CN106074891A - Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof - Google Patents
Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof Download PDFInfo
- Publication number
- CN106074891A CN106074891A CN201610624266.2A CN201610624266A CN106074891A CN 106074891 A CN106074891 A CN 106074891A CN 201610624266 A CN201610624266 A CN 201610624266A CN 106074891 A CN106074891 A CN 106074891A
- Authority
- CN
- China
- Prior art keywords
- aids
- pharmaceutical composition
- filtering residue
- filtrate
- immune deficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition treating acquired immune deficiency syndrome (AIDS) and preparation method thereof, this medicine includes the component of following weight portion: Semen Vitis viniferae 0.1～0.5 part, Ganoderma 2～4 parts, Auricularia 0.5～1 part and Fructus Momordicae 5～8 parts.Its preparation method is 1) Semen Vitis viniferae, Ganoderma, Auricularia are first used ethanol extraction, its filtering residue with water extraction, takes filtrate standby again；2) by Fructus Momordicae first with ethanol extraction, its filtering residue extracting in water, filtrate is taken standby；3) by step 2) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；4) by step 1) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；5) effluent and concentrated solution are mixed, concentrate, be dried, to obtain final product.The medicine of the present invention can block HIV entrance target cell by Mutiple Targets, it is thus achieved that collaborative AntiHIV1 RT activity effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of pharmaceutical composition treating acquired immune deficiency syndrome (AIDS) and preparation side thereof
Method.
Background technology
Acquired immune deficiency syndrome (AIDS), i.e. acquired immune deficiency syndrome (AIDS) (Acquired Immunodeficiency Syndrome,
AIDS), it is to be infected, by HIV (human immunodeficiency virus) (Human Immundeficiency Virus, HIV), the chronic infection caused
Sick.Under HIV (human immunodeficiency virus) directly or indirectly acts on, T cell immunodeficiency, the simultaneously all different journey of other immunocytes
Spend impaired, promote various serious opportunistic infection and tumor to occur, cause death.Concrete, HIV is by attacking human immunity
System, destroys immunologic balance, so that human infection Other diseases, causes various MOI and dead.Inhibition of HIV infects place
After chief cell, amount reproduction, destruction CD4+ T lymphocyte, makes Abwehrkraft des Koepers decline, cause various MOI occur and dead
Die.Common infection is such as: hepatitis C, pulmonary tuberculosis, fungal infection, banding spore rash, pneumocystis carinii pneumonia, encephalitis and pernicious swollen
The generation etc. of tumor.
HIV belongs to RNA retrovirus, is divided into two kinds of hypotypes of HIV-1 and HIV-2, and the pathogenicity of HIV-1 is strong, is the whole world
The main pathogens of HIV/AIDS Epidemic.The course of infection of cell is included by HIV-1: adsorb, merge, reverse transcription, integrate, transcribe and
The expression of virus protein, assemble and shell.Based on the understanding to HIV-1 life cycle, replicate week with different strategy restriction HIV
Interim some or several crucial target, thus reach to suppress virus replication and the effect of infection.There are 26 kinds of anti-AIDS at present
Chemical entities medicine is approved by the FDA in the United States listing, including 15 kinds of reverse transcriptase inhibitors, and 8 kinds of protease inhibitor, a kind
Integrase inhibitor, a kind of CCR5 cooperative expert systems inhibitor, a kind of membrane fusion inhibitor.These single target drugs of prolonged application are easily
Produce multiple or cross resistance and serious toxic and side effects so that it is clinical practice is very restricted.Therefore research and development are efficiently
The anti-AIDS drug of overriding resistance and new therapy are the challenging problems of current medical chemical field.
