CN1186042C - Chinese medicine composition for curing AIDS and its preparation mehtod - Google Patents
Chinese medicine composition for curing AIDS and its preparation mehtod Download PDFInfo
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- CN1186042C CN1186042C CNB011449519A CN01144951A CN1186042C CN 1186042 C CN1186042 C CN 1186042C CN B011449519 A CNB011449519 A CN B011449519A CN 01144951 A CN01144951 A CN 01144951A CN 1186042 C CN1186042 C CN 1186042C
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Abstract
The present invention discloses a Chinese medicine composition for treating AIDS and a preparation method thereof, which belongs to medical configuration articles containing Chinese medicine material. The Chinese medicine composition is prepared from astragalus root, caragana arborescens, dried tangerine peel, atractylis lancea, english walnut fruit septum, Chinese date, red glossy ganoderma, ginseng and crystal sugar through twice decoction, the materials are filtered, filtered solutions are combined, fine powder of tuckahoe, cordyceps and saute white atractylodes rhizome is added, and a concentrated solution is made into powder through spray drying after low-temperature reduced-pressure distillation and concentration. The Chinese medicine composition is a true natural medicine which has significant curative effect and no side effect and can restore organism immunity damaged by AIDS viruses and effectively inhibit the AIDS viruses through identification of simulation experiments of animals and clinic treatment verification of AIDS patients; the present invention has significant curative effect through treatment verification of 241 clinic AIDS examples and patients with AIDS relevant disease symptoms, and the total effective rate reaches 95.8%; the present invention has no side effect when taken for a long term and has the advantages of high safety and reliability.
Description
Technical field
The invention belongs to the medical configuration product that contain the Chinese medicine material, particularly a kind of Chinese medicine composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof.
Background technology
Acquired immune deficiency syndrome (AIDS) is a kind of day after tomorrow of an acquired immune deficiency syndrome (AIDS), on very long medical history, does not also have and can so shake the whole world, and causes various countries' common concern, and drops into the disease that a large amount of human and material resources and financial resources are prevented and treated.
Treated the medicine of acquired immune deficiency syndrome (AIDS) in the past,, belonged to nucleoside medicine, had the similar pharmacological action of single antiviral, toxicity was in various degree all arranged, especially to the toxicity of bone marrow as AZT, ddc, ddi, d4T, 3TC etc.The medicine that is used for the treatment of acquired immune deficiency syndrome (AIDS) at present, it is limited generally to have curative effect, costs an arm and a leg, and toxic and side effects is big, is easy to generate chemical sproof shortcoming.
The application Chinese medicine and pharmacy is prevented and treated acquired immune deficiency syndrome (AIDS) and is also caused extensive concern, has the various components of better effects and the preparation of processing method and comes out one after another.
Chinese patent 1183298 discloses " a kind of capsule for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof ", and this capsule is chosen Herba Epimedii, Rhizoma Curcumae, Rhizoma Osmundae, Radix Et Rhizoma Rhei, the Radix Stemonae, Artemisia anethoicles Mattf, Radix Platycodonis, Herba Houttuyniae, Chinese juniper beach wormwood, Fructus Tsaoko, Cordyceps, calcium carbonate, allicin, the new element of Radix Glycyrrhizae etc. and is prepared from.
Chinese patent 1207323 discloses " a kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof ", it mainly by Hedyotidis Diffusae, Aloe, Rhizoma Polygoni Cuspidati, Indigo Naturalis, Radix Sophorae Tonkinensis, fragrant-flowered garlic seed, Ganoderma, Flos Lonicerae, Rhizoma Smilacis Glabrae, Radix Scutellariae, Radix Ginseng, Radix Glycyrrhizae, Bulbus Allii, Fructus Caricae, etc. Chinese medicine form.
Chinese patent 1181255 discloses " a kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS) ", and it is Semen Strychni (processed), Pyritum, Scorpio, Scolopendra, Sanguis Draxonis, Radix Trichosanthis, Fin Mustetus manazo, berberine to be concocted grind into powder, the full decocting extracting juice of calabash courd, after add starch and make pill.
That Chinese patent 1122236 discloses is a kind of " medicine of treatment acquired immune deficiency syndrome (AIDS) and preparation method thereof ", be adopt Cacumen Securinegae Suffruticosae, Sanguis Draxonis, the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Cortex Acanthopancis, Radix Polygoni Multiflori, Fructus Jujubae, Caulis Spatholobi, Fructus Rosae Laevigatae, Fructus Trichosanthis shell, the Radix Pulsatillae, Radix Scutellariae, Radix Isatidis, Fructus Gleditsia rice, etc. Chinese crude drug make.
