CN101961378A - Formula of health-care product for resisting oxidation and enhancing immunity - Google Patents

Formula of health-care product for resisting oxidation and enhancing immunity Download PDF

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Publication number
CN101961378A
CN101961378A CN2010102143622A CN201010214362A CN101961378A CN 101961378 A CN101961378 A CN 101961378A CN 2010102143622 A CN2010102143622 A CN 2010102143622A CN 201010214362 A CN201010214362 A CN 201010214362A CN 101961378 A CN101961378 A CN 101961378A
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China
Prior art keywords
grams
seed
formula
enhancing immunity
hippophae
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Pending
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CN2010102143622A
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Chinese (zh)
Inventor
邹元生
徐瑞
温中平
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HIGHLAND SHENGGUO SEA-BUCKTHORN PRODUCT Co Ltd
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HIGHLAND SHENGGUO SEA-BUCKTHORN PRODUCT Co Ltd
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Priority to CN2010102143622A priority Critical patent/CN101961378A/en
Publication of CN101961378A publication Critical patent/CN101961378A/en
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Abstract

The invention discloses a soft capsule health-care product for resisting oxidation and enhancing immunity. The product is researched and prepared for aged and elderly people, people of low immunity and radiation damage suffers. Seabuckthorn seed proanthocyanidin extract, seabuckthorn seed oil or seabuckthorn berry oil and perilla herb oil into first formula and second formula, and soft capsules are prepared according to the first formula and second formula; and the product has an obvious function of resisting oxidation and enhancing immunity. The product is used for the aged and elderly people, the people of low immunity and the radiation damage suffers for replenishing anti-oxidation nutriment extracted from a medicinal and edible variety, so that the anti-oxidation function is improved and the immunity is enhanced, and various diseases are prevented from occurring and worsening. As proved by animal tests and human test-meals, the seabuckthorn seed proanthocyanidin soft capsules prepared in the invention have the obvious health-care function of resisting oxidation and enhancing immunity.

