CN1817141A - Compound plant extract for preventing avian influenza and preparation thereof - Google Patents
Compound plant extract for preventing avian influenza and preparation thereof Download PDFInfo
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- CN1817141A CN1817141A CN 200610038180 CN200610038180A CN1817141A CN 1817141 A CN1817141 A CN 1817141A CN 200610038180 CN200610038180 CN 200610038180 CN 200610038180 A CN200610038180 A CN 200610038180A CN 1817141 A CN1817141 A CN 1817141A
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Abstract
A composite vegetative liquid extract for preventing fowls' influenza is prepared from 10 plants including honeysuckle flower, wild chrysanthemum flower, albizia flower, pueraria flower, etc through extracting, concentrating and packing.
Description
Technical field
The present invention relates to the sterilization of medical science or veterinary medicine, sterilization, be meant the compound plant extract that be used for birds flu-preventing and the preparation method of a kind of trade name especially for " Qiang Pusheng ".
Background technology
Along with the continuous variation of avian influenza virus, bird flu has become the No.1 eqpidemic disease of aviculture, and particularly the bird flu of highly pathogenic in recent years H5N1 type causes large quantities of chicken death in the outburst in Asia, has caused crushing blow to aviculture, even has threatened the mankind.Though had some common disinfectantses on the domestic market at present, for example aldehyde disinfectant, chlorine-containing disinfectant and bases preparation etc., but because these disinfectants are the chemicals of synthetic, in use environment and animal body there are very strong excitant and corrosivity, what all can cause certain infringement, thereby have limited the use of these common disinfectantses.Though the Tamiflu " Tamiflu " that Switzerland Roche Holding Ag produces (Tamflu) has effective effect of certain treatment influenza, its primary raw material is the Chinese anise fruit, but " Tamiflu " be medicine for oral administration just, can not be as disinfectant to the work that carries out disinfection of environment and animal body.Therefore, it is very necessary that research and development have natural sex, noresidue, the novel Chinese herbal disinfectant that has no drug resistance is used to control avian influenza virus.
Summary of the invention
Technical problem to be solved by this invention just is to overcome the defective of existing bird flu common disinfectants, and a kind of compound plant extract and preparation method who selects for use active ingredient prescription in the natural plant extracts to be used for birds flu-preventing is provided.The compound plant extract that is used for birds flu-preventing of the present invention is made up of honeysuckle, mother chrysanthemum, trollflower, Flos Albiziae, Inula britannica chinensis, FI puerariae, butterflybush flower, plum blossom, goldenrod, tussilago, and the weight proportion of raw material is: honeysuckle 10-16 part, mother chrysanthemum 17-23 part, trollflower 6-10 part, Flos Albiziae 7-11 part, Inula britannica chinensis 10-15 part, FI puerariae 8-12 part, butterflybush flower 6-10 part, plum blossom 4-8 part, goldenrod 10-14 part, tussilago 1-3 part.The weight proportion commonly used of raw material is 13 parts of honeysuckles, 20 parts of mother chrysanthemums, 8 parts of trollflowers, 9 parts of Flos Albiziaes, 12 parts of Inula britannica chinensiss, 10 parts of FI puerariaes, 8 parts of butterflybush flowers, 6 parts in plum blossom, 12 parts of goldenrods, 2 parts of tussilagoes.Can also add oldenlandia diffusa, cordate houttuynia, affine cudweed, geranium wilfordii, polygala root, the root of large-flowered skullcap, dandelion, loguat leaf, Herba Andrographitis in the raw material, the weight proportion of adding ingredient is oldenlandia diffusa 10-16 part, cordate houttuynia 17-23 part, affine cudweed 6-10 part, geranium wilfordii 7-12 part, polygala root 10-14 part, root of large-flowered skullcap 8-12 part, dandelion 6-10 part, loguat leaf 5-7 part, Herba Andrographitis 10-16 part.The weight proportion commonly used of adding ingredient is 13 parts of oldenlandia diffusas, 20 parts of cordate houttuynias, 8 parts of affine cudweeds, 9 parts of geranium wilfordiis, 12 parts of polygala roots, 10 parts of the roots of large-flowered skullcap, 8 parts of dandelions, 6 parts of loguat leaves, 14 parts of Herba Andrographitis.
