CN107156846A - Complex health care product that is a kind of antifatigue and improving anoxia endurance - Google Patents
Complex health care product that is a kind of antifatigue and improving anoxia endurance Download PDFInfo
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- CN107156846A CN107156846A CN201710480278.7A CN201710480278A CN107156846A CN 107156846 A CN107156846 A CN 107156846A CN 201710480278 A CN201710480278 A CN 201710480278A CN 107156846 A CN107156846 A CN 107156846A
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- seed oil
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a kind of antifatigue and raising anoxia endurance complex health care product.Complex health care product is mainly made up of following component：By weight, 200 400 parts of camellia seed oil, 100 200 parts of Boxthorn Seed Oil, 50 150 parts of gadol extract, 0 20 parts of vitamin e1.The emphasis of each component of the invention is different; but pass through the coordinated of various materials; start with from multiple dimensions such as blood, blood vessel, the object removed, protection immunocyte, activating immune system, elimination superoxide radical, the oxygen-enriched abilities of offer; the undesirable element in the blood circulation system and immune system of human body is eliminated comprehensively; lift blood circulation system and the physiological function of immune system; and good operating condition is at, drastically increase the antifatigue effect of human body and improve anoxia endurance；Present invention materials are natural simultaneously, have no toxic side effect.
Description
Technical field
The present invention relates to health product technology field, protected more particularly, to a kind of antifatigue and raising anoxia endurance compound
Strong product.
Background technology
Fatigue refers to that organism physiology process can not continue on the specified level of its function or predetermined motion can not be maintained strong
Degree.The mechanism occurred on fatigue, Edward are it is proposed that " catastrophe theory ", it thinks that overall fatigue is fixed by a certain kind
Or caused by several reasons, it is excitability, the energy supply of muscle before the product of a variety of cause fatigue factor summations, sports fatigue
Level, power output are in a process being gradually reduced.When the summation effect of various cause fatigue factors reaches certain critical value
When, a unexpected decline just occurs, shows as that excitability is collapsed suddenly, energy supply is blocked suddenly, muscle strength or defeated
Go out power suddenly to decline, then occur in that fatigue.
Fatigue is a comprehensive physiology course for being related to many Physiology and biochemistry factors, and the reason for causing fatigue has very
Many, including in terms of working environment, eating habit and life habit, particularly disease causes the stress of patient, muscle power to disappear
Consumption, the resistance of body each function weaken and consumption of the medicine to muscle power, easily produce sense of fatigue.Fatigue is that body is mental
A kind of normal physiological phenomenon necessarily occurred when activity or physical exertion are to certain phase, had both indicated the original work energy of body
The temporary transient decline of power, is likely to be the tendency that body develops into sick and wounded state again.After 1980s, knowledge is quick-fried
Fried, rhythm of life is constantly accelerated, and the competition for being full of life each stage is also increasingly fierce.But, the physiological function of the mankind does not have
Therefore there is corresponding evolution.The operating of such excess load, great harm has been carried out to mankind's health care belt.According to expert statistics, entirely
Ball population about more than 35% is in fatigue state.
The harm of fatigue is a lot of, and it causes the function of each system of body to be in a relatively low level, and body resistance is external
The ability reduction of pathogen, the reduction of NK, people is just easily sick.The reduction meeting of human natural killer cell simultaneously
Greatly increase the probability of happening of the high-risk illness such as cardiovascular and cerebrovascular disease, diabetes, cancer.When human body is in fatigue state,
Due to the murder by poisoning to cardiac muscle cell of reduction and physiological fatigue of cardiac muscle cell's energy, myocardial contractive power diminishes, the pump blood work(of heart
It can reduce, among blood vessel microcirculation disorder occurs for sludging, and VPV slows down, and blood rubbish increase, and triggers the various hearts
Cranial vascular disease.In addition, excessive fatigue will be such that the aging of body produces " aging acceleration ".After people's middle age, normally
Body aging speed be annual 1%~5%, once with physiological fatigue, the aging rate of body can be continuously increased, and aging adds
The direct result of speed is exactly that the aging course for needing 50 years originally may be completed just for 15 years.