Description

The health caring product prescription of a kind of antioxidation and enhancing immunity
Technical field:
The present invention relates to human body antioxidation and enhancing immunity function, for it develops seed of Fructus Hippophae proanthocyanidin soft capsule specially.
Background technology:
1. middle-aged and elderly people increased with the age, the activity of human body antioxidase descends, immunologic function also descends gradually, show that the superoxide dismutase (SOD) in the blood, the activity of glutathion peroxidase (GSH-px) reduce, too much oxygen-derived free radicals can not be removed timely, lipid peroxide in the blood (LPO) obviously increases, and resistivity descends.Environmental factorss such as atmospheric pollution simultaneously,, food pollution, radiation pollution also can cause the body free radical to generate too much undoubtedly.Medical research shows, the body free radical generates too much, or remove the free radical ability and weaken, the chain reaction that oxygen-derived free radicals causes causes macromole damage in the bodies such as lipid, DNA cell membrane behind internal metabolism, make immune function depression and impel generation, the development of multiple disease, comprise heart disease, atherosclerosis, cancer and alzheimer disease etc.For this reason, middle-aged and elderly people, immunocompromised person, radiation damage danger person must constantly replenish safe, an amount of exogenous natural anti-oxidation nutrient, keep body antioxidant system and immune stable and normal function, prophylactic generation and prophylactic increasing the weight of.
2.2006 relevant seed of Fructus Hippophae extract component and correlational study document all are expressed as the Fructus Hippophae procyanidin before year.This is that the seed of Fructus Hippophae extract component is not made the inaccurate expression of going deep into chemical constitution research.
Goal of the invention:
Purpose of the present invention is to provide the Fructus Hippophae proanthocyanidin health product of a kind of antioxidation and enhancing immunity---plateau holy fruit board Fructus Hippophae proanthocyanidin soft capsule, and preparation method thereof.
Technical scheme of the present invention is as follows:
A prescription:
The health product of a kind of antioxidation and enhancing immunity is characterized in that: by seed of Fructus Hippophae proanthocyanidin extract 54 grams-300 grams, and Fructrs Hippophae seed oil 100 grams-450 grams, Oleum Perillae 100 grams-450 grams, Cera Flava (suspensoid) is 5% of a formula ratio.Make 1000 of the soft capsules of 0.45 gram/grain-1 gram/grain.
No. two schemes:
The health product of a kind of antioxidation and enhancing immunity is characterized in that: by seed of Fructus Hippophae proanthocyanidin extract 54 grams-300 grams, and Oleum Hippophae 100 grams-450 grams, Oleum Perillae 100 grams-450 grams, Cera Flava (suspensoid) is 5% of a formula ratio.Make 1000 of the soft capsules of 0.45 gram/grain-1 gram/grain.
The seed of Fructus Hippophae proanthocyanidin extract: for the seed of medicine-food two-purpose kind Fructus Hippophae through supercritical CO 2Seed of Fructus Hippophae slag behind the extraction Fructrs Hippophae seed oil, through the extract that the ethanol leach at low temperature obtains, this extract is main bioactive ingredients with the Fructus Hippophae proanthocyanidin.The chemical constitution of Fructus Hippophae proanthocyanidin is mainly former delphinidin and procyanidin.The Fructus Hippophae proanthocyanidin extract has antioxidation, removes human free radical, mutation, anticancer, blood fat reducing, blood sugar lowering, anticoagulant, antithrombotic form, and prevent arteriosclerosis, the ischemia resisting reperfusion injury, antiinflammatory, antiulcer, pharmacological actions such as antiviral and enhancing immunity.The seed of Fructus Hippophae proanthocyanidin extract is the antioxidant of efficiency natural safety, and the effect of seed of Fructus Hippophae proanthocyanidin inhibited oxidation is better than grape pip procyanidin.
Fructrs Hippophae seed oil: be the seed process supercritical CO of medicine-food two-purpose kind Fructus Hippophae 2The fatty oil of extraction contains multivitamin, several amino acids, multiple unsaturated fatty acid, flavone compound, phytosterin compound and the necessary trace element of multiple human body.Have pharmacological actions such as antioxidation, enhancing immunity, mutation, antitumor, antiinflammatory, radioprotective, blood fat reducing, the liver protecting and ALT lowering, slow down aging.
Oleum Hippophae: for the fruit drink of medicine-food two-purpose kind Fructus Hippophae through high speed centrifugation separate system fatty oil, contain multivitamin, several amino acids, multiple unsaturated fatty acid, flavone compound, phytosterin compound and the necessary trace element of multiple human body.Have pharmacological actions such as antioxidation, enhancing immunity, mutation, antitumor, antiinflammatory, radioprotective, the liver protecting and ALT lowering, drug resistance rerum natura myocardial damage.
Oleum Perillae: the fatty oil that gets through squeezing for medicine-food two-purpose kind Fructus Perillae.Oleum Perillae contains multiple fatty acid: wherein containing the linolenic acid mass fraction is 56.65%, the oleic acid mass fraction is 16.3%, the linoleic acid mass fraction is 13.1%, and the Palmic acid mass fraction only accounts for 6.61%, and visible Oleum Perillae is to plant the fatty acid mixed of being made up of a plurality of unsaturated double-bonds.Alpha-linolenic acid is classified as the needed by human nutrient by FAO (Food and Agriculture Organization of the United Nation) (FAO).Oleum Perillae have bring high blood pressure down, blood fat reducing, antiplatelet aggregation, antithrombotic, antiinflammatory, antiallergic, anticancer, antibacterial, antitussive, relieving asthma, pharmacological action such as resisting oxidation and delaying senility.
The compatibility explanation:
Product safety, effective, quality controllable be the most basic requirement of health caring product prescription.Seed of Fructus Hippophae proanthocyanidin extract, Fructrs Hippophae seed oil, Oleum Hippophae all are to extract with medicine-food two-purpose kind Fructus Hippophