CN115282207A - Spray for treating rhinitis and preparation process thereof - Google Patents
Spray for treating rhinitis and preparation process thereof Download PDFInfo
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- 206010039083 rhinitis Diseases 0.000 title claims abstract description 59
- 239000007921 spray Substances 0.000 title claims abstract description 35
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to a spray for treating rhinitis and a preparation process thereof, wherein the spray is prepared from 30-50 parts of groundsel, 20-30 parts of fried cocklebur fruit, 15-20 parts of divaricate saposhnikovia root, 10-20 parts of povidone K30, 15-25 parts of magnolia flower, 10 to 30 parts of heartleaf houttuynia herb, 15-25 parts of liquorice, 10-20 parts of baical skullcap root and 5-15 parts of largehead atractylodes rhizome according to a certain proportion. The product not only has good effect on treating rhinitis, but also has the advantages of wide material sources, low cost, simple and convenient process operation and the like.
Description
Technical Field
The invention relates to a spray for treating rhinitis and a preparation process thereof, belonging to the field of traditional Chinese medicines.
Background
Rhinitis, that is, inflammatory disease of nasal cavity, is inflammation of nasal mucosa caused by virus, bacteria, various physicochemical factors and some systemic diseases, and rhinitis can be classified into chronic rhinitis, acute rhinitis, atrophic rhinitis, rhinitis medicamentosa, allergic rhinitis and the like according to symptoms. Although the chronic rhinitis occurs slowly, the chronic rhinitis has long-term intermittent or alternative nasal obstruction, which often causes people to breathe smoothly, dizziness and brain swelling; the nasal cavity and the nasopharynx of the patient with the acute rhinitis have the symptoms of obvious dryness, burning sensation, nasal itching, fever, rhinorrhea and the like, so that the body and mind of the patient are exhausted, the smell is reduced sharply, the patient is dizziness and insomnia, and the life and rest of the patient are seriously influenced; atrophic rhinitis, although it is characterized by slow onset of chronic rhinitis, manifests as marked off-flavor in breathing, lumpy mucous membrane secretion and difficult blowing, accompanied by a small amount of nose bleeding when hard-to-pull out the dry scab; rhinitis medicamentosa is usually caused by long-term use of certain drugs which injure nasal mucosa by patients, and nasal obstruction and nasal discharge are often accompanied by nosebleed. The allergic rhinitis is usually caused by the allergy of patients to the surrounding environment, and with the increase of the pressure of modern life and the complex and changeable environment, such as environmental pollution, extreme weather change, sudden temperature drop and the like, more and more people suffer from rhinitis, especially the allergic rhinitis and the chronic rhinitis are prominent, so that the research and development of the rhinitis drug with good treatment effect has wide market prospect.
The existing rhinitis treatment medicines are divided into two types, namely traditional Chinese medicines and western medicines, most of which are spray formulation products, the western medicines not only have the characteristics of quick drug effect, obvious acute inflammation relieving effect and the like, but also have the advantages of few types of formula medicines, easily controlled drug concentration, low cost and the like, but most of the western medicines are hormone medicines, have large side effect and are not easy to use for a long time. Although traditional Chinese medicines have the advantages of small side effect, high cure rate after long-term use and the like, the traditional processing technology has low medicine acquisition rate and slow medicine effect, and most of the traditional Chinese medicines are relatively expensive Chinese herbal medicines, so that the cost is relatively high. Therefore, by combining the characteristics of the traditional Chinese medicine and the western medicine, the product develops the spray for treating rhinitis and the preparation process thereof, and the product not only has good treatment effect on the rhinitis, but also has the advantages of wide material sources, low cost, simple and convenient process operation and the like.
Disclosure of Invention
The invention aims to provide a spray for treating rhinitis.
Yet another object of the present invention is to: provides a preparation process of the spray for treating rhinitis.
The purpose of the invention is realized by the following scheme: a spray for treating rhinitis comprises, by weight, 30-50 parts of groundsel, 20-30 parts of fried cocklebur fruit, 15-20 parts of divaricate saposhnikovia root, 10-20 parts of povidone K30, 15-25 parts of magnolia flower, 10 to 30 parts of heartleaf houttuynia herb, 15-25 parts of liquorice, 10-20 parts of baical skullcap root and 5-15 parts of largehead atractylodes rhizome.
The invention also provides a preparation process of the spray for treating rhinitis, which comprises the following steps:
1) Cleaning the groundsel, the fried cocklebur fruit, the divaricate saposhnikovia root, the magnolia flower, the heartleaf houttuynia herb, the liquoric root, the baical skullcap root and the largehead atractylodes rhizome in the above dosage, drying in the air and grinding into powder; then, the user can use the device to perform the operation,
2) Adopting a steam distillation method to obtain volatile oil of magnolia flower and bighead atractylodes rhizome for later use, and reserving dregs of a decoction;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2), the ethanol extract obtained in the step 3) and povidone K30 dissolved in 85% ethanol under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the compound rhinitis spray.
Is prepared from 30-50 parts of groundsel, 20-30 parts of fried cocklebur fruit, 15-20 parts of divaricate saposhnikovia root, 10-20 parts of povidone K30, 15-25 parts of magnolia flower, 10 to 30 parts of heartleaf houttuynia herb, 15-25 parts of liquoric root, 10-20 parts of baical skullcap root and 5-15 parts of largehead atractylodes rhizome according to a certain proportion. Firstly, cleaning and airing the groundsel, the fried cocklebur fruit, the divaricate saposhnikovia root, the magnolia flower, the houttuynia cordata, the liquorice, the scutellaria baicalensis and the bighead atractylodes rhizome in the above dosage, grinding into powder, then obtaining volatile oil of the magnolia flower and the bighead atractylodes rhizome by adopting a steam distillation method for later use, and reserving dregs of a decoction; soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; then the residual medicine dregs are merged and boiled for 30 min, filtered to remove dregs, cooled, and then added with the volatile oil obtained by distillation, ethanol extract and povidone K30 dissolved by 85 percent ethanol under stirring, and then the pH value is adjusted to 6.0 to 6.5 by phosphate buffer solution, and finally the mixture is subpackaged into bottles, sealed and sterilized to obtain the rhinitis re-spraying agent.
The invention relates to a spray for treating rhinitis and a preparation process thereof, wherein the medicament has greatly increased extraction rate and concentration of active ingredients in the Chinese medicament by means of steam distillation, ethanol leaching and the like, the selected Chinese medicinal materials are safe and have no side effect, the material is widely available, the cost is lower, the spray which is convenient to use and better to absorb is prepared by combining a modern process, and the spray has good treatment effects on chronic rhinitis, acute rhinitis, atrophic rhinitis, drug rhinitis, allergic rhinitis and the like.
Drawings
FIG. 1 is a schematic view of the process.
Detailed Description
Example 1
The rhinitis compound spray is prepared by the following steps as shown in a flow chart 1:
1) Respectively grinding 30 parts of groundsel, 20 parts of fried cocklebur fruit, 15 parts of divaricate saposhnikovia root, 15 parts of magnolia flower, 10 parts of houttuynia cordata, 15 parts of liquorice, 10 parts of scutellaria baicalensis and 10 parts of bighead atractylodes rhizome into powder; then, the user can use the device to perform the operation,
2) Adopting a steam distillation method to obtain volatile oil of magnolia flower and bighead atractylodes rhizome for later use, and reserving dregs of a decoction;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2), the ethanol extract obtained in the step 3) and povidone K30 dissolved in 85% ethanol under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the compound rhinitis spray.
Example 2
The rhinitis compound spray is prepared by the following steps as shown in a flow chart 1:
1) Respectively grinding 30 parts of groundsel, 20 parts of fried cocklebur fruit, 15 parts of divaricate saposhnikovia root, 15 parts of magnolia flower, 10 parts of houttuynia cordata, 15 parts of liquorice, 10 parts of scutellaria baicalensis and 10 parts of bighead atractylodes rhizome into powder; then, the user can use the device to perform the operation,
2) Adopting a steam distillation method to obtain volatile oil of magnolia flower and bighead atractylodes rhizome for later use, and reserving dregs of a decoction;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2) and the ethanol extract in the step 3) under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the rhinitis compound spray.
Example 3
The rhinitis compound spray is prepared by the following steps as shown in a flow chart 1:
1) Respectively grinding 50 parts of groundsel, 30 parts of fried cocklebur fruit, 20 parts of divaricate saposhnikovia root, 25 parts of magnolia flower, 30 parts of houttuynia cordata, 25 parts of liquorice, 20 parts of scutellaria baicalensis and 15 parts of bighead atractylodes rhizome into powder; then, the user can use the device to perform the operation,
2) Adopting a steam distillation method to obtain volatile oil of magnolia flower and bighead atractylodes rhizome for later use, and reserving dregs of a decoction;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2), the ethanol extract obtained in the step 3) and povidone K30 dissolved in 85% ethanol under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the compound rhinitis spray.
Clinical examination
In order to verify the treatment effect of the medicine on various types of rhinitis, clinical experiments are carried out on the medicine
Test object
According to the sorting standard, 10 patients with chronic rhinitis, acute rhinitis, atrophic rhinitis, rhinitis medicamentosa and allergic rhinitis are respectively selected to use the product spray, 3 times a day and continuously for one month.
Sorting standard of chronic rhinitis patients: intermittent or alternate nasal obstruction for a long time, people are not smooth in breathing and dizziness;
sorting standard of acute rhinitis patients: the nasal cavity and the nasopharynx have obvious symptoms of dryness, burning sensation, itching, fever, rhinorrhea and the like;
sorting standard of atrophic rhinitis patients: breath has obvious peculiar smell, mucous membrane secretion is formed into blocks and is not easy to blow out, and when dry scab is forcibly pulled out, the symptoms of small amount of nose bleeding and the like are accompanied;
sorting standard of patients with drug-induced rhinitis: patients take certain medicines which injure nasal mucosa for a long time, and the symptoms of nasal obstruction, nasal discharge, nosebleed and the like are often accompanied;
sorting standard of allergic rhinitis patients: sneezing, watery nasal discharge, and sensitivity to sudden drop of temperature;
the rhinitis spray has the following treatment results:
in the experiment, patients with acute rhinitis, atrophic rhinitis, drug rhinitis and allergic rhinitis are completely cured, 10 patients with acute rhinitis are obviously improved, 8 patients are completely cured, and 2 patients are changed into slight symptoms. The result shows that the rhinitis spray has good curative effect on various types of rhinitis, and the product has obvious effect on treating the rhinitis.
Claims (7)
1. A spray for treating rhinitis is characterized in that: comprises 30-50 parts of groundsel, 20-30 parts of fried cocklebur fruit, 15-20 parts of divaricate saposhnikovia root, 115-25 parts of magnolia flower, 10-30 parts of heartleaf houttuynia herb, 15-25 parts of liquorice, 10-20 parts of baical skullcap root and 5-15 parts of largehead atractylodes rhizome by weight.
2. The spray for treating rhinitis according to claim 1, wherein: also comprises 0-20 parts of polyvidone K30.
3. A process for preparing the spray for treating rhinitis according to claim 1, which is characterized in that:
1) Cleaning herba Senecionis Scandentis, parched fructus Xanthii, radix Saposhnikoviae, flos Magnoliae, herba Houttuyniae, glycyrrhrizae radix, scutellariae radix, and Atractylodis rhizoma, air drying, and grinding into powder; then, the user can use the device to perform the operation,
2) Adopting a steam distillation method to obtain volatile oil of magnolia flower and bighead atractylodes rhizome for later use, and reserving dregs of a decoction;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2), the ethanol extract in the step 3) and povidone K30 dissolved in 85% ethanol under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully and uniformly mixing, subpackaging into bottles, sealing and sterilizing to obtain the compound rhinitis spray.
4. A process for preparing the spray for treating rhinitis according to claim 3, wherein: when the product is prepared, volatile oil of magnolia flower and bighead atractylodes rhizome is obtained by a distillation method, and active ingredients of the medicine are extracted from other herbal medicines by an ethanol leaching method.
5. The process for preparing the spray for treating rhinitis according to claim 3 or 4, wherein: comprises the following steps:
1) Respectively grinding 30 parts of groundsel, 20 parts of fried cocklebur fruit, 15 parts of divaricate saposhnikovia root, 15 parts of magnolia flower, 10 parts of houttuynia cordata, 15 parts of liquorice, 10 parts of scutellaria baicalensis and 10 parts of bighead atractylodes rhizome into powder; then, the user can use the device to perform the operation,
2) Adopting a steam distillation method to obtain volatile oil of magnolia flower and bighead atractylodes rhizome for later use, and reserving dregs of a decoction;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2), the ethanol extract obtained in the step 3) and povidone K30 dissolved in 85% ethanol under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the compound rhinitis spray.
6. The process for preparing the spray for treating rhinitis according to claim 3 or 4, wherein: comprises the following steps:
1) Respectively grinding 30 parts of groundsel, 20 parts of fried cocklebur fruit, 15 parts of divaricate saposhnikovia root, 15 parts of magnolia flower, 10 parts of houttuynia cordata, 15 parts of liquorice, 10 parts of scutellaria baicalensis and 10 parts of bighead atractylodes rhizome into powder; then, the user can use the device to perform the operation,
2) Obtaining volatile oil of flos Magnoliae and Atractylodis rhizoma by steam distillation, and keeping the residue;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2) and the ethanol extract in the step 3) under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the rhinitis compound spray.
7. The process for preparing the spray for treating rhinitis according to claim 3 or 4, wherein: comprises the following steps:
1) Respectively grinding 50 parts of groundsel, 30 parts of fried cocklebur fruit, 20 parts of divaricate saposhnikovia root, 25 parts of magnolia flower, 30 parts of houttuynia cordata, 25 parts of liquorice, 20 parts of scutellaria baicalensis and 15 parts of bighead atractylodes rhizome into powder; then, the user can use the device to perform the operation,
2) Obtaining volatile oil of flos Magnoliae and Atractylodis rhizoma by steam distillation, and keeping the residue;
3) Soaking Concha Haliotidis, parched fructus Xanthii, radix Saposhnikoviae, herba Houttuyniae, glycyrrhrizae radix, and Scutellariae radix powder in 60% ethanol container, sealing, keeping at 40 deg.C, shaking in dark for 1 day to obtain ethanol extractive solution; after that time, the user can use the device,
4) And (3) combining the residual medicine residues, decocting in water for 30 min, filtering to remove residues, cooling, sequentially adding the volatile oil obtained by distillation in the step 2), the ethanol extract obtained in the step 3) and povidone K30 dissolved in 85% ethanol under stirring, adjusting the pH to 6.0-6.5 by using a phosphate buffer solution, fully mixing uniformly, and finally subpackaging into bottles, sealing and sterilizing to obtain the rhinitis compound spray.
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Application publication date: 20221104 |