CN100444835C - Tendon-relaxing blood circulation-activating capsule and preparation process thereof - Google Patents
Tendon-relaxing blood circulation-activating capsule and preparation process thereof Download PDFInfo
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- CN100444835C CN100444835C CNB2006100317341A CN200610031734A CN100444835C CN 100444835 C CN100444835 C CN 100444835C CN B2006100317341 A CNB2006100317341 A CN B2006100317341A CN 200610031734 A CN200610031734 A CN 200610031734A CN 100444835 C CN100444835 C CN 100444835C
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- 239000002775 capsule Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000008280 blood Substances 0.000 title claims description 16
- 210000004369 blood Anatomy 0.000 title claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 238000005516 engineering process Methods 0.000 claims abstract description 20
- 239000008187 granular material Substances 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 229920002472 Starch Polymers 0.000 claims abstract description 8
- 239000008107 starch Substances 0.000 claims abstract description 8
- 235000019698 starch Nutrition 0.000 claims abstract description 8
- 239000000047 product Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 239000006228 supernatant Substances 0.000 claims abstract description 4
- 241000628997 Flos Species 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 7
- 239000012567 medical material Substances 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 235000013312 flour Nutrition 0.000 claims 4
- 230000017531 blood circulation Effects 0.000 abstract description 8
- 239000003814 drug Substances 0.000 abstract description 8
- 235000019658 bitter taste Nutrition 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 230000002040 relaxant effect Effects 0.000 abstract description 2
- 210000002435 tendon Anatomy 0.000 abstract description 2
- 235000011202 Angiopteris lygodiifolia Nutrition 0.000 abstract 1
- 235000002470 Asclepias syriaca Nutrition 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000723185 Cyathea Species 0.000 abstract 1
- 235000018109 Cyperus longus Nutrition 0.000 abstract 1
- 244000150195 Cyperus longus Species 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 235000014066 European mistletoe Nutrition 0.000 abstract 1
- 240000005779 Jasminum multiflorum Species 0.000 abstract 1
- 241000195954 Lycopodium clavatum Species 0.000 abstract 1
- 241000893851 Periploca graeca Species 0.000 abstract 1
- 244000152640 Rhipsalis cassutha Species 0.000 abstract 1
- 235000012300 Rhipsalis cassutha Nutrition 0.000 abstract 1
- 235000005010 Scirpus paludosus Nutrition 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000009966 trimming Methods 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 239000006071 cream Substances 0.000 description 5
- 230000002349 favourable effect Effects 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000009776 industrial production Methods 0.000 description 3
- 238000000540 analysis of variance Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004134 energy conservation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000005242 forging Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011981 development test Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a capsule for relaxing tendons and activating blood circulation and a preparation technology of the capsule. Safflower, nutgrass galingale rhizome, east asian tree fern, Chinese silkvine bark are pulverized into fine powder and are sieved; native copper is added with 8 times amount of water to be decocted for two hours; then, Chinese starjasmine, common clubmoss herb, herba lycopi, coloed mistletoe herb and suberect spatholobus stem are decocted by twice; at the first time, 12 times amount of water is added to be decocted for three hours; at the second time, 10 times amount of water is added to be decocted for two hours; the decocted liquid is merged, filtered and statically placed; supernatant fluid is decompressed and concentrated into thick paste; 256g of powder and 28 to 30g of starch are added to be manufactured into 1000 granules through uniform mixing, granulating, drying and granule trimming. The product prepared with preparation technology of the present invention has stable and reliable product quality and moisture prevention and good economic benefits, masks the bitterness of original drugs and shortens disintegration time limited; the product is suitable for patients who do not eat sugar and provides good medication selection for both doctors and patients. The preparation technology of the present invention has the advantages of energy saving, reduction of production period and cost, integrity, perfection and large-scale industrialization.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine tendon-relaxing blood circulation-activating capsule and preparation technology thereof.
