CN102198230A - Medicinal preparation for treating infantile repeated cold and preparation method thereof - Google Patents
Medicinal preparation for treating infantile repeated cold and preparation method thereof Download PDFInfo
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- CN102198230A CN102198230A CN2010101307235A CN201010130723A CN102198230A CN 102198230 A CN102198230 A CN 102198230A CN 2010101307235 A CN2010101307235 A CN 2010101307235A CN 201010130723 A CN201010130723 A CN 201010130723A CN 102198230 A CN102198230 A CN 102198230A
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Abstract
The invention relates to a medicinal preparation for treating infantile repeated cold and improving infantile immunity, which is characterized by being prepared from purple bergenia, white sandalwood, tabasheer, lagotis brachystachy maxim, aconitum tanguticum stapf, alpine cochlearia officinalis and the like. The medicinal preparation can be prepared into oral preparations such as tablets, granules, oral liquid, syrup and the like and has the effects of clearing heat and dispelling wind and reducing phlegm and relieving cough, and the total effective rate of treating the infantile repeated cold and cough clinically is 94 percent. Adverse effects do not occur in the clinical observation process, so the medicinal preparation is an ideal medicament for treating the infantile cold.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, especially treat pharmaceutical preparation of infantile common cold and preparation method thereof, diseases such as heating, pharyngalgia, infantile recurrent common cold are all had obvious treatment and preventive effect.Its dosage form comprises common peroral dosage forms such as tablet, granule, capsule.
Background technology
Because children's's changes in temperature do not know to regulate, a little less than the fragile muscle and skin, space between skin and muscles is dredged thin, and it is not solid to defend outer function, so be easy to suffer from.Be subjected to after the disease, because of internal organs delicate, so change of disease speed, and factor such as easily the hold concurrently heap soil or fertilizer over and around the roots of folder expectorant, dyspepsia, scaring and make card feelings complexity.Card controls that still to divide wind and cold, wind heat be main.Children's's body belongs to pure sun, YANG often being in excess, and the moon is normal not enough, after the sense heresy, the change of disease is rapid, the heresy of six gas, all, entering the exterior and the interior rapidly, the same disease disease of performance the exterior and the interior from cremating. children's pulmonary body is tender young, the spleen device often has deficiency, and irritability is had a surplus, the mind timidity, after the sense heresy, symptoms such as occur folder expectorant easily, folder stagnates, and folder is frightened.
Infantile common cold seriously jeopardizes children's's health, influence father and mother's work, and infantile common cold easily repeatedly.People press for and develop good effect, and the medicine that toxic and side effects is low is treated infantile common cold.Chinese medicine, Tibetan medicine, mongolian medicine have embodied greatly advantage in this respect at present.Compare with Western medicine, the ethnic drug treatment has advantages such as comprehensively regulating, side effect is little, the reinfection rate is low.Therefore the exploitation of this medicine has great social significance.
Summary of the invention
The purpose of this invention is to provide a kind of heat clearing away, reduce phlegm, cough-relieving, the pharmaceutical preparation that has obvious curative effects for infantile common cold.Pharmacodynamic experiment shows: 3 kinds of dosage of this product all can make the thymus and the spleen weightening finish of young mice, increase the phagocytic function of mouse lymphocyte, and nonspecific immunity and specific immunity are all shown potentiation.Mice serum hemolysin measurement result shows that this product can increase serum hemolysin, and humoral immune function is had potentiation.Acute toxicity test and long term toxicity test result show that all this preparation safety is nontoxic.
The invention belongs to a kind of pharmaceutical preparation of removing heat-phlegm; it is characterized in that forming, comprise 3～6 parts of Rhizoma Seu Herba Bergeniaes, 6～9 parts of Santalum albums, 6～9 parts of Concretio Silicea Bambusaes, 6～9 parts of Lagotis brachystachya Maxim.s, 6～9 parts of Tangut aconite, 3～6 parts of high mountain Radix Cochleariae officinalis dishes, 0.3～0.6 part of artificial Calculus Bovis by the medicament composing prescription of removing heat-phlegm.
Technical scheme of the present invention is: the medical material of respectively distinguishing the flavor of among the present invention is extracted, collect volatile oil, medicinal liquid is condensed into thick paste, be dried to dry powder after, can be made into oral formulations such as tablet, granule by adding different auxiliary material.The different auxiliary material that adds in the different dosage form among the present invention does not influence clinical effectiveness of the present invention, and these adjuvants comprise starch, dextrin, sucrose etc.The present invention can satisfy the demand of infantile common cold patient to different dosage form.
