CN111329966A - Traditional Chinese medicine composition for treating skin itch and extract and preparation thereof - Google Patents

Traditional Chinese medicine composition for treating skin itch and extract and preparation thereof Download PDF

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CN111329966A
CN111329966A CN202010244947.2A CN202010244947A CN111329966A CN 111329966 A CN111329966 A CN 111329966A CN 202010244947 A CN202010244947 A CN 202010244947A CN 111329966 A CN111329966 A CN 111329966A
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parts
extract
radix
chinese medicine
traditional chinese
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赵燕琼
李勇华
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Chongqing Three Gorges Medical College
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Chongqing Three Gorges Medical College
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/185Magnoliopsida (dicotyledons)
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Abstract

The invention relates to a traditional Chinese medicine composition for treating skin itch as well as an extract and a preparation thereof, belonging to the technical field of medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-20 parts of caulis perllae, 10-20 parts of tribulus terrestris, 15-25 parts of radix rehmanniae, 5-15 parts of cape jasmine, 5-15 parts of lophatherum gracile, 20-40 parts of concha haliotidis, 3-9 parts of coptis chinensis, 5-15 parts of cortex mori, 5-15 parts of radix ophiopogonis, 10-20 parts of lalang grass rhizome, 1-5 parts of raw rhubarb, 3-9 parts of schisandra chinensis, 3-9 parts of dark plum, 10-20 parts of rhizoma anemarrhenae, 5-20 parts of starwort root, 10-20 parts of cortex phellodendri and 3-9 parts of raw liquorice. The composition has a remarkable treatment effect on skin itch, is safe and has no toxic or side effect, and the invention provides a granular Chinese medicinal preparation which is convenient to carry and take.

Description

Traditional Chinese medicine composition for treating skin itch and extract and preparation thereof
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating skin itch as well as an extract and a preparation thereof.
Background
Pruritus is a dermatological condition in which there is only itching of the skin and no primary skin lesions. Generally, the skin itch is classified into general and limited types according to the extent and location of the skin itch. Among them, general pruritus is often found in adults, and pruritus usually begins at one place and gradually spreads to the whole body. It is often paroxysmal, especially at night, and persistent pruritus with paroxysmal aggravation in severe cases, and the onset and aggravation of pruritus can be promoted by drinking, coffee, tea, mood changes, pungent and pungent food stimulation, mechanical scratching, warm bedding and even some kind of suggestion. Scratch, blood crust, pigmentation, eczema, lichenification, pyoderma, lymphadenitis and lymphadenitis are often secondary to the disease.
Skin pruritus is a common disease and a common disease of skin diseases. The clinical manifestations are mainly the subjective symptoms of skin pruritus or pruritus, or accompanied by rash spots, blisters, desquamation and redness of skin, even desquamation and ulceration, and the part can be in a certain part or a larger range of the whole body. According to the theory of traditional Chinese medicine, skin itch is caused by the invasion of pathogenic factors such as wind, dampness, heat, worms and the like on the skin surface, and qi and blood in the surface are not harmonized. It is also caused by blood deficiency, wind dryness and malnutrition of the skin. The syndrome differentiation includes deficiency and excess, while excess involves wind-prevailing, damp-prevailing, heat-prevailing and parasites-prevailing; the blood deficiency is the main reason for deficiency. Wind, dampness, heat, parasites and blood deficiency may occur singly or in combination. In treatment, oral administration and external washing are combined, and the patients with mild symptoms are taken orally, while the patients with severe symptoms or stubborn symptoms and difficult healing are treated by external washing. Wind, dampness, heat, insect and blood deficiency are common pathogenesis of skin pruritus, but the common pathogenesis of the skin pruritus is wind. Skin pruritus is usually chronic disease, difficult to rapidly solve and easy to recur.
