CN115137786A - A capsule containing six ingredients with rehmanniae radix and its preparation method - Google Patents
A capsule containing six ingredients with rehmanniae radix and its preparation method Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a six-ingredient rehmannia capsule and a preparation method thereof, wherein the preparation method comprises the following steps: decocting Poria with water, and concentrating to obtain Poria soft extract; extracting Corni fructus with ethanol under reflux, and concentrating to obtain soft extract; distilling cortex moutan with steam, and sequentially crystallizing and drying the distillate to obtain cortex moutan extract fine powder; mixing the water solution of cortex moutan with residue of cortex moutan, residue of Corni fructus, radix rehmanniae Preparata, rhizoma Dioscoreae and Alismatis rhizoma, decocting in water for three times, mixing the decoctions, filtering, passing through macroporous adsorbent resin, eluting with 60-80% ethanol, collecting eluate, and concentrating to obtain composition soft extract; mixing the composition soft extract, poria soft extract and Corni fructus soft extract, drying under reduced pressure, pulverizing, adding cortex moutan extract fine powder and adjuvants, and making into capsule to obtain LIUWEIDIHUANG Capsule. The method improves medicine purity, and reduces production cost and energy consumption.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a six-ingredient rehmannia capsule and a preparation method thereof.
Background
The six-ingredient rehmannia capsules are famous ancient prescription medicines applied for hundreds of years, are clinically well known at present, consist of six traditional Chinese medicines of prepared rehmannia root, chinese yam, dogwood, oriental waterplantain rhizome, tree peony bark and Indian buead, are mainly used for treating kidney-yin deficiency, dizziness and tinnitus, soreness and weakness of waist and knees, bone steaming and tidal fever, night sweat and spermatorrhea and diabetes, and are deeply accepted by patients due to definite curative effect.
The prepared rehmannia root is used as a monarch drug in the prescription for nourishing yin and tonifying kidney, and replenishing body fluid and benefiting marrow; cornus officinalis has effects of nourishing liver and kidney and astringing essence, chinese yam, rhizoma Dioscoreae, as a ministerial drug, can tonify spleen yin and secure essence. The three herbs are combined to tonify liver, kidney and spleen, but they are mainly used to tonify kidney yin and tonify deficiency to treat the root cause. It is combined with the actions of purging kidney and promoting diuresis, and preventing the greasy taste of prepared rhizome of rehmannia; cortex moutan is used for purging liver fire and treating Corni fructus with acid; <xnotran> , , , , . </xnotran> The whole formula is matched with three supplements and three purges, and the supplement is mainly used. Liver, spleen and kidney tonify yin, and they supplement kidney yin and supplement each other. The formula is rigorous and is a classic famous formula for Tongbu open and shut.
The method for preparing the Liuwei Dihuang capsules in the prior art generally extracts the active ingredients in the medicament in a water boiling and alcohol extraction mode, has low medicament yield, large energy consumption, high cost, certain pollution to the environment, difficult quality control and no accordance with the modern production requirement of the traditional Chinese medicine.
In view of the above problems, it is an urgent technical problem to be solved by those skilled in the art to develop a novel method for preparing Liuwei Dihuang capsules.
Disclosure of Invention
The first purpose of the invention is to provide a preparation method of a capsule of six ingredients with rehmannia, which reduces the production cost and the production energy consumption;
the second purpose of the invention is to provide a capsule of six ingredients with rehmannia, which improves the purity of the medicine and the content of active ingredients of each medicine.