At present, tumour is the first cause for causing in developed country people dead, is to cause people in developing country
The second dead reason.Fatigue is one of most common malaise symptoms of tumor patient experience.US National integrates cancer net
Cancer Related Fatigue (Cancer related Fatigue, the CRF) clinical practice guideline (2012.1 editions) that network is announced is by CRF
Be defined as, be it is a kind of it is related to tumour or oncotherapy, with Recent Activity it is disproportionate and influence daily life one kind make us
Continue discomfort, subjective tired urgency or tired out sense tired out in terms of body, emotion and/or cognition.CRF can be drawn in itself by tumour
Rise or the diagnosis and treatment process (such as receive chemotherapy, radiotherapy, bone-marrow transplantation, or application BRM etc.) of tumour in go out
Existing, it is also the predictive factor of the quality and satisfaction of an important and independent life of tumor patient.CRF is still lasting
Underestimated, and usually do not obtained medical treatment.
In addition, chronic fatigue syndrome (Chronic Fatigue Syndrome, abbreviation CFS) in fatigue symptom also day
Benefit receives the concern of people, and CFS is one group tired for outstanding behaviours to continue for a long time, while with low-heat, headache, throat
Bitterly, one group based on the performance of the non-specificity such as muscle arthralgia, absent minded, decrease of memory, sleep-disorder and depression
Syndrome, physical examination and the general Non Apparent Abnormality of routine inspection.CFS is apt to occur in 20~50 years old age group, common with women.
Work and life of the CFS to patient cause more serious influence, are increasingly subject to the highest attention of medical field.
The method of fatigue-relieving carries out body adjustment by sleep, recuperation mostly, on the other hand by the tune of external material
Reason improves physical function.But current market is made a general survey of, is used for antifatigue health products still without a effect highly significant.
In view of this, it is special to propose the present invention.
The content of the invention
It is an object of the invention to provide a kind of antifatigue and raising anoxia endurance complex health care product, the compound is protected
Strong product utilize the compatibility relationship of science, and four main component collaborations play effect that is more significant antifatigue and improving anoxia endurance
Really, and draw materials natural, have no toxic side effect.
In order to realize the above object the invention provides following technical scheme：
Complex health care product that is a kind of antifatigue and improving anoxia endurance, is mainly made up of following component：By weight,
Wherein, the content of the monounsaturated fatty acids in camellia seed oil is highest in all edible oil.It is rich in Ω -3
Aliphatic acid, to prevention and treatment heart disease, cardiovascular and cerebrovascular diseases, diabetes have good effect.The specific life that camellia seed oil contains
Reason active material Tea Polyphenols and camellianin have obvious effect to reduction cholesterol and anticancer.Its physiologically active ingredient angle contained
MF59 has a good oxygen-enriched ability, thus can anti anoxia and antifatigue, and with improving body immunity and promote stomach and intestine
The function in road.Camellia seed oil can also uvioresistant, prevent sunburn and reduce wrinkle, it is very effective to chloasma, sunburn.Camellia seed
Oil can effectively reduce blood fat, steady decompression, because performance is cooler, there is cool blood, effect of hemostasis is lost and easily got ecited for irascibility
Hyperpietic's curative effect it is further preferred that.
Boxthorn Seed Oil contains abundant and comprehensive bioactive substance and the sub- oil of oleic acid, linoleic acid, a-leukotrienes, γ
Acid, selenium, trace element, bioactive substance, EGF, bata-carotene, SOD etc..Boxthorn Seed Oil is to regulation blood fat, guarantor
Liver improving eyesight, kidney tonifying anticancer have obvious effect.
Gadol extract mainly lipid containing phenylpropyl alcohol and flavonoid class, Main Ingredients and Appearance are rhodioside and Jujubogenin tyrosol, network
Sai Wei, its unique active chemical components by the direct specific stimulation defendd human immunity, search for and destroy body by
Infection cell.Gadol extract can also improve the human body state of mind, the melancholy sense of reduction.Gadol extract can improve muscle fat
Hemochrome and red blood cell level in fat ratio and lifting blood, improve sexual function of human body, strengthen memory.Gadol extract has suitable
It should act on as former state and dual regulation.Bidirectional modulation nervous centralis, anti anoxia radiation proof restoration and protection body.
Vitamin E is that life continues one of required nutrient.It can promote sex hormone to secrete, and improve fecundity, protect
T lymphocytes, protection red blood cell, Green Tea Extract oxidation are protected, the lipid peroxidation reaction in ocular lens body can be suppressed, make peripheral blood
Enlargement of pipe, improves blood circulation.
