CN107156332A - A kind of complex health care product of strengthen immunity - Google Patents
A kind of complex health care product of strengthen immunity Download PDFInfo
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- CN107156332A CN107156332A CN201710481064.1A CN201710481064A CN107156332A CN 107156332 A CN107156332 A CN 107156332A CN 201710481064 A CN201710481064 A CN 201710481064A CN 107156332 A CN107156332 A CN 107156332A
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- health care
- care product
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- complex health
- seed oil
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of complex health care product of strengthen immunity.A kind of complex health care product of strengthen immunity, is mainly made up of following component：By weight, 300 500 parts of Seabuckthorm Seed Oil, 50 150 parts of Boxthorn Seed Oil, 30 100 parts of ganoderma lucidum spore oil, 20 70 parts of gadol extract, 0 20 parts of vitamin e1.The coordinated that the complex health care product of the present invention passes through various materials; start with from multiple dimensions such as blood, blood vessel, the object removed, protection immunocyte, activating immune system, elimination superoxide radical, the oxygen-enriched abilities of offer; blood circulation system, the undesirable element in immune system and the cancer activity factor of human body are eliminated comprehensively; carry out bidirectional modulation; lift blood circulation system and the physiological function of immune system; and it is at good operating condition; the immunity of human body is drastically increased, significant antitumaous effect has been played.
Description
Technical field
The present invention relates to health product technology field, more particularly, to a kind of complex health care product of strengthen immunity.
Background technology
Immunity is the defense mechanism of human body itself, is that human bioequivalence and any foreign matter for eliminating external intrusion are (viral, thin
Bacterium etc.), processing aging, damage, death, the own cells of denaturation, and identification and processing vivo mutations cell and virus are infected
The ability of cell is human bioequivalence and excludes the physiological reaction of " dissident ".Most of disease of the mankind all with it is immune relevant, it is common
Autoimmune disease also have endocrine autoimmune disease, systemic rheumatism, haematogenic immunity disease, cutaneous immunisation disease
Disease, digestive system immunity disease and kidney immunity disease, such as allow the leukaemia of people's " hearing sickly complexion to become ", is exactly that blood is exempted from
One kind in epidemic disease.
In addition, research shows that cancer and immunity have certain indirect relation.Body immunity can effectively remove one when high
A little necrosis, malignant cell, removing toxins in human body, the function with " removing rubbish ", so for, the high people of immunity, energy
Part of cancerous cell is killed in the resistance of oneself effective, controls the further development of cancer cell.
Modern medical science also found, the factor of immune to be one have with aging substantial connection, and immunocyte decline is to decline
One of old most important reason.Some special cells of body immune system can by the bacterium in invasion body, virus and in vivo
The cell of aging death, the cell being mutated and the material for causing allergy, are wholly swallowed and are eliminated, from internal
The stabilization of environment, keeps body health.But body's immunity began to decline at 30 years old or so, this change is quietly, delayed
Slowly, it is continued for.
It can be seen that, either for which aspect, improve autoimmunity all most important to health.Grass in natural drug
Medicine is the material that the mankind apply earliest, and China's traditional medicine increasingly payes attention to improving the research and application of immunity medicine.State
Interior scholar proves that the extract in Fuzheng herbs such as the Radix Astragali, ginseng, wilsonii, umbellate pore furgus, white fungus and rainbow conk has obvious in recent years
Immunological enhancement, macrophage phagocytic function can be promoted, enhancing T cell vigor and antibody are formed, be the anti-of significant
Old medicine.However, there are 12807 kinds of natural Chinese medicinal herb resources in China, and it is conventional, different Chinese herbal medicine to machine wherein there was only 10%
The influence emphasis of body immune system is also different, it is still necessary to which further investigation is utilized.Therefore, in order to improve the immune of people
The health products that power is preferably used to strengthen immunologic function there is provided new, effect are that this area technology urgently to be resolved hurrily is asked
Topic.
In view of this, it is special to propose the present invention.
The content of the invention
It is an object of the invention to provide a kind of complex health care product of strengthen immunity, described complex health care product passes through section
Compatibility relationship, each component acts synergistically, and with more significant immunity enhancing effect and anticancer effect, and draws materials
Naturally, without any toxicity and side effects.
