CN102726614A - Feed animal intestinal tract protective agent, preparation method and application thereof - Google Patents
Feed animal intestinal tract protective agent, preparation method and application thereof Download PDFInfo
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- CN102726614A CN102726614A CN2012102310817A CN201210231081A CN102726614A CN 102726614 A CN102726614 A CN 102726614A CN 2012102310817 A CN2012102310817 A CN 2012102310817A CN 201210231081 A CN201210231081 A CN 201210231081A CN 102726614 A CN102726614 A CN 102726614A
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- animal intestinal
- protective agent
- betaine
- vitamin
- feeding animal
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Abstract
The invention discloses a feed animal intestinal tract protective agent, a preparation method and application thereof. Every 1kg of feed animal intestinal tract protective agent comprises 250-350g of yeast polysaccharide, 250-350g of betaine, 1000-2000U of glucose oxidase, (1-2)*10<7>IU of lysozyme, 1.0-2.0g of vitamin E, 0.1-0.5g of vitamin B1, 0.2-0.6g of vitamin B2, 0.1-0.5g of vitamin B6, 0.7-1.2g of nicotinic acid and balance of excipient. The nutritional ingredients are mixed to be uniform, so as to obtain the feed animal intestinal tract protective agent. The feed animal intestinal tract protective agent disclosed by the invention is taken as animal feed additive, can completely substitute for an antibiotic drug, and can achieve the aims of preventing and treating animal intestinal tract diseases, improving production performance of animals and improving feed efficiency.
Description
Technical field
The present invention relates to animal feed, be specifically related to a kind of feeding animal intestinal protective agent as animal feed additive and preparation method thereof.
Background technology
Along with improving constantly of continuous expansion of China's animal husbandry production scale and intensification degree; Various intestines problems (grice diarrhoea, chicken necrotizing enterocolitis, chicken pathogenicity diarrhoea) also demonstrate multiple trend, are example with the grice diarrhoea; The piglet average of the whole year incidence of disease below the 30kg can reach 46.5%; The death rate 10.3%, winter, the incidence of disease can reach 69.9%, and the death rate can reach 19.6%.To the disease that bowel problems causes, mainly in feed, add antibiotic (penicillin, terramycin, flavomycoin etc.) through the raiser exactly at present and solve.Antibiotic reasonable use can be played the raising breeding performonce fo animals in the feed, improves feed efficiency, effects such as prevent disease.But antibiotic use for a long time and abuse the negative effect of bringing also cause concern, be mainly reflected in: the one, germ produces the drug resistance problem; The 2nd, kill beneficial bacterium in the enteron aisle, cause that the animal immune function descends, death increases; The 3rd, the medicament residue problem in the animal products, the directly health of harm humans.
To the harm that antibiotic brings animal and human's body, a lot of countries have all forbidden antibiotic use in the feed in succession.Sweden announced to completely forbid in 1986 in animal and fowl fodder, to use antibiotic for the first time; On January 1st, 2006 rose, and European Union completely forbids food animal and uses the antibiotic feed additive for promoting growth; Japan just forbade the use of all antibiotic in feed since 2008; Korean government adds antibiotic from complete prohibition on July 1 in 2011 animal feed; China Ministry of Agriculture representes that recently for promoting the trust of consumer to livestock products, the plan plan is completely forbidden and in animal feed, added antibiotic.
The forbidding antibiotic is the key that aquaculture is moved towards nature, health in the feed, also is an inexorable trend of aquaculture development.Replacing antibiotic will be the novel fodder additive of some green high-efficients; The development of antibiotic substitute (like probiotics, acidulant, oligosaccharides, antibacterial peptide etc.) becomes various countries scholar's research focus; But it seems at present; The antibiotic difficulty of these products substitutions is very big, can't play the effect of blocking one side alone, and does not also have at present a kind ofly can substitute antibiotic product fully.
Summary of the invention
First technical problem to be solved by this invention is: to the deficiency that prior art exists, provide a kind of through resistance and the immunity of animal intestinal being repaired and safeguarded, keep animal intestinal health, enhancing animal, the feeding animal intestinal protective agent that can substitute the antibiotic use fully.
Second technical problem to be solved by this invention is: to the deficiency that prior art exists, provide a kind of through resistance and the immunity of animal intestinal being repaired and safeguarded, keep animal intestinal health, enhancing animal, the protectant preparation method of feeding animal intestinal that can substitute the antibiotic use fully.
The 3rd technical problem to be solved by this invention is: the deficiency to prior art exists provides the application of a kind of feeding animal intestinal protective agent as animal feed additive.