Background technology
In the existing Chinese medicine preparation, tablet for relieving rigidity of muscles and promoting blood circulation has relaxing muscles and tendons and activating QI and blood in the collateral, the effect of promoting blood circulation to remove blood stasis.Be used for the treatment of bones and muscles pain, limbs are arrested twin, aching pain in waist and back, slight illness such as traumatic injury.But existing tablet for relieving rigidity of muscles and promoting blood circulation is plain sheet, and disintegration is long, and the effective ingredient dissolution rate in the tablet is slow, bitter in the mouth.And contain happy sugar in the tablet for relieving rigidity of muscles and promoting blood circulation, be unfavorable for that then some sugar avoiding patients take.Original in addition tablet for relieving rigidity of muscles and promoting blood circulation preparation technology is perfect inadequately, and some influence the not explanation of factors of effective component extracting effect, as amount of water what, concentrates, exsiccant condition etc.If will make tendon-relaxing blood circulation-activating capsule into, then should adopt which kind of adjuvant just suitable, how many consumptions is, how could more favourable sugar avoiding patients take; The technology of what kind of production is only the optimal preparation technology of tendon-relaxing blood circulation-activating capsule, how to reduce cost as much as possible, improves the quality, and helps the problem that large-scale industrial production all is the required solutions of the present inventor.
Summary of the invention
Purpose of the present invention aims to provide a kind of stripping that can favourable effective ingredient, more stable quality is reliable, has protection against the tide, and can cover former medicine bitterness, shortens disintegration, and can produce the tendon-relaxing blood circulation-activating capsule of better economic benefit.
Another object of the present invention be intended to a kind of can be energy-conservation well, shorten the production cycle, reduce production costs, technology is more complete, and is perfect, the preparation technology of the tendon-relaxing blood circulation-activating capsule of favourable large-scale industrial production.
The objective of the invention is to realize by following manner:
Capsule of the present invention is formed by following feedstock production, Flos Carthami 21g, Rhizoma Cyperi (system) 78.6g, Rhizoma Cibotii (system) 104.8g, Cortex Periplocae 52.4g, Caulis Trachelospermi 78.6g, Herba Lycopodii 78.6g, herba lycopi 78.6g, Herba Visci 104.8g, Caulis Spatholobi 78.6g, Pyritum (forging) 13.1g; Add supplementary product starch 28-30g.
Preparation technology of the present invention is: above ten flavors, earlier Flos Carthami, Rhizoma Cyperi, Rhizoma Cibotii, Cortex Periplocae are ground into fine powder, and sieve; Pyritum adds 8 times of water gagings and decocted 2 hours, adds Caulis Trachelospermi, Herba Lycopodii, herba lycopi, Herba Visci, Caulis Spatholobi decoction secondary then, adds 12 times of water gagings 3 hours for the first time, adds 10 times of water gagings 2 hours for the second time, collecting decoction filters, and leaves standstill, supernatant adopts the concentrating under reduced pressure method, and temperature is controlled at 60-70 ℃, and vacuum is that 0.07-0.08Mpa is condensed into thick paste, add above-mentioned powder 256g, add starch 28-30g, mixing, granulate drying, granulate, encapsulated, make 1000, promptly.
Described granulation is to granulate through 20 mesh sieves.
Exsiccant temperature is controlled at 70 ℃, and temperature rises gradually when dry, so that intragranular water evaporates.The granule water content is controlled at less than 2%.
Described granulate is through using 20 mesh sieve granulate.
Production technology of the present invention is that the present inventor fully studies and test of many times obtains, and below is the inventor's development test situation.
The investigation of water extraction condition
Get Pyritum 2.5g (adding 8 times of water gagings earlier decocted 2 hours), Caulis Trachelospermi 15g, Herba Lycopodii 15g, herba lycopi 15g, Herba Visci 20g, Caulis Spatholobi 15g (82.5g altogether), doubly amount, soak time, extraction time are the examination factor to add water, each factor is selected three different levels, and the factor level table sees Table 1.Promoting yield of extract with water serves as to investigate index, determines optimised process, presses L
9(3
4) table does orthogonal test.
Table 1 factor level table
(1) water is promoted extractum preparation and yield determination method
Get Pyritum 2.5g (adding 8 times of water gagings earlier decocted 2 hours), Caulis Trachelospermi 15g, Herba Lycopodii 15g, herba lycopi 15g, Herba Visci 20g, Caulis Spatholobi 15g (82.5g altogether) in the prescription ratio, decoct with water by Orthogonal Experiment and Design and (to weigh earlier before each the extraction, boil to preceding 10 minutes of stipulated time and weigh and add water again to former weight, boiled again 10 minutes), filter, filtrate is concentrated into small size, move in the evaporating dish of known weight, put evaporate to dryness in the water-bath, again in 105 ℃ of dryings 3 hours, put in the exsiccator and cooled off 0.5 hour, precision is weighed, and is calculated as follows dried cream yield.