Clinically, the multidrug therapies being characterized with multi-medicament use in conjunction, i.e. efficient reverse transcribe therapy
(HAART) can strengthen to a certain extent and persistently suppress the effect of virus replication, the generation of cushion drug resistance, medicine is drawn
The variation of the virus of the same race risen has mutual restrictive function concurrently.But this therapy cannot thoroughly remove HIV (human immunodeficiency virus), once drug withdrawal
The most repeatedly, immunologic function can reduce again the rear state of an illness.Additionally, the toxic and side effects of HAART therapy is obvious, such as hyperlactacidemia, liver
Toxicity, hyperglycemia, fatty improper distribution, erythra, hemophiliac increase hemorrhage, hyperlipemia, osteoporosis etc., easily
Produce drug resistance, and expensive.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition treating acquired immune deficiency syndrome (AIDS) and preparation method thereof, should
Compositions is not only with CD4 binding site on gp120 as target spot, and interference gp120 with CD4 is combined, and stops HIV to enter target cell, presses down
The duplication of system virus, also with gp41 trimer as target spot, by stoping the formation of Six helix bundle structure, thus suppresses HIV and target
Cell furthers fusion, it is thus achieved that collaborative AntiHIV1 RT activity effect.
The technical scheme that the present invention provides is a kind of pharmaceutical composition treating acquired immune deficiency syndrome (AIDS), including the group of following weight portion
Point: Semen Vitis viniferae 0.1～0.5 part, Ganoderma 2～4 parts, Auricularia 0.5～1 part and Fructus Momordicae 5～8 parts.
In above-mentioned prescription, effect of each raw material is as follows:
Semen Vitis viniferae contains abundant several amino acids, vitamin and mineral etc. and has effect of health care, beauty treatment.
Ganoderma, formal name used at school: Ganoderma Lucidum Karst, is the sporophore of On Polyporaceae Ganoderma.There is QI invigorating
Calm the nerves, effect of relieving cough and asthma, for dizziness sleeplessness, shortness of breath and palpitation, neurasthenia, asthenia cough with asthma, effect of life lengthening.
Auricularia, has another name called black dish, and Mulberry, this bacterium, tree chicken, wood moth, wood are fine and soft, because of likeness in form ear, in addition its color pitchy and
Gaining the name, Auricularia is Auriculariaceae plant, its flat sweet in the mouth of property, people's stomach, large intestine channel.There is nourishing, moisturize, the stomach reinforcing that nourishes blood, only invigorate blood circulation
Blood, lung moistening, the effect of intestine moistening.
Fructus Momordicae, the fruit of the perennial liana of Cucurbitaceae, mainly originates in Yongfu county, Guangxi Zhuang Autonomous Region Guilin City
Longjiang township, dragon victory and hundred Shou Deng towns.Fructus Momordicae is the local and special products that Guilin is famous and precious, is also the medicine-food two-purpose material of the first batch of approval of country
One of, its primary efficacy is can relieving cough and resolving phlegm.Fruits nutrition is worth the highest, (contains in every 100 grams of fresh fruits containing abundant vitamin C
400 milligrams～500 milligrams) and glucoside, fructose, glucose, protein, lipid etc..
As preferably, the weight portion of each component is: Semen Vitis viniferae 0.1～0.2 part, Ganoderma 2～2.5 parts, Auricularia 0.5～
0.6 part and Fructus Momordicae 7～8 parts.
The invention also discloses the above-mentioned preparation side blocking the pharmaceutical composition that cytomegalovirus is transmitted between mother and baby
Method, comprises the following steps:
1) Semen Vitis viniferae of formula ratio, Ganoderma, Auricularia are pulverized, extract for solvent with ethanol, extracting solution is filtered,
Take filtering residue standby；
2) by step 1) filtering residue extracting in water, by extracting solution filter, take filtrate standby；
3) Fructus Momordicae is pulverized, extract for solvent with ethanol, extracting solution is filtered, takes filtering residue standby；
4) by step 3) filtering residue extracting in water, by extracting solution filter, take filtrate standby；
5) by step 4) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；
6) by step 2) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；
7) by step 5) effluent and step 6) concentrated solution mixing, concentrate, be dried, to obtain final product.
Step 1) and step 3) in, owing to Semen Vitis viniferae, Ganoderma, Auricularia and Fructus Momordicae containing protein and carbon hydrate
Thing, employing ethanol is solvent, is unfavorable for the dissolving of protein and carbohydrate, can reduce the dissolution of impurity component.
