CN1413711A - Preparation technology of - Google Patents
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- CN1413711A CN1413711A CN 02134148 CN02134148A CN1413711A CN 1413711 A CN1413711 A CN 1413711A CN 02134148 CN02134148 CN 02134148 CN 02134148 A CN02134148 A CN 02134148A CN 1413711 A CN1413711 A CN 1413711A
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- fine powder
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- poria
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Abstract
A process for preparing the Chinese medicine "Liuweidihuang capsule" includes such steps as extracting, concentrating, extracting by macroreticular resin, concentrating and refining. Its advantage is improved curative effect.
Description
Technical field: the present invention is a kind of production technology of LIUWEIDIHUANG JIAONANG, belongs to the production of medicine
Technical field.
Technical background: the main effect of LIUWEIDIHUANG JIAONANG is enriching yin and nourishing kidney, is used for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, symptom such as quench one's thirst; Traditional production method adopts more common technology with all medical material mix homogeneously, and its efficacy of a drug deficiency needs the patient to take 16 day and just can reach therapeutic effect; There is " production method of Chinese medicine Liuwei Dihuang preparation " to apply for national inventing patent in the Chinese patent application, this technology has solved the purified inadequately problem of active ingredient of prior art Chinese crude drug, the quantity of obeying 8 the product needs of patients day of original technology production is reduced to the level that only needs 4 of day clothes, just can reaches identical therapeutic effect; But according to existing technology still the active ingredient of this medicine further can be concentrated, refine, and obtained success through test repeatedly.
Summary of the invention: the objective of the invention is to: the production technology that a kind of LIUWEIDIHUANG JIAONANG is provided, this method is according to the different characteristics of these medical materials self, choose corresponding fabrication and processing method and utilize Amberlyst process to extract active ingredient in the medical material, make medicine refine more like this, drug effect is more remarkable, reduces user's the quantity of taking, and only need 2 every day, make the patient be easy to more accept, alleviate patients ' psychological, physiological fear; The present invention is achieved in that the medical material of use is: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, and method is:
A, the Poria powder of 30%-40% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, pass through macroporous adsorptive resins, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products; More specific technology is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni adds the alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, also carry out crystallization according to conventional way, filter then, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, ethanol elution with 70% reclaims ethanol, is concentrated into the thick paste shape, add the Poria thick paste that has obtained, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, at Cortex Moutan extract fine powder that adds acquisition and an amount of conventional adjuvant, in incapsulating behind the mix homogeneously, get 1000 granule products.More specifically technology is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni decocts with water three times, each 1 hour, filter, medicinal residues add 90% alcohol reflux secondary of 5 times of amounts, each 1 hour, filter, filtrate recycling ethanol is concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, and make its crystallization, filter, crystallization washes with water, cold drying is ground into fine powder, the aqueous solution after the distillation and Cortex Moutan medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate by macroporous adsorptive resins, is collected trickle from resin column, suitably concentrate the back and add isopyknic 95% ethanol, stir, left standstill 24 hours, filter, the taking precipitate cold drying, pulverize, with 70% ethanol elution, eluent is incorporated Fructus Corni backflow recovery ethanol into adsorbent resin, be concentrated into the thick paste shape, add the Poria thick paste and the fine powder that have obtained, mix homogeneously, drying, be ground into powder again, add Cortex Moutan extract fine powder and resin column effluent extract, in incapsulating behind the mix homogeneously, get 1000 granule products.Compared with prior art: simple, the easy row of production method technology provided by the invention, the medicine that obtains further concentrates, refine, drug effect is concentrated more, is given prominence to, the efficacy of a drug is more obvious, take this medicine, only need every day secondary, each 1 to get final product, the medicine that obtains than prior art lacks the multiple amount of taking; Employing will collect, handle by effusive effluent from resin column, though increased certain operation, this method has kept the polysaccharide composition in the medical material fully, has improved the effect of manufactured goods.
Embodiments of the invention 1: the regulation according to state-promulgated pharmacopoeia is selected medical material for use: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, concrete grammar is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni adds the alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, ethanol elution with 70% reclaims ethanol, is concentrated into the thick paste shape, add the Poria thick paste that has obtained, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, at Cortex Moutan extract fine powder that adds acquisition and an amount of conventional adjuvant, in incapsulating behind the mix homogeneously, get 1000 granule products.
Embodiments of the invention 2: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, method is:
A, the Poria powder of 40% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, pass through macroporous adsorptive resins, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products.
Embodiments of the invention 3: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, method is:
A, the Poria powder of 30% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, cross resin column, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products.