In the present invention, there is stronger adjustment blood fat and oxygen-enriched ability, Boxthorn Seed Oil is except energy in camellia seed oil
Enough remove the rubbish in blood, moreover it is possible to reduce vascular wall cholesterol deposition, prevent from containing in blood fat atherosclerosis, Boxthorn Seed Oil
Some SOD, cooperate together with vitamin E, the effect with very strong elimination superoxide radical, the red scape in gadol extract
Its glycosides and Jujubogenin tyrosol, network plug dimension, mainly by direct stimulating immune system, immune cell activated, to strengthen human immunity system
The immunologic function of system, it is seen then that in the Halth-care composition that the present invention is provided, the emphasis of each component is different, but by each
The coordinated of material is planted, from blood, blood vessel, the object removed, protection immunocyte, activating immune system, elimination super oxygen certainly
Started with by multiple dimensions such as base, the oxygen-enriched abilities of offer, eliminated comprehensively in the blood circulation system and immune system of human body not
The physiological function of good factor, lifting blood circulation system and immune system, and good operating condition is at, greatly
Improve the antifatigue effect of human body and improve anoxia endurance.
In addition, not introducing the medicinal material or auxiliary material of any toxic side effect in the formula of the present invention, therefore it is used for a long time more
Safety.
Formula can also further optimize above, to obtain more preferable immunity enhancing effect, and for example formula is：
Oily composition has a major impact to the health-care effect of formula in all formulas described above, in order to improve health care effect
The oil of fruit preferably following quality：
Preferably, the camellia seed oil contains unrighted acid, camellin, Tea Polyphenols, squalene, protein, dimension life
Plain A, vitamin B, vitamin D and vitamin E；Wherein, weight percentage, unrighted acid accounting >=90%, institute
Stating unrighted acid includes oleic acid and linoleic acid, and oleic acid accounting is >=83%, linoleic acid accounting >=13%.
The oleic acid accounting refers to the proportion that oleic acid accounts for camellia seed oil, and the linoleic acid accounting refers to linoleic acid and accounts for camellia seed oil
Proportion.
The camellia seed oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super to face
The temperature that boundary's extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, camellia seed is after ultramicro grinding, and the particle diameter of camellia powder of seeds is less than 100 μm, and powder diameter is uniform, carefully
Cell wall is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2The temperature that supercritical extraction is used
For normal temperature, camellia seed is in CO2Atmosphere in, should under the conditions of can ensure that the active component in camellia seed is particularly temperature sensitive
Active material and oxidizable active material do not degraded by high-temperature oxygen, and the recovery rate of active component is high, obtains
Camellia seed oil quality better.
Preferably, the Boxthorn Seed Oil includes following component：Weight percentage, linoleic acid >=61.5%, α-Asia
Numb acid >=3.1%, gamma-Linolenic acid >=3.0%, vitamin E >=0.452% and selenium >=0.44/100000.
The Boxthorn Seed Oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super to face
The temperature that boundary's extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, matrimony vine seed is after ultramicro grinding, and the particle diameter at matrimony vine seed powder end is less than 100 μm, and powder diameter is uniform, carefully
Cell wall is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2The temperature that supercritical extraction is used
For normal temperature, matrimony vine seed is in CO2Atmosphere in, should under the conditions of can ensure that the active component in matrimony vine seed is particularly temperature sensitive
Active material and oxidizable active material do not degraded by high-temperature oxygen, and the recovery rate of active component is high, obtains
Boxthorn Seed Oil quality better.
There is low recovery rate, dissolvent residual, active component in squeezing, the organic solvent extraction of routine, and
CO of the present invention2Supercritical extraction process completely avoid problem above.
Wherein, degumming, depickling for example can add alkali depickling (to be determined with crude oil acid value after alkali number, plus alkali using conventional means
Need to stir 10 minutes with 90rpm speed), heating is needed in deacidification, and heating rate preferably is 1 DEG C/min.
Gadol extract used above can also use conventional extracting method, but preferably following extraction process：
Multiple to the backflow extraction of rhodiola root rhizome using 80-85% ethanol as solvent, temperature during backflow extraction is every time
80-90 DEG C, solid-to-liquid ratio be 1:4-6 (weight ratio)；Concentrate afterwards, then intake air temperature be 150-155 DEG C, outlet temperature be
It is spray-dried under conditions of 90-95 DEG C.