1159330 of Chinese patents disclose a kind of " Chinese medicine ointment for AIDS ", and it is made by Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae Preparata, the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Ah foot, the Cortex Eucommiae, Radix Dipsaci, Fructus Corni, Fructus Lycii, Fructus Rubi, Rhizoma Alismatis, tween, sodium benzoate, crystal sugar.
Summary of the invention
Prior art medicine toxicity, side effect is big in order to solve for this Chinese medicine, the inapparent technical problem of curative effect and a kind of Chinese medicine composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof is provided.
This Chinese medicine is made by following raw materials in weight portion:
Radix Ginseng 10-30 part Radix Astragali 20-60 part tree chicken 10-30 part
Pericarpium Citri Reticulatae 15-45 part Atractylodes lancea (Thunb.) DC. 20-60 part Poria 15-45 part
Partition in Fructus Juglandis 6-20 part Fructus Jujubae 50-100 part
Cordyceps (Cordyceps) 15-60 part
Red ganoderma 15-60 part Rhizoma Atractylodis Macrocephalae (parched) 20-80 part crystal sugar 20-60 part.
This Chinese medicine is made by following raw materials in weight portion:
30 parts of 30 parts of trees of 30 parts of Radixs Astragali of Radix Ginseng chickens
15 parts in 20 parts of Poria of 10 parts of Atractylodes lancea (Thunb.) DC. of Pericarpium Citri Reticulatae
50 parts in 6 portions of Fructus Jujubaes of Partition in Fructus Juglandis
Cordyceps (Cordyceps) 15-60 part
30 parts in 20 portions of crystal sugar of 20 parts of Rhizoma Atractylodis Macrocephalae (parched)s of red ganoderma.
This preparation method of Chinese medicine is:
Take by weighing Radix Astragali 20-60 part, tree chicken 10-30 part, Radix Ginseng 10-30 part, Fructus Jujubae 50-100 part, Pericarpium Citri Reticulatae 15-45 part, Atractylodes lancea (Thunb.) DC. 20-60 part, Partition in Fructus Juglandis 6-20 part, Cordyceps (Cordyceps) 20-60 part, red ganoderma 15-60 part, Radix Ginseng 10-30 part, Fructus Jujubae 50-100 part by weight, clean up back cold water soak 1-2 hour, boil with the immersion decocting, for the first time amount of water is 6 times of above component, decoct Radix Ginseng, Fructus Jujubae earlier, 1.5-2 hour, adding other components and crystal sugar 20-60 part, decocted 30-45 minute; Decocting liquid is standby through vacuum filtration; The water that medicinal residues add 3 times of weight portions carries out the 2nd decoction 0.5-1 hour, the vacuum filtration slagging-off; Merge filtrate twice, Poria 15-45 part, Cordyceps (Cordyceps) 15-60 part, Rhizoma Atractylodis Macrocephalae (parched) 20-80 part of adding 120 mesh sieves stir, and it is 1: 20 that the low-temperature reduced-pressure distillation is concentrated into relative density; Again with the spray-dried one-tenth powder of concentrated solution.
This Chinese medicine not only has killing, suppresses the effect of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), and the most outstanding be to repair, to rebuild impaired body immune system, thereby can treat acquired immune deficiency syndrome (AIDS) effectively, centering, patients with terminal still have significant curative effect.Because this compositions has and keeps and promote CD
+ 8Mediation ctl response level, thereby have the viral infection of preventing AIDS, make HIV the infected's long term maintenance at disease-free state.
This Chinese medicine is identified by the animal simulation experiment and is clinical in HIV sufferers treatment checking, is that a kind of evident in efficacy can making by the destructive immunity of organism of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) recovers really, and can effectively suppresses the natural drug that has no side effect of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus).
Zhi Bei medicine is through clinical 241 routine acquired immune deficiency syndrome (AIDS) and acquired immune deficiency syndrome (AIDS) associated conditions patient's treatment checking like this, and this medicine has significant curative effect, total effective rate 95.8%.Take without any side effects, safe and reliable for a long time.
This medicated powder incapsulates and is capsule, every capsules 0.3 gram; The sealing bag of packing into is an electuary, every bag 12 gram.
Usage and consumption:
Capsule: obey the 3-6 grain after meal half an hour, take every day continuously, and every three months is a course of treatment, warm boiled water.
