CN115919964B - Pharmaceutical composition for treating cutaneous pruritus of hemodialysis patient and preparation method thereof - Google Patents

Pharmaceutical composition for treating cutaneous pruritus of hemodialysis patient and preparation method thereof Download PDF

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CN115919964B
CN115919964B CN202210638854.7A CN202210638854A CN115919964B CN 115919964 B CN115919964 B CN 115919964B CN 202210638854 A CN202210638854 A CN 202210638854A CN 115919964 B CN115919964 B CN 115919964B
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pharmaceutical composition
hemodialysis
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treating cutaneous
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CN115919964A (en
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熊维建
张太君
张玲
黎颖
骆言
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Chongqing Traditional Chinese Medicine Hospital
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Abstract

The application discloses a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis and a preparation method thereof, and solves the technical problems that the existing western medicines for treating cutaneous pruritus of end-stage renal disease have side effects and the existing external medicines have poor curative effects. The application relates to a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis, which comprises the following raw materials: lily, dried rehmannia root, rhizoma anemarrhenae, schizonepeta, clematis root, notopterygium root, elsholtzia, pricklyash peel, honeycomb, bighead atractylodes rhizome, asarum, talcum, liquorice, tuber fleeceflower stem, cinnamon, peach kernel and oyster. The application has the advantages of strong pertinence, good antipruritic effect, small side effect and the like.

Description

Pharmaceutical composition for treating cutaneous pruritus of hemodialysis patient and preparation method thereof
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating cutaneous pruritus of a hemodialysis patient and a preparation method thereof.
Background
Skin itch is one of the common complications of end stage renal disease, and studies have shown that about 37% to 46% of hemodialysis patients worldwide have more than moderate itch. The clinical characteristics are high incidence, difficult cure and repeated attack; the main clinical manifestation is itching paroxysmal onset with unequal duration, which can be relieved by oneself, and the typical occurrence parts are forehead, dorsum and palms of the forearms, and most of the skin secondary lesions are accompanied. Often accompanied by a decline in sleep quality and emotional abnormalities.
The current western medicines for treating uremia skin itch are as follows: gabapentin, naltrexone, cetirizine, astemizole, and the like. The external treatment method comprises the following steps: skin lubricant, fish oil, olive oil, ultraviolet B, capsaicin, etc. The treatment can improve the symptoms of patients to different degrees, but the external treatment method has poor treatment effect, and the symptoms of dizziness and sleepiness are abstinent after western medicines are orally taken.
According to the method for treating the skin itch of the end-stage renal disease, the side effect of the western medicine is shown by oral administration, the efficacy of the external treatment method is to be improved, and the external treatment method is easy to relapse. From the current theory of traditional Chinese medicine, the traditional Chinese medicine is used for treating the disease, and from the whole concept, dialectical treatment is another way for treating uremia skin itch.
Therefore, in order to overcome the problems of the existing western medicines and external medicines, it is necessary to develop a traditional Chinese medicine composition with good curative effect for treating uremic skin itch.
Disclosure of Invention
The technical problems to be solved by the application are as follows: the existing western medicines for treating the skin itch of the end-stage renal disease have side effects, and the existing external medicines have poor curative effects.
The application is realized by the following technical scheme:
a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis comprises the following raw materials:
lily, dried rehmannia root, rhizoma anemarrhenae, schizonepeta, clematis root, notopterygium root, elsholtzia, pricklyash peel, honeycomb, bighead atractylodes rhizome, asarum, talcum, liquorice, tuber fleeceflower stem, cinnamon, peach kernel and oyster.
Skin itch can be classified as wind itch, itchy wind, hidden rash and the like in traditional Chinese medicine. In the interior meridian, pathogenic wind is applied to the muscles, which causes the muscles to be deficient, true qi to be in the mouth, and cold to beat the skin, while the exterior striae … … is itchy. Itching is considered to be caused by weak body and defensive exterior, pathogenic wind entering the striae and striae due to pathogenic wind and blood beating on the skin.
The pathogenesis of the skin itch of the end-stage renal disease is complex, belongs to the categories of 'kidney fatigue', 'consumptive disease', 'Guangge', 'drowning toxin' and the like in the traditional Chinese medicine, and the basic pathogenesis is lung-spleen-kidney deficiency, damp turbidity and toxin accumulation, and skin malnutrition, dyspnea and damp-heat turbidity and toxin blocking caused by viscera deficiency are important factors for aggravating the skin itch.
