CN107375793A - A kind of Chinese medicine composition for improving sleep function and preparation method thereof - Google Patents
A kind of Chinese medicine composition for improving sleep function and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for improving sleep function and preparation method thereof, belong to the field of Chinese medicines.It is made up of the component of following parts by weight；60 100 parts of ginsengs, 60 100 parts of seed of Oriental arborvitaes, 60 100 parts of spina date seeds, 60 100 parts of Rhizoma Sparganiis, 26 70 parts of sealworts, 26 70 parts of radix scutellariaes, 26 70 parts of Radixs Astragali, 26 70 parts of Radix Codonopsis, 26 70 parts of moxibustion radix glycyrrhizaes, 26 70 portions of matrimony vines, 20 60 portions of root of herbaceous peonys, 20 60 parts of donkey-hide gelatin, 20 60 parts of hen egg yolks, 10 30 parts of Poria cocos, present invention also offers the preparation method of above-mentioned Chinese medicine composition.The Chinese medicine composition soothing the liver qi-regulating of the present invention, moistens the lung and nourish yin, strengthening QI of middle-JIAO, clearing away the heart fire and tranquillizing, and sealwort assistant make it that the benefiting action of ginseng is preferably shown with Poria cocos, and and can Yin-nourishing and body fluid promoting, unlikely help is superfluous, damp and hot interior stagnant, and negative and positive are minored, and vital essence is simultaneously mended.
Description
Technical field
The present invention relates to traditional Chinese medical science field, and in particular to a kind of Chinese medicine composition for improving sleep function and preparation method thereof.
Background technology
Sleep is a kind of important physiological phenomenon in our daily lifes, and 1/3 time of life is spent in sleep,
Sleep not only has close relationship with the physiology and psychological activity of people, and has vital influence to the health of people,
Good sleep can make one dispelling fatigue, regain one's strength and spirit；Good waking state is kept, work is improved and is imitated with study
Rate, extend the life-span；Shown according to investigation, many people are suffering from obstacle or the disease related to sleep in terms of sleep, grow up
People occurs that the ratio of sleep-disorder is up to 30%, and most common insomnia is one kind of sleep-disorder, and many people at fault dormancy
Experience, also experienced the pain of insomnia, the insomnia of short time can cause the sense of fatigue of people, uneasiness, general malaise, it is listless,
Delay of response, headache, memory are not concentrated, and then are occurred surprisingly when being engaged in high-risk professional, or even threat to life.And long-term
Insomnia harm is bigger, and chronic insomnia can accelerate the aging of skin, causes hypertension, induces the mood such as neurasthenia, depression and anxiety
Problem.
With the development of society, increasingly fierce social competition makes the psychological pressure of people increasing, sleep insufficiency and
Sleep-disorder turns into the big illness for having a strong impact on that people are physically and mentally healthy.What is clinically used at present has syngignoscism
Chemical synthetic drug, because there is serious toxic side effect, its application receives certain limitation.Because the traditional Chinese medical science has uniqueness to improving sleep
Theory, have the characteristics of uniqueness in treatment insomnia, Chinese medicine less toxic side effect again, therefore, at present people it is positive in
Basic theories is cured to instruct, the medicine with syngignoscism is found and developed from Chinese medicine tradition prescription.The traditional Chinese medical science thinks, meeting of staying up late
Cause it is fire excess from yin deficiency, so the traditional Chinese medical science is said and fire excess from yin deficiency is apt to occur in " night owl " that often stays up late and elderly population.Type of hyperactivity of fire caused by deficiency of YIN
Insomniac, except have difficulty in going to sleep after going to bed, early awakening or middle interruption wakes up or dreaminess bad dreams, seemingly sleep non-sleep or difficult all night
Outside the cardinal symptoms such as dormancy, vexed, palpitaition, the heating of brothers' heart, night sweat, thirsty, dry throat, the erosion of mucous membrane in the oral cavity, tongue are had concurrently simultaneously toward contact
Matter is red, few tongue, pulse condition are counted accurately etc. is commonly called as the symptom got angry.And " fire " that this makes troubl, it is clear not but to be that drinks merely herbal tea
" excess fire " that heat can just solve, but " fire of deficiency type " described in the traditional Chinese medical science.The internal organs that type of hyperactivity of fire caused by deficiency of YIN insomnia is involved are mainly the heart and kidney.
Traditional Chinese medical science five-elements theory thinks, the heart matches fire, kidney category water, water can fire processed, under physiological conditions, kidney Ji internal heat waterborne, make internal heat unlikely
In partially prosperous and upset the mind.Often stay up late, old kidney qi degradation etc., cause kidney water deficiency high will to be contained with fire processed, internal heat,
Upset the mind, kidney-yin deficiency and internal heat is prosperous, negative and positive are not mutually harmonious, thus have a sleepless night.It can be seen that this type of insomnia, total pathomechanism
It is asthenic yin and sun is had a surplus.
The content of the invention
The invention aims to overcome the problems of the prior art, there is provided a kind of Chinese traditional medicine composition for improving sleep function
Thing and preparation method thereof.
The invention provides a kind of Chinese medicine composition for improving sleep function, it is made up of the component of following parts by weight：60-
100 parts of ginsengs, 60-100 parts seed of Oriental arborvitae, 60-100 parts spina date seed, 60-100 parts Rhizoma Sparganii, 26-70 parts sealwort, 26-70 parts radix scutellariae,
26-70 parts Radix Astragali, 26-70 parts Radix Codonopsis, 26-70 part moxibustions radix glycyrrhizae, 26-70 parts matrimony vine, 20-60 parts root of herbaceous peony, 20-60 parts donkey-hide gelatin, 20-
60 parts of hen egg yolks, 10-30 part Poria cocos.
It is preferred that a kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight：75-95 parts
Ginseng, 75-95 parts seed of Oriental arborvitae, 75-95 parts spina date seed, 75-95 parts Rhizoma Sparganii, 30-60 parts sealwort, 30-60 parts radix scutellariae, 30-60 parts
The Radix Astragali, 30-60 parts Radix Codonopsis, 30-60 part moxibustions radix glycyrrhizae, 30-60 parts matrimony vine, 15-45 parts root of herbaceous peony, 15-45 parts donkey-hide gelatin, 15-45 part chickens
Sub yellow, 5-25 part Poria cocos.
It is preferred that a kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight：95 parts of people
Ginseng, 80 parts of seed of Oriental arborvitaes, 80 parts of spina date seeds, 80 parts of Rhizoma Sparganiis, 45 parts of sealworts, 45 parts of radix scutellariaes, 40 parts of Radixs Astragali, 40 parts of Radix Codonopsis, 55 parts of moxibustions
Radix glycyrrhizae, 45 portions of matrimony vines, 30 portions of root of herbaceous peonys, 33 parts of donkey-hide gelatin, 33 parts of hen egg yolks, 15 parts of Poria cocos.
A kind of it is preferred that Chinese medicine composition for improving sleep function, it is characterised in that：It is made according to Chinese patent drug routine techniques
Tablet, pill, powder, electuary or capsule.
It is specific as follows present invention also offers a kind of preparation method for the Chinese medicine composition for improving sleep function：
Step 1, each component is weighed by above-mentioned parts by weight；
Step 2, by the seed of Oriental arborvitae weighed, spina date seed, Rhizoma Sparganii, sealwort, radix scutellariae, the Radix Astragali, Radix Codonopsis, moxibustion radix glycyrrhizae, matrimony vine, chicken
Yellow, Poria cocos shreds respectively, mixes, obtains medicinal mixture, adds cold water to divide to 2-3 centimetres of medicinal mixture, immersion 20-30 is not crossed
Clock, then use slow fire instead after ebuillition of heated with high heat and decoct 40-60 minutes slowly, it need to stir 2-5 times when boiling medicine, be received with antiseptic gauze filter residue
Collect decoction；
Step 3, ginseng is weighed, divides pot separately to decoct, adding cold water, intense fire boils after cold soaking 20-30 minutes to 2-3 centimetres of ginseng is not crossed
Boiling, slow fire decocts 60-120 minutes slowly, with antiseptic gauze residue collection decoction；
Step 4：Donkey-hide gelatin will be added after step 2 and step 3 gained decoction quickly mixing, continuously stirred 15 minutes, to donkey-hide gelatin
It is completely dissolved into decoction, obtains improving the Traditional Chinese medicine composition liquid medicine of sleep.
Present invention also offers above-mentioned Chinese medicine composition to prepare the application in improving sleep medicine.
Compared with prior art, a kind of beneficial effect for the Chinese medicine composition for improving sleep function of the present invention is：The present invention
Chinese medicine composition based on the Chinese medicine that is easy to get, raw material resources are wide, and safe without toxic side effect, compatibility is reasonable, quick, treat
Effect is definite, and the present invention focuses on tranquilizing mind using ginseng, the seed of Oriental arborvitae, spina date seed, Rhizoma Sparganii as monarch drug in a prescription, and nourishing heart gas, profit kidney is dry, soothing the liver reason
Gas, moisten the lung and nourish yin, using radix scutellariae, the Radix Astragali, Radix Codonopsis, moxibustion radix glycyrrhizae as ministerial drug, focus on strengthening QI of middle-JIAO, build up health, with the root of herbaceous peony, donkey-hide gelatin,
Hen egg yolk focuses on enriching yin, the effect of playing clearing away the heart fire and tranquillizing, and it is preferably aobvious that sealwort assistant with Poria cocos make it that the benefiting action of ginseng is able to
It is existing, while and can Yin-nourishing and body fluid promoting, clearing damp and promoting diuresis, unlikely help is superfluous, damp and hot interior stagnant, and negative and positive are minored, and vital essence is simultaneously mended, the moon of the five internal organs
Positive vital essence is able to good rehabilitation, improves and is become estranged caused sleeping problems by negative and positive.
Embodiment
The embodiment of the present invention is described in detail below, it is to be understood that protection scope of the present invention is not
Limited by embodiment.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creativeness
The every other embodiment obtained on the premise of work, belongs to the scope of protection of the invention.
A kind of Chinese medicine composition for improving sleep function provided by the invention, is made up of the component of following parts by weight：60-
100 parts of ginsengs, 60-100 parts seed of Oriental arborvitae, 60-100 parts spina date seed, 60-100 parts Rhizoma Sparganii, 26-70 parts sealwort, 26-70 parts are yellow
A kind of reed mentioned in ancient books, 26-70 parts Radix Astragali, 26-70 parts Radix Codonopsis, 26-70 part moxibustions radix glycyrrhizae, 26-70 parts matrimony vine, 20-60 parts root of herbaceous peony, 20-60 parts donkey-hide gelatin,
20-60 parts hen egg yolk, 10-30 part Poria cocos.
Said components have the effect of following and effect respectively：
1st, ginseng：Ginseng is one of Relict Plant ancient on the earth, is the rare medicinal herbs that well-known, old children all knows,
It is known as " kings of hundred grass ".In medical book very early《Sheng Nong's herbal classic》In be considered as, ginseng has " tonifying five zang organs, soothe the nerves, fixed
The effect of soul, stop palpitate with fear, remove pathogenic factor, happy intelligence development of improving eyesight ", " long term usage make light of one's life by commiting suicide macrobiosis ".Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》In
Ginseng is extremely praised highly, it is believed that it can " control male woman all chronic diseases marked by deficiency of vital energy ".For thousands of years, ginseng is all listed in " top grade " in Chinese herbal medicine；
《The empty member mirror of reason》In once said：" ginseng can reinforce vital energy, in cloudy tonifying yin, in positive yang-tonifying, can Wen Nengqing, the vital organs of the human body, nothing can be entered
Through less than, invigorating heart gas, tranquilizing mind "；Detected by modern biotechnology Medical Technologist, ginsenoside, panaxan, ginseng in ginseng
The compositions such as albumen all have an impact to nervous system, cardiovascular system, immune system, by nourishing conditioning physical function comprehensively.
2nd, the seed of Oriental arborvitae：《Sheng Nong's herbal classic》：" cypress is real, sweet taste, main palpitation with fear, five viscera settling, QI invigorating, curing rheumatism numbness, long term usage order
People moistens, beauty, normal hearing and eyesight.《Compendium of Materia Medica》：" nourishing heart gas, profit kidney is dry, and peace soul determines soul, and intelligence development is allayed excitement." " seed of Oriental arborvitae is mild-natured
It is sweet and mends without cold not dry, it is pungent and can moisten, its gas delicate fragrance, the saturating heart kidney of energy, Energy benefit taste.
3rd, spina date seed:《Do not record》：Master is vexatious to sleep, and pain, blood turn to let out long navel up and down, abnormal sweating polydipsia, bowl spares, beneficial irritability,
Hard muscles and bones, cloudy gas is helped, make us fertile strong.《Bencao Shiyi》：Sleeping more lifes makes, and must not sleep and fry.Wang Haogu：Milk-livered egersis is controlled, is trembled with fear,
Fry clothes；Somnolence due to gallbladder-excess is controlled, heat is raw to use.《Collected statements on the herbal foundation》：Hold back gas to calm the nerves, flourish muscle supports marrow, and stomach fortune spleen.《Book on Chinese herbal medicine is new again》：It is flat
Liver and qi, moisten the lung and nourish yin, middle benefit gas dampness removing, hold back gas hidroschesis, beneficial will is breathed out surely, hearing-improing and eyesight improving.
4th, Rhizoma Sparganii：Blood-breaking, Xiao Ji Zhi Tong.Hemostasia and promoting granulation, relieving palpitation improving eyesight；《Compendium of Materia Medica》:Logical Liver Channel hematocele；《This
Through meeting original》:Black taro is kind, and to ruin copper be that the heavily fortified point that disappears cuts the thing of product, take borax people it is suitable it.Control that wine visitor's lung stomach is damp and hot, and sound is unclear, and abdomen again
Middle heat product disease due to noxious agents produced by various parasites.
5th, sealwort：《This is through meeting original》：Sealwort, wide middle QI invigorating, five Tibetan are made to reconcile, muscle sufficiency, marrow is hard by force, is all tonifying yin
Work(；《Book on Chinese herbal medicine is just read》：Sealwort, to grow greasy product, long term usage makes us not hungry, if insufficiency of the spleen have wet person, should not take it, probably its greasy diaphragm
.This flavour of a drug is sweet as maltosemalt sugar, mild-natured matter profit are modern for the certified products of nourished spleen Yin《Chinese Pharmacopoeia》Record, its property is sweet, flat, has and mends
Gas yin-nourishing, invigorating the spleen, moistening lung, kidney-nourishing effect, available for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, asthenia of essence and blood,
Waist urushic acid is soft, Heat Diabetes, then compatibility radix polygonati officinalis, and this taste property of medicine sweet taste, soft and moist more liquid, enter lung channel energy lung-yin nourishing and moistening lung stops
Cough, enter stomach energy nourishing stomach-YIN and promote the production of body fluid to quench thirst.
