WO2020119255A1

WO2020119255A1 - Dioscorea alata formula granules and preparation method therefor

Info

Publication number: WO2020119255A1
Application number: PCT/CN2019/112575
Authority: WO
Inventors: 廖年生; 胡贤德; 眭荣春; 邹明明
Original assignee: 江西赣隆药业有限公司
Priority date: 2018-12-10
Filing date: 2019-10-22
Publication date: 2020-06-18
Also published as: CN109846829A

Abstract

Disclosed are dioscorea alata formulation granules and a preparation method therefor, relating to the technical field of TCM formula granules. The preparation method comprises the following steps: (1) getting the medical material dioscorea alata, adding water with an amount of 8 to 10 times to the material, heating and boiling for 1 to 3 hours, extracting twice or 3 times, filtering, and decompressing and concentrating the filtrate to a thick paste with the relative density of 1.1 to 1.2 so as to obtain the dioscorea alata extraction; (2) getting the dioscorea alata extraction, adding an appropriate amount of pharmaceutically acceptable ingredients, mixing, drying, collecting dry paste powder, smashing, sieving with a 80-mesh sieve, and placing the mixture into the mixing groove for mixing; (3) getting the dioscorea alata paste powder, making into granules, and sieving the granules with a 20-mesh sieve and a 50-mesh sieve to obtain dioscorea alata formula granules. The dioscorea alata formula granules prepared by the method have higher contents of active components, and are uniform in size.

Description

Ginseng potato formula particles and preparation method thereof

Technical field

The invention relates to the technical field of traditional Chinese medicine formula particles, in particular to a ginseng potato formula particle and a preparation method thereof.

Background technique

The traditional Chinese medicine granules are made of traditional Chinese medicine pieces as raw materials. After modern processing technology and pharmaceutical technology, the whole ingredients of the medicinal materials are extracted, separated, concentrated, dried, granulated and packaged. They do not require decoction and can be directly formulated and Granules for taking. The traditional Chinese medicine formula granules not only retain the effective ingredients, indications and effects of traditional Chinese medicine decoction pieces, but also have the advantages of uniform standards, stable curative effect, easy to carry and easy to adjust. Complementary medicine.

Ginseng is derived from the dried tubers of Dioscorea alata (Dioscoreaalata L.), which is mainly produced in Zhejiang, Jiangxi, Guangdong, Guangxi, Hunan, Hubei, Sichuan, Fujian and other places. The tubers contain various components such as diosgenin, ginseng polysaccharides, polyphenols and so on. It has the functions of strengthening the spleen, nourishing the lungs, benefiting qi, reducing swelling, and analgesic. It is mainly used for spleen deficiency, diarrhea, lung deficiency, cough, edema, urination, and spermatorrhea. However, there is currently no report on Shenshu formula granules and their preparation process.

Summary of the invention

The purpose of the invention is to provide a ginseng potato granule and a preparation method thereof.

The invention provides a method for preparing ginseng potato granules. The method includes the following steps:

(1) Take ginseng potato herbs, add 8-10 times the amount of water, heat and cook for 1-3 hours, extract 2-3 times, filter, the filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.1-1.2, Ginseng potato extract;

(2) Take the ginseng potato extract, add an appropriate amount of pharmaceutically acceptable auxiliary materials to mix, dry, collect the dry paste powder, pulverize through an 80 mesh sieve, and mix in a mixing tank;

(3) Take the ginseng potato paste powder, granulate, and granulate the granules successively with a 20 mesh sieve and a 50 mesh sieve to obtain ginseng potato formula granules.

Preferably, in step (1), the decoction temperature is 85-95°C.

Preferably, in step (2), the drying method is contact drying, airflow drying, tunnel oven drying, vacuum drying, boiling drying, freeze drying, far infrared drying or microwave drying.

