CN105660951A - Healthcare tea for preventing and treating respiratory system diseases caused by haze and preparation method thereof - Google Patents
Healthcare tea for preventing and treating respiratory system diseases caused by haze and preparation method thereof Download PDFInfo
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- CN105660951A CN105660951A CN201610095292.0A CN201610095292A CN105660951A CN 105660951 A CN105660951 A CN 105660951A CN 201610095292 A CN201610095292 A CN 201610095292A CN 105660951 A CN105660951 A CN 105660951A
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- fructus momordicae
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a healthcare tea for preventing and treating respiratory system diseases caused by haze and a preparation method thereof, and belongs to the technical field of healthcare food. The healthcare tea is prepared from 9-25 parts of momordica grosvenori, 9-15 parts of dendrobium officinale, 9-15 parts of common goldenrod herb, 6-12 parts of rhiaoma iridis tectori, 6-12 parts of radix asteris and 6-12 parts of folium sauropi. The preparation process of the healthcare tea includes the steps of soaking, decocting, filtering, drying and the like. The healthcare tea is unique in taste and convenient to drink, has a significant treatment effect on a swollen sore throat and a cough, and can effectively prevent and treat respiratory system diseases caused by haze.
Description
Technical field
The present invention relates to technical field of health care food, be specifically related to a kind of prevent and treat health tea of respiratory system disease that haze causes and preparation method thereof.
Background technology
Along with economic develops rapidly the quickening with urbanization process, China's overwhelming majority urban atmospheric pollution aggravates increasingly, on March 2nd, 2015, and China is much local occurs in that serious haze weather. Haze refers to that the aerosol systems of the particulate matter compositions such as substantial amounts of dust, sulphuric acid, nitric acid in air causes a kind of weather phenomenon that air is generally muddy. Haze weather wreak havoc not only severe jamming people orthobiosis, especially the health of human body is caused very big injury.
Respiratory system disease caused by haze, its cause of disease mostly is dry turbid combined pathogens folder poison. Patient with haze morbidity is common with the cough of old man and child clinically, and Young crowd is relatively fewer. Main manifestations is respiratory system disease, easily causes cough, dry pharynx, mouth and nose to dry.
Respiratory system disease caused by haze, the aerosol particle pollutant that its pathogenesis is mainly in haze weather enter trachea by respiratory tract, it is advanced into bronchioles even down, as deep as alveolar and deposit, blood capillary is entered by alveolar wall, cause the release of lung tissue inflammatory factor and the change of biochemical component, make respiratory tract local immunity power decline and pulmonary epithelial cells and fibrosis thus bringing out inflammation, and then produce the injury human bodies such as inflammatory damage, oxidative damage, carcinogenic toxicity.
Except considering except the speciality of disease own in the treatment of disease caused by haze, reference should also be made to haze pathogenic characteristic and the impact on respiratory system disease, strengthen the preventing and controlling to respiratory system disease such as cough, dry pharynx etc. that haze causes.
Summary of the invention
It is an object of the invention to provide a kind of health tea preventing and treating the respiratory system disease that haze causes;
The preparation method that it is a further object of the present invention to provide a kind of health tea preventing and treating the respiratory system disease that haze causes.
It is an object of the invention to by following technical scheme realization:
Fructus Momordicae health tea of the present invention, is be prepared from by the raw material of Chinese medicine of following weight portion:
Fructus Momordicae 9~25 parts, Herba Dendrobii 9~15 parts, Herba Solidaginis 9~15 parts, Rhizoma Belamcandae 6~12 parts, Radix Asteris 6~12 parts, 6~12 parts of leaf of dragon.
Preferably, it is be prepared from by the raw material of Chinese medicine containing following weight portion:
Fructus Momordicae 25 parts, Herba Dendrobii 12 parts, Herba Solidaginis 12 parts, Rhizoma Belamcandae 9 parts, Radix Asteris 6 parts, 6 parts of leaf of dragon.
The following is the crude drug source of the present invention:
Fructus Momordicae: this product is the dry fruit of cucurbitaceous plant Fructus Momordicae Siraitiagrosvenorii (Swingle) C.JeffreyexA.M.LuetZ.Y.Zhang. Autumn, fruit was gathered when being deepened green by peak green, after a couple of days of drying in the air, and cold drying. [nature and flavor with return through] are sweet, cool. Return lung, large intestine channel. [function with cure mainly] clearing heat and moistening lung, relieving sore throat to recover voice, laxation relieving constipation. For lung-heat type cough, pharyngalgia aphonia, dryness of the intestine constipation.
Herba Dendrobii: this product is the dry stem of orchid Herba Dendrobii DendrobiumofficinaleKimumetMigo. March in November to next year gathers, and removes impurity, cuts off part fibrous root, and limit heating edge is twisted into spiral type or spring-like, dries; Or cut into chunks, dry or oven drying at low temperature, the former practises title " Herba Dendrobii " (earrings dendrobium); The latter practises title " Herba Dendrobii ". [nature and flavor with return through] are sweet, are slightly cold. Return stomach, kidney channel. [function with cure mainly] reinforcing stomach reg fluid, nourishing YIN and clearing away heat. Hindering for calentura Tianjin, xerostomia excessive thirst, deficiency of stomach-Yin, lack of appetite is retched, and deficiency-heat is not moved back after being ill, hyperactivity of fire caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, poor vision, and muscles and bones flaccidity is soft.
Herba Solidaginis: this product is the dry herb of feverfew Herba Solidaginis SolidagodecurrensLour. Autumn, flowering fruit bearing stage was excavated, and removes silt, dries. [nature and flavor with return through] are pungent, bitter, cool. Return lung, Liver Channel. [function with cure mainly] heat-clearing and toxic substances removing, dispelling wind and heat pathogens. For sore throat, tonsillitis, laryngopharynx swelling and pain, furuncle toxic swelling, anemopyretic cold.
Rhizoma Belamcandae: this product is the dry rhizome of Yang Wei section plant mandarin duck tail IristectorumMaxim.. The whole year all can excavate, and removes fibrous root and silt, dry. [nature and flavor with return through] are bitter, cold. Return lung meridian. [function with cure mainly] heat-clearing and toxic substances removing, eliminates the phlegm, sore-throat relieving. For pyretic toxicity phlegm-fire pent-up, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.
Radix Asteris: this product is dry rhizome and the petiole residual base of the purple not OsmundajaponiacThunb. of Osmundaceae plant. Spring, season in autumn two excavate, and clean, and remove fibrous root, dry. [nature and flavor with return through] are bitter, be slightly cold; Slightly poisonous. Return lung, stomach, Liver Channel. [function with cure mainly] heat-clearing and toxic substances removing, hemostasis, parasite killing. Catch a cold for epidemic disease poison, pyretic toxicity dysentery, ulcerative carbuncle toxic swelling, spit blood, epistaxis, have blood in stool, metrorrhagia, abdominal pain due to worm stagnation.
Long Ye: this product is the dried leaves of euphorbia plant dragon leaf SauropusspatulifoliusBeille. Summer, season in autumn two gather, and dry. [nature and flavor with return through] are sweet, light, flat. Attach to the lung and stomach meridians. [function with cure mainly] nourishing the lung to arrest cough, relieving constipation. For xeropulmonary cough, pharyngalgia aphonia, constipation.
Side of the present invention solves: the respiratory system disease caused by haze, invades lungs for exopathogen, belongs to " lung-heat, cough " category in Chinese medicine, and " the big opinion of the hexa-atomic healthy energy of Plain Questions " is said: " strongly fragrant the sending out of gold, dryness is with row two ... gold is sound, therefore people's suffering from cough with dyspnea ". " the big opinion of Plain Questions gas alternation " cloud: " year gold too, dryness is popular ... very then cough with asthma is against gas " points out adverse weather, and dryness too may result in cough. So based on relieving sore-throat by clearing away heat, nourishing the lung to arrest cough in treatment, this product is with Fructus Momordicae clearing heat and moistening lung, and relieving sore throat to recover voice, for monarch drug;Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, nourishing the lung to arrest cough, for ministerial drug; Herba Solidaginis has effect of wind and heat dispersing, removing toxic substances and promoting subsidence of swelling, and Rhizoma Belamcandae has heat clearing away, removing toxic substances, the effect eliminated the phlegm, and Radix Asteris also has the effects such as nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, is adjuvant drug; Dragon leaf then eliminates the phlegm blood stasis dispelling, and depressed lung-energy dispersing, for making medicine. Gather nourishing YIN and moistening the lung altogether in full side, and the effect of smooth throat to stop cough meets the feature of differentiation of tcm.