The gadol extract purity that this technique is extracted is high, and obtained Proportion of the active componend is more conducive to excite holistic health product
It is antifatigue and improve anoxia endurance effect.
In this process, in order to reduce the difficulty of spray drying, while improving the uniformity of particle, concentration condition preferably
For：
Vacuum (Zhen Kong Du≤0.07Mpa) is concentrated into medicinal extract relative density for 10-12 Baume degrees.
In addition, after having extracted, can as needed crush, sieve.
For formulation, although the present invention can be made into the formulations such as tablet, pill, paste or capsule in theory, but be due to
The main component of the present invention is oils, therefore, is advisable with soft capsule, its absorptivity and stability are higher.
By taking soft capsule as an example, it can also improve antifatigue and carry indirectly in terms of health products absorptivity, stability
High anoxia endurance effect, for example：
Preferably, complex health care product also includes pharmaceutically acceptable emulsifying agent 15-30 parts.
When emulsifying agent adds excessive, the absorptivity of health products can be reduced on the contrary, influence health-care effect.It is tests determined, plus
Enter 15-30 parts of emulsifying agents to be advisable.
It is preferred that emulsifying agent be beeswax, its be pure natural food materials, it is safe and harmless.
The capsule shells that soft capsule of the prior art is used are generally the formula containing pigment, but pigment is in the presence of more or less
Side effect, therefore, the invention provides following capsule shells formula：By weight,
Compared with prior art, capsule shells of the invention formula is simpler, safe., can if considering lucifuge demand certainly
To solve by other means, for example, change the color of outer packing, so both met lucifuge needs, and turn avoid introducing pigment
Deng hypotoxicity raw material.As example, if any other side demand, then as far as possible not to edible part addition exogenous material, and
It is improved on packing.
In the formula of above-mentioned capsule shells, the content of each composition can also be improved further, to improve stability, for example：
Gelatin is preferred 400-500 parts, and glycerine is preferred 150-200 parts, and purified water is preferred 400-500 parts.
The capsule shells can use following preparation method：First glycerine, purified water are mixed, gained mixture after gelatin is added
Stirred 1-2 hours at 65-75 DEG C, then stand 2-3 hours, cast molding afterwards obtains rubber, is molded using capsule machine pelleting.
To sum up, compared with prior art, the present invention achieves following technique effect：
(1) by camellia seed oil, Boxthorn Seed Oil, four kinds of composition scientific compatibilities of gadol extract and vitamin E, collaboration is played
Effect, significantly enhances antifatigue and anoxia endurance effect：
The emphasis of each component is different, but by the coordinated of various materials, from blood, blood vessel, pair removed
As, protection immunocyte, activating immune system, eliminate superoxide radical, multiple dimensions such as oxygen-enriched ability are provided started with, disappear comprehensively
Except the undesirable element in the blood circulation system and immune system of human body, the life of lifting blood circulation system and immune system
Function is managed, and is at good operating condition, the antifatigue effect of human body is drastically increased and improves hypoxic tolerance
Power.
(2) auxiliary material of science species and proportioning is introduced, the absorptivity of health products is improved, so as to improve indirectly antifatigue
With anoxia endurance effect.
(3) pigment conventional in capsule shells is removed, the security of health products is improved.
(4) by improving CO2The operating condition of supercritical extraction process, not only improves the ratio of main active component in oil
Example, and avoid introduce caused by the material such as organic solvent a series of problems (for example remove solvent cost, it is blowdown flow rate, molten
Agent residual etc.).
(5) yield of extract is improved by improving the extraction process of rhodiola root, while improving main in extract
The ratio of active component.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, but ability
Field technique personnel will be understood that following described embodiment is a part of embodiment of the invention, rather than whole embodiments,
The present invention is merely to illustrate, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument
Unreceipted production firm person, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
Camellia seed oil is extracted from camellia seed：
1st, pre-process：Camellia seed is cleaned, dust and other impurity is screened out, is put into afterwards in micronizer and carries out powder
Broken, the particle diameter after crushing is less than 100 microns.
2、CO2Supercritical extract：Temperature be 25 DEG C, pressure be to extract once under conditions of 30MPa or so, collect respectively
Oil and the dregs of fat.
