JP2011184349A - Frequent urination-ameliorating composition, healthy food and blood flow-ameliorating composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a safe frequent urination-ameliorating composition, and a blood flow-ameliorating composition. <P>SOLUTION: The frequent urination-ameliorating composition contains an essence of basidiomycetes, extracted from the mycelium-cultured product or the carpophore of the basidiomycetes. One kind selected from the group consisting of fungi of family Hydnaceae and Flammulina velutipes (Fr.) Sing. is used as the basidiomycetes. The essence is obtained by extracting the carpophore/mycelium of the basidiomycetes with hot water at 50-80°C or ethanol at 40-60°C, and subjecting the extract to lactobacillus fermentation. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a frequent urination improving agent, a health food, and a blood flow improving composition, and in particular, a frequent urination improving agent, a health food, and a blood flow improving composition containing a fruiting body of a basidiomycete and / or a mycelium extract. Related to things.

Frequent urination means a state in which the number of urinations has increased. Although there are individual differences in the number of urinations, the urine volume of healthy adults is around 1500 mL in 24 hours, and the bladder capacity when urinating is about 250-300 mL. For this reason, the number of normal urinations is generally 4-5 times during the day and 0-2 times at night. That is, the number of urinations is about 5 to 6 times a day.
For this reason, if urination occurs more than 8 times during the day and 3 times or more during nighttime sleep, that is, 10 times or more per day, it can be defined as frequent urination.

Frequent urination occurs for a variety of reasons, and many people suffer from it.
The first cause of frequent urination is a disease that increases urine output (polyuria). Polyuria can be caused by diabetes insipidus, diabetes, some forms of renal failure, and other drugs.
In addition, there is a disease near the bladder, and frequent urination occurs when chronic stimulation is applied to the bladder.
Examples of diseases that cause frequent urination due to bladder irritation include cancerous peritonitis, rectal cancer, and fibroids. Pain such as back pain may irritate the bladder and cause frequent urination.
Other frequent urinations are often due to urinary diseases. Examples of such diseases include renal drooping, urinary tract infection, atrophic bladder, ureteral stone located near the bladder, and the like.
Frequent urination associated with urinary tract infections occurs because, for example, acute cystitis associated with the growth of pathogenic bacteria stimulates urination, and urinary urination always involves urinary pain. In addition, psychogenic frequent urination is also present.

In addition, it is the frequent urination of the elderly that becomes a therapeutic problem. The most frequent frequent urination in the elderly is frequent urination associated with benign prostatic hyperplasia.
Prostatic hypertrophy is a disease in which the urethra is compressed because the prostate surrounding the urethra becomes larger. Prostatic hypertrophy occurs with aging, and is a common symptom, especially in older men, and one in four men over the age of 60 suffers from this disease.
In benign prostatic hyperplasia, symptoms of dysuria and frequent urination occur, which makes it difficult for urine to leave the bladder. Specifically, although it varies depending on the degree of pressure on the urethra, symptoms such as difficulty in urine production and feeling of residual urine appear, and the patient often wakes up in the bathroom at night.
Symptoms of benign prostatic hyperplasia are mainly dysuria, and frequent urination is accompanied by difficulty in urinating.

The cause of prostatic hypertrophy is not clear, but the balance between male and female hormones is thought to be a cause. In addition, a prostatic hypertrophy nodule, which is one of the aging phenomena generally seen in men since their late 40s, is also considered to be a factor of hormonal balance disruption.
In addition, dysuria appears in the early stages of prostate cancer as well as prostatic hypertrophy. When prostate cancer grows to a certain extent, the urethra is compressed, causing symptoms similar to benign prostatic hyperplasia such as difficulty urinating, frequent urination, and residual urine sensation.
Prostate cancer is the most common cancer in the United States, accounting for the top number of male cancer deaths. In Japan, the number of patients has increased rapidly in recent years due to changes in lifestyle habits, which has become a major medical problem.
The onset of prostate cancer correlates with animal fat overdose and is said to be affected by lifestyle habits.
It is generally recognized that when prostate enlargement progresses, it shifts to prostate cancer. However, it has been found that there is not much correlation between prostate enlargement and prostate cancer.

As described above, the cause of frequent urination is derived from diseases of urinary organs such as the bladder and prostate, while the frequent urination occurs without clear cause. For women, it has been found that the frequency of frequent urination increases with age.
Regardless of the cause, frequent urination is an illness and treatment is essential because it reduces the quality of life (QOL).
Here, conventionally, a frequent urination agent using a natural plant-derived component has been used for frequent urination whose cause is not clear.