For solving above-mentioned first technical problem, technical scheme of the present invention is:
A kind of feeding animal intestinal protective agent contains in the feeding animal intestinal protective agent of every 1Kg: zymosan 250～350g, betaine 250～350g, glucose oxidase 1000～2000U, lysozyme (1～2) * 10
7IU, vitamin e1 .0～2.0g, vitamin B1 0.1～0.5g, vitamin B2 0.2～0.6g, vitamin B6 0.1～0.5g and nicotinic acid 0.7～1.2g, surplus is an excipient.
Wherein, mass content >=15% of said excipient in said feeding animal intestinal protective agent.
Preferably, said betaine comprises a kind of or more than one the mixture in hydrochloride betaine, sulphonic acid betaine, phosphate betaine, a water betaine and the anhydrous betaine.
Preferably, said excipient comprises at least a in white carbon, the calcium stearate.
Unit (U) definition of living of glucose oxidase enzyme: under pH6.0,30 ℃ condition, per minute can become maltonic acid and H to the β of 1.0 μ mol-D-glucose oxidase
2O
2The enzyme amount be a unit.
Lysozyme potency unit (IU) definition: when 25 ℃ of room temperatures, pH value 6.2, at wavelength 450nm place, per minute causes that trap decline 0.001 is an enzyme activity unit.
All formula components of feeding intestinal protection of the present invention all can be through commercial acquisition.
For solving above-mentioned second technical problem, technical scheme of the present invention is:
The protectant method of a kind of feeding animal intestinal may further comprise the steps: according to containing zymosan 250～350g, betaine 250～350g, glucose oxidase 1000～2000U, lysozyme (1～2) * 10 in the feeding animal intestinal protective agent of every 1Kg
7The content ratio of the excipient of IU, vitamin e1 .0～2.0g, vitamin B1 0.1～0.5g, vitamin B2 0.2～0.6g, vitamin B6 0.1～0.5g, nicotinic acid 0.7～1.2g and surplus; Above-mentioned various raw materials are mixed, cross 20 mesh sieves and obtain feeding animal intestinal protective agent.
Wherein, mass content >=15% of said excipient in said feeding animal intestinal protective agent.
Preferably, said betaine comprises a kind of or more than one the mixture in hydrochloride betaine, sulphonic acid betaine, phosphate betaine, a water betaine and the anhydrous betaine.
Preferably, said excipient comprises at least a in white carbon, the calcium stearate.
For solving above-mentioned the 3rd technical problem, technical scheme of the present invention is:
A kind of feeding animal intestinal protective agent is as the application of animal feed additive, and the protectant addition of said feeding animal intestinal is 0.1～0.3wt% of animal feed.
Owing to adopted technique scheme, the invention has the beneficial effects as follows:
Feeding animal intestinal protective agent of the present invention is through adding growth of animal and the useful various nutritional labelings of intestinal environment; Movable and reparation provides the prescribing adequate nutrition material for intestinal cell; Balance enteron aisle epidermal cell osmotic pressure is alleviated cellular swelling, promotes the injury repair of intestinal epithelial cell; Remove oxygen radical, improve enteron aisle anti-oxidative defense system; Immune cell activated is built up resistance, and improves the body autoimmune function; Promote the beneficial bacterium growth, improve animal intestinal microecological balance and enteron aisle form, improve the intestine immunity ability.Use the present invention as animal feed additive, can substitute the antibiotics medicine fully, reach prevention and treatment animal intestinal disease, improve breeding performonce fo animals, improve the purpose of feed efficiency.
The specific embodiment
Come further to set forth the present invention below in conjunction with concrete embodiment.
Embodiment 1
With zymosan 250g, a water betaine 250g, lysozyme (500,000 IU/g) 40g; Glucose oxidase (15U/g) 100g, vitamin E (content 50%) 2.4g, vitamin B1 0.2; Vitamin B2 0.3g, vitamin B6 0.3g, nicotinic acid 0.8g; White carbon 356g mixes the back and crosses 20 mesh sieves, obtains the feeding animal intestinal protective agent of 1Kg.
Embodiment 2
With zymosan 300g, hydrochloride betaine 250g, lysozyme (500,000 IU/g) 30g; Glucose oxidase (15U/g) 120g, vitamin E (content 50%) 3.6g, vitamin B1 0.2g; Vitamin B2 0.5g, vitamin B6 0.5g, nicotinic acid 1.2g; Calcium stearate 294g crosses 20 mesh sieves and obtains the feeding animal intestinal protective agent of 1Kg behind the mixing.
