CN101474333A - Yam dispensing granule as well as preparation method and quality control method thereof - Google Patents

Yam dispensing granule as well as preparation method and quality control method thereof Download PDF

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Publication number
CN101474333A
CN101474333A CN 200810184564 CN200810184564A CN101474333A CN 101474333 A CN101474333 A CN 101474333A CN 200810184564 CN200810184564 CN 200810184564 CN 200810184564 A CN200810184564 A CN 200810184564A CN 101474333 A CN101474333 A CN 101474333A
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CN
China
Prior art keywords
rhizoma dioscoreae
spray drying
yam
decoction pieces
shallow oil
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CN 200810184564
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Chinese (zh)
Inventor
吴玢
付静
张翠
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北京康仁堂药业有限公司
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Priority to CN200710179748.2 priority
Application filed by 北京康仁堂药业有限公司 filed Critical 北京康仁堂药业有限公司
Priority to CN 200810184564 priority patent/CN101474333A/en
Publication of CN101474333A publication Critical patent/CN101474333A/en

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Abstract

The invention discloses a yam prescription granule, a preparation method and a quality control method thereof. The yam prescription granule takes yam herbal pieces prepared for decoction as the raw material and is prepared by the processes of twice extraction by water, reduced pressure concentration, spray drying, and the like; each gram of the yam prescription granule corresponds to 5-10g of crude drug dosage; the quality of both yam herbal pieces prepared for decoction and yam prescription granule is identified by infrared fingerprint spectra. The yam prescription granule of the invention has integral and advanced preparation process and specific and controllable quality control standard, wherein, the advanced process can be realized and the detection method related to the quality standard is scientific, advanced and fast and convenient with strong feasibility. Experiments show that the decoction composed by the yam prescription granule of the invention contains the same ingredients as the herbal pieces mixedly decocted liquor containing yam of the classical prescription, the prescription granule process of bulk composition is realized and the process of the invention is reasonable; furthermore, the invention applies the technology of infrared fingerprint spectra to the quality control of the traditional Chinese medicine, thus the primary problem in the macro quality control of the traditional Chinese medicine, namely the authenticity identification of the traditional Chinese medicine is instantly solved.

Description

A kind of Yam dispensing granule and preparation method thereof and method of quality control
Technical field
The present invention relates to a kind of Chinese medicinal granule and preparation method thereof and method of quality control, particularly a kind of Yam dispensing granule and preparation method thereof and method of quality control.
Background technology
Chinese medicinal granule is under Chinese medical theory instructs, and the prepared slices of Chinese crude drugs are formed through various processes, is used for the granule that clinical tcm prescription allotment is used; Compare with traditional Chinese herbs decoction, its taking convenience, dose is little, and is quality controllable, preserves easily, is easy to carry; Chinese medicinal granule is in the pilot production status at home at present, product technology and quality standard disunity.At present Chinese medicinal granule mostly is traditional water and extracts, and perhaps extracts water extraction behind the volatile oil, and different production unit causes the product quality of different manufacturers inconsistent because production equipment is different with production technology, and there is difference in drug effect.The specificity of its quality standard is limit by certain test conditions and scope, lacks other due quality informations of product, and present standard can't be judged the quality good or not and the overall picture of Chinese medicinal granule product comprehensively.
Infrared spectrometry is one of conventional means of differentiating chemical compound and definite structure of matter.In pharmaceutical analysis, " fingerprint " characteristic that has with infrared spectrum is the common method that adopts of various countries' pharmacopeia as the foundation of drug identification.But since Chinese crude drug, the prepared slices of Chinese crude drugs and Chinese patent medicine itself all be more than the Western medicine complexity many mixture systems, the spectrum analysis difficulty makes conventional infrared spectrometry fail its due effect of performance in Chinese medicine quality control and management in the long term.
Summary of the invention
The objective of the invention is to disclose a kind of Yam dispensing granule; The present invention also aims to disclose the preparation method of this granule; The present invention also aims to disclose the method for quality control of this granule.