The following are known as these conventional plant-derived components:
・ Saw Palmetto (SAWPALMETTO, Saw Palmetto)
It is a plant belonging to the genus Palmera, which is distributed from the southern part of the United States to Mexico, and is called the selenoa repens by scientific name. In France, Germany, etc., saw palmetto preparations have been distributed as pharmaceuticals for over 60 years, and it has been reported that enlargement of the prostate, pain, and difficulty in draining have improved.
-Pepo Pumpkin Pepo Pumpkin (C. pepo type pumpkin) is a medicine for preventing symptoms such as urinary incontinence, benign prostatic hyperplasia and prevailing hypersensitivity in women and urinary incontinence, and is widely used in Europe. There are reports that some peppo pumpkin seeds contain ingredients that help improve urination problems.
-Ginkgo biloba extract An extract obtained by drying ginkgo biloba leaves and extracting with ethanol. Ginkgo biloba was first used to treat human frequent urination in China in the early 16th century. In the middle of the 20th century (1965), Ginkgo biloba extract was registered as a medicine in Germany. Ginkgo biloba extract is currently handled as a general food (health food) in Japan under the Food Sanitation Law. However, it is distributed as a medicine in 55 countries including Germany.

Moreover, as a frequent urinary remedy using a plant-derived component, referring to Patent Document 1, it contains coconut, osseous fat and perilla leaves as main components. Health foods are described (hereinafter referred to as Prior Art 1).
The eggplant in the prior art 1 is a seed of a perennial plant of the lily family, so-called leek (Allium tuberosum Rottler). Prosthetic fat is obtained by drying the mature fruit of the leguminous Dutch apricot (Psoralea corifolia L.). Perilla is a perillafrenchescens briton var. Acuta Kudo foliage is dried.
Since the health food of Prior Art 1 is a mixture of components that are harmless to the human body, it can be used regularly on a daily basis and can alleviate symptoms of frequent urination. Moreover, the health food of the prior art 1 is effective not only for frequent urination but also for relieving chilliness.

JP 2005-160356 A

  However, the health food of the prior art 1 is merely a combination of conventional plants for improving frequent urination, and has no effect over the combination of these components in improving frequent urination.

  This invention is made | formed in view of such a condition, and makes it a subject to eliminate the above-mentioned subject.

The composition for improving frequent urination according to the present invention is characterized by comprising an extract of the basidiomycetes extracted from the fruiting bodies of the basidiomycetes and / or mycelium cultures.
The composition for improving frequent urination according to the present invention is characterized in that the basidiomycete is one selected from the group consisting of a fungus of the family Hyderaceae and Flammulina Velutipes (Fr.) Sing. .
The composition for improving urinary frequency according to the present invention is characterized in that the extract is obtained by fermenting a fruit body and / or mycelium culture of the basidiomycete.
In the frequent urination improving composition of the present invention, the extract is an extract obtained by hot water extraction of the fruiting body and / or mycelium culture of the basidiomycete at 50 to 80 ° C. or ethanol at 40 to 60 ° C. It is characterized by that.
The health food of the present invention is characterized in that it contains the frequent urination improving composition.
The health food of the present invention is characterized by further adding an extract of mannenderma lucidum (Leyss. Ex. Fr.) Karst.
The composition for improving blood flow of the present invention comprises an extract extracted from a fruiting body of a basidiomycete and / or a mycelium culture.
The composition for improving blood flow according to the present invention is characterized in that the basidiomycete is one selected from the group consisting of a fungus of the family Hyderaceae, Flammulina Velutipes (Fr.) Sing. .

  According to the present invention, by including a mycelium extract extracted from the fruiting body of a basidiomycete and / or mycelium culture, the frequent urination improving composition and the blood flow improving composition having a high effect of improving frequent urination, Can be provided.

It is a flowchart of the manufacturing method of the lactic-acid-bacteria fermented extract powder of the Yamabushitake fruiting body and / or mycelium which concern on embodiment of this invention. It is a table | surface which shows the result of the administration test of the frequent urination improving composition which concerns on embodiment of this invention.

