultrafiltration, and gained ultrafiltrate is then placed in temperature and is 50 DEG C, is concentrated under conditions of absolute pressure is 0.05MPa
At 25 DEG C relative density be 1.1 to get.
Embodiment 2
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, and first the dry 2h at 60 DEG C, is then crushed to 60 mesh with medicinal herb grinder, obtains Chinese medicine
Powder；
III, herb powder is added in 10 times of herb powder quality of distilled water, first impregnates 2h at 50 DEG C, is impregnated
Liquid, is subsequently added into pectase, cellulase, the soak, pectase, cellulase mass ratio be 100:2:4, be placed in 50
4h is digested at DEG C, and 10min is stirred with the revolving speed of 80r/min per hour, then is placed in 30 DEG C, is centrifuged under conditions of 2500r/min
30min obtains the first supernatant and Chinese medicine residue；
10 times of Chinese medicine mass of residue of distilled water is added in IV: Xiang Shangshu Chinese medicine residue, is in 60 DEG C, microwave power
Microwave treatment 8min under conditions of 560W, then be placed in 30 DEG C, be centrifuged 30min under conditions of 2500r/min, after removing solid residue
Obtain the second supernatant；
V, merges above-mentioned first supernatant, the second supernatant, is first placed in driving pressure 0.15MPa, under conditions of 25 DEG C
It carries out carrying out ultrafiltration using ultrafiltration membrane, gained ultrafiltrate is then placed in the condition that temperature is 50 DEG C, absolute pressure is 0.05MPa
Under be concentrated at 25 DEG C relative density be 1.1 to get.
Embodiment 3
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, and first the dry 2h at 60 DEG C, is then crushed to 60 mesh with medicinal herb grinder, obtains Chinese medicine
Powder；
III, herb powder is added in 10 times of herb powder quality of distilled water, first impregnates 2h at 50 DEG C, is impregnated
Liquid, is subsequently added into pectase, cellulase, stabilizer, the soak, pectase, cellulase, stabilizer mass ratio be
100:2:4:0.8 is placed at 50 DEG C and digests 4h, and stirs 10min per hour with the revolving speed of 80r/min, then be placed in 30 DEG C,
It is centrifuged 30min under conditions of 2500r/min, obtains the first supernatant and Chinese medicine residue；
10 times of Chinese medicine mass of residue of distilled water is added in IV: Xiang Shangshu Chinese medicine residue, is in 60 DEG C, microwave power
Microwave treatment 8min under conditions of 560W, then be placed in 30 DEG C, be centrifuged 30min under conditions of 2500r/min, after removing solid residue
Obtain the second supernatant；
V, merges above-mentioned first supernatant, the second supernatant, is first placed in driving pressure 0.15MPa, under conditions of 25 DEG C
It carries out carrying out ultrafiltration using ultrafiltration membrane, gained ultrafiltrate is then placed in the condition that temperature is 50 DEG C, absolute pressure is 0.05MPa
Under be concentrated at 25 DEG C relative density be 1.1 to get.
The stabilizer is D- trehalose.
Embodiment 4
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, and first the dry 2h at 60 DEG C, is then crushed to 60 mesh with medicinal herb grinder, obtains Chinese medicine
Powder；
III, herb powder is added in 10 times of herb powder quality of distilled water, first impregnates 2h at 50 DEG C, is impregnated
Liquid, is subsequently added into pectase, cellulase, stabilizer, the soak, pectase, cellulase, stabilizer mass ratio be
100:2:4:0.8 is placed at 50 DEG C and digests 4h, and stirs 10min per hour with the revolving speed of 80r/min, then be placed in 30 DEG C,
It is centrifuged 30min under conditions of 2500r/min, obtains the first supernatant and Chinese medicine residue；
10 times of Chinese medicine mass of residue of distilled water is added in IV: Xiang Shangshu Chinese medicine residue, is in 60 DEG C, microwave power
Microwave treatment 8min under conditions of 560W, then be placed in 30 DEG C, be centrifuged 30min under conditions of 2500r/min, after removing solid residue
Obtain the second supernatant；
V, merges above-mentioned first supernatant, the second supernatant, is first placed in driving pressure 0.15MPa, under conditions of 25 DEG C
It carries out carrying out ultrafiltration using ultrafiltration membrane, gained ultrafiltrate is then placed in the condition that temperature is 50 DEG C, absolute pressure is 0.05MPa
Under be concentrated at 25 DEG C relative density be 1.1 to get.