The compound plant extract that is used for birds flu-preventing of the present invention is at a large amount of investigation and experiment basis, require more than 1,000 kinds of Chinese herbal medicines are screened according to the product design function, monarch, seven human emotions compatibility, eighteen incompatibilities 18 fear scheduling theories according to traditional Chinese medicine, screening and the Chinese herbal medicine effective ingredients, the bacteriostasis that filter out extracted and verify is one by one finally determined prescription.The pharmacology situation of each component is in the prescription: (1) honeysuckle: heat-clearing and detoxifying drug, nature and flavor are sweet, cold, go into lung, stomach, the heart channel of Hang-Shaoyin, are mainly used in hot carbuncle carbuncle, have the detoxifcation carbuncle of loosing, the clearing heat and cooling blood effect, can also swell clearly make eye bright, expelling wind and cold pathogens.As " Lonicera and Forsythia ball " is exactly to be the preparation of main ingredient with the honeysuckle, is the treatment flu, because of laryngitis, stomatitis and some dermopathic good medicine.The analysis and research of modern pharmacology find that honeysuckle contains biochemical components such as inositol, wooden slippers straw colour element, inositol, saponin, tannic acid, also contain and go back protogene in a large number.Toxin to secretions such as staphylococcus, hemolytic streptococcus, typhoid bacillus, tubercle bacillus, pneumococcus has stronger inhibitory action.(2) mother chrysanthemum: wind and heat dispersing, removing toxicity for detumescence, soothing the liver broken blood.(3) trollflower: clearing heat and detoxicating function is arranged, belong to broad-spectrum antibacterial medicine, gram-positive cocci and gram-Negative bacillus are all had better action.(4) Flos Albiziae: resolving stagnation for tranquilization.Be used for confused and worried, melancholy insomnia.(5) Inula britannica chinensis: the dissolving phlegm therapeutic method to keep the adverse qi flowing downward, the soft heavily fortified point ruffian that disappears, row water preventing or arresting vomiting is antiphlogistic.(6) FI puerariae: relieving muscles to expel heat, to promote the production of body fluid, promoting eruption rises positive antidiarrheal.(7) butterflybush flower: contain flavonoids, iridoids and triterpenoid saponin etc., the heat-clearing nourishing the liver is arranged, the removing nebula effect.(8) plum blossom: contain flavonoids rutin, Quercetin and chlorogenic acid etc., can open Yu Hezhong, reduce phlegm, detoxifcation.(9) goldenrod: herb contains rutin, Kaempferol-3-rutinoside, goldenrod phenol glucoside, 2,6-dimethoxybenzoic acid benzyl ester, angelic acid-3,5-dimethoxy-4 '-acetoxyl group cinnamic ester and 2-is suitable, 8-is suitable-matricariaester.Property is put down, mildly bitter flavor, flat.Wind and heat dispersing is arranged, the function of anti-inflammation.(10) tussilago: moistening lung to lower qi is relieving cough and reducing sputum.
The main function of the composition that adds: (1) oldenlandia diffusa: have clearing heat and detoxicating, inducing diuresis to reduce edema, the function of promoting blood circulation and stopping pain.(2) cordate houttuynia: anticancer, the heat clearing and inflammation relieving of relieving internal heat, doctor's sore loose swollen, clearing damp and promoting diuresis all have stronger bacteriostasis to staphylococcus aureus, pneumococcus, Bacillus influenzae, shigella dysenteriae, tubercle bacillus, typhoid bacillus; Dermatophytes such as red mentagrophytes, trichophyton concentricum, gypsum sample pityrosporion ovale, Microsporum ferrugineum also there is bacteriostasis; The influenza virus that 1: 10 decocting liquid is cultivated human embryo kidney (HEK) simple epithelium cellular tissure of former generation has inhibitory action, also can delay its growth to echovirus.(3) affine cudweed: herb contains volatile oil, cyanidenon-4 '-glycoside, sitosterol, potassium chloride, potassium nitrate, cyanidenon.Property is put down, and it is little sweet to distinguish the flavor of.Eliminate the phlegm, cough-relieving is relievingd asthma, the effect of wind-damp dispelling.(4) geranium wilfordii: wind-damp dispelling, the network that stimulates the menstrual flow, antidiarrheal dysentery.(5) polygala root: root contains saponin(e, can get two kinds of sapogenin crystallizations after the hydrolysis, is presenegenin A and presenegenin B, and contains polygalytol, fat oil, resin etc.Have calm, anticonvulsion, eliminate the phlegm, antibacterial action.(6) root of large-flowered skullcap: heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis; Be used for damp-warm syndrome, the heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian is full, rushes down dysentery, jaundice, and the cough with lung heat, high hot polydipsia, blood-head is told nosebleed, carbuncle sore tumefacting virus.(7) dandelion: clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia; Be used for furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, heat is drenched puckery pain.(8) loguat leaf: respiratory system is had inhibitory action, antibechic, eliminate the phlegm, relieving asthma.Effect to digestive system:, remarkable increase gastrointestinal motility is arranged and promote gastric secretion and choleretic effect because of containing chlorogenic acid.Loguat leaf has antibacterial, antiinflammatory action all has inhibitory action to multiple coccus, bacillus.(9) Herba Andrographitis: contain andrographolide, neoandrographolide, 14-deoxyandrographolide, andrographolide glucoside, 14-deoxyandrographolide glucoside and flavonoids etc.Cold in nature, bitter.Have clearing heat and detoxicating, cool blood, the detumescence function.
The preparation process that is used for the compound plant extract of birds flu-preventing of the present invention comprises:
Bulk drug is chosen → is cut medicine → batching and extract → concentrates → pack
The major control condition:
Operating ambient temperature 18-30 ℃, humidity 30-70%;
Drinking water addition during extraction: the drinking water (w/w) of ten times of amounts of crude drug;
Extract the control temperature: 100 ℃;
Extraction time: 2 hours;
Extract mixing speed: 24 rev/mins;
Concentrate: heating evaporation is concentrated into 1/3 of original volume;
Concentrate speed of agitator: 20 rev/mins.
The concrete steps that are used for the compound plant extract preparation process of birds flu-preventing are:
(1) bulk drug selection, cleaning are manually sorted out the impurity in the crude drug; To put in the service sink through the natural plants crude drug of selection and wash, drain away the water in the clean rearmounted container with drinking water.
(2) cut medicine, ratio of rhizome medicinal material is cut into sheet, operating ambient temperature 18-30 ℃, humidity 30-70% with medicine cutter.
(3) batching and extraction, according to each component of prescription proportioning weighing, 18-30 ℃ of operating ambient temperature of batching, humidity 30-70%; The drinking water that in extractor, adds about total amount 1/3 earlier, under agitation add load weighted natural vegetable Chinese herbal medicine, then with drinking water to total amount, the total addition of drinking water is ten times (w/w) of crude drug, and 24 rev/mins of speeds of agitator are opened the steam valve extraction that heats up, 100 ℃ of control temperature, keep extracting after 2 hours and finish, filter extract, and extract is delivered to concentration tank.
(4) concentrate, the extract in the concentration tank is heated to boils, keep fluidized state, make extract be concentrated into 1/3 of original volume, add and the isopyknic vinegar of concentrate, stir.
(5) packing adopts liquid subpackage that liquid filling machine obtains (4) in the PE bottle.
In the aforesaid operations process, after finishing, the wash process can crude drug moisture be dried by baking oven.Should not can carry out coarse crushing with boulder crusher at the crude drug of medicine cutter chopping to part simultaneously, coarse crushing finishes and rescreens fine powder.After concentration process is finished, also concentrate can be added in the Agitation Tank, and the purified water of passing through the two-pass reverse osmosis acquisition that is incorporated as concentrate weight 1/3 is carried out diluted mixture, 2/3 the vinegar that is incorporated as concentrate weight again is as preservative, speed of agitator with 40r/min stirred 15 minutes, carried out packing then.Adopt the compound plant extract yield of this preparation technology method to reach more than 20%.
The compound plant extract end product quality reaches following specification requirement:
| Sequence number | Project | Index |
| 1 | The pH value | 2.5-4.5 |
| 2 | Alkaloid | ≥0.2％ |
| 3 | Polysaccharide | ≥0.1％ |
The compound plant extract that advantage of the present invention just is to adopt the present invention to be used for birds flu-preventing is as the disinfectant for animals of environment and animal body, because active ingredients such as the polysaccharide that contains in the compound plant extract, alkaloid, plant acid, camellia phenol have the effect of killing influenza virus, bacteria growing inhibiting breeding, prevention animal epidemic, can reach effect and requirement fully to environment and animal body sterilization.The compound plant extract component that is used for birds flu-preventing of the present invention all adopts natural vegetable Chinese herbal medicine, the advantage that have natural sex, noresidue, has no drug resistance has thoroughly solved excitant and corrosivity adverse consequences that existing chemicals disinfectant produces in disinfecting process.Simple, the easy operating of compound plant extract preparation technology that is used for birds flu-preventing of the present invention, and low production cost, therefore compound plant extract and the preparation method who is used for birds flu-preventing of the present invention has the vast market promotion prospect.
Description of drawings
The present invention is described further below in conjunction with accompanying drawing.
Fig. 1 is the flow diagram that is used for the compound plant extract preparation technology of birds flu-preventing of the present invention.