Embodiments of the invention 4: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni decocts with water three times, each 1 hour, filter, medicinal residues add 90% alcohol reflux secondary of 5 times of amounts, each 1 hour, filter, filtrate recycling ethanol is concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, and make its crystallization, filter, crystallization washes with water, cold drying is ground into fine powder, the aqueous solution after the distillation and Cortex Moutan medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate by macroporous adsorptive resins, is collected trickle from resin column, suitably concentrate the back and add isopyknic 95% ethanol, stir, left standstill 24 hours, filter, the taking precipitate cold drying, pulverize, with 70% ethanol elution, eluent is incorporated Fructus Corni backflow recovery ethanol into adsorbent resin, be concentrated into the thick paste shape, add the Poria thick paste and the fine powder that have obtained, mix homogeneously, drying, be ground into powder again, add Cortex Moutan extract fine powder and resin column effluent extract, in incapsulating behind the mix homogeneously, get 1000 granule products.
Claims (3)
1, a kind of production technology of LIUWEIDIHUANG JIAONANG, wherein Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 restrain, Poria 528 restrains, Rhizoma Alismatis 538 grams, it is characterized in that:
A, the Poria powder of 30%-40% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, pass through macroporous adsorptive resins, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products.
2, production technology according to the described this LIUWEIDIHUANG JIAONANG of claim 1, it is characterized in that: technology is particularly: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni adds the alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, ethanol elution with 70% reclaims ethanol, is concentrated into the thick paste shape, add the Poria thick paste that has obtained, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, at Cortex Moutan extract fine powder that adds acquisition and an amount of adjuvant, in incapsulating behind the mix homogeneously, get 1000 granule products.
3, according to claim 1, the production technology of 2 described this LIUWEIDIHUANG JIAONANG, it is characterized in that: more specifically technology is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni decocts with water three times, each 1 hour, filter, medicinal residues add 90% alcohol reflux secondary of 5 times of amounts, each 1 hour, filter, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, collection is trickle from resin column, suitably concentrates the back and adds isopyknic 95% ethanol, stirs, left standstill 24 hours, filter, the taking precipitate cold drying is pulverized, with adsorbent resin with 70% ethanol elution, eluent is incorporated the Fructus Corni backflow into and is reclaimed ethanol, is concentrated into the thick paste shape, adds the Poria thick paste and the fine powder that have obtained, mix homogeneously, drying is ground into powder again, adds Cortex Moutan extract fine powder and resin column effluent extract, in incapsulating behind the mix homogeneously, get 1000 granule products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021341486A CN1175873C (en) | 2002-11-19 | 2002-11-19 | Preparation technology of |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021341486A CN1175873C (en) | 2002-11-19 | 2002-11-19 | Preparation technology of |
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| Publication Number | Publication Date |
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| CN1413711A true CN1413711A (en) | 2003-04-30 |
| CN1175873C CN1175873C (en) | 2004-11-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021341486A Expired - Fee Related CN1175873C (en) | 2002-11-19 | 2002-11-19 | Preparation technology of |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN104096040A (en) * | 2013-04-14 | 2014-10-15 | 江西普正制药有限公司 | Preparation method of six-ingredient rehmannia capsules |
| CN105609639A (en) * | 2015-12-23 | 2016-05-25 | 海安常州大学高新技术研发中心 | Low-temperature preparation method for organic/inorganic hybrid perovskite solar cell |
| CN106214911A (en) * | 2016-08-22 | 2016-12-14 | 湖南康尔佳制药股份有限公司 | A kind of medicine of enriching yin and nourishing kidney and preparation method thereof |
| CN115137786A (en) * | 2022-07-29 | 2022-10-04 | 吉林省民泰制药股份有限公司 | A capsule containing six ingredients with rehmanniae radix and its preparation method |
-
2002
- 2002-11-19 CN CNB021341486A patent/CN1175873C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104096040A (en) * | 2013-04-14 | 2014-10-15 | 江西普正制药有限公司 | Preparation method of six-ingredient rehmannia capsules |
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN105609639A (en) * | 2015-12-23 | 2016-05-25 | 海安常州大学高新技术研发中心 | Low-temperature preparation method for organic/inorganic hybrid perovskite solar cell |
| CN106214911A (en) * | 2016-08-22 | 2016-12-14 | 湖南康尔佳制药股份有限公司 | A kind of medicine of enriching yin and nourishing kidney and preparation method thereof |
| CN115137786A (en) * | 2022-07-29 | 2022-10-04 | 吉林省民泰制药股份有限公司 | A capsule containing six ingredients with rehmanniae radix and its preparation method |
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| Publication number | Publication date |
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| CN1175873C (en) | 2004-11-17 |
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Owner name: MA CUIPING Free format text: FORMER OWNER: GAO YANG Effective date: 20041029 |
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Effective date of registration: 20041029 Address after: 550004 No. 467 North Road, Guiyang, Guizhou Patentee after: Guizhou Kangna Shengfang Pharmaceutical Co.,Ltd. Address before: 550004, Guizhou province Guiyang City North Road 467, Chen Ping turn Patentee before: Gao Yang |
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