Including several Chinese crude drug compositions of relieving sore-throat by clearing away heat, nourishing the lung to arrest cough in the formula of the present invention, the medicine major part in side broadly falls in " being medicine and the article of food " catalogue, and full side nature and flavor are gentle, and toxic and side effects is little, is suitable for crowd wide.
The preparation method that another aspect of the present invention there is provided health tea of the present invention, concrete preparation method is as follows:
(1) take Fructus Momordicae, Herba Dendrobii, after adding water soaking, then decoct 3~5 times, obtain Fructus Momordicae, Herba Dendrobii Aqueous extracts;
(2) take Rhizoma Belamcandae, Radix Asteris, add ethanol percolate extraction, after absorption with macroporous adsorbent resin, first wash post with water, discard eluent; Again with 50~70% ethanol elutions, collect eluent, obtain Rhizoma Belamcandae, Radix Asteris alcohol alcohol extract;
(3) take Herba Solidaginis, Long Ye, boiling 1~3 time, filter, merging filtrate, concentration, adding ethanol adjustment alcohol content is 50~60%, stands, filters, and obtains Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, to obtain final product.
Preferably, preparation method is as follows:
(1) taking Fructus Momordicae, Herba Dendrobii, the purified water 60~80 DEG C adding medical material gross weight 3~5 times is soaked 4~16 hours, filters; Adding the purified water of medical material gross weight 20~50 times in medicinal residues, decoct 3~5 times, each decocting time is 1.5~3 hours, filters, merging filtrate, and concentration obtains Fructus Momordicae, Herba Dendrobii Aqueous extracts;
(2) taking Rhizoma Belamcandae, Radix Asteris, pulverize, add 40~55% ethanol percolate extraction, extracting solution filters, concentrating under reduced pressure, dry, adds a small amount of ethanol and dissolves, puts macroporous adsorptive resins standing adsorption 1 hour; With the water elution of 4BV, discard eluent; Again with 50~70% ethanol elutions of 4BV, collect eluent, concentration, obtain Rhizoma Belamcandae, Radix Asteris alcohol alcohol extract;
(3) take Herba Solidaginis, Long Ye, pulverize, cross 60~100 mesh sieves, add 5~20 times of purified water of medical material gross weight, decocting 1~3 time, each decocting time is 0.5~3 hour, filters, merging filtrate, concentration, adding ethanol adjustment alcohol content is 50~60%, stands 12 hours, filter, obtain Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, to obtain final product.
Preferably, step 2) described macroporous adsorbent resin is HPD-500 macroporous adsorbent resin.
Provided by the invention a kind of prevent and treat health tea of respiratory system disease that haze causes and preparation method thereof and have the advantage that
1, health tea of the present invention has the effect of removing heat from the lung and relieving sorethroat, the turbid removing toxic substances of moisturizing, it is possible to the respiratory system disease that treatment dry pharynx, chronic cough etc. are caused by haze.
2, implant in experiment at mice cotton balls, compare with negative control group, the mice granuloma net amount taking the present invention is decreased obviously (P < 0.05), in mice antitussive is tested, compared with matched group, the mice taking the present invention can be obviously prolonged mouse cough incubation period (P < 0.01), in reducing mouse cough number of times, all has significant difference (P < 0.05).
3, the health tea of the present invention, formula is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
Further illustrate the present invention by the examples below. It should be understood that embodiments of the invention are an illustration for the present invention rather than limitation of the present invention. The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the scope of protection of present invention.
Embodiment 1
(1) Fructus Momordicae 9g, Herba Dendrobii 9g are taken, the purified water 60 DEG C adding medical material gross weight 3 times is soaked 4 hours, filters, adds the purified water of medical material gross weight 20 times in medicinal residues, decoct 3 times, each decocting time respectively 3 hours, 2 hours, 1.5 hours; Filtering, merge filtrate, filtrate concentrates, and obtains Fructus Momordicae, Herba Dendrobii aqueous extract;
(2) taking Rhizoma Belamcandae 6g, Radix Asteris 6g, pulverize, add 55% ethanol percolate extraction, extracting solution filters, concentrating under reduced pressure, dry, then adds the dissolving of a small amount of ethanol, puts HPD-500 macroporous adsorptive resins standing adsorption 1 hour, with the water elution of 2BV, discards eluent; Again with 70% ethanol elution of 3BV, collect eluent, concentration, obtain Rhizoma Belamcandae, Radix Asteris alcohol extract;
(3) take Herba Solidaginis 9g, dragon leaf 6g, pulverize, cross 100 mesh sieves, add the purified water of medical material gross weight 20 times, decoct 3 times, each decocting time respectively 3 hours, 2 hours, 0.5 hour; Filtering, merging filtrate, after filtrate concentration, adding ethanol adjustment is 60% to alcohol content, stands 12 hours, obtains Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, add adjuvant lactose, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, xylitol, mannitol, mix homogeneously, kneading, granulate, be drying to obtain.
Embodiment 2
(1) Fructus Momordicae 25g, Herba Dendrobii 15g are taken, the purified water 80 DEG C adding medical material gross weight 5 times is soaked 16 hours, filters, adds the purified water of medical material gross weight 50 times in medicinal residues, decoct 5 times, each decocting time respectively 3,2,2,1.5,1.5 hours; Filtering, merge filtrate, filtrate concentrates, and obtains Fructus Momordicae, Herba Dendrobii aqueous extract;
(2) take Rhizoma Belamcandae 12g, Radix Asteris 12g, pulverize, add 40% ethanol percolate extraction, extracting solution filters, concentrating under reduced pressure, dry, add a small amount of ethanol again to dissolve, put HPD-500 macroporous adsorptive resins to stand 1 hour, with the water elution of 5BV, discard eluent, again with 50% ethanol elution of 6BV, collect eluent, concentration, obtain Rhizoma Belamcandae, Radix Asteris alcohol extract;
(3) Herba Solidaginis 15g, dragon leaf 12g are taken, pulverize, cross 60 mesh sieves, add the purified water of medical material gross weight 5 times, decoct 1 time, each decocting time is 0.5 hour, filters, merging filtrate, after filtrate concentration, add ethanol adjustment and reach 50 to alcohol content, stand 12h, obtain Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, add adjuvant lactose, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, xylitol, mannitol, mix homogeneously, kneading, granulate, be drying to obtain.
Embodiment 3
(1) Fructus Momordicae 25g, Herba Dendrobii 12g are taken, add purified water to soak 10 hours at 70 DEG C, filter, adding the purified water being equivalent to medical material gross weight 30 times in medicinal residues, decoct 4 times, each decocting time is 2 hours, filter, merging filtrate, filtrate concentrates, and obtains Fructus Momordicae, Herba Dendrobii aqueous extract;
(2) take Rhizoma Belamcandae 9g, Radix Asteris 6g, pulverize, add 50% ethanol percolate extraction, extracting solution filters, concentrating under reduced pressure, dry, add a small amount of ethanol again to dissolve, it is placed in macroporous adsorptive resins to stand 1 hour, with the water elution of 4BV, discards eluent, again with 60% ethanol elution of 4BV, collect eluent, concentration, obtain Rhizoma Belamcandae, Radix Asteris alcohol extract;
(3) Herba Solidaginis 12g, dragon leaf 6g are taken, pulverize, cross 80 mesh sieves, add the purified water being equivalent to medical material gross weight 15 times, decoct 2 times, each decocting time is 2 hours, filters, merging filtrate, after filtrate concentration, add ethanol adjustment and reach 55% to alcohol content, stand 12 hours, obtain Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, add adjuvant lactose, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, xylitol, mannitol, mix homogeneously, kneading, granulate, be drying to obtain.
Comparative example 1
Take Fructus Momordicae 91g, add purified water under 110 DEG C of conditions, soak 8h, filter, adding the purified water being equivalent to medical material gross weight 30 times, repeat to decoct 3 times, each decocting time is 2 hours, filter, united extraction liquid, concentration, obtain Fructus Momordicae water extract, after drying, enter adjuvant lactose, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, xylitol, mannitol, mix homogeneously, kneading, granulate, it is drying to obtain.
Comparative example 2
Take Herba Dendrobii 91g, add purified water under 110 DEG C of conditions, soak 8h, filter, adding the purified water being equivalent to medical material gross weight 30 times, repeat to decoct 3 times, each decocting time is 2 hours, filter, united extraction liquid, concentration, obtain Herba Dendrobii water extract, after drying, enter adjuvant lactose, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, xylitol, mannitol, mix homogeneously, kneading, granulate, it is drying to obtain.
