CN114949096B - Preparation method of tablet for relaxing muscles and stimulating blood circulation - Google Patents
Preparation method of tablet for relaxing muscles and stimulating blood circulation Download PDFInfo
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- CN114949096B CN114949096B CN202210799465.2A CN202210799465A CN114949096B CN 114949096 B CN114949096 B CN 114949096B CN 202210799465 A CN202210799465 A CN 202210799465A CN 114949096 B CN114949096 B CN 114949096B
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- tablet
- sucrose
- blood circulation
- relaxing muscles
- maltose
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- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 230000017531 blood circulation Effects 0.000 title claims abstract description 19
- 210000003205 muscle Anatomy 0.000 title claims abstract description 19
- 230000002040 relaxant effect Effects 0.000 title claims abstract description 19
- 230000004936 stimulating effect Effects 0.000 title claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 46
- 229930006000 Sucrose Natural products 0.000 claims abstract description 35
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 35
- 239000005720 sucrose Substances 0.000 claims abstract description 35
- 238000002156 mixing Methods 0.000 claims abstract description 31
- 239000000284 extract Substances 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 229920002261 Corn starch Polymers 0.000 claims abstract description 10
- 239000008120 corn starch Substances 0.000 claims abstract description 10
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 27
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 27
- 238000010438 heat treatment Methods 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 13
- 239000006188 syrup Substances 0.000 claims description 13
- 235000020357 syrup Nutrition 0.000 claims description 13
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 239000007779 soft material Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 244000020518 Carthamus tinctorius Species 0.000 claims description 10
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 10
- 244000150195 Cyperus longus Species 0.000 claims description 10
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 235000021419 vinegar Nutrition 0.000 claims description 8
- 239000000052 vinegar Substances 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
- 235000014066 European mistletoe Nutrition 0.000 claims description 7
- 240000005779 Jasminum multiflorum Species 0.000 claims description 7
- 241000195954 Lycopodium clavatum Species 0.000 claims description 7
- 235000012300 Rhipsalis cassutha Nutrition 0.000 claims description 7
- 241000913745 Spatholobus Species 0.000 claims description 7
- 229910052802 copper Inorganic materials 0.000 claims description 7
- 239000010949 copper Substances 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 230000001737 promoting effect Effects 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 210000002435 tendon Anatomy 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 244000152640 Rhipsalis cassutha Species 0.000 claims 2
- 239000000463 material Substances 0.000 abstract description 18
- 238000000605 extraction Methods 0.000 abstract description 2
- 229960004793 sucrose Drugs 0.000 description 28
- 239000000047 product Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 241000221012 Viscum Species 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 241001148494 Cibotium Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000009775 high-speed stirring Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000025940 Back injury Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 229960004016 sucrose syrup Drugs 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
Classifications
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a preparation method of a tablet for relaxing muscles and stimulating blood circulation, which belongs to the field of medicines, and comprises the steps of mixing fine powder of medicinal materials with sucrose powder and corn starch by a double-power quick-release mixer, and then directly adding extract after extraction and concentration of the medicinal materials for stirring and granulating.
Description
Technical Field
The invention relates to the field of medicines, in particular to a preparation method of a tablet for relaxing muscles and stimulating blood circulation.
Background
Tablet for relaxing muscles and tendons and promoting blood circulation, and is used for relaxing muscles and tendons and activating collaterals, promoting blood circulation and removing blood stasis. Can be used for treating arthralgia and myalgia, limb spasm, soreness of waist and back, and traumatic injury.