3rd, degumming, depickling：Plus alkali depickling, determine to need after alkali number, plus alkali with crude oil acid value to stir 10 with 90rpm speed
Minute, heated in deacidification with 1 DEG C/min heating rates.
The component content of detection gained camellia seed oil, it is as a result as follows：By weight percentage,
Unrighted acid accounting is 90%, and oleic acid accounting is 83%, and linoleic acid accounting is 13%, and vitamin A, dimension
Raw element B, vitamin D and vitamin E.
Embodiment 2
Camellia seed oil is extracted from camellia seed：
1st, pre-process：Camellia seed is cleaned, dust and other impurity is screened out, is put into afterwards in micronizer and carries out powder
Broken, the particle diameter after crushing is less than 100 microns.
2、CO2Supercritical extract：Be in temperature, 35 DEG C, pressure be 20MPa under conditions of extract once, respectively collect oil
And the dregs of fat.
3rd, degumming, depickling：Plus alkali depickling, determine to need after alkali number, plus alkali with crude oil acid value to stir 10 with 90rpm speed
Minute, heated in deacidification with 1 DEG C/min heating rates.
Embodiment 3
Boxthorn Seed Oil is extracted from matrimony vine seed：
Step and condition be the same as Example 1.
The component content of detection gained Boxthorn Seed Oil, it is as a result as follows：
By weight percentage, linoleic acid 61.5%, alpha-linolenic acid 3.1%, gamma-Linolenic acid 3.0%, vitamin E
0.452% and selenium 0.44/100000.
Embodiment 4
Prepare gadol extract：
1st, pre-process：Dry rhodiola root rhizome is crushed, can be by 10 mesh sieves after crushing, feed intake tinning batch charging coefficient
12-13%.
2nd, first time refluxing extraction：6 times of 80% ethanol measured are added into rhodiola root rhizome, and (referring to ethanol volume ratio is
80%) 90 DEG C, are heated to, and is incubated extraction 2h, middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, is received
Collect first time extract solution.
3rd, second of refluxing extraction：80% ethanol of 4 times of amounts is added into rhodiola root rhizome, 95 DEG C are heated to, and be incubated
90min is extracted, middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, collects second of extract solution.
4th, concentrate：Merge extract solution twice, be concentrated in vacuo, Zhen Kong Du≤0.07Mpa are concentrated into medicinal extract relative density
For 10 Baume degrees.
5th, dry：Medicinal extract spray drying after concentrated, intake air temperature is 155 DEG C, outlet temperature is 95 DEG C.
Embodiment 5
Prepare gadol extract：
1st, pre-process：Dry rhodiola root rhizome is crushed, can be by 10 mesh sieves after crushing, feed intake tinning batch charging coefficient
12-13%.
2nd, first time refluxing extraction：6 times of 90% ethanol measured are added into rhodiola root rhizome, and (referring to ethanol volume ratio is
90%) 70 DEG C, are heated to, and is incubated extraction 2h, middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, is received
Collect first time extract solution.
3rd, second of refluxing extraction：90% ethanol of 4 times of amounts is added into rhodiola root rhizome, 70 DEG C are heated to, and be incubated
90min is extracted, middle intermittent cyclic is multiple, each 15min.Extraction is finished, tapping filtering, collects second of extract solution.
4th, concentrate：Merge extract solution twice, be concentrated in vacuo, Zhen Kong Du≤0.07Mpa are concentrated into medicinal extract relative density
For 10 Baume degrees.
5th, dry：Medicinal extract spray drying after concentrated, intake air temperature is 130 DEG C, outlet temperature is 90 DEG C.
Embodiment 6
Prepare capsule shells：
1st, feeding：Gelatin 400g, glycerine 200g, purified water 250g.
2nd, prepare：First glycerine, purified water are mixed, gained mixture after gelatin is added and is stirred 2 hours at 65 DEG C, then it is quiet
Put 2 hours, cast molding afterwards obtains rubber, be molded using capsule machine pelleting.
Embodiment 7
From embodiment 6 to differ only in formula different, be：Gelatin 500g, glycerine 150g, purified water 500g.
Embodiment 8
From embodiment 6 to differ only in formula different, be：Gelatin 400g, glycerine 200g, purified water 300g.
Embodiment 9
Prepare complex health care product：
1st, draw materials：Camellia seed oil (embodiment 1 is provided) 300g, Boxthorn Seed Oil (embodiment 3 is provided) 150g, rhodiola root are extracted
Thing (embodiment 4 is provided) 120g, vitamin e1 5g, beeswax 15g.