(2) water is proposed orthogonal test scheme, result and variance analysis
Table 2 water is carried orthogonal test scheme and table as a result
Table 3 water is carried the dried cream yield of quadrature analysis of variance table
Wherein " * " looks into F-distribution critical table: F for significant difference is arranged
0.05(2,2)=and 19.00. promotes cream yield The results of analysis of variance as can be known from table 4 water: the C factor has significant difference (P＜0.05), A, B factor there was no significant difference (P＞0.05), that is: there is appreciable impact extraction time to dried cream yield, and amount of water, soak time do not make significant difference.By range analysis as can be known, the influence to dried cream yield is in proper order: C＞A＞B, A in the A factor
3＞A
2＞A
1, select best level A
3, B in the B factor
1＞B
2＞B
3, select best level B
1, C in the C factor
3＞C
2＞C
1, select best level C
3, the intuitive analysis result shows that optimised process consists of A
3B
1C
3The material of promptly getting it filled decocts with water secondary, adds 12 times of water gagings 3 hours for the first time, adds 10 times of water gagings 2 hours for the second time.
The condition of concentrating
Concentrate with two kinds of methods of concentrating under reduced pressure through normal pressure and to compare: adopt the concentrating under reduced pressure method, temperature is controlled at 60-70 ℃, and vacuum is 0.07-0.08Mpa, can shorten concentration time, reduces the ointment loss, preserves the effective ingredient in the medicinal liquid.
Study on Forming
The selection of adjuvant
Replace adjuvant with medical material fine powders such as Flos Carthamis in the moulding process, whole compositions of medicine both can have been preserved, escapable cost again, so in the moulding process of capsule still with medical material fine powder instead of part adjuvants such as Flos Carthamis, the inventor considers the demand of some sugar avoiding patient, do not re-use maltose, only add starch and supply weight.
Get medical material fine powder such as thick paste of the present invention and Flos Carthami and starch and mix, 20 mesh sieves are granulated.
Wet grain is dry: after wet granular of the present invention is made, and should be in time dry.Exsiccant temperature is controlled at 70 ℃, and temperature rises gradually when dry, so that intragranular water evaporates.The granule water content is controlled at less than 2%.
Granulate: during particle drying, in bulk is arranged slightly, through using 20 mesh sieve granulate, even particle size is convenient to fill.
Tablet for relieving rigidity of muscles and promoting blood circulation and tendon-relaxing blood circulation-activating capsule comparison sheet
The above results shows: the former tablet for relieving rigidity of muscles and promoting blood circulation of the mass ratio of tendon-relaxing blood circulation-activating capsule of the present invention increases.
In sum, the stripping that product of the present invention can favourable effective ingredient, more stable quality is reliable, have protection against the tide, and can cover former medicine bitterness, shorten disintegration, help sugar avoiding patient and take, select, can produce better economic benefit for doctor and patient provides medication better.Preparation technology of the present invention can be energy-conservation well, shorten the production cycle, reduces production costs, and technology is more complete, and is perfect, favourable large-scale industrial production.
The specific embodiment
Flos Carthami 21g, Rhizoma Cyperi (system) 78.6g, Rhizoma Cibotii (system) 104.8g, Cortex Periplocae 52.4g, Caulis Trachelospermi 78.6g, Herba Lycopodii 78.6g, herba lycopi 78.6g, Herba Visci 104.8g, Caulis Spatholobi 78.6g, Pyritum (forging) 13.1g;
Preparation technology of the present invention is: above ten flavors, earlier Flos Carthami, Rhizoma Cyperi, Rhizoma Cibotii, Cortex Periplocae are ground into fine powder, and sieve; Pyritum adds 8 times of water gagings and decocted 2 hours, add Caulis Trachelospermi, Herba Lycopodii, herba lycopi, Herba Visci, Caulis Spatholobi decoction secondary then, add for the first time 12 times of water gagings 3 hours, add for the second time 10 times of water gagings 2 hours, collecting decoction filters, and leaves standstill, supernatant adopts the concentrating under reduced pressure method, temperature is controlled at 60-70 ℃, and vacuum is that 0.07-0.08Mpa is condensed into thick paste, adds above-mentioned powder 256g, add starch 29g, mixing is granulated through 20 mesh sieves, and exsiccant temperature is controlled at 70 ℃, temperature rises gradually when dry, so that intragranular water evaporates.The granule water content is controlled at less than 2%.Through using 20 mesh sieve granulate, encapsulated, make 1000, promptly.