The present invention seeks to be achieved through the following technical solutions:
The suitable crude drug amount of the every gram of Yam dispensing granule of the present invention 5-10 gram, the Infrared fingerprint spectra of this granule such as Fig. 1.The preparation method of Yam dispensing granule of the present invention comprises: get the Rhizoma Dioscoreae decoction pieces, use twice of water extraction; Wherein the Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, Rhizoma Dioscoreae decoction pieces standard Infrared fingerprint spectra such as Fig. 2.
The preparation method of Yam dispensing granule of the present invention comprises the steps: to get the Rhizoma Dioscoreae decoction pieces, adds the water of 5-15 times of weight portion, extracts 0.5-3 hour, promptly one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Rhizoma Dioscoreae decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule.
The preparation method of Yam dispensing granule of the present invention is preferably as follows step: get the Rhizoma Dioscoreae decoction pieces, add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule.
The preparation method of Yam dispensing granule of the present invention is preferably as follows step: get the Rhizoma Dioscoreae decoction pieces, add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule.
The preparation method of Yam dispensing granule of the present invention is preferably as follows step: get the Rhizoma Dioscoreae decoction pieces, add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule.
The drying process with atomizing parameter is in the above-mentioned preparation method: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature.
The granulation parameter is in the above-mentioned preparation method: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/mins; Feed voltage: 100-150V; Granular size: 20-60 order.
The method of quality control of Yam dispensing granule of the present invention comprises the steps: that Yam dispensing granule adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Yam dispensing granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1022cm -1There is an absworption peak the strongest at the place, and at 1022cm -1The absworption peak at place is the shape at a ladder peak, and its absorption is 1022cm from high to low -1, 1079cm -1, 1154cm -1At 2930cm -1, 1731cm -1, 1630cm -1, 1412cm -1, 763cm -1There is characteristic absorption at the place.
The method of quality control of the Rhizoma Dioscoreae decoction pieces described in the Yam dispensing granule preparation method of the present invention comprises the steps: that the Rhizoma Dioscoreae decoction pieces is the certified products that meet a regulation of Pharmacopoeia of the People's Republic of China version in 2005; The Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: as shown in Figure 2 at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650c -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place.
Infrared fingerprint spectra wherein of the present invention can be to reach Infrared fingerprint spectra more than 90% with its dependency.
Description of drawings:
Fig. 1: the Infrared fingerprint spectra of Yam dispensing granule;
Fig. 2: the Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces Rhizoma Dioscoreae;
Fig. 3: Yam dispensing granule and Rhizoma Dioscoreae decoction pieces thin layer chromatography are relatively;
Fig. 4: Yam dispensing granule and Rhizoma Dioscoreae decoction pieces thin-layer sample Infrared fingerprint spectra are relatively;
Fig. 5: contain Rhizoma Dioscoreae classics side decoction pieces decocting liquid and soup that Yam dispensing granule is joined " whole part " infrared spectrogram relatively.
Complete, advanced production technology that Yam dispensing granule of the present invention has and specificity strong, Controlled quality control standard, technology advanced person can realize, the detection method that quality standard relates to Science, advanced person, quick, workable. By great many of experiments, contrasted the warp that contains the Chinese yam medicine materical crude slice Allusion quotation side's medicine materical crude slice closes decocting liquid and soup that Yam dispensing granule of the present invention is joined " full composition " infrared spectrogram, and is right Compare Yam dispensing granule of the present invention and Chinese yam medicine materical crude slice thin-layer chromatogram, contrasted Yam dispensing granule and mountain Medicine medicine materical crude slice thin-layer sample infrared finger print atlas, the result show the classical side's medicine materical crude slice that contains the Chinese yam medicine materical crude slice close decocting liquid with Yam dispensing granule of the present invention is joined soup infrared finger print atlas peak shape, peak position, Relative Peak intensity basic one Cause, namely to close the decocting liquid composition suitable for soup that Yam dispensing granule of the present invention is joined and medicine materical crude slice, and mountain of the present invention The infrared finger print atlas peak shape of medicine composition particle and medicine materical crude slice thin-layer sample, peak position, Relative Peak intensity basic one Cause, so Yam dispensing granule of the present invention realizes the technology of full component prescription particle, proved worker of the present invention The reasonability of skill; And the present invention is applied to the quality control of Chinese medicine with infrared spectrum technology, and this is a kind of Innovation on the thinking, this not only meets traditional chinese medicine about the theory of " monarch, minister, help, make ", Also given prominence to the group effect of Chinese medicine, simultaneously the problem of complexity oversimplified, certain Chinese medicine as one Integral body is observed its " fingerprint ", thereby has solved rapidly a head in the control of Chinese medicine macroscopic quality Want problem---the evaluation of the Chinese medicine true and false.
