CN1256133C - Antifatigue Chinese medicine composition and its prepn process - Google Patents
Antifatigue Chinese medicine composition and its prepn process Download PDFInfo
- Publication number
- CN1256133C CN1256133C CN 03136905 CN03136905A CN1256133C CN 1256133 C CN1256133 C CN 1256133C CN 03136905 CN03136905 CN 03136905 CN 03136905 A CN03136905 A CN 03136905A CN 1256133 C CN1256133 C CN 1256133C
- Authority
- CN
- China
- Prior art keywords
- weight portion
- chinese medicine
- radix
- medicine composition
- active component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The present invention discloses a Chinese medicine composition with fatigue resistance function, which is composed of the following principal raw materials as components, or composed of the following principal raw material water extract or alcohol extract as active components, and addition agents which can be accepted by pharmacy: 50 to 500 parts by weight of American ginseng, 50 to 500 parts by weight of ginseng, 50 to 1000 parts by weight of epimedium herb, 100 to 1000 parts by weight of solomonseal rhizome and 50 to 500 parts by weight of danshen root. The present invention also discloses a preparation method of the Chinese medicinal composition. The Chinese medicinal composition of the present invention uses raw materials which accord with the requirements of health food raw materials of the national health department, has the advantages of reasonable component proportion, and simple and effective preparation method, has the functions of fatigue resistance and immunoregulation. The effective ingredients of the present invention can be easily absorbed by human bodies.
Description
Technical field
The present invention relates to Chinese medicine and health food, specifically relate to a kind of Chinese medicine composition and preparation method thereof with anti-fatigue effect.
Background technology
Chinese medicine such as Radix Panacis Quinquefolii, Radix Ginseng has resisting fatigue, health-care effect generally is familiar with by people, but simple ginseng class preparation effect is single, price is high, and it is not ideal enough to be suitable for little, the actual resisting fatigue effect of crowd's scope.Publication number is please disclose a kind of antifatigue Chinese medicine composition in the patent of invention of CN1296833A, Radix Ginseng, Radix Notoginseng and solid preparation acceptable auxiliary by micronizing are formed, wherein in described compositions the weight ratio of Radix Ginseng and Radix Notoginseng between 1: 5 to 2: 1.The preparation of this Chinese medicine composition, after Radix Ginseng and Radix Notoginseng are carried out micronizing respectively, obtain the micropowder that particle diameter is not more than 80 μ m, the Radix Ginseng and the Radix Notoginseng micropowder that obtain were mixed by weight 1: 5 to 2: 1, add the solid preparation acceptable auxiliary, adopt the conventional preparation method of solid preparation to make.Animal experiment shows that the Chinese medicine composition of this invention has the obvious anti-fatigue effect.Because the human body individual variation is bigger, the Chinese medicinal powder preparation is unfavorable for the absorption of human body active ingredient.
Summary of the invention
The invention provides that a kind of human body is easy to absorb, is suitable for that the range of age is wide, resisting fatigue obvious results Chinese medicine composition and prepare the method for said composition.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii, have strengthening by means of tonics, the yin nourishing of nourishing blood, the effect of invigorating the spleen and benefiting QI, and have biologic activity widely, main effective ingredient is chemical compound and trace element such as Saponin, polysaccharide, is the article that can be used for health food that Ministry of Public Health is determined.Carry out the experiment of antifatigue effect with mice swimming with a load attached to the body method, Radix Panacis Quinquefolii group mice swimming time obviously prolongs, and very obvious with the matched group comparing difference, the result shows that Radix Panacis Quinquefolii has antifatigue effect.In recent years, be applied to immunity of organism regulated to Radix Panacis Quinquefolii extract and with other drug matchings and study, prove that Radix Panacis Quinquefolii Saponin has immunological enhancement and in certain density dosage range, can obviously strengthen the cytoactive of the natural killer cell and the lymphokineactivation killer cell of tumour patient.