Electuary: respectively obey 1/3 bag early, middle and late half an hour after meal, warm boiled water.
Concrete enforcement side takes by weighing 3 kilograms of the Radixs Astragali, 3 kilograms of chickens of tree, 3 kilograms of Radix Ginsengs, 5 kilograms in Fructus Jujubae, 1 kilogram of Pericarpium Citri Reticulatae, 2 kilograms of Atractylodes lancea (Thunb.) DC., 0.6 kilogram of Partition in Fructus Juglandis, 2 kilograms of red ganodermas, clean up cold water soak 2 hours under the room temperature condition of back, boil with the immersion decocting, for the first time amount of water is 6 times of above component, promptly 117.6 kg of water decoct Radix Ginseng, Fructus Jujubae earlier, 1.5 hour, add 3 kilograms in other component and crystal sugar again, decocted 45 minutes; Boil with big fire earlier, transfer little fire to and keep slight boiling condition, decocting liquid is standby through vacuum filtration; In addition medicinal residues are added 3 times of amounts promptly 58.8 kilograms water carry out the 2nd time and decocted the vacuum filtration slagging-off 1 hour; Merge filtrate twice, added 1.5 kilograms in Poria, 1.5 kilograms of Cordyceps (Cordyceps), 2 kilograms of the Rhizoma Atractylodis Macrocephalae (parched)s of 120 mesh sieves, stir, it is 1: 20 that the low-temperature reduced-pressure distillation is concentrated into relative density; Again concentrated solution is injected in the spray drying tower, adopt spray drying method, at shower nozzle compressed air [3982-490Kpa (4-5Kg/CM
2)] medicine liquid spray is dried to powder, incapsulate every 0.3 gram; The packaging bag of packing into restrains for every bag 12.
The pharmacological action of this Chinese medicine:
The pharmacological action of this Chinese medicine is to repair, rebuild impaired body immune system, stimulates the interior stem cell of bone marrow to generate new granular lymphocyte and NK cell: to recover thymus function, strengthen the inductive lymphproliferation response of mitogen, promote propagation, the differentiation of T cell; The propagation and the differentiation of energy irritation cell toxicity T cell impel the repressed T4 of body, Tc activation recovering; Promote the mononuclear phagocyte function, promote the generation of IL-1, IL-2 and IFN-γ (interferon), increase OKT4/IL-2 and express the cell number of IL-2 receptor; Body cell multiplication had facilitation; Damage has protective effect to lymphocyte DNA; Has anti-modificator gene mutation effect; Adjust immune status, the immune response system that is changing in the body is produced balanced action; To the very strong inhibitory action of duplicating of HIV (human immunodeficiency virus), suppress the RT activity of virus; Stop HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) in conjunction with target cell, stop by the cell fusion of the cell of viral infection with contiguous uninfection; Suppress the cellular replication of AIDS viral infection, and can kill the cell of AIDS viral infection, and not infected normal cell is protected.
The animal simulation experiment
The result shows that this compositions is suppressed PFC (plaque forming cells), SRFC (the specificity rosettes of mice to normal mouse and immunity
Form) and DTH (delayed is super quick) test, tangible immunologic enhancement all shown.
Normal mouse bone marrow stem cell after low dose of gamma-rays is handled there is tangible promotion proliferation function, promote the formation of new granular lymphocyte, granulocyte monocytic series colony forming unit (CFU-GM), the medulla hematopoietic system function is also had comprehensive facilitation.Under the condition that the hemopoietic function that injection causes to cyclophosphamide (CY) obviously suppresses, can promote mice peripheral blood leucocyte, granulocyte, bone marrow nucleated cell, CFU-GM, lymphocyte to return to normal level.Point out this medicine to have the pharmacological action of reparation, reconstruction immunodeficiency.
This compositions can increase the auxiliary lymphocyte of T, CTL cell, NK cell number and the vigor that immunity is suppressed mice.What deserves to be explained is that especially many experiments report confirms, in asymptomatic HIV the infected's body, can measure the specific CTL of multiple anti-H IV, comprise anti-env, gag/pol, RT, P17, P24, p41, and proteic Specific CTL Cells such as nef.Experiment is also found to carry and do not send out the patient and isolate CD at long-term HIV
8Cell, or after effectively controlling the CTL cell function, the HIV replication capacity is just in rising trend.Experiment has also proved at external specific CTL can kill the CD that is infected by HIV effectively
4Cell, and can kill and wound the macrophage that HIV infects.This shows that ctl response is not only providing important anti-infective protection to the infected not, but also can control duplicating and lethal effect of HIV after infection.Thereby the prompting said composition is by repairing, rebuilding patient's immunodeficiency, keeps and promotes body CD
8 +Mediation ctl response level reaches the infection that prevents AIDS, and HIV is being infected be maintained in disease-free state, and to the immune pharmacological action of repairing and killing HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of HIV sufferers.Can improve generation level and the biological activity of lymphokine IL-1 and IL-2, IFN-γ (interferon).