Following experimental example and embodiment are used for further specifying but are not limited to the present invention.
Experimental example 1
(1) Yam dispensing granule and the comparative studies of Chinese yam medicine materical crude slice thin-layer chromatography
Get Yam dispensing granule 1g, add methyl alcohol 20ml, added hot reflux 1 hour, let cool, filter, Filtrate evaporate to dryness, residue add methyl alcohol 1ml dissolving, filter, and filtrate is as need testing solution. Other gets the mountain Medicine control medicinal material powder 0.5g is made in the same way of control medicinal material solution. According to thin-layered chromatography (" middle traditional Chinese medicines Allusion quotation " 2005 years appendix VIB of version) test, draw each 5 μ l of mentioned solution, put respectively in On one silica gel g thin-layer plate, take n-butanol-acetic acid-water (13:3:4) as solvent, launch, get Go out, dry, again launch, take out, dry, spray 0.5% ethanol solution of ninhydrin, 105 ℃ of heating Clear to spot colour developing, as shown in Figure 3, in the test sample chromatogram, with control medicinal material chromatogram phase On the position of answering, the spot of aobvious same color.
(2) Yam dispensing granule and Chinese yam medicine materical crude slice thin-layer sample infrared finger print atlas are relatively
Measure the Chinese yam medicine materical crude slice of preparation in (1) and Yam dispensing with FTIS The grain thin-layer sample, its result as shown in Figure 4, the thin layer of Yam dispensing granule and Chinese yam medicine materical crude slice Sample infrared finger print atlas peak shape, peak position, Relative Peak intensity are basically identical.
The result proves that Yam dispensing granule of the present invention is consistent with Chinese yam medicine materical crude slice composition, and technology of the present invention is to close Reason.
Experimental example 2 contains Chinese yam classics side medicine materical crude slice decocting liquid and soup that Yam dispensing granule is joined " full composition " infrared spectrogram comparative experiments
Yihuang decoction comes from "Fu Qingzhu works on obstetric", prescription form comprise golden cypress, gingko, Gorgon fruit, Chinese yam, 5 flavour of a drug of plantain seed; The effect curing metrorrhagia and leukorrhagia.
1, experiment purpose: the similarities and differences of research yihuang decoction medicine materical crude slice decocting liquid and granular recipe, determine Yam dispensing The reasonability of particle technology and equivalent.
2, experimental technique: get 5 flavour of a drug prescriptions such as Chinese yam by yihuang decoction prescription proportioning, press the medicine materical crude slice decoction Decocting method decoct preparation medicine materical crude slice decocting liquid sample; Get except Chinese yam respectively by yihuang decoction prescription proportioning in addition Other medicine materical crude slice, the decocting method of pressing the medicine materical crude slice decoction decocts, and soup suitably concentrates, and presses yihuang decoction prescription proportioning Get Yam dispensing granule with equivalent relation and add in the concentrated medicament, be stirred to fully dissolving, the preparation particle is joined The quadrat sampling product; Drinking respectively sheet decocting liquid sample, granular recipe sample carries out infrared spectrum and detects.
3, testing conditions: instrument is FTIS, and measurement range is 4000 cm-1-400cm -1, DTGS detector, resolution ratio 4cm-1, scanning times 16 times, in the scanning process constantly Deduction water and carbon dioxide disturb, and envionmental humidity is lower than 60%, and the KBr direct compression process is examined Survey.
4, testing result: decoction pieces decocting liquid sample and granular recipe sample Infrared fingerprint spectra peak shape, peak position, relative peak intensity basically identical as shown in Figure 5, dependency reaches 97.03%.It is consistent to prove that soup that Yam dispensing granule of the present invention is joined and decoction pieces close the decocting liquid composition, it is consistent with a Rhizoma Dioscoreae decoction pieces fried composition promptly to add Yam dispensing granule of the present invention, and equivalent and production technology that Yam dispensing granule 1g of the present invention is equivalent to Rhizoma Dioscoreae decoction pieces 5-10g are rational.
Following embodiment all can realize the effect of above-mentioned experimental example, and required Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination among the following embodiment, meets the standard Infrared fingerprint spectra of the Rhizoma Dioscoreae decoction pieces in the technique scheme; The Yam dispensing granule that following embodiment makes adopts Infrared fingerprint spectra to carry out quality discrimination, meets the Infrared fingerprint spectra of the Yam dispensing granule in the technique scheme; The every gram of Yam dispensing granule described in the following embodiment contains suitable crude drug amount 5-10 gram.
The specific embodiment
Embodiment 1: Yam dispensing granule
Get Rhizoma Dioscoreae decoction pieces 100kg, add the water of 800kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 800kg water, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.05-1.10; Concentrated solution is 45 ℃ of preheatings, 180 ℃ of inlet temperature, 550 rev/mins of material revolution speeds, 80 ℃ of leaving air temps, wind send spray drying under the condition of 45 ℃ of temperature, the Rhizoma Dioscoreae spray drying powder; The adjuvant dextrin that in the Rhizoma Dioscoreae spray drying powder, adds himself weight portion 0-5%; The Rhizoma Dioscoreae spray drying powder is 5MPa at main pinch roller pressure, and side pressure wheel pressure is 0.5MPa, and the speed of mainshaft is 400 rev/mins, and feed voltage is a dry granulation under the condition of 120V, 20-60 purpose Yam dispensing granule, suitable crude drug amount 10 grams of the every gram of Yam dispensing granule.
Embodiment 2: Yam dispensing granule
Get Rhizoma Dioscoreae decoction pieces 100kg, add the water of 1000kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 600kg water, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.00-1.05; Concentrated solution is 50 ℃ of preheatings, 170 ℃ of inlet temperature, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Rhizoma Dioscoreae spray drying powder; The adjuvant dextrin that in the Rhizoma Dioscoreae spray drying powder, adds himself weight portion 5-15%; At main pinch roller pressure is 6MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 450 rev/mins, and feed voltage is a dry granulation under the condition of 110V, 20-60 purpose Yam dispensing granule, suitable crude drug amount 7 grams of the every gram of Yam dispensing granule;
The method of quality control of wherein said Rhizoma Dioscoreae decoction pieces comprises the steps: that the Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: as shown in Figure 2 at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650cm -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place.
Embodiment 3: Yam dispensing granule
Get Rhizoma Dioscoreae decoction pieces 100kg, add the water of 1400kg, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 1100kg water, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.10-1.15; Concentrated solution is 45 ℃ of preheatings, 170 ℃ of inlet temperature, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Rhizoma Dioscoreae spray drying powder; The lactose that in the Rhizoma Dioscoreae spray drying powder, adds himself weight portion 15-25%; At main pinch roller pressure is 4MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 500 rev/mins, and feed voltage is a dry granulation under the condition of 130V, 20-60 purpose Yam dispensing granule, suitable crude drug amount 5 grams of the every gram of Yam dispensing granule;
The method of quality control of gained Yam dispensing granule comprises the steps: to adopt Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Yam dispensing granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1022cm -1There is an absworption peak the strongest at the place, and at 1022cm -1The absworption peak at place is the shape at a ladder peak, and its absorption is 1022cm from high to low -1, 1079cm -1, 1154cm -1At 2930cm -1, 1731cm -1, 1630cm -1, 1412cm -1, 763cm -1There is characteristic absorption at the place.