6th, the Radix Astragali：《Book on Chinese herbal medicine meets original》Carry " all void of Radix Astragali energy tonifying five zang organs, controls veins string spontaneous perspiration, rushes down yin fire, removes lung heat, it is lossless then
Hair, has sweat then to stop "
7th, radix scutellariae：《This is through meeting original》：Former times people is reduced phlegm and internal heat not as good as radix scutellariae, the special main few positive alternative fever and chill of lid radix bupleuri, few sun with radix bupleuri
For pivot, non-radix bupleuri can not declare logical China and foreign countries；The radix scutellariae specially main bright steaming of sun, YANG MING being in the center, non-radix scutellariae, which can not be opened to let out, accumulates work, a main wind wood
It is objective evil, accumulate work on a master is wet, Ju can mix opinion.Though a kind of reed mentioned in ancient books bitter cold, the medicine to take stopgap measures after all, only the hot person of the body preferably it, it is empty if deficiency of Yin latent heat
Sun becomes visible, and can gently try its real person and row chong channel, controls blood-heat bleeding, ancient prescription has sub- a kind of reed mentioned in ancient books ball simply, controls woman's blood-head, sudden and violent through water
More than person down, most imitates.
8th, Radix Codonopsis：《Herbal justice》：Radix Codonopsis power energy tonifying spleen nourishing the stomach, moistening lung and production of body fluid, gas during tendon is transported, sheet and ginseng not very phase
Far.Its outstanding valuable person, then invigorating the spleen fortune is without dry, and for taste stomach-Yin without wet, moistening lung is cold and cool without violating, and blood-nourishing is greasy without growing partially, inspires
Clear sun, gas in vibration, and without just dry disadvantage.And it is thick and heavy than the strength of distant ginseng, and it is relatively cloudy soft less, and the smell of Korean ginseng is male
It is strong, and it is micro- dislike in fiery and forthright person, must particularly neutralize just, suitable the five internal organs are handed over is supported by it, and without toward should not.
9th, moxibustion radix glycyrrhizae：Tonifying spleen and stomach, Yiqi and vein recovery.It is weakness of the spleen and the stomach, lassitude hypodynamia, severe palpilation, intermittent pulse.
10th, matrimony vine：《Sheng Nong's herbal classic》Record：" the hard muscles and bones of matrimony vine long term usage energy, resistance to cold and heat, make light of one's life by commiting suicide not old, be it in Chinese medicine
Top grade.”《Compendium of Materia Medica》" fruit of Chinese wolfberry is sweet flat and moistens, the kidney tonifying of property nourishing ... energy, moistening lung, production of sperm, QI invigorating, and this is flat benefit for record
Medicine.
11st, the root of herbaceous peony：《Haigoushen》：" lung perverse trend is controlled, Fu Zhong Xu pains, vim and vigour accumulation is logical to declare internal organs to gather around gas, controls evil pain sepsis,
Disease bone heat, strong the five internal organs, kidney tonifying gas when main, it is swollen to control trusted subordinate's heavily fortified point, and married woman's blood closes obstructed, dispersing blood stasis blood, can lose purulence,《Medicine origin》：" peace
The spleen channel, stomachache is controlled, receive stomach Qi, antidiarrheal profit, and blood, fixing striae, purging the liver of pathogenic fire, tonifying spleen and stomach.
12nd, donkey-hide gelatin：Enrich blood enriching yin, moisturize, stop blooding.For blood deficiency chlorosis, dizziness palpitaition, dysphoria and insomnia, xeropulmonary cough.
13rd, Ji Huangzi：.《Chinese animal drugs》：" nourishing Yin and moistening dryness, nourishing blood for calming endogenous wind, desinsection removing toxic substances.Dysphoria and insomnia is controlled, consumptive disease is told
Blood, hepatitis, indigestion, diarrhoea, anal fistula etc.；《Compendium of Materia Medica》：" tonifying yin blood, relieving heat toxin, control the inferior dysentery "；《Book on Chinese herbal medicine is new again》：" mend
Middle QI invigorating, kidney benefit the moon is supported, is moistened the lung and relieve the cough, can be handed over heart kidney, lung kidney can be taught also.Viscerasthenia hemoptysis, it is active here ".
14th, Poria cocos：《Bencao Jingshu》：" Poria cocos, its sweet taste, property is then nontoxic, enters the few the moon of brothers, the big sun of hand, foot is lunar,
Yangming Channel, the YIN aspect of YANG.Chest side of body is evil in the few the moon of hand against gas；Sorrow angers frightened heresy, all deficiency of heart-QI；Probably do not throb with fear person, kidney will deficiency
；Pain is tied under the heart, fever and chills dysphoria, cough is inverse, and mouth Jiao's tongue is done, and also hand is few cloudy by heresy.It is sweet can bowl spares, light and sharp key, the bowl spares then heart
Spleen is real, sharp key then heat symptoms caused by an exopathgen solution, and heart spleen sorrow actually is angerd frightened evil from only, and heat symptoms caused by an exopathgen solution then knot pain, fever and chills dysphoria under the heart, cough is inverse, the burnt tongue of mouth
Dry middle burnt by damp and hot, then mouth hair is thirsty from removing, and wet in spleen, temper is weak, likes to sleep, and big abdomen person, spleen soil void is unable to Li Shui, therefore abdominal distension is big
.Drip person is drenched, spleen is by damp evil, then disturbance in water passage.Caused by phlegm water oedema in diaphragm, all edge are insufficiency of the spleen, middle burnt person, spleen soil is controlled
, dysfunction of middle-JIAO, therefore see this disease, Li Shui reality spleens, then it is demonstrate,proved moves back certainly.Chest internal organs is opened, visceral-qi is adjusted, cuts down kidney heresy person, He Mofeili water
Dehumidifying, the work(of antipyretic dissipating bind.White person enters qi leel, and red person enters blood system, bushing benefit spleen, in vain better than red, tonneau small intestine, specially dehumidifying
Heat, red also victory are white.”
Preferably, the present invention provides a kind of Chinese medicine composition for improving sleep, including following examples：
Embodiment 1
A kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight；60 parts of ginsengs, 60 portions of cypresses
Sub- benevolence, 60 parts of spina date seeds, 60 parts of Rhizoma Sparganiis, 26 parts of sealworts, 26 parts of radix scutellariaes, 26 parts of Radixs Astragali, 26 parts of Radix Codonopsis, 26 parts of moxibustion radix glycyrrhizaes, 26 parts
Matrimony vine, 20 portions of root of herbaceous peonys, 20 parts of donkey-hide gelatin, 20 parts of hen egg yolks, 10 parts of Poria cocos.
Preparation method is：
Step 1, each component is weighed by following parts by weight：60 parts of seed of Oriental arborvitaes, 60 parts of spina date seeds, 60 parts of Rhizoma Sparganiis, 26 parts of Huangs
Essence, 26 parts of radix scutellariaes, 26 parts of Radixs Astragali, 26 parts of Radix Codonopsis, 26 parts of moxibustion radix glycyrrhizaes, 26 portions of matrimony vines, 20 portions of root of herbaceous peonys, 20 parts of hen egg yolks, 10 parts of Fu
Siberian cocklebur；
Step 2, by the seed of Oriental arborvitae weighed, spina date seed, Rhizoma Sparganii, sealwort, radix scutellariae, the Radix Astragali, Radix Codonopsis, moxibustion radix glycyrrhizae, matrimony vine, chicken
Yellow, Poria cocos shreds respectively, mixes, obtains medicinal mixture, adds cold water to divide to 2-3 centimetres of medicinal mixture, immersion 20-30 is not crossed
Clock, then use slow fire instead after ebuillition of heated with high heat and decoct 40-60 minutes slowly, it need to stir 2-5 times when boiling medicine, be received with antiseptic gauze filter residue
Collect decoction；
Step 3,60 parts of ginsengs are weighed, divide pot separately to decoct, add cold water to no 2-3 centimetres of ginseng of mistake, it is military after cold soaking 20-30 minutes
Fire is boiled, and slow fire is decocted 60 minutes slowly, with antiseptic gauze residue collection decoction；
Step 4：Step 2 and step 3 gained decoction are quickly added into 20 parts of donkey-hide gelatin after mixing, continuously stir 15 minutes, extremely
Donkey-hide gelatin is completely dissolved into decoction, obtains improving the Traditional Chinese medicine composition liquid medicine of sleep, each taking 100ml, three times per day.
Embodiment 2
A kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight：100 parts of ginsengs, 100 parts
The seed of Oriental arborvitae, 100 parts of spina date seeds, 100 parts of Rhizoma Sparganiis, 70 parts of sealworts, 70 parts of radix scutellariaes, 70 parts of Radixs Astragali, 70 parts of Radix Codonopsis, 70 parts of moxibustion radix glycyrrhizaes,
70 portions of matrimony vines, 60 portions of root of herbaceous peonys, 60 parts of donkey-hide gelatin, 60 parts of hen egg yolks, 10-30 part Poria cocos.
Step 1, each component is weighed by following parts by weight：100 parts of seed of Oriental arborvitaes, 100 parts of spina date seeds, 100 parts of Rhizoma Sparganiis, 70 parts
Sealwort, 70 parts of radix scutellariaes, 70 parts of Radixs Astragali, 70 parts of Radix Codonopsis, 70 parts of moxibustion radix glycyrrhizaes, 70 portions of matrimony vines, 60 portions of root of herbaceous peonys, 60 parts of hen egg yolks, 10-30
Part Poria cocos；
Step 2, by the seed of Oriental arborvitae weighed, spina date seed, Rhizoma Sparganii, sealwort, radix scutellariae, the Radix Astragali, Radix Codonopsis, moxibustion radix glycyrrhizae, matrimony vine, chicken
Yellow, Poria cocos shreds respectively, mixes, obtains medicinal mixture, adds cold water to divide to 2-3 centimetres of medicinal mixture, immersion 20-30 is not crossed
Clock, then use slow fire instead after ebuillition of heated with high heat and decoct 40-60 minutes slowly, it need to stir 2-5 times when boiling medicine, be received with antiseptic gauze filter residue
Collect decoction；
Step 3,100 parts of ginsengs are weighed, divide pot separately to decoct, add cold water to do not cross 2-3 centimetres of ginseng, after cold soaking 20-30 minutes
Boil by intense fire, slow fire is decocted 120 minutes slowly, with antiseptic gauze residue collection decoction；
Step 4：Step 2 and step 3 gained decoction are quickly added into 60 parts of donkey-hide gelatin after mixing, continuously stir 15 minutes, extremely
Donkey-hide gelatin is completely dissolved into decoction, is concentrated and dried, tablet, pill, powder, electuary or glue is made according to Chinese patent drug routine techniques
Capsule is taken, each taking 10-15mg, 2 times a day.
Embodiment 3
A kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight：75 parts of ginsengs, 75 portions of cypresses
Sub- benevolence, 75 parts of spina date seeds, 75 parts of Rhizoma Sparganiis, 30 parts of sealworts, 30 parts of radix scutellariaes, 30 parts of Radixs Astragali, 30 parts of Radix Codonopsis, 30 parts of moxibustion radix glycyrrhizaes, 30 parts
Matrimony vine, 15 portions of root of herbaceous peonys, 15 parts of donkey-hide gelatin, 15 parts of hen egg yolks, 5 parts of Poria cocos；
Embodiment 4
A kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight：95 parts of ginsengs, 95 portions of cypresses
Sub- benevolence, 95 parts of spina date seeds, 95 parts of Rhizoma Sparganiis, 60 parts of sealworts, 60 parts of radix scutellariaes, 60 parts of Radixs Astragali, 60 parts of Radix Codonopsis, 60 parts of moxibustion radix glycyrrhizaes, 60 parts
Matrimony vine, 45 portions of root of herbaceous peonys, 45 parts of donkey-hide gelatin, 45 parts of hen egg yolks, 25 parts of Poria cocos；
Embodiment 5
A kind of Chinese medicine composition for improving sleep function, is made up of the component of following parts by weight：95 parts of ginsengs, 80 portions of cypresses
Sub- benevolence, 80 parts of spina date seeds, 80 parts of Rhizoma Sparganiis, 45 parts of sealworts, 45 parts of radix scutellariaes, 40 parts of Radixs Astragali, 40 parts of Radix Codonopsis, 55 parts of moxibustion radix glycyrrhizaes, 45 parts
Matrimony vine, 30 portions of root of herbaceous peonys, 33 parts of donkey-hide gelatin, 33 parts of hen egg yolks, 15 parts of Poria cocos.
Some Clinic Cases are set forth below and by taking the formula of embodiment 1 as an example, illustrate the effect of medicine of the invention itself.
First, clinical trial
1st, the particle prepared with embodiment 1 is carried out clinical trial and treats sleep-disorder patient 100, male 50, female 50,
Twice daily, every time one bag, one bag of 15mg, continuously take 30 days.
2nd, evaluation criteria：
Clinical recovery：The length of one's sleep recovers normal, or Nighttime sleep, more than 6 hours, sleep is deep, energy after waking up
Plentifully.
Significant effect：Sleep is clearly better, and the length of one's sleep increases by more than 3 hours, Depth of sleep increase.
Effect is general：Symptom mitigation, the length of one's sleep increased less than 3 hours earlier above.
It is invalid：Above-mentioned standard is not reached.
3rd, treatment results
As a result show, the pharmaceutical composition of embodiment 1 has the effect for the sleep that improves significantly, to male patient's effect more
It is good.
2nd, zoopery
1 experiment purpose
To the Traditional Chinese medicine composition formula of embodiment 1, powder is conventionally made, and its acute toxicity is made and commented
Valency, experimental basis is provided for data for clinical drug use.
2 experiment materials
2.1 test medicine：The Traditional Chinese medicine composition formula of embodiment 1 conventionally manufactured powder.Usage and dosage：
Orally, be grown up each 15g, 2 times a day.(pressing 70kg batheroom scales) day dosage of being grown up is 0.43g/kg.
2.2 experimental animal：Zoopery is male ICR mouse for examination mouse, is provided by medicine inspecting institute of Jiangsu Province.
2.3 pretreatment：Mouse after 3d chow diets feed adaptation, tested by packet.It is small to choose 200 male ICR
Mouse, body weight are (22 ± 2) g.5 experimental groups are randomly divided into, every group is 40 mouse.Each experimental group sets 3 different dosings
Dosage, its dosage are respectively 120,450 and 1000mg/kg, and it is negative control group to concurrently set distilled water.Experiment carries out 30d,
The measure of indices was carried out after the 10th day, the 20th day and the 30th day respectively.
3 experimental methods：
The measure of 3.1 maximum dosage-feedings：Press mass of object point 4 groups of (low dose group, middle dose group, high dose groups at random
And control group), every group 10.After fasting 16h, mouse stomach gives tested material biggest quality concentration 0.6g/mL and maximum gavage
It is administered volume 40mL/kg, daily gastric infusion 2 times, is spaced 6h.Blank group gavage equivalent distilled water.Continuously seen in 4h after administration
Examine, respectively observation 1 time of daily morning and afternoon, Continuous Observation 30d.Observe animal body quality and the state of mind and record symptom in detail goes out
Existing, recovery and death time.Weight determines：Determined 1 time every 10d when buying day, animal packet, after administration, animal is cutd open
Determined 1 time during inspection.Whole off-test next day animal dislocation is put to death, and is dissected.To animal appearance, each internal organs of whole body during cut open inspection
Visually observed, make histopathological examination if noting abnormalities.
3.2 improve the evaluation of sleep health function
3.2.1 direct sleep experiments continuous gavage mouse 30d, per 10d, once, the sleep of observation each group mouse occurs for observation
Rate.Sleep using righting reflex loss as judge index, when mouse is placed in dorsal position, in 60s can not the person of righting, that is, think to right
Areflexia, into sleep.
3.2.2 extend yellow Jackets length of one's sleep experiment continuous gavage mouse 30d, a last is observed per 10d to sample
Or after distilled water 15min, each group mouse peritoneal injection 50mg/kg yellow Jackets, injection volume 0.2ml/20g, to right instead
It is index to penetrate disappearance, observes the length of one's sleep.
3.2.3 pentobarbital sodium sub-threshold lull dosage experiment continuous gavage mouse 30d, a last is observed per 10d to sample
Or after distilled water 15min, each group mouse peritoneal injection 30mg/kg yellow Jackets maximum subthreshold hypnotic dosages, injection volume is
Sleep (righting reflex loss 1min above persons) number of mice in 0.2ml/20g, observation 30min.
3.2.4 yellow Jackets Sleep latency experiment continuous gavage mouse 30d, observed per 10d a last to sample or
After distilled water 20min, each group mouse peritoneal injection 250mg/kg yellow Jackets, injection volume 0.2ml/20g, with righting reflex
Disappear for index, observation Sleep latency.
3.2.4 data processing and statistical data analysis carry out variance analysis with SPSS13.0 softwares, determine significant difference
Property.
4 results
4.1 from the administration same day until off-test, and mouse is in good condition, and activity and diet are acted normally, and hair frontlighting
It is bright, formed stools, do not occur animal dead situation, also do not observe obvious abnormal response situation.
It is 48g/kg to calculate and always give dose in 24 hours, and adult's (pressing 70kg batheroom scales) clinical day dosage is 30g/
70kg (i.e. 0.43g/kg), the multiple (multiple=48/0.43=111 times) extrapolated equivalent to clinical day dosage are more than
100 times, show that the Chinese medicine composition toxicity is relatively low, safe range is big.
Influence to the weight of animals, each group animal is before experiment to during off-test, not showing difference trend (P ＞
0.05), each animal subject weight is in a certain degree of growth, does not influence animal subject after illustrating the tested material gastric infusion
Growth, the results are shown in Table 1.
Table 1 improve sleep 1 group of mouse weight influence (N=10)
4.2 direct sleep experiments
Influence of the table 2 to the direct sleep of mouse
From table 2, administration 10 days, 20 days, 30 days respectively after last dose, observe the activity feelings of mouse in 60min
Condition, each dosage group and control group during this period, mouse occurs without sleep phenomenon after oral gavage.
4.3 extend the mouse sleep time experiment of yellow Jackets induction
The influence for the mouse sleep time that table 3 is induced yellow Jackets
From table 3, respectively observation administration 10 days, 20 days, after 30 days last dose 15min mouse the length of one's sleep, respectively
Dosage group has obvious extension trend compared with control group, to the mouse sleep time of yellow Jackets induction, is examined through statistics
Test, middle dose group has conspicuousness (P ＜ 0.05) with control group comparing difference
4.4 yellow Jackets sub-threshold dose hypnosis are tested
Table 4 has an impact to sub-threshold dose yellow Jackets inducing mouse sleep incidence
As shown in Table 4, middle dosage and high dose group can substantially increase sleep rate of the mouse in 30min, with control group
Contrast difference is notable (P ＜ 0.05), and low dose group is not notable (P ＞ 0.05) with control group contrast difference；
4.5 yellow Jackets Sleep latencies are tested
The influence of the yellow Jackets Sleep latency of table 5
As shown in Table 5, middle dose group and control group contrast difference are notable (P ＜ 0.05), and low dose group and high dose group
It is not notable (P ＞ 0.05) with control group contrast difference.
In summary, each dosage group of pharmaceutical composition in embodiment 1 is eaten without obvious direct syngignoscism according to health care
Product method of determination and evaluation, it was demonstrated that the pharmaceutical composition of the present embodiment 1 is respectively provided with the effect for improving sleep, and wherein middle dose group improves
The best results of sleep.
It should be noted that when being related to number range in claims of the present invention, it is thus understood that each number range
Any one numerical value can be selected between two end points and two end points, because the step method of use is identical with embodiment,
In order to prevent repeating, description of the invention preferred embodiment, because embodiment 1-5 effect is similar, the present invention only describes
The effect of embodiment 1.Although an embodiment of the present invention has been shown and described, for one of ordinary skill in the art and
Speech, it is possible to understand that these embodiments can be carried out with a variety of changes without departing from the principles and spirit of the present invention, repaiied
Change, replace and modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of Chinese medicine composition for improving sleep function, it is characterised in that be made up of the component of following parts by weight：60-100
Part ginseng, 60-100 parts seed of Oriental arborvitae, 60-100 parts spina date seed, 60-100 parts Rhizoma Sparganii, 26-70 parts sealwort, 26-70 parts radix scutellariae, 26-
70 parts of Radixs Astragali, 26-70 parts Radix Codonopsis, 26-70 part moxibustions radix glycyrrhizae, 26-70 parts matrimony vine, 20-60 parts root of herbaceous peony, 20-60 parts donkey-hide gelatin, 20-60
Part hen egg yolk, 10-30 part Poria cocos.
2. a kind of Chinese medicine composition for improving sleep function as claimed in claim 1, it is characterised in that by following parts by weight
Component be made：75-95 part ginsengs, 75-95 parts seed of Oriental arborvitae, 75-95 parts spina date seed, 75-95 parts Rhizoma Sparganii, 30-60 parts sealwort,
30-60 parts radix scutellariae, 30-60 parts Radix Astragali, 30-60 parts Radix Codonopsis, 30-60 part moxibustions radix glycyrrhizae, 30-60 parts matrimony vine, 15-45 parts root of herbaceous peony, 15-
45 parts of donkey-hide gelatin, 15-45 parts hen egg yolk, 5-25 part Poria cocos.
3. a kind of Chinese medicine composition for improving sleep function as claimed in claim 1, it is characterised in that by following parts by weight
Component be made：95 parts of ginsengs, 80 parts of seed of Oriental arborvitaes, 80 parts of spina date seeds, 80 parts of Rhizoma Sparganiis, 45 parts of sealworts, 45 parts of radix scutellariaes, 40 parts of Huangs
Stilbene, 40 parts of Radix Codonopsis, 55 parts of moxibustion radix glycyrrhizaes, 45 portions of matrimony vines, 30 portions of root of herbaceous peonys, 33 parts of donkey-hide gelatin, 33 parts of hen egg yolks, 15 parts of Poria cocos, 15 part three
Rib.
A kind of 4. Chinese medicine composition of improvement sleep function as described in claim 1-3 any one, it is characterised in that：According to
Tablet, pill, powder, electuary or capsule is made in Chinese patent drug routine techniques.
5. a kind of preparation method of the Chinese medicine composition of improvement sleep function as described in claim 1-3 any one, it is special
Sign is：
Step 1, each component is weighed by above-mentioned parts by weight；
Step 2, by the seed of Oriental arborvitae weighed, spina date seed, Rhizoma Sparganii, sealwort, radix scutellariae, the Radix Astragali, Radix Codonopsis, moxibustion radix glycyrrhizae, matrimony vine, hen egg yolk,
Poria cocos shreds respectively, mixes, obtains medicinal mixture, adds cold water to soak 20-30 minutes to 2-3 centimetres of medicinal mixture is not crossed,
Use slow fire after ebuillition of heated instead with high heat again and decoct 40-60 minutes slowly, need to be stirred 2-5 times when boiling medicine, with antiseptic gauze residue collection
Decoction；
Step 3,60-100 part ginsengs are weighed, divide pot separately to decoct, add cold water to no 2-3 centimetres of ginseng of mistake, it is military after cold soaking 20-30 minutes
Fire boils, and slow fire decocts 60-120 minutes slowly, with antiseptic gauze residue collection decoction；
Step 4：Donkey-hide gelatin will be added after step 2 and step 3 gained decoction quickly mixing, continuously stirred 15 minutes, it is complete to donkey-hide gelatin
It is dissolved in decoction, obtains improving the Traditional Chinese medicine composition liquid medicine of sleep.
6. a kind of Chinese medicine composition of improvement sleep function as described in claim 1-3 any one is preparing improvement sleep medicine
Application in thing.
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Cited By (2)
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| CN117044944A (en) * | 2023-08-25 | 2023-11-14 | 深圳市绿航星际太空科技研究院 | Sleep-promoting formula and preparation method and application thereof |
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| CN108295240A (en) * | 2018-04-08 | 2018-07-20 | 黑龙江军门现代农业发展有限公司 | A kind of ginseng oral liquid of invigorating qi for tranquilization and preparation method thereof |
| CN117044944A (en) * | 2023-08-25 | 2023-11-14 | 深圳市绿航星际太空科技研究院 | Sleep-promoting formula and preparation method and application thereof |
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Application publication date: 20171124 |