CN1539491A - Chinese traditional medicine for upper respiratory tract infection - Google Patents
Chinese traditional medicine for upper respiratory tract infection Download PDFInfo
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- CN1539491A CN1539491A CNA2003101108227A CN200310110822A CN1539491A CN 1539491 A CN1539491 A CN 1539491A CN A2003101108227 A CNA2003101108227 A CN A2003101108227A CN 200310110822 A CN200310110822 A CN 200310110822A CN 1539491 A CN1539491 A CN 1539491A
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- ethanol
- extract powder
- water
- tablet
- extract
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- 239000003814 drug Substances 0.000 title claims abstract description 30
- 206010057190 Respiratory tract infections Diseases 0.000 title claims description 9
- 206010046306 Upper respiratory tract infection Diseases 0.000 title claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 91
- 239000002775 capsule Substances 0.000 claims abstract description 13
- 239000003826 tablet Substances 0.000 claims abstract description 13
- 239000006187 pill Substances 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 39
- 239000000843 powder Substances 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 27
- 238000000605 extraction Methods 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 17
- 238000010828 elution Methods 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 239000007962 solid dispersion Substances 0.000 claims description 12
- 238000001291 vacuum drying Methods 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 11
- 235000008504 concentrate Nutrition 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 9
- 239000004925 Acrylic resin Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 229940046011 buccal tablet Drugs 0.000 claims description 6
- 239000006189 buccal tablet Substances 0.000 claims description 6
- 239000000969 carrier Substances 0.000 claims description 6
- 229940068682 chewable tablet Drugs 0.000 claims description 6
- 239000007910 chewable tablet Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 239000006196 drop Substances 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229940023488 pill Drugs 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 6
- 229920003134 Eudragit® polymer Polymers 0.000 claims description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 4
- 239000003463 adsorbent Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000008394 flocculating agent Substances 0.000 claims description 3
- 235000014666 liquid concentrate Nutrition 0.000 claims description 3
- -1 reflux Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 210000002345 respiratory system Anatomy 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000735332 Gerbera Species 0.000 abstract 1
- 244000197975 Solidago virgaurea Species 0.000 abstract 1
- 235000000914 Solidago virgaurea Nutrition 0.000 abstract 1
- 230000001055 chewing effect Effects 0.000 abstract 1
- 238000000151 deposition Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of capsule, particle, tablet, chewing tablet, or dripping pill for treating infection of upper respiratory tract is prepared from 3 Chinese-medicinal materials including honeysuckle flower, pilose gerbera herb and golden rod herb through decocting, depositing in alcohol, extracting and concentrating.
Description
Technical field: the present invention relates to treat the Chinese medicine of upper respiratory tract infection, particularly a kind of Chinese medicine preparation for the treatment of upper respiratory tract infection.
Background technology: prior art is to Treatment of Upper Respiratory Tract Infection, Western medicine uses antibiotics more, these class medicine great majority only work to gram positive bacteria, to the gram negative bacteria weak effect, invalid to the respiratory tract Causative virus, take for a long time and can develop immunity to drugs, easily cause the disorder of human body normal microflora, hepatic renal dysfunction patient forbidding.How Chinese medicine preparation is directly made with crude drug decocting Stewed Dish, and dose is big, and effective site is imprecise, directly influences the drug effect performance.
Summary of the invention: the objective of the invention is to: a kind of Chinese medicine preparation for the treatment of upper respiratory tract infection is provided, and it can reach heat-clearing and toxic substances removing, the purpose of lung qi dispersing cough-relieving.
Formation of the present invention: it is made up of the material medicine of following consumption: Flos Lonicerae 1200～1500 grams, Herba Solidaginis 1200～1500 grams, Herba Gerberae Piloselloidis 1000～1200 grams.
Preparation technology 1, with Herba Solidaginis, Herba Gerberae Piloselloidis is cataclasm, and the back decocts 3 times with the Flos Lonicerae water, each 10～12 times of amounts of water, decocting time the 1st time 2 hours, the 2nd, 3 times each 1 hour, filter merging filtrate, being concentrated into relative density is 1.08,60 ℃, add ethanol, make that to contain amount of alcohol be 65%, left standstill 48 hours, filter, filtrate recycling ethanol concentrates and records the fluid extract that relative density is 1.10-1.18 when obtaining 25 ℃, with water saturated n-butanol extraction fluid extract, combining extraction liquid reclaims n-butyl alcohol, spray-dried or vacuum drying, obtain extract powder, make capsule with extract powder, granule, tablet, buccal tablet; Or be the solid dispersion of preparing carriers extract powder with polyacrylic resin Eudragit II number or III number, polyethylene glycol 6000-10000, proportioning is a medicine: carrier is 1: 3-1: 10.The technology of preparation solid dispersion is: be dissolved in extract powder and carrier in the ethanol respectively, slowly join the medicine alcoholic solution in the carrier solution, fully mix, ethanol is removed in distilling under reduced pressure, when being evaporated to thickness, and rapid cooling curing, dry, pulverize, sieve, make enteric solubility or gastric solubility capsule, granule, tablet, chewable tablet, drop pill.
Preparation technology 2, take by weighing Herba Solidaginis, Herba Gerberae Piloselloidis, Flos Lonicerae respectively, extract respectively, and Herba Solidaginis is cataclasm, add 10-12 times of water gaging at every turn, decoct 3 times, and decocting time is 2,1,1 hour.Filter, merging filtrate, it is 1.08 that filtrate is concentrated into relative density, 60 ℃, add ethanol, make that to contain the alcohol amount be 65%, left standstill 48 hours, and filtered filtrate recycling ethanol, concentrate and record the fluid extract that relative density is 1.10-1.18 when obtaining 25 ℃, with water saturated n-butanol extraction fluid extract, combining extraction liquid, reclaim n-butyl alcohol, spray-dried or vacuum drying obtains extract powder 1.Herba Gerberae Piloselloidis is cataclasm, add 10-12 times of water gaging at every turn and decoct 3 times, decocting time is 2,1,1 hour.Filter, merging filtrate, it is 1.05,40 ℃ that filtrate is concentrated into relative density, adds clarifier or flocculating agent, fully stirs, and leaves standstill 48 hours, filters, the spray-dried or vacuum drying of filtrate obtains extract powder 2.Flos Lonicerae is added 10-12 at every turn doubly measure 50-90% ethanol, reflux, extract, 3 times refluxed 1 hour at every turn, filter, merging filtrate reclaims ethanol, being concentrated into relative density is 1.08,25 ℃, through the macroporous adsorbent resin bolt, water, 10-90% ethanol elution are collected water elution liquid and ethanol elution respectively successively, and water elution liquid concentrates back water saturation n-butanol extraction, combining extraction liquid, reclaim n-butyl alcohol,, obtain extract powder 3-1 through vacuum drying.Ethanol elution reclaims ethanol, concentrates, and spray-dried or pneumatic conveying drying obtains extract powder 3-2.Merge extract powder 1,2,3-1,3-2, make capsule, granule, tablet, buccal tablet with extract powder; Or be the solid dispersion of preparing carriers extract powder with polyacrylic resin EudragitII number or III number, polyethylene glycol 6000-10000, proportioning is a medicine: carrier is 1: 3-1: 10.The technology of preparation solid dispersion is: be dissolved in extract powder and carrier in the ethanol respectively, slowly join the medicine alcoholic solution in the carrier solution, fully mix, ethanol is removed in distilling under reduced pressure, when being evaporated to thickness, and rapid cooling curing, dry, pulverize, sieve, make enteric solubility or gastric solubility capsule, granule, tablet, chewable tablet, drop pill.
Compared with the prior art, the present invention has the effect suitable with antibiotics, especially gram negative bacteria is had stronger inhibitory action and antivirus action.Bring down a fever except that having, the antitussive, antiphlogistic effect, by the integral body conditioning of human body, clear dredging taken into account, QI and blood is also controlled, the cool completely effect of table, heat-clearing and toxic substances removing, lung qi dispersing cough-relieving of the suffering of building together, toxic and side effects is little.
The present invention be advantageous in that production technology and dosage form are comparatively advanced, taking dose is little, prepares multiple dosage form, to adapt to different patient crowds' needs, is a kind of good medicine that traditional medicine is combined with the modern pharmaceutical technology.
The specific embodiment: embodiment 1. is with Herba Solidaginis 1200 grams, the cataclasm back of Herba Gerberae Piloselloidis 1000 grams restrains water with Flos Lonicerae 1200 and decocts 3 times, each water 10-12 doubly measures, decocting time the 1st time 2 hours, the 2nd, 3 times each 1 hour, filter, merging filtrate, being concentrated into relative density is 1.08,60 ℃, add ethanol, make that to contain amount of alcohol be 65%, left standstill 48 hours, filter, filtrate recycling ethanol, concentrate when obtaining 25 ℃ and record the fluid extract that relative density is 1.10-1.18, with water saturated n-butanol extraction fluid extract, combining extraction liquid, reclaim n-butyl alcohol, spray-dried or vacuum drying obtains extract powder, makes capsule with extract powder, granule, tablet, buccal tablet; Or be the solid dispersion of preparing carriers extract powder with polyacrylic resin Eudragit II number or III number, polyethylene glycol 6000-10000, proportioning is a medicine: carrier is 1: 3-1: 10.The technology of preparation solid dispersion is: be dissolved in extract powder and carrier in the ethanol respectively, slowly join the medicine alcoholic solution in the carrier solution, fully mix, ethanol is removed in distilling under reduced pressure, when being evaporated to thickness, and rapid cooling curing, dry, pulverize, sieve, make enteric solubility or gastric solubility capsule, granule, tablet, chewable tablet, drop pill.
Embodiment 2. takes by weighing Herba Solidaginis 1500 grams respectively, Herba Gerberae Piloselloidis 1200 grams, Flos Lonicerae 1500 grams extract respectively, and Herba Solidaginis is cataclasm, add 10-12 times of water gaging at every turn, decoct 3 times, decocting time is 2,1,1 hour, filter, merging filtrate, it is 1.08,60 ℃ that filtrate is concentrated into relative density, adds ethanol, make that to contain alcohol amount be 65%, left standstill 48 hours, and filtered filtrate recycling ethanol, concentrate and record the fluid extract that relative density is 1.10-1.18 when obtaining 25 ℃, with water saturated n-butanol extraction fluid extract, combining extraction liquid, reclaim n-butyl alcohol, spray-dried or vacuum drying obtains extract powder 1; Herba Gerberae Piloselloidis is cataclasm, add 10-12 times of water gaging at every turn and decoct 3 times, decocting time is 2,1,1 hour, filter, it is 1.05,40 ℃ that merging filtrate, filtrate are concentrated into relative density, add clarifier or flocculating agent, fully stir, left standstill 48 hours, filter, spray-dried or the vacuum drying of filtrate obtains extract powder 2; Flos Lonicerae is added 10-12 at every turn doubly measure 50-90% ethanol, reflux, extract, 3 times refluxed 1 hour at every turn, filter, merging filtrate reclaims ethanol, being concentrated into relative density is 1.08,25 ℃, through the macroporous adsorbent resin bolt, water, 10-90% ethanol elution are collected water elution liquid and ethanol elution respectively successively, and water elution liquid concentrates back water saturation n-butanol extraction, combining extraction liquid, reclaim n-butyl alcohol,, obtain extract powder 3-1 through vacuum drying; Ethanol elution reclaims ethanol, concentrates, and spray-dried or pneumatic conveying drying obtains extract powder 3-2, merges extract powder 1,2,3-1,3-2, makes capsule, granule, tablet, buccal tablet with extract powder; Or be the solid dispersion of preparing carriers extract powder with polyacrylic resin Eudragit II number or III number, polyethylene glycol 6000-10000, proportioning is a medicine: carrier is 1: 3-1: 10.The technology of preparation solid dispersion is: be dissolved in extract powder and carrier in the ethanol respectively, slowly join the medicine alcoholic solution in the carrier solution, fully mix, ethanol is removed in distilling under reduced pressure, when being evaporated to thickness, and rapid cooling curing, dry, pulverize, sieve, make enteric solubility or gastric solubility capsule, granule, tablet, chewable tablet, drop pill.
Claims (3)
1. Chinese medicine preparation for the treatment of upper respiratory tract infection, it is characterized in that: it is made up of the material medicine of following consumption: Flos Lonicerae 1200～1500 grams, Herba Solidaginis 1200～1500 grams, Herba Gerberae Piloselloidis 1000～1200 grams.
2. a kind of Chinese medicine preparation for the treatment of upper respiratory tract infection according to claim 1, it is characterized in that: preparation technology 1, with Herba Solidaginis, Herba Gerberae Piloselloidis is cataclasm, and the back decocts 3 times with the Flos Lonicerae water, each 10～12 times of amounts of water, decocting time the 1st time 2 hours, the 2nd, 3 times each 1 hour, filter, merging filtrate, being concentrated into relative density is 1.08,60 ℃, add ethanol, make that to contain amount of alcohol be 65%, left standstill 48 hours, filter, filtrate recycling ethanol, concentrate when obtaining 25 ℃ and record the fluid extract that relative density is 1.10-1.18, with water saturated n-butanol extraction fluid extract, combining extraction liquid, reclaim n-butyl alcohol, spray-dried or vacuum drying obtains extract powder, makes capsule with extract powder, granule, tablet, buccal tablet; Or be the solid dispersion of preparing carriers extract powder with polyacrylic resin Eudragit II number or III number, polyethylene glycol 6000-10000, proportioning is a medicine: carrier is 1: 3-1: 10, the technology of preparation solid dispersion is: be dissolved in extract powder and carrier in the ethanol respectively, slowly join the medicine alcoholic solution in the carrier solution, fully mix, ethanol is removed in distilling under reduced pressure, when being evaporated to thickness, rapid cooling curing, dry, pulverize, sieve, make enteric solubility or gastric solubility capsule, granule, tablet, chewable tablet, drop pill.
3. a kind of Chinese medicine preparation for the treatment of upper respiratory tract infection according to claim 1, it is characterized in that: preparation technology 2, take by weighing Herba Solidaginis respectively, Herba Gerberae Piloselloidis, Flos Lonicerae, extract respectively, Herba Solidaginis is cataclasm, add 10-12 times of water gaging at every turn, decoct 3 times, decocting time is 2,1,1 hour, filter, merging filtrate, it is 1.08,60 ℃ that filtrate is concentrated into relative density, adds ethanol, make that to contain alcohol amount be 65%, left standstill 48 hours, and filtered filtrate recycling ethanol, concentrate and record the fluid extract that relative density is 1.10-1.18 when obtaining 25 ℃, with water saturated n-butanol extraction fluid extract, combining extraction liquid, reclaim n-butyl alcohol, spray-dried or vacuum drying obtains extract powder 1; Herba Gerberae Piloselloidis is cataclasm, add 10-12 times of water gaging at every turn and decoct 3 times, decocting time is 2,1,1 hour, filter, it is 1.05,40 ℃ that merging filtrate, filtrate are concentrated into relative density, add clarifier or flocculating agent, fully stir, left standstill 48 hours, filter, spray-dried or the vacuum drying of filtrate obtains extract powder 2; Flos Lonicerae is added 10-12 at every turn doubly measure 50-90% ethanol, reflux, extract, 3 times refluxed 1 hour at every turn, filter, merging filtrate reclaims ethanol, being concentrated into relative density is 1.08,25 ℃, through the macroporous adsorbent resin bolt, water, 10-90% ethanol elution are collected water elution liquid and ethanol elution respectively successively, and water elution liquid concentrates back water saturation n-butanol extraction, combining extraction liquid, reclaim n-butyl alcohol,, obtain extract powder 3-1 through vacuum drying; Ethanol elution reclaims ethanol, concentrates, and spray-dried or pneumatic conveying drying obtains extract powder 