Claims (9)

1, a kind of Yam dispensing granule is characterized in that the suitable crude drug amount of the every gram of described Yam dispensing granule 5-10 gram.
2, a kind of Yam dispensing granule is characterized in that this Yam dispensing granule Infrared fingerprint spectra has following feature: adopt Fourier transform infrared spectrometer to measure, at 1022cm -1There is an absworption peak the strongest at the place, and at 1022cm -1The absworption peak at place is the shape at a ladder peak, and its absorption is 1022cm from high to low -1, 1079cm -1, 1154cm -1At 2930cm -1, 1731cm -1, 1630cm -1, 1412cm -1, 763cm -1There is characteristic absorption at the place.
3, Yam dispensing granule as claimed in claim 1 is characterized in that the Infrared fingerprint spectra of this granule has following feature: at 1022cm -1There is an absworption peak the strongest at the place, and at 1022cm -1The absworption peak at place is the shape at a ladder peak, and its absorption is 1022cm from high to low -1, 1079cm -1, 1154cm -1At 2930cm -1, 1731cm -1, 1630cm -1, 1412cm -1, 763cm -1There is characteristic absorption at the place.
4, a kind of preparation method of Yam dispensing granule is characterized in that this method comprises a kind of in the following method:
Get the Rhizoma Dioscoreae decoction pieces, add the water of 5-15 times of weight portion, extracted 0.5-3 hour, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Rhizoma Dioscoreae decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, Yam dispensing granule;
Or get the Rhizoma Dioscoreae decoction pieces, and add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, Yam dispensing granule;
Or get the Rhizoma Dioscoreae decoction pieces, and add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, Yam dispensing granule;
Or get the Rhizoma Dioscoreae decoction pieces, and add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, Yam dispensing granule.
5, the preparation method of Yam dispensing granule as claimed in claim 4 is characterized in that wherein said drying process with atomizing parameter is: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature; Wherein said granulation parameter is: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/mins; Feed voltage: 100-150V; Granular size: 20-60 order.
6, the preparation method of Yam dispensing granule as claimed in claim 4 is characterized in that wherein the quality discrimination of Rhizoma Dioscoreae decoction pieces Infrared fingerprint spectra is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650cm -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place.
7, a kind of preparation method of Yam dispensing granule is characterized in that this method comprises a kind of in the following method:
Get the Rhizoma Dioscoreae decoction pieces, add the water of 5-15 times of weight portion, extracted 0.5-3 hour, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Rhizoma Dioscoreae decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule; Wherein the Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650cm -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place;
Or get the Rhizoma Dioscoreae decoction pieces, and add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule; Wherein the Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650cm -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place;
Or get the Rhizoma Dioscoreae decoction pieces, and add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule; Wherein the Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650cm -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place;
Or get the Rhizoma Dioscoreae decoction pieces, and add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Rhizoma Dioscoreae decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Rhizoma Dioscoreae spray drying powder; The Rhizoma Dioscoreae spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Rhizoma Dioscoreae spray drying powder, 20-60 purpose Yam dispensing granule; Wherein the Rhizoma Dioscoreae decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Rhizoma Dioscoreae decoction pieces has following feature: at 992cm -1, 1080cm -1, 1161cm -1There are three significantly strong absworption peaks at the place, and is the shape at ladder peak from high to low; At 2931cm -1, 1650cm -1, 1420cm -1, 862cm -1, 767cm -1, 577cm -1There is characteristic absorption at the place.
8, the preparation method of Yam dispensing granule as claimed in claim 7 is characterized in that wherein said drying process with atomizing parameter is: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature; Wherein said granulation parameter is: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/mins; Feed voltage: 100-150V; Granular size: 20-60 order.
9, as claim 2,3 arbitrary described Yam dispensing granules, it is characterized in that wherein said Infrared fingerprint spectra testing conditions is: use Fourier transform infrared spectrometer, measurement range is 4000cm -1-400cm -1, DTGS detector, resolution 4cm -1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects.
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