Characteristics of the present invention and effect are: utilization we treatment infantile common cold 150 examples of coughing, be divided into treatment group 100 example and matched group 50 examples at random, and the treatment to we is organized in treatment, and matched group treats for the Chinese patent medicine xiao'er ganmao granules.The result: treatment group total effective rate is 94%, and the matched group total effective rate is 82%.Two groups relatively, and significant difference (P＜0.01) shows that we's treatment infantile common cold cough curative effect is comparatively desirable.In the clinical observation process, find to have the effect of leukocyte increasing,, show that this product is to the immunity effect that also improves in conjunction with the pharmacology result.
Prescription of the present invention also can comprise 3～6 parts of Flos Loniceraes, 3～6 parts of Radix Scutellariaes, 3～6 parts on Flos Carthami, 6～9 parts of Fructus Forsythiaes, 3～6 parts of flavour of a drug of Radix Glycyrrhizae, above-mentioned flavour of a drug can add separately or wherein any two to the three flavor medicines of whole adding as required, and make preparation by extraction process of the present invention.
The specific embodiment
The invention will be further described below by implementing, and its purpose only is to understand better content of the present invention and unrestricted protection scope of the present invention:
Embodiment 1
Take by weighing Rhizoma Seu Herba Bergeniae 500g, Santalum album 650g, Concretio Silicea Bambusae 670g, Lagotis brachystachya Maxim. 650g, Tangut aconite 670g, high mountain Radix Cochleariae officinalis dish 500g, Flos Lonicerae 500g, Radix Scutellariae 500g, Fructus Forsythiae 900g decocts with water 2 times, each 2 hours, collects volatile oil; collecting decoction filters, and filtrate concentrating makes extractum (proportion 1.05～1.15); an amount of and the artificial Calculus Bovis 50g with sucrose; wet granulation, airpillow-dry, granulate; add above-mentioned volatile oil; mixing is made 10000g, promptly gets granule of the present invention.(a 0.5-2 bag, 3 times on the one)
Embodiment 2
Take by weighing Rhizoma Seu Herba Bergeniae 600g, Santalum album 600g, Concretio Silicea Bambusae 600g, Lagotis brachystachya Maxim. 600g, Tangut aconite 600g, high mountain Radix Cochleariae officinalis dish 600g, Flos Lonicerae 400g, Flos Carthami 500g, Radix Scutellariae 400g decocts with water 2 times, each 2 hours, collects volatile oil; collecting decoction filters, and filtrate concentrating makes extractum (proportion 1.25～1.35); add an amount of and artificial Calculus Bovis 50g of starch; granulate drying, granulate; add above-mentioned volatile oil; mixing is made 6700, promptly gets capsule of the present invention.(a 1-4 grain, 3 times on the one)
Embodiment 3
Take by weighing Rhizoma Seu Herba Bergeniae 500g, Santalum album 700g, Concretio Silicea Bambusae 600g, Lagotis brachystachya Maxim. 700g, Tangut aconite 600g, high mountain Radix Cochleariae officinalis dish 400g, Flos Lonicerae 500g, Radix Glycyrrhizae 500g, Radix Scutellariae 500g decocts with water 2 times, each 3 hours, collects volatile oil; collecting decoction filters, and filtrate concentrating makes extractum (proportion 1.25～1.35); add an amount of and artificial Calculus Bovis 50g of starch; granulate drying, granulate; add above-mentioned volatile oil; mixing is made 6700, promptly gets tablet of the present invention.(a 1-4 sheet, 3 times on the one)
Embodiment 4
Take by weighing Rhizoma Seu Herba Bergeniae 500g, Santalum album 600g, Concretio Silicea Bambusae 700g, Lagotis brachystachya Maxim. 700g, Tangut aconite 600g, high mountain Radix Cochleariae officinalis dish 400g, Flos Lonicerae 500g, Radix Glycyrrhizae 500g decoct with water 2 times, each 3 hours, collect volatile oil; collecting decoction filters, and filtrate concentrating makes clear paste (proportion 1.05～1.08); spray drying adds an amount of and artificial Calculus Bovis 50g of starch, granulates; dry; granulate adds above-mentioned volatile oil, mixing; make 13300 balls, promptly get pill of the present invention.(a 2-8 ball, 3 times on the one)
The ethnic drug of liver heat removing function of gallbladder promoting is few clinically at present, liver heat removing gallbladder of the present invention, dampness removing heat.Be used for hepatitis, the treatment of cholecystitis, technology is simple, and good effect has certain value of exploiting and utilizing.
Claims (3)
1. pharmaceutical preparation for the treatment of infantile common cold is characterized in that he is by comprising that the following dosage proportion raw material makes: 3～6 parts of Rhizoma Seu Herba Bergeniaes, 6～9 parts of Santalum albums, 6～9 parts of Concretio Silicea Bambusaes, 6～9 parts of Lagotis brachystachya Maxim.s, 6～9 parts of Tangut aconite, 3～6 parts of high mountain Radix Cochleariae officinalis dishes, 0.3～0.6 part of artificial Calculus Bovis.