The national medicine standard of the national food and medicine administration of the tablet for relaxing muscles and stimulating blood circulation is as follows: 21g of safflower, 79g of vinegar nutgrass galingale rhizome, 105g of scalding rhizoma cibotii, 52g of cortex caryophylli, 79g of Chinese starjasmine stem, 79g of lycopodium clavatum, 79g of herba lycopi, 105g of mistletoe, 79g of suberect spatholobus stem and 13g of calcined native copper, and the preparation method comprises: pulverizing Carthami flos, rhizoma Cyperi, rhizoma Cibotii, and cortex Periplocae Radicis into fine powder, and sieving. Decocting Pyritum in water for 2 hr, adding caulis Trachelospermi, herba Lycopi, herba Visci, and caulis Spatholobi, decocting for 3 hr and 2 hr respectively, mixing decoctions, filtering, standing filtrate for 8-10 hr, concentrating supernatant into soft extract with relative density of 1.25-1.35 (70deg.C), adding 257g of above powder and 39g of maltose, granulating, drying, and pressing into 1000 tablets, or sugar coating or film coating.
The existing national standard preparation method of the tablet for relaxing muscles and stimulating blood circulation comprises the steps of granulating medicinal powder, corn starch, extract and maltose, wherein the total content of the extract and the maltose of the variety is about 37%, and the granulating method comprises the following steps:
(1) The medicinal powder, corn starch, extract and maltose are adopted for high-speed stirring granulation, and the materials prepared by the method are too viscous, and the hardness and friability of the plain tablets do not meet the coating requirement;
(2) The medicinal powder, corn starch, extract and maltose are extruded and granulated, the extract and the maltose are unevenly dispersed, the granularity of the granules is poor, the fine powder is more, and the prepared granules are loose;
(3) The method directly dries, pulverizes and then granulates the medicinal powder, the extract and the maltose, and the method has the problems that excessive auxiliary materials are used, the unit content is diluted, and the curative effect of the product is affected, so that the prepared granules have the defect of poor formability due to the formula and the process reasons, and the unit content of the product is reduced.
Disclosure of Invention
The invention aims to provide a preparation method of a tablet for relaxing muscles and stimulating blood circulation, which aims to solve the problems.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a preparation method of a tablet for relaxing muscles and stimulating blood circulation comprises the following steps:
(1) Firstly, crushing and mixing safflower, vinegar-processed nutgrass galingale rhizome and scalding rhizoma cibotii; the cortex Periplocae Radicis is singly crushed and mixed to obtain two kinds of fine powder;
(2) Decocting calcined Pyritum in water, soaking, adding caulis Trachelospermi, herba Lycopi, herba Visci, caulis Spatholobi and herba Lycopodii, decocting, mixing decoctions, filtering, standing, and concentrating the supernatant under reduced pressure to obtain soft extract;
(3) Crushing sucrose: taking part of sucrose, and crushing the sucrose into sucrose powder for later use by a crusher;
(4) Heating extract and maltose: heating the thick paste and the maltose obtained in the step (2) respectively, and filtering for later use;
(5) Preparing syrup: adding purified water (the dosage is 40% of the sucrose), stirring, heating, stirring while heating, boiling, and making into syrup with relative density of 1.28-1.30 (100deg.C);
(6) Granulating, drying, tabletting and coating: mixing the fine powder obtained in the step (1), 24.7g of sucrose powder obtained in the step (3) and 2.4-2.5g of corn starch by using a double-power quick-release mixer uniformly, adding the extract obtained in the step (4), maltose and 43.3-61.3g of syrup obtained in the step (5) (the sucrose powder is used as a filling agent and an adhesive, the sucrose slurry is used as an adhesive, the hardness and the formability of the tablet are improved), stirring uniformly, preparing a soft material, extruding and sieving the soft material by using a swinging type granulator, granulating, drying, granulating by using the swinging type granulator, adding magnesium stearate, talcum powder, mixing, tabletting and coating.
As a preferable technical scheme: in the step (1), a low-temperature pulverizer is adopted for pulverization, and the pulverization grain diameter is 100 meshes. The medicinal materials are crushed by using a low-temperature crusher, so that active ingredients in the medicinal materials are furthest preserved. The medicinal powders are respectively mixed, so that the uniformity of the raw materials is ensured. Concentrating the concentrated liquid medicine under reduced pressure, shortening heating time, and improving curative effect.
As a preferable technical scheme: in the step (2), calcined native copper is decocted for 2 hours, chinese starjasmine stem, herba lycopi, mistletoe, suberect spatholobus stem and lycopodium clavatum are decocted for two times, wherein the first time is 3 hours, the second time is 2 hours, filtering is carried out after each time of decoction, and soaking is carried out before the decoction. Before the extraction of the medicinal materials, the medicinal materials are soaked, so that the ingredients which are difficult to decoct are ensured to be decocted.
As a preferable technical scheme: in the step (4), the addition amount of the maltose is 5.6% of the total mass of the raw material medicines.
As a preferable technical scheme: in the step (6), the addition amount of the corn starch is 0.347-0.361% of the total mass of the raw material medicine; or: the addition amount is 2.4-2.5g.
As a preferable technical scheme: in the step (6), the adding amount of the sucrose syrup is 6.26-8.87% of the total mass of the raw material medicines. The method comprises the steps of carrying out a first treatment on the surface of the Or: the addition amount is 43.3-61.3g.
The auxiliary materials also comprise magnesium stearate and talcum powder, wherein the addition amount of the magnesium stearate and the talcum powder is 0.578-0.651% of the total mass of the raw material medicines respectively; or: the addition amount is 4.0-4.5g.
As one of the most important invention points, a double-power quick-release mixer is used, so that the problems that the traditional medicine mixer can not uniformly distribute active ingredients of medicines in each medicine and the molding and the medicine effect are poor due to uneven dispersion of the medicine mixer and the liquid raw materials/auxiliary materials when the traditional medicine mixer mixes solid medicine powder and the liquid raw materials/auxiliary materials are solved, and meanwhile, the problems that the mixing time of materials is difficult to control due to high-speed stirring and granulating in the traditional method and the prepared granules are too thick or too thin and the molding problem is caused are solved, and the method has the following advantages:
(1) The mixing uniformity between the liquid raw material and the solid raw material/auxiliary material can be effectively ensured; (2) the mixing speed is high, and all the components are uniformly stirred; (3) the effectiveness of the drugs in the same batch is the same; (4) The mixed extrusion power is strong, and the prepared particles tightly induce the viscosity of the material; (5) Satisfies the ratio of solid powder to liquid raw material/auxiliary material, and the adhesive is added to the maximum extent when the liquid occupies a large area, thereby ensuring the formability.
As another most important invention point of the present invention, the following advantages are obtained by using the extract as the adhesive:
(1) Solves the problems that the extractum is dried to be used as extractum powder in the traditional technology, and a large amount of auxiliary materials are repeatedly added to dilute the content of units; (2) The method shortens the heating time of the extractum, reduces the loss of active ingredients caused by heating, thereby improving the curative effect of the product (the content of finished products in the traditional granulating process is 83-158 mug/tablet, the average value is 118 mug/tablet, and the content of finished products after granulating the extractum is 105-250 mug/tablet, the average value is 168 mug/tablet; 3) omits the paste drying process and the crushing process in the traditional process, shortens the production period for 3 days, and obviously reduces the production cost.
In addition, the invention selects common auxiliary material sucrose to ensure the molding effect on the basis of maltose and extract, and meanwhile, the extract is used as an adhesive, compared with the traditional method of granulating after drying and crushing the extract into powder, the dosage of syrup is reduced by 32-38g; magnesium stearate and talcum powder are used as lubricants to ensure the fluidity and formability of the granules.
The comparison of the method of the invention (abbreviated as the invention) of crude drug powder+extract granulation+double-power quick-discharge mixer mixing with the traditional method of drying and crushing crude drug powder, extract and maltose into extract powder+trough-type mixer mixing (abbreviated as the prior art) is shown in the following table 1:
table 1 comparison of the preparation of the tablets for relaxing muscles and stimulating blood circulation by different processes
Compared with the prior art, the invention has the advantages that: the preparation method of the invention can reduce the production procedures (extract drying), reduce the auxiliary material dosage and improve the unit content on the basis of ensuring uniform addition of maltose and extract, thereby improving the curative effect of the product and the formability of the particles.
Detailed Description
The invention will be further illustrated with reference to examples.
Example 1:
a preparation method of a tablet for relaxing muscles and stimulating blood circulation,
the raw materials of the preparation are, calculated by 1000 tablets, 21g of safflower, 79g of vinegar nutgrass galingale rhizome, 105g of scalding cibotium rhizome, 52g of cortex caryophylli, 79g of Chinese starjasmine stem, 79g of lycopodium clavatum, 79g of herba lycopi, 105g of mistletoe, 79g of suberect spatholobus stem and 13g of calcined native copper,
the preparation method comprises the following steps:
(1) Firstly, mixing safflower, vinegar nutgrass galingale rhizome and scalding rhizoma cibotii in the formula, crushing the mixture into 100-mesh fine powder at low temperature, and mixing; pulverizing cortex Periplocae Radicis into 100 mesh fine powder at low temperature to obtain two kinds of fine powder;
(2) Adding water into calcined Pyritum, soaking, decocting for 2 hr, adding caulis Trachelospermi, herba Lycopi, herba Visci, caulis Spatholobi and herba Lycopodii, decocting for 3 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, standing, and concentrating the supernatant under reduced pressure to obtain soft extract (1.25/70deg.C).
(3) Crushing sucrose: taking part of sucrose, and crushing the sucrose into sucrose powder for later use by a crusher;
(4) Heating extract and maltose: heating the thick paste obtained in the step (2) and 39g of maltose respectively, and filtering for later use.
(5) Preparing syrup: adding purified water (40% of sucrose), stirring, heating while stirring, boiling, and making into syrup with relative density of 1.28 (100deg.C).
(6) Granulating, drying, tabletting and coating: mixing the fine powder obtained in the step (1), 24.7g of sucrose powder and 2.4g of corn starch uniformly by using a double-power quick-release mixer (in the embodiment, the double-power quick-release mixer is purchased from Tianshuihua round pharmaceutical equipment science and technology, the equipment model is HCS-350, the frequency is 50HZ when in use), adding 43.3g of thick paste and maltose prepared in the step (4), stirring uniformly to prepare soft materials, extruding and sieving the soft materials by using a swinging granulator, granulating, drying, granulating by using the swinging granulator, adding a proper amount of magnesium stearate and talcum powder, and mixing, tabletting and coating the soft materials by 4.0g respectively;
the unit content of the final product obtained in this example was 227. Mu.g/tablet.
Example 2:
a preparation method of a tablet for relaxing muscles and stimulating blood circulation,
the raw materials of the preparation are, calculated by 1000 tablets, 21g of safflower, 79g of vinegar nutgrass galingale rhizome, 105g of scalding cibotium rhizome, 52g of cortex caryophylli, 79g of Chinese starjasmine stem, 79g of lycopodium clavatum, 79g of herba lycopi, 105g of mistletoe, 79g of suberect spatholobus stem and 13g of calcined native copper,
the preparation method comprises the following steps:
(1) Firstly, mixing safflower, vinegar nutgrass galingale rhizome and scalding rhizoma cibotii in the formula, crushing the mixture into 100-mesh fine powder at low temperature, and mixing; pulverizing cortex Periplocae Radicis into 100 mesh fine powder at low temperature to obtain two kinds of fine powder;
(2) Adding water into calcined Pyritum, soaking, decocting for 2 hr, adding caulis Trachelospermi, herba Lycopi, herba Visci, caulis Spatholobi and herba Lycopodii, decocting for 3 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, standing, and concentrating the supernatant under reduced pressure to obtain soft extract (1.3/70deg.C).
(3) Crushing sucrose: taking part of sucrose, and crushing the sucrose into sucrose powder for later use by a crusher;
(4) Heating extract and maltose: heating the thick paste obtained in the step (2) and 39g of maltose respectively, and filtering for later use.
(5) Preparing syrup: taking sucrose, adding purified water (the dosage is 40% of the sucrose), stirring, heating, stirring while heating, boiling, and making into syrup with relative density of 1.29 (100deg.C).
(6) Granulating, drying, tabletting and coating: mixing the fine powder obtained in the step (1), 24.7g of sucrose powder and 2.45g of corn starch uniformly by using a double-power quick-release mixer (in the embodiment, the double-power quick-release mixer is purchased from Tianshuihua round pharmaceutical equipment science and technology, the equipment model is HCS-350, the frequency is set to be 50HZ when in use), adding 52.3g of thick paste and maltose treated in the step (4), stirring uniformly to prepare soft materials, extruding and sieving the soft materials by using a swinging type granulator, granulating, drying, granulating by using the swinging type granulator, adding a proper amount of magnesium stearate and talcum powder, and mixing, tabletting and coating 4.25g of each to obtain the finished product;
the unit content of the final product obtained in this example was 209. Mu.g/tablet.
Example 3:
a preparation method of a tablet for relaxing muscles and stimulating blood circulation,
the raw materials of the preparation are, calculated by 1000 tablets, 21g of safflower, 79g of vinegar nutgrass galingale rhizome, 105g of scalding cibotium rhizome, 52g of cortex caryophylli, 79g of Chinese starjasmine stem, 79g of lycopodium clavatum, 79g of herba lycopi, 105g of mistletoe, 79g of suberect spatholobus stem and 13g of calcined native copper,
the preparation method comprises the following steps:
(1) Firstly, mixing safflower, vinegar nutgrass galingale rhizome and scalding rhizoma cibotii in a formula, crushing the mixture into 100-mesh fine powder at low temperature, mixing the fine powder, and independently crushing cortex xiang into 100-mesh fine powder at low temperature, and mixing the fine powder to obtain two kinds of fine powder;
(2) Adding water into calcined Pyritum, soaking, decocting for 2 hr, adding caulis Trachelospermi, herba Lycopi, herba Visci, caulis Spatholobi and herba Lycopodii, decocting for 3 hr for the first time and 2 hr for the second time, mixing decoctions, filtering, standing, and concentrating the supernatant under reduced pressure to obtain soft extract (1/35/70deg.C).
(3) Crushing sucrose: taking part of sucrose, and crushing the sucrose into sucrose powder for later use by a crusher;
(4) Heating extract and maltose: heating the thick paste obtained in the step (2) and 39g of maltose respectively, and filtering for later use.
(5) Preparing syrup: adding purified water (40% of sucrose), stirring, heating while stirring, boiling, and making into syrup with relative density of 1.30 (100deg.C).
(6) Granulating, drying, tabletting and coating: mixing the fine powder obtained in the step (1), 24.7g of sucrose powder and 2.5g of corn starch uniformly by using a double-power quick-release mixer (in the embodiment, the double-power quick-release mixer is purchased from Tianshuihua round pharmaceutical equipment science and technology, the equipment model is HCS-350, the frequency is set to be 50HZ when in use), adding 61.3g of thick paste and maltose treated in the step (4), stirring uniformly to prepare soft materials, extruding and sieving the soft materials by using a swinging type granulator, granulating, drying, granulating by using the swinging type granulator, adding 4.5g of magnesium stearate and talcum powder respectively, mixing, tabletting and coating to obtain the finished product;
the unit content of the final product obtained in this example was 193.2. Mu.g/tablet.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (5)
1. A preparation method of a tablet for relaxing muscles and stimulating blood circulation is characterized by comprising the following steps:
the 1000 tablets are prepared, the raw materials of the tablet comprise 21g of safflower, 79g of vinegar nutgrass galingale rhizome, 105g of scalding rhizoma cibotii, 52g of cortex caryophylli, 79g of Chinese starjasmine stem, 79g of lycopodium clavatum, 79g of herba lycopi, 105g of mistletoe, 79g of suberect spatholobus stem and 13g of calcined native copper,
(1) Firstly, crushing and mixing safflower, vinegar-processed nutgrass galingale rhizome and scalding rhizoma cibotii; separately pulverizing cortex Periplocae Radicis to obtain two kinds of fine powder;
(2) Decocting calcined Pyritum in water, soaking, adding caulis Trachelospermi, herba Lycopi, herba Visci, caulis Spatholobi and herba Lycopodii, decocting, mixing decoctions, filtering, standing, and concentrating the supernatant under reduced pressure to obtain soft extract;
(3) Crushing sucrose: taking part of sucrose, and crushing the sucrose into sucrose powder for later use by a crusher;
(4) Heating extract and maltose: heating the thick paste and the maltose obtained in the step (2) respectively, and filtering for later use;
(5) Preparing syrup: adding purified water into sucrose, stirring, heating, stirring while heating, boiling, and making into syrup with relative density of 1.28-1.30;
(6) Granulating, drying, tabletting and coating: mixing the fine powder obtained in the step (1), 24.7g of sucrose powder obtained in the step (3) and 2.4-2.5g of corn starch by using a double-power quick-release mixer uniformly, adding the extract obtained in the step (4), maltose and 43.3-61.3g of syrup obtained in the step (5), stirring uniformly, preparing a soft material, extruding and sieving the soft material by using a swinging type granulator, granulating, drying, granulating by using the swinging type granulator, adding magnesium stearate and talcum powder, mixing, tabletting and coating.
2. The method for preparing the tablet for relaxing muscles and tendons and promoting blood circulation according to claim 1, which is characterized in that: in the step (1), a low-temperature pulverizer is adopted for pulverization, and the pulverization grain diameter is 100 meshes.
3. The method for preparing the tablet for relaxing muscles and tendons and promoting blood circulation according to claim 1, which is characterized in that: in the step (2), calcined native copper is decocted for 2 hours, chinese starjasmine stem, herba lycopi, mistletoe, suberect spatholobus stem and lycopodium clavatum are decocted for two times, wherein the first time is 3 hours, the second time is 2 hours, filtering is carried out after each time of decoction, and soaking is carried out before the decoction.
4. The method for preparing the tablet for relaxing muscles and tendons and promoting blood circulation according to claim 1, which is characterized in that: in the step (4), the addition amount of the maltose is 5.6% of the total mass of the raw material medicines.
5. The method for preparing the tablet for relaxing muscles and tendons and promoting blood circulation according to claim 1, which is characterized in that: in the step (6), the addition amount of the magnesium stearate and the talcum powder is 0.578-0.651% of the total mass of the raw material medicines respectively.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883635A (en) * | 2006-05-30 | 2006-12-27 | 湖南长沙宝鉴生物工程有限公司 | Tendon-relaxing blood circulation-activating capsule and preparation process thereof |
| CN102058748A (en) * | 2009-11-13 | 2011-05-18 | 上海玉森新药开发有限公司 | Method for preparing muscle relaxing and blood circulation stimulating capsules |
| CN104800476A (en) * | 2015-04-11 | 2015-07-29 | 河南金鸿堂制药有限公司 | Preparation method of muscle-relaxing and blood-circulation-promoting tablets |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883635A (en) * | 2006-05-30 | 2006-12-27 | 湖南长沙宝鉴生物工程有限公司 | Tendon-relaxing blood circulation-activating capsule and preparation process thereof |
| CN102058748A (en) * | 2009-11-13 | 2011-05-18 | 上海玉森新药开发有限公司 | Method for preparing muscle relaxing and blood circulation stimulating capsules |
| CN104800476A (en) * | 2015-04-11 | 2015-07-29 | 河南金鸿堂制药有限公司 | Preparation method of muscle-relaxing and blood-circulation-promoting tablets |
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