Based on the pathogenesis, the application mainly takes the effects of blood deficiency and wind dryness, lung-spleen-kidney deficiency and damp turbidity and toxin accumulation as the main treatment of dispelling wind and relieving itching, clearing heart fire and moistening lung, strengthening spleen and eliminating dampness and the like.
In the pharmaceutical composition of the application, lily is sweet and cold, enters lung and heart channels, moistens lung and clears heart and calms nerves, and the method comprises the following steps: clearing phlegm fire and tonifying deficiency; the rehmannia root is sweet, bitter and cold in nature, enters heart, liver and kidney meridians, clears heat and cools blood, nourishes yin and engenders liquid; rhizoma anemarrhenae is bitter and cold in nature, nourishes yin and reduces pathogenic fire; schizonepeta nature warm, main cold and heat, dispelling wind and relieving exterior syndrome; the radix clematidis is pungent and warm in nature, and has the effects of dispelling wind, dredging collaterals and relieving pain; notopterygium root has the effects of dispelling cold and relieving pain; herba Moslae has effects of relieving exterior syndrome, eliminating dampness, and warming middle warmer; zanthoxylum bungeanum Maxim has the effects of dispelling cold and dampness, warming middle-jiao and relieving pain; the nidus Vespae has effects of killing parasite, dispelling pathogenic wind, and eliminating dampness; the bighead atractylodes rhizome has the effects of tonifying spleen, strengthening exterior, eliminating dampness and promoting diuresis; asarum herb warms lung, dispels cold, dispels wind and relieves pain; talc has effects of clearing heat and astringing; licorice root, radix Glycyrrhizae Praeparata has effects of moistening lung, invigorating spleen, relieving spasm and pain; the tuber fleeceflower stem has the effects of nourishing heart, soothing nerves, dredging collaterals and dispelling wind; cinnamon dispels cold and warms and dredges meridians; semen Persicae has effects of removing blood stasis, promoting diuresis and relieving pain; oyster shell, concha Ostreae, has effects of softening and resolving hard mass, astringing and consolidating constitution.
The principle of monarch, minister, assistant and guide is as follows:
and (3) a monarch: lily bulb and dried rehmannia root
All sores and sores belong to heart, the lung is mainly fur, the lily is used for heart and lung, clearing heart and soothing nerves, nourishing yin and moistening lung; the dried rehmannia root is used for heart, liver and kidney, clearing heat and cooling blood, nourishing yin, taking lily as a monarch, nourishing yin and blood, moistening dryness and dispelling wind.
Minister: rhizoma anemarrhenae, notopterygii rhizoma, atractylodis rhizoma, herba Moslae, pulvis Talci, herba Schizonepetae, radix Clematidis, concha Ostreae, and semen Persicae
Rhizoma anemarrhenae: nourishing yin to reduce pathogenic fire; notopterygium root: dispelling wind and cold; atractylodis rhizoma, herba Moslae, and pulvis Talci: strengthening spleen and eliminating dampness; herba schizonepetae: dispelling wind and relieving exterior syndrome; radix clematidis and oyster: softening hardness to dissipate stagnation and dispelling wind; peach kernel: promoting blood circulation to remove blood stasis.
And (3) adjuvant: fructus Zanthoxyli, herba asari, cortex Cinnamomi, nidus Vespae and caulis Polygoni Multiflori
Pricklyash peel, asarum herb and cinnamon: dispelling cold and relieving pain; honeycomb: killing insects and dispelling wind; caulis Polygoni Multiflori: tranquillizing;
and (3) enabling the mixture to be subjected to the following steps: licorice root
Licorice root, radix Glycyrrhizae Praeparata, which is used for relieving pain and regulating the functions of the medicines.
Compared with the prior art, the traditional Chinese medicine composition has the effects of warming the middle-jiao, dispelling cold, cooling blood, dispelling wind, dredging collaterals, treating both lung, spleen and kidney, promoting the medicine to permeate skin, dispersing from lung, dredging and descending from intestine and the like, so that the curative effect is improved. The patient has emotional changes and insomnia. The radix rehmanniae preparata not only nourishes heart and lung, but also clears qi and blood heat to calm the mind and synergistically improve the symptoms of patients. The Chinese prickly ash and honeycomb are specific pesticide for killing insects and dispelling itch, and the medicine has good curative effect for treating skin itch, and has no obvious side effect and adverse reaction.