The stabilizer is lauroyl maltoside.
Embodiment 5
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, and first the dry 2h at 60 DEG C, is then crushed to 60 mesh with medicinal herb grinder, obtains Chinese medicine
Powder；
III, herb powder is added in 10 times of herb powder quality of distilled water, first impregnates 2h at 50 DEG C, is impregnated
Liquid, is subsequently added into pectase, cellulase, stabilizer, the soak, pectase, cellulase, stabilizer mass ratio be
100:2:4:0.8 is placed at 50 DEG C and digests 4h, and stirs 10min per hour with the revolving speed of 80r/min, then be placed in 30 DEG C,
It is centrifuged 30min under conditions of 2500r/min, obtains the first supernatant and Chinese medicine residue；
10 times of Chinese medicine mass of residue of distilled water is added in IV: Xiang Shangshu Chinese medicine residue, is in 60 DEG C, microwave power
Microwave treatment 8min under conditions of 560W, then be placed in 30 DEG C, be centrifuged 30min under conditions of 2500r/min, after removing solid residue
Obtain the second supernatant；
V, merges above-mentioned first supernatant, the second supernatant, is first placed in driving pressure 0.15MPa, under conditions of 25 DEG C
It carries out carrying out ultrafiltration using ultrafiltration membrane, gained ultrafiltrate is then placed in the condition that temperature is 50 DEG C, absolute pressure is 0.05MPa
Under be concentrated at 25 DEG C relative density be 1.1 to get.
The stabilizer is mixed by D- trehalose, lauroyl maltoside by the mass ratio of 1:1.
Embodiment 6
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, and first the dry 2h at 60 DEG C, is crushed to 60 mesh with medicinal herb grinder, obtains Chinese medicine coarse powder,
Then above-mentioned Chinese medicine coarse powder is put into 30 DEG C, ground in the ball-grinding machine of 300r/min, using the zirconium oxide of diameter 10mm
Ball as ball-milling medium, the ball-milling medium, Chinese medicine coarse powder mass ratio be 3:1, to be milled to particle diameter be 50 μm, is obtained
Medicinal powder end；
III, herb powder is added in 10 times of herb powder quality of distilled water, first impregnates 2h at 50 DEG C, is impregnated
Liquid, is subsequently added into pectase, cellulase, stabilizer, the soak, pectase, cellulase, stabilizer mass ratio be
100:2:4:0.8 is placed at 50 DEG C and digests 4h, and stirs 10min per hour with the revolving speed of 80r/min, then be placed in 30 DEG C,
It is centrifuged 30min under conditions of 2500r/min, obtains the first supernatant and Chinese medicine residue；
10 times of Chinese medicine mass of residue of distilled water is added in IV: Xiang Shangshu Chinese medicine residue, is in 60 DEG C, microwave power
Microwave treatment 8min under conditions of 560W, then be placed in 30 DEG C, be centrifuged 30min under conditions of 2500r/min, after removing solid residue
Obtain the second supernatant；
V, merges above-mentioned first supernatant, the second supernatant, is first placed in driving pressure 0.15MPa, under conditions of 25 DEG C
It carries out carrying out ultrafiltration using ultrafiltration membrane, gained ultrafiltrate is then placed in the condition that temperature is 50 DEG C, absolute pressure is 0.05MPa
Under be concentrated at 25 DEG C relative density be 1.1 to get.