Radix Ginseng is the dry root of Araliaceae Radix Ginseng, be China's tradition rare Chinese medicine, has the strengthening by means of tonics effect, the energy strongly invigorating primordial QI, effect such as the mind calming and mentality promoting, spleen invigorating, QI invigorating are arranged, promote the production of body fluid, mainly containing effective ingredient such as polysaccharide such as Saponin, each seed amino acid, vitamin, is the article that can be used for health food that Ministry of Public Health is determined.Carry out mice anti-anoxia ability, the experiment of swimming with a load attached to the body resisting fatigue with the ginsenoside, the result proves that mice time-to-live and swimming time obviously prolong, and shows that Radix Ginseng has antifatigue effect.Effect to Radix Ginseng total saponins is studied, the result shows that Radix Ginseng total saponins can reduce mice brain and myocardium lactic acid content under the severe depletion of oxygen situation, the reduction of cardiac muscle CAMP/CGMP ratio shows that Radix Ginseng total saponins can improve the energy metabolism when being organized in anoxia in the time of recovering anoxia.
Herba Epimedii is the dry aerial parts (stem, leaf) of Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, pubescence Herba Epimedii, Wushan Herba Epimedii or Korea's Herba Epimedii, having effects such as invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, heart tonifying power, is the article that can be used for health food that Ministry of Public Health is determined.Herba Epimedii is traditional kidney invigorating and YANG supporting article, has many-sided pharmacological action.Research both at home and abroad it is generally acknowledged that flavone compound is the main pharmacological component of Herba Epimedii.Carry out the experiment of mice swimming with a load attached to the body resisting fatigue with Herba Epimedii extract, the mice swimming time obviously prolongs, and the result shows that this extract has antifatigue effect, and observes and can improve the mice hypoxia-bearing capability.The promotion immune function experiment result of Herba Epimedii total flavones shows that Herba Epimedii total flavones has good immunologic enhancement, and the obvious allomeric function of enhancing body neuroendocrine network immunity.
Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati, Rhizoma Polygonati or Polygonatum cyrtonema Hua.Have the spleen reinforcing lung moistening, the effect of supplementing QI and nourishing YIN, be Ministry of Public Health determine be food be again the article of medicine.Rhizoma Polygonati is familiar with by people very early, and " Japan hanako materia medica " record " is mended five kinds of strain and seven kinds of impairment, helped muscles and bones, end famine, cold-resistant summer-heat, strengthening the spleen stomach, profit cardiopulmonary." Rhizoma Polygonati extracting solution tests through mouse stomach, demonstration can significantly reduce the heart, the liver lipid peroxidation thing generates, and increases superoxide dismutase, glutathione peroxidase activity and blood SOD vigor, and has immunological enhancement.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Effect with blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind is the article that can be used for health food that Ministry of Public Health is determined.Have obvious resisting fatigue through testing its extract, reduce blood lactic acid, increase the function of motion bleeding from anus red eggs Pseudobulbus Bletillae (Rhizoma Bletillae) pulmonary ventilation, and have the effect of protecting cellular immune function.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum, has the effect of nourishing liver and kidney, replenishing vital essence to improve eyesight, be Ministry of Public Health determine be food be again the article of medicine.Fructus Lycii is top grade as nourishing always since ancient times, and the multiple function of human body is had regulating action.Through test of mice airtight anoxia and the experiment of swimming resisting fatigue, the result shows: Fructus Lycii extract can obviously prolong the mice time-to-live and continue, power exhausts the swimming matter of right and wrong, thereby shows that Fructus Lycii can effectively improve hypoxia-bearing capability and the anti-fatigue ability of mice.Through the Fructus Lycii immunomodulating being done experiment research, prove that Fructus Lycii has good immunological enhancement.
Pericarpium Citri tangerinae is the dry mature fruit of Rutaceae Fructus Citri tangerinae and variety thereof, have be good for the stomach, wind dispelling, preventing or arresting vomiting, end oh aid digestion, eliminate the phlegm, loose bronchial smooth muscle, function of gallbladder promoting, boost, effect such as antiulcer, be Ministry of Public Health determine be food be again the article of medicine.Confirm that after deliberation Pericarpium Citri tangerinae all has remarkable increase effect to guinea pig serum lysozyme content, serum coagulation antibody titre, painstaking effort T lymphocyte E Flos Rosae Rugosae formation rate, illustrates that Pericarpium Citri tangerinae all has certain facilitation to humoral immunization and cellular immunization.
Semen Coicis is the dry mature kernal of grass Semen Coicis, has functions such as spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Be Ministry of Public Health determine be food be again the article of medicine.According to reports, all show anticomplementary activity, have immunization from Semen Coicis hot water extract isolating neutral polysaccharide glucosan mixture and part acidic polysaccharose.
