CN107669710A - A kind of active components of glossy ganoderma composition and preparation method thereof and purposes - Google Patents
A kind of active components of glossy ganoderma composition and preparation method thereof and purposes Download PDFInfo
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Abstract
The present invention relates to a kind of active components of glossy ganoderma composition and preparation method thereof and purposes, belong to Chinese medicine, technical field of health care food.Active components of glossy ganoderma composition includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2, its weight ratio is (5 55)：(1.5‑15)：(1‑8)：(0.6‑6)：(0.5‑5).Its preparation method includes：30 95% ethanol relative to 5 30 times of raw material gross weight are added in the raw material including glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 13 times, 1 8h, filtering, recovery ethanol obtain alcohol extract every time；The water relative to 5 30 times of raw material gross weight is added in the dregs of a decoction after extraction, is extracted 13 times, 1 5h, filtering, appropriate concentration, obtains water extract every time；Merge alcohol extract and water extract, obtain active components of glossy ganoderma composition；Wherein the weight ratio of ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm is (6 12)：(1‑6).The present invention has the function that Nausea and vomiting caused by suppressing chemotherapy reacts.
Description
Technical field
The present invention relates to Chinese medicine, technical field of health care food, specifically a kind of active components of glossy ganoderma composition and its
Preparation method and purposes.
Background technology
In the long Chinese traditional herbs treasure-house in China, medical value and its strengthening by means of tonics, righting that ganoderma lucidum has with it
The unique effects such as consolidate, promote longevity to have won fame both at home and abroad.Ganoderma lucidum alias seocho, 10000 years grass etc., are a kind of large-scale medicinal fungis, belong to
Basidiomycetes hilllock Polyporaceae Ganoderma fungi, including red sesame Ganoderma lucidum (Levss.ex Fr.) Karst. and purple
Sesame Ganoderma sinenseZhao.Xu et zhang. drying fructification.With tonifying middle-Jiao and Qi, enriching yin is strong, righting is solid
Originally, promote longevity and other effects, successive dynasties medical book is classified as top grade.
Ganoderma lucidum triterpene compounds are one of active components important in ganoderma lucidum.Up to the present, oneself is successfully separated out three
Terpenoid more than 150 is planted, and wherein most is ganoderic acid.Triterpene compound is that particularly important having substantially is given birth in ganoderma lucidum
A kind of compound of activity is managed, has and suppresses a variety of physiologically actives such as tumour cell and antiviral activity, in addition also have
Hepatoprotective effect, antitumor action, anti-HIV-1 and HIV-1 proteinase activities, suppress cholesterol biosynthesis, analgesic activity, to blood platelet
The influence of aggregation, the ten big pharmacological actions to the inhibitory action and antioxidation of albumen Acacia transesterify enzyme.Show bright
Outside aobvious immune antitumor action, s, liver cancer cells to the tumor cell line such as people of some in vitro cultures
Hepq, leukaemia HL60Etc. there is direct toxic action.
Ganoderma lucidum includes substantial amounts of polysaccharide component, and the three-dimensional spiral structure of polysaccharide participates in its antitumor activity, destroys this structure
Then influence activity.It is considered as that ganoderma lucidum has that antitumor, regulation is immune, one of anti-aging, principle active component for strengthening the body resistance to consolidate the constitution,
It can strengthen the immunoregulation effect of cell, body fluid, adjust the metabolic balance of nucleic acid and protein, scavenging activated oxygen, extend
The ability of subculture in vitro separately cell division algebraically.
Lucidum glycopeptide (Ganoderma lucidum polysaccharides peptide GLPP) is by 16 kinds of amino acid
Form, research shows that GLPP has obvious protective function, particularly laser confocal microscope to the inside and outside oxygen free radical injury of body
Time series program scanning experimental result is shown, GLPP treated in vitro, quiescent condition mouse abdomen can be reduced rapidly in dosing moment
Chamber macrophage content of oxygen free radical, show that GLPP there can be direct scavenging action to free radical existing for oneself warp, make intracellular total
Free Radical Level reduce rapidly.In the content increase of oxygen radical caused by macrophage caused by PMA " respiratory burst ",
GLPP also can be such that its content reduces rapidly.
Lucidum spore powder is ganoderma lucidum in growth and maturity phase, the extremely small avette reproduction ejected from glossy ganoderma lamella
Cell is the seed of ganoderma lucidum.It has condensed the elite of ganoderma lucidum, rich in GL-B, triterpene acids, protein, more skins, amino acid,
The various bioactivators such as organic germanium, trace element and vitamin, there is strengthen immunity, radioresistance, remove free radical etc.
Multiple functions, and the property of medicine is gentle, has no side effect, but Reishi sporule surface is surrounded by hard chitin fiber element, and human body is very
Difficulty fully absorbs.Ganoderma spove powder mesospore shell accounting more than 60% on the market at present, is inactive portion, wall shell indigestibility meeting
Stomach burden is aggravated, has harmful effect to digestive system.In addition, contain substantial amounts of chitin fiber element in ganoderma spove powder
Deng causing real active ingredient in ganoderma spove powder, such as triterpenic acid, polysaccharide and glycopeptide active ingredient are in intestines and stomach system
It is difficult to be absorbed in system, and utilization rate is low.
Research confirms：The effective active composition contained in ganoderma lucidum and lucidum spore powder is mainly triterpenic acid, polysaccharide and glycopeptide.
Existing market is more to be existed with single ganoderma lucidum or the product formed with ganoderma lucidum and lucidum spore powder, and product composition marker is only single
One composition polyoses content, single component triterpene acid content or triterpenic acid and polysaccharide binary are as Con trolling index, due to quality mark
It is accurate low, so causing that in the market ganoderma lucidum and lucidum spore powder class product are very different, and quality is difficult to ensure that, threatens numerous people
Vital interests.
Cancer has turned into a big killer of facing mankind at present, and the death rate is only second to angiocardiopathy, and on year by year
The trend risen.There are 2,000,000 malignant tumor patients in China every year, wherein 2/3 patient receives chemotherapy, although there is the effect of certain,
But different degrees of side effect occurs in most of patient after chemotherapy, most common of which side effect is the stomach and intestine such as Nausea and vomiting
React in road.Frequently vomiting can cause digestive juice largely to be lost, and water, electrolyte, disturbance of acid-base balance, make patient agonizing,
The life quality of patient is had a strong impact on, not only influences whether curative effect, or even patient is difficult to endure and is interrupted treatment.At present, face
The conventional antiemetic of bed mainly has histamine (H2), acetylcholine (M) and dopamine (DA) receptor antagonist and cannabinoids drug etc.,
But the effect of these medicines are to vomit duo to chemotherapy is poor, and toxic side effect is strong, using being above very limited.New antiemetic,
Such as NK1Receptor antagonist and 5-HT3Receptor antagonist class medicine, it is expensive although effective to vomit duo to chemotherapy antiemetic, make
With narrow range, and toxicity is big, clinical to need drug combination more.
Research and develop a kind of high-efficiency low-toxicity, cheap, the easy to spread production that can be used for mitigating cancer chemotherapy vomiting side effect
Product turn into clinical urgent problem to be solved.
The content of the invention
The purpose of the embodiment of the present invention is to provide a kind of active components of glossy ganoderma composition, this active components of glossy ganoderma composition
With polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2Etc. active ingredient as key component, it ensure that product safety, have
Imitate, be quality controllable.
The another object of the embodiment of the present invention is to provide a kind of preparation method of active components of glossy ganoderma composition, retained
While ganoderma lucidum is with lucidum spore powder elite, the wall shell for being difficult to digest in lucidum spore powder, its preparation technology letter are effectively eliminated
It is single.
Active components of glossy ganoderma composition simultaneously involved in the present invention has the work that Nausea and vomiting caused by suppression chemotherapy reacts
With.
The embodiment of the present invention solves its technical problem using following technical scheme to realize：
It is raw material to weigh glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm according to certain weight ratio, is broken including glossy ganoderma powder and ganoderma lucidum
The 30-95% ethanol relative to 5-30 times of raw material gross weight, refluxing extraction 1-3 times, each 1- are added in the raw material of wall conidia powder
8h, filtering, recovery ethanol obtain alcohol extract；The water relative to 5-30 times of raw material gross weight, extraction 1-3 are added in the dregs of a decoction after extraction
It is secondary, each 1-5h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain active components of glossy ganoderma composition.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or instrument are the conventional products that can be obtained by commercially available purchase.
Below to the preparation method of active components of glossy ganoderma composition involved in the present invention, active components of glossy ganoderma composition with
And the action effect that nausea and vomiting caused by active components of glossy ganoderma composition suppression chemotherapy are reacted is specifically described.
