CN1513514A - Method for preparing capsule of six drugs containing rehmannine - Google Patents
Method for preparing capsule of six drugs containing rehmannine Download PDFInfo
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- CN1513514A CN1513514A CNA031352863A CN03135286A CN1513514A CN 1513514 A CN1513514 A CN 1513514A CN A031352863 A CNA031352863 A CN A031352863A CN 03135286 A CN03135286 A CN 03135286A CN 1513514 A CN1513514 A CN 1513514A
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- fine powder
- fructus corni
- thick paste
- poria
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Abstract
A process for preparing the six-element Dihuang capsule includes pulverizing part of tuckahoe, decocting its rest to obtain extract, extracting from dogwood fruit and concentrating to obtain extract, distilling tree peony bark to obtain crystal, decocting the rehmannia root, yam, alismatis rhizome and other dregs, purifying, mixing all together, and loading in capsules. Its advantages are high curative effect and low dosage.
Description
Technical field
The present invention relates to a kind of preparation method of LIUWEIDIHUANG JIAONANG.
Background technology
LIUWEI DIHUANG WAN side comes across the Song dynasty the earliest, is by Qian Shi the Eastern Han Dynasty to be cured shenqi pill in the holy Zhang Zhongjing " Medical Treasures of the Golden Chamber ", deducts Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, easily Radix Rehmanniae is that Radix Rehmanniae Preparata forms.The successive dynasties document is all put down in writing LIUWEI DIHUANG WAN and is made up of Radix Rehmanniae Preparata, Fructus Corni, dried Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, and implication one is made up of the Six-element medicine, and the one, bitter sweet hot degree of saltiness Six-element is various in the side.Radix Rehmanniae Preparata in the side: sweet in the mouth, slightly warm in nature, have nourishing YIN and supplementing blood, beneficial essence is filled out the function of marrow.Cure mainly the hepatic and renal YIN deficiency, soreness of the waist and knees, hectic fever hectic fever due to YIN-deficiency, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair; Fructus Corni: sour-puckery flavor, slightly warm in nature.Has liver and kidney tonifying, the function of essence astringing and desertion stemming.Cure mainly vertigo and tinnitus, soreness of waist and knee joint, sexual impotence, seminal emission, the enuresis, frequent micturition, bleeding not during menses, menorrhagia, big apogee sweating, weak body and prostration, the palpitation with a distress feeling of having a guilty conscience, the asthma of suffering from a deficiency of the kidney is had loose bowels just before dawn, quenches one's thirst; Rhizoma Dioscoreae: sweet in the mouth, property is flat.Has the spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the function of the kidney invigorating arresting seminal emission.Cure mainly diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Alismatis: sweet in the mouth, cold in nature.Have promoting diuresis to eliminate damp pathogen, treating stranguria function expels the heat-evil.Cure mainly dysuria, the edema distension, the oliguria of having loose bowels, phlegm retention is dizzy, the wet pain of pyretic stranguria, seminal emission, hyperlipemia.Cortex Moutan: bitter in the mouth, suffering, cold nature.Have clearing away heat and cooling blood, control the blood function of reducing phlegm.Cure mainly maculae caused by violent heat pathogen, haematemesis blood nosebleed, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, the tumbling down pain of injury.Poria: sweet in the mouth, light, property are flat.Has promoting diuresis to eliminate damp pathogen, the function of spleen invigorating mind calming.Cure mainly the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.LIUWEI DIHUANG WAN by above-mentioned Six-element medicine compatibility is formed has the function of enriching yin and nourishing kidney, cures mainly the deficiency of the liver and kindey that occurs in all chronic disease processes, damage of kidney-YIN, soreness of the waist and knees, dribbling urination, tooth shakes, and has a dizzy spell Hiccough and deaf, forgetful dreaminess, night sweat seminal emission, feverish sensation in the palms and soles, low grade fever after being ill, quench one's thirst osteopyrexia and fever, diseases such as dryness of the tongue pharyngalgia.Go through first, bright, clear each generation development, become the famous prescription of enriching yin and nourishing kidney.Modern existing multiple dosage form is used in clinical, as pill, granule, tablet, oral liquid, soft extract and capsule etc.
Existing LIUWEIDIHUANG JIAONANG, the prescription of employing is:
Radix Rehmanniae Preparata 176g, Cortex Moutan 66g, Rhizoma Dioscoreae 88g, Fructus Corni 88g, Rhizoma Alismatis 66g, Poria 66g.