A kind of antifatigue Chinese medicine composition is made or by the water of following raw materials according and/or alcohol extract is made active component and pharmaceutically acceptable additives are made: Radix Panacis Quinquefolii 50--500 weight portion, Radix Ginseng 50--500 weight portion, Herba Epimedii 50--1000 weight portion, Rhizoma Polygonati 100--1000 weight portion, Radix Salviae Miltiorrhizae 50--500 weight portion by following raw materials according.
The preferable parts by weight of raw materials ratio of above-mentioned Chinese medicine composition is: Radix Panacis Quinquefolii is the 100--300 weight portion, and Radix Ginseng is the 100--200 weight portion, and Herba Epimedii 450--650 weight portion, Rhizoma Polygonati are the 350--550 weight portion, and Radix Salviae Miltiorrhizae is the 100--300 weight portion.
Can add some flavor accessory drugss in the above-mentioned Chinese medicine composition, Fructus Lycii and Pericarpium Citri tangerinae and Semen Coicis, the addition of Fructus Lycii is the 100--200 weight portion, and the addition of Pericarpium Citri tangerinae is the 100--200 weight portion, and the addition of Semen Coicis is the 100--200 weight portion.
Chinese medicine composition of the present invention routinely Chinese formulated products or water (with)/or alcohol extract the preparation method that obtains active component and can be made into various dosage form, as make electuary, decoction, capsule or tablet, and can use various excipient of the prior art.But for improving drug effect, Chinese medicine composition optimization of the present invention adopts following preparation method:
A kind of preparation method of antifatigue Chinese medicine composition the steps include:
(e) take by weighing the following traditional Chinese medicines material as raw material: Radix Panacis Quinquefolii 50--500 weight portion, Radix Ginseng 50--500 weight portion, Herba Epimedii 50--1000 weight portion, Rhizoma Polygonati 100--1000 weight portion, Radix Salviae Miltiorrhizae 50--500 weight portion.
(f) with part Radix Panacis Quinquefolii, Radix Ginseng section, Rhizoma Polygonati is concocted the back section, and the Radix Salviae Miltiorrhizae section mixes with Herba Epimedii, obtains decoction liquor after decocting boils, and decoction liquor adds alcohol extraction, and extracting solution reclaims alcohol, obtains active component I after concentrating; Remaining Radix Panacis Quinquefolii, Radix Ginseng are pulverized, and I mixes with active component, and vacuum drying becomes dry product; Or
(g) with Radix Panacis Quinquefolii, Radix Ginseng section, Rhizoma Polygonati is concocted the section back and is mixed, and alcohol or water reflux, extract, get extracting solution and make active component II; Radix Salviae Miltiorrhizae cleaning section mixes after the Herba Epimedii selection, and decocting gets decoction liquor after boiling filtration, and decoction liquor adds alcohol extraction after concentrating, and extracting solution is made active component III, and active component II and active component III are merged concentrated back recovery alcohol, and vacuum drying becomes dry product.
(d) will sterilize behind dry product pulverizing, the sieving to obtain fine powder, add additives and make various dosage forms.
Wherein in step (b) or also can add the Fructus Lycii of 100--200 weight portion and/or the Pericarpium Citri tangerinae of 100--200 weight portion and/or the Semen Coicis of 100--200 weight portion (c) and make active component I or active component II;
Additives described in the step (d) are magnesium stearate, make tablet behind dry product and the magnesium stearate mix homogeneously.Additives described in the step (d) are soybean oil, make soft capsule behind dry product and the soybean oil mix homogeneously.
Chinese medicine composition of the present invention is raw materials used all to meet the requirement of health ministry healthy food material, and reasonable mixture ratio of components, preparation method are simply effective, and its active ingredient easily is absorbed by the body, and has resisting fatigue, immunoregulation effect.
