CN106176671A - A kind of tasteless tilmicosin granule and preparation method thereof - Google Patents
A kind of tasteless tilmicosin granule and preparation method thereof Download PDFInfo
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- CN106176671A CN106176671A CN201610776399.1A CN201610776399A CN106176671A CN 106176671 A CN106176671 A CN 106176671A CN 201610776399 A CN201610776399 A CN 201610776399A CN 106176671 A CN106176671 A CN 106176671A
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Abstract
The present invention relates to a kind of tasteless tilmicosin granule and preparation method thereof, this tilmicosin granule is by tilmicosin, internal layer coating material, granulation adjuvant, outer layer coating material is prepared from, and the most every 100 parts of granules comprise tilmicosin 5～25 parts, internal layer coating material 8～40 parts, granulation adjuvant 20～80 parts, outer layer coating material 2～10 parts；Described number is mass fraction, described internal layer coating material is one or more combination of tristerin, hexadecanol, octadecanol, described granulation adjuvant is one or both combinations of magnesium stearate, carboxymethyl starch sodium, the described combination that outer layer coating material is acrylic resin, sodium lauryl sulphate.The present invention carries out secondary capsulation to tilmicosin, makes tilmicosin isolate with external environment, had both masked the bitterness of tilmicosin, and the most do not affected feedstuff palatability.
Description
Technical field
The invention belongs to veterinary drug technical field, relate to a kind of tilmicosin micro-capsule preparation, particularly to a kind of tasteless tilmicosin
Granule and preparation method thereof.
Background technology
Tilmicosin is tylosin derivant after acid hydrolysis, is semi-synthetic Macrolide animal specific antibiosis
Element, its molecular formula is C46H80N2O13, molecular weight 869.15, and tilmicosin has similar to Macrocyclolactone lactone kind medicine antibacterial
Activity is effective to gram positive bacteria and some gram negative bacterias and mycoplasma.Especially to Actinobacillus pleuropneumoniae, Bath
The specific activity of moral Salmonella, staphylococcus aureus, streptococcus pyogenes, streptococcus pneumoniae, corynebacterium pyogenes and livestock and poultry mycoplasma
Tylosin is higher.It is mainly used in clinically treating the animals such as cattle, goat, sheep, milch cow, pig, chicken by sensitive microbial sense
Infectious diseases, but owing to tilmicosin is the most bitter, and scent of, when spice feeds, on the one hand can affect palatability, the opposing party
In the face of the stomach of animal has stimulation, causing vomiting the when of serious, even some animal smells the taste of tilmicosin and just be unwilling to enter
Food, has had a strong impact on the popularization and application of tilmicosin.And most domestic Tilmicosin enteric coated granule is all by direct and auxiliary
Material mixes, it is impossible to covers the bitterness of tilmicosin and affects its therapeutic effect.CN102319181 discloses a kind of granular pattern
Animal drug be coated technique, by weighing material, soft material processed, the granulation of extrusion spheronization method, fluid bed drying, coating, polishing, flow
Change bed be dried, sieve, the step such as Product checking to prepare corpuscular animal drug, complex process, cost are high, and preparation
Grain is single coats, and its microcrystalline cellulose excipients serves as filler or binding agent, easily bites coating into pieces and has master during animal food
The bitterness of material tilmicosin, affects palatability.
Summary of the invention
It is contemplated that for the technological deficiency of existing preparation, it is provided that a kind of stable tilmicosin granule and preparation side thereof
Method, preferred by composition and proportioning, solve palatability problems, improve therapeutic effect.
For realizing above technical purpose, the present invention by the following technical solutions:
A kind of tilmicosin granule, by tilmicosin, internal layer coating material, granulation adjuvant, the preparation of outer layer coating material and
Becoming, the most every 100 parts of granules comprise tilmicosin 5～25 parts, internal layer coating material 8～40 parts, granulation adjuvant 20～80 parts, outward
Layer coating material 2～10 parts；Described number is mass fraction, described internal layer coating material be tristerin, hexadecanol,
One or more combination of octadecanol, described granulation adjuvant is magnesium stearate, the one of carboxymethyl starch sodium or two
Plant combination, the described combination that outer layer coating material is acrylic resin, sodium lauryl sulphate.
Preferably, described internal layer coating material is tristerin.
Preferably, described granulation adjuvant is magnesium stearate and the combination of carboxymethyl starch sodium two kinds.
Preferably, every 100 parts contain tilmicosin 20 parts, tristerin 30 parts, magnesium stearate 37 parts, carboxymethyl starch
5 parts of sodium, acrylic resin 6 parts, sodium lauryl sulphate 2 parts.
Preferably, every 100 parts contain tilmicosin 10 parts, tristerin 25 parts, magnesium stearate 49 parts, carboxymethyl starch
8 parts of sodium, acrylic resin 6 parts, sodium lauryl sulphate 2 parts.