Embodiment 3
With zymosan 350g, sulphonic acid betaine 300g, lysozyme (500,000 IU/g) 40g; Glucose oxidase (15U/g) 130g, vitamin E (content 50%) 3.5g, vitamin B1 0.3g; Vitamin B2 0.5g, vitamin B6 0.5g, nicotinic acid 1.2g; Calcium stearate 174g obtains the feeding animal intestinal protective agent of 1Kg behind the mixing.
Embodiment 4
With zymosan 250g, betaine 250g, lysozyme (500,000 IU/g) 20g; Glucose oxidase (15U/g) 120g, vitamin E (content 50%) 3.6g, vitamin B1 0.2g; Vitamin B2 0.5g, vitamin B6 0.5g, nicotinic acid 1.2g; Calcium stearate 354g obtains the feeding animal intestinal protective agent of 1Kg behind the mixing.
Embodiment 5
The feeding animal intestinal protective agent that embodiment 1 is prepared is as the sow feed additive, and addition is the 0.3wt% of sow feed.
Embodiment 6
The feeding animal intestinal protective agent that embodiment 2 is prepared is as chicken feed addictive, and addition is the 0.15wt% of sow feed.
Embodiment 7
The feeding animal intestinal protective agent that embodiment 3 is prepared is as additive for feed for piglets, and addition is the 0.2wt% of pig starter feed.
The comparative example 1
Adopt 270 of the weanling piglets of the about 6Kg of body weight, divide three groups: blank control group, antibiotic group and intestinal protection group, 3 parallel groups of every component, each 30 piglet of parallel group.
Blank control group: adopt complete diet pellet, do not add antibiotic and other antibiotics additives.
The antibiotic group: adopt complete diet pellet, complete diet pellet per ton adds feeding aureomycin (10%) 1.5Kg.
The intestinal protection group: adopt complete diet pellet, complete diet pellet per ton adds the feeding animal intestinal protective agent 1.5Kg that embodiment 2 prepares.
More than three groups adopt above feeding patterns to feed respectively 30 days, statistics diarrhea rate, death rate and daily gain situation are seen table 1.
Table 1
| Group | Diarrhea rate (%) | Death rate (%) | Daily gain (g) |
| Control group | 25.6±0.32 | 8.9±0.45 | 198.3±0.15 |
| The antibiotic group | 10.0±0.45 | 5.6±0.14 | 223.1±0.21 |
| The intestinal protection group | 10.3±0.21 | 5.6±0.09 | 225.6±0.32 |
The comparative example 2
Adopt 1800 of 0 age in days fryer, divide three groups: blank control group, antibiotic group and intestinal protection group, 3 parallel groups of every component, each 30 little fryer of parallel group.
Blank control group: adopt complete diet pellet, do not add antibiotic and other antibiotics additives.
The antibiotic group: adopt complete diet pellet, complete diet pellet per ton adds feeding aureomycin (10%) 1.5Kg.
The intestinal protection group: adopt complete diet pellet, complete diet pellet per ton adds the feeding animal intestinal protective agent 1.5Kg that embodiment 3 prepares.
More than three groups adopt above feeding patterns to feed for 7 weeks respectively, statistics diarrhea rate, death rate and feedstuff-meat ratio situation are seen table 2.
Table 2
| Group | Diarrhea rate (%) | Death rate (%) | Feedstuff-meat ratio |
| Control group | 13.2±0.23 | 7.3±0.14 | 3.09±0.05 |
| The antibiotic group | 4.5±0.11 | 2.0±0.17 | 2.19±0.06 |
| The intestinal protection group | 4.4±0.19 | 2.0±0.14 | 2.15±0.06 |
Can find out that from above comparative test result in feed, add after the animal intestinal protective agent of the present invention's preparation, the grice diarrhoea rate has reduced by 59.8% than blank control group, death rate has reduced by 37.1%, and daily gain has increased by 13.8%; The diarrhea rate of chick has reduced by 66.7% than blank control group, and death rate has reduced by 72.6%, and feedstuff-meat ratio has reduced 0.94.The diarrhea rate of intestinal protection group and antibiotic group, death rate, daily gain, feedstuff-meat ratio difference is not obvious even effect is superior to the antibiotic group.Prove absolutely that intestinal protection can substitute antibiotic fully, reach prevention and treatment intestines problem, improve breeding performonce fo animals, improve the purpose of feed efficiency.
Claims (9)
1. a feeding animal intestinal protective agent is characterized in that containing in the feeding animal intestinal protective agent of every 1Kg: zymosan 250～350g, betaine 250～350g, glucose oxidase 1000～2000U, lysozyme (1～2) * 10
7IU, vitamin e1 .0～2.0g, vitamin B1 0.1～0.5g, vitamin B2 0.2～0.6g, vitamin B6 0.1～0.5g and nicotinic acid 0.7～1.2g, surplus is an excipient.