It is heavy to increase mice spleen, and directly promotes the propagation of T, bone-marrow-derived lymphocyte, promotes the phagocytic activity of macrophage, strengthens the protective effect to the lymphocyte DNA damage, has anti-modificator gene mutation effect.
Can improve immunity and be suppressed anakinetomer content in the mouse red blood cell, reduce the blood number of free radical, improve SOD (superoxide dismutase) vigor in the tissue, increase blood plasma GSH content, reduce MAO-B (monoamine oxidase, MAO), and can improve the anti-anoxia ability of experiment mice from integral level, keep anakinetomer normal contents in the anoxia heart, the cerebral tissue, keep homergy to regulate, improve oxygen content in the blood, reduce oxygen consumption, strengthen myocardial contraction and point out this medicine to have comprehensive enhancing physiological function, improve the effect of body constitution and vitality.
Mice can't measure half lethal dose (LD in studies on acute toxicity
50), under 200 times of the suitable human body taking doses of mice taking dose, still can not cause dead mouse.In subacute toxicity research, to give continuously and raise 6 months mice weight increase, other every tests are all similar to matched group.
Clinical case is summed up
Clinical case data (one):
This organizes in 9 examples, full-blown AIDS patient be from June in August, 1994 to nineteen ninety-five in Sydney, AUS, abandon, stop using Western medicine voluntarily and accept this combination treatment.All detect before the treatment and show the HIV positive, meet WTO becoming the case definition of human AIDS through ELISA.Wherein age of onset 23-55 year, be male Australian, the course of disease 3 examples more than 10 years, 2 examples more than 5 years, 4 examples below 3 years, KS (skin carcinoma) 7 examples (88.9%) that wherein occur together, PCP (companion's intractable cough) 2 examples (22.3%) CD
+ 4Cell number 0.089-0.39 * 10
9/ L, average 0.175 * 10
9/ L is in clinical being diagnosed as, full-blown AIDS sends out the patient.Clinical symptoms feature: weak 9 examples (100%), lymph enlargement 6 examples (66.7%), low grade fever 2 examples (22.3%) that continue, indigestion and loss of appetite 4 examples (44.5%), diarrhoea 1 example (11%), candidiasis 1 example (11%).Pain (inclined to one side head, abdomen, skeleton all over the body) 6 examples (66.7%).
The result: all 9 routine patients are after 1-9 the course of treatment, and all mitigation symptoms eliminations gradually of described symptom are got well before the treatment, and body weight has all increased 0.5-4.5Kg, average 1.5Kg, CD
+ 4Cell number improves 0.05-0.15 * 10
9/ L, wherein the part patient detects HIVP
24Antigen is eliminated fully, and total effective rate reaches 95.8%.
The treatment of skin carcinoma: the acquired immune deficiency syndrome (AIDS) skin carcinoma that occurs together is a kind of true property malignant tumor of endotheliocyte, and add up internal organs (liver, intestines and stomach, lung and lymph node) generally to be considered to the course of disease anxious more, the case fatality rate height, the current that lives forever most 36 months, average survival period 18 months, the treatment difficulty, unrooted removes therapy.And this group is accepted 7 examples for medical treatment and is all met U.S. CDC and determine diagnostic criteria, and the concurrent skin carcinoma of determining according to pathology detection of acquired immune deficiency syndrome (AIDS).The clinical manifestation skin lesion is extensive, and the brown macule that the visible range degree is different, hard speckle and the hard lump that swells did not wait in course of disease 2.5-35 month, and wherein 1 example is recidivist behind the radiotherapy.The state of an illness commentariess on classics of getting better in general 1 week, 1-3 month focus is by hard, thick deliquescing gradually, thin, and complete obiteration at last reaches healing.