<Embodiment>
Since ancient times, basidiomycetous fruit bodies (茸) have been edible, and some have been heavily used as traditional Chinese medicines. Furthermore, various methods for producing health foods for extracting active ingredients from such basidiomycetes have been disclosed.
As one of the basidiomycetes used as such herbal medicines and health foods, there are Hydanaceae bacteria such as Yamabushitake.
Yamabushitake is a mushroom belonging to the coral relicaceae family, with the scientific name (Hericium erinaceum (Fr.) Pers.) And the Japanese name "Yamabushi". This fungus is a kind of wood-rotting fungus that occurs in hardwood standing trees and rot trees.
Yamabushitake is widely distributed in the northern hemisphere of Japan, China, the United States, Europe, etc. and has been edible in various places since ancient times. In China, the shape is called monkey head measure (蕗 means samurai), and in Japan, it is called Yamabushitake, which is like a round ornament attached to a ligature worn by Yamabushi.

This Yamabushitake extract (extract) has traditionally had anticancer effects, constipation prevention, obesity, diabetes, prevention of arteriosclerosis, promotion of elimination of toxic substances in foods, improvement of self-protection, etc. Have been reported to have various effective effects.
Specifically, ordinary basidiomycetes contain only one or two types of physiologically active polysaccharides, whereas Yamabushitake has a hetero-β-D-glucan with five types of antitumor activity. All of which show high anti-therapeutic activity.
Among them, “Manno gloxy silane” and “Galactoxyloglucan” are unique polysaccharides that are only contained in Yamabushitake, and have been found to have a high tumor healing rate compared to other basidiomycetes. Yes.
And it is said that the health food using the extract of this Yamabushitake fungus has blood pressure lowering action, diuretic action, fatigue recovery action, anticancer action, antidiabetic action, constipation prevention, antiallergic action and the like.

Yamabushitake is said to be effective in revitalizing the brain in China. Even now, it is said that Yamabushitake is used regularly as a measure for taking the examination. This is thought to be because Yamabushitake-specific components, helicenone, and erinasin act on neurons in the brain and activate information transmission.
In addition, as will be described later, Yamabushitake has an action of promoting the secretion of NGF (nerve growth factor), which is an important protein that promotes the recovery of cranial nerve function and prevents aging. Has been shown by the inventor. NGF is also known to be used for promoting synthesis of neurotransmitters, elongating nerve axons, repairing axonal damage, maintaining nerve cells, and the like.

  However, in addition to the effects as described above, there are many cases where the extract of basidiomycetes containing yamabushitake has not yet been known.

Therefore, the inventors of the present invention have made extensive studies on the pharmacological action of mycelium extracts of basidiomycetes that have been edible and used in traditional Chinese medicine.
Surprisingly, the extracts of mycelium or fruiting bodies of some basidiomycetes, including the genus Haritake family, Yamabushitake, surprisingly improve urination problems (such as frequent urination and urine leakage) and improve blood flow. As a result, the present invention has been completed.
This improvement in urination trouble and blood flow improvement is effective for both men and women from young to old.

The extract of basidiomycetes according to the embodiment of the present invention can improve frequent urination and further improve blood flow and the like.
In addition, Yamabushitake has originally been established as a food and has no toxicity. Therefore, it is possible to provide a composition that is excellent in safety with no fear of side effects and effective in improving frequent urination and blood flow.

<Frequent urination improving composition according to an embodiment of the present invention>
Here, the composition and manufacturing method of the frequent urination improving composition and the blood flow improving composition according to the embodiment of the present invention will be specifically described.
The composition for improving frequent urination and the composition for improving blood flow according to the present embodiment are characterized by including an extract of basidiomycetes extracted from a fruiting body / mycelium culture of basidiomycetes.
Examples of the basidiomycetes include fungi of the family Azalea (hereinafter, Yamabushitake is used as an example), Lentila edodes (Berk.) Sing., Enoki mushroom (Flamulina Velutipes (Fr.) Sing.) And the like.
In this embodiment, as the mycelium extract of this basidiomycete, it is desirable to use an extract of fruit bodies and / or mycelium extracted with hot water at 50 to 80 ° C. or extracted with ethanol at 40 to 60 ° C. .
Moreover, in this embodiment, it is desirable that the mycelium extract of this basidiomycete is an extract subjected to lactic acid bacteria fermentation.

  If such a frequent urination improving composition and a blood flow improving composition are taken orally, for example, regardless of age or sex, urination problems such as frequent urination and urine leakage due to various causes can be remarkably improved. Furthermore, abnormalities in blood flow can be improved, and there is no risk of side effects and safety is excellent.

[Frequent urination and blood flow improving composition made from Yamabushitake]
Hereinafter, the frequent urination improving composition and the blood flow improving composition according to the present invention will be described more specifically.
The composition for improving frequent urination and the composition for improving blood flow according to the present invention include a mycelium extract of basidiomycetes.

  Basidiomycota has been edible as an edible fungus in Japan since ancient times, and pine mushrooms or agarices mushrooms that have been used in traditional Chinese medicine include matsutake mushrooms (Tricholoma Matstake Ito et Imai.), Shiitake mushrooms Lentinula edodes (Berk.) Sing.), Enoki mushrooms (Flamulina Velutipes (Fr.) Sing.), Pleurotus ostereats (Jacq. Ex Fr) Kummer, Nameko (Pholioto. Meiko). IMAI), Iguchi (Boletus Dill. Ex Fr.), Shimeji (Lyophyllum shijiji (Kawam) ) Hongo), lactifluus volemus (Lactarius volemus (Fr.) Fr.), Pleurotus eryngii (Pleurotus eryngii), and the like.

  In addition, examples of the moths of the order of Sarnobacteria (Aphyllophorales) include Elfvingia applanatas (Pers.) Karst. Quel.), Mannen mushroom or Ganoderma lucidum (W. Curt. Ex Fr.) Karst., Maiko (Grifola frontosa (Fr.) SF Gray, P. yucatensis (Murr.) Imaz.,) And the like.

  Examples of the moths of the order of the jellyfish (Auriculariales) or Tremellales (Auricularia auriculara (Hook.) Underw.), The white jellyfish (Tremellenea fuciformis Berk.) And the like. Examples of moths of canthalales include Yamabushitake of Haritake department, that is, Hydnum.

Of these basidiomycetes, the frequent urination and blood flow improving composition according to the embodiment of the present invention uses a bacterium belonging to the genus Hericium of Hydnaceae, in particular, H. erinaceus. Particularly preferred.
In addition, shiitake mushrooms and enoki mushrooms are also preferably used based on preliminary experimental results.
In the composition of the present embodiment, these basidiomycetes can be used alone or in combination of two or more.
Many of these basidiomycetes are “Mushroom Encyclopedia” (Katsuya Nakamura, Asakura Shoten, 1989), “Mushroom Cultivation Method” (Iwade Shinnosuke, Geo-sha, 5th edition 1985) or It is described in detail in "Primary Color Japanese Fungi Encyclopedia" (Imoseki et al., Childcare Company, 1983, 27).

When producing the frequent urination improving composition and the blood flow improving composition according to the present embodiment, there is no particular limitation on the method for producing a basidiomycete mycelium extract such as Yamabushitake mycelium extract.
For example, in the Yamabushitake mycelium extract, it is preferable to use a powder obtained by subjecting a Yamabushitake mycelium culture to lactic acid bacteria fermentation and freeze-drying. Alternatively, the fruit body of Yamabushitake can be powdered and fermented with lactic acid bacteria.

In the frequent urination improving composition and blood flow improving composition of the present embodiment, particularly preferably in terms of frequent urination and blood flow improving effect, the Yamabushitake extract is 50-80 ° C. hot water extraction or 40-60 ° C. It is desirable to use an extract extracted with ethanol. Moreover, it is desirable that the extract is fermented with lactic acid bacteria.
In addition, other basidiomycete mycelium extracts other than the Yamabushitake fungus extract can be prepared by the same production method as the Yamabushitake fungus extract.

[Manufacturing method of lactic acid bacteria fermented extract powder of Yamabushitake fruit body and / or mycelium]
Here, with reference to FIG. 1, the example which prepares the extract (Yamabushitake fungus extract) extracted by lactic acid bacteria fermentation of a Yamabushitake fruit body or a mycelium is demonstrated.

(Step S101)
To prepare the Yamabushitake fungus extract of the present embodiment, specifically, fruit body / mycelium pulverization treatment is first performed.
Specifically, dried fruit bodies and / or mycelia of the fungi of the family Amanita are pulverized with a pulverizer and mixed well with 10 to 50 times the weight of water, preferably pure water or ethanol. On this, in the case of water, it heats to 50-80 degreeC and extracts an extract. Moreover, in the case of ethanol, it extracts at 40-60 degreeC. After extraction, freeze-drying is performed to obtain a powder.
In this pulverization step, for example, a pulverizer capable of forming a fine powder without degrading pharmacological activity, such as a homogenous pulverizer, can be used.
Further, the crushed fruit body / mycelium can be used as it is without performing extraction.