2nd, capsule is prepared：All raw materials in 1st step are mixed, homogeneous, in the capsule shells that the offer of embodiment 8 is provided.
Embodiment 10
From embodiment 9 to differ only in beeswax consumption different, be 30g.
Embodiment 11
Different from the proportioning for differing only in primary raw material of embodiment 9, i.e., camellia seed oil, Boxthorn Seed Oil, rhodiola root are carried
The proportioning of thing and vitamin E is taken, is：Camellia seed oil 400g, Boxthorn Seed Oil 100g, gadol extract 150g, vitamin e1 0g,
Beeswax 20g.
Embodiment 12
Different from the proportioning for differing only in primary raw material of embodiment 9, i.e., camellia seed oil, Boxthorn Seed Oil, rhodiola root are carried
The proportioning of thing and vitamin E is taken, is：Camellia seed oil 200g, Boxthorn Seed Oil 200g, gadol extract 50g, vitamin E2 0g,
Beeswax 15g.
Embodiment 13
With differing only in without beeswax for embodiment 9.
Comparative example 1
Different from the proportioning for differing only in primary raw material of embodiment 9, i.e., proportioning is：Camellia seed oil 420g, matrimony vine
Seed oil 90g, gadol extract 160g, vitamin e1 5g, beeswax 15g.
Comparative example 2
Comparative example 2 is commercially available camellia seed oil and Boxthorn Seed Oil in mass ratio 2:1 is made into, and manufacturing process is with comparative example 1.
Comparative example 3
Comparative example 3 is commercially available Boxthorn Seed Oil and commercially available gadol extract in mass ratio 5:4 are made into, and manufacturing process is same to be compared
Example 1.
Comparative example 4
Comparative example 4 is commercially available camellia seed oil and commercially available gadol extract in mass ratio 5:2 are made into, and manufacturing process is same to be compared
Example 1.
Comparative example 5
Comparative example 5 is commercially available camellia seed oil, Boxthorn Seed Oil and commercially available gadol extract in mass ratio 10:5:4 are made into, system
Make process with comparative example 1.
Comparative example 6
Comparative example 6 is commercially available Boxthorn Seed Oil, gadol extract and vitamin E in mass ratio 10:8:1 is made into, and makes
Journey is with comparative example 1.
Comparative example 7
The difference of comparative example 7 and embodiment 9 is only waiting the peanut oil weighed with camellia seed oil is replaced with.
Comparative example 8
Different from the source for differing only in gadol extract of embodiment 9, it uses patent application
Embodiment 1 (rhodiola root rhizome is only added during extraction) in CN101491568A.
Guangdong Bao Hua agricultural science and technologys limited company of commercially available camellia seed oil producer used in the comparative example of the present invention,
Commercially available Boxthorn Seed Oil producer prays for blessings in Ningxia medlar biological Science and Technology Ltd., the gloomy biology in commercially available gadol extract producer Xi'an source
Science and Technology Ltd..
Experimental example
1st, antifatigue effect
Animal packet：Carry out swimming power respectively to two batches mouse and exhaust experiment and biochemical indicator test.Every batch of mouse is random again
It is divided into 12 groups, every group 10.Every group of gavage 7 days.
The each group mice burden swimming power of table 1 exhausts the measurement result of time
Note：Compared with blank control group, * P ＜ 0.05, * * P ＜ 0.01.
Negative G swimming test：After each gavage 30min, the sheet lead for 5% body weight of being born a heavy burden in mouse tail root is placed in 30 DEG C
Swimming trunk in, record mouse starts swimming and all enters the time that water can not emerge more than eight seconds to head to exhaust trip for its power
The swimming time.
The each group mice serum urea nitrogen of table 2 and lactic acid dehydrogenase content (n=10)
Note：Compared with blank control group, * P ＜ 0.05, * * P ＜ 0.01.
Compared with blank control group, present invention group hepatic glycogen, muscle glycogen content rise are obvious, and middle dose group has conspicuousness poor
Different (P<0.05), high dose group has pole significant difference (P<0.01).Illustrate that target sample has obvious antifatigue effect.
2nd, anoxia endurance is tested
With the small single sex of inbred strais adult, 18-22g, every group 10, experiment sets a dosage group (1.56g/kg) and one
Individual saline control group.Given the test agent gives the time 30 days.