The invention provides a preparation method of a capsule of six ingredients with rehmannia, which comprises the following steps:
s1, adding water into poria cocos, decocting, and concentrating to obtain poria cocos thick paste;
s2, adding ethanol into the dogwood fruit pulp, performing reflux extraction, and concentrating to obtain soft extract of the dogwood fruit pulp;
s3, distilling the tree peony bark by using steam, and crystallizing and drying distillate in sequence to obtain tree peony bark extract fine powder;
s4, mixing the water solution obtained after distilling the tree peony bark with tree peony bark dregs, dogwood dregs, prepared rehmannia root, chinese yam and rhizoma alismatis, adding water, decocting for three times, mixing decoction filtrates obtained in the three times, filtering, passing through macroporous adsorption resin, eluting by using 60-80% ethanol, collecting eluent, and concentrating to obtain composition thick paste;
s5, mixing the composition thick paste, the poria cocos thick paste and the soft paste of the dogwood fruit pulp, drying under reduced pressure, crushing, adding the fine powder of the moutan bark extract and auxiliary materials, and encapsulating to obtain a six-ingredient rehmannia capsule;
preferably, in step S4, during the decoction, the amount of water added for the first time is 5-7 times, the amount of water added for the second time is 3-5 times, and the amount of water added for the third time is 3-5 times;
wherein, the steps S1, S2 and S3 are not limited in sequence.
Preferably, in the technical scheme, the capsule of six ingredients with rehmannia comprises the following raw medicinal materials in parts by weight: 1350-1450 parts of prepared rehmannia root, 680-720 parts of dogwood fruit wine, 500-550 parts of tree peony bark, 680-720 parts of Chinese yam, 500-550 parts of tuckahoe and 500-550 parts of rhizoma alismatis. And specifically, one can choose: 1408 parts of prepared rehmannia root, 704 parts of alcohol pulp dogwood fruit, 528 parts of moutan bark, 704 parts of Chinese yam, 528 parts of tuckahoe and 528 parts of rhizoma alismatis.
Preferably, in the present technical solution, step S1 specifically includes: pulverizing 100-120 parts of Poria to 70-90 mesh, decocting the residue and the rest Poria in water for three times, each for 25-35min, mixing filtrates, and concentrating to obtain Poria soft extract;
preferably, during the decoction, the water is added for the first time in an amount which is 5 to 7 times that of the first time, the water is added for the second time in an amount which is 3 to 5 times that of the second time, and the water is added for the third time in an amount which is 3 to 5 times that of the third time.
The poria cocos is smashed and then decocted, so that the dissolution of active ingredients in the raw material medicines can be effectively improved, the bioavailability of the raw material medicines is further improved, and in addition, in the decocting process, the water adding amount is reasonably controlled, so that the active ingredients can be extracted to the maximum extent, and ineffective ingredients can be removed.
Preferably, in the present technical solution, step S2 specifically includes: extracting Corni fructus with ethanol under reflux twice for 55-65min, filtering, collecting residues, mixing filtrates, and concentrating to obtain soft extract.
When the effective components in the dogwood fruit wine are extracted, the dosage of the ethanol is not particularly limited, and specifically, the dosage of the ethanol required by each gram of the dogwood fruit wine can be 8-10mL. The method of extracting fructus Corni with wine by several times can ensure that effective components in fructus Corni with wine can be dissolved out sufficiently.
Preferably, in the present technical solution, step S3 specifically includes: distilling cortex moutan with steam, adding hydrochloric acid solution into the distillate to crystallize cortex moutan extract, filtering, washing, drying, and grinding the obtained cortex moutan extract crystal to obtain cortex moutan extract fine powder;
wherein, during the drying, a low-temperature drying method is adopted, the invention is not particularly limited with regard to the specific value of the temperature, and the temperature can be selectively controlled to be 55-65 ℃;
the grinding is mainly to ensure that the fine powder of the moutan bark extract is mixed with each thick paste more uniformly, namely the grinding degree of the materials in the grinding process is not strictly limited, and the materials can be specifically ground to 90-110 meshes.
In the invention, the hydrochloric acid solution can promote the crystallization of the moutan bark extract, and in order to ensure that the moutan bark extract can completely and effectively separate out the crystals, the amount of the hydrochloric acid solution required by each gram of moutan bark is 0.008-0.012mL, and the concentration of the hydrochloric acid solution is 0.5-1.5mol/L.
Preferably, in step S4, the amount of the 60-80% ethanol is 1.5-2.5 times of the column volume; the type of the macroporous adsorption resin is preferably an adsorbent with HPD-100 divinylbenzene as a framework structure. When the filtrate passes through the macroporous adsorption resin column, the filtrate is firstly filtered and discharged to filter out part of larger impurities, and then passes through the macroporous adsorption resin column, so that the dosage of the eluent can be obviously reduced during elution, and the pollution to the environment is further reduced.
Preferably, the reduced pressure drying and pulverization in step S5 may be replaced by boiling granulation.
The capsule of six ingredients with rehmannia prepared by the method also belongs to the protection scope of the invention.
The preparation method of the capsule of six ingredients with rehmannia of the invention at least has the following technical effects:
1. in the process of mixing and decocting the distilled aqueous solution of the tree peony bark, the tree peony bark dregs, the wine dogwood dregs, the prepared rehmannia root, the Chinese yam and the oriental waterplantain rhizome for multiple times, the dosage of water added each time is reasonably controlled, and the effective components can be fully dissolved out; in addition, in the process of refining the decoction filtrate by using macroporous adsorption resin, the filtrate is firstly filtered, so that the dosage of ethanol in the elution process can be effectively reduced, and further, the production energy consumption and the pollution to the environment are reduced;
2. the extraction method of each raw material medicine is subjected to screening of a large number of process conditions, so that the most suitable process conditions are determined, the technical effect of the product is ensured, and the bioavailability of each raw material medicine is effectively improved;
3. the preparation method of the capsule of six ingredients with rehmannia of the invention improves the purity of the medicine and the content of the active ingredients of each medicine, reduces the production cost and the production energy consumption, simultaneously reduces the pollution degree to the environment, realizes the requirements of low carbon and environmental protection, and meets the production requirements of modernization of traditional Chinese medicine.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a report of the inspection of the Liuwei Dihuang capsules prepared in example 1;
FIG. 2 is a report of the inspection of the Liuwei Dihuang capsules prepared in example 2;
FIG. 3 is a report of the inspection of the Liuwei Dihuang capsules prepared in example 3;
FIG. 4 is a chromatogram of Liuwei Dihuang capsules prepared in example 1 of the present invention;
FIG. 5 is a chromatogram of Liuwei Dihuang capsules prepared in example 2 of the present invention.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular forms also include the plural forms unless the context clearly dictates otherwise, and further, it is understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Each portion in the following examples is 1g.
Example 1
The raw material medicinal materials comprise:
1408 parts of prepared rehmannia root, 704 parts of wine dogwood fruit, 528 parts of moutan bark, 704 parts of Chinese yam, 528 parts of tuckahoe and 528 parts of rhizoma alismatis;
the preparation method comprises the following steps:
s11, crushing 110 parts of poria cocos to 80 meshes, adding water into the sieved part and the rest poria cocos, decocting for three times for 30min each time, wherein the amount of the water added for the first time is 6 times that of the rest poria cocos, the amount of the water added for the second time is 4 times that of the rest poria cocos, and the water added for the third time is 4 times that of the rest poria cocos, merging the filtrates, and concentrating to obtain a poria cocos thick paste;
s12, adding ethanol into the dogwood fruit, performing reflux extraction twice, wherein the amount of the ethanol used for each time is 2800mL, the ethanol used for each time is 60min, filtering, reserving dregs for later use, combining the filtrates, and concentrating to obtain a dogwood fruit thick paste;
s13, distilling the tree peony bark by using water vapor, adding 0.01mL1.0mol/L hydrochloric acid solution into the collected distillate to crystallize the tree peony bark extract, and sequentially filtering, washing, drying and grinding the obtained tree peony bark extract crystals, wherein the drying temperature is controlled to be 60 ℃, and the grinding is performed, so that the materials are ground to 100 meshes to obtain tree peony bark extract fine powder;
s14, mixing the water solution obtained after distilling the tree peony bark with tree peony bark dregs, dogwood dregs, prepared rehmannia root, chinese yam and rhizoma alismatis, adding water, decocting for three times, mixing decoction filtrates obtained in the three times, filtering, passing through macroporous adsorption resin, eluting by using 70% ethanol, wherein the using amount of the 70% ethanol is 2 times of the column volume, collecting eluent, and concentrating to obtain composition thick paste;
s15, mixing the composition thick paste, the poria cocos thick paste and the soft paste of the dogwood fruit pulp, drying under reduced pressure, crushing, adding the fine powder of the moutan bark extract and auxiliary materials, and encapsulating to obtain the six-ingredient rehmannia capsules.
Example 2
The raw material medicinal materials comprise:
1408 parts of prepared rehmannia root, 704 parts of wine dogwood fruit, 528 parts of moutan bark, 704 parts of Chinese yam, 528 parts of tuckahoe and 528 parts of rhizoma alismatis;
the preparation method comprises the following steps:
s21, crushing 110 parts of poria cocos to 70 meshes, adding water to the sieved part and the rest poria cocos, decocting for three times, each time for 25min, wherein the water is added 7 times, 4 times and 3 times respectively, mixing the filtrates, and concentrating to obtain a poria cocos thick paste;
s22, adding ethanol into the dogwood fruit pulp, performing reflux extraction twice, wherein the amount of the ethanol used in each time is 15mL, the ethanol used in each time is 55min, filtering, keeping medicine residues for later use, combining the filtrates, and concentrating to obtain a thick paste of the dogwood fruit pulp;
s23, distilling the tree peony bark with water vapor, adding 5mL1.5mol/L hydrochloric acid solution into the collected distillate to crystallize the tree peony bark extract, and sequentially filtering, washing, drying and grinding the obtained tree peony bark extract crystals, wherein the temperature is controlled to be 50-60 during drying, and the materials are ground to 80 meshes during grinding to obtain tree peony bark extract fine powder;
s24, mixing the water solution obtained after distilling the tree peony bark with tree peony bark dregs, dogwood dregs, prepared rehmannia root, chinese yam and rhizoma alismatis, adding water, decocting for three times, mixing decoction filtrates obtained in the three times, filtering, passing through macroporous adsorption resin, eluting by using 60% ethanol, wherein the dosage of the 60% ethanol is 2.5 times of the column volume, collecting eluent, and concentrating to obtain composition thick paste;
s25, mixing the composition thick paste, the poria cocos thick paste and the soft paste of the dogwood fruit pulp, drying under reduced pressure, crushing, adding the fine powder of the moutan bark extract and auxiliary materials, and encapsulating to obtain the six-ingredient rehmannia capsules.
Example 3
The raw material medicinal materials comprise:
1408 parts of prepared rehmannia root, 704 parts of wine dogwood fruit, 528 parts of tree peony bark, 704 parts of Chinese yam, 528 parts of tuckahoe and 528 parts of rhizoma alismatis;
the preparation method comprises the following steps:
s31, crushing 110 parts of poria cocos to 90 meshes, adding water into the sieved part and the rest poria cocos, decocting for three times, 35min each time, wherein the amount of the water added for the first time is 5 times that of the rest poria cocos, the amount of the water added for the second time is 5 times that of the rest poria cocos, and the amount of the water added for the third time is 4 times that of the rest poria cocos, combining filtrates, and concentrating to obtain a poria cocos thick paste;
s32, adding ethanol into the dogwood pulp, performing reflux extraction twice, wherein the amount of the ethanol used in each time is 3000mL, the ethanol used in each time is 65min, filtering, keeping medicine residues for later use, combining the filtrates, and concentrating to obtain a thick paste of the dogwood pulp;
s33, distilling the tree peony bark with water vapor, adding 0.01mL0.8mol/L hydrochloric acid solution into the collected distillate to crystallize the tree peony bark extract, and sequentially filtering, washing, drying and grinding the tree peony bark extract crystals, wherein the drying temperature is controlled at 60 ℃, and the grinding is performed, and the materials are crushed to 100 meshes to obtain tree peony bark extract fine powder;
s34, mixing the water solution obtained after distilling the tree peony bark with tree peony bark dregs, dogwood dregs, prepared rehmannia root, chinese yam and rhizoma alismatis, adding water, decocting for three times, mixing decoction filtrates obtained in the three times, filtering, passing through macroporous adsorption resin, eluting by using 80% ethanol, wherein the using amount of the 80% ethanol is 1.5 times of the column volume, collecting eluent, and concentrating to obtain composition thick paste;
s35, mixing the composition thick paste, the poria cocos thick paste and the soft paste of the dogwood fruit pulp, drying under reduced pressure, crushing, adding the fine powder of the moutan bark extract and auxiliary materials, and encapsulating to obtain the six-ingredient rehmannia capsules.
Comparative example 1
The raw material medicinal materials comprise:
1408 parts of prepared rehmannia root, 704 parts of wine dogwood fruit, 528 parts of tree peony bark, 704 parts of Chinese yam, 528 parts of tuckahoe and 528 parts of rhizoma alismatis;
the preparation method comprises the following steps:
s1, crushing 110 parts of poria cocos to 80 meshes, adding water into the sieved part and the rest poria cocos, decocting for three times, 30min each time, wherein the amount of the water added for the first time is 5 times that of the rest poria cocos, the amount of the water added for the second time is 3 times that of the rest poria cocos, and the amount of the water added for the third time is 3 times that of the rest poria cocos, combining the filtrates, and concentrating to obtain a poria cocos thick paste;
s2, adding ethanol into the dogwood fruit, performing reflux extraction twice, wherein the amount of the ethanol used in each time is 2800mL, the ethanol used in each time is 60min, filtering, reserving dregs for later use, combining the filtrates, and concentrating to obtain a dogwood fruit thick paste;
s3, distilling the tree peony bark with water vapor, adding 0.01mL1.0mol/L hydrochloric acid solution into the collected distillate to crystallize the tree peony bark extract, and sequentially filtering, washing, drying and grinding the obtained tree peony bark extract crystals, wherein the drying temperature is controlled to be 60 ℃, and the grinding is performed, and the materials are ground to 100 meshes to obtain tree peony bark extract fine powder;
s4, mixing the water solution obtained after distilling the tree peony bark with tree peony bark dregs, dogwood dregs, prepared rehmannia root, chinese yam and rhizoma alismatis, adding water, decocting for three times, mixing decoction filtrates obtained in the three times, filtering, passing through macroporous adsorption resin, eluting by using 70% ethanol, wherein the using amount of the 70% ethanol is 3 times of the column volume, collecting eluent, and concentrating to obtain composition thick paste;
and S5, mixing the composition thick paste, the poria cocos thick paste and the soft paste of the dogwood fruit pulp, drying under reduced pressure, crushing, adding the fine powder of the moutan bark extract and auxiliary materials, and encapsulating to obtain the six-ingredient rehmannia capsules.
The invention respectively carries out finished product inspection on the Liuwei Dihuang capsules prepared in examples 1-3, and the inspection reports are shown in figures 1-3.
As can be seen from the figure, the indexes of the Liuwei Dihuang capsules prepared in the embodiments 1-3 of the invention, such as the property, the content and the like, all meet the corresponding quality standards.
Meanwhile, in order to further study the extraction rate of the effective components in each crude drug by the preparation method of the present invention, the effective components in the liuweidihuang capsules prepared in examples 1-3 and the comparative example were tested, and the test results are shown in tables 1-3.
TABLE 1 content of effective ingredient (70% ethanol) in Liuwei Dihuang capsules prepared in example 1
Table 2 content of active ingredient (60% ethanol) in the liuwei dihuang capsule prepared in example 2
Table 3 content of active ingredient (80% ethanol) in the liuwei dihuang capsule prepared in example 3
TABLE 4 contents of effective components in LIUWEIDIHUANG Capsule prepared in comparative example 1
As can be seen from tables 1 to 4, the content of the active ingredient in the liuweidihuang capsule prepared in example 1 of the present invention is significantly increased compared to the control example, which indicates that the preparation method of the present invention improves the bioavailability of the bulk drug and the purity of the drug. In addition, in the process of refining the decoction filtrate by using macroporous adsorption resin, the filtrate is firstly filtered, so that the dosage of ethanol in the elution process can be effectively reduced, and further, the production energy consumption and the pollution to the environment are reduced.
In contrast, as can be seen from comparative examples 1 to 3, when the macroporous adsorption resin is eluted, a 70% ethanol solution is preferred, and when 60% ethanol is used for extraction, the problem that paeonol cannot be effectively eluted exists, while the use of 80% ethanol increases the use amount of ethanol, which increases the production energy consumption and the pollution degree to the environment.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and these modifications or substitutions do not depart from the spirit of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A preparation method of a capsule of six ingredients with rehmannia is characterized by comprising the following steps:
s1, adding water into poria cocos, decocting, and concentrating to obtain poria cocos thick paste;
s2, adding ethanol into the wine dogwood pulp, performing reflux extraction, and concentrating to obtain a wine dogwood pulp thick paste;
s3, distilling the tree peony bark by using steam, and crystallizing and drying distillate in sequence to obtain tree peony bark extract fine powder;
s4, mixing the water solution obtained after distilling the tree peony bark with tree peony bark dregs, dogwood dregs, prepared rehmannia root, chinese yam and rhizoma alismatis, adding water, decocting for three times, mixing decoction filtrates obtained in the three times, filtering, passing through macroporous adsorption resin, eluting by using 60-80% ethanol, collecting eluent, and concentrating to obtain composition thick paste;
s5, mixing the composition thick paste, the poria cocos thick paste and the soft paste of the dogwood fruit pulp, drying under reduced pressure, crushing, adding the fine powder of the moutan bark extract and auxiliary materials, and encapsulating to obtain a six-ingredient rehmannia capsule;
preferably, in step S4, during the decoction, the amount of water added for the first time is 5-7 times, the amount of water added for the second time is 3-5 times, and the amount of water added for the third time is 3-5 times;
wherein, the steps S1, S2 and S3 are not limited in sequence.
2. The preparation method according to claim 1, wherein the Liuwei Dihuang capsule comprises the following raw medicinal materials in parts by weight: 1350-1450 parts of prepared rehmannia root, 680-720 parts of dogwood fruit wine, 500-550 parts of tree peony bark, 680-720 parts of Chinese yam, 500-550 parts of tuckahoe and 500-550 parts of rhizoma alismatis.
3. The preparation method according to claim 1, wherein step S1 specifically comprises: pulverizing 100-120 parts of Poria to 70-90 mesh, decocting the rest Poria and rest Poria in water for three times (each for 25-35 min), mixing filtrates, and concentrating to obtain Poria soft extract;
preferably, during the decoction, the water is added in an amount which is 5 to 7 times that of the first time, 3 to 5 times that of the second time and 3 to 5 times that of the third time.
4. The preparation method according to claim 1, wherein the step S2 specifically comprises: extracting Corni fructus with ethanol under reflux twice, each for 55-65min, filtering, collecting residues, mixing filtrates, and concentrating to obtain soft extract.
5. The method of claim 4, wherein the amount of ethanol required per gram of wine dogwood is 8-10mL.
6. The method according to claim 1, wherein step S3 specifically comprises: distilling cortex moutan with steam, adding hydrochloric acid solution into the distillate to crystallize cortex moutan extract, filtering, washing, drying, and grinding the obtained cortex moutan extract crystal to obtain cortex moutan extract fine powder;
wherein, during the drying, the temperature is controlled to be 55-65 ℃;
during grinding, the materials are crushed to 90-110 meshes.
7. The preparation method of claim 6, wherein the amount of the hydrochloric acid solution required per gram of moutan cortex bark is 0.008-0.012mL, and the concentration of the hydrochloric acid solution is 0.5-1.5mol/L.
8. The method according to claim 1, wherein in step S4, the 60 to 80% ethanol is used in an amount of 1.5 to 2.5 column volumes;
the model of the macroporous adsorption resin is HPD-100.
9. The method of claim 1, wherein the reduced pressure drying and pulverization in step S5 can be replaced by boiling granulation.
10. A capsule of six ingredients with rehmannia, prepared by the method according to any one of claims 1 to 9.
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| CN1413711A (en) * | 2002-11-19 | 2003-04-30 | 高扬 | Preparation technology of |
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| CN1513514A (en) * | 2003-06-25 | 2004-07-21 | 四川泰华堂制药有限公司 | Method for preparing capsule of six drugs containing rehmannine |
| CN104096040A (en) * | 2013-04-14 | 2014-10-15 | 江西普正制药有限公司 | Preparation method of six-ingredient rehmannia capsules |
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
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