Comparative example 3
Take Fructus Momordicae 25g, Herba Dendrobii 12g, Rhizoma Belamcandae 9g, Radix Asteris 6g, Herba Solidaginis 12g, dragon leaf 6g, add purified water under 110 DEG C of conditions, soak 8h, filter, add the purified water being equivalent to medical material gross weight 30 times, repeat to decoct 3 times, each decocting time is 2 hours, filter, united extraction liquid, concentration, obtain water extract, after drying, enter adjuvant lactose, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, xylitol, mannitol, mix homogeneously, kneading, granulate, it is drying to obtain.
Pharmacodynamics test
1 experiment material
1.1 animals
SPF level Kunming mouse, body weight 18~22g, male and female half and half, buy from Guangxi Medical University's Experimental Animal Center (production licence number: SCXK osmanthus 2015-0003).
1.2 given the test agent and reagent
The embodiment of the present invention 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2, comparative example 3.
25 ammonia, ampicillin, aspirin, pentoxyverine citrate sheet.
1.3 instruments
Electronic balance, automatic high pressure steriliser, operating theater instruments, thermostatic drying chamber, ether, povidone iodine, absorbent cotton, depilator, ultrasonic atomizatio draw coughs device etc.
2 experimental techniques
2.1 mice cotton balls implant experiment
Experiment terminates first 8 days, the hair at axillary fossa place, mice both sides is sloughed with depilator, mice makes otch under ether light anaesthesia aseptic condition, by cotton balls of weighing, through autoclaving, each cotton balls plus ampicillin 1mg/0.1mL again, after 50 DEG C of oven for drying, implant mice both sides axillary fossa subcutaneous, blank group it is randomly divided into after bundle, positive group and 3 embodiments, 3 comparative example test medicine groups, embodiment test medicine group gives the given the test agent of various dose, blank group gives distilled water, positive drug group gives aspirin, therapeutic component does not give embodiment 1, 2 and embodiment 3 preparation sample, dosage is by medical material crude drug amount 19.5g/kg,Comparative example gives the sample of comparative example 1,2,3 preparation, and dosage presses medical material crude drug amount 19.5g/kg. Every day gavage 1 time, continuous gavage 30d. Experiment terminates the same day again to a given the test agent, and after 1 hour, disconnected neck puts to death mice, peels off and take out cotton balls granulation tissue, weighs after 1 hour in 60 DEG C of baking oven inner dryings, deducts raw cotton ball weight, be granuloma net amount. Relatively each dosage group and blank group granuloma weight.
Granuloma net amount (mg)=dried granuloma induced by implantation of cotton pellets weight-raw cotton ball weight
2.2 mice antitussive experiments
Take SPF level Kunming mouse 90, male, body weight 18~22g, it is placed in special glass bell jar, uses ultrasonic atomizatio aerosol apparatus to carry out 25 strong aqua ammonia metered dose, take out immediately after 10 seconds, record mice starts to incubation period cough occur from accepting spraying, and 2 minutes interior cough number of times. The latter 2 minutes not cough persons that spray give up. Qualified mice natural feeding takes 10 at random after 2 days and is only used as blank group, residue animal is randomly divided into negative control group, positive controls, test medicine embodiment 1, embodiment 2 and embodiment 3 groups, comparative example 1 group, comparative example 2 groups, comparative example 3 groups, totally 9 groups, often group 10.
Blank group in draw cough experiment before select packet at random, do not carry out strong aqua ammonia spraying. Often organizing respectively by matched doses each in table 2 (calculating by crude drug amount) gavage 30 days continuously, blank group gives equivalent distilled water with negative control group, and in daily before weighing and record. Before experiment, water 12h is can't help in fasting, is administered latter 1 hour in last, accepts 25 strong aqua ammonia metered dose respectively, take out immediately after 10 seconds. Record mice starts to incubation period and 2 minutes interior cough number of times cough occur from accepting spraying, has no cough person and remembered with 120 seconds its incubation period in 2 minutes. Each group medicine antitussive action represents to press down the rate of coughing (%Inhibition), %Inhibition=[(C0-Ct)/CO], wherein C0Representing the cough number of times of mice before administration, Ct represents the cough number of times of mice after administration.