2. the pharmaceutical preparation of a kind of infantile common cold according to claim 1, it is characterized in that also can comprising in the described raw material 3～6 parts of Flos Loniceraes, 3～6 parts of Radix Scutellariaes, 3～6 parts on Flos Carthami, 6～9 parts of Fructus Forsythiaes, 3～6 parts of flavour of a drug of Radix Glycyrrhizae, above-mentioned flavour of a drug can add separately or wherein any two to the three flavor medicines of whole adding as required.
3. according to the preparation method of the pharmaceutical preparation of claim 1,2 described treatment infantile common colds; it is characterized in that preparation technology carries out as follows: get above except that the artificial Calculus Bovis medical material decoct with water secondary; collect volatile oil; collecting decoction; filter, concentrate, make granule with proper auxiliary materials such as sucrose, dextrin, starch; add the volatile oil of artificial Calculus Bovis and collection, make oral formulations commonly used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010101307235A CN102198230A (en) | 2010-03-24 | 2010-03-24 | Medicinal preparation for treating infantile repeated cold and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101307235A CN102198230A (en) | 2010-03-24 | 2010-03-24 | Medicinal preparation for treating infantile repeated cold and preparation method thereof |
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| CN102198230A true CN102198230A (en) | 2011-09-28 |
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| CN2010101307235A Pending CN102198230A (en) | 2010-03-24 | 2010-03-24 | Medicinal preparation for treating infantile repeated cold and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526536A (en) * | 2012-03-14 | 2012-07-04 | 山东阿如拉药物研究开发有限公司 | An'erning medicinal composition buccal tablet and preparation method and application thereof |
| CN102861142A (en) * | 2012-09-07 | 2013-01-09 | 济南星懿医药技术有限公司 | Pharmaceutical for treating pneumonia, as well as preparation method and quality control method of pharmaceutical formulation |
| CN102885993A (en) * | 2012-09-29 | 2013-01-23 | 西藏奇正藏药股份有限公司 | Application of Tibetan medicament composition in preparation of medicament for treating convulsion |
| CN107050090A (en) * | 2017-06-26 | 2017-08-18 | 北京健旭康技术有限公司 | The effect of beneficial liver and its application of high mountain horseradish dish |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297765A (en) * | 1999-11-26 | 2001-06-06 | 江达县措如寺寺管会 | Tibetans medicine for treating cardiac and cerebral vascular disease and white pulse disease |
| CN101269198A (en) * | 2008-02-29 | 2008-09-24 | 西藏嘉黎县藏医院 | Pure Chinese medicine preparation for preventing and treating enteron disease and improving self phylactic power, and preparation method thereof |
-
2010
- 2010-03-24 CN CN2010101307235A patent/CN102198230A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297765A (en) * | 1999-11-26 | 2001-06-06 | 江达县措如寺寺管会 | Tibetans medicine for treating cardiac and cerebral vascular disease and white pulse disease |
| CN101269198A (en) * | 2008-02-29 | 2008-09-24 | 西藏嘉黎县藏医院 | Pure Chinese medicine preparation for preventing and treating enteron disease and improving self phylactic power, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赫淑倩等: "安儿宁颗粒治疗小儿外感发热180例疗效观察", 《中国医药导报》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526536A (en) * | 2012-03-14 | 2012-07-04 | 山东阿如拉药物研究开发有限公司 | An'erning medicinal composition buccal tablet and preparation method and application thereof |
| CN102526536B (en) * | 2012-03-14 | 2013-07-24 | 山东阿如拉药物研究开发有限公司 | An'erning medicinal composition buccal tablet and preparation method and application thereof |
| CN102861142A (en) * | 2012-09-07 | 2013-01-09 | 济南星懿医药技术有限公司 | Pharmaceutical for treating pneumonia, as well as preparation method and quality control method of pharmaceutical formulation |
| CN102885993A (en) * | 2012-09-29 | 2013-01-23 | 西藏奇正藏药股份有限公司 | Application of Tibetan medicament composition in preparation of medicament for treating convulsion |
| CN102885993B (en) * | 2012-09-29 | 2014-04-23 | 西藏奇正藏药股份有限公司 | Application of Tibetan medicament composition in preparation of medicament for treating convulsion |
| CN107050090A (en) * | 2017-06-26 | 2017-08-18 | 北京健旭康技术有限公司 | The effect of beneficial liver and its application of high mountain horseradish dish |
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Application publication date: 20110928 |