The stabilizer is mixed by D- trehalose, lauroyl maltoside by the mass ratio of 1:1.
Embodiment 7
A kind of Chinese medicine composition for treating acute cough is prepared by following mass parts raw materials: 30 parts of honeysuckle, bitter apricot
15 parts of benevolence, 15 parts of Fructus Forsythiae.
The preparation method of the Chinese medicine composition of the treatment acute cough, comprising the following steps:
I, weighs each raw material component by mass parts；
II, sprays subzero 195 DEG C of liquid nitrogen into honeysuckle, and cool down embrittlement 3min, and the honeysuckle, liquid nitrogen mass ratio are
10:1 is then crushed to 60 mesh with medicinal herb grinder, obtains honeysuckle coarse powder；By the first 2h dry at 60 DEG C of other raw materials, use
Medicinal herb grinder is crushed to 60 mesh, and above-mentioned honeysuckle coarse powder is added, obtains Chinese medicine coarse powder, and above-mentioned Chinese medicine coarse powder is then put into 30
DEG C, ground in the ball-grinding machine of 300r/min, using the zirconia ball of diameter 10mm as ball-milling medium, the ball milling is situated between
Matter, Chinese medicine coarse powder mass ratio be 3:1, be milled to particle diameter be 50 μm, obtain herb powder；
III, herb powder is added in 10 times of herb powder quality of distilled water, first impregnates 2h at 50 DEG C, is impregnated
Liquid, is subsequently added into pectase, cellulase, stabilizer, the soak, pectase, cellulase, stabilizer mass ratio be
100:2:4:0.8 is placed at 50 DEG C and digests 4h, and stirs 10min per hour with the revolving speed of 80r/min, then be placed in 30 DEG C,
It is centrifuged 30min under conditions of 2500r/min, obtains the first supernatant and Chinese medicine residue；
10 times of Chinese medicine mass of residue of distilled water is added in IV: Xiang Shangshu Chinese medicine residue, is in 60 DEG C, microwave power
Microwave treatment 8min under conditions of 560W, then be placed in 30 DEG C, be centrifuged 30min under conditions of 2500r/min, after removing solid residue
Obtain the second supernatant；
V, merges above-mentioned first supernatant, the second supernatant, is first placed in driving pressure 0.15MPa, under conditions of 25 DEG C
It carries out carrying out ultrafiltration using ultrafiltration membrane, gained ultrafiltrate is then placed in the condition that temperature is 50 DEG C, absolute pressure is 0.05MPa
Under be concentrated at 25 DEG C relative density be 1.1 to get.
The stabilizer is mixed by D- trehalose, lauroyl maltoside by the mass ratio of 1:1.
Embodiment 8
Substantially the same manner as Example 7, difference is only in that: the Chinese medicine composition of the treatment acute cough, by following matter
Amount part raw material is prepared: 30 parts of honeysuckle, 15 parts of semen armeniacae amarae, 15 parts of Fructus Forsythiae, 9 parts of basil fruit, 9 parts of semen coicis.
Embodiment 9
Substantially the same manner as Example 7, difference is only in that: the Chinese medicine composition of the treatment acute cough, by following matter
Amount part raw material is prepared: 30 parts of honeysuckle, 15 parts of semen armeniacae amarae, 15 parts of Fructus Forsythiae, 9 parts of semen coicis, 9 parts of Euphorbia esula L.
Embodiment 10
Substantially the same manner as Example 7, difference is only in that: the Chinese medicine composition of the treatment acute cough, by following matter
Amount part raw material is prepared: 30 parts of honeysuckle, 15 parts of semen armeniacae amarae, 15 parts of Fructus Forsythiae, 9 parts of basil fruit, 9 parts of Euphorbia esula L.
Embodiment 11
Substantially the same manner as Example 7, difference is only in that: the Chinese medicine composition of the treatment acute cough, by following matter
Amount part raw material is prepared: 30 parts of honeysuckle, 15 parts of semen armeniacae amarae, 15 parts of Fructus Forsythiae, 6 parts of basil fruit, 6 parts of semen coicis, Euphorbia esula L 6
Part.
