CN1679756A - Delayed-releasing preparation for treating osteoporosis - Google Patents
Delayed-releasing preparation for treating osteoporosis Download PDFInfo
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- CN1679756A CN1679756A CN 200510020133 CN200510020133A CN1679756A CN 1679756 A CN1679756 A CN 1679756A CN 200510020133 CN200510020133 CN 200510020133 CN 200510020133 A CN200510020133 A CN 200510020133A CN 1679756 A CN1679756 A CN 1679756A
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- ethyl cellulose
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Abstract
A slow-releasing Chinese medicine for treating osteoporosis, bone fracture, ostalgia and osteoarthritis is prepared from epimedium, dipsacus root and auxiliary chosen from stearic acid, microcrystalline cellulose, and ethyl cellulose through proportionally dispensing.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation, relate in particular to a kind of slow releasing preparation for the treatment of osteoporosis.
Background technology: the medicine that is used for the treatment of osteoporosis in the prior art has two kinds in Western medicine and Chinese medicine.Western medicine is mainly calcium preparation and estrogen class medicine, therefore, should not take for a long time.Chinese medicine is mainly spleen invigorating stomach alive, nourishing the liver and kidney, and the warming YANG nourishing YIN, the compound Chinese medicinal preparation of promoting flow of QI and blood, dose is big.Because the course of disease of this disease is longer, be generally more than one month a course of treatment of ordinary preparation, and need repeatedly take every day, causes the patient that the compliance of taking medicine is descended easily, and Chang Yin misses and do not reach therapeutic effect, and take for a long time toxic and side effects is increased.
Summary of the invention: in order to overcome the deficiencies in the prior art, the present invention aims to provide a kind of slow releasing function that has, and is used for the treatment of the oral preparation of Chinese traditional medicinal of diseases such as osteoporosis, fracture, osteodynia, osteoarthritis.
Technical scheme of the present invention is made by the raw material of following consumption, principal agent: the final mixed extract of Herba Epimedii 2500～5000 grams, Radix Dipsaci 500～1000 grams; Adjuvant: stearic acid, microcrystalline Cellulose, ethyl cellulose; The final mixed extract of principal agent and adjuvant are by weight configuration.
The ratio of the final mixed extract of principal agent and stearic acid, microcrystalline Cellulose, ethyl cellulose is 1: 0.6～1.5: 0.4～1: 0.1～0.5; The weight ratio of micropill and microcrystalline Cellulose, ethyl cellulose is 1: 0.2～0.5: 0.4～1, and described micropill is made in 1: 0.4～1: 0.01～0.04 ratio by final mixed extract and stearic acid, the ethyl cellulose of principal agent.
Above-mentioned Herba Epimedii can be coarse wool Herba Epimedii Epimedim acumintum Franch, arrow leaf Herba Epimedii E.Sagittatum (Sieb.et Zuce.) Maxim, Herba Epimedii E.japenica or Qian ridge barrenwort E.Leptorrhizum Stearn, belongs to little thumb section plant; Radix Dipsaci is the dry root of plant Dipsacusasperoldes C.Y.Cheng et T.M.Ai, belongs to Dipsacaceae.
Compared with the prior art, the present invention can keep certain blood drug level in a long time, administration number of times is few, therefore avoided ordinary preparation to produce " peak valley " phenomenon of blood drug level owing to frequent drug administration, stable curative effect, dose are little, safe, are particularly suitable for the patient that need take medicine for a long time.
The specific embodiment: the invention will be further described below in conjunction with specific embodiment:
Embodiment 1, gets principal agent: Herba Epimedii 2500 grams, Radix Dipsaci 500 grams; The final mixed extract of principal agent per 1 is restrained and adjuvant: stearic acid, microcrystalline Cellulose, ethyl cellulose were in 1: 0.6: 0.4: 0.1 ratio is granulated, and incapsulates or suppresses in flakes.
Embodiment 2, get principal agent: Herba Epimedii 3500 grams, Radix Dipsaci 700 grams; The final mixed extract of principal agent per 1 is restrained and adjuvant: stearic acid, microcrystalline Cellulose, ethyl cellulose were in 1: 0.9: 0.6: 0.3 ratio is granulated, and incapsulates or suppresses in flakes.
Embodiment 3, get principal agent: Herba Epimedii 5000 grams, Radix Dipsaci 1000 grams; The final mixed extract of principal agent per 1 is restrained and adjuvant: stearic acid, microcrystalline Cellulose, ethyl cellulose were in 1: 1.2: 0.8: 0.5 ratio is granulated, and incapsulates or suppresses in flakes.
Embodiment 4, get principal agent: Herba Epimedii 2500 grams, Radix Dipsaci 500 grams; The final mixed extract of principal agent per 1 is restrained and adjuvant: stearic acid, ethyl cellulose are made micropill in 1: 0.4: 0.01 ratio, and every gram micropill and microcrystalline Cellulose, ethyl cellulose are made matrix tablet in 1: 0.2: 0.4 ratio.
Embodiment 5, get principal agent: Herba Epimedii 3500 grams, Radix Dipsaci 700 grams; The final mixed extract of principal agent per 1 is restrained and adjuvant: stearic acid, ethyl cellulose are made micropill in 1: 0.7: 0.02 ratio, and every gram micropill and microcrystalline Cellulose, ethyl cellulose are made matrix tablet in 1: 0.4: 0.7 ratio.
Embodiment 6, get principal agent: Herba Epimedii 5000 grams, Radix Dipsaci 1000 grams; The final mixed extract of principal agent per 1 is restrained and adjuvant: stearic acid, ethyl cellulose are made micropill in 1: 1: 0.04 ratio, and every gram micropill and microcrystalline Cellulose, ethyl cellulose are made matrix tablet in 1: 0.5: 1 ratio.
Preparation method of the present invention is as follows:
One. get Herba Epimedii 2500～5000 grams, Radix Dipsaci 500～1000 gram blending waters decoctions 3 times, add 10～12 times of amounts of water at every turn, decocted 1.5 hours at every turn; Filter, collecting decoction, being concentrated into relative density is 1.08 (60 ℃); Add ethanol, make ethanol content reach 65%, left standstill 48 hours, filter, filtrate recycling ethanol is condensed into the fluid extract that relative density is 1.16～1.18 (room temperatures).Or be 50%～90% the direct reflux, extract, of ethanol 5 times with concentration, add 6～8 times of amounts of ethanol at every turn, extracted 1 hour at every turn; Filter, merging filtrate reclaims ethanol, is concentrated into the fluid extract that relative density is 1.16～1.18 (room temperatures).
Two. above-mentioned fluid extract with water saturated n-butanol extraction 5 times, is merged butanol extraction liquid, washing, reclaim under reduced pressure n-butyl alcohol; N-butanol extracting liquid is behind absorption with macroporous adsorbent resin, with 30%～80% ethanol or acetone eluting; Eluent reclaims spray-dried or vacuum drying behind the solvent, the final mixed extract of principal agent, that is: effective part group extract powder.
Three. the above-mentioned effective part group extract powder that obtains and stearic acid, microcrystalline Cellulose, ethyl cellulose are granulated in 1: 0.6～1.5: 0.4～1: 0.1～0.5 ratio, incapsulate and make slow releasing capsule; Perhaps suppress the slow releasing tablet that gets in blocks.
Four. the above-mentioned effective part group extract powder that obtains and stearic acid, ethyl cellulose are made micropill in 1: 0.4～1: 0.01～0.04 ratio, again micropill and microcrystalline Cellulose, ethyl cellulose are made matrix tablet in 1: 0.2～0.5: 0.4～1 ratio.
Claims (3)
1. slow releasing preparation for the treatment of osteoporosis, it is characterized in that: the raw material by following consumption is made, principal agent: the final mixed extract of Herba Epimedii 2500～5000 grams, Radix Dipsaci 500～1000 grams; Adjuvant: stearic acid, microcrystalline Cellulose, ethyl cellulose; The final mixed extract of principal agent and adjuvant are by weight configuration.
2. the slow releasing preparation of treatment osteoporosis according to claim 1 is characterized in that: the ratio of the final mixed extract of principal agent and stearic acid, microcrystalline Cellulose, ethyl cellulose is 1: 0.6～1.5: 0.4～1: 0.1～0.5.
3. the slow releasing preparation of treatment osteoporosis according to claim 1, it is characterized in that: the weight ratio of micropill and microcrystalline Cellulose, ethyl cellulose is 1: 0.2～0.5: 0.4～1, and described micropill is made in 1: 0.4～1: 0.01～0.04 ratio by final mixed extract and stearic acid, the ethyl cellulose of principal agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100201336A CN1319546C (en) | 2005-01-06 | 2005-01-06 | Delayed-releasing preparation for treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100201336A CN1319546C (en) | 2005-01-06 | 2005-01-06 | Delayed-releasing preparation for treating osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1679756A true CN1679756A (en) | 2005-10-12 |
| CN1319546C CN1319546C (en) | 2007-06-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100201336A Active CN1319546C (en) | 2005-01-06 | 2005-01-06 | Delayed-releasing preparation for treating osteoporosis |
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| CN (1) | CN1319546C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666393A (en) * | 2014-07-09 | 2015-06-03 | 普正药业股份有限公司 | Anti-osteoporosis eucommia ulmoides sustained-release tablet and preparation method thereof |
| CN114796325A (en) * | 2022-05-25 | 2022-07-29 | 暨南大学附属第一医院（广州华侨医院） | Traditional Chinese medicine composition for treating knee osteoarthritis and preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1498629A (en) * | 2002-11-11 | 2004-05-26 | 刘香斌 | Chinese traditional medicine for treating osteoporosis and its prepn. method |
| CN1207041C (en) * | 2003-04-24 | 2005-06-22 | 谢亚苏 | Medicine for treating osteoporosis and its preparing process |
-
2005
- 2005-01-06 CN CNB2005100201336A patent/CN1319546C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666393A (en) * | 2014-07-09 | 2015-06-03 | 普正药业股份有限公司 | Anti-osteoporosis eucommia ulmoides sustained-release tablet and preparation method thereof |
| CN114796325A (en) * | 2022-05-25 | 2022-07-29 | 暨南大学附属第一医院（广州华侨医院） | Traditional Chinese medicine composition for treating knee osteoarthritis and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN1319546C (en) | 2007-06-06 |
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