2. feeding animal intestinal protective agent as claimed in claim 1 is characterized in that: mass content >=15% of said excipient in said feeding animal intestinal protective agent.
3. feeding animal intestinal protective agent as claimed in claim 1 is characterized in that: said betaine comprises a kind of or more than one the mixture in hydrochloride betaine, sulphonic acid betaine, phosphate betaine, a water betaine and the anhydrous betaine.
4. feeding animal intestinal protective agent as claimed in claim 1 is characterized in that: said excipient comprises at least a in white carbon, the calcium stearate.
5. prepare the protectant method of feeding animal intestinal as claimed in claim 1, it is characterized in that may further comprise the steps: according to containing zymosan 250～350g, betaine 250～350g, glucose oxidase 1000～2000U, lysozyme (1～2) * 10 in the feeding animal intestinal protective agent of every 1Kg
7The content ratio of the excipient of IU, vitamin e1 .0～2.0g, vitamin B1 0.1～0.5g, vitamin B2 0.2～0.6g, vitamin B6 0.1～0.5g, nicotinic acid 0.7～1.2g and surplus; Above-mentioned various raw materials are mixed, obtain feeding animal intestinal protective agent.
6. the protectant preparation method of feeding animal intestinal as claimed in claim 5 is characterized in that: mass content >=15% of said excipient in said feeding animal intestinal protective agent.
7. the protectant preparation method of feeding animal intestinal as claimed in claim 5 is characterized in that: said betaine comprises a kind of or more than one the mixture in hydrochloride betaine, sulphonic acid betaine, phosphate betaine, a water betaine and the anhydrous betaine.
8. the protectant preparation method of feeding animal intestinal as claimed in claim 5 is characterized in that: said excipient comprises at least a in white carbon, the calcium stearate.
9. feeding animal intestinal protective agent as claimed in claim 1 is as the application of animal feed additive, and the protectant addition of said feeding animal intestinal is 0.1～0.3wt% of animal feed.
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| CN201210231081.7A CN102726614B (en) | 2012-07-04 | 2012-07-04 | Feed animal intestinal tract protective agent, preparation method and application thereof |
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| CN201210231081.7A CN102726614B (en) | 2012-07-04 | 2012-07-04 | Feed animal intestinal tract protective agent, preparation method and application thereof |
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| CN102726614A true CN102726614A (en) | 2012-10-17 |
| CN102726614B CN102726614B (en) | 2014-01-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381456A (en) * | 2015-11-11 | 2016-03-09 | 镇江荣邦生物科技有限公司 | Pharmaceutical preparation for treating chicken proventriculitis |
| CN105454695A (en) * | 2016-01-25 | 2016-04-06 | 浙江艾杰斯生物科技有限公司 | Feed additive for preventing and curing porcine diarrhea |
| CN107927382A (en) * | 2017-10-30 | 2018-04-20 | 山东弘德农牧科技有限公司 | A kind of complex enzyme preparation for feeding and preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323166A (en) * | 1998-10-15 | 2001-11-21 | Dsm公司 | Antimicrobial enzymes in animal feed |
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2012
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323166A (en) * | 1998-10-15 | 2001-11-21 | Dsm公司 | Antimicrobial enzymes in animal feed |
Non-Patent Citations (3)
| Title |
|---|
| 刘宗秀，李犹平: "酵母多糖在防控畜禽疾病上的研究进展", 《北方牧业》, no. 5, 5 March 2011 (2011-03-05), pages 27 * |
| 李尚波等: "《畜禽十大高效饲料添加剂》", 30 June 2000, article "甜菜碱", pages: 220-221 * |
| 赵晓静等: "酵母多糖在养猪生产中的应用研究", 《饲料研究》, no. 10, 31 December 2011 (2011-12-31), pages 25 - 26 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381456A (en) * | 2015-11-11 | 2016-03-09 | 镇江荣邦生物科技有限公司 | Pharmaceutical preparation for treating chicken proventriculitis |
| CN105454695A (en) * | 2016-01-25 | 2016-04-06 | 浙江艾杰斯生物科技有限公司 | Feed additive for preventing and curing porcine diarrhea |
| CN107927382A (en) * | 2017-10-30 | 2018-04-20 | 山东弘德农牧科技有限公司 | A kind of complex enzyme preparation for feeding and preparation method and application |
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| CN102726614B (en) | 2014-01-22 |
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