Test case 1
Mouse concentrated ammonia liquor draws cough experiment: " PERICARPIUM TRICHOSANTHIS different ratio compound preparation is to mouse for the periodical literature of reference Wang Ziyan
Relieving cough and reducing sputum influence " in experimental method in 2-11 of the embodiment of the present invention treat acute cough Chinese medicine composition cough-relieving
Effect carries out.Wherein this test case with weight 20g ± 2g ICR mouse (SPF grades, it is real by Heilongjiang University of Chinese Medicine animal
Center offer is provided) it is experimental subjects, mouse is randomly divided into 12 groups, every group 10, half male and half female, the 1st group is blank control group,
0.9% physiological saline of the daily gastric infusion 0.8g of every mouse, every mouse distinguishes gastric infusion daily in 2-11 group
The Chinese medicine composition of acute cough is treated in 0.8g embodiment 2-11.After successive administration 3d, start to test in 1h after the last administration:
Mouse is placed in 500mL glass bell jar, 25% concentrated ammonia liquor is quantitatively sprayed into, starts timing to there is misty ammonium hydroxide, spraying 20s,
With mouse contraction of abdominal muscle and magnifying mouth (can hear slight cough sometimes) simultaneously is cough index, observes and records each group mouse
Self-spray starts to the cough number occurred in the incubation period coughed and 5min, compares each group test result, by counting credit
Analysis method obtains P < 0.05, shows that sample average difference has statistical significance, specific test result is shown in Table 1.
Table 1: mouse concentrated ammonia liquor draws cough experiment
| Sample | The incubation period of cough/s | It coughs number (in 5min) |
| Blank control group | 27.8 | 103.1 |
| Embodiment 2 | 48.5 | 50.2 |
| Embodiment 3 | 53.3 | 46.5 |
| Embodiment 4 | 52.3 | 45.7 |
| Embodiment 5 | 61.7 | 38.2 |
| Embodiment 6 | 65.6 | 35.4 |
| Embodiment 7 | 72.1 | 33.7 |
| Embodiment 8 | 75.7 | 30.9 |
| Embodiment 9 | 76.2 | 30.5 |
| Embodiment 10 | 76.6 | 29.8 |
| Embodiment 11 | 78.8 | 28.2 |
By test result it is found that being added to stabilizer in embodiment 3-5 in raw material enzymolysis processing, cough suppressing effect is better than
The embodiment 2 of stabilizer is not used；And stabilizer is made of D- trehalose, lauroyl maltoside in embodiment 5, cough-relieving
Effect is better than embodiment 3-4 (stabilizer is only one of D- trehalose, lauroyl maltoside)；Using in embodiment 7
Crushing treatment method material is handled, and for embodiment 5, further enhances the Chinese traditional medicine composition for the treatment of acute cough
The cough suppressing effect of object.
Test case 2
Immune organ index detection: in order to measure immunological enhancement of the invention, to being controlled in 2-11 of the embodiment of the present invention
The thymus index for treating the Chinese medicine composition of acute cough detects.Experimental method: the ICR mouse of selection weight 20g or so
(SPF grades, provided by Heilongjiang University of Chinese Medicine's animal experimental center), half male and half female are divided into 11 groups, and every group is 10 small
Mouse manages identical.1st group is blank control group, the daily stomach-filling 0.2g physiological saline of every mouse；Every mouse of 2-11 group is every
The Chinese medicine composition 0.2g of embodiment 2-11 treatment acute cough is distinguished in its stomach-filling；The tested time is 7d.Fasting after tested
16h, cervical dislocation is put to death after weighing, and thymus gland is taken to weigh, and to the thymus gland organ index of each test mice and is cleaned up index and is examined
It surveys.Thymus index=thymic factor D injection (mg)/mouse weight (g).Compare each group test result, P is obtained by statistical analysis method
< 0.05 shows that sample average difference has statistical significance, and specific test result is shown in Table 2.