In order to realize the above object the invention provides following technical scheme：
A kind of complex health care product of strengthen immunity, is mainly made up of following component：By weight,
Wherein, Seabuckthorm Seed Oil contains multivitamin, flavonoids, aliphatic acid, amino acid and other trace elements, to heart and brain
Blood vessel, metabolism and immune system, digestive system and liver have health-care effect, and have certain suppression to cancer cell and kill
Wound is acted on, and has functions that to alleviate radiation injury.
Boxthorn Seed Oil contains abundant and comprehensive bioactive substance and oleic acid, linoleic acid, gamma linoleic acid, β carrots
Element, SOD etc..Boxthorn Seed Oil has obvious effect to regulation blood fat, liver-nourishing and eyesight-improving, kidney tonifying anticancer.
The triterpenes ganoderic acid that ganoderma lucidum spore oil contains has strong pharmacological activity, has protect liver, removing toxic substances, kills cancer cell
And pain-relieving functions.Unrighted acid that ganoderma lucidum spore oil contains can pre- preventing thrombosis and artery sclerosis, reduce malignant cholesterol, net
Change blood, eliminate free radical.Organic germanium contained by ganoderma lucidum spore oil has decompression, diuresis, analgesic effect, induces and promotes huge
The phagocytosis of phagocyte.Ganoderma lucidum spore oil suppresses the propagation of tumour cell by activated NK, and can be with bidirectional modulation
The immune system of human body.
Gadol extract mainly lipid containing phenylpropyl alcohol and flavonoid class, its unique active chemical components to human body by exempting from
The direct specific stimulation of epidemic disease defence, searches for and destroys the infected cell of body.Gadol extract can also improve human body spirit
State, the melancholy sense of reduction improves hemochrome and red blood cell level in muscle fat ratio and lifting blood, improves sexual function of human body,
Strengthen memory.Gadol extract also has adaptive significances and dual regulation, and energy bidirectional modulation nervous centralis resists and lacked
Oxygen radiation proof restoration and protection body.
Vitamin E is that life continues one of required nutrient.It can promote sex hormone to secrete, and improve fecundity, protect
T lymphocytes, protection red blood cell, Green Tea Extract oxidation are protected, the lipid peroxidation reaction in ocular lens body can be suppressed, make peripheral blood
Enlargement of pipe, improves blood circulation.
The present invention five kinds of compositions from more than, the proportioning composition complex health care product through science, can not only reach and be protected than existing
The medicinal material or auxiliary of any toxic side effect is not introduced in the strong more significant strengthen immunity effect of product, and the formula of the present invention
Material, therefore be used for a long time safer.
Specifically, in the present invention, Seabuckthorm Seed Oil has the effect for improving Abwehrkraft des Koepers and suppressing cancer cell factor activator,
Boxthorn Seed Oil is except that can remove the rubbish in blood, moreover it is possible to reduce vascular wall cholesterol deposition, prevent blood fat Atherosclerosis
Change, the triterpenes aliphatic acid in linoleic acid, leukotrienes and ganoderma lucidum spore oil, unrighted acid, organic germanium in Boxthorn Seed Oil
Cooperated together with GL-B, with extremely strong reducing blood sugar and blood lipid, eliminate free radical, stimulation of host non-specific resistance and two-way
Adjust rhodioside and Jujubogenin tyrosol in the effect of immune system, gadol extract, network plug to tie up, mainly by directly stimulating
Immune system, immune cell activated, to strengthen the immunologic function of human immune system.It can be seen that, the health products group that the present invention is provided
In compound, the emphasis of each component is different, but by the coordinated of various materials, from blood, blood vessel, pair removed
As, protection immunocyte, activating immune system, eliminate superoxide radical, multiple dimensions such as oxygen-enriched ability are provided started with, disappear comprehensively
Except the undesirable element and cancer activity factor in the blood circulation system of human body, immune system, bidirectional modulation is carried out, blood is lifted
The physiological function of fluid circulation and immune system, and good operating condition is at, drastically increase human body
Immunity, has played significant antitumaous effect.
Formula can also further optimize above, to obtain more preferable immunity enhancing effect, and for example formula is：
Oily composition has a major impact to the health-care effect of formula in all formulas described above, in order to improve health care effect
The oil of fruit preferably following quality：
Preferably, the Seabuckthorm Seed Oil includes following component：Weight percentage,
Protein >=16%, vitamin E 1.35%-2.51%, linoleic acid >=12% and leukotrienes >=10%.