The specific embodiment
Embodiment 1:
Take by weighing Radix Panacis Quinquefolii 220 grams, Radix Ginseng 150 grams, it is partially sliced to get one, and Rhizoma Polygonati 450 grams are concocted section, Radix Salviae Miltiorrhizae 220 gram sections, and Herba Epimedii 600 grams mix.Mixture adds water and decocts twice for 7 times, each 1 hour, the decoction liquor after the filtration merged, and normal pressure concentrates the back and adds edible ethanol, get its supernatant after staticly settling as extracting solution, with extracting solution reclaim under reduced pressure ethanol and concentrated, get fluid extract, remaining Radix Panacis Quinquefolii, Radix Ginseng are pulverized, fine powder mixes with above-mentioned fluid extract, become dry product at 60 ℃ of vacuum dryings, dry product is pulverized the system granule, and make tablet after an amount of magnesium stearate is mixed.
Embodiment 2:
Take by weighing Radix Panacis Quinquefolii 50 grams, Radix Ginseng 200 gram sections, Rhizoma Polygonati 500 restrains process of preparing Chinese medicine section back to be mixed, and the edible alcohol solution hot reflux with 70% each 1 hour, gets extracting solution.Take by weighing Radix Salviae Miltiorrhizae 50 gram cleaning sections, Herba Epimedii 600 restrains chooses the back mixing, adds to get decoction liquor after 7 times in water decocts filtration in 2 hours, and the concentrated down back adding of decoction liquor normal pressure edible ethanol is got its supernatant as extracting solution after staticly settling; After two extracting solution merge were concentrated, reclaim under reduced pressure ethanol became dry product at 60 ℃ of vacuum dryings, will dry product pulverizes, sterilized behind the sieving to obtain fine powder, and the soybean oil that adds about one times of amount is made soft capsule.
Embodiment 3:
Take by weighing Radix Panacis Quinquefolii 100 grams, Radix Ginseng 150 gram sections, Rhizoma Polygonati 650 restrains process of preparing Chinese medicine section back to be mixed, and the edible alcohol solution hot reflux with 70% each 1 hour, gets extracting solution.Take by weighing Radix Salviae Miltiorrhizae 200 gram cleaning sections, Herba Epimedii 400 restrains chooses the back mixing, adds to get decoction liquor after 7 times in water decocts filtration in 2 hours, and the concentrated down back adding of decoction liquor normal pressure edible ethanol is got its supernatant as extracting solution after staticly settling; After two extracting solution merge were concentrated, reclaim under reduced pressure ethanol became dry product at 60 ℃ of vacuum dryings, will dry product pulverizes, sterilized behind the sieving to obtain fine powder, and made tablet after an amount of magnesium stearate is mixed.
Embodiment 4:
Take by weighing Radix Panacis Quinquefolii 220 grams, Radix Ginseng 250 gram sections, Rhizoma Polygonati 850 grams, Radix Salviae Miltiorrhizae 200 grams, Herba Epimedii 200 grams, Fructus Lycii 100 grams, preparation technology makes soft capsule with embodiment 2.
Embodiment 5:
Take by weighing Radix Panacis Quinquefolii 300 grams, Radix Ginseng 380 gram sections, Rhizoma Polygonati 300 grams, Radix Salviae Miltiorrhizae 300 grams, Herba Epimedii 800 grams, preparation technology makes soft capsule with embodiment 2.
Embodiment 6:
Take by weighing Radix Panacis Quinquefolii 560 grams, Radix Ginseng 300 gram sections, Rhizoma Polygonati 1000 grams, Radix Salviae Miltiorrhizae 100 grams, Herba Epimedii 150 grams, Pericarpium Citri tangerinae 100 grams, preparation technology makes tablet with embodiment 1.
Embodiment 7:
Take by weighing Radix Panacis Quinquefolii 100 grams, Radix Ginseng 50 gram sections, Rhizoma Polygonati 320 grams, Radix Salviae Miltiorrhizae 50 grams, Herba Epimedii 1000 grams, Semen Coicis 100 grams, preparation technology makes tablet with embodiment 1.
Embodiment 8:
Take by weighing Radix Panacis Quinquefolii 500 gram, Radix Ginseng 50 gram sections, Rhizoma Polygonati 250 grams are concocted section, mix Fructus Lycii 130 gram selection backs, and the edible alcohol solution hot reflux with 70% each 1 hour, gets extracting solution.Take by weighing Radix Salviae Miltiorrhizae 50 gram cleaning sections, Herba Epimedii 800 restrains chooses the back mixing, adds to get decoction liquor after 7 times in water decocts filtration in 2 hours, and the concentrated down back adding of decoction liquor normal pressure edible ethanol is got its supernatant as extracting solution after staticly settling; After two extracting solution merge were concentrated, reclaim under reduced pressure ethanol became dry product at 60 ℃ of vacuum dryings, and dry product is pulverized, sterilized behind the sieving to obtain fine powder, made electuary.