Table 2: the test result of immune organ index
| Sample | Thymus gland organ index/mgg-1 |
| Blank group | 2.55 |
| Embodiment 2 | 3.07 |
| Embodiment 3 | 3.22 |
| Embodiment 4 | 3.18 |
| Embodiment 5 | 3.35 |
| Embodiment 6 | 3.45 |
| Embodiment 7 | 3.61 |
| Embodiment 8 | 3.86 |
| Embodiment 9 | 3.82 |
| Embodiment 10 | 3.91 |
| Embodiment 11 | 4.35 |
Thymus gland is important immune organ, and the major function of thymus gland is to generate T lymphocyte and secretion thymosin extrasin, main to join
With cellular immunity, organ index can reflect the power of body's immunity to a certain extent.From test result as can be seen that
Basil fruit, semen coicis, any two kinds in Euphorbia esula L are added in the Chinese medicine composition of embodiment 8-11 treatment acute cough
Or three kinds of raw materials, the effect of strengthen immunity are better than embodiment 2-7 (being not added with basil fruit, semen coicis, Euphorbia esula L).
Test case 3
Clinical test: therapeutic effect test is carried out to the Chinese medicine composition of present invention treatment acute cough.Test method: choosing
Patient cases 220 are selected, wherein men and women is fifty-fifty, and the age, random to be grouped, every group of 20 people, everyone was daily between 20-50 years old
The 3g present invention treats the Chinese medicine composition of acute cough, observes and records test result after continuously taking 5.Curative effect determinate standard:
Effective: acute cough due to wind-cold evil's remission disappears；It cures: expelling wind and cold pathogens, ventilating the lung and relieving cough.Compare each group test result, passes through system
Meter learns analysis method and obtains P < 0.05, shows that sample average difference has statistical significance, specific test result is shown in Table 3.
Table 3: clinical test results
| Sample | Effectively/number | Healing/number |
| Embodiment 1 | 70 | 18 |
| Embodiment 2 | 77 | 20 |
| Embodiment 3 | 75 | 21 |
| Embodiment 4 | 79 | 19 |
| Embodiment 5 | 81 | 22 |
| Embodiment 6 | 84 | 24 |
| Embodiment 7 | 89 | 27 |
| Embodiment 8 | 91 | 29 |
| Embodiment 9 | 94 | 32 |
| Embodiment 10 | 92 | 30 |
| Embodiment 11 | 96 | 33 |
By test result it is found that the Chinese medicine composition that the present invention treats acute cough has significantly treatment acute cough
Therapeutic effect.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
The equivalent or simple change that all principles described according to the invention patent design are done, is included in the scope of protection of the patent of the present invention
It is interior；Those skilled in the art can make various modifications or additions to the described embodiments
Or be substituted in a similar manner, without departing from structure of the invention or beyond the scope defined by this claim,
It is within the scope of protection of the invention.
Claims (10)
1. a kind of Chinese medicine composition for treating acute cough, which is characterized in that its raw material includes honeysuckle, semen armeniacae amarae, Fructus Forsythiae.
2. the Chinese medicine composition for the treatment of acute cough as described in claim 1, which is characterized in that its raw material in parts by mass, wraps
Include 20-40 parts of honeysuckle, 10-20 parts of semen armeniacae amarae, 10-20 parts of Fructus Forsythiae.
3. as described in claim 1 treatment acute cough Chinese medicine composition, which is characterized in that its raw material further include basil fruit,
One of semen coicis, Euphorbia esula L are a variety of.