Preferably, described tilmicosin grain diameter is at 20～40 mesh.
Present invention also offers the preparation method of above-mentioned tilmicosin granule, comprise the steps:
(1). tilmicosin ground floor is coated: weigh recipe quantity tilmicosin, adds molten condition at 50～85 DEG C
Internal layer coating material carries out peplos first, obtains tilmicosin mixture；
(2). tilmicosin mixture is pelletized and the second layer is coated: the tilmicosin mixture prepared to step (1) adds
Granulation adjuvant carries out pelletizing and round as a ball, during round as a ball, sprays outer layer coating material at particle surface, obtains granule (approximation
Spherical), particle diameter is 20～40 mesh；
(3). dry: pellet product step (2) obtained is dried, and obtains final finished.
The invention have the benefit that
1), the present invention tilmicosin is carried out secondary capsulation, make tilmicosin and external environment isolate, both masked for rice
Examine the bitterness of star, the most do not affect feedstuff palatability.
2), due to the characteristic of second layer enteric peplos agent acrylic resin, wrapped after tilmicosin granule in acidity
Environment does not dissolves, gradually dissolves in intestinal alkaline environment, reach the purpose of slow release, when extending the effect of tilmicosin
Between.Meanwhile, the present invention with the addition of sodium lauryl sulphate, and sodium lauryl sulphate belongs to anion surfactant, Ke Yirang
Acrylic resin is distributed on tilmicosin granule uniformly, increases the coating rate of tilmicosin.
Accompanying drawing explanation
Fig. 1 is the Drug-time curve of different tilmicosin micro-capsule preparation.
Detailed description of the invention
The detailed description of the invention of the present invention will be described in detail below.In order to avoid the most unnecessary details,
To belonging to known structure or function will not be described in detail in following example.
In addition to being defined, technology used in following example and scientific terminology have and art technology people of the present invention
The identical meanings that member is commonly understood by.Test reagent consumptive material used in following example, if no special instructions, is routine biochemistry
Reagent；Described experimental technique, if no special instructions, is conventional method；Quantitative test in following example, is respectively provided with three times
Repeat experiment, results averaged.
In order to preferably explain the present invention, below in conjunction with detailed description of the invention, the present invention will be further described.
Embodiment 1
A kind of tilmicosin granule, every 100 parts of granules comprise tilmicosin 20 parts, tristerin 30 parts, stearic acid
37 parts of magnesium, carboxymethyl starch sodium 5 parts, acrylic resin 6 parts, sodium lauryl sulphate 2 parts.
The preparation method of this tilmicosin granule, comprises the steps:
First weigh 20 parts of tilmicosins, join in 30 parts of tristerins of 80 DEG C of molten conditions, stir.To
In above-mentioned mixture add 37 parts of magnesium stearate, 5 parts of carboxymethyl starch sodium carry out pelletizing and round as a ball, during round as a ball,
The grain surface spray second layer 6 parts of acrylic resins of enteric peplos agent and the mixed solution of 2 parts of sodium lauryl sulphates, obtain near
Spheroidal granule, particle diameter is 20～40 mesh, then dries, and obtains final tilmicosin finished granule.
Embodiment 2
A kind of tilmicosin granule, every 100 parts of granules comprise tilmicosin 5 parts, hexadecanol 5 parts, octadecanol 5 parts, tristearin
65 parts of magnesium of acid, carboxymethyl starch sodium 10 parts, acrylic resin 7 parts, sodium lauryl sulphate 3 parts.
The preparation method of this tilmicosin granule, comprises the steps:
First weigh 5 parts of tilmicosins, join 5 parts of hexadecanol of 65 DEG C of molten conditions, in 5 parts of octadecanol, stir.
In above-mentioned mixture, add 65 parts of magnesium stearate, 10 parts of carboxymethyl starch sodium carry out pelletizing and round as a ball, during round as a ball,
The particle surface spray second layer 7 parts of acrylic resins of enteric peplos agent and the mixed solution of 3 parts of sodium lauryl sulphates, obtain
The granule of almost spherical, particle diameter is 20～40 mesh, then dries, and obtains final tilmicosin finished granule.
Embodiment 3
A kind of tilmicosin granule, every 100 parts of granules comprise tilmicosin 10 parts, tristerin 25 parts, stearic acid
49 parts of magnesium, carboxymethyl starch sodium 8 parts, acrylic resin 6 parts, sodium lauryl sulphate 2 parts.