The Seabuckthorm Seed Oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super to face
The temperature that boundary's extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, seabuckthorn seeds are after ultramicro grinding, and the particle diameter of sea-buckthorn powder of seeds is less than 100 μm, and powder diameter is uniform, carefully
Cell wall is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2The temperature that supercritical extraction is used
For normal temperature, seabuckthorn seeds are in CO2Atmosphere in, should under the conditions of can ensure that the active component in seabuckthorn seeds is particularly temperature sensitive
Active material and oxidizable active material do not degraded by high-temperature oxygen, and the recovery rate of active component is high, obtains
Seabuckthorm Seed Oil quality better.
Preferably, the Boxthorn Seed Oil includes following component：Weight percentage, linoleic acid >=61.5%, α-Asia
Numb acid >=3.1%, gamma-Linolenic acid >=3.0%, vitamin E >=0.452% and selenium >=0.44/100000.
The Boxthorn Seed Oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super to face
The temperature that boundary's extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, matrimony vine seed is after ultramicro grinding, and the particle diameter at matrimony vine seed powder end is less than 100 μm, and powder diameter is uniform, carefully
Cell wall is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2The temperature that supercritical extraction is used
For normal temperature, matrimony vine seed is in CO2Atmosphere in, should under the conditions of can ensure that the active component in matrimony vine seed is particularly temperature sensitive
Active material and oxidizable active material do not degraded by high-temperature oxygen, and the recovery rate of active component is high, obtains
Boxthorn Seed Oil quality better.There is low recovery rate, dissolvent residual, active component destructible in squeezing, the organic solvent extraction of routine
The problems such as, and CO of the present invention2Supercritical extraction process completely avoid problem above.
The ganoderma lucidum spore oil includes following component：Triterpenes aliphatic acid, unrighted acid, organic germanium and ganoderma lucidum are more
Sugar.
The ganoderma lucidum spore oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super
The temperature that critical extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, Reishi sporule is after ultramicro grinding, and the particle diameter of Reishi sporule powder is less than 100 μm, and powder diameter is equal
Even, cell membrane is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2What supercritical extraction was used
Temperature is normal temperature, and Reishi sporule is in CO2Atmosphere in, should under the conditions of can ensure in Reishi sporule active component be particularly pair
Temperature sensitive active material and oxidizable active material are not degraded by high-temperature oxygen, and the recovery rate of active component
Height, obtained ganoderma lucidum spore oil quality better.
There is low recovery rate, dissolvent residual, active component in squeezing, the organic solvent extraction of routine, and
CO of the present invention2Supercritical extraction process completely avoid problem above.
Wherein, degumming, depickling for example can add alkali depickling (to be determined with crude oil acid value after alkali number, plus alkali using conventional means
Need to stir 10 minutes with 90rpm speed), heating is needed in deacidification, and heating rate preferably is 1 DEG C/min.
Gadol extract used above can also use conventional extracting method, but preferably following extraction process：
Multiple to the backflow extraction of rhodiola root rhizome using 80-85% ethanol as solvent, temperature during backflow extraction is every time
80-90 DEG C, solid-to-liquid ratio be 1:4-6 (weight ratio)；Concentrate afterwards, then intake air temperature be 150-155 DEG C, outlet temperature be
It is spray-dried under conditions of 90-95 DEG C.
The gadol extract purity that this technique is extracted is high, and obtained Proportion of the active componend is more conducive to excite holistic health product
Immunity enhancing effect.
In this process, in order to reduce the difficulty of spray drying, while improving the uniformity of particle, concentration condition preferably
For：
Vacuum (Zhen Kong Du≤0.07Mpa) is concentrated into medicinal extract relative density for 10-12 Baume degrees.
In addition, after having extracted, can as needed crush, sieve.Need to crush before extraction, cross 10 mesh sieves.
For formulation, although the present invention can be made into the formulations such as tablet, pill, paste or capsule in theory, but be due to
The main component of the present invention is oils, therefore, is advisable with soft capsule, its absorptivity and stability are higher.
By taking soft capsule as an example, immunity enhancing effect can also be improved indirectly in terms of health products absorptivity, stability
Really, for example：
Preferably, complex health care product also includes pharmaceutically acceptable emulsifying agent 15-30 parts.
When emulsifying agent adds excessive, the absorptivity of health products can be reduced on the contrary, influence health-care effect.It is tests determined, plus
Enter 15-30 parts of emulsifying agents to be advisable.
It is preferred that emulsifying agent be beeswax, its be pure natural food materials, it is safe and harmless.
The capsule shells that soft capsule of the prior art is used are generally the formula containing pigment, but pigment is in the presence of more or less
Side effect, therefore, the invention provides following capsule shells formula：By weight,
200-500 parts of gelatin,
150-300 parts of glycerine,
250-500 parts of purified water.
Compared with prior art, capsule shells of the invention formula is simpler, safe., can if considering lucifuge demand certainly
To solve by other means, for example, change the color of outer packing, so both met lucifuge needs, and turn avoid introducing pigment
Deng hypotoxicity raw material.As example, if any other side demand, then as far as possible not to edible part addition exogenous material, and
It is improved on packing.
In the formula of above-mentioned capsule shells, the content of each composition can also be improved further, to improve stability, for example：
Gelatin is preferred 400-500 parts, and glycerine is preferred 150-200 parts, and purified water is preferred 250-300 parts.
The capsule shells can use following preparation method：First glycerine, purified water are mixed, gained mixture after gelatin is added
Stirred 1-2 hours at 65-75 DEG C, then stand 2-3 hours, cast molding afterwards obtains rubber, is molded using capsule machine pelleting.
To sum up, compared with prior art, the present invention achieves following technique effect：
(1) Seabuckthorm Seed Oil, Boxthorn Seed Oil, ganoderma lucidum spore oil, five kinds of composition science of gadol extract and vitamin E are matched somebody with somebody
5, cooperate with, significantly enhance body immunity, play significant antitumaous effect；
(2) auxiliary material of science species and proportioning is introduced, the absorptivity of health products is improved, so as to improve immunity indirectly
Enhancing effect；
(3) pigment conventional in capsule shells is removed, the security and quality of health products is improved；
(4) by improving CO2The operating condition of supercritical extraction process, is improved to seabuckthorn seeds, matrimony vine seed or ganoderma lucidum spore
Oily extraction yield in son, improves active component ratio, and avoid a series of caused by the materials such as introducing organic solvent
Problem (such as removing solvent cost, blowdown flow rate, dissolvent residual)；
(5) yield of gadol extract is improved by improving the extraction process of rhodiola root, product quality is improved.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, but ability
Field technique personnel will be understood that following described embodiment is a part of embodiment of the invention, rather than whole embodiments,
The present invention is merely to illustrate, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument
Unreceipted production firm person, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
Seabuckthorm Seed Oil is extracted from seabuckthorn seeds：
1st, pre-process：Seabuckthorn seeds are cleaned, dust and other impurity is screened out.
2、CO2Supercritical extract：Temperature be 25 DEG C, pressure be to extract once under conditions of 30MPa or so, collect respectively
Oil and the dregs of fat.
3rd, degumming, depickling：Plus alkali depickling, determine to need after alkali number, plus alkali with crude oil acid value to stir 10 with 90rpm speed
Minute, heated in deacidification with 1 DEG C/min heating rates.
The component content of detection gained Seabuckthorm Seed Oil, it is as a result as follows：By weight percentage, protein is 16%, vitamin E
For 1.35%, linoleic acid be 12.3% and leukotrienes is 10%.
Embodiment 2
Seabuckthorm Seed Oil is extracted from seabuckthorn seeds：
1st, pre-process：Seabuckthorn seeds are cleaned, dust and other impurity is screened out.
2、CO2Supercritical extract：Temperature be 35 DEG C, pressure be to extract once under conditions of 20MPa, collect respectively oil and
The dregs of fat.
3rd, degumming, depickling：Plus alkali depickling, determine to need after alkali number, plus alkali with crude oil acid value to stir 10 with 90rpm speed
Minute, heated in deacidification with 1 DEG C/min heating rates.
The component content of detection gained Seabuckthorm Seed Oil, it is as a result as follows：By weight percentage, protein is 16.8%, dimension life
Plain E 2.51%, linoleic acid are 12% and leukotrienes is 10.5%.
Embodiment 3
Boxthorn Seed Oil is extracted from matrimony vine seed：
Step and condition be the same as Example 1.
The component content of detection gained Boxthorn Seed Oil, it is as a result as follows：
By weight percentage, linoleic acid 61.5%, alpha-linolenic acid 3.1%, gamma-Linolenic acid 3.0%, vitamin E
0.452% and selenium 0.44/100000.
Embodiment 4
Ganoderma lucidum spore oil is extracted from Reishi sporule：
Step and condition be the same as Example 1.
The composition of detection gained ganoderma lucidum spore oil is more containing triterpenes aliphatic acid, unrighted acid, organic germanium and ganoderma lucidum
Sugar.
Embodiment 5
Prepare gadol extract：
1st, pre-process：Dry rhodiola root rhizome is crushed, can be by 10 mesh sieves after crushing, feed intake tinning batch charging coefficient
12-13%.
2nd, first time refluxing extraction：6 times of 80% alcohol-waters measured are added into rhodiola root rhizome, and (referring to ethanol volume ratio is
80%) 90 DEG C, are heated to, and is incubated extraction 2h, middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, is received
Collect first time extract solution.
3rd, second of refluxing extraction：80% alcohol-water of 4 times of amounts is added into rhodiola root rhizome, 95 DEG C are heated to, and protect
Temperature extracts 90min, and middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, collects second of extract solution.
4th, concentrate：Merge extract solution twice, be concentrated in vacuo, Zhen Kong Du≤0.07Mpa are concentrated into medicinal extract relative density
For 10 Baume degrees.
5th, dry：Medicinal extract spray drying after concentrated, intake air temperature is 155 DEG C, outlet temperature is 95 DEG C.
As a result：The content of rhodioside in Detection and Extraction thing, up to 80wt%.
Embodiment 6
Prepare gadol extract：
1st, pre-process：Dry rhodiola root rhizome is crushed, can be by 10 mesh sieves after crushing, feed intake tinning batch charging coefficient
12-13%.
2nd, first time refluxing extraction：6 times of 90% alcohol-waters measured are added into rhodiola root rhizome, and (referring to ethanol volume ratio is
90%) 70 DEG C, are heated to, and is incubated extraction 2h, middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, is received
Collect first time extract solution.
3rd, second of refluxing extraction：90% alcohol-water of 4 times of amounts is added into rhodiola root rhizome, 70 DEG C are heated to, and protect
Temperature extracts 90min, and middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, collects second of extract solution.
4th, concentrate：Merge extract solution twice, be concentrated in vacuo, Zhen Kong Du≤0.07Mpa are concentrated into medicinal extract relative density
For 10 Baume degrees.
5th, dry：Medicinal extract spray drying after concentrated, intake air temperature is 130 DEG C, outlet temperature is 90 DEG C.
As a result：The content of rhodioside in Detection and Extraction thing, up to 67wt%.
Embodiment 7
Prepare capsule shells：
1st, feeding：Gelatin 400g, glycerine 200g, purified water 250g.
2nd, prepare：First glycerine, purified water are mixed, gained mixture after gelatin is added and is stirred 2 hours at 65 DEG C, then it is quiet
Put 2 hours, cast molding afterwards obtains rubber, be molded using capsule machine pelleting.
Embodiment 8
From embodiment 7 to differ only in formula different, be：Gelatin 500g, glycerine 150g, purified water 500g.
Embodiment 9
From embodiment 7 to differ only in formula different, be：Gelatin 400g, glycerine 200g, purified water 300g.
Embodiment 10
Prepare complex health care product：
1st, draw materials：Seabuckthorm Seed Oil (gained of embodiment 1) 400g, Boxthorn Seed Oil (gained of embodiment 3) 100g, ganoderma lucidum spore oil
(gained of embodiment 4) 50g, gadol extract (gained of embodiment 5) 50g, vitamin e1 5g, beeswax 15g.
2nd, capsule is prepared：All raw materials in 1st step are mixed, homogeneous, in the capsule shells that the offer of embodiment 9 is provided.
Embodiment 11
From embodiment 10 to differ only in beeswax consumption different, be 30g.
Embodiment 12
It is different from the proportioning for differing only in primary raw material of embodiment 10, i.e. Seabuckthorm Seed Oil, Boxthorn Seed Oil, Reishi sporule
The proportioning of oil, gadol extract and vitamin E, be：Seabuckthorm Seed Oil 500g, Boxthorn Seed Oil 50g, ganoderma lucidum spore oil 100g are red
Red-spotted stonecrop extract 20g, vitamin E2 0g, beeswax 15g.
Embodiment 13
It is different from the proportioning for differing only in primary raw material of embodiment 10, i.e. Seabuckthorm Seed Oil, Boxthorn Seed Oil, Reishi sporule
The proportioning of oil, gadol extract and vitamin E, be：Seabuckthorm Seed Oil 300g, Boxthorn Seed Oil 150g, ganoderma lucidum spore oil 30g are red
Red-spotted stonecrop extract 70g, vitamin e1 0g, beeswax 15g.
Embodiment 14
Beeswax is free of in health caring product prescription with differing only in for embodiment 10.
Comparative example 1
It is different from the proportioning for differing only in primary raw material of embodiment 10, i.e. Seabuckthorm Seed Oil, Boxthorn Seed Oil, Reishi sporule
The proportioning of oil, gadol extract and vitamin E, be：Seabuckthorm Seed Oil 510g, Boxthorn Seed Oil 45g, ganoderma lucidum spore oil 25g, red scape
Its extract 75g, vitamin E 8g.
Comparative example 2
Comparative example 2 is commercially available Seabuckthorm Seed Oil and Boxthorn Seed Oil in mass ratio 4:1 is made into, and manufacturing process is with comparative example 1.
Comparative example 3
Comparative example 3 is commercially available Boxthorn Seed Oil and commercially available ganoderma lucidum spore oil in mass ratio 8:1 is made into, the same comparative example of manufacturing process
1。
Comparative example 4
Comparative example 4 is commercially available Seabuckthorm Seed Oil and commercially available gadol extract in mass ratio 8:1 is made into, and manufacturing process is same to be compared
Example 1.
Comparative example 5
Comparative example 5 is commercially available Seabuckthorm Seed Oil, Boxthorn Seed Oil and commercially available ganoderma lucidum spore oil in mass ratio 8:2:1 is made into, and makes
Process is with comparative example 1.
Comparative example 6
Comparative example 6 is commercially available Seabuckthorm Seed Oil, Boxthorn Seed Oil and commercially available gadol extract in mass ratio 8:2:1 is made into, system
Make process with comparative example 1.
Comparative example 7
Comparative example 7 is commercially available Seabuckthorm Seed Oil, Boxthorn Seed Oil and vitamin E in mass ratio 80:20:3 are made into, and manufacturing process is same
Comparative example 1.
Comparative example 8
Comparative example 8 is commercially available Seabuckthorm Seed Oil, ganoderma lucidum spore oil and gadol extract in mass ratio 8:1:1 is made into, and makes
Process is with comparative example 1.
Comparative example 9
Different from the source for differing only in gadol extract of embodiment 10, it uses patent application
Embodiment 1 (rhodiola root rhizome is only added during extraction) in CN101491568A.
The global natural perfume material Co., Ltd in commercially available Seabuckthorm Seed Oil producer Jiangxi used in the comparative example of the present invention, it is commercially available
Boxthorn Seed Oil producer prays for blessings in Ningxia medlar biological Science and Technology Ltd., and commercially available ganoderma lucidum spore oil producer Guangzhou Jingjing biotechnology has
Limit company, Xi'an Yuan Sen bio tech ltd of commercially available gadol extract producer.
Influence of the experimental example health products to immune function of mice
1st, the present invention promotes helper T lymphocyte (Th cells) propagation
Experimental animal：Healthy female or male mice, 18~22g of body weight, 4 week old.
A. experimental animal continuous gavage is administered 10 days, dosage such as table 1 below：
Table 1
B. the 11st day, after sterile separating mouse spleen cell, 70%Percoll density gradient centrifugations is used, single core is obtained
Cell suspension；
C. anti-CD4+T fluorescent labeled antibodies are added, single CD4+T cells are obtained by selected by flow cytometry apoptosis；
D.96 hole cel culture plates, 5 × 106/ mL is inoculated with；
E. after incubator culture 48h, WST methods detection cell proliferative conditions.
The different health products of the present invention are stimulated into CD4+T lymphocyte 48h, its stimulation situation is detected.Experimental result is shown：
Compared with negative control group and positive controls, senior middle school's low dosages of various embodiments of the present invention (20mg/kg, 40mg/kg and
60mg/kg) mouse spleen mononuclearcell can be promoted to breed and there is statistical significance, increase rate is more than 7.5% (with life
Manage the contrast of salt solution group).And comparing embodiment 10 to 13 can be found with embodiment 14, immune work(is significantly improved after addition beeswax
Energy.Compare it is of the invention can be found with comparative example 1, in formula species under the same conditions, if the proportioning of composition is different, reached
Health-care efficacy difference it is larger.Each health products are as shown in table 2 to the proliferation rate of T cell under middle dosage compared to physiological saline.
Table 2
| Group | Appreciation rate/g |
| Embodiment 10 | 10.5% |
| Embodiment 11 | 9.8% |
| Embodiment 12 | 8.7% |
| Embodiment 13 | 8.9% |
| Embodiment 14 | 7.5% |
| Comparative example 1 | 4.9% |
| Comparative example 2 | 2.1% |
| Comparative example 3 | 2.5% |
| Comparative example 4 | 2.4% |
| Comparative example 5 | 3.1% |
| Comparative example 6 | 2.7% |
| Comparative example 7 | 2.8% |
| Comparative example 8 | 3.2% |
| Comparative example 9 | 3.5% |
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of complex health care product of strengthen immunity, it is characterised in that be mainly made up of following component：By weight,
2. complex health care product according to claim 1, it is characterised in that by weight,
3. complex health care product according to claim 1, it is characterised in that the Seabuckthorm Seed Oil includes following component：By weight
Percentage composition meter is measured,
Protein >=16%, vitamin E 1.35%-2.51%, linoleic acid >=12% and leukotrienes >=10%；
Preferably, the Seabuckthorm Seed Oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, the overcritical extraction
It is 20-40MPa for 25-35 DEG C, pressure to follow the example of the temperature used.
4. complex health care product according to claim 1, it is characterised in that the Boxthorn Seed Oil includes following component：By weight
Percentage composition meter is measured,
Linoleic acid >=61.5%, alpha-linolenic acid >=3.1%, gamma-Linolenic acid >=3.0%, vitamin E >=0.452% and selenium >=
0.44/100000；
Preferably, the Boxthorn Seed Oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, the overcritical extraction
It is 20-40MPa for 25-35 DEG C, pressure to follow the example of the temperature used.
5. complex health care product according to claim 1, it is characterised in that the ganoderma lucidum spore oil includes following component：Three
Terpene aliphatic acid, unrighted acid, organic germanium and GL-B；
Preferably, the ganoderma lucidum spore oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described overcritical
The temperature that extraction is used is 20-40MPa for 25-35 DEG C, pressure.
6. complex health care product according to claim 1, it is characterised in that the gadol extract uses following methods system
：
Multiple to the backflow extraction of rhodiola root rhizome using 80-85% ethanol as solvent, temperature during backflow extraction is 80-90 every time
DEG C, solid-to-liquid ratio be 1:4-6；Concentrate afterwards, then in the condition that intake air temperature is 150-155 DEG C, outlet temperature is 90-95 DEG C
Lower spray drying.
7. complex health care product according to claim 1, it is characterised in that the formulation of the complex health care product is soft capsule
Agent.
8. complex health care product according to claim 7, it is characterised in that also contain emulsifying agent in the soft capsule, described
The consumption of emulsifying agent is preferably 15-30 parts；
Preferably, the emulsifying agent is beeswax.
9. complex health care product according to claim 7, it is characterised in that soft capsule shell master used in the soft capsule
To be made up of following component：By weight,
200-500 parts of gelatin, preferably 400-500 parts,
150-300 parts of glycerine, preferably 150-200 parts,
250-500 parts, preferably 250-300 parts of purified water.
10. complex health care product according to claim 9, it is characterised in that the preparation method of the soft capsule shell is：First will
Glycerine, purified water mixing, add gained mixture after gelatin and are stirred 1-2 hours at 65-75 DEG C, then stand 2-3 hours, afterwards
Cast molding obtains rubber, is molded using capsule machine pelleting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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