Each dosage group orally continuously gives various concentrations given the test agent, and control group gives equivalent capability physiological saline, in every
1 hour after secondary gavage, each group mouse is respectively put into the 250mL port grinding bottles for filling 5g soda limes (1 every bottle), vaseline is used
Bottleneck is sealed, covers tightly, is allowed to air tight, immediately timing, is stopped with breathing as index, the observation mouse time dead because of anoxic,
As a result such as table 3.
Table 3
Note：Compared with control group, * P ＜ 0.05, * * P ＜ 0.01.
As a result show, embodiment 9 is compared with control group, prolonged survival period, and with statistical significance, illustrate the present invention
Health products can significantly improve anoxia endurance, and addition beeswax health products effect better than un-added.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. complex health care product that is a kind of antifatigue and improving anoxia endurance, it is characterised in that be mainly made up of following component：Press
Weight meter,
2. complex health care product according to claim 1, it is characterised in that by weight,
3. complex health care product according to claim 1, it is characterised in that the camellia seed oil contain unrighted acid,
Camellin, Tea Polyphenols, squalene, protein, vitamin A, vitamin B, vitamin D and vitamin E；Wherein, percentage by weight
Content meter, unrighted acid accounting >=90%, the unrighted acid include oleic acid and linoleic acid, oleic acid accounting >=
83%, linoleic acid accounting >=13%；
Preferably, the camellia seed oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, the overcritical extraction
It is 20-40MPa for 25-35 DEG C, pressure to follow the example of the temperature used.
4. complex health care product according to claim 1, it is characterised in that the Boxthorn Seed Oil includes following component：By weight
Percentage composition meter is measured,
Linoleic acid >=61.5%, alpha-linolenic acid >=3.1%, gamma-Linolenic acid >=3.0%, vitamin E >=0.452% and selenium >=
0.44/100000；
Preferably, the Boxthorn Seed Oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, the overcritical extraction
It is 20-40MPa for 25-35 DEG C, pressure to follow the example of the temperature used.
5. complex health care product according to claim 1, it is characterised in that the gadol extract uses following methods system
：
Multiple to the backflow extraction of rhodiola root rhizome using 80-85% ethanol as solvent, temperature during backflow extraction is 80-90 every time
DEG C, solid-to-liquid ratio be 1:4-6；Concentrate afterwards, then in the condition that intake air temperature is 150-155 DEG C, outlet temperature is 90-95 DEG C
Lower spray drying.
6. complex health care product according to claim 1, it is characterised in that the formulation of the complex health care product is soft capsule
Agent.
7. complex health care product according to claim 6, it is characterised in that also contain emulsifying agent in the soft capsule, described
The consumption of emulsifying agent is preferably 15-30 parts.
8. complex health care product according to claim 7, it is characterised in that the emulsifying agent is beeswax.
9. complex health care product according to claim 6, it is characterised in that soft capsule shell master used in the soft capsule
To be made up of following component：By weight,
200-500 parts of gelatin, preferably 400-500 parts,
150-300 parts of glycerine, preferably 150-200 parts,
250-500 parts, preferably 400-500 parts of purified water.
10. complex health care product according to claim 9, it is characterised in that the preparation method of the soft capsule shell is：First will
Glycerine, purified water mixing, add gained mixture after gelatin and are stirred 1-2 hours at 65-75 DEG C, then stand 2-3 hours, afterwards
Cast molding obtains rubber, is molded using capsule machine pelleting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710480278.7A CN107156846A (en) | 2017-06-22 | 2017-06-22 | Complex health care product that is a kind of antifatigue and improving anoxia endurance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710480278.7A CN107156846A (en) | 2017-06-22 | 2017-06-22 | Complex health care product that is a kind of antifatigue and improving anoxia endurance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107156846A true CN107156846A (en) | 2017-09-15 |
Family
ID=59819976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710480278.7A Pending CN107156846A (en) | 2017-06-22 | 2017-06-22 | Complex health care product that is a kind of antifatigue and improving anoxia endurance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107156846A (en) |
Cited By (1)
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| CN107595997A (en) * | 2017-10-10 | 2018-01-19 | 上海宣泰生物科技有限公司 | Alimentation composition and its application containing pufa oils |
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Application publication date: 20170915 |