CN104922681A - Animal enteric film coating solution and preparation method as well as application thereof - Google Patents
Animal enteric film coating solution and preparation method as well as application thereof Download PDFInfo
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- CN104922681A CN104922681A CN201510268644.3A CN201510268644A CN104922681A CN 104922681 A CN104922681 A CN 104922681A CN 201510268644 A CN201510268644 A CN 201510268644A CN 104922681 A CN104922681 A CN 104922681A
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- coating solution
- acrylic resin
- sodium alginate
- enteric
- ethanol
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Abstract
The invention discloses an animal enteric film coating solution and a preparation method as well as application thereof. The invention discloses the animal enteric film coating solution, wherein enteric acrylic resin II, enteric acrylic resin III, diethyl phthalate and sodium alginate are dissolved in ethyl alcohol. The coating solution provided by the invention is compounded through the enteric acrylic resin, is added with the sodium alginate, and generates an obvious synergistic effect, and a medicine is more stable in an acidic condition, and is released more thoroughly in an alkaline condition, so that a coated medicine is enabled to have slow release and synergism.
Description
Technical field
The present invention relates to a kind of medical coating solution, particularly relate to the film coating solution used on enteric veterinary drug, belong to field of veterinary.
Background technology
In farming animals cultivation, one of modal problem is the prevention and therapy of Animal diseases, especially common enterobacteriaceae lactobacteriaceae associated diseases, as escherichia coli, Klebsiella, Proteus, Salmonella, Shigella and hemophilus influenza, legionella pneumophilia, Diplococcus gonorrhoeae etc.For this reason, usually use the antibacterial of such as ofloxacin and so on, thus the diseases such as treatment animal diarrhoea, diarrhoea, typhoid fever, yellow scours, Hakuri.
But the problem that common said medicine exists is poorly water-soluble, need acid adding or alkali to regulate pH when it is water-soluble, but this pH regulator mode often cause conflicting with the pH environment facies of intestinal, affects drug effect; Though its common liquid preparation is easy to use, poor stability, in intestinal environment, rate of release is too fast, easily produces stress.
Summary of the invention
For the deficiencies in the prior art, the invention discloses a kind of enteric film coating solution for animals, it makes to have significant synergism between each composition by composition improvement, medicine can be made more stable in acid condition, discharge more thorough in the basic conditions, make drug coated have sustained-release synergistic effect.
Specifically, the present invention is achieved through the following technical solutions:
A kind of enteric film coating solution for animals, is dissolved with II enteric acrylic resin, III enteric acrylic resin, diethyl phthalate and sodium alginate in ethanol.
In above-mentioned, use II enteric acrylic resin, III enteric acrylic resin ensure that coating effect, use sodium alginate to improve the stability of alcohol solvent system, dissolubility, viscosity and safety, with the use of enteric resin dissolves, make drug release abundant.
In the present invention, the consumption of each composition reasonably can adjust according to practical application, preferably, the usage ratio of each composition is containing II enteric acrylic resin 10-20g, III enteric acrylic resin 10-20g, diethyl phthalate 5-20ml, sodium alginate 6-12g in 1000ml ethanol; More preferably, the usage ratio of each composition is containing II enteric acrylic resin 15g, III enteric acrylic resin 15g, diethyl phthalate 10ml, sodium alginate 10g in 1000ml ethanol.
In the present invention, sodium alginate used is preferably ultra micro sodium alginate, and its particle diameter is not higher than 50 microns.By using ultra micro sodium alginate, improve the dispersion of sodium alginate in dicyandiamide solution and the contact area with other compositions; More preferably, sodium alginate particle diameter used is 25-37 micron.
Accordingly, the invention discloses the preparation method of described Coating Solution, comprise the steps: No. II, III enteric acrylic resin joins in ethanol and dissolve, then diethyl phthalate is added, under stirring, add sodium alginate dissolve to it, finally add ethanol and namely obtain Coating Solution to volume required.
Further, also comprise the step of described Coating Solution through filtering through 100 orders, so that the impurity that filtering surprisingly produces.
The experiment that applicant carries out confirms, Coating Solution of the present invention has good stability and sustained release performance, therefore the invention also discloses the film-coated application of described Coating Solution as enteric agents for animals.
Detailed description of the invention
In order to effect of the present invention is described, applicant provides some specific implementations of the present invention in following, and following enforcement is only schematic, but not forms special restriction to the present invention.Those skilled in the art, understanding and grasping on the basis of connotation of the present invention, still belong to protection scope of the present invention to the change that Ingredient Amount, specification etc. are made.
Embodiment 1
Embodiment 2
Embodiment 3
Comparative example 1
In order to effect of the present invention is described, respectively with embodiment 3 and contrast enforcement 1 for coating material, with common veterinary drug tilmicosin for active component, carry out bag to be processed, conveniently method for coating (granulate by the preparation of microsphere, mixing, ball blast, dry, spray at the bottom of fluid bed, dry) carry out Cotton seeds, after making finished product, carry out the detection of microcapsule dissolution.
Microcapsule dissolution refers to the cumulative release percentage rate (release in vitro) of microcapsule under certain condition, the ratio of the solution concentration namely under certain hour and original concentration.Measure by Chinese Pharmacopoeia nineteen ninety-five version dissolution method paddle method.
Accurately take dry each 6 parts of the microcapsule of 30mg, be dispersed in ZRS-8 type intelligence dissolving-out tester to be equipped with in 6 test tubes of simulated body fluid (the pH7.2 phosphate buffer containing 5% ethanol) and carry out aids drug dispose procedure in intestinal.(37 scholar 0.5) DEG C water bath with thermostatic control, vibrates, respectively at 60 with the speed constant speed of 200r/min, 120,180,240, after 300, by test tube with 4000r/min high speed centrifugation 5min, filter with microporous filter membrane (0.8um), draw 5mL supernatant, measure absorbance with ultraviolet spectrophotometer at 320nm place, add the fresh SBF solution of equivalent simultaneously, keep simulated body fluid constant volume.The concentration of different time microcapsule release thing is calculated according to absorbance and standard absorption curve.Calculate cumulative release percentage rate.
Experimental result is as shown in table 1.
Table 1: the release in vitro dissolution of microcapsule detects
Experimental result shows, the dissolution of the two kinds of tilmicosin microcapsules prepared is in rising trend in time, the dissolution of 240min is less than 50%, there is obvious slow release effect, with do not use compared with sodium alginate micro gel capsule reference substance, little containing the dissolution of sodium alginate coating solution when 300min, display slow release effect is more superior than it, and dissolution in vitro more meets slow release requirement.
Claims (8)
1. an enteric film coating solution for animals, is characterized in that being dissolved with II enteric acrylic resin, III enteric acrylic resin, diethyl phthalate and sodium alginate in ethanol.
2. Coating Solution according to claim 1, is characterized in that the usage ratio of each composition for containing II enteric acrylic resin 10-20g, III enteric acrylic resin 10-20g, diethyl phthalate 5-20ml, sodium alginate 6-12g in 1000ml ethanol.
3. Coating Solution according to claim 2, is characterized in that the usage ratio of each composition for containing II enteric acrylic resin 15g, III enteric acrylic resin 15g, diethyl phthalate 10ml, sodium alginate 10g in 1000ml ethanol.
4. Coating Solution according to claim 1, it is characterized in that sodium alginate used is ultra micro sodium alginate, its particle diameter is not higher than 50 microns.
5. Coating Solution according to claim 4, is characterized in that sodium alginate particle diameter used is 25-37 micron.
6. the preparation method of the Coating Solution of claim 1, it is characterized in that comprising the steps: No. II, III enteric acrylic resin joins in ethanol and dissolve, then diethyl phthalate is added, under stirring, add sodium alginate dissolve to it, finally add ethanol and namely obtain Coating Solution to volume required.
7. preparation method according to claim 6, characterized by further comprising the step of described Coating Solution through filtering through 100 orders.
8. the Coating Solution of claim 1 is as the film-coated application of enteric agents for animals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510268644.3A CN104922681A (en) | 2015-05-23 | 2015-05-23 | Animal enteric film coating solution and preparation method as well as application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510268644.3A CN104922681A (en) | 2015-05-23 | 2015-05-23 | Animal enteric film coating solution and preparation method as well as application thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN104922681A true CN104922681A (en) | 2015-09-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201510268644.3A Pending CN104922681A (en) | 2015-05-23 | 2015-05-23 | Animal enteric film coating solution and preparation method as well as application thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552332A (en) * | 2003-05-30 | 2004-12-08 | 上海华拓医药科技发展有限公司 | Enteric sotuble preparation of Adefuwei double-graded valeryl oxomethyl ester |
| CN101045044A (en) * | 2006-03-27 | 2007-10-03 | 魏秀华 | Thipronin enteric-coated delayed-release agent |
| CN102308916A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel enteric sustained-release pellet for feed and preparation method thereof |
-
2015
- 2015-05-23 CN CN201510268644.3A patent/CN104922681A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552332A (en) * | 2003-05-30 | 2004-12-08 | 上海华拓医药科技发展有限公司 | Enteric sotuble preparation of Adefuwei double-graded valeryl oxomethyl ester |
| CN101045044A (en) * | 2006-03-27 | 2007-10-03 | 魏秀华 | Thipronin enteric-coated delayed-release agent |
| CN102308916A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel enteric sustained-release pellet for feed and preparation method thereof |
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Application publication date: 20150923 |
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