Embodiment 9:
Take by weighing Radix Panacis Quinquefolii 50 grams, Radix Ginseng 50 gram sections, Rhizoma Polygonati 550 restrains process of preparing Chinese medicine section back to be mixed, and the edible alcohol solution hot reflux with 70% each 1 hour, gets extracting solution.Take by weighing Radix Salviae Miltiorrhizae 50 and restrain the cleaning section, Herba Epimedii 620 grams, Pericarpium Citri tangerinae 100 mix after restraining and choosing, and add to get decoction liquor after 7 times in water decocts filtration in 2 hours, concentrate adding edible ethanol in back under the decoction liquor normal pressure, get its supernatant after staticly settling as extracting solution; After two extracting solution merge were concentrated, reclaim under reduced pressure ethanol became dry product at 60 ℃ of vacuum dryings, will dry product pulverizes, sterilized behind the sieving to obtain fine powder, added conventional excipients and made tablet.
Embodiment 10:
Take by weighing Radix Panacis Quinquefolii 220 gram, Radix Ginseng 150 gram sections, Rhizoma Polygonati 440 grams are concocted section, mix Fructus Lycii 100 gram selection backs, and the edible alcohol solution hot reflux with 70% each 1 hour, gets extracting solution.Take by weighing Radix Salviae Miltiorrhizae 220 grams and clean section, mix Herba Epimedii 590 grams, Pericarpium Citri tangerinae 100 grams, Semen Coicis 100 gram selection backs, get decoction liquor after adding 7 times of decoctions of water filtration in 2 hours, adding edible ethanol after the decoction liquor normal pressure concentrates is down got its supernatant as extracting solution after staticly settling; After two extracting solution merge were concentrated, reclaim under reduced pressure ethanol became dry product at 60 ℃ of vacuum dryings, will dry product pulverizes, sterilized behind the sieving to obtain fine powder, and the soybean oil that adds about one times of amount is made soft capsule.
Embodiment 11:
Take by weighing Radix Panacis Quinquefolii 450 gram, Radix Ginseng 450 gram sections, Rhizoma Polygonati 100 grams are concocted section, mix Fructus Lycii 100 gram selection backs, and the edible alcohol solution hot reflux with 70% each 1 hour, gets extracting solution.Take by weighing Radix Salviae Miltiorrhizae 50 grams and clean section, mix Herba Epimedii 50 grams, Pericarpium Citri tangerinae 150 grams, Semen Coicis 150 gram selection backs, get decoction liquor after adding 7 times of decoctions of water filtration in 2 hours, adding edible ethanol after the decoction liquor normal pressure concentrates is down got its supernatant as extracting solution after staticly settling; After two extracting solution merge were concentrated, reclaim under reduced pressure ethanol became dry product at 60 ℃ of vacuum dryings, will dry product pulverizes, sterilized behind the sieving to obtain fine powder, and the soybean oil that adds about one times of amount is made soft capsule.The soft capsule that embodiment 10 is made carries out every index test, and the result is as follows:
One, the toxicity check detects according to GB-15193-94 " toxicological evaluation of food safety procedure and method " through the Zhejiang Academy of Medical Sciences, detects conclusion and is:
1. acute toxicity: to the large and small Mus per os of male and female LD
50All, belong to non-toxic type greater than 24.5 (21.5) g/kg body weight.
2. micronucleus test: negative to PCEMNR micronucleus test testing result.
3. mouse sperm deformity test: mouse sperm deformity test testing result is negative.
4.Ames test: the Salmonella reversion test testing result is negative.
The short-term per os try touch tried thing to the toxic action of rat establish 2.9,5.7, three dosage groups of 11.4g/kg body weight (be equivalent to approximately human body recommended amounts 25,50,100 times).30 days feeding trials of rat are not seen the overt toxicity reaction, indexs such as its growth promoter to rat, hemogram, blood biochemistry and dirty body compare there is no obvious influence, rat gross anatomy, histological observation result also be there is no obvious harmful effect, and drawing its action-less dose is the 11.4g/kg body weight.