With reference to Fig. 1, as figure, inspection, selection and cleaning operation unit constitute bulk drug selection, matting, cut medicine operating unit formation and cut pharmaceutical worker's preface, weighing and extraction operating unit constitute batching and abstraction process, the concentration operation unit constitutes enrichment process, and preparation, filtration and drinking water two-pass reverse osmosis, purified water filter operation unit constitute the diluted mixture operation, and can, spiral cover, labeling, packing, finished product is to be checked and finished product in-stockroom operation unit constitutes packaging process.Water extraction is adopted in extraction to active ingredient, is solvent with water.Add natural vegetable Chinese herbal medicine in extractor after, boiled 2 hours, leach extract and be concentrated into 1/3 of original volume to concentration tank, be sub-packed in the container by filling apparatus then, the concentration tank operating pressure is a normal pressure.
Embodiment
Below be one embodiment of the present of invention, the actual use of the present invention is not limited to embodiment.
Embodiment 1, is used for the compound plant extract and the preparation method of birds flu-preventing
Adopt the compound plant extract preparation technology method that is used for birds flu-preventing of the present invention to prepare compound plant extract, production capacity 600kg/ split run.
Compound plant extract is made up of honeysuckle, mother chrysanthemum, trollflower, Flos Albiziae, Inula britannica chinensis, FI puerariae, butterflybush flower, plum blossom, goldenrod, tussilago.The raw material weight proportioning is honeysuckle 13kg, mother chrysanthemum 20kg, trollflower 8kg, Flos Albiziae 9kg, Inula britannica chinensis 12kg, FI puerariae 10kg, butterflybush flower 8kg, plum blossom 6kg, goldenrod 12kg, tussilago 2kg.
Main production equipments
| Sequence number | Device name | Model specification | Quantity |
| 1 2 3 4 5 5 | Reciprocating type medicine cutter electronic platform scale extractor storage tank scraper-type vacuum concentrator flexible package punch unit | WQY240 3m 3 3m 3 1m 3 YG | 112111 cover |
The major control condition
Operating ambient temperature 18-30 ℃, humidity 30-70%;
Extract the total addition 1000kg of drinking water, extract 100 ℃ of control temperature,
Extraction time: water boil 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of speeds of agitator, concentration time 120 minutes;
Vinegar addition: 50kg.
Concrete preparation process:
(1) bulk drug selection, cleaning are manually sorted out the impurity in the crude drug; To put in the service sink through the natural plants crude drug of selection and wash, drain away the water in the clean rearmounted container with drinking water.
(2) cut medicine, ratio of rhizome medicinal material is cut into sheet, 24 ℃ of operating ambient temperatures, humidity 40-45% with the reciprocating type medicine cutter of WQY240.
(3) batching and extraction, according to a prescription proportioning weighing component, 24 ℃ of operating ambient temperatures of batching, humidity 40-45%; The drinking water that in extractor, adds about total amount 1/3 earlier, under agitation add load weighted natural vegetable Chinese herbal medicine then with drinking water to total amount, the total addition of drinking water is that 10 times of medicinal material weight reach 1000kg, speed of agitator 24r/min, open the steam valve extraction that heats up, 100 ℃ of control temperature keep temperature to extract end after 2 hours, filter extract, and send in the concentration tank.
(4) in the concentration tank chuck by steam, heat to boiling, concentration tank agitator speed 20r/min kept about 120 minutes, to the concentrate volume to stoste 1/3, the collection concentrate is to containers for future use.
(5) diluted mixture, concentrate is added in the Agitation Tank, and add 150kg and carry out diluted mixture by the purified water that two-pass reverse osmosis obtains, the vinegar that adds 50kg again is as preservative, stir 15 minutes, speed of agitator 40r/min, 24 ℃ of operating ambient temperatures, humidity 40-45%.
(6) packing adopts YG type liquid meter packing unit, with the liquid subpackage after the preparation in the PE bottle.
The compound plant extract end product quality reaches following specification requirement:
PH value: 2.5; Alkaloid 〉=0.25%; Polyoses content 〉=0.1%.
The birds flu-preventing compound plant extract that uses above method to produce detects through Harbin Veterinary Medicine Inst., China Academy of Agriculture, and its dilution of 1: 20 to 1: 80 has 100% killing action to the H5N1 subtype avian influenza virus.
Embodiment 2, are used for the compound plant extract and the preparation method of birds flu-preventing
Adopt the compound plant extract preparation technology method that is used for birds flu-preventing of the present invention to prepare compound plant extract, production capacity is with embodiment 1.
The compound plant extract raw material has also added oldenlandia diffusa, cordate houttuynia, affine cudweed, geranium wilfordii, polygala root except that comprising honeysuckle, mother chrysanthemum, trollflower, Flos Albiziae, Inula britannica chinensis, FI puerariae, butterflybush flower, plum blossom, goldenrod, tussilago.The raw material weight proportioning is honeysuckle 13kg, mother chrysanthemum 20kg, trollflower 8kg, Flos Albiziae 9kg, Inula britannica chinensis 12kg, FI puerariae 10kg, butterflybush flower 8kg, plum blossom 6kg, goldenrod 12kg, tussilago 2kg, oldenlandia diffusa 13kg, cordate houttuynia 20kg, affine cudweed 8kg, geranium wilfordii 9kg, polygala root 12kg, the root of large-flowered skullcap 10, dandelion 8, loguat leaf 6, Herba Andrographitis 14.
Main production equipments
| Sequence number | Device name | Model specification | Quantity |
| 1 | Reciprocating type medicine cutter | WQY240 | 1 |
| 2 2 3 4 5 5 | Roughpulverizer electronic platform scale extractor storage tank scraper-type vacuum concentrator flexible package punch unit | CSJ 3m 3 3m 3 1m 3 YG | 112111 cover |
The major control condition
Operating ambient temperature 18-30 ℃, humidity 30-70%;
Extracting the total addition of drinking water is 1600kg, extracts 100 ℃ of control temperature,
Extraction time: water boil 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of speeds of agitator, concentration time 180 minutes;
Vinegar addition: 580kg.
Concrete preparation process:
(1) bulk drug selection, cleaning are manually sorted out the impurity in the crude drug; To put in the service sink through the natural plants crude drug of selection and wash, drain away the water in the clean rearmounted container with drinking water.
(2) cut medicine, ratio of rhizome medicinal material is cut into sheet, 18 ℃ of operating ambient temperatures, humidity 30-35% with the reciprocating type medicine cutter of WQY240.
(3) batching and extraction, according to each component of prescription proportioning weighing, 18 ℃ of operating ambient temperatures of batching, humidity 30-35%; The drinking water that in extractor, adds about total amount 1/3 earlier, under agitation add load weighted natural vegetable Chinese herbal medicine, then with drinking water to total amount 1600kg, the total addition of drinking water is 10 times of medicinal material weight, and speed of agitator 24r/min opens the steam valve extraction that heats up, 100 ℃ of control temperature, keep temperature to extract end after 2 hours, filter extract, and send in the concentration tank.
(4) feed steam in the concentration tank chuck, heat to boiling, concentration tank agitator speed 20r/min kept 180 minutes, to the concentrate volume to stoste 1/2, collect concentrate to containers for future use.
(5) diluted mixture adds concentrate in the Agitation Tank, and adding and the equiponderant vinegar of concentrate stir 15 minutes, speed of agitator 40r/min, 18 ℃ of operating ambient temperatures, humidity 30-35% as preservative again.
(6) packing adopts YG liquid meter packing unit, with the liquid subpackage after the preparation in the PE bottle.
The compound plant extract end product quality reaches following specification requirement:
PH value: 4.5; Alkaloid 〉=0.35%: polyoses content 〉=0.12%
Compound plant extract with this law preparation carries out the clinical disinfection test through animal medicine institute of Agricultural University Of Nanjing in the somewhere, Shandong, it is efficient to reach 100%.
Embodiment 3, are used for the compound plant extract and the preparation method of birds flu-preventing
Adopt the compound plant extract preparation technology method that is used for birds flu-preventing of the present invention to prepare compound plant extract, production capacity is with embodiment 1.
Compound plant extract is made up of honeysuckle, mother chrysanthemum, trollflower, Flos Albiziae, Inula britannica chinensis, FI puerariae, butterflybush flower, plum blossom, goldenrod, tussilago.The raw material weight proportioning is honeysuckle 10kg, mother chrysanthemum 17kg, trollflower 6kg, Flos Albiziae 7kg, Inula britannica chinensis 10kg, FI puerariae 8kg, butterflybush flower 6kg, plum blossom 4kg, goldenrod 10kg, tussilago 1kg, oldenlandia diffusa 10kg, cordate houttuynia 17kg, affine cudweed 6kg, geranium wilfordii 7kg, polygala root 10kg, root of large-flowered skullcap 8kg, dandelion 6kg, loguat leaf 5kg, Herba Andrographitis 10kg.
Main production equipments
| Sequence number | Device name | Model specification | Quantity |
| 1 2 3 4 5 5 | Reciprocating type medicine cutter electronic platform scale extractor storage tank scraper-type vacuum concentrator flexible package punch unit | WQY240 3m 3 3m 3 1m 3 YG | 112111 cover |
The major control condition
Operating ambient temperature 18-30 ℃, humidity 30-70%;
Extracting the total addition of drinking water is 1000kg, extracts 100 ℃ of control temperature,
Extraction time: water boil 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of speeds of agitator, concentration time 180 minutes;
Vinegar addition: 50kg.
Concrete preparation process:
(1) bulk drug selection, cleaning are manually sorted out the impurity in the crude drug; To put in the service sink through the natural plants crude drug of selection and wash, drain away the water in the clean rearmounted container with drinking water.
(2) cut medicine, ratio of rhizome medicinal material is cut into sheet, 28 ℃ of operating ambient temperatures, humidity 50-55% with the reciprocating type medicine cutter of WQY240.
(3) batching and extraction, according to a prescription proportioning weighing component, 28 ℃ of operating ambient temperatures of batching, humidity 50-55%; The drinking water that in extractor, adds about total amount 1/3 earlier, under agitation add load weighted natural vegetable Chinese herbal medicine then with drinking water to total amount 1000kg, the total addition of drinking water is 10 times of medicinal material weight, speed of agitator 24r/min, open the steam valve extraction that heats up, 100 ℃ of control temperature keep temperature to extract end after 2 hours, filter extract, and send in the concentration tank.
(4) in the concentration tank chuck by steam, heat to boiling, concentration tank agitator speed 20r/min kept 180 minutes, to the concentrate volume to stoste 1/3, the collection concentrate is to containers for future use.
(5) diluted mixture, concentrate is added in the Agitation Tank, and 1/3 the purified water that two-pass reverse osmosis obtains of passing through that is incorporated as concentrate weight is carried out diluted mixture, the vinegar that adds 50kg again is as preservative, stir 15 minutes, speed of agitator 40r/min, 28 ℃ of operating ambient temperatures, humidity 50-55%.
(6) packing adopts YG liquid meter packing unit, with the liquid subpackage after the preparation in the PE bottle.
The compound plant extract end product quality reaches following specification requirement:
PH value: 3; Alkaloid 〉=0.28%; Polyoses content 〉=0.18%.
The birds flu-preventing compound plant extract that uses above method to produce, detect through Harbin Veterinary Medicine Inst., China Academy of Agriculture, its dilution of 1: 20 to 1: 80 has 100% killing action to the H5N1 subtype avian influenza virus, and maximal non-toxic dosage is 1: 5.
Embodiment 4, are used for the compound plant extract and the preparation method of birds flu-preventing
Adopt the compound plant extract preparation technology method that is used for birds flu-preventing of the present invention to prepare compound plant extract, production capacity is with embodiment 1.
Compound plant extract is made up of honeysuckle, mother chrysanthemum, trollflower, Flos Albiziae, Inula britannica chinensis, FI puerariae, butterflybush flower, plum blossom, goldenrod, tussilago.The raw material weight proportioning is honeysuckle 16kg, mother chrysanthemum 23kg, trollflower 10kg, Flos Albiziae 11kg, Inula britannica chinensis 15kg, FI puerariae 12kg, butterflybush flower 10kg, plum blossom 8kg, goldenrod 14kg, tussilago 3kg, oldenlandia diffusa 16kg, cordate houttuynia 23kg, affine cudweed 10kg, geranium wilfordii 12kg, polygala root 14kg, root of large-flowered skullcap 12kg, dandelion 10kg, loguat leaf 7kg, Herba Andrographitis 16kg.
Main production equipments
| Sequence number | Device name | Model specification | Quantity |
| 1 2 3 4 5 5 | Reciprocating type medicine cutter electronic platform scale extractor storage tank scraper-type vacuum concentrator flexible package punch unit | WQY240 3m 3 3m 3 1m 3 YG | 112111 cover |
The major control condition
Operating ambient temperature 18-30 ℃, humidity 30-70%;
Extracting the total addition of drinking water is 1000kg, extracts 100 ℃ of control temperature,
Extraction time: water boil 2 hours, 24 rev/mins of speeds of agitator;
Concentrate 20 rev/mins of speeds of agitator, concentration time 180 minutes;
Vinegar addition: 50kg.
Concrete preparation process:
(1) bulk drug selection, cleaning are manually sorted out the impurity in the crude drug; To put in the service sink through the natural plants crude drug of selection and wash, drain away the water in the clean rearmounted container with drinking water.
(2) cut medicine, ratio of rhizome medicinal material is cut into sheet, 28 ℃ of operating ambient temperatures, humidity 50-55% with the reciprocating type medicine cutter of WQY240.
(3) batching and extraction, according to a prescription proportioning weighing component, 28 ℃ of operating ambient temperatures of batching, humidity 50-55%; The drinking water that in extractor, adds about total amount 1/3 earlier, under agitation add load weighted natural vegetable Chinese herbal medicine then with drinking water to total amount 1000kg, the total addition of drinking water is 10 times of medicinal material weight, speed of agitator 24r/min, open the steam valve extraction that heats up, 100 ℃ of control temperature keep temperature to extract end after 2 hours, filter extract, and send in the concentration tank.
(4) in the concentration tank chuck by steam, heat to boiling, concentration tank agitator speed 20r/min kept 180 minutes, to the concentrate volume to stoste 1/3, the collection concentrate is to containers for future use.
(5) diluted mixture, concentrate is added in the Agitation Tank, and 1/3 the purified water that two-pass reverse osmosis obtains of passing through that is incorporated as concentrate weight is carried out diluted mixture, the vinegar that adds 50kg again is as preservative, stir 15 minutes, speed of agitator 40r/min, 28 ℃ of operating ambient temperatures, humidity 50-55%.
(6) packing adopts YG liquid meter packing unit, with the liquid subpackage after the preparation in the PE bottle.
The compound plant extract end product quality reaches following specification requirement:
PH value: 3.5; Alkaloid 〉=0.22%; Polyoses content 〉=0.16%
The birds flu-preventing compound plant extract that uses above method to produce, detect through Harbin Veterinary Medicine Inst., China Academy of Agriculture, its dilution of 1: 20 to 1: 80 has 100% killing action to the H5N1 subtype avian influenza virus, and maximal non-toxic dosage is 1: 5.
Claims (8)
1, a kind of compound plant extract that is used for birds flu-preventing, it is characterized in that being made up of honeysuckle, mother chrysanthemum, trollflower, Flos Albiziae, Inula britannica chinensis, FI puerariae, butterflybush flower, plum blossom, goldenrod, tussilago, the weight proportion of raw material is: honeysuckle 10-16 part, mother chrysanthemum 17-23 part, trollflower 6-10 part, Flos Albiziae 7-11 part, Inula britannica chinensis 10-15 part, FI puerariae 8-12 part, butterflybush flower 6-10 part, plum blossom 4-8 part, goldenrod 10-14 part, tussilago 1-3 part.
2, the compound plant extract of birds flu-preventing according to claim 1, the weight proportion that it is characterized in that raw material are 13 parts of honeysuckles, 20 parts of mother chrysanthemums, 8 parts of trollflowers, 9 parts of Flos Albiziaes, 12 parts of Inula britannica chinensiss, 10 parts of FI puerariaes, 8 parts of butterflybush flowers, 6 parts in plum blossom, 12 parts of goldenrods, 2 parts of tussilagoes.
3, the compound plant extract of birds flu-preventing according to claim 1 and 2, it is characterized in that also adding in the raw material oldenlandia diffusa, cordate houttuynia, affine cudweed, geranium wilfordii, polygala root, the root of large-flowered skullcap, dandelion, loguat leaf, Herba Andrographitis, the weight proportion of adding ingredient is oldenlandia diffusa 10-16 part, cordate houttuynia 17-23 part, affine cudweed 6-10 part, geranium wilfordii 7-12 part, polygala root 10-14 part, root of large-flowered skullcap 8-12 part, dandelion 6-10 part, loguat leaf 5-7 part, Herba Andrographitis 10-16 part.
4, the compound plant extract of birds flu-preventing according to claim 3, the weight proportion that it is characterized in that adding ingredient are 13 parts of oldenlandia diffusas, 20 parts of cordate houttuynias, 8 parts of affine cudweeds, 9 parts of geranium wilfordiis, 12 parts of polygala roots, 10 parts of the roots of large-flowered skullcap, 8 parts of dandelions, 6 parts of loguat leaves, 14 parts of Herba Andrographitis.
5, the compound plant extract of birds flu-preventing according to claim 1 is characterized in that the compound plant extract preparation process comprises: bulk drug is chosen → is cut medicine → batching and extract → concentrates → pack; Major control condition: operating ambient temperature 18-30 ℃, humidity 30-70%, the drinking water addition is the drinking water (w/w) of ten times of amounts of crude drug during extraction, extracting the control temperature is 100 ℃, extraction time is 2 hours, extracting mixing speed is 24 rev/mins, concentrates to be controlled to be heating evaporation and to be concentrated into 1/3 of original volume, and concentrated speed of agitator is 20 rev/mins.