3 statistical procedures
Experimental data adopt SPSS19.0 carry out statistical procedures, continuous data withRepresenting, comparing the t inspection adopting two sample averages between group, between many groups, sample average compares employing variance analysis; Think there is significant difference with P < 0.05.
4 experimental results are in Table 1, table 2.
The each embodiment group of table 1 on the impact of mice granuloma induced by implantation of cotton pellets (N=10)
Note: compare with model group, Δ represents P < 0.05, and Δ Δ represents P < 0.01; Compared with comparative example 1 group, * * represents P < 0.01; Comparing with comparative example 2 groups, ## represents P < 0.01; Compared with comparative example 3 groups, ※ represents P < 0.05.
Result: given the test agent mice cotton balls is implanted in experiment, and embodiment group is compared with model group, and granuloma net amount is all decreased obviously, and has significant difference (P < 0.01) through statistical disposition.
The each embodiment group of table 2 to the antitussive effect of mice (N=10)
Note: compare with model group, Δ represents P < 0.05, and Δ Δ represents P < 0.01; Compared with comparative example 1 group, * * represents P < 0.01; Comparing with comparative example 2 groups, ## represents P < 0.01; Compared with comparative example 3 groups, ※ represents P < 0.05.
Table 1, table 2 result show: administration group is compared with matched group, it is possible to be obviously prolonged mouse cough incubation period, wherein 3 groups of best results of test medicine embodiment (P < 0.01); Each embodiment group compares with comparative example group, in reducing mouse cough number of times, all there is significant difference (P < 0.05 or P < 0.01), especially with 3 groups of best results of test medicine embodiment (P < 0.01).Prompting, various embodiments of the present invention group, compared with comparative example group, is extending mouse cough incubation period and is reducing in mouse cough number of times effect substantially better; Comparative example 3 is inventive formulation prescription Chinese medicine, uses general extraction methods, although effect is not as good as embodiment, but curative effect is still significantly better than comparative example 1, comparative example 2.
Conclusion: comprehensive indices, each embodiment group and comparative example 3 all have good antitussive effect. Pointing out medical material of the present invention composition compared with prior art to have the curative effect of the respiratory system disease that significance preventing and treating haze causes, especially with preparation method gained Chinese medicine composition of the present invention, curative effect is extremely notable.
Although, above use generality explanation, detailed description of the invention and test, the present invention is described in detail, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art. Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (6)
1. the health tea preventing and treating the respiratory system disease that haze causes, it is characterized in that, it is prepared by the raw material of Chinese medicine of weight portion and is prepared from: Fructus Momordicae 9 25 parts, Herba Dendrobii 9 15 parts, Herba Solidaginis 9 15 parts, Rhizoma Belamcandae 6 12 parts, Radix Asteris 6 12 parts, 6 12 parts of leaf of dragon.
2. health tea as claimed in claim 1, it is characterised in that it is prepared by the raw material of Chinese medicine of weight portion and is prepared from: Fructus Momordicae 25 parts, Herba Dendrobii 12 parts, Herba Solidaginis 12 parts, Rhizoma Belamcandae 9 parts, Radix Asteris 6 parts, 6 parts of leaf of dragon.
3. the health tea of the respiratory system disease that preventing and treating haze as claimed in claim 1 or 2 causes, it is characterised in that its active component is prepared from by the following method:
(1) take Fructus Momordicae, Herba Dendrobii, after adding water soaking, then decoct 35 times, obtain Fructus Momordicae, Herba Dendrobii Aqueous extracts;
(2) take Rhizoma Belamcandae, Radix Asteris, add ethanol percolate extraction, after absorption with macroporous adsorbent resin, first wash post with water, discard eluent; Again with 50 70% ethanol elutions, collect eluent, obtain Rhizoma Belamcandae, Radix Asteris alcohol alcohol extract;
(3) take Herba Solidaginis, Long Ye, boiling 13 times, filter, merging filtrate, concentration, adding ethanol adjustment alcohol content is 50 60%, stands, filters, and obtains Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, to obtain final product.