Preferably, the auxiliary material is at least one of soluble starch, starch, lactose, sucrose and dextrin. Further preferably, the auxiliary material is a mixture of starch, lactose and dextrin. Even more preferably, the mixing weight ratio of starch, lactose and dextrin is 1:0.01-0.5:0.1-2.

The invention also provides the ginseng potato granules prepared by the above method.

Preferably, the specifications of the ginseng potato granules are equivalent to 5-15 grams of ginseng medicinal materials per 1-3 grams. The ginseng potato granules contain ginseng potato polysaccharides not less than 50 mg/g, preferably 50-200 mg/g.

The beneficial effects of the present invention are:

(1) According to the method of the present invention, the main active ingredients (such as diosgenin, ginseng polysaccharides, polyphenols) in ginseng medicinal materials can be fully extracted, which can effectively remove inactive ingredients such as plant fibers and improve The medicine is stable, easy to store and easy to take.

(2) The ginseng potato granules prepared according to the method of the present invention have good particle shape and uniform particle size.

(3) In the method described in the present invention, the ginseng potato medicinal material is directly used as the raw material for preparation, which is convenient to implement and easy to realize industrialization.

detailed description

The specific embodiments of the present invention will be described in detail below. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

The endpoints and any values of the ranges disclosed herein are not limited to the precise ranges or values, and these ranges or values should be understood to include values close to these ranges or values. For numerical ranges, between the end points of each range, between the end points of each range and individual point values, and between individual point values can be combined with each other to obtain one or more new numerical ranges, these values The scope should be considered as specifically disclosed herein.

The preparation method of the ginseng potato formula particles according to the present invention includes the following steps:

(1) Take the ginseng potato herbs, add 8-10 times the amount of water, heat and cook for 1-3 hours, extract 2-3 times, filter, and the filtrate is concentrated under reduced pressure to a relative density of 1.1-1.2 (with the concentration of water It is 1g/cm ³ ) thick ginseng, and the ginseng potato extract can be obtained;

In step (1), the amount of water to be fed is 8-10 times the ginseng medicinal material by volume, specifically, for example, 8 times, 8.5 times, 9 times, 9.5 times, or 10 times. In the method of the present invention, the ginseng medicinal herbs and water are fed in such a volume ratio, and the main active ingredients in the ginseng medicinal herbs can be fully extracted.

In step (1), the decoction time is 1-3 hours, specifically, for example, 1 hour, 1.5 hours, 2 hours, 2.5 hours, or 3 hours. In the method of the present invention, the decoction time of the ginseng and medicinal materials in water is within the above range, the main active ingredients in the ginseng and medicinal materials can be sufficiently extracted, and the denaturation of the active ingredients can be prevented. In a preferred case, the temperature of decoction is controlled within the range of 85-95° C., so as to fully extract the active ingredient and maintain the active ingredient with better medicinal effects.

In step (1), the number of extractions is 2-3. The extraction method can be implemented according to conventional methods in the art.

In step (1), the filter can be filtered by a conventional filter screen in the art. In a specific embodiment, the filter may be a stainless steel wire mesh with a mesh size of 200 mesh.

In step (2), the drying method may be contact drying, airflow drying, tunnel oven drying, vacuum drying, boiling drying, freeze drying, far infrared drying or microwave drying. In a preferred case, the drying method is freeze drying.

In step (2), preferably, the auxiliary material is at least one of soluble starch, starch, lactose, sucrose and dextrin. Further preferably, the auxiliary material is a mixture of starch, lactose and dextrin. When the auxiliary material is a mixture of starch, lactose and dextrin, the mixing weight ratio of the three is preferably 1:0.01-0.5:0.1-2.

In step (2), the addition amount of the auxiliary material is such that the specifications of the ginseng potato formula particles are equivalent to 5-15 grams of ginseng medicinal materials per 1-3 grams.

In step (3), the granulation method may be sieving the ginseng potato paste powder for granulation.