Claims (5)
1, tendon-relaxing blood circulation-activating capsule is formed by following feedstock production, Flos Carthami 21g, Rhizoma Cyperi 78.6g, Rhizoma Cibotii 104.8g, Cortex Periplocae 52.4g, Caulis Trachelospermi 78.6g, Herba Lycopodii 78.6g, herba lycopi 78.6g, Herba Visci 104.8g, Caulis Spatholobi 78.6g, Pyritum 13.1g; Add supplementary product starch 28-30g.
2, the preparation technology of the described tendon-relaxing blood circulation-activating capsule of claim 1 is: get Flos Carthami, Rhizoma Cyperi, Rhizoma Cibotii, Cortex Periplocae and be ground into fine powder, the average flour extraction of flos carthami is 96.98%, crosses 80 mesh sieves; The average flour extraction of Rhizoma Cyperi medical material is 97.28%, crosses 80 mesh sieves; The average flour extraction of Rhizoma Cibotii medical material is 97.24%; The average flour extraction of Cortex Periplocae medical material is 96.88%, Pyritum adds 8 times of water gagings and decocted 2 hours, adds Caulis Trachelospermi, Herba Lycopodii, herba lycopi, Herba Visci, Caulis Spatholobi decoction secondary then, adds 12 times of water gagings 3 hours for the first time, add for the second time 10 times of water gagings 2 hours, collecting decoction filters, and leaves standstill, supernatant adopts the concentrating under reduced pressure method, temperature is controlled at 60-70 ℃, and vacuum is that 0.07-0.08Mpa is condensed into thick paste, adds above-mentioned powder 256g, add starch 29g, mixing is granulated drying, granulate, encapsulated, make 1000, promptly.
3, the preparation technology of tendon-relaxing blood circulation-activating capsule according to claim 2, described granulation is to granulate through 20 mesh sieves.
4, the preparation technology of tendon-relaxing blood circulation-activating capsule according to claim 2, exsiccant temperature are controlled at 70 ℃, and the granule water content is controlled at less than 2%.
5, the preparation technology of tendon-relaxing blood circulation-activating capsule according to claim 2, described granulate is through using 20 mesh sieve granulate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100317341A CN100444835C (en) | 2006-05-30 | 2006-05-30 | Tendon-relaxing blood circulation-activating capsule and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100317341A CN100444835C (en) | 2006-05-30 | 2006-05-30 | Tendon-relaxing blood circulation-activating capsule and preparation process thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1883635A CN1883635A (en) | 2006-12-27 |
| CN100444835C true CN100444835C (en) | 2008-12-24 |
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|---|---|---|---|
| CNB2006100317341A Active CN100444835C (en) | 2006-05-30 | 2006-05-30 | Tendon-relaxing blood circulation-activating capsule and preparation process thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198209B (en) * | 2011-05-18 | 2012-12-05 | 杭州华东医药集团康润制药有限公司 | Tendon-relaxing and blood-activating capsules and preparation process thereof |
| CN102652768A (en) * | 2012-04-11 | 2012-09-05 | 南京同仁堂药业有限责任公司 | Medicinal composition for relaxing tendons, activating collaterals, promoting blood circulation and removing blood stasis |
| CN114949096B (en) * | 2022-07-08 | 2024-03-19 | 太极集团四川绵阳制药有限公司 | Preparation method of tablet for relaxing muscles and stimulating blood circulation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895549A (en) * | 2006-06-13 | 2007-01-17 | 孙津舒 | Soothe tendons and activating-blood anodyne plaster |
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2006
- 2006-05-30 CN CNB2006100317341A patent/CN100444835C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895549A (en) * | 2006-06-13 | 2007-01-17 | 孙津舒 | Soothe tendons and activating-blood anodyne plaster |
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