4. the health tea of the respiratory system disease that preventing and treating haze as claimed in claim 3 causes, it is characterised in that its active component is prepared from by the following method:
(1) taking Fructus Momordicae, Herba Dendrobii, the purified water 60 80 DEG C adding medical material gross weight 35 times is soaked 4 16 hours, filters; Adding the purified water of medical material gross weight 20 50 times in medicinal residues, decoct 35 times, each decocting time is 1.5 3 hours, filters, merging filtrate, and concentration obtains Fructus Momordicae, Herba Dendrobii Aqueous extracts;
(2) taking Rhizoma Belamcandae, Radix Asteris, pulverize, add 40 55% ethanol percolate extraction, extracting solution filters, concentrating under reduced pressure, dry, adds a small amount of ethanol and dissolves, puts macroporous adsorptive resins standing adsorption 1 hour; With the water elution of 2-5BV, discard eluent; Again with 50 70% ethanol elutions of 3-6BV, collect eluent, concentration, obtain Rhizoma Belamcandae, Radix Asteris alcohol alcohol extract;
(3) take Herba Solidaginis, Long Ye, pulverize, cross 60 100 mesh sieves, add 5 20 times of purified water of medical material gross weight, decocting 13 times, each decocting time is 0.5 3 hours, filters, merging filtrate, concentration, adding ethanol adjustment alcohol content is 50 60%, stands 12 hours, filter, obtain Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, to obtain final product.
5. the health tea of the respiratory system disease that preventing and treating haze as claimed in claim 3 causes, it is characterised in that its active component is prepared from by the following method:
(1) taking Fructus Momordicae, Herba Dendrobii, the purified water 70 DEG C adding medical material gross weight 4 times is soaked 10 hours, filters; Adding the purified water of medical material gross weight 30 times in medicinal residues, decoct 4 times, each decocting time is 2 hours, filters, merging filtrate, and concentration obtains Fructus Momordicae, Herba Dendrobii Aqueous extracts;
(2) taking Rhizoma Belamcandae, Radix Asteris, pulverize, add 50% ethanol percolate extraction, extracting solution filters, concentrating under reduced pressure, dry, adds a small amount of ethanol and dissolves, puts macroporous adsorptive resins standing adsorption 1 hour; With the water elution of 4BV, discard eluent; Again with 60% ethanol elution of 4BV, collect eluent, concentration, obtain Rhizoma Belamcandae, Radix Asteris alcohol alcohol extract;
(3) take Herba Solidaginis, Long Ye, pulverize, cross 80 mesh sieves, add 15 times of purified water of medical material gross weight, decoct 2 times, each decocting time is 2 hours, filters, merging filtrate, concentration, adding ethanol adjustment alcohol content is 55%, stands 12 hours, filters, and obtains Herba Solidaginis, dragon leaf extract;
(4) by step 1) 2) 3) mixing of the extracting solution of gained, dry, to obtain final product.
6. the health tea of the respiratory system disease that preventing and treating haze as claimed in claim 3 causes, it is characterised in that step 2) described macroporous adsorbent resin is HPD-500 macroporous adsorbent resin.
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CN105943836A (en) * | 2016-06-28 | 2016-09-21 | 青岛浩大海洋保健食品有限公司 | Lily honey paste for preventing and treating respiratory diseases caused by haze |
CN106377673A (en) * | 2016-08-29 | 2017-02-08 | 江苏神华药业有限公司 | Composition having functions of clearing lung and preventing haze, and preparation method thereof |
CN106418530A (en) * | 2016-08-25 | 2017-02-22 | 苏州神元生物科技股份有限公司 | Health care product capable of clearing heat from throat |
CN108888715A (en) * | 2018-08-02 | 2018-11-27 | 云南德彩堂生物医药科技有限公司 | A kind of composition reducing haze particulate matter sucking associated diseases |
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CN105943836A (en) * | 2016-06-28 | 2016-09-21 | 青岛浩大海洋保健食品有限公司 | Lily honey paste for preventing and treating respiratory diseases caused by haze |
CN106418530A (en) * | 2016-08-25 | 2017-02-22 | 苏州神元生物科技股份有限公司 | Health care product capable of clearing heat from throat |
CN106377673A (en) * | 2016-08-29 | 2017-02-08 | 江苏神华药业有限公司 | Composition having functions of clearing lung and preventing haze, and preparation method thereof |
CN108888715A (en) * | 2018-08-02 | 2018-11-27 | 云南德彩堂生物医药科技有限公司 | A kind of composition reducing haze particulate matter sucking associated diseases |
CN108888715B (en) * | 2018-08-02 | 2021-03-23 | 云南德彩堂生物医药科技有限公司 | Composition, preparation method and application thereof |
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