Clinical case data (two):
This organize 16 routine patients be from year May in April, 1992 to 1999 successively in China, Australia, Canada, never or be reluctant to take Western medicine, only accept the AIDS virus carrier of this combination treatment merely.All detect the HIV positive, meet the Center for Disease Control (CDC) and be diagnosed as AIDS viral infection about acquired immune deficiency syndrome (AIDS) clinical case definition and do not send out the patient through the ELISA method.Wherein male 14 examples, women 2 examples, age 21-48 year, average 31.6 years old, infection time 2 examples more than 10 years, 8 examples, 6 examples below 3 years more than 5 years.CD
+ 4Cell number 0.82-1.26 * 10
9/ L, average 0.96 * 10
9/ L.
The result: sick after visiting 3-5 generally through the treatment of 2-6 the course of treatment, the patient of sending out is not all arranged, CD
+ 4Cell number maintains normal level, and HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) is subjected to controlling effectively.
Claims (3)
1. Chinese medicine composition for the treatment of acquired immune deficiency syndrome (AIDS) is characterized in that making by following raw materials in weight portion:
Radix Ginseng 10-30 part Radix Astragali 20-60 part tree chicken 10-30 part
Pericarpium Citri Reticulatae 15-45 part Atractylodes lancea (Thunb.) DC. 20-60 part Poria 15-45 part
Partition in Fructus Juglandis 6-20 part Fructus Jujubae 50-100 part Cordyceps 15-60 part
Red ganoderma 15-60 part Rhizoma Atractylodis Macrocephalae (parched) 20-80 part crystal sugar 20-60 part.
2. Chinese medicine composition for the treatment of acquired immune deficiency syndrome (AIDS) is characterized in that making by following raw materials in weight portion:
30 parts of 30 parts of trees of 30 parts of Radixs Astragali of Radix Ginseng chickens
15 parts in 20 parts of Poria of 10 parts of Atractylodes lancea (Thunb.) DC. of Pericarpium Citri Reticulatae
15 parts of 50 parts of Cordyceps of 6 portions of Fructus Jujubaes of Partition in Fructus Juglandis
30 parts in 20 portions of crystal sugar of 20 parts of Rhizoma Atractylodis Macrocephalae (parched)s of red ganoderma.
3. preparation method for the treatment of the Chinese medicine composition of acquired immune deficiency syndrome (AIDS), it is characterized in that taking by weighing by weight Radix Astragali 20-60 part, tree chicken 10-30 part, Radix Ginseng 10-30 part, Fructus Jujubae 50-100 part, Pericarpium Citri Reticulatae 15-45 part, Atractylodes lancea (Thunb.) DC. 20-60 part, Partition in Fructus Juglandis 6-20 part, red ganoderma 15-60 part, clean up back cold water soak 1-2 hour, boil with the immersion decocting, for the first time amount of water is 6 times of above component, decoct Radix Ginseng, Fructus Jujubae earlier, 1.5-2 hour, add other components and crystal sugar 20-60 part again, decocted 30-45 minute; Decocting liquid is standby through vacuum filtration; The water that medicinal residues add 3 times of weight portions carries out the 2nd decoction 0.5-1 hour, the vacuum filtration slagging-off; Merge filtrate twice, Poria 15-45 part, Cordyceps 20-60 part, Rhizoma Atractylodis Macrocephalae (parched) 20-80 part of adding 120 mesh sieves stir, and it is 1: 20 that the low-temperature reduced-pressure distillation is concentrated into relative density; Again with the spray-dried one-tenth powder of concentrated solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011449519A CN1186042C (en) | 2001-12-25 | 2001-12-25 | Chinese medicine composition for curing AIDS and its preparation mehtod |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011449519A CN1186042C (en) | 2001-12-25 | 2001-12-25 | Chinese medicine composition for curing AIDS and its preparation mehtod |
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| Publication Number | Publication Date |
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| CN1428166A CN1428166A (en) | 2003-07-09 |
| CN1186042C true CN1186042C (en) | 2005-01-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011449519A Expired - Fee Related CN1186042C (en) | 2001-12-25 | 2001-12-25 | Chinese medicine composition for curing AIDS and its preparation mehtod |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103446202B (en) * | 2012-05-29 | 2018-11-06 | 江中药业股份有限公司 | A kind of composition and preparation method thereof of prevention and treatment AIDS |
| CN106074891A (en) * | 2016-07-29 | 2016-11-09 | 桂林淮安天然保健品开发有限公司 | Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof |
| CN106138162A (en) * | 2016-07-29 | 2016-11-23 | 桂林淮安天然保健品开发有限公司 | The pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) |
| CN105998143A (en) * | 2016-07-29 | 2016-10-12 | 桂林淮安天然保健品开发有限公司 | Anti-HIV pharmaceutical composition and preparation method thereof |
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