A kind of active components of glossy ganoderma composition, it includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C 2, more
Sugar, glycopeptide, ganoderic acid A, the weight ratio of ganoderic acid B and ganoderic acid C 2 are (5-55)：(1.5-15)：(1-8)：(0.6-6)：
(0.5-5)；
Preferably, the weight ratio of the polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C 2 is (10-30)：(5-
15)：(4-12)：(3-8)：(2-8)；
Described active components of glossy ganoderma composition, it is characterised in that the polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and spirit
Sesame acid C2 is the extract of ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm, and the weight ratio of the ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm is (6-
12)：(1-6)；
Preferably, the weight of the ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm ratio is (6-12)：(2-5)；
It is further preferred that the weight of the ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm ratio is 2：1.
A kind of preparation method of active components of glossy ganoderma composition provided in an embodiment of the present invention, it comprises the following steps：
The 30- relative to 5-30 times of raw material gross weight is added in the raw material including glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm
95% ethanol, refluxing extraction 1-3 times, each 1-8h, filtering, recovery ethanol obtain alcohol extract；Added in the dregs of a decoction after extraction relative
In 5-30 times of water of raw material gross weight, extract 1-3 times, each 1-5h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and
Water extract, obtain active components of glossy ganoderma composition；Wherein the weight ratio of ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm is (6-12)：(1-6).
Preferably, it is 2 according to weight ratio：1 to weigh glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm be raw material, then including ganoderma lucidum
Add 75% ethanol relative to 10 times of raw material gross weight in the raw material of powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 2 times, every time
5h, filtering, recovery ethanol obtain alcohol extract；The water relative to 12 times of raw material gross weight is added in the dregs of a decoction after extraction, is extracted 2 times,
Each 2h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain active components of glossy ganoderma composition.
The active components of glossy ganoderma composition can be prepared as granule or (soft) capsule；Preferably, caused by suppression chemotherapy
The product forms of Nausea and vomiting reaction are soft capsule.
The preparation method of the embodiment of the present invention, technique is simple, reasonable raw material proportioning so that ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm
By the drug effect that maximum can have been given play to after alcohol reflux extraction and decocting.
The beneficial effect of the active components of glossy ganoderma composition of the embodiment of the present invention and preparation method thereof is：
Foregoing active ingredient provided in an embodiment of the present invention derives from ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm, has and suppresses chemotherapy
The effect of induced Vomiting reaction, while have that antitumor, regulation is immune, anti-aging, the multiple pharmacological effect such as strengthen the body resistance to consolidate the constitution, it is nontoxic
Side effect, reasonable recipe, and a variety of symptoms such as above-mentioned can be effectively treated by reasonably matching, curative effect is good.
The feature and performance of the embodiment of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 26：13：6：5：3.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 2 according to weight ratio：1 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 1500g be raw material, then including
Add 75% ethanol relative to 10 times of raw material gross weight in the raw material of glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 2 times,
Each 5h, filtering, recovery ethanol obtain alcohol extract；The water relative to 12 times of raw material gross weight, extraction 2 are added in the dregs of a decoction after extraction
It is secondary, each 2h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit ganoderma actives
Component composition.
Embodiment 2
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 25：11：6：4：3.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 3 according to weight ratio：1 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 1000g be raw material, then including
Add 85% ethanol relative to 10 times of raw material gross weight in the raw material of glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 2 times,
Each 3h, filtering, recovery ethanol obtain alcohol extract；The water relative to 10 times of raw material gross weight, extraction 2 are added in the dregs of a decoction after extraction
It is secondary, each 2h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit ganoderma actives
Component composition.
Embodiment 3
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 29：15：5：5：4.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 3 according to weight ratio：2 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 2000g be raw material, then including
Add 65% ethanol relative to 8 times of raw material gross weight in the raw material of glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 2 times,
Each 5h, filtering, recovery ethanol obtain alcohol extract；The water relative to 10 times of raw material gross weight, extraction 2 are added in the dregs of a decoction after extraction
It is secondary, each 2h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit ganoderma actives
Component composition.
Embodiment 4
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 5：1.5：8：6：5.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 12 according to weight ratio：1 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 250g be raw material, then including
Add 95% ethanol relative to 30 times of raw material gross weight in the raw material of glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 3 times,
Each 8h, filtering, recovery ethanol obtain alcohol extract；The water relative to 5 times of raw material gross weight, extraction 1 are added in the dregs of a decoction after extraction
It is secondary, time 1h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit ganoderma actives
Component composition.