Its preparation method is with the Cortex Moutan in the above Six-element, Fructus Corni, Poria, is ground into fine powder, sieves, and is mixed; All the other Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis three flavors decocted with water three times, first and second time each 2 hours, were 1 hour for the third time, and collecting decoction filters, and filtrate is condensed into cream; With above-mentioned powder mixes, cold drying is pulverized, and adds appropriate amount of auxiliary materials, is mixed, and incapsulates, and makes 1000 promptly again.Function with cure mainly: enriching yin and nourishing kidney.Be used for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, the sweating due to debility seminal emission is quenched one's thirst.Oral: one time 8, a twice-daily, every powder charge 0.3g.
The shortcoming of this capsule preparation method thereof is: be used as medicine because a large amount of medical materials are directly pulverized, its pesticide residues, beavy metal impurity residual quantity are higher, influence drug effect; Manufactured goods take one time 8, taking dose is big, and every effective ingredient is lower, is unfavorable for the patient.
Summary of the invention
The objective of the invention is to: provide a kind of no pesticide and beavy metal impurity residual, pastille purity height, every pharmaceutically active ingredient height, it is little once to take pharmaceutical quantities, the new method of the LIUWEIDIHUANG JIAONANG preparation that drug effect is high.
The objective of the invention is to realize by the enforcement following technical proposals:
A kind of new method of LIUWEIDIHUANG JIAONANG preparation, by each medicine treatment process of Six-element, close medicine mixing, drying, be ground into fine powder technology, and mixed powder adds adjuvant filling capsule technology composition, it is characterized in that: in each medicine treatment process, comprise: the Poria with the 1/7-2/3 recipe quantity, be ground into fine powder, the Poria decocting and concentrating of recipe quantity remainder is become the technology of thick paste; Use the solvent processing Fructus Corni, obtain extracting solution, reclaim solvent and the Fructus Corni active component that extracts is condensed into the technology of thick paste; With the Cortex Moutan steam distillation, handle distillate and make crystalline solid through cold drying, be ground into the technology of fine powder; And the medicinal residues after the medicinal residues after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation and Fructus Corni extracted decoct together, its decoction liquor is by the macroporous adsorptive resins separation and purification, collect eluent and reclaim ethanol and be condensed into thick paste, or the decoction liquor of the medicinal residues after the medicinal residues after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation and Fructus Corni extracted, directly be condensed into the technology of thick paste.
Additional technical feature:
1. describedly obtain extracting solution, be meant with the ethanol of 50-95% technical process to the Fructus Corni reflux, extract, with the solvent processing Fructus Corni.
2. describedly obtain extracting solution, be meant the technical process of extracting the Fructus Corni percolate with the alcohol percolation method of 50-95% with the solvent processing Fructus Corni.
3. described close medicine mix, dry, be ground into fine powder technology, be meant the Poria fine powder, the thick paste that the Poria decoction liquor of recipe quantity remainder is condensed into, the Fructus Corni extracting solution concentrates thick paste, mixes mutually with the thick paste that medicinal residues after medicinal residues, Fructus Corni after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation extracts decoct the gained decoction liquor jointly, dry, the technical process that is ground into fine powder.
4. add adjuvant at described mixed powder and load capsular technology, the indication mixed powder is meant the Poria fine powder, the thick paste that the Poria decoction liquor of recipe quantity remainder is condensed into, Fructus Corni extracting solution concentrate thick paste, the fine powder that mixes back drying with thick paste that medicinal residues after medicinal residues, Fructus Corni after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation extracts decoct the gained decoction liquor jointly, is ground into; It is that this medicated powder is mixed Cortex Moutan extract crystallization fine powder that indication is loaded capsule, adds the starch of 5-50%, the technical process that dextrin incapsulates again.
5. add adjuvant at described mixed powder and load capsular technology, the indication mixed powder is meant the fine powder that Poria fine powder and each thick paste of having prepared are mixed back drying, are ground into; It is with this fine powder mixing Cortex Moutan extract crystallization fine powder that gained is loaded capsule, adds the dimension crystalline cellulose of 5-30% again, the technical process that incapsulates.
6. add adjuvant at described mixed powder medicine and load capsular technology, the indication mixed powder is meant the fine powder that Poria fine powder and each thick paste of having prepared are mixed back drying, are ground into; It is that this fine powder is mixed Cortex Moutan extract crystallization fine powder that indication is loaded capsule, adds the 0.1-4% micropowder silica gel again and is filled into capsular technical process.
The invention has the advantages that: eliminated residual pesticide and beavy metal impurity by above-mentioned technology, improved pharmaceutical purity greatly, improved every the effective elements of the medicine content, made and once take pharmaceutical quantities and reduce, drug effect but is improved significantly.
Description of drawings
Fig. 1 is preparation technology's flow chart of LIUWEIDIHUANG JIAONANG of the present invention
The specific embodiment
Embodiment 1:
[prescription] Radix Rehmanniae Preparata 1408g Cortex Moutan 528g Rhizoma Dioscoreae 704g
Fructus Corni 704g Rhizoma Alismatis 528g Poria 528g
[method for making] above Six-element is got Poria 110g and is ground into fine powder, and tail over part and decoct with water three times with the residue Poria, each 30 minutes, filter, merging filtrate is concentrated into the thick paste shape; Fructus Corni adds the alcohol reflux secondary, and each 1 hour, filter, medicinal residues are standby; Filtrate recycling ethanol is concentrated into the thick paste shape; The Cortex Moutan steam distillation, and in the distillate of collecting, add the 1mol/L hydrochloric acid solution and make crystallization, filtering, crystallization washes with water, and cold drying is ground into fine powder; Three flavors such as aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and all the other Radix Rehmanniae Preparata decoct with water three times, each 1 hour, filter, merging filtrate by the macroporous adsorptive resins separation and purification, is used 70% ethanol elution, collect eluent, reclaim ethanol, be concentrated into the thick paste shape, add above-mentioned Poria thick paste, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, adds above-mentioned Cortex Moutan extract crystallization fine powder and appropriate amount of auxiliary materials, mixing, incapsulate, make 1000, promptly.
[character] this product is a capsule, and content is that light brown is to brown powder or granule; Bitter in the mouth, little acid.
Every of [assay] this product contains Fructus Corni with ursolic acid (C
30H
48O
3) meter, must not be less than 0.6mg (0.3g/ grain).
[function with cure mainly] enriching yin and nourishing kidney are used for damage of kidney-YIN, dizziness and tinnitus, and soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission is quenched one's thirst.
[usage and consumption] is oral, one time 1 (0.3g/ grain) or one time 2 (0.5g/ grain), one day 2
Inferior.
[storage] sealing
Embodiment 2:
[prescription] Radix Rehmanniae Preparata 1408g Cortex Moutan 528g Rhizoma Dioscoreae 704g
Fructus Corni 704g Rhizoma Alismatis 528g Poria 528g
[method for making] above Six-element is got Poria 350g and is ground into fine powder, and Fructus Corni adds the alcohol reflux secondary, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape; The Cortex Moutan steam distillation, distillate makes crystallization, and is standby; Three flavors such as aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues, residue Poria and all the other Radix Rehmanniae Preparata decoct with water three times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape; Add above-mentioned Poria fine powder and Fructus Corni thick paste, mixing, cold drying is ground into fine powder, adds above-mentioned Cortex Moutan extract and appropriate amount of auxiliary materials, and mixing incapsulates, and makes 2000, promptly.
All the other are every with example 1.
Embodiment 3:
[prescription] Radix Rehmanniae Preparata 1408g Cortex Moutan 528g Rhizoma Dioscoreae 704g
Fructus Corni 704g Rhizoma Alismatis 528g Poria 528g
[method for making] above Six-element is got Poria 110g and is ground into fine powder, and tail over part and decoct with water three times with the residue Poria, each 30 minutes, filter, merging filtrate is concentrated into the thick paste shape; The Fructus Corni ethanol percolation is collected percolate, and medicinal residues are standby; Filtrate recycling ethanol is concentrated into the thick paste shape; The Cortex Moutan steam distillation, and adding 1mol/L hydrochloric acid solution makes crystallization in the distillate of collecting, and filters, crystallization washes with water, and cold drying is ground into fine powder; Three flavors such as aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and all the other Radix Rehmanniae Preparata decoct with water three times, each 1 hour, filter, merging filtrate by the macroporous adsorptive resins separation and purification, is used 70% ethanol elution, collect eluent, reclaim ethanol, be concentrated into the thick paste shape, add above-mentioned Poria thick paste, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, adds above-mentioned Cortex Moutan extract crystallization fine powder and appropriate amount of auxiliary materials, mixing, incapsulate, make 1000, promptly.
All the other are every with example 1.
Claims (7)
1, a kind of new method of LIUWEIDIHUANG JIAONANG preparation, by each medicine treatment process of Six-element, close medicine mixing, drying, be ground into fine powder technology, and mixed powder adds adjuvant filling capsule technology composition, it is characterized in that: in each medicine treatment process, comprise: the Poria with the 1/7-2/3 recipe quantity, be ground into fine powder, the Poria decocting and concentrating of recipe quantity remainder is become the technology of thick paste; Use the solvent processing Fructus Corni, obtain extracting solution, reclaim solvent and the Fructus Corni active component that extracts is condensed into the technology of thick paste; With the Cortex Moutan steam distillation, handle distillate and make crystalline solid through cold drying, be ground into the technology of fine powder; And the medicinal residues after the medicinal residues after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation and Fructus Corni extracted decoct together, its decoction liquor by the macroporous adsorptive resins separation and purification, collect eluent and reclaim ethanol and be condensed into thick paste, or the decoction liquor of the medicinal residues after the medicinal residues after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation and Fructus Corni extracted, directly be condensed into the technology of thick paste.
2, according to the new method of the described LIUWEIDIHUANG JIAONANG of claim 1 preparation, it is characterized in that: describedly obtain extracting solution, be meant the technical process of the ethanol of usefulness 50-95% the Fructus Corni reflux, extract, with the solvent processing Fructus Corni.
3, according to the new method of the described LIUWEIDIHUANG JIAONANG of claim 1 preparation, it is characterized in that: describedly obtain extracting solution, be meant technical process with the alcohol percolation method extraction Fructus Corni percolate of 50-95% with the solvent processing Fructus Corni.
4, the new method for preparing according to the described LIUWEIDIHUANG JIAONANG of claim 1, it is characterized in that: described close medicine mix, dry, be ground into fine powder technology, be meant the Poria fine powder, the thick paste that the Poria decoction liquor of recipe quantity remainder is condensed into, the Fructus Corni extracting solution concentrates thick paste, mixes mutually with the thick paste that medicinal residues after medicinal residues, Fructus Corni after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation extracts decoct the gained decoction liquor jointly, dry, the technical process that is ground into fine powder.
5, the new method for preparing according to the described LIUWEIDIHUANG JIAONANG of claim 1, it is characterized in that: add adjuvant at described mixed powder and load capsular technology, the indication mixed powder is meant the Poria fine powder, the thick paste that the Poria decoction liquor of recipe quantity remainder is condensed into, Fructus Corni extracting solution concentrate thick paste, the fine powder that mixes back drying with thick paste that medicinal residues after medicinal residues, Fructus Corni after Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, the Cortex Moutan distillation extracts decoct the gained decoction liquor jointly, is ground into; It is that this medicated powder is mixed Cortex Moutan extract crystallization fine powder that indication is loaded capsule, adds the starch of 5-50%, the technical process that dextrin incapsulates again.
6, the new method for preparing according to the described LIUWEIDIHUANG JIAONANG of claim 1, it is characterized in that: add adjuvant at described mixed powder and load capsular technology, the indication mixed powder is meant the fine powder that Poria fine powder and each thick paste of having prepared are mixed back drying, are ground into; It is with this fine powder mixing Cortex Moutan extract crystallization fine powder that gained is loaded capsule, adds the dimension crystalline cellulose of 5-30% again, the technical process that incapsulates.
7, the new method for preparing according to the described LIUWEIDIHUANG JIAONANG of claim 1, it is characterized in that: add adjuvant at described mixed powder medicine and load capsular technology, the indication mixed powder is meant the fine powder that Poria fine powder and each thick paste of having prepared are mixed back drying, are ground into; It is that this fine powder is mixed Cortex Moutan extract crystallization fine powder that indication is loaded capsule, adds the 0.1-4% micropowder silica gel again and is filled into capsular technical process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135286 CN1238028C (en) | 2003-06-25 | 2003-06-25 | Method for preparing capsule of six drugs containing rehmannine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135286 CN1238028C (en) | 2003-06-25 | 2003-06-25 | Method for preparing capsule of six drugs containing rehmannine |
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| Publication Number | Publication Date |
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| CN1513514A true CN1513514A (en) | 2004-07-21 |
| CN1238028C CN1238028C (en) | 2006-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 03135286 Expired - Lifetime CN1238028C (en) | 2003-06-25 | 2003-06-25 | Method for preparing capsule of six drugs containing rehmannine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN115137786A (en) * | 2022-07-29 | 2022-10-04 | 吉林省民泰制药股份有限公司 | A capsule containing six ingredients with rehmanniae radix and its preparation method |
-
2003
- 2003-06-25 CN CN 03135286 patent/CN1238028C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN115137786A (en) * | 2022-07-29 | 2022-10-04 | 吉林省民泰制药股份有限公司 | A capsule containing six ingredients with rehmanniae radix and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN1238028C (en) | 2006-01-25 |
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Granted publication date: 20060125 |