(Step S102)
Next, a lactic acid bacteria solution adjustment process is performed. Specifically, eubacteria that are eubacteria used for lactic acid bacteria fermentation, such as Lactobacillus lactic acid bacteria, Lactobacillus reuteri, Lactobacillus plantarum, Lactobacillus casei, etc., and e. For example, it prepares from the state preserve | saved by freezing etc. to the state used for fermentation.

(Step S103)
Next, a specific fermentation treatment is performed to obtain a Yamabushitake fungus extract stock solution.
Here, for example, the ground Yamabushitake fruit body / mycelium powder obtained in Step S101 described above and the lactic acid bacteria liquid obtained in Step S102 with respect to water have the following weights, for example: % To prepare and ferment.

Yamabushitake powder 10% -70%
Glucose 1%
Yeast crushed 1%
Lactic acid bacteria solution 0.2%

These are fermented with lactic acid bacteria at 35 ° C. to 37 ° C. for about 2 days to 72 hours to obtain a Yamabushitake mushroom extract stock solution.

(Step S104)
Next, freeze pulverization is performed.
Specifically, the Yamabushitake fungus extract stock solution obtained in step S103 can be freeze-dried in vacuum to obtain a powder. By pulverizing this powder with a pulverizer, the lactic acid bacteria fermented extract powder of this embodiment can be obtained.
About 200 to 250 mg of this lactic acid bacteria fermented extract powder is enclosed in a capsule that can be taken orally.

The unpulverized powder / pulverized lactic acid bacteria fermented extract powder can be made into a paste using excipients, tableted with a tableting machine, or directly into health foods, etc. is there.
Furthermore, the above-mentioned Yamabushitake fungus extract stock solution itself can be heat sterilized and the like, and can be prepared as a health drink by adding sugar, flavoring, preservatives and the like. Furthermore, the Yamabushitake fungus extract thus obtained can be used after being concentrated, or it can be further freeze-dried and used in the form of a powder.
Moreover, the powder of the extract of the agaric family extracted with hot water or alcohol can also be used as it is not fermented with lactic acid bacteria.

  As mentioned above, although the example of the preferable preparation method of a Yamabushitake fungus extract was explained in detail, the above-mentioned other basidiomycete mycelium extracts used in the present invention can also be replaced with the above-mentioned Yamabushitake, Ganoderma, Enoki mushroom, Meshimakobu, Yamabushitake, Maitake It can be prepared in the same manner as in the above preparation method except that basidiomycetes such as eringi are used.

Moreover, in this embodiment, these basidiomycetous extracts can be used as a frequent urination improving composition and a blood flow improving composition.
In the frequent urination improving composition and the blood flow improving composition according to the embodiment of the present invention, basidiomycete mycelium extract such as Yamabushitake extract may be contained in any amount.
Such a frequent urination improving composition and a blood flow improving composition may be orally administered in various dosage forms such as granules, liquids, tablets, and capsules. It can also be used by adding to an injection solution used for persons with frequent urination and abnormal blood flow improvement.
In addition, the Yamabushitake extract stock solution can be directly administered to persons with frequent urination and abnormal blood flow without dilution. In addition to this, for example, it can be administered after appropriately diluted with purified water, physiological saline, alcohol or the like.

Here, as the reason why the Yamabushitake fungus extract improves frequent urination, the following reasons are considered as hypotheses.
Conventionally, it has been known that sleep ability declines due to brain function deterioration mainly due to aging. Frequent urination other than prostate irritation and urinary illness can also be caused by some decrease in brain function due to aging.
Conventionally, it has been discovered that dementia is altered when NGF (nerve growth factor) is administered into the brain.
As described above, Helenonone D and Erinacin C, which are contained in a large amount in Yamabushitake, have been confirmed to have NGF synthesis promoting activity and act on neurons in the brain to suppress dementia and enhance memory ability. Is expected.
However, conventionally, the improvement effect of frequent urination by NGF has not been known.
In addition, Yamabushitake extract contains an unknown component that activates nerves, and there is a possibility that it may have a remarkable effect of repairing and adjusting a part of the brain related to frequent urination. It is also possible that the function of the autonomic nervous system is adjusted to make it less likely to cause frequent urination.
For this reason, the frequent urination improving composition and the blood flow improving composition of the embodiment of the present invention are not only elderly men with prostatic hypertrophy, but also women and young patients with urination troubles such as frequent urination and urine leakage, It can be inferred that it is effective for patients with coldness.
From preliminary experiments, it has been found that the Yamabushitake fungus extract of this embodiment is also effective for so-called “rice cakes” of children and urine leakage of women due to childbirth and the like.

Furthermore, preliminary experiments have shown that the frequent urination improving composition and blood flow improving composition containing the Yamabushitake extract extract have a blood flow abnormality improving effect in addition to the frequent urination improving effect.
According to the study by the present inventors, the frequent urination improving composition and the blood flow improving composition containing basidiomycete extracts such as Yamabushitake extract are extracted from the fruiting bodies / mycelium of Basidiomycetes such as Yamabushitake. Many active ingredients extracted from a solid medium in which basidiomycetes such as Yamabushitake are cultured. And it is thought that these unidentified components act comprehensively and improve not only frequent urination but also abnormal blood flow. In addition, it seems that survival can be extended by improving metabolism.

  As described above, the composition according to the embodiment of the present invention can improve frequent urination, further improve abnormal blood flow, and also has a health food (healthcare) with no side effects and excellent safety. Food), or pharmaceuticals such as frequent urination and a blood flow abnormality-improving agent.

To add further here, according to a survey by the Ministry of Health and Welfare, one out of four men over the age of 60 in Japan is suffering from this disease. Frequent urination is one of the illnesses and treatment is essential because it reduces the quality of life (QOL). Also, frequent urination is a very big problem for women.
In addition, excess carbohydrates and lipids that flow in the blood are deposited on the blood vessel wall, inducing inflammation due to infiltration of inflammatory lymphocytes and platelets, and causing arteriosclerosis, which is a cause of ischemic disease.
Heart disease and stroke (blood flow abnormality), which are ischemic diseases, are counted among the three leading causes of death in Japan. In order to treat and prevent these diseases, the development of blood flow improving agents, which are considered to be important to improve and prevent blood flow, is significant.

In addition, as described above, some Yamabushitake bacteria have an antitumor effect, so that, for example, it can improve the QOL of a patient suffering from a disease such as prostate cancer, and at the same time, can survive for a long time. An effect is obtained. Furthermore, it has been found from preliminary experiments that Yamabushitake extract also has an effect of improving immunity.
In the prior art 1, propolis, which is also known for its anticancer effect, was added, but the Yamabushitake fungus extract of the present embodiment does not need this, and therefore the cost can be reduced.

In addition, the fermented extract powder of lactic acid bacteria of the present embodiment is obtained by fermenting the fruit body / bacteria of Yamabushitake with lactic acid bacteria, so that lactic acid produced by lactic acid bacteria includes polysaccharides such as β-glucan, helicenone, erinasin and other Yamabushitake The effect that an original component melt | dissolves and an absorptivity improves is acquired.
This lactic acid bacteria fermented extract powder can be ingested with metabolites of lactic acid bacteria and becomes an anti-aging composition useful for improving the intestinal environment.

In addition, it is also possible to add the extract of other basidiomycetes to the Yamabushitake extract of this embodiment. For example, by adding an extract of mannenderma lucidum (Leyss. Ex. Fr.) Karst, the anticancer effect and the metabolic improvement effect can be further enhanced.
Furthermore, when an extract of shiitake mushroom (Lentinula edodes (Berk.) Sing.) Or enoki mushroom (Flamulina Velutipes (Fr.) Sing.) Is used, it can be used as a glucolipid metabolism abnormality improving agent. Furthermore, it can also be used as a composition for improving abnormal carbolipid metabolism containing an extract of basidiomycetes such as shiitake mycelium extract.

  EXAMPLES Hereinafter, although this invention is demonstrated further more concretely based on an Example, this invention is not restrict | limited by these Examples.

[Example 1]
The fruit body of 1 kg yamabushi buds was made into powder, 10 L of water was added, Lactobacillus reuteri was inoculated at 1% by weight and cultured at 37 ° C. for 2 days. Then, it freeze-dried and it was made into the powder form and obtained the lactic-acid-bacteria fermented extract powder of the Yamabushidatake fungus extract. 200 mg of this lactic acid bacteria fermentation extract powder was packed into a capsule.

[Administration test of lactic acid bacteria fermentation extract powder]
With reference to FIG. 2, the result of the administration test which investigated the improvement effect of frequent urination using the capsule of the lactic-acid-bacteria fermented extract powder of Example 1 is demonstrated.
First, as a control, the number of urine was observed for 2 days before using the above-mentioned capsules for 13 subjects (age 46 to 72 years) of subjects A to M who have subjective symptoms of frequent urination. Here, first, the number of urinations was counted by dividing into two hours before the start of drinking, morning, afternoon, evening, and time zone after going to bed.
Thereafter, subjects A to M were allowed to drink 5 capsules (1000 mg) of the lactic acid bacteria fermented extract powder of Example 1 per day, night, and before going to bed. Thereafter, the number of urinations for 3 days from the 10th day to the 12th day from the start of drinking was counted.

In FIG. 2, the result about each of test subjects A-M is shown.
The frequency of urine on the 2nd day before drinking the lactic acid bacteria fermented extract powder, which is a control, for each subject is shown as an average value (see FIG. 2, “before”).
After drinking the lactic acid bacteria fermented extract powder of Example 1, the average value of the maximum value and the minimum value was described (see FIG. 2, “After”).

About subjects A to M, after drinking the lactic acid bacteria fermented extract powder of Yamabushitake of Example 1, the number of urination from the 10th day was counted, and as a result, the number of times decreased in all subjects.
As is clear from the comparison between before and after use of this test group, the tendency to improve frequent urination is observed when the fermented lactic acid bacteria powder of Yamabushitake is administered.
This exceeds the effect of the frequent urination improving agent of Prior Art 1. That is, the fermented lactic acid bacteria extract of Example 1 has a remarkable frequency urinary inhibitory effect regardless of the frequency amelioration improving composition using a highly safe food.

As described above, in the present embodiment, the fruit body / mycelium of basidiomycetes containing Yamabushitake fungus is effective by lactic acid bacteria fermentation extract using 50-80 degree hot water extraction and 40-60 degree ethanol extract. A high frequency urination improving composition and a blood flow improving composition can be provided.
That is, the basidiomycete lactic acid bacteria fermented extract of the present embodiment provides a safe and highly effective urinary frequency improving composition for sick people suffering from urination problems such as frequent urination and urine leakage, regardless of gender. This results in improved QOL at the individual level and reduced medical costs at the social level.
Further, the basidiomycete lactic acid bacteria fermented extract of the present embodiment provides a blood flow improving composition that is a blood flow improving effect and a means for preventing diseases caused by vascular abnormalities.
In addition, the basidiomycete lactic acid bacteria fermentation extract of this embodiment can be used as a health food or a medicine.

  Note that the configuration and operation of the above-described embodiment are examples, and it is needless to say that the configuration and operation can be appropriately changed and executed without departing from the gist of the present invention.

  According to the present invention, by using a basidiomycete extract, a composition for improving frequent urination that is safe and highly effective for a sick person suffering from urination problems such as frequent urination and urine leakage, and a blood flow improving composition are provided. can do. These compositions can be manufactured and sold as health foods.

Claims (8)

A composition for improving frequent urination, comprising an extract extracted from a fruiting body of a basidiomycete and / or a mycelium culture. The composition for improving frequent urination according to claim 1, wherein the basidiomycete is one selected from the group consisting of a bacterium of the family Hydnaceae and Flammulina Velutipes (Fr.) Sing. object. The composition for improving frequent urination according to claim 2, wherein the extract is obtained by fermenting a fruiting body and / or mycelium culture of the basidiomycetes with lactic acid bacteria. The extract is an extract obtained by hot water extraction of the fruiting body and / or mycelium culture of the basidiomycetes at 50 to 80 ° C or ethanol extraction at 40 to 60 ° C. The frequent urination improving composition described in 1. A health food comprising the frequent urination improving composition according to any one of claims 1 to 4. The health food according to claim 5, further comprising an extract of Ganoderma lucidum (Leyss. Ex. Fr.) Karst. A composition for improving blood flow, comprising an extract extracted from a fruiting body of a basidiomycete and / or a mycelium culture. The composition for improving blood flow according to claim 7, wherein the basidiomycete is one selected from the group consisting of a bacterium belonging to the family Hydnaceae and Flammulina Velutipes (Fr.) Sing. object.

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