In step (3), by granulating the granules obtained after granulation with a 20-mesh sieve and a 50-mesh sieve, the ginseng potato granules with uniform particle size can be obtained.

Preferably, the specifications of the ginseng potato formula granules are equivalent to 5-15 grams of ginseng potato medicinal materials per 1-3 grams, specifically, each gram of the ginseng potato granules are equivalent to 5 grams of ginseng potato medicinal materials, each 2 Grams of the ginseng potato granules are equivalent to 10 grams of ginseng raw medicinal materials, and every 3 grams of the ginseng potato granules are equivalent to 15 grams of ginseng raw medicinal materials.

Preferably, the ginseng potato granules contain ginseng potato polysaccharide not less than 50 mg/g, preferably 50-200 mg/g.

The present invention will be described in detail below through examples.

Example 1

(1) Take 1kg of ginseng and medicinal herbs, add 9 times the amount of water, heat to 90°C and cook for 2 hours, extract twice, filter with 200 mesh stainless steel wire mesh, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.1 , The ginseng potato extract;

(2) Take the ginseng potato extract, add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to mix, freeze-dry, collect the dry paste powder, crush through an 80 mesh sieve, set and mix Tank mixing

(3) Take the ginseng potato paste powder, sieve and granulate, and then granulate the particles with a 20-mesh sieve and a 50-mesh sieve in turn to obtain the ginseng potato granule sample A1.

Example 2

(1) Take 1kg of ginseng medicinal herbs, add 8 times the amount of water, heat to 85°C for 3 hours, extract 3 times, filter with 200 mesh stainless steel wire mesh, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.2 , The ginseng potato extract;

(2) Take the ginseng potato extract, add 80g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to mix, freeze-dry, collect the dry paste powder, pulverize through an 80 mesh sieve, set and mix Tank mixing

(3) Take the ginseng potato paste powder, sieve and granulate, and then granulate the particles with a 20-mesh sieve and a 50-mesh sieve to obtain the ginseng potato granule sample A2.

Example 3

(1) Take 1kg ginseng medicinal herbs, add 10 times the amount of water, heat to 95°C and cook for 2 hours, extract twice, filter with 200 mesh stainless steel wire mesh, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.15 , The ginseng potato extract;

(2) Take the ginseng potato extract, add 50g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to mix, freeze-dry, collect the dry paste powder, crush through an 80 mesh sieve, set and mix Tank mixing

(3) Take the ginseng potato paste powder, sieve and granulate, and then granulate the particles with a 20-mesh sieve and a 50-mesh sieve to obtain ginseng potato granule sample A3.

Example 4

(1) Take 1kg of ginseng medicinal herbs, add 8.5 times the amount of water, heat to 87°C and cook for 1.5 hours, extract twice, filter with 200 mesh stainless steel wire mesh, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.13 , The ginseng potato extract;

(2) Take the ginseng potato extract, add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.4:0.8) to mix, freeze-dry, collect the dry paste powder, crush through an 80 mesh sieve, set and mix Tank mixing

(3) Take the ginseng potato paste powder, sieve and granulate, and then granulate the particles with a 20-mesh sieve and a 50-mesh sieve to obtain the ginseng potato granule sample A4.

Example 5

(1) Take 1kg of ginseng medicinal herbs, add 9.5 times the amount of water, heat to 92°C and cook for 2.5 hours, extract twice, filter with 200 mesh stainless steel wire mesh, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.17 , The ginseng potato extract;

(2) Take the ginseng potato extract, add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.1:1.5) to mix, freeze-dry, collect the dry paste powder, crush through an 80 mesh sieve, set and mix Tank mixing

(3) Take the ginseng potato paste powder, sieve and granulate, and then granulate the particles with a 20-mesh sieve and a 50-mesh sieve to obtain the ginseng potato granule sample A5.

Comparative Example 1

The ginseng potato granules were prepared according to the method of Example 1, except that the dosage of water in step (1) was 7 times that of the ginseng potato medicinal materials, thereby preparing the ginseng potato granules sample D1.

Comparative Example 2

The ginseng potato granules were prepared according to the method of Example 1, except that the dosage of water in step (1) was 12 times that of the ginseng potato medicinal materials, thereby preparing the ginseng potato granules sample D2.

Comparative Example 3

The ginseng potato granules were prepared according to the method of Example 1, except that the granulated granules in step (3) did not pass through a 20 mesh sieve and a 50 mesh sieve, thereby preparing ginseng potato granule sample D3.

Test case

(1) The content of diosgenin and ginseng polysaccharide in the samples of ginseng and potato granules prepared in the above examples and comparative examples is detected, and the chromatographic column used for the detection is a C18 chromatographic column.

(2) Use a particle size distribution analyzer to detect the particle size distribution of the red dry lotus formula particle samples prepared in the above examples and comparative examples, and analyze and calculate the particle number percentage U _0.25- of the particle size within the range of 0.25-0.35mm _0.35 .

The test results are shown in Table 1 below.

Table 1

实施例编号Example number	薯蓣皂苷元含量(mg/g)Diosgenin content (mg/g)	参薯多糖含量(mg/g)Ginseng polysaccharide content (mg/g)	U _0.25-0.35 U _0.25-0.35
实施例1Example 1	127127	8181	94％94%

实施例2Example 2	156156	123123	92％92%
实施例3Example 3	184184	155155	95％95%
实施例4Example 4	126126	8080	95％95%
实施例5Example 5	125125	8282	93％93%
对比例1Comparative Example 1	8989	4343	90％90%
对比例2Comparative Example 2	9797	4545	89％89%
对比例3Comparative Example 3	127127	8181	27％27%

It can be seen from the results in Table 1 that the ginseng potato formulation particles prepared by the method of the present invention have a higher content of active components, and the particle size is uniform.

The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited thereto. Within the scope of the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, including the combination of various technical features in any other suitable manner. These simple modifications and combinations should also be regarded as the disclosure of the present invention. All belong to the protection scope of the present invention.

Claims

A method for preparing ginseng potato granules, characterized in that the method includes the following steps:

(1) Take ginseng potato herbs, add 8-10 times the amount of water, heat and cook for 1-3 hours, extract 2-3 times, filter, the filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.1-1.2, Ginseng potato extract;

(2) Take the ginseng potato extract, add an appropriate amount of pharmaceutically acceptable auxiliary materials to mix, dry, collect the dry paste powder, pulverize through an 80 mesh sieve, and mix in a mixing tank;

(3) Take the ginseng potato paste powder, granulate, and granulate the granules successively with a 20 mesh sieve and a 50 mesh sieve to obtain ginseng potato formula granules.
The method according to claim 1, characterized in that in step (1), the decoction temperature is 85-95°C.
The method according to claim 1, characterized in that in step (2), the drying method is contact drying, airflow drying, tunnel oven drying, vacuum drying, boiling drying, freeze drying, far infrared drying or Microwave drying.
The method according to claim 1, wherein the auxiliary material is at least one of soluble starch, starch, lactose, sucrose and dextrin.
The method according to claim 4, wherein the auxiliary material is a mixture of starch, lactose and dextrin.
The method according to claim 5, wherein the weight ratio of starch, lactose and dextrin is 1:0.01-0.5:0.1-2.
The ginseng potato granules prepared by the method according to any one of claims 1-6.
The ginseng potato granules according to claim 7, characterized in that the size of the ginseng potato granules is equivalent to 5-15 grams of ginseng potato medicinal materials per 1-3 grams.
The ginseng potato granules according to claim 7 or 8, wherein the ginseng potato granules contain ginseng potato polysaccharides not less than 50 mg/g.
The ginseng potato granules according to claim 9, characterized in that the content of ginseng potato polysaccharides in the ginseng potato granules is 50-200 mg/g.