The application discloses a medicine composition for treating cutaneous pruritus of a patient with hemodialysis, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the application discloses a medicine composition for treating cutaneous pruritus of a patient with hemodialysis, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the application discloses a medicine composition for treating cutaneous pruritus of a patient with hemodialysis, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the medicine is in the form of granule or decoction.
A preparation method of a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis comprises the following steps:
step 1: mixing the Chinese medicinal materials with 2-4 times of water, and soaking to obtain medicinal mixture;
step 2: boiling the medicine mixture obtained in the step 1;
step 3: slowly decocting the medicine mixture boiled in the step 2 with small fire for 20-60min;
step 4: and (3) standing and filtering the medicine obtained by the slow decoction in the step (3) to obtain the medicine decoction.
The application relates to a preparation method of a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis, which is characterized in that in the step 1, the soaking time is 30-60min.
The application relates to a preparation method of a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis, which is characterized in that in the step 2, the patient is boiled for 5-10min and then turns into small fire.
The application discloses a preparation method of a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis, wherein in the step 3, the slow decoction time of small fire is 30min.
The application preferably provides a preparation method of a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis, wherein in the step 4, the pore diameter of a filter screen adopted for filtering is 0.5-1mm.
The application has the following advantages and beneficial effects:
1. the application starts from pathogenesis of skin itch of end-stage renal disease, adopts the synergistic effect between the combination of the monarch, minister, assistant and guide raw materials of different traditional Chinese medicinal materials, and prepares the traditional Chinese medicinal composition with good curative effect and small side effect aiming at the skin itch of end-stage renal disease.
2. The traditional Chinese medicine composition disclosed by the application has the effects of warming the middle-jiao to dispel cold, cooling blood, dispelling wind and dredging collaterals, treating both lung, spleen and kidney, promoting the medicine to permeate the skin, dispersing from the lung, dredging from the intestine and the like, so that the curative effect is improved. The patient has emotional changes and insomnia. The radix rehmanniae preparata not only nourishes heart and lung, but also clears qi and blood heat to calm the mind and synergistically improve the symptoms of patients. The Chinese prickly ash and honeycomb are specific pesticide for killing insects and dispelling itch, and have the effect of improving other symptoms while treating skin itch.
3. The traditional Chinese medicine composition can be prepared into various dosage forms, and is simple to prepare and convenient to take orally.
Detailed Description
The present application will be described in further detail with reference to the following examples, for the purpose of making the objects, technical solutions and advantages of the present application more apparent, and the description thereof is merely illustrative of the present application and not intended to be limiting.
Example 1
1. The traditional Chinese medicine raw materials are prepared according to the following weight:
30 parts of lily, 30 parts of dried rehmannia root, 30 parts of rhizoma anemarrhenae, 40 parts of schizonepeta, 30 parts of radix clematidis, 30 parts of notopterygium root, 30 parts of elsholtzia, 30 parts of pepper, 30 parts of honeycomb, 40 parts of bighead atractylodes rhizome, 15 parts of asarum, 30 parts of talcum, 30 parts of liquorice, 30 parts of tuber fleeceflower stem, 30 parts of cinnamon, 30 parts of peach seed and 30 parts of oyster.
2. The preparation process comprises the following steps:
mixing the above raw materials, adding appropriate amount of water, extracting for 2 times by decocting, filtering, and mixing the 2 filtrates.
Step 1: mixing the traditional Chinese medicine raw materials with 4 times of water by volume, and soaking to obtain a medicine mixture;
step 2: boiling the medicine mixture obtained in the step 1 for 5min;
step 3: decocting the medicine mixture obtained in the step 2 for 5min with slow fire for 30min;
step 4: filtering with 1mm filter screen to obtain primary medicinal filtrate;
step 5: adding 3 times of water into the filtered residues, continuously boiling for 5min, and decocting for 20min.
Step 6: filtering to obtain secondary medicine filtrate;
step 7: and combining the primary medicine filtrate and the secondary medicine filtrate to obtain the final medicine decoction.
Example 2
The difference between this example and example 1 is that the amounts of the raw materials of the Chinese medicinal materials are different as follows:
example 3
The difference between this example and example 1 is that the amounts of the raw materials of the Chinese medicinal materials are different as follows:
clinical trials
To demonstrate the efficacy and safety of the drug of the present application, the inventors conducted 60 clinical observations. The research method and test results adopted are as follows:
1. general data: 60 patients with cutaneous refractory itching were selected.