6, the compound plant extract of birds flu-preventing according to claim 1 is characterized in that the compound plant extract end product quality reaches: 1, pH value 2.5-4.5,2, alkaloid 〉=0.2%, 3, polyoses content 〉=0.1%.
7, the compound plant extract of birds flu-preventing according to claim 5 is characterized in that compound plant extract preparation process extract concentrates the back and adds and the isopyknic vinegar of concentrate, stirs.
8, the compound plant extract of birds flu-preventing according to claim 5, it is characterized in that after concentration process is finished, concentrate being added in the Agitation Tank, and the purified water of passing through the two-pass reverse osmosis acquisition that is incorporated as concentrate weight 1/3 is carried out diluted mixture, 2/3 the vinegar that is incorporated as concentrate weight again is as preservative, speed of agitator with 40r/min stirred 15 minutes, carried out packing then.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100381808A CN100364414C (en) | 2006-02-06 | 2006-02-06 | Compound plant extract for preventing avian influenza and preparation thereof |
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| CNB2006100381808A CN100364414C (en) | 2006-02-06 | 2006-02-06 | Compound plant extract for preventing avian influenza and preparation thereof |
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| CN1817141A true CN1817141A (en) | 2006-08-16 |
| CN100364414C CN100364414C (en) | 2008-01-30 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010502655A (en) * | 2006-09-07 | 2010-01-28 | 士▲栄▼ 楼 | Application of Solidago radish in the preparation of drugs for antiviral treatment and prevention |
| CN102813721A (en) * | 2012-08-29 | 2012-12-12 | 郑州后羿制药有限公司 | Pharmaceutical composition for livestock heat clearing and livestock detoxifying and preparation method thereof |
| CN102934714A (en) * | 2012-12-10 | 2013-02-20 | 张敏 | Prescription of linden Zen tea |
| JP5864010B1 (en) * | 2014-09-17 | 2016-02-17 | 株式会社理研テクノシステム | Manufacturing method of mineral functional water |
| CN105432678A (en) * | 2015-11-20 | 2016-03-30 | 陈启福 | Henhouse disease prevention disinfectant powder and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309305C (en) * | 2003-04-29 | 2007-04-11 | 上海家化联合股份有限公司 | Chinese herbal medicine air disinfectant |
| CN100337651C (en) * | 2005-03-15 | 2007-09-19 | 华南农业大学 | Chinese medicine composition for preventing bird flu |
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2006
- 2006-02-06 CN CNB2006100381808A patent/CN100364414C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010502655A (en) * | 2006-09-07 | 2010-01-28 | 士▲栄▼ 楼 | Application of Solidago radish in the preparation of drugs for antiviral treatment and prevention |
| CN102813721A (en) * | 2012-08-29 | 2012-12-12 | 郑州后羿制药有限公司 | Pharmaceutical composition for livestock heat clearing and livestock detoxifying and preparation method thereof |
| CN102813721B (en) * | 2012-08-29 | 2014-06-11 | 郑州后羿制药有限公司 | Pharmaceutical composition for livestock heat clearing and livestock detoxifying and preparation method thereof |
| CN102934714A (en) * | 2012-12-10 | 2013-02-20 | 张敏 | Prescription of linden Zen tea |
| JP5864010B1 (en) * | 2014-09-17 | 2016-02-17 | 株式会社理研テクノシステム | Manufacturing method of mineral functional water |
| JP2016065035A (en) * | 2014-09-17 | 2016-04-28 | 株式会社理研テクノシステム | Manufacturing method of mineral functional water |
| CN105432678A (en) * | 2015-11-20 | 2016-03-30 | 陈启福 | Henhouse disease prevention disinfectant powder and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100364414C (en) | 2008-01-30 |
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Assignee: Zhenjiang Tianhe Biotechnology Co., Ltd. Assignor: Yangzhong Mule Pharmacy Group Co., Ltd. Contract fulfillment period: 2008.7.30 to 2015.7.29 contract change Contract record no.: 2008320000300 Denomination of invention: Compound plant extract for preventing avian influenza and preparation thereof Granted publication date: 20080130 License type: Exclusive license Record date: 2008.9.23 |
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Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.7.30 TO 2015.7.29 Name of requester: ZHENJIANG TIANHE BIOLOGY TECHNOLOGY CO., LTD. Effective date: 20080923 |
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Granted publication date: 20080130 Termination date: 20120206 |