4. a kind of preparation method for the Chinese medicine composition for treating acute cough as described in any one of claim 1-3, feature
It is, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, is first placed at 50-60 DEG C dry 1-5h, is then crushed to 30-60 mesh with medicinal herb grinder, obtains
To herb powder；
The water of 5-15 times of herb powder quality is added into herb powder by III, impregnates 1-4h at 45-52 DEG C, obtains soak,
Then it is placed at 85-100 DEG C and decocts 1-3h, filter, obtain the first decoction liquor and filter residue；
The water of 5-15 times of filter residue quality is added into above-mentioned filter residue by IV, and 1-3h is decocted at 85-100 DEG C, and filtering obtains second
Decoction liquor；
V, merges above-mentioned first, second decoction liquor, then after ultrafiltration, concentration to obtain the final product.
5. a kind of preparation method for the Chinese medicine composition for treating acute cough as described in any one of claim 1-3, feature
It is, comprising the following steps:
I, weighs each raw material component by mass parts；
II, mixes each raw material, is first placed at 50-60 DEG C dry 1-5h, is then crushed to 30-60 mesh with medicinal herb grinder, obtains
To herb powder；
III, herb powder is added in the water of 5-15 times of herb powder quality, impregnates 1-4h at 45-52 DEG C, obtains soak,
Be subsequently added into complex enzyme, the soak, complex enzyme mass ratio be 100:(5-8), be placed at 45-52 DEG C and digest 3-5h, often
Hour stirring 10-20min, obtains the first supernatant and Chinese medicine residue after centrifugation；
The water of 5-15 times of Chinese medicine mass of residue is added into above-mentioned Chinese medicine residue by IV, and microwave treatment 4-12min, centrifugation, removal is admittedly
The second supernatant is obtained after body residue；
V, merges above-mentioned first supernatant, the second supernatant, then after ultrafiltration, concentration to obtain the final product.
6. the preparation method of the Chinese medicine composition for the treatment of acute cough as claimed in claim 5, which is characterized in that the complex enzyme
Press (1-3) by pectase, cellulase: the mass ratio of (2-6) forms.
7. the preparation method of the Chinese medicine composition for the treatment of acute cough as claimed in claim 5, which is characterized in that the step II
Are as follows: it each raw material is mixed, is first placed at 50-60 DEG C dry 1-5h, is then crushed to 30-60 mesh with medicinal herb grinder, obtain
Above-mentioned Chinese medicine coarse powder is then put into ball-grinding machine and grinds by medicine coarse powder, and being milled to particle diameter is 10-50 μm, obtains
Herb powder.
8. the preparation method of the Chinese medicine composition for the treatment of acute cough as claimed in claim 5, which is characterized in that the step II
Are as follows: subzero 195 DEG C-subzero 190 DEG C of liquid nitrogen is sprayed into honeysuckle, cool down embrittlement 2-5min, the honeysuckle, liquid nitrogen quality
Than for (8-12): 1, it is crushed to 30-60 mesh with medicinal herb grinder, obtains honeysuckle coarse powder；Other raw materials are placed at 50-60 DEG C
Dry 1-5h, is crushed to 30-60 mesh with medicinal herb grinder, above-mentioned honeysuckle coarse powder is added, obtains Chinese medicine coarse powder, then will be above-mentioned
Chinese medicine coarse powder, which is put into ball-grinding machine, to be ground, and being milled to particle diameter is 10-50 μm, obtains herb powder.
9. the preparation method of the Chinese medicine composition for the treatment of acute cough as claimed in claim 5, which is characterized in that the step III
Are as follows: herb powder is added in the water of 5-15 times of herb powder quality, first impregnates 1-4h at 45-52 DEG C, obtain soak, connect
Addition complex enzyme, stabilizer, the soak, complex enzyme, stabilizer mass ratio be 100:(5-8): (0.5-1.5) is set
3-5h is digested at 45-52 DEG C, stirs 10-20min per hour, the first supernatant and Chinese medicine residue are obtained after centrifugation.
10. the preparation method of the Chinese medicine composition for the treatment of acute cough as claimed in claim 9, which is characterized in that the stabilization
Agent includes one of D- trehalose, lauroyl maltoside or a variety of.
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