CN115518106A - A veterinary Chinese medicinal composition for protecting gastrointestinal tract, and its preparation method - Google Patents
A veterinary Chinese medicinal composition for protecting gastrointestinal tract, and its preparation method Download PDFInfo
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
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Abstract
The invention discloses a veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation and a preparation method thereof, the traditional Chinese medicine composition preparation takes medicated leaven and hawthorn as monarch drugs, dried orange peel and radish seed as ministerial drugs, poria cocos and pomegranate rind as adjuvant drugs, and pumpkin rind and liquorice as conductant drugs, and the synergistic cooperation effect among the monarch, ministerial, adjuvant and conductant drug substances is effectively utilized according to the pharmacology of strengthening spleen and stomach, helping digestion and regulating middle warmer, and promoting diuresis and tonifying qi, so that the effects of efficiently conditioning intestines and stomach and preventing gastrointestinal diseases are achieved; meanwhile, the effective medicinal components in the raw material medicines can be released more by carrying out targeted enzymolysis treatment, so that the utilization rate of the medicinal components in the raw material medicines is improved, and the prevention effect on gastrointestinal diseases of livestock and poultry is better.
Description
Technical Field
The invention relates to a traditional Chinese medicine preparation for livestock, in particular to a traditional Chinese medicine composition preparation for gastrointestinal tract health care for livestock and a preparation method thereof.
Background
With the intensive development of the breeding industry, economic benefits become one of the important factors restricting the breeding scale and guaranteeing the market stability, and improving the growth speed of livestock and poultry and reducing the breeding cost become the main means for improving the economic benefits of breeding. The prevention and treatment of livestock and poultry diseases are one of the main costs of cultivation, and are important breakthrough openings capable of obviously reducing the cultivation cost. In order to reduce the probability of illness of livestock and poultry, people often improve the immunity of the livestock and poultry by adding various antibiotics or traditional Chinese medicine compositions into feed, but the use of a large amount of antibiotics can not only bring serious side effects and influence the quality safety of livestock products, but also improve the breeding cost, and although the traditional Chinese medicine compositions have no side effects, the traditional Chinese medicine compositions have the defects of slow speed for preventing and treating diseases, long medication period and poor effect, or the traditional Chinese medicine compositions have the defects of high cost (good efficacy and expensive raw medicine) and are not beneficial to large-scale popularization and application in breeding.
As the gastrointestinal health and the digestion state are one of the main factors influencing the growth speed of the livestock and poultry, the dosage of the medicaments related to the gastrointestinal tract is large in the process of breeding the livestock and poultry, and the influence on the economic benefit of breeding is very obvious. When the intestines, the stomach and the digestion of the livestock and the poultry go wrong, the growth of the livestock and the poultry is influenced, the expense of corresponding treatment medicines is increased, and great economic loss is brought to farmers.
Disclosure of Invention
The invention aims to overcome the defects of poor medicinal effect and high cost of the traditional gastrointestinal tract health-care preparation for livestock and provides a gastrointestinal tract health-care traditional Chinese medicine composition preparation for livestock and a preparation method thereof; in the traditional Chinese medicine composition preparation, the medicated leaven and the hawthorn are taken as monarch drugs, the dried orange peel and the radish seed are taken as ministerial drugs, the tuckahoe and the pomegranate rind are taken as adjuvant drugs, the pumpkin rind and the liquorice are taken as conductant drugs, and the synergetic cooperation effect among the monarch, ministerial, adjuvant and conductant drug substances is effectively utilized according to the pharmacology of strengthening the spleen and stomach, promoting digestion and regulating the middle warmer, and inducing diuresis and tonifying qi, so that the effects of efficiently conditioning the intestines and stomach and preventing the gastrointestinal diseases are achieved; meanwhile, through targeted enzymolysis treatment, more effective medicinal components in the raw material medicines can be released, so that the utilization rate of the medicinal components in the raw material medicines is improved, and the prevention effect on gastrointestinal diseases of livestock and poultry is better.
In order to realize the aim, the invention provides a veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation which is prepared from the following raw materials in parts by weight: 2-4 parts of medicated leaven, 8-15 parts of hawthorn, 4-7 parts of dried orange peel, 0.3-0.8 part of radish seed, 6-12 parts of pomegranate peel, 5-8 parts of tuckahoe, 10-20 parts of pumpkin peel and 5-8 parts of liquorice.
The medicated leaven is prepared by fermenting polygonum hydropiper, sweet wormwood, almond paste, red bean and fresh xanthium sibiricum with flour or bran, has the effects of strengthening spleen and stomach, and helping digestion and removing stasis, is a monarch drug, can form a synergistic interaction effect with other raw materials under a specific dosage, has an excellent health-care effect on the intestines and stomach of livestock and poultry, can reduce the occurrence of gastrointestinal diseases, promotes the intake of nutrient components of the livestock and poultry, improves the growth speed, is easy to prepare, wide in raw material source, easy to obtain and low in price, and is a common and commonly used raw material drug; preferably, the medicated leaven is 3 parts.
The hawthorn is dry mature fruit of Crataegus pinnatifida Bunge or Crataegus pinnatifida Bunge of Rosaceae, has the effects of promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbidity and reducing blood fat, is a monarch drug, can form a synergistic interaction with the rest raw materials under a specific dosage, can improve the digestion speed of livestock and poultry on food, increase the food intake and improve the growth speed, is easy to obtain, has low price and is common and commonly used raw materials; preferably, the hawthorn is 12 parts.
The tangerine peel is dry mature pericarp of citrus reticulata blanco of Rutaceae and cultivars thereof, has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm, is a ministerial drug, can form a synergistic interaction with other raw material drugs under a specific dosage, has an excellent health-care effect on intestines and stomach, can reduce gastrointestinal diseases, increase appetite and improve growth speed, is easy to obtain, has low price, and is a common and commonly used raw material drug; preferably, the dried orange peel is 5 parts.
The radish seeds are dry mature seeds of cruciferae radish, have the effects of helping digestion, relieving distension, descending qi and reducing phlegm, are ministerial drugs, can form a synergistic effect with other raw material drugs under a specific dosage, can improve the digestion speed of livestock and poultry on food, increase the food intake and improve the growth speed, are wide in source and easy to obtain, and are common and commonly used raw material drugs; preferably, the radish seed is 0.5 part.
The pomegranate rind is the dried pericarp of pomegranate of punicaceae, has the effects of relieving diarrhea with astringents, stopping bleeding and expelling parasites, is an adjuvant drug, can form a synergistic effect with the rest raw material drugs under a specific dosage, can reduce the harm of parasites to livestock and poultry, protects the health of gastrointestinal tract, is beneficial to improving the growth speed of the livestock and poultry, has wide sources and low price, is easy to obtain, and is a common raw material drug; preferably, the pomegranate bark accounts for 10 parts.
The poria cocos is dried sclerotium of the poria cocos, which is a fungus of the family Polyporaceae, has the effects of promoting diuresis, eliminating dampness, strengthening spleen and calming heart, is an adjuvant drug, can form a synergistic interaction with other raw material drugs under a specific dosage, has a certain health-care effect on intestines and stomach of livestock, can reduce gastrointestinal diseases, promotes the discharge of harmful components of livestock and poultry, is wide in poria peel source, is easy to obtain, and is a common and commonly used raw material drug; preferably, the poria cocos is 7 parts.
The pumpkin peel is the dried peel of the fruit of Cucurbita of Cucurbitaceae, has the effects of detoxifying and protecting gastrointestinal mucosa, can form a synergistic interaction effect with other raw materials under a specific dosage as a messenger drug, can strengthen the gastrointestinal tract of livestock and poultry, can reduce gastrointestinal diseases, promotes the intake of nutrients of livestock and poultry, improves the growth speed, has wide sources, is easy to obtain, has low cost, can be used as vegetables or can be used as grains; preferably, the pumpkin peel is 15 parts.
The liquorice is the dried root and rhizome of liquorice, liquorice bloat or glycyrrhiza glabra of leguminosae, has the effects of tonifying spleen and benefiting qi, clearing heat and removing toxicity, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the drugs, can form a synergistic interaction effect with other raw material drugs under a specific dosage as a messenger drug, harmonizes the drugs and increases the drug effect, also has a certain health-care effect on intestines and stomach of livestock and poultry, and the liquorice peel has wide sources, is easy to obtain and low in cost, and is a common and common raw material drug; preferably, the liquorice is 6 parts.
Preferably, the gastrointestinal tract health care traditional Chinese medicine composition preparation for animals is prepared from the following raw materials in parts by weight: 3 parts of medicated leaven, 12 parts of hawthorn, 5 parts of dried orange peel, 0.5 part of radish seed, 10 parts of pomegranate peel, 7 parts of tuckahoe, 15 parts of pumpkin peel and 6 parts of liquorice; the optimized raw material medicines are in parts by weight, so that the synergistic effect is better, the cost is lower, and the health-care effect on the gastrointestinal tracts of livestock is better.
Wherein, preferably, the addition amount of the veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation in the feed is 0.2-0.5%; the preferable addition amount is less in dosage and lower in cost under the condition of having excellent gastrointestinal health care effect.
In order to achieve the above object, the present invention further provides a preparation method of a veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation, which comprises the following steps:
(1) Crushing the raw materials according to a formula and uniformly mixing to obtain a mixed raw material;
(2) Adding biological enzyme into the mixed raw materials, and carrying out enzymolysis treatment to obtain an enzymolysis product;
(3) Drying the enzymolysis product at low temperature to obtain the veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation.
In the step (1), preferably, the crushed particle size of the raw material medicine is 50-200 meshes; the smaller the grinding particle size, the better the release effect and the absorption effect of the effective medicinal components, but the higher the grinding cost, and the more volatile components are easy to volatilize and dissipate, so that the shelf life of the preparation is reduced, and the storage, transportation and use are not facilitated.
Wherein in the step (2), the biological enzymes are pectinase and cellulase; through the enzymolysis treatment of the biological enzyme, more medicinal components can be released, the utilization rate is higher, and the health care effect is better.
Preferably, the mass ratio of the pectinase to the cellulase in the biological enzyme is 1: 2; the preferable mass ratio is better in enzymolysis effect.
Preferably, the adding mass percentage of the biological enzyme is 0.05-0.1%; the dosage is too large, the enzymolysis is more thorough, the loss speed of volatile medicinal components is faster, the quality guarantee period is shorter, the dosage is too small, the enzymolysis effect is small, and the promotion effect on the preparation effect is small.
Wherein, in the step (2), the water content of the mixed raw materials is controlled to be 20-35% in the enzymolysis treatment process; the enzymolysis temperature is 28-32 ℃, and the enzymolysis time is 8-16h; the optimized enzymolysis condition has good enzymolysis effect, high speed and low cost.
Wherein, in the step (3), the drying temperature is 40-60 ℃, the preferable drying temperature has lower energy consumption, and part of effective medicinal components can not be damaged or lost; preferably, the dried enzymatic hydrolysate has a water content of 5-8%.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the pharmacology of strengthening spleen and stomach, promoting digestion and regulating middle warmer, inducing diuresis and replenishing qi, the medicated leaven, the hawthorn, the dried orange peel, the radish seed, the tuckahoe, the pomegranate peel, the pumpkin peel and the liquorice contained in the traditional Chinese medicine composition preparation can effectively utilize the synergistic cooperation effect of various monarch, minister, assistant and guide raw material medicines, thereby achieving the effects of efficiently regulating intestines and stomach and preventing intestines and stomach diseases.
2. The raw material medicines used in the traditional Chinese medicine composition preparation are common raw material medicines, have wide sources, low price and low production cost, can effectively improve the growth speed of livestock and poultry, can increase the economic benefit of the breeding industry, and is suitable for large-scale popularization and application.
3. In the preparation method of the traditional Chinese medicine composition preparation, more effective medicinal ingredients in the raw material medicines can be released by carrying out targeted enzymolysis treatment, so that the utilization rate of the medicinal ingredients in the raw material medicines is improved, and the traditional Chinese medicine composition preparation has a better effect of preventing gastrointestinal diseases of livestock and poultry.
Detailed Description
The present invention will be described in further detail with reference to test examples and specific embodiments. It should be understood that the scope of the above-described subject matter is not limited to the following examples, and any techniques implemented based on the disclosure of the present invention are within the scope of the present invention.
The preparation method comprises the following steps:
(1) Crushing the raw materials into 100 meshes according to a formula and uniformly mixing to obtain a mixed raw material;
(2) Adding biological enzyme (mass ratio of pectinase to cellulase is 1: 2) into the mixed raw materials at 0.05% by mass, and performing enzymolysis at 30 deg.C and 25% water content for 12h to obtain enzymolysis product;
(3) Drying the enzymolysis product at 50 deg.C to obtain Chinese medicinal composition preparation with water content of 6%.
Example (b):
comparative example:
experimental example:
1. experimental groups: the traditional Chinese medicine composition preparation prepared in the above examples 1-3 and comparative examples 1-7 is added to the same pig feed (45 parts of corn, 25 parts of soybean meal, 10 parts of water hyacinth, 3 parts of spirulina powder, 10 parts of sawdust, 1 part of vitamin complex and 2 parts of protein powder) according to the weight ratio of 0.3% to prepare the gastrointestinal tract health care pig feed.
Blank group: a pig feed;
2. raising management and index determination
The test herd was fed ad libitum and water, the feed was fed on a separate meal 3 times per day (time 7, 13, 00, 19 respectively), and the immunization program was performed according to the pig farm feeding management program. The whole test period was 30 days (pigs were 40 days old, 10 per group).
Observing and recording the occurrence frequency of diarrhea of each group of pigs in the experimental period in detail; at the same time, average feed intake (as feed) and average weight gain of the pigs during the test period were recorded.
The results are reported in the following table:
the experimental results show that the traditional Chinese medicine composition preparation prepared in the embodiments 1-3 can effectively prevent the diarrhea of pigs, has an excellent health-care effect on the intestinal tracts of the pigs, can increase the feed intake, improves the growth speed, and has a positive effect on improving the economic benefit of the breeding industry.
Claims (10)
1. A gastrointestinal tract health-care traditional Chinese medicine composition preparation for animals is characterized by comprising the following raw materials in parts by weight: the material is prepared from the following raw materials in parts by weight: 2-4 parts of medicated leaven, 8-15 parts of hawthorn, 4-7 parts of dried orange peel, 0.3-0.8 part of radish seed, 6-12 parts of pomegranate peel, 5-8 parts of poria cocos, 10-20 parts of pumpkin peel and 5-8 parts of liquorice.
2. The traditional Chinese medicine composition preparation as claimed in claim 1, wherein the medicated leaven is 3 parts.
3. The Chinese medicinal composition preparation as claimed in claim 2, wherein the hawthorn is 12 parts.
4. The traditional Chinese medicine composition preparation according to claim 3, which is prepared from the following raw materials in parts by weight: 3 parts of medicated leaven, 12 parts of hawthorn, 5 parts of dried orange peel, 0.5 part of radish seed, 10 parts of pomegranate peel, 7 parts of tuckahoe, 15 parts of pumpkin peel and 6 parts of liquorice.
5. The preparation of a Chinese medicinal composition according to any one of claims 1 to 4, wherein the preparation of a veterinary Chinese medicinal composition for gastrointestinal health care is added to the feed in an amount of 0.2 to 0.5%.
6. A method for preparing a veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation according to any one of claims 1 to 4, which is characterized by comprising the following steps:
(1) Crushing the raw materials according to a formula and uniformly mixing to obtain a mixed raw material;
(2) Adding biological enzyme into the mixed raw materials, and carrying out enzymolysis treatment to obtain an enzymolysis product;
(3) Drying the enzymolysis product at low temperature to obtain the veterinary gastrointestinal tract health-care traditional Chinese medicine composition preparation.
7. The method for preparing the Chinese medicinal composition preparation according to claim 6, wherein the biological enzymes in the step (2) are pectinase and cellulase, and the mass ratio of the pectinase to the cellulase in the biological enzymes is 1: 2.
8. The preparation method of the traditional Chinese medicine composition preparation according to claim 6, wherein the adding mass percentage of the biological enzyme in the step (2) is 0.05-0.1%.
9. The preparation method of the Chinese medicinal composition preparation according to claim 6, wherein in the step (2), the water content of the mixed raw materials is controlled to be 20-35% in the enzymolysis treatment process; the enzymolysis temperature is 28-32 deg.C, and the enzymolysis time is 8-16h.
10. The method for preparing a Chinese medicinal composition as claimed in claim 6, wherein the drying temperature in step (3) is 40-60 ℃.
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Application publication date: 20221227 |