3-2, merges extract powder 1,2,3-1,3-2, makes capsule, granule, tablet, buccal tablet with extract powder; Or be the solid dispersion of preparing carriers extract powder with polyacrylic resin EudragitII number or III number, polyethylene glycol 6000-10000, proportioning is a medicine: carrier is 1: 3-1: 10, the technology of preparation solid dispersion is: be dissolved in extract powder and carrier in the ethanol respectively, slowly join the medicine alcoholic solution in the carrier solution, fully mix, ethanol is removed in distilling under reduced pressure, when being evaporated to thickness, rapid cooling curing, dry, pulverize, sieve, make enteric solubility or gastric solubility capsule, granule, tablet, chewable tablet, drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310110822 CN1242754C (en) | 2003-10-30 | 2003-10-30 | Chinese traditional medicine for upper respiratory tract infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310110822 CN1242754C (en) | 2003-10-30 | 2003-10-30 | Chinese traditional medicine for upper respiratory tract infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1539491A true CN1539491A (en) | 2004-10-27 |
| CN1242754C CN1242754C (en) | 2006-02-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310110822 Expired - Lifetime CN1242754C (en) | 2003-10-30 | 2003-10-30 | Chinese traditional medicine for upper respiratory tract infection |
Country Status (1)
| Country | Link |
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| CN (1) | CN1242754C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329046C (en) * | 2005-09-19 | 2007-08-01 | 蓝子花 | Daoshenglian medicated liquor |
| CN104491433A (en) * | 2014-12-11 | 2015-04-08 | 李洋 | Traditional Chinese medicine composition for treating cough, preparation method and application |
| CN104523794A (en) * | 2014-12-12 | 2015-04-22 | 百花医药集团股份有限公司 | Method for preparing nose disease relieving preparation |
| CN105660951A (en) * | 2016-02-22 | 2016-06-15 | 广西梧州制药（集团）股份有限公司 | Healthcare tea for preventing and treating respiratory system diseases caused by haze and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103981062A (en) * | 2014-06-04 | 2014-08-13 | 韦美利 | Traditional Chinese medicine sugarcane wine distiller yeast |
-
2003
- 2003-10-30 CN CN 200310110822 patent/CN1242754C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329046C (en) * | 2005-09-19 | 2007-08-01 | 蓝子花 | Daoshenglian medicated liquor |
| CN104491433A (en) * | 2014-12-11 | 2015-04-08 | 李洋 | Traditional Chinese medicine composition for treating cough, preparation method and application |
| CN104523794A (en) * | 2014-12-12 | 2015-04-22 | 百花医药集团股份有限公司 | Method for preparing nose disease relieving preparation |
| CN105660951A (en) * | 2016-02-22 | 2016-06-15 | 广西梧州制药（集团）股份有限公司 | Healthcare tea for preventing and treating respiratory system diseases caused by haze and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1242754C (en) | 2006-02-22 |
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Address after: 550009 No. 296 Southwest Ring Road, Xiaohe District, Guizhou, Guiyang Patentee after: GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMACEUTICAL CO.,LTD. Address before: 550009 No. 296 Southwest Ring Road, Xiaohe District, Guizhou, Guiyang Patentee before: Guizhou Tongjitang Pharmaceutical Co.,Ltd. |
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Address after: 550009 Guiyang economic and Technological Development Zone, Guizhou Province, No. 99 Tongji Hall Patentee after: GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMACEUTICAL CO.,LTD. Address before: 550009 No. 296 Southwest Ring Road, Xiaohe District, Guizhou, Guiyang Patentee before: GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMACEUTICAL CO.,LTD. |
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Granted publication date: 20060222 |