The preparation method of this tilmicosin granule, comprises the steps:
First weigh 10 parts of tilmicosins, join in 25 parts of tristerins of 80 DEG C of molten conditions, stir.To
In above-mentioned mixture add 49 parts of magnesium stearate, 8 parts of carboxymethyl starch sodium carry out pelletizing and round as a ball, during round as a ball,
The grain surface spray second layer 6 parts of acrylic resins of enteric peplos agent and the mixed solution of 2 parts of sodium lauryl sulphates, obtain near
Spheroidal granule, particle diameter is 20～40 mesh, then dries, and obtains final tilmicosin finished granule.
Embodiment 4
A kind of tilmicosin granule, every 100 parts of granules comprise tilmicosin 25 parts, tristerin 40 parts, stearic acid
23 parts of magnesium, carboxymethyl starch sodium 4 parts, acrylic resin 7 parts, sodium lauryl sulphate 1 part.
The preparation method of this tilmicosin granule, comprises the steps:
First weigh 25 parts of tilmicosins, join in 40 parts of tristerins of 80 DEG C of molten conditions, stir.To
In above-mentioned mixture add 23 parts of magnesium stearate, 4 parts of carboxymethyl starch sodium carry out pelletizing and round as a ball, during round as a ball,
The grain surface spray second layer 7 parts of acrylic resins of enteric peplos agent and the mixed solution of 1 part of sodium lauryl sulphate, obtain near
Spheroidal granule, particle diameter is 20～40 mesh, then dries, and obtains final tilmicosin finished granule.
Embodiment 5
A kind of tilmicosin granule, every 100 parts of granules comprise tilmicosin 10 parts, hexadecanol 25 parts, magnesium stearate 51 parts,
Carboxymethyl starch sodium 7 parts, acrylic resin 4 parts, sodium lauryl sulphate 3 parts.
The preparation method of this tilmicosin granule, comprises the steps:
First weigh 10 parts of tilmicosins, join 25 parts of hexadecanol of 60 DEG C of molten conditions, stir.To above-mentioned mixing
Body adds 51 parts of magnesium stearate, 7 parts of carboxymethyl starch sodium carry out pelletizing and round as a ball, during round as a ball, spray at particle surface
The second layer 4 parts of acrylic resins of enteric peplos agent and the mixed solution of 3 parts of sodium lauryl sulphates, obtain almost spherical
Granule, particle diameter is 20～40 mesh, then dries, and obtains final tilmicosin finished granule.
Number described in embodiment 1-5 is mass fraction.
Test example 1 Dissolution Rate Testing (paddle method).
The adjustment before Ce Dinging carried out dissolution instrument, makes the inner bottom part 25mm ± 2mm away from stripping rotor bottom blade, takes respectively
The dissolution medium (pH=1 and pH=8 two kinds) that degassing processes, puts in each stripping rotor, labelling 1 and 2, often 3 Duplicate Samples of group,
When the temperature constant of dissolution medium is at 37 DEG C ± 0.5 DEG C, the tilmicosin granule taking homogenous quantities is placed in stripping rotor, according to molten
Out-degree rule of operation operates, timing, respectively at the identical position sample of stripping rotor after 15min, 30min, 1h, 2h,
Filter, detection level.Dissolution see table,
As can be seen from the above table, in tilmicosin granule 2h under one's belt of the present invention will not dissolution, can be quick in intestinal
Reach bacteriocidal concentration, and sustained release goes out tilmicosin in 6h, substantially prolongs the action time of tilmicosin, improve and replace
The curative effect of meter Kao Xing.
Test example 2 pharmacokinetic trial
On pig farm, Tianjin, take healthy growing and fattening pigs 12, be randomly divided into 2 groups, 1 group with tilmicosin granule of the present invention, 2
Group, with the most coated tilmicosin powder, feeds according to prevention consumption, measures examining for rice in blood in different time
Star concentration (is averaged for 6), and figure below shows the absorption characteristic of different processing technique tilmicosin.As seen from Figure 1, in phase
In the case of medication, use production method of the present invention prepare tilmicosin granule and the most wrapped tilmicosin powder phase
Ratio, concentration in pig blood and maximum retention time are all greatly improved, and medicine uptake rate is high, and slow releasing function effect is notable.
Above-described is only the preferred embodiment of the present invention, the invention is not restricted to above example.It is appreciated that this
Skilled person the most directly derive or associate other change and become
Change, within being all considered as being included in protection scope of the present invention.
Claims (7)
1. a tilmicosin granule, it is characterised in that: this tilmicosin granule, by tilmicosin, internal layer coating material, is pelletized
Adjuvant, outer layer coating material is prepared from, and the most every 100 parts of granules comprise tilmicosin 5～25 parts, internal layer coating material 8～
40 parts, granulation adjuvant 20～80 parts, outer layer coating material 2～10 parts；Described number is mass fraction, described internal layer coating material
Material is tristerin, hexadecanol, one or more combination of octadecanol, and described granulation adjuvant is stearic acid
Magnesium, one or both combinations of carboxymethyl starch sodium, described outer layer coating material is acrylic resin, sodium lauryl sulphate
Combination.
A kind of tilmicosin granule the most according to claim 1, it is characterised in that: described internal layer coating material is stearic acid
Glyceride.
A kind of tilmicosin granule the most according to claim 2, it is characterised in that: described granulation adjuvant be magnesium stearate and
The combination that carboxymethyl starch sodium is two kinds.
4. according to a kind of tilmicosin granule described in any one of claim 1-3, it is characterised in that: every 100 parts containing examining for rice
20 parts of star, tristerin 30 parts, magnesium stearate 37 parts, carboxymethyl starch sodium 5 parts, acrylic resin 6 parts, dodecyl sulfur
2 parts of sodium of acid.
5. according to a kind of tilmicosin granule described in any one of claim 1-3, it is characterised in that: every 100 parts containing examining for rice
10 parts of star, tristerin 25 parts, magnesium stearate 49 parts, carboxymethyl starch sodium 8 parts, acrylic resin 6 parts, dodecyl sulfur
2 parts of sodium of acid.
6. according to a kind of tilmicosin granule described in any one of claim 1-5, it is characterised in that: described tilmicosin granule
Particle diameter is at 20～40 mesh.
7. the preparation method of tilmicosin granule described in any one of claim 1-6, it is characterised in that: comprise the steps:
(1). tilmicosin ground floor is coated: weigh recipe quantity tilmicosin, adds the internal layer of molten condition at 50～85 DEG C
Coating material carries out peplos first, obtains tilmicosin mixture；
(2). tilmicosin mixture is pelletized and the second layer is coated: the tilmicosin mixture prepared to step (1) adds granulation
Adjuvant carries out pelletizing and round as a ball, during round as a ball, spray outer layer coating material at particle surface, obtains granule, particle diameter
It is 20～40 mesh；
(3). dry: pellet product step (2) obtained is dried, and obtains final finished.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610776399.1A CN106176671A (en) | 2016-08-30 | 2016-08-30 | A kind of tasteless tilmicosin granule and preparation method thereof |
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| CN201610776399.1A CN106176671A (en) | 2016-08-30 | 2016-08-30 | A kind of tasteless tilmicosin granule and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524473A (en) * | 2018-06-24 | 2018-09-14 | 王琴 | It is a kind of easily to absorb Tilmicosin medicament and preparation method thereof |
| CN108553450A (en) * | 2018-06-24 | 2018-09-21 | 王琴 | A kind of Tilmicosin pill and preparation method thereof |
| CN108553449A (en) * | 2018-02-14 | 2018-09-21 | 浙江万方生物科技有限公司 | A kind of taste masking sustained release Tilmicosin pre-mixing agent and preparation method thereof |
| CN108653230A (en) * | 2018-06-24 | 2018-10-16 | 王琴 | Coating type veterinary drug pill and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688220A (en) * | 2012-06-07 | 2012-09-26 | 湖州爱宝莱动物药业有限公司 | Tilmicosin micro-capsule preparation and preparation method thereof |
| CN103083281A (en) * | 2013-01-15 | 2013-05-08 | 广州格雷特生物科技有限公司 | Enteric-coated tilmicosin slow-release micro-capsule preparation and preparation method thereof |
-
2016
- 2016-08-30 CN CN201610776399.1A patent/CN106176671A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688220A (en) * | 2012-06-07 | 2012-09-26 | 湖州爱宝莱动物药业有限公司 | Tilmicosin micro-capsule preparation and preparation method thereof |
| CN103083281A (en) * | 2013-01-15 | 2013-05-08 | 广州格雷特生物科技有限公司 | Enteric-coated tilmicosin slow-release micro-capsule preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵林: "替米考星肠溶微丸的研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553449A (en) * | 2018-02-14 | 2018-09-21 | 浙江万方生物科技有限公司 | A kind of taste masking sustained release Tilmicosin pre-mixing agent and preparation method thereof |
| CN112587507A (en) * | 2018-02-14 | 2021-04-02 | 浙江万方生物科技有限公司 | Preparation method of taste-masking slow-release tilmicosin premix |
| CN113143887A (en) * | 2018-02-14 | 2021-07-23 | 浙江万方生物科技有限公司 | Preparation method of taste-masking slow-release tilmicosin premix |
| CN108524473A (en) * | 2018-06-24 | 2018-09-14 | 王琴 | It is a kind of easily to absorb Tilmicosin medicament and preparation method thereof |
| CN108553450A (en) * | 2018-06-24 | 2018-09-21 | 王琴 | A kind of Tilmicosin pill and preparation method thereof |
| CN108653230A (en) * | 2018-06-24 | 2018-10-16 | 王琴 | Coating type veterinary drug pill and preparation method thereof |
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Application publication date: 20161207 |