Disclosure of Invention
In view of the above, one of the objectives of the present invention is to provide a Chinese medicinal composition for treating skin pruritus; the second purpose is to provide an extract of the traditional Chinese medicine composition for treating skin itch; the third purpose is to provide a medicinal preparation taking the extract of the traditional Chinese medicine composition for treating skin itch as an active ingredient; the fourth purpose is to provide the application of the traditional Chinese medicine composition or the extract of the traditional Chinese medicine composition in preparing the medicine for treating the skin itch.
In order to achieve the purpose, the invention provides the following technical scheme:
1. a traditional Chinese medicine composition for treating skin itch comprises the following components in parts by weight: 10-20 parts of caulis perllae, 10-20 parts of tribulus terrestris, 15-25 parts of radix rehmanniae, 5-15 parts of cape jasmine, 5-15 parts of lophatherum gracile, 20-40 parts of concha haliotidis, 3-9 parts of coptis chinensis, 5-15 parts of cortex mori, 5-15 parts of radix ophiopogonis, 10-20 parts of lalang grass rhizome, 1-5 parts of raw rhubarb, 3-9 parts of schisandra chinensis, 3-9 parts of dark plum, 10-20 parts of rhizoma anemarrhenae, 5-20 parts of starwort root, 10-20 parts of cortex phellodendri and 3-9 parts of raw liquorice.
Preferably, the composition comprises the following components in parts by weight: 15 parts of caulis perllae, 15 parts of tribulus terrestris, 20 parts of radix rehmanniae, 10 parts of cape jasmine, 10 parts of lophatherum gracile, 30 parts of concha haliotidis, 6 parts of coptis chinensis, 10 parts of cortex mori, 10 parts of radix ophiopogonis, 15 parts of lalang grass rhizome, 3 parts of raw rhubarb, 6 parts of schisandra chinensis, 6 parts of dark plum, 15 parts of rhizoma anemarrhenae, 10 parts of starwort root, 15 parts of cortex phellodendri and 6 parts of raw liquorice.
2. The extract of the traditional Chinese medicine composition for treating the skin itch.
Preferably, the preparation method comprises the following steps:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water with the weight being 8-10 times of that of the mixture, decocting for 1-2h, filtering to obtain filtrate, repeatedly decocting for 1-2 times, combining the filtrates, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.00-1.05 at 60 deg.C for use;
(3) adding absolute ethanol into the fluid extract obtained in the step (2) under stirring to obtain a mixture, and standing the mixture at 5-8 ℃ for 24-32h for later use, wherein the volume ratio of the absolute ethanol to the fluid extract is 0.65-0.75: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.20-1.30 at 60 ℃.
Preferably, the preparation method comprises the following steps:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water 9 times the weight of the mixture, decocting for 1.5h, filtering to obtain filtrate, repeatedly decocting for 2 times, mixing the filtrates, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.00-1.05 at 60 deg.C;
(3) adding absolute ethyl alcohol into the clear paste obtained in the step (2) under stirring to obtain a mixture, and standing the mixture at 6 ℃ for 24 hours for later use, wherein the volume ratio of the absolute ethyl alcohol to the clear paste is 0.7: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.20-1.30 at 60 ℃.
3. The medicinal preparation takes the extract of the traditional Chinese medicine composition for treating the skin itch as an active ingredient.
Preferably, the dosage form of the pharmaceutical preparation is, but not limited to, one of oral liquid, tablets and granules.
Preferably, when the dosage form of the pharmaceutical preparation is granules, the pharmaceutical preparation is prepared by the following method:
mixing the extract of the traditional Chinese medicine composition for treating skin itch with auxiliary materials, granulating through a 14-mesh screen, drying at 60-65 ℃, and then sieving through a 10-mesh screen to complete granules.
Preferably, the mass ratio of the extract to the auxiliary material is 1:10, and the auxiliary material is formed by mixing dextrin and powdered sugar according to the mass ratio of 1: 1.
4. The traditional Chinese medicine composition for treating the skin itch or the application of the extract of the traditional Chinese medicine composition for treating the skin itch in preparing the medicine for treating the skin itch.
The medicinal materials used by the invention have the following curative effects:
and (3) climbing vine: clear heat and remove toxicity, break stasis and regenerate tissue.
Tribulus terrestris: disperse wind and promote blood circulation.
Radix rehmanniae: clear heat and promote fluid production, nourish blood and cool blood.
Gardenia: purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and removing toxicity.
Herba lophatheri: clearing away heart-fire, promoting urination, and relieving restlessness.
Abalone shell: pacify liver and subdue yang, remove heat.
Coptis chinensis: clearing away heat, purging fire and removing toxic substance.
White mulberry root-bark: clear and purge lung heat.
Radix ophiopogonis: moisten lung, clear heart fire, purge heat and promote fluid production.
Cogongrass rhizome: cool blood, clear heat and induce diuresis.
Raw rhubarb: clearing hollow viscera and purging heat.
Schisandra chinensis: astringe lung, nourish kidney, promote fluid production, astringe sweat and astringe essence.
Dark plum: astringe lung and intestines, promote the production of body fluid.
Rhizoma anemarrhenae: clear heat and purge fire, nourish yin and moisten dryness.
Radix Stellariae: clear deficiency heat and remove malnutritional heat.
Phellodendron bark: clear heat and dry dampness, purge fire and remove steam, remove toxicity and cure sore.
Raw licorice root: clear heat and remove toxicity, and harmonize the recipe.
① skin itch is mostly blood heat, actually it is excessive heat, deficiency heat coexisting, so the recipe has Coptidis rhizoma, cortex Mori, fructus Gardeniae, etc. clear excess heat, also have radix Stellariae, rhizoma anemarrhenae, cortex Phellodendri clear deficiency heat, ② skin itch is related to the five internal organs, the disease of excess heat locates heart, liver, lung and stomach, fructus Gardeniae, herba Lophatheri clear heart fire, Concha Haliotidis calms the liver, cortex Mori clears lung heat, Coptidis rhizoma clears heart and stomach fire, deficiency heat (yin deficiency) locates heart, liver and kidney, radix Ophiopogonis educes heart yin, fructus Schisandrae chinensis, fructus mume educe liver yin, radix rehmanniae nourish kidney yin, ③ heat clearing way is upper and lower, Concha Haliotidis calms liver fire liver yang and calms out wind, herba Lophatheri, fructus Gardeniae, rhizoma Imperatae clear heart and induce fever, induce heat from the stool two times and go to ④ wind fire and extinguish, Concha Haliotidis calms liver wind, fructus mume, liver and liver fire, shut down wind, many heat in the area of the sanxia kuai, ⑤ applies the Tianxiao canu kou gu.
The invention has the beneficial effects that: the invention provides a traditional Chinese medicine composition for treating skin itch as well as an extract and a preparation thereof. Wherein, the caulis seu radix Schisandrae Henryi and fructus Tribuli have the effects of dispelling pathogenic wind and relieving itching, and radix rehmanniae has the effects of nourishing blood and cooling blood, and fructus Gardeniae has the effects of clearing heart fire and relieving restlessness, and is the monarch drug. Abalone shell, coptis root, mulberry bark, rhizoma imperatae and lophatherum gracile are used for clearing liver fire, clearing heart fire, promoting urination, removing heat from the large intestine and inducing fire to go downwards, and are combined as ministerial drugs. Ophiopogon root, radix Ophiopogonis nourishes heart yin, Schisandra chinensis fruit, dark plum fruit, fructus Schisandrae chinensis, fructus mume, nourishing yin and softening liver, assisting in extinguishing wind, Stellaria root, rhizoma anemarrhenae, cortex Phellodendri, assisting in clearing and reducing deficiency fire, are used as adjuvant drugs in combination. Raw licorice root, radix Glycyrrhizae Praeparata coordinates the effects of the other drugs in the recipe, in order to make sure. The composition has a remarkable treatment effect on skin itch, is safe and has no toxic or side effect, and the invention provides a granular Chinese medicinal preparation which is convenient to carry and take.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention may be realized and attained by the means of the instrumentalities and combinations particularly pointed out hereinafter.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Example 1
A traditional Chinese medicine composition for treating skin itch comprises the following components in parts by weight: 15 parts of caulis perllae, 15 parts of tribulus terrestris, 20 parts of radix rehmanniae, 10 parts of cape jasmine, 10 parts of lophatherum gracile, 30 parts of concha haliotidis, 6 parts of coptis chinensis, 10 parts of cortex mori, 10 parts of radix ophiopogonis, 15 parts of lalang grass rhizome, 3 parts of raw rhubarb, 6 parts of schisandra chinensis, 6 parts of dark plum, 15 parts of rhizoma anemarrhenae, 10 parts of starwort root, 15 parts of cortex phellodendri and 6 parts of raw liquorice.
The preparation of the granular formulation is prepared by the traditional Chinese medicine composition according to the following method:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water 9 times the weight of the mixture, decocting for 1.5h, filtering to obtain filtrate, repeatedly decocting for 2 times, mixing the filtrates, and concentrating under reduced pressure to obtain fluid extract with relative density of 1 at 60 deg.C;
(3) adding absolute ethanol into the fluid extract obtained in the step (2) under stirring to obtain a mixture, and standing the mixture at 6 ℃ for 24h for later use, wherein the volume ratio of the absolute ethanol to the fluid extract is 0.7: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.2 at 60 ℃ to obtain the extract of the traditional Chinese medicine composition;
(5) and (3) uniformly mixing the extract obtained in the step (4) with auxiliary materials (prepared by mixing dextrin and sugar powder according to the mass ratio of 1: 1) according to the mass ratio of 1:10, granulating by using a 14-mesh screen, drying at 65 ℃, grading by using a 10-mesh screen, and packaging by using 15g bags.
Clinical case efficacy analysis
The inclusion standard meets the clinical diagnosis standard of cutaneous pruritus in clinical dermatology, and patients only have paroxysmal cutaneous pruritus, no primary skin damage, large fluctuation of emotion and temperature difference before sleep, and aggravated situations when eating irritant food; the age is more than or equal to 60 years old; the syndrome differentiation of the traditional Chinese medicine is blood deficiency and wind dryness; the patients are not treated by drugs such as glucocorticoid within 1 month before entering the group. Eliminating the dysfunction of important organs; other types of skin disorders; a malignant tumor; a psychiatric disorder; drug allergy; the follow-up visit was lost.
98 patients with senile pruritus are divided into A, B groups by using a random number table method. Group a of 49, 28 men and 21 women; the age is 60-78 years, and the average (69.81 +/-3.36) years; the course of the disease is 4-22 months, and the average (10.49 +/-2.62) months. Group B49, 25 men and 24 women, aged 60-77 years, mean (69.69 + -3.25) years; the course of the disease is 5-25 months, and the average (10.63 +/-2.40) months. The difference was not statistically significant (P > 0.05) when compared between the two baseline data sets.
The intervention method comprises the following steps: group A is treated by oral administration of cetirizine hydrochloride tablet only, 10 mg/time and 1 time/d. The traditional Chinese medicine composition granules for treating skin itch in example 1 are additionally taken in the group B on the basis of the treatment of the group A, 1 bag of the traditional Chinese medicine composition granules is taken with warm water every time, 2 times a day, and 14 days are 1 course of treatment. The two groups are administered continuously for 2 treatment courses.
The curative effect standard is as follows: the pruritus areas before and after two groups of treatments, the pruritus frequency and the secondary skin damage symptom integral are evaluated according to the Chinese medicine new drug clinical research guiding principle. The pruritus area is less than or equal to 25 percent or the pruritus attack frequency is less than or equal to 2 times/d and 2 minutes is counted; the pruritus area is 25-50% or the pruritus frequency is 3-5 times/d and 4 minutes is counted; the pruritus area is more than 50 percent or the attack frequency is more than or equal to 6 times/d and is counted for 6 minutes; no skin damage meter 0 point; the skin is slightly dry, and a small amount of subcutaneous exfoliation and blood crust are counted for 2 points; moderate drying, and 4 points of flaky scale; severe dryness with obvious desquamation, with a papule and eczematoid change of 6 points. Two groups of curative effects were recorded, healing: the symptoms basically disappear, and the integral of clinical symptoms is reduced by more than 95 percent; the effect is shown: the clinical symptoms are obviously improved, and the symptom integral is reduced by 70 to 95 percent; the method has the following advantages: the clinical symptoms are improved, and the integral of the clinical symptoms is reduced by 70 to 30 percent; and (4) invalidation: the above standard is not met. The total effective is recovery + obvious effect + effective. The results are shown in Table 1.
The statistical method comprises the following steps: data were analyzed using SPSS 22.0 statistical software. Measure data to
Figure BDA0002433751440000051
Representing, adopting t test; the data of the counts are expressed in% by χ2And (6) checking. The difference is statistically significant when P is less than 0.05.
TABLE 1A, B comparison of clinical efficacy of two groups
Group of n Recovery method Show effect Is effective Invalidation Total effective rate (%)
Group A 49 10 16 13 10 79.59*
Group B 49 15 21 11 2 95.92
Note: p < 0.05 compared to group a.
As can be seen from Table 1, the total effective rate of the treatment of the group B is 95.92%, which is higher than 79.59% of the group A, and the difference has statistical significance (P is less than 0.05), which indicates that the traditional Chinese medicine composition for treating skin itch has obvious curative effect on skin itch, especially on senile skin itch with blood deficiency and wind dryness.
Example 2
A traditional Chinese medicine composition for treating skin itch comprises the following components in parts by weight: 10 parts of caulis perllae, 20 parts of tribulus terrestris, 25 parts of radix rehmanniae, 7 parts of cape jasmine, 7 parts of lophatherum gracile, 40 parts of concha haliotidis, 3 parts of coptis chinensis, 15 parts of cortex mori, 9 parts of radix ophiopogonis, 10 parts of lalang grass rhizome, 5 parts of raw rhubarb, 9 parts of schisandra chinensis, 9 parts of dark plum, 10 parts of rhizoma anemarrhenae, 7 parts of starwort root, 17 parts of phellodendron and 9 parts of raw liquorice.
The preparation of the granular formulation is prepared by the traditional Chinese medicine composition according to the following method:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water in an amount which is 10 times of the weight of the mixture, decocting for 2 hours, filtering to obtain filtrate, repeatedly decocting for 2 times, combining the filtrates, and concentrating under reduced pressure to obtain fluid extract with a relative density of 1.05 at 60 ℃ for later use;
(3) adding absolute ethanol into the fluid extract obtained in step (2) under stirring to obtain a mixture, and standing the mixture at 5 deg.C for 26h for use, wherein the volume ratio of absolute ethanol to fluid extract is 0.75: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.3 at 60 ℃ to obtain the extract of the traditional Chinese medicine composition;
(5) and (3) uniformly mixing the extract obtained in the step (4) with auxiliary materials (prepared by mixing dextrin and sugar powder according to the mass ratio of 1: 1) according to the mass ratio of 1:10, granulating by using a 14-mesh screen, drying at 60 ℃, grading by using a 10-mesh screen, and packaging by using 15g bags.
Example 3
A traditional Chinese medicine composition for treating skin itch comprises the following components in parts by weight: 20 parts of caulis perllae, 10 parts of tribulus terrestris, 15 parts of radix rehmanniae, 12 parts of cape jasmine, 15 parts of lophatherum gracile, 20 parts of concha haliotidis, 6 parts of coptis chinensis, 9 parts of cortex mori, 15 parts of radix ophiopogonis, 20 parts of lalang grass rhizome, 4 parts of raw rhubarb, 7 parts of schisandra chinensis, 8 parts of dark plum, 20 parts of rhizoma anemarrhenae, 20 parts of starwort root, 10 parts of cortex phellodendri and 3 parts of raw liquorice.
The preparation of the granular formulation is prepared by the traditional Chinese medicine composition according to the following method:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water 8 times the weight of the mixture, decocting for 1h, filtering to obtain filtrate, repeatedly decocting for 1 time, mixing the filtrates, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.02 at 60 deg.C;
(3) adding absolute ethanol into the fluid extract obtained in step (2) under stirring to obtain a mixture, and standing the mixture at 8 ℃ for 32h for later use, wherein the volume ratio of the absolute ethanol to the fluid extract is 0.65: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.2 at 60 ℃ to obtain the extract of the traditional Chinese medicine composition;
(5) and (3) uniformly mixing the extract obtained in the step (4) with auxiliary materials (prepared by mixing dextrin and sugar powder according to the mass ratio of 1: 1) according to the mass ratio of 1:10, granulating by using a 14-mesh screen, drying at 65 ℃, grading by using a 10-mesh screen, and packaging by using 15g bags.
And the granules prepared in the embodiments 2 and 3 are respectively used for clinical case curative effect analysis, and clinical tests show that the same curative effect is obvious.
Finally, the above embodiments are only intended to illustrate the technical solutions of the present invention and not to limit the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions, and all of them should be covered by the claims of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for treating skin itch is characterized by comprising the following components in parts by weight: 10-20 parts of caulis perllae, 10-20 parts of tribulus terrestris, 15-25 parts of radix rehmanniae, 5-15 parts of cape jasmine, 5-15 parts of lophatherum gracile, 20-40 parts of concha haliotidis, 3-9 parts of coptis chinensis, 5-15 parts of cortex mori, 5-15 parts of radix ophiopogonis, 10-20 parts of lalang grass rhizome, 1-5 parts of raw rhubarb, 3-9 parts of schisandra chinensis, 3-9 parts of dark plum, 10-20 parts of rhizoma anemarrhenae, 5-20 parts of starwort root, 10-20 parts of cortex phellodendri and 3-9 parts of raw liquorice.
2. The traditional Chinese medicine composition for treating skin itch according to claim 1, which comprises the following components in parts by weight: 15 parts of caulis perllae, 15 parts of tribulus terrestris, 20 parts of radix rehmanniae, 10 parts of cape jasmine, 10 parts of lophatherum gracile, 30 parts of concha haliotidis, 6 parts of coptis chinensis, 10 parts of cortex mori, 10 parts of radix ophiopogonis, 15 parts of lalang grass rhizome, 3 parts of raw rhubarb, 6 parts of schisandra chinensis, 6 parts of dark plum, 15 parts of rhizoma anemarrhenae, 10 parts of starwort root, 15 parts of cortex phellodendri and 6 parts of raw liquorice.
3. An extract of the Chinese medicinal composition for treating skin itch of claim 1 or 2.
4. The extract of the traditional Chinese medicine composition for treating skin itch as claimed in claim 3, wherein the extract is prepared by the following method:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water with the weight being 8-10 times of that of the mixture, decocting for 1-2h, filtering to obtain filtrate, repeatedly decocting for 1-2 times, combining the filtrates, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.00-1.05 at 60 deg.C for use;
(3) adding absolute ethanol into the fluid extract obtained in the step (2) under stirring to obtain a mixture, and standing the mixture at 5-8 ℃ for 24-32h for later use, wherein the volume ratio of the absolute ethanol to the fluid extract is 0.65-0.75: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.20-1.30 at 60 ℃.
5. The extract of the traditional Chinese medicine composition for treating skin itch as claimed in claim 3, wherein the extract is prepared by the following method:
(1) weighing caulis Fibraureae, fructus Tribuli, radix rehmanniae, fructus Gardeniae, folium Bambusae, Concha Haliotidis, Coptidis rhizoma, cortex Mori, radix Ophiopogonis, lalang grass rhizome, radix et rhizoma Rhei, fructus Schisandrae, mume fructus, rhizoma anemarrhenae, radix Stellariae, cortex Phellodendri, and Glycyrrhrizae radix at a certain ratio;
(2) mixing the components in the step (1), adding water 9 times the weight of the mixture, decocting for 1.5h, filtering to obtain filtrate, repeatedly decocting for 2 times, mixing the filtrates, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.00-1.05 at 60 deg.C;
(3) adding absolute ethyl alcohol into the clear paste obtained in the step (2) under stirring to obtain a mixture, and standing the mixture at 6 ℃ for 24 hours for later use, wherein the volume ratio of the absolute ethyl alcohol to the clear paste is 0.7: 1;
(4) filtering the mixture after standing in the step (3), taking the filtrate, and concentrating under reduced pressure to obtain a thick paste with the relative density of 1.20-1.30 at 60 ℃.
6. A pharmaceutical preparation comprising as an active ingredient an extract of the Chinese medicinal composition for treating skin pruritus according to any one of claims 3 to 5.
7. The pharmaceutical preparation according to claim 6, wherein the dosage form of the pharmaceutical preparation is one of, but not limited to, oral liquid, tablets and granules.
8. The pharmaceutical preparation according to claim 7, wherein the pharmaceutical preparation is prepared by the following method when the dosage form is granules:
mixing the extract of the Chinese medicinal composition for treating skin itch of any one of claims 3-5 with adjuvants, sieving with 14 mesh sieve, granulating, oven drying at 60-65 deg.C, and sieving with 10 mesh sieve.
9. The pharmaceutical preparation according to claim 8, wherein the mass ratio of the extract to the auxiliary material is 1:10, and the auxiliary material is formed by mixing dextrin and powdered sugar in a mass ratio of 1: 1.
10. Use of the traditional Chinese medicine composition for treating skin itch of claim 1 or 2 or an extract of the traditional Chinese medicine composition for treating skin itch of any one of claims 3 to 5, for the preparation of a medicament for treating skin itch.
CN202010244947.2A 2020-03-31 2020-03-31 Traditional Chinese medicine composition for treating skin itch and extract and preparation thereof Pending CN111329966A (en)

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Publication number Priority date Publication date Assignee Title
CN115919964A (en) * 2022-06-08 2023-04-07 重庆市中医院 Pharmaceutical composition for treating skin itch of hemodialysis patients and preparation method thereof

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CN105616912A (en) * 2016-04-08 2016-06-01 黄庆辉 Traditional Chinese medicine for treating toxic-heat urticaria
CN107582990A (en) * 2017-11-02 2018-01-16 郭蓉 A kind of Chinese medicine preparation and preparation method for treating herpes zoster

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Publication number Priority date Publication date Assignee Title
CN101579475A (en) * 2008-05-18 2009-11-18 尚爱永 Traditional Chinese medicine for treating eczema
CN102100840A (en) * 2009-12-17 2011-06-22 天津市中宝制药有限公司 Traditional Chinese medicine composition for treating eczema
CN102772710A (en) * 2012-07-30 2012-11-14 李承平 Cortex dictamni beauty medicinal tablet
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115919964A (en) * 2022-06-08 2023-04-07 重庆市中医院 Pharmaceutical composition for treating skin itch of hemodialysis patients and preparation method thereof
CN115919964B (en) * 2022-06-08 2023-09-22 重庆市中医院 Pharmaceutical composition for treating cutaneous pruritus of hemodialysis patient and preparation method thereof

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