Step 1) and step 3) in, the consumption of ethanol is 8～10 times of medicinal powder weight, reflux, extract, 1～3 times, often
Secondary 1～3h.I.e. step 1) in, the consumption of ethanol is Semen Vitis viniferae, Ganoderma and 8～10 times of Auricularia mixed-powder weight, backflow
Extract 1～3 time, each 1～3h.Step 3) in, the consumption of ethanol is 8～10 times of Grosvenor Momordica Fruit weight, reflux, extract, 1～
3 times, each 1～3h.
As preferably, the volumetric concentration of ethanol is 90～95%.
Step 2) and step 4) in, with water as solvent, the macromolecular polysaccharide in filtering residue and small molecular sugar glycosides, water can be extracted
Addition is filtering residue weight 8～10 times, reflux, extract, 1～3 times, each 1～3h.
Step 5) in, the polysaccharide of Fructus Momordicae and small molecular sugar glycosides extracting solution are crossed molecular cut off is 1000 daltonian films
Defecator, collecting effluent is the small molecular sugar glycosides that molecular weight is less than 1000.Fructus Momordicae small molecular sugar glycosides can disturb AIDS
The receptor CD4 being coated glycoprotein gp120 and T lymphocytic cell surface of virus coated film is combined and forms the compound of gp120 Yu CD4
Thing, stops HIV (human immunodeficiency virus) to enter target cell, defines the first line of defence of anti HIV-1 virus.
Step 6) in, the polysaccharide of Semen Vitis viniferae, Ganoderma and Auricularia and the extracting solution of small molecular sugar glycosides are crossed molecular cut off
It is 15000 daltonian film filters, many more than 15000 daltonian macromole containing molecular weight in the concentrated solution of collection
Sugar.This macromolecular polysaccharide can suppress the change of gp41 trimer occurred conformation with transmembrane glycoprotein gp41 as target spot, block stable
The formation of Six helix bundle structure, thus prevent peplos from furthering with target cell membrane and merging, suppression HIV target is thin
Born of the same parents.
Compared with prior art, the pharmaceutical composition of the present invention is Mutiple Targets medicine, not only with CD4 bound site on gp120
Point is target spot, and interference gp120 with CD4 is combined, and stops HIV to enter target cell, the duplication of suppression virus, with gp41 trimer is also
Target spot, by stoping the formation of Six helix bundle structure, thus suppresses HIV and target cell to further fusions, it is thus achieved that collaborative AntiHIV1 RT activity work
With.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Embodiment 1
Formula: Semen Vitis viniferae 0.1 part, Ganoderma 2 parts, Auricularia 0.5 part and Fructus Momordicae 5 parts.
Preparation method:
1) Semen Vitis viniferae of formula ratio, Ganoderma, Auricularia are pulverized, extract for solvent with 90v% ethanol, the use of ethanol
Amount is 8 times of mixed-powder weight, and extracting solution is filtered, takes filtering residue standby by reflux, extract, 1h；
2) by step 1) filtering residue extracting in water, the addition of water is 8 times of filtering residue weight, reflux, extract, 1h, will extract
Liquid filters, and takes filtrate standby；
3) being pulverized by Fructus Momordicae, extract for solvent with 90v% ethanol, the consumption of ethanol is Grosvenor Momordica Fruit weight
8 times, reflux, extract, 1h, filters extracting solution, takes filtering residue standby；
4) by step 3) filtering residue extracting in water, the addition of water is 8 times of filtering residue weight, reflux, extract, 1h, will extract
Liquid filters, and takes filtrate standby；
5) by step 4) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；
6) by step 2) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；
7) by step 5) effluent and step 6) concentrated solution mixing, concentrate, be dried, to obtain final product.
Embodiment 2
Formula: Semen Vitis viniferae 0.5 part, Ganoderma 4 parts, Auricularia 1 part and Fructus Momordicae 8 parts.
Preparation method:
1) Semen Vitis viniferae of formula ratio, Ganoderma, Auricularia are pulverized, extract for solvent with 95v% ethanol, the use of ethanol
Amount is 10 times of mixed-powder weight, reflux, extract, 3 times, and extracting solution is merged by each 3h, filters, takes filtering residue standby；
2) by step 1) filtering residue extracting in water, the addition of water is 10 times of filtering residue weight, reflux, extract, 3 times, every time
3h, merges extracting solution, filters, takes filtrate standby；
3) being pulverized by Fructus Momordicae, extract for solvent with 95v% ethanol, the consumption of ethanol is Grosvenor Momordica Fruit weight
10 times, reflux, extract, 3 times, each 3h, extracting solution is merged, filters, take filtering residue standby；
4) by step 3) filtering residue extracting in water, the addition of water is 10 times of filtering residue weight, reflux, extract, 3 times, every time
3h, filters extracting solution, takes filtrate standby；
5) by step 4) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；
6) by step 2) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；
7) by step 5) effluent and step 6) concentrated solution mixing, concentrate, be dried, to obtain final product.
Embodiment 3
Formula: Semen Vitis viniferae 0.1 part, Ganoderma 2 parts, Auricularia 0.5 part and Fructus Momordicae 7 parts.
Preparation method:
1) Semen Vitis viniferae of formula ratio, Ganoderma, Auricularia are pulverized, extract for solvent with 90v% ethanol, the use of ethanol
Amount is 9 times of mixed-powder weight, reflux, extract, 2 times, and extracting solution is merged by each 2h, filters, takes filtering residue standby；
2) by step 1) filtering residue extracting in water, the addition of water is 9 times of filtering residue weight, reflux, extract, 2 times, every time
2h, merges extracting solution, filters, takes filtrate standby；
3) being pulverized by Fructus Momordicae, extract for solvent with 95v% ethanol, the consumption of ethanol is Grosvenor Momordica Fruit weight
9 times, reflux, extract, 2 times, each 2h, extracting solution is merged, filters, take filtering residue standby；
4) by step 3) filtering residue extracting in water, the addition of water is 9 times of filtering residue weight, reflux, extract, 2 times, every time
2h, merges extracting solution, filters, takes filtrate standby；
5) by step 4) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；
6) by step 2) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；
7) by step 5) effluent and step 6) concentrated solution mixing, concentrate, be dried, to obtain final product.
Embodiment 4
Formula: Semen Vitis viniferae 0.2 part, Ganoderma 2.5 parts, Auricularia 0.6 part and Fructus Momordicae 8 parts.
Preparation method:
1) Semen Vitis viniferae of formula ratio, Ganoderma, Auricularia are pulverized, extract for solvent with 90v% ethanol, the use of ethanol
Amount is 10 times of mixed-powder weight, and extracting solution is filtered, takes filtering residue standby by reflux, extract, 3h；
2) by step 1) filtering residue extracting in water, the addition of water is 8 times of filtering residue weight, reflux, extract, 3 times, every time
1h, merges extracting solution, filters, takes filtrate standby；
3) being pulverized by Fructus Momordicae, extract for solvent with 95v% ethanol, the consumption of ethanol is Grosvenor Momordica Fruit weight
8 times, reflux, extract, 3 times, each 1h, extracting solution is merged, filters, take filtering residue standby；
4) by step 3) filtering residue extracting in water, the addition of water is 10 times of filtering residue weight, reflux, extract, 3h, will extract
Liquid filters, and takes filtrate standby；
5) by step 4) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；
6) by step 2) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；
7) by step 5) effluent and step 6) concentrated solution mixing, concentrate, be dried, to obtain final product.
Experimental example
1, clinical case
Choosing and be diagnosed as HIV positive patient 120 example, age 30～61 years old through ELISA and WB, the mean age is 43.8 years old,
Wherein, male 62 example, women 58 example.Through Sex transmitted pathogen person 76 example, blood infection person 44 example.It is randomly divided into 5 groups, is respectively real
Test group 1～4 and matched group, often organize 20 examples.
2, Therapeutic Method: experimental group 1～4 takes the medicine of the embodiment of the present invention 1～4, every day 2 times, each 0.1mg (phase
When in crude drug 1～5g), oral, take 1 year continuously.Matched group 1 takes Granule AiLing, each 2 bags, often wraps 10g and (is equivalent to raw
Medicine 41.5g), every day 2 times.Matched group 2 uses HARRT therapy (AZT+3TC+NVP).
2, efficacy determination
Clinical efficacy evaluation criteria: " the Treating AIDS with Traditional Chinese Medicine pilot project formulated according to State Administration of Traditional Chinese Medicine
Clinical technology scheme ", the standard of curative effect evaluation is as follows:
Effective: Clinical symptom and sign improves substantially, and total mark declines >=1/3；CD4Raise >=30% or 50ul；Virus carries
Amount reduces ＞ 0.5 1og/ml.
Stable: Clinical symptom and sign makes moderate progress, total mark declines ＜ 1/3；CD4Raise ＜ 30% or 50ul；Virus carries
Amount rises or falls ＜ 0.5 1og/ml.
Invalid: Clinical symptom and sign is without improving or increasing the weight of, and total mark does not declines or increases；CD4Decline >=30% or 50u1；
Viral load levels persistently rises, and copy number rises ＞ 0.5 1og/ml.
3, result
| Group | Effectively | Stable | Invalid | Effective percentage (%) |
| Enforcement group 1 | 12 | 6 | 2 | 90 |
| Enforcement group 2 | 10 | 8 | 2 | 90 |
| Enforcement group 3 | 14 | 5 | 1 | 95 |
| Enforcement group 4 | 13 | 5 | 2 | 90 |
| Matched group 1 | 6 | 6 | 8 | 60 |
| Matched group 2 | 7 | 6 | 7 | 65 |
Effective percentage=(efficiently individual quantity+stablize number)/total number of persons × 100%
The medicine of the present invention can enter target cell with inhibiting HIV, and then suppresses it to transcribe, and reaches to extend acquired immune deficiency syndrome (AIDS)
The period of disease of people and life cycle, its effect is far superior to matched group.
As a comparison, present invention applicant carries out anti-AIDS to Semen Vitis viniferae, Auricularia, Ganoderma, Fructus Momordicae folk prescription the most respectively
Viral experiment, result shows that the effect of prescription of the present invention is considerably beyond above folk prescription effect.
Claims (6)
1. treat the pharmaceutical composition of acquired immune deficiency syndrome (AIDS), it is characterised in that: include the component of following weight portion: Semen Vitis viniferae 0.1～0.5
Part, Ganoderma 2～4 parts, Auricularia 0.5～1 part and Fructus Momordicae 5～8 parts.
The pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) the most according to claim 1, it is characterised in that: the weight portion of each component is:
Semen Vitis viniferae 0.1～0.2 part, Ganoderma 2～2.5 parts, Auricularia 0.5～0.6 part and Fructus Momordicae 7～8 parts.
3. the preparation method of the pharmaceutical composition of the treatment acquired immune deficiency syndrome (AIDS) described in claim 1 or 2, it is characterised in that: include following
Step:
1) Semen Vitis viniferae of formula ratio, Ganoderma, Auricularia are pulverized, extract for solvent with ethanol, extracting solution is filtered, takes filter
Slag is standby；
2) by step 1) filtering residue extracting in water, by extracting solution filter, take filtrate standby；
3) Fructus Momordicae is pulverized, extract for solvent with ethanol, extracting solution is filtered, takes filtering residue standby；
4) by step 3) filtering residue extracting in water, by extracting solution filter, take filtrate standby；
5) by step 4) filtrate to cross molecular cut off be 1000 daltonian film filters, collect effluent；
6) by step 2) filtrate to cross molecular cut off be 15000 daltonian film filters, collect concentrated solution；
7) by step 5) effluent and step 6) concentrated solution mixing, concentrate, be dried, to obtain final product.
The preparation method of the pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) the most according to claim 3, it is characterised in that: step 1) and
Step 3) in, the consumption of ethanol is 8～10 times of medicinal powder weight, reflux, extract, 1～3 times, each 1～3h.
The preparation method of the pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) the most according to claim 4, it is characterised in that: the body of ethanol
Volume concentrations is 90～95%.
The preparation method of the pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) the most according to claim 3, it is characterised in that: step 2) and
Step 4) in, the addition of water is 8～10 times of filtering residue weight, reflux, extract, 1～3 times, each 1～3h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610624266.2A CN106074891A (en) | 2016-07-29 | 2016-07-29 | Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610624266.2A CN106074891A (en) | 2016-07-29 | 2016-07-29 | Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106074891A true CN106074891A (en) | 2016-11-09 |
Family
ID=57478923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610624266.2A Pending CN106074891A (en) | 2016-07-29 | 2016-07-29 | Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106074891A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428166A (en) * | 2001-12-25 | 2003-07-09 | 刘文珊 | Chinese medicine composition for curing AIDS and its preparation mehtod |
| CN101314024A (en) * | 2008-07-17 | 2008-12-03 | 王跃进 | Traditional Chinese medicine capsule for treating AIDS |
| CN102579781A (en) * | 2012-02-28 | 2012-07-18 | 周伟真 | Traditional Chinese medicine with cancer and AIDS (acquired immune deficiency syndrome) resistance and preparation method thereof |
| CN106177786A (en) * | 2016-08-25 | 2016-12-07 | 广东赤帝生命科技有限公司 | A kind of Chinese medicine composition treating acquired immune deficiency syndrome (AIDS) and preparation method thereof |
-
2016
- 2016-07-29 CN CN201610624266.2A patent/CN106074891A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428166A (en) * | 2001-12-25 | 2003-07-09 | 刘文珊 | Chinese medicine composition for curing AIDS and its preparation mehtod |
| CN101314024A (en) * | 2008-07-17 | 2008-12-03 | 王跃进 | Traditional Chinese medicine capsule for treating AIDS |
| CN102579781A (en) * | 2012-02-28 | 2012-07-18 | 周伟真 | Traditional Chinese medicine with cancer and AIDS (acquired immune deficiency syndrome) resistance and preparation method thereof |
| CN106177786A (en) * | 2016-08-25 | 2016-12-07 | 广东赤帝生命科技有限公司 | A kind of Chinese medicine composition treating acquired immune deficiency syndrome (AIDS) and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 南朝君: "《食疗莹莹与烹调》", 31 January 2014 * |
| 潘道东: "《功能性食品添加剂》", 31 January 2006 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1762236B (en) | Health-caring product capable of increasing human immunity and its preparation method | |
| CN103932173A (en) | Composition for dispelling alcohol effect and protecting liver | |
| CN102106889A (en) | Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract | |
| CN112569305A (en) | Mushroom compound polysaccharide composition for improving immunity and preparation method thereof | |
| CN102630939A (en) | Health-care food for treating AIDS (acquired immunodeficiency syndromes) by increasing immunity through dietary therapy and preparation method thereof | |
| CN104721508B (en) | A kind of pharmaceutical composition and preparation method for treating the infection of the upper respiratory tract | |
| CN106074891A (en) | Pharmaceutical composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof | |
| CN101554396B (en) | Traditional Chinese medicine for treating diabetes and hyperlipidemia | |
| CN103211224A (en) | Preparation process of compound health care food capable of rapidly recovering physical strength of man | |
| CN102204956B (en) | Chinese medicinal composition used at stroke recovery period and preparation method thereof | |
| CN103768454B (en) | A kind of composition with prevention and treatment HIV/AIDS and preparation method thereof | |
| CN102631492B (en) | Chinese medicinal composition for improving immunity and resisting fatigue | |
| CN107137621A (en) | It is a kind of to treat Chinese medicine composition of high fat of blood and its preparation method and application | |
| CN107669710A (en) | A kind of active components of glossy ganoderma composition and preparation method thereof and purposes | |
| CN108686126A (en) | A kind of liver-protecting and alcoholism-relieving prescription and preparation and application | |
| CN104510857B (en) | A kind of Chinese medicinal effective-part composition for blood fat reducing and preparation thereof | |
| CN109091645A (en) | A kind of pharmaceutical composition with treatment inhibition of HIV | |
| CN103721074B (en) | Pharmaceutical composition and preparation method and application thereof | |
| CN108079113A (en) | A kind of pharmaceutical composition for treating the postpartum deficiency of blood and preparation method thereof | |
| CN102631486B (en) | Health care composition | |
| CN105998143A (en) | Anti-HIV pharmaceutical composition and preparation method thereof | |
| CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| Lee et al. | Flu for you? The common cold, influenza, and traditional medicine | |
| CN102631489B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102389509B (en) | Traditional Chinese medicinal composition for treating HIV and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161109 |
|
| RJ01 | Rejection of invention patent application after publication |