2. Inclusion criteria: 1) All cases meet the clinical practice guidelines for chronic kidney disease and dialysis (2002 edition) phase 5 diagnosis of chronic kidney disease and begin to receive hemodialysis patients. 2) Meets the diagnosis standard of intractable skin itch, namely that the skin itch lasts for more than 3 months and is accompanied with systemic skin change, and the external medicine, the physiotherapy and the like are adopted, so that the curative effect is poor, and the work and the life of the skin itch are seriously influenced.
3. Exclusion criteria: 1) Skin itch caused by drug allergy and dermatological diseases; 2) For various reasons, study or interviewee cannot be completed in a matched manner; 3) Is suitable for patients suffering from allergy to traditional Chinese medicine.
4. The treatment method comprises the following steps: the traditional Chinese medicine composition described in the embodiment 1 of the application (the traditional Chinese medicine composition is used on the basis of conventional dialysis treatment) is used by adopting the front-back control of the traditional Chinese medicine composition, and one dose is used daily, and fumigation and scrubbing are carried out. Simultaneously, the following conventional treatment methods are matched: 1) Regular hemodialysis 2) primary disease treatment: lowering blood pressure, correcting blood sugar, treating secondary hyperthyroidism, etc. The observation period was 2 months.
5. And (3) observing the indexes: integral of the degree of itching
DirkR.Kuypers uremia skin itch scoring method
Itching degree integral quantization table
Mild (4-6 min), moderate (7-9 min), severe (10-12 min), severe (> 12 min)
In the uremia skin itch degree integral quantification table, 4 symptoms are adopted to characterize the itch degree, the total integral sum of 4 items is the total integral, in general judgment, the total integral is judged to be mild in 4-6 points, the total integral is judged to be moderate in 7-9 points, the total integral is judged to be severe in 10-12 points, and the total integral is more than 12 points to be extremely severe.
6. And (3) judging curative effect: the percent reduction integrated by the degree of kuypers itching was judged as three grades, significant, effective, and ineffective, according to the clinical dirkr.
[ (pre-treatment integral-post-treatment integral)/(pre-treatment integral ] ×100%).
(1) The effect is shown: the total integral score of the pruritus degree is reduced by more than or equal to 50 percent.
(2) The method is effective: the total integral score of the pruritus degree is reduced by more than or equal to 30 percent, but less than 50 percent.
(3) Invalidation: and not reaching the effective standard or aggravating.
Total effective rate = [ (number of significant cases+number of significant cases)/(total cases ] ×100%).
Adverse reaction observation: including neurological abnormalities, skin allergies, etc.
Statistical methods: SPSS17 statistical software analysis is adopted, t test is adopted for metering data, and χ is adopted for counting data 2 Checking the P value<0.05 indicates that the difference is statistically significant.
Results
Symptom score of patient's itching degree before and after treatment (x.+ -.s)
Time N Mild and mild Moderate degree Heavy weight Extremely heavy (x±s)
Before treatment 60 2 13 35 10 11.12±2.22
After treatment 60 17 36 7 0 6.93±1.60
Efficacy assessment
N Has obvious effect Effective and effective Invalidation of Effective rate is%
Degree of itching 60 9 45 6 90
The symptom integral statistics before and after treatment are as follows: the drug group of the application has 9 cases of obvious effects, 45 cases of effective cases and 6 cases of ineffective cases; the total effective rate is 90 percent. No obvious adverse reaction is seen in the process of administration. P value <0.05.
7. Typical medical history:
(1) Name: leaf xx, male, age 70. And maintaining the sexual hemodialysis for 5+years and the skin itching for 1+years. The patient starts regular hemodialysis treatment due to uremia 4 years ago, and the disease condition is stable during the dialysis period. The skin itch of the whole body does not appear due to obvious causes before 1+ years, the night is very light, the dysphoria is caused, the dialysis is enhanced, and the effect is poor when the loratadine medicament and the traditional Chinese medicine are used for treatment. Blood test routine shows: 104g/L hemoglobin, and white blood cells 6.9x10 9 L, N72.8%; parathyroid hormone 305.4pg/ml; phosphorus 1.3mmol/L. The following symptoms are shown in the following formula: itching in the whole body, obvious scratches are visible on the whole body, the skin is dry and rough, red pimples are scattered on the skin, and the tongue is dark red and thin in coating. Diagnosis of traditional Chinese medicine: itching, deficiency of the liver and kidney, and accumulation of damp-toxin. Prescription: 30 parts of lily, 30 parts of dried rehmannia root, 30 parts of rhizoma anemarrhenae, 40 parts of schizonepeta, 30 parts of radix clematidis, 30 parts of notopterygium root, 30 parts of elsholtzia, 30 parts of pepper, 30 parts of honeycomb, 40 parts of bighead atractylodes rhizome, 15 parts of asarum, 30 parts of talcum, 30 parts of liquorice, 30 parts of tuber fleeceflower stem, 30 parts of cinnamon, 30 parts of peach seed and 30 parts of oyster. 5 doses of water is added into 2L of water for decoction, the place with obvious itch is fumigated while the place is hot, then the place is cooled to about 35 ℃, the skin of an affected part is completely soaked in the liquid medicine or is rubbed and washed for 30 min/time, and then the skin of the affected part is washed with clear water for 2 times/d. The itch of skin is obviously relieved after the use, and the dryness of skin is relieved.
(2) Name: sweet xx, male, 63 years old. And maintaining the sexual hemodialysis for 2+years, and skin itching for 4+month. The patient starts regular hemodialysis treatment due to uremia 2 years ago, and the disease condition is stable during the dialysis period. The skin itch of the whole body does not appear due to obvious causes before 4+ months, the night is aggravated, the dysphoria can not sleep, and the effect is poor when the anti-allergic or traditional Chinese medicine liniment is used for treatment. Blood test routine shows: hemoglobin 93g/L, white blood cell 6.08x10 9 L, N59%; parathyroid hormone 263.3pg/ml; phosphorus 1.08mmol/L. The following symptoms are shown in the following formula: itching in the chest and abdomen, obvious scratches, pigmentation, scab, dry skin, dark red tongue and white coating are seen. Diagnosis of traditional Chinese medicine: itching, deficiency of the liver and kidney, and accumulation of damp-toxin. Prescription: 30 parts of lily, 30 parts of dried rehmannia root, 30 parts of rhizoma anemarrhenae, 40 parts of schizonepeta, 30 parts of radix clematidis, 30 parts of notopterygium root, 30 parts of elsholtzia, 30 parts of pepper, 30 parts of honeycomb, 40 parts of bighead atractylodes rhizome, 15 parts of asarum, 30 parts of talcum, 30 parts of liquorice, 30 parts of tuber fleeceflower stem, 30 parts of cinnamon, 30 parts of peach seed and 30 parts of oyster. 5 doses of water is added into 2L of water for decoction, the place with obvious itch is fumigated while the place is hot, then the place is cooled to about 35 ℃, the skin of an affected part is completely soaked in the liquid medicine or is rubbed and washed for 30 min/time, and then the skin of the affected part is washed with clear water for 2 times/d. The skin itch is obviously relieved after the use, and the night sleep is possible.
(3) Name: beam xx, male, 74 years old. And maintaining the sexual hemodialysis for 3+years, and skin itching for 3+months. The patient starts regular hemodialysis treatment due to uremia 3 years ago, and the disease condition is stable during the dialysis period. No obvious cause of systemic skin itch appears before 3+ months. Blood test routine shows: hemoglobin 106g/L, white blood cell 4.57x10 9 L, N59%; 245.6pg/ml parathyroid hormone; phosphorus 1.88mmol/L. The following symptoms are shown in the following formula: itching of the skin, affecting the chest and back of the extremities, visible scab and moss-like changes of the skin, scattered in the red pimples. A red tongue with greasy coating. Diagnosis of traditional Chinese medicine: itching, deficiency of the liver and kidney, and accumulation of damp-toxin. Prescription: 30 parts of lily, 30 parts of dried rehmannia root, 30 parts of rhizoma anemarrhenae, 40 parts of schizonepeta, 30 parts of radix clematidis, 30 parts of notopterygium root, 30 parts of elsholtzia, 30 parts of pepper, 30 parts of honeycomb, 40 parts of bighead atractylodes rhizome, 15 parts of asarum, 30 parts of talcum, 30 parts of liquorice, 30 parts of tuber fleeceflower stem, 30 parts of cinnamon, 30 parts of peach seed and 30 parts of oyster. 7 agents, adding 2L of water, decocting, fumigating the obvious itching place while the agent is hot, cooling to about 35 ℃, completely soaking the skin of an affected part in the liquid medicine or wiping the skin for 30 min/time, and then washing the skin of the affected part with clear water for 2 times/d. After the use, the skin itch of the patient disappears.
The clinical experiment results show that the traditional Chinese medicine composition has obvious effect in treating skin pruritus of hemodialysis patients.
The foregoing description of the embodiments has been provided for the purpose of illustrating the general principles of the application, and is not meant to limit the scope of the application, but to limit the application to the particular embodiments, and any modifications, equivalents, improvements, etc. that fall within the spirit and principles of the application are intended to be included within the scope of the application.

Claims (9)

1. The pharmaceutical composition for treating cutaneous pruritus of a patient suffering from hemodialysis is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight:
23-37 parts of lily, 23-37 parts of dried rehmannia root, 23-37 parts of rhizoma anemarrhenae, 30-57 parts of schizonepeta, and the like
23-37 parts of radix clematidis, 23-37 parts of notopterygium root, 23-37 parts of elsholtzia, 23-37 parts of pepper and 23-37 parts of
23-37 parts of honeycomb, 30-57 parts of bighead atractylodes rhizome, 10-25 parts of asarum, 23-37 parts of talcum
23-37 parts of liquorice, 25-35 parts of tuber fleeceflower stem, 25-35 parts of cinnamon, 23-37 parts of peach seed
23-37 parts of oyster, wherein the drug composition is administered by the following modes: fumigating and scrubbing.
2. The pharmaceutical composition for treating cutaneous pruritus of hemodialysis patients according to claim 1, wherein the raw materials of the traditional Chinese medicinal materials are prepared from the following components in parts by weight:
25-35 parts of lily, 25-35 parts of dried rehmannia root, 25-35 parts of rhizoma anemarrhenae, 35-55 parts of herba schizonepetae
25-35 parts of radix clematidis, 25-35 parts of notopterygium root, 25-35 parts of elsholtzia, 25-35 parts of pepper and 25-35 parts of
25-35 parts of honeycomb, 35-55 parts of bighead atractylodes rhizome, 10-25 parts of asarum herb, 25-35 parts of talcum
25-35 parts of liquorice, 25-35 parts of tuber fleeceflower stem, 25-35 parts of cinnamon, 25-35 parts of peach seed and 25-35 parts of peach seed
Oyster 25-35 parts.
3. The pharmaceutical composition for treating cutaneous pruritus of hemodialysis patients according to claim 1 or 2, wherein the raw materials of the traditional Chinese medicinal materials are prepared from the following components in parts by weight:
30 parts of lily, 30 parts of dried rhizome of rehmannia, 30 parts of anemarrhena rhizome, 40 parts of schizonepeta herb
30 parts of radix clematidis, 30 parts of notopterygium root, 30 parts of elsholtzia herb and 30 parts of pepper
30 parts of honeycomb, 40 parts of bighead atractylodes rhizome, 15 parts of asarum herb and 30 parts of talcum
30 parts of liquorice, 30 parts of tuber fleeceflower stem, 30 parts of cinnamon, 30 parts of peach seed
30 parts of oyster.
4. The pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis according to claim 1 or 2, wherein the pharmaceutical dosage form is a granule or decoction.
5. A preparation method of a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis, which is characterized by comprising the following steps:
step 1: mixing and soaking the traditional Chinese medicine raw materials in any one of claims 1-3 with 2-4 times of water to obtain a medicine mixture;
step 2: boiling the medicine mixture obtained in the step 1;
step 3: slowly decocting the medicine mixture boiled in the step 2 with small fire for 20-60min;
step 4: and (3) standing and filtering the medicine obtained by the slow decoction in the step (3) to obtain the medicine decoction.
6. The method for preparing a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis according to claim 5, wherein the soaking time in the step 1 is 30-60min.
7. The method for preparing a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis according to claim 5 or 6, wherein in the step 2, the boiling is continued for 5-10min and then the fire is turned to be small.
8. The method for preparing a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis according to claim 5 or 6, wherein in the step 3, the slow decoction time with slow fire is 30min.
9. The method for preparing a pharmaceutical composition for treating cutaneous pruritus of a patient with hemodialysis according to claim 5 or 6, wherein in the step 4, the pore size of the filter screen used for filtering is 0.5-1mm.
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