Embodiment 5
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 55：15：1：0.6：0.5.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 1 according to weight ratio：1 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 3000g be raw material, then including
Add 30% ethanol relative to 5 times of raw material gross weight in the raw material of glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 1 time,
Time 1h, filtering, recovery ethanol obtain alcohol extract；The water relative to 30 times of raw material gross weight, extraction 3 are added in the dregs of a decoction after extraction
It is secondary, each 5h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit ganoderma actives
Component composition.
Embodiment 6
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 10：5：12：8：8.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 6 according to weight ratio：1 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 500g be raw material, then including spirit
Add 95% ethanol relative to 30 times of raw material gross weight in the raw material of sesame powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 3 times, often
Secondary 8h, filtering, recovery ethanol obtain alcohol extract；The water relative to 5 times of raw material gross weight is added in the dregs of a decoction after extraction, is extracted 1 time,
Time 1h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit active components of glossy ganoderma
Composition.
Embodiment 7
The active components of glossy ganoderma composition of the present embodiment includes polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2,
Its weight ratio is 30：15：4：3：2.
The active components of glossy ganoderma composition of the present embodiment is prepared by following preparation method.
It is 6 according to weight ratio：5 to weigh glossy ganoderma powder 3000g and glossy ganoderma spore powder with crushed sporoderm 2500g be raw material, then including
Add 30% ethanol relative to 5 times of raw material gross weight in the raw material of glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm, refluxing extraction 1 time,
Time 1h, filtering, recovery ethanol obtain alcohol extract；The water relative to 30 times of raw material gross weight, extraction 3 are added in the dregs of a decoction after extraction
It is secondary, each 5h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extract, obtain 1000 preparation unit ganoderma actives
Component composition.
Test example 1
The pharmacodynamic study of active components of glossy ganoderma composition treatment Nausea and vomiting effect
1st, test method：
Rat, male, ad lib is drunk water before experiment.Rat is randomly divided into 10 groups, every group 6, A groups are blank group, B
Group is model control group, and C groups are Ondansetron group, and D-J groups are respectively embodiment 1-7 groups.A, B groups are first to give physiological saline
5ml/kg ig；C groups, which are given, gives Ondansetron 4mg/kg ip pretreatments；D-J groups to corresponding 0.4 preparation unit of medicine/
Kg ig are pre-processed, successive administration thing three days, fasting after administration in second day.After 3rd day administration 30min in addition to A groups, give suitable
Platinum 3mg/kg ip, observation each group upon administration in 6h rat different thermophilic kaolin behavior, record rats eating kaolin amount.
2nd, experimental result
Compared with control group, model group rats feed kaolin amount substantially increases (P<0.01).Ondansetron group and this hair
Bright composition can substantially reduce rats eating kaolin amount.It the results are shown in Table 1.
| Group | Kaolin amount (mg) |
| A | 39.8±12.5 |
| B | 1917.3±236.1 |
| C | 1652.7±61.9 |
| D | 1796.2±58.5 |
| E | 1733.8±86.4 |
| F | 1785.0±69.5 |
| G | 1519.2±57.1 |
| H | 1583.6±78.5 |
| I | 1609.4±91.2 |
| J | 1655.0±79.6 |
Test example 2
The clinical efficacy of active components of glossy ganoderma composition treatment Nausea and vomiting effect is summarized
Observation treatment 60 is through the patients undergoing chemotherapy that definitive pathological diagnosis is malignant tumour altogether, wherein man 22, female 8, age
It is 31-78 year, average 51.2 years old.
1 inclusive criteria
MethodsThe cases enrolled meets following condition：Diagnosis clearly needs row combined chemotherapy；Without increased intracranial pressure, intestinal obstruction or other
Without vomiting and not used antiemetic person in intractable vomiting 24h caused by reason；Electrocardiogram, blood routine, liver are checked before chemotherapy
Work(, kidney function, blood sugar effects are normal.
MethodsThe cases enrolled is randomly divided into treatment group and each 30 of control group, two groups of general information no significant difference (P
>0.05), there is comparativity.
2 treatment methods
30min Ondansetron 8mg intravenous injections before control group chemotherapy, continuous injection 3 days, base of the treatment group in control group
Soft capsule made from active components of glossy ganoderma composition in the oral embodiment of the present invention 1 on plinth, take within 1 day before chemotherapy, one day 2
It is secondary, oral 2 every time.
3 treatment results
Criterion of therapeutical effect：With reference to the World Health Organization (WHO) standard (Zhou Jichang practicality intra-tumor science Beijing：The people defend
Raw publishing house, 2000：22-24.), how much it is divided into by nausea and vomiting number effective one by one：Without nausea and vomiting in 24 hours；Effectively：
Nausea or vomiting 2-3 times in 24 hours；It is invalid：Nausea or vomiting in 24 hours>4 times.
As a result：Effective 23 for the treatment of group, effective 5, invalid 2, total effective rate 93.3%；Effective 8 of control group, effectively
10, invalid 12, total effective rate 60.0%.Two groups of total effective rates are compared, the statistically significant (P of difference<0.05).
In summary, the active components of glossy ganoderma composition of the embodiment of the present invention and the suppression chemotherapy institute being thus prepared
Cause its good effect, quick in Nausea and vomiting reaction.
Embodiments described above is part of the embodiment of the embodiment of the present invention, rather than whole embodiments.This hair
The detailed description of the embodiment of bright embodiment is not intended to limit the scope of claimed invention embodiment, but only table
Show the selected embodiment of the embodiment of the present invention.Based on the embodiment in the embodiment of the present invention, those of ordinary skill in the art are not having
There is the every other embodiment made and obtained under the premise of creative work, belong to the scope of protection of the embodiment of the present invention.
Claims (9)
1. a kind of active components of glossy ganoderma composition, it is characterised in that it includes polysaccharide, glycopeptide and ganoderic acid A, the polysaccharide, sugar
Peptide and ganoderic acid A weight ratio are (5-55)：(1.5-15)：(1-8).
2. active components of glossy ganoderma composition according to claim 1, it is characterised in that it also includes ganoderic acid B and/or spirit
Sesame acid C2, the polysaccharide, glycopeptide, ganoderic acid A, ganoderic acid B and ganoderic acid C2Weight ratio be (5-55)：(1.5-15)：(1-8)：
(0.6-6)：(0.5-5).
3. active components of glossy ganoderma composition according to claim 2, it is characterised in that the polysaccharide, glycopeptide, ganoderic acid A,
Ganoderic acid B and ganoderic acid C2Weight ratio be (10-30)：(5-15)：(4-12)：(3-8)：(2-8).
4. active components of glossy ganoderma composition according to claim 2, it is characterised in that the polysaccharide, glycopeptide, ganoderic acid A,
Ganoderic acid B and ganoderic acid C2For ganoderma lucidum and the extract of glossy ganoderma spore powder with crushed sporoderm.
5. active components of glossy ganoderma composition according to claim 2, it is characterised in that the ganoderma lucidum and exosporium-broken spore of glossy ganoderma
The weight ratio of powder is (6-12)：(1-6).
6. active components of glossy ganoderma composition according to claim 3, it is characterised in that the ganoderma lucidum and exosporium-broken spore of glossy ganoderma
The weight ratio of powder is (6-12)：(2-5)；
Preferably, the weight of the ganoderma lucidum and glossy ganoderma spore powder with crushed sporoderm ratio is 2：1.
7. the preparation method of the active components of glossy ganoderma composition described in a kind of claim 2, it is characterised in that it includes following step
Suddenly：
The 30-95% second relative to 5-30 times of raw material gross weight is added in the raw material including glossy ganoderma powder and glossy ganoderma spore powder with crushed sporoderm
Alcohol, refluxing extraction 1-3 times, each 1-8h, filtering, recovery ethanol obtain alcohol extract；Added in the dregs of a decoction after extraction relative to raw material
The water of 5-30 times of gross weight, extract 1-3 times, each 1-5h, filtering, appropriate concentration, obtain water extract；Merge alcohol extract and water extraction
Thing, obtain active components of glossy ganoderma composition.
8. active components of glossy ganoderma composition according to claim 2, it is characterised in that the active components of glossy ganoderma composition
Granule or (soft) capsule can be prepared as.
9. active components of glossy ganoderma composition as claimed in claim 2, the medicine that the Nausea and vomiting caused by suppression chemotherapy is prepared reacts
Application in thing.
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| CN104983751A (en) * | 2015-07-10 | 2015-10-21 | 广西仙草堂制药有限责任公司 | Immunity-boosting ganoderma lucidum health care product and preparing method thereof |
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| CN104983751A (en) * | 2015-07-10 | 2015-10-21 | 广西仙草堂制药有限责任公司 | Immunity-boosting ganoderma lucidum health care product and preparing method thereof |
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| CN108392543A (en) * | 2018-05-08 | 2018-08-14 | 东莞市亚洲制药有限公司 | A kind of health composition and its preparation method and application |
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Application publication date: 20180209 |