Two, the health food function assessment is estimated through Jiangsu Prov. Disease Preventing and Controlling Center and is tested according to 1996 " the health food function assessment assessment process and the methods of inspection "
1. continuous 30 days per os of anti-fatigue test ICR mice are irritated stomach and are given, dosage is respectively 283,566 (be equivalent to be grown up per kg body weight per day recommended intake 10 times) 1700mg/kgb.w., and other establishes solvent control group (oil), and irritate the stomach amount and be 10ml/kgb.w.The result is:
Difference (P＞0.05) that there are no significant when (1) respectively organizing mice body weight experiment initial stage and experiment end is tried thing animal is not had obvious ill effect.
(2) swimming with a load attached to the body test: the middle and high dosage group of the sample mice swimming with a load attached to the body time all prolongs than matched group, and wherein middle dosage group is compared tool significant difference (P＜0.05) with the solvent control group, and the swimming with a load attached to the body test is positive.
(3) hepatic glycogen is measured: each dosage group Mouse Liver glycogen content of sample raises than matched group, and wherein middle dosage group has significant difference (P＜0.05).
(4) blood lactic acid is measured: three the time point blood lactic acid area under curve in the middle and high dosage group of sample mouse movement front and back are all less than matched group, and middle dosage group has significant difference (P＜0.05).
(5) serum urea is measured: serum BUN content is lower than matched group behind each dosage group mouse movement, wherein low dose group tool significant difference (P＜0.05).
According to health food function assessment evaluation criterion, the present invention has antifatigue effect.
2. immunoregulation effect test
(1) sample is to the influence of the weight of animals before and after the experiment: per os every day 1700,566 (per kg body weight per day that is equivalent to be grown up is according to 10 times of recommended intake) and 283mg/kg/d soft capsule 30d, respectively tried weightening finish of agent amount group mice and matched group there was no significant difference (P＞0.05) after the experiment.
(2) sample is to the influence of internal organs/body weight ratio: per os every day 1700,566 (per kg body weight per day that is equivalent to be grown up is according to 10 times of recommended intake) and 283mg/kg/d soft capsule 30d, compare with negative control group, each organizes thymus/body ratio, spleen/body ratio no difference of science of statistics (P＞0.05).
(3) cellular immune function test: the tardy paraphilia reaction of the inductive mice of dinitrofluorobenzene (DNFB) (DTH), per os every day 1700,566 and 283mg/kg/d soft capsule 30d, the mice auricle swelling degree all is higher than matched group, and dose-response relationship is arranged, each dosage group all has notable statistics difference, and (P＜0.05=, prompting the present invention can strengthen the mouse cell immunologic function.
(4) humoral immune function test: per os every day 1700,566 and 283mg/kg/d soft capsule 30d, each organizes mice serum half hemolysis value (HC
50) all be higher than the contrast class value, and raise with the dosage increase, middle and high dosage group has significant difference (P＜0.05, P＜0.01), points out middle and high dosage group to strengthen the humoral immune function of mice.
(5) monokaryon-macrophage function test: mice carbon clearance test: per os every day 1700,566 and 283mg/kg/d soft capsule 30d, each monokaryon-macrophage phagocytic index of organizing mice all is higher than negative control group, and dose-response relationship arranged, high dose group has and has significant difference (P＜0.01), and the prompting high dose group has the effect of the monokaryon-macrophage phagocytic function that strengthens mice.
According to health food function assessment evaluation criterion, the present invention has immunoregulation effect.
Three, functional component is identified through the Zhejiang Academy of Medical Sciences according to Q/HQYT221-2002, the Pharmacopoeia of the People's Republic of China 2000 editions, it is 106-110mg that the every 100g of detection the present invention contains total flavones (in icariine), and total Saponin (in the ginsenoside) is 812-812mg.
Four, drug-testing detects stimulant, anesthetis, beta blocker, diuretic and the steroid hormone class medicine that sample of the present invention is not found International Olympic Committee's regulation forbidding in 2000 through national analeptic and sport nutrition testing research center.
Claims (7)
1. antifatigue Chinese medicine composition is made or by the water of following raw materials according and/or alcohol extract is made active component and pharmaceutically acceptable additives are made: Radix Panacis Quinquefolii 50--500 weight portion, Radix Ginseng 50--500 weight portion, Herba Epimedii 50--1000 weight portion, Rhizoma Polygonati 100--1000 weight portion, Radix Salviae Miltiorrhizae 50--500 weight portion by following raw materials according.
2. a kind of antifatigue Chinese medicine composition according to claim 1, it is characterized in that: the parts by weight of raw materials ratio in the described Chinese medicine compound is: Radix Panacis Quinquefolii is the 100--300 weight portion, Radix Ginseng is the 100--200 weight portion, Herba Epimedii 450--650 weight portion, Rhizoma Polygonati is the 350--550 weight portion, and Radix Salviae Miltiorrhizae is the 100--300 weight portion.
3. a kind of antifatigue Chinese medicine composition according to claim 1 and 2 is characterized in that: also can add a kind of in Fructus Lycii, Pericarpium Citri tangerinae, the Semen Coicis or several in the described Chinese medicine composition; Wherein the addition of Fructus Lycii is the 100--200 weight portion, and the addition of Pericarpium Citri tangerinae is the 100--200 weight portion, and the addition of Semen Coicis is the 100--200 weight portion.
4. the preparation method of an antifatigue Chinese medicine composition the steps include:
(a) take by weighing the following traditional Chinese medicines material as raw material: Radix Panacis Quinquefolii 50--500 weight portion, Radix Ginseng 50--500 weight portion, Herba Epimedii 50--1000 weight portion, Rhizoma Polygonati 100--1000 weight portion, Radix Salviae Miltiorrhizae 50--500 weight portion.
(b) with part Radix Panacis Quinquefolii, Radix Ginseng section, Rhizoma Polygonati is concocted the back section, the Radix Salviae Miltiorrhizae section, above-mentioned decoction pieces mixes with Herba Epimedii, obtains decoction liquor after decocting with water, decoction liquor adds alcohol extraction, extracting solution reclaims alcohol, obtains active component I after concentrating, and remaining Radix Panacis Quinquefolii, Radix Ginseng are pulverized, I mixes with active component, and vacuum drying becomes dry product; Or
(c) with Radix Panacis Quinquefolii, Radix Ginseng section, Rhizoma Polygonati is concocted the section back and is mixed, alcohol or water reflux, extract, get extracting solution and make active component II, Radix Salviae Miltiorrhizae cleaning section, mix Herba Epimedii selection back, and decocting gets decoction liquor after boiling filtration, decoction liquor adds alcohol extraction after concentrating, extracting solution is made active component III, and active component II and active component III are merged concentrated back recovery alcohol, and vacuum drying becomes dry product.
(d) will sterilize behind dry product pulverizing, the sieving to obtain fine powder, add additives and make various dosage forms.
5. the preparation method of a kind of antifatigue Chinese medicine composition according to claim 4, it is characterized in that: wherein also can add Fructus Lycii 100--200 weight portion and/or 100--200 weight portion Pericarpium Citri tangerinae and/or 100--200 weight portion Semen Coicis, make active component I or II in step (b) or (c).
6. the preparation method of a kind of antifatigue Chinese medicine composition according to claim 4 is characterized in that: the additives described in the step (d) are magnesium stearate, make tablet behind dry product and the magnesium stearate mix homogeneously.
7. the preparation method of a kind of antifatigue Chinese medicine composition according to claim 4 is characterized in that: the additives described in the step (d) are soybean oil, make soft capsule behind dry product and the soybean oil mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03136905 CN1256133C (en) | 2003-05-25 | 2003-05-25 | Antifatigue Chinese medicine composition and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03136905 CN1256133C (en) | 2003-05-25 | 2003-05-25 | Antifatigue Chinese medicine composition and its prepn process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1548143A CN1548143A (en) | 2004-11-24 |
| CN1256133C true CN1256133C (en) | 2006-05-17 |
Family
ID=34323449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03136905 Expired - Fee Related CN1256133C (en) | 2003-05-25 | 2003-05-25 | Antifatigue Chinese medicine composition and its prepn process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1256133C (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773606B (en) * | 2010-03-15 | 2011-11-30 | 武汉代代木生物科技有限公司 | Preparation capable of nursing essence, replenishing qi, refreshing spirit and balancing yin and yang and preparation method thereof |
| CN102090630B (en) * | 2010-12-07 | 2013-04-03 | 荣基泰实业（深圳）有限公司 | Health-care product for enhancing antioxidation of human bodies and preparation method thereof |
| CN102302138B (en) * | 2011-05-13 | 2013-01-30 | 范圣刚 | Anti-fatigue health-care food and preparation method thereof |
| CN102613570A (en) * | 2012-04-20 | 2012-08-01 | 海燕翔 | Polygonatum- and Asiatic pennywort herb-containing functional food for enhancing immunity |
| CN103211219B (en) * | 2013-04-25 | 2014-08-20 | 福建永生活力生物工程有限公司 | Health food for relieving physical fatigue and preparation method thereof |
| CN103404847B (en) * | 2013-07-04 | 2015-02-25 | 甘肃亚兰药业有限公司 | Antifatigue healthcare composition and preparation method thereof |
| CN103549415B (en) * | 2013-10-24 | 2015-04-29 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
| CN104547270B (en) * | 2015-01-29 | 2018-10-19 | 四川绿叶制药股份有限公司 | It is a kind of to raise negative and positive, the drug of QI invigorating and blood or health-care food composition and its preparation method and application |
| CN107349291A (en) * | 2017-08-23 | 2017-11-17 | 深圳太太药业有限公司 | A kind of composition with antifatigue effect and preparation method thereof |
| CN107594525A (en) * | 2017-09-25 | 2018-01-19 | 浙江达因生物科技有限公司 | A kind of natural plant extracts, natural galenical and natural plant composition with anti-fatigue health-caring function |
| CN115944688B (en) * | 2023-02-08 | 2024-02-06 | 云南中医药大学 | Traditional Chinese medicine composition, preparation and application for relieving fatigue |
-
2003
- 2003-05-25 CN CN 03136905 patent/CN1256133C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1548143A (en) | 2004-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101181351B (en) | Chinese medicine composition for resisting tiredness and reinforcing immune as well as method of making the same | |
| CN1186070C (en) | Medicine composition for treating impotence and its prepn | |
| CN101513437A (en) | Antifatigue Chinese pharmaceutical composition and preparation method thereof | |
| CN1762236A (en) | Health-caring product capable of increasing human immunity and its preparation method | |
| CN1256133C (en) | Antifatigue Chinese medicine composition and its prepn process | |
| CN101062080A (en) | Medicinal composition for relieving fatigue and preparing process thereof | |
| CN1709469A (en) | Ginseng-astragalus dispersion tablet formulation, and its preparing process | |
| CN103933346A (en) | Blood-glucose-reducing composition and preparation method thereof | |
| CN101947296A (en) | Chinese medicine composition for treating diabetes | |
| CN1069542C (en) | Medicine for treating chronic hepatism and its preparing process | |
| CN100336537C (en) | Chinese medicinal composition for antifatigue and increasing immune power and its preparation method | |
| CN1245173C (en) | Medicine composition for treating liver fibrillation and liver cirrhosis and its prepn process | |
| CN1256967C (en) | Health-preserving liver-protecting drug and method for making same | |
| CN103705578B (en) | There is blood fat reducing and Chinese medicine preparation suppressing blood glucose rising effect and preparation method thereof | |
| CN100558349C (en) | Ginseng-astragalus capsule formulation and preparation technology thereof | |
| CN1611232A (en) | Medicinal composition with main effect of antifatigue, radioresistance and melancholia-resistance and its preparing method | |
| CN102078600B (en) | Anti-cancer compound ganoderma composition, application thereof and pharmaceutical composition containing same | |
| CN111671792B (en) | Traditional Chinese medicine composition for preventing and treating liver injury and preparation method thereof | |
| CN1692938A (en) | Compound traditional Chinese medicine for improving eyesight and its prepn. method | |
| CN104998085A (en) | Chinese herbal compound composition capable of enhancing immune function and preparation method thereof | |
| CN1903276A (en) | Medicinal composition for treating hepatitis B | |
| CN1186042C (en) | Chinese medicine composition for curing AIDS and its preparation mehtod | |
| CN1973850A (en) | Medicine composition for treating allergic rhinitis and its prepn process | |
| CN1296090C (en) | Papaya activated fiber biological preparation | |
| CN1279094A (en) | Oral medicine 'Feishu' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060517 Termination date: 20190525 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |