CN106389798A - Extraction method for ziziphus jujuba mill.var.spinosa decoction prescription and tuckahoe-cassia twig-atractylodes macrocephala koidz-licorice root decoction prescription - Google Patents
Extraction method for ziziphus jujuba mill.var.spinosa decoction prescription and tuckahoe-cassia twig-atractylodes macrocephala koidz-licorice root decoction prescription Download PDFInfo
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- CN106389798A CN106389798A CN201510456838.6A CN201510456838A CN106389798A CN 106389798 A CN106389798 A CN 106389798A CN 201510456838 A CN201510456838 A CN 201510456838A CN 106389798 A CN106389798 A CN 106389798A
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Abstract
The invention relates to an extraction method for a ziziphus jujuba mill.var.spinosa decoction prescription and a tuckahoe-cassia twig-atractylodes macrocephala koidz-licorice root decoction prescription. The extraction method comprises: (1) respectively carrying out steam distillation on cassia twig and ligusticum chuanxiong hort in the prescription for 1-3 h with a mixture comprising 85-90 wt% of ethanol and 10-15 wt% of water; (b) extracting licorice root in the prescription for 1-3 h with a mixture comprising 10-30 wt% of ethanol and 70-90 wt% of water; (c) respectively extracting herbs excluded in the steps (a)-(b) for 1-3 h with water twice; and (d) merging the extracts in the steps (a)-(c).
Description
Technical field
, with regard to a kind of extracting process of prescription, particularly one kind is with regard to the sweet decoction of suanzaoren decoction and Siberian cocklebur osmanthus for the present invention
The extracting process of side.
Background technology
The history of the existing thousands of years of Chinese medicine development, in Chinese medicine, contained chemical composition is sufficiently complex, has both contained multiple
Effective ingredient, also contains invalid components it is also possible to comprise toxic component.Extract its effective ingredient and add further
With separation, purification, obtain the important content that effective monomer is in Chinese medicine research field.Chinese medicine extraction is exactly
Extract wherein effective ingredient using some technology to greatest extent so that the inherent quality of Chinese medicine preparation and clinical treatment
Effect improves, and so that the effect of Chinese medicine is played to greatest extent, the extraction of Chinese medicine is the important ring of production process
Section, its process, the selection of technological process and device configuration all will be directly connected to quality and the clinic of Chinese medicine
Effect.
According to《Typhoid fever acute disease is discussed》, the usage of general suanzaoren decoction is with eight liters of water (1600cc), boils Semen Ziziphi Spinosae,
Obtain six liters (1200cc), interior all medicines, boil and take three liters (600cc), point temperature three clothes；Typically《The sweet soup in Siberian cocklebur osmanthus》
The use genealogy of law with six liters of water, boil and take three liters, go dregs, point temperature three clothes.
Content of the invention
It is an object of the invention to, provide a kind of extracting process of the sweet decoction side of suanzaoren decoction and Siberian cocklebur osmanthus, to solve
Certainly prior art carries out its own shortcomings that Chinese medicine extraction has：Loss of effective components in Chinese medicine, especially wherein
Non-water-soluble composition；Non-active ingredients can not be to remove to greatest extent, and enrichment factor is not high enough；In extracting solution
In addition to effective ingredient, often impurity is more, still has a small amount of water solublity paste property composition, is often unfavorable for refining；And mistake
A large amount of decomposition of thermal sensitivity effective ingredient can be caused in high-temperature operation.
For solving the above problems, inventors have surprisingly discovered that a kind of extraction of the sweet decoction side of suanzaoren decoction and Siberian cocklebur osmanthus
Method, it comprises the steps of：(a) by the Ramulus Cinnamomi in prescription and Rhizoma Chuanxiong, respectively with 85～90wt% ethanol and 10～
The mixture steam distillation of 15wt% water 1～3 hour；(b) by the Radix Glycyrrhizae in prescription with 10～30wt% ethanol and
The mixture of 70～90wt% water extracts 1～3 hour；C (), by the medical material beyond above-mentioned steps (a)～(b), is distinguished
With water extraction 1～3 hour, it is repeated twice；D above-mentioned steps (a)～(c) extract is merged by ().
In a preferred embodiment, the wherein prescription Semen Ziziphi Spinosae of this suanzaoren decoction, Rhizoma Chuanxiong, the Rhizoma Anemarrhenae, Poria, sweet
Grass.
In another preferred embodiment, the wherein prescription system Poria of this sweet soup in Siberian cocklebur osmanthus, Ramulus Cinnamomi, white, Radix Glycyrrhizae.
In another preferred embodiment, wherein this step (a) is with the mixture steam of 90wt% ethanol and 10wt% water
Distillation 1 hour.
In another preferred embodiment, wherein this step (b) extracts 1 with the mixture of 30wt% ethanol and 70wt% water
Hour.
In another preferred embodiment, it filters after being contained in each (a)～(c) step further.
In another preferred embodiment, it comprises step (e) further by mixture pelleting.
The inventors discovered that, using the extraction of above-mentioned Radix Stephaniae Tetrandrae Radix Astragali soup, GEGEN TANG, guizhi decoction and zhigancao decoction prescription
Take the extract that method is obtained, there is the effective ingredient of high level.
Specific embodiment
The terms " one " or " a kind of " when being used in conjunction in claim or description with "comprising",
May represent has one, but also complies with " one or more " or " at least one ".
The present disclosure generally relates to a kind of extracting process of the sweet decoction side of suanzaoren decoction and Siberian cocklebur osmanthus, it comprises following step
Suddenly：(a) by the Ramulus Cinnamomi in prescription and Rhizoma Chuanxiong, respectively with the mixture of 85～90wt% ethanol and 10～15wt% water
Steam distillation 1～3 hour；B () is by the Radix Glycyrrhizae in prescription with the mixing of 10～30wt% ethanol and 70～90wt% water
Thing extracts 1～3 hour；(c) by the medical material beyond above-mentioned steps (a)～(b), respectively with water extraction 1～3 hour,
It is repeated twice；D above-mentioned steps (a)～(c) extract is merged by ().
From the foregoing, the method for the present invention can be applicable to the sweet decoction side of suanzaoren decoction and Siberian cocklebur osmanthus, in method
Whether the enforcement of each step, depending on the medical material having in each prescription.
For example, it is an aspect of the invention to providing a kind of extracting process of suanzaoren decoction prescription, wherein this prescription
Including but not limited to Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Rhizoma Anemarrhenae, Poria, Radix Glycyrrhizae.
Additionally, when extracting suanzaoren decoction prescription, above-mentioned steps (c) more can be separately added into down according to following symptom
Row prescription, the inclined deficiency of YIN has hot person：Plus the Radix Rehmanniae, Bulbus Lilii, the Radix Paeoniae Alba；Night sweat is notably：Plus Fructus Schisandrae Chinensis, Fructus Tritici Levis；
Palpitation with fear is notably：Plus Os Draconis, Concha Ostreae, Radix Codonopsis；Flaccidity of the limbs due to deficiency of QI is weak：Plus Radix Ginseng, Radix Astragali；Blood deficiency sleeplessness：Sovolin returns,
Radix Rehmanniae Preparata, Radix Polygoni Multiflori；Dysphoria with smothery sensation sleeplessness：Plus Cortex Moutan, Fructus Gardeniae, Herba Lophatheri；Fidgety sleeplessness：Close WEIDANTANG；Frightened
Throb with fear sleeplessness：Close subduing the hyperfunction of the liver to dissipate；Hyperactivity of fire caused by deficiency of YIN：Close Rhizoma Coptidis toxic materials clearing away decoction.
Another aspect of the present invention system with regard to a kind of extracting process of the sweet decoction side in Siberian cocklebur osmanthus, this sweet soup in Siberian cocklebur osmanthus
Prescription is including but not limited to Poria, Ramulus Cinnamomi, white, Radix Glycyrrhizae.
Additionally, when extracting the sweet decoction side in Siberian cocklebur osmanthus, above-mentioned steps (c) can more be separately added into according to following symptom
Following prescription, insufficiency of the spleen, emphysema：Plus Radix Codonopsis, Radix Astragali；Headache, dizzy：Sovolin is returned, Rhizoma Chuanxiong；Vomiting,
Abundant expectoration：Plus the Rhizoma Pinelliae, Pericarpium Citri Reticulatae；Edema：Increase Poria and add Polyporus, Rhizoma Alismatis again；Cardiopalmus are very：Plus Radix Salviae Miltiorrhizae；Cough with asthma：
Plus Herba Ephedrae, Rhizoma Belamcandae, Semen Lepidii (Semen Descurainiae)；Tremble with fear very：Plus Rhizoma Zingiberiss, Radix Aconiti Lateralis Preparata；Leucorrhea：Plus Radix Codonopsis, Concha Ostreae；Deficiency of heart-QI：
Plus Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, the Radix Rehmanniae；Insufficiency of the spleen leading to overabundance of dampness is had loose bowels：Close Pingwei San；Dacryocystisises：Plus Semen Plantaginiss, Rhizoma Coptidis, name
Bright and clear soup.
In above-mentioned extracting process, filter after preferably being further contained in each (a)～(d) step.
In above-mentioned extracting process, preferably can further comprise step (f) by mixture pelleting.
Above-mentioned term " extraction " is to extract wherein effective ingredient to greatest extent so that Chinese medicine using some technology
The inherent quality of preparation and clinical therapeutic efficacy improve, and so that the effect of Chinese medicine is played to greatest extent.Chinese medicine
Extraction be Chinese Traditional Medicine important unit operation, its process, the selection of technological process and equipment are joined
Put and all will be directly connected to quality and the clinical effectiveness of Chinese medicine.
In the present invention, Chinese medicine containing volatile oil, such as Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Zingiberis Recenss, Rhizoma Chuanxiong, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens
Deng, wherein this volatile oil also known as quintessence oil, it is one to there are volatility, the oily liquids that can go out with vapor distillation,
There is fragrance, and this volatile oil is the polytype such as aliphatic compound, aromatic compound note class compound
The mixture of compound, inventors be surprised to learn that this volatile oil Chinese medicine preferably system is extracted to have volatile solution
Take, more preferably but the mixture that is not limited to mix with the ratio of 90wt% ethanol and 10wt% water with ethanol and water
Steam extraction.
In the present invention, containing tcm with glycosides, such as Radix Et Rhizoma Rhei, Cortex Moutan, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Ginseng, Radix Astragali, bavin
Recklessly, SHANGZI, Semen Persicae, Radix Paeoniae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Radix Platycodoniss, Radix Clematidis etc., mostly have colourless, odorless,
Tool bitterness, minority is coloured, minority has the feature of sweet taste, and most in neutral or acid, minority is in alkalescence, big
Most of soluble in water and ethanol, easily generated sugar and aglycon by diluted acid or enzyme hydrolysiss, typically has certain optics and lives
Property, inventors be surprised to learn that the above-mentioned preferably system containing tcm with glycosides is extracted with the mixture of ethanol and water, its ratio is relatively
Good system is with the water of the ethanol mixing 70wt% of 30wt%.
In the present invention, Chinese medicine containing alkaloidss, such as Radix Aconiti Lateralis Preparata, Rhizoma Coptidis, Cortex Phellodendri, Herba Ephedrae, the Rhizoma Pinelliae etc., mostly
Number alkaloids are crystal material, colourless and have optical activity, inventors be surprised to learn that above-mentioned containing in alkaloidss
Medicine preferably system is extracted with the mixture of ethanol and water, and its ratio preferably system is with the water of the ethanol of 70wt% and 30wt%.
In the present invention, Olibanum, Myrrha, Sanguis Draxonis etc., preferably system are extracted 30 minutes with ethanol.
In the present invention, the Chinese medicine such as Os Draconis, Concha Ostreae, preferable system extracts by the way of boiling, the time preferably 2～4
Hour, most preferably 3 hours.
In the present invention, Colla cornus cervi, Colla Corii Asini, Testudiniss angle glue, Borneolum Syntheticum etc., preferably system, without extraction, direct plunge into height
In warm solution, the mixture of the extract of prescription that this pyrosol can extract for other.
In the present invention, Herba Menthae, Herba Asari etc., preferably system, with water extraction 5～15 minutes, are more preferably with water extraction 10
Minute.
Medical material in addition to above-mentioned enumerating in the present invention, preferably system, with water extraction 1 hour, merge after being repeated twice.
If Chinese medicine washes with water before extracting, these powder or particle can be made washed away, adjuvant and effective ingredient
Can be dissolved in water and be washed off so as to curative effect reduces, therefore before Chinese medicine extraction, handy water does not rinse, can only be with cold
Water soaks.The prepared slices of Chinese crude drugs after cold water soak, organizational structure can loose expansion, make effective ingredient easily fried,
Make effective ingredient easily fried.If using hot-water soak at the very start, in medical material, contained protein component will be very
Fast dissolution and freezing film, are wrapped in medical material surface, make moisture be not easy to penetrate in medical material histiocyte,
Effective ingredient also is difficult to decompose out, affects the fried of composition.
Traditional Chinese medicine extraction method includes decocting cooking method, infusion process, percolation, Gelatin improving method, circumfluence method, solvent
Extraction method, steam distillation and sublimed method etc..Solvent extraction method is most widely used method, and it is basis
The property of various effective ingredient dissolubility in Chinese herbal medicine, from molten to other compositions greatly to needing ingredient solubility
The little solvent of Xie Du, a kind of extracting method that required active component is dissolved out in medical material tissue.
Embodiment
Embodiment 1- utilizes the method for the present invention to extract suanzaoren decoction prescription
By taking 15 grams of Semen Ziziphi Spinosae, 3 grams of Rhizoma Chuanxiong, 3 grams of the Rhizoma Anemarrhenae, 5 grams of Poria, 1 gram of Radix Glycyrrhizae in prescription respectively, and according to
According to method of the present invention extraction, with the extracted effective ingredient of weighing method measurement for 6 grams after extraction.
Comparative example 1- utilizes prior art method to extract suanzaoren decoction prescription
By taking 15 grams of Semen Ziziphi Spinosae, 3 grams of Rhizoma Chuanxiong, 3 grams of the Rhizoma Anemarrhenae, 5 grams of Poria, 1 gram of Radix Glycyrrhizae in prescription respectively, and according to
According to known decocting method extraction, will all medical materials in water extraction 2 hours, after extraction, institute is measured with weighing method
The effective ingredient extracting is 4 grams.
Embodiment 2- utilizes the method for the present invention to extract the sweet decoction side in Siberian cocklebur osmanthus
By taking 10 grams of Poria, 7.5 grams of Ramulus Cinnamomi, white 7.5 grams, 5 grams of Radix Glycyrrhizae in prescription respectively, and according to this
Bright method extraction, with the extracted effective ingredient of weighing method measurement for 4.5 grams after extraction.
Comparative example 2- utilizes prior art method to extract the sweet decoction side in Siberian cocklebur osmanthus
By taking 10 grams of Poria, 7.5 grams of Ramulus Cinnamomi, white 7.5 grams, 5 grams of Radix Glycyrrhizae in prescription respectively, and according to known
Decocting method extraction, will all medical materials in water extraction 2 hours, extracted with the measurement of weighing method after extraction
Effective ingredient be 3 grams.
According to above-described embodiment and comparative example result it is seen that using the method for the present invention, compared to prior art
Water-boiling method, more effective ingredient can be extracted, and have preferably effect.
Claims (7)
1. the extracting process of the sweet decoction side of a kind of suanzaoren decoction and Siberian cocklebur osmanthus, it comprises the steps of：
A (), by the Ramulus Cinnamomi in prescription and Rhizoma Chuanxiong, is steamed with the mixture of 85～90wt% ethanol and 10～15wt% water respectively
Steam distillation 1～3 hour；
B Radix Glycyrrhizae in prescription is extracted 1～3 hour by () with the mixture of 10～30wt% ethanol and 70～90wt% water；
C () by the medical material beyond above-mentioned steps (a)～(b), respectively with water extraction 1～3 hour, is repeated twice；
D above-mentioned steps (a)～(c) extract is merged by ().
2. extracting process as claimed in claim 1 it is characterised in that this suanzaoren decoction prescription be Semen Ziziphi Spinosae, Rhizoma Chuanxiong,
The Rhizoma Anemarrhenae, Poria cocos and liquorice.
3. extracting process as claimed in claim 1 it is characterised in that this sweet soup in Siberian cocklebur osmanthus prescription be Poria, Ramulus Cinnamomi,
White and Radix Glycyrrhizae.
4. extracting process as claimed in claim 1 is it is characterised in that this step (a) is with 90wt% ethanol and 10wt% water
Mixture steam distillation 1 hour.
5. extracting process as claimed in claim 1 is it is characterised in that this step (b) is with 30wt% ethanol and 70wt% water
Mixture extract 1 hour.
6. extracting process as claimed in claim 1 is it is characterised in that be contained in mistake after each (a)～(c) step further
Filter.
7. extracting process as claimed in claim 1 is it is characterised in that comprise step (e) further by mixture pelleting.
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| CN201510456838.6A CN106389798A (en) | 2015-07-30 | 2015-07-30 | Extraction method for ziziphus jujuba mill.var.spinosa decoction prescription and tuckahoe-cassia twig-atractylodes macrocephala koidz-licorice root decoction prescription |
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| CN201510456838.6A CN106389798A (en) | 2015-07-30 | 2015-07-30 | Extraction method for ziziphus jujuba mill.var.spinosa decoction prescription and tuckahoe-cassia twig-atractylodes macrocephala koidz-licorice root decoction prescription |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375793A (en) * | 2017-08-16 | 2017-11-24 | 河南科技学院 | A kind of Chinese medicine composition for improving sleep function and preparation method thereof |
| CN108686188A (en) * | 2018-08-06 | 2018-10-23 | 首都医科大学附属北京中医医院 | A kind of Chinese medicine composition for treatment of kidney disease |
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| CN1669571A (en) * | 2004-03-17 | 2005-09-21 | 余世春 | Chinese traditional medicine for treating enteritis and appendicitis, and method for preparing same |
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2015
- 2015-07-30 CN CN201510456838.6A patent/CN106389798A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1669571A (en) * | 2004-03-17 | 2005-09-21 | 余世春 | Chinese traditional medicine for treating enteritis and appendicitis, and method for preparing same |
Non-Patent Citations (2)
| Title |
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| 仝小林: "《仝小林经方新用十六讲》", 30 September 2014, 上海科学技术出版社 * |
| 刘继青: "《中医常用方剂汇编》", 31 May 2014, 厦门大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375793A (en) * | 2017-08-16 | 2017-11-24 | 河南科技学院 | A kind of Chinese medicine composition for improving sleep function and preparation method thereof |
| CN108686188A (en) * | 2018-08-06 | 2018-10-23 | 首都医科大学附属北京中医医院 | A kind of Chinese medicine composition for treatment of kidney disease |
| CN108686188B (en) * | 2018-08-06 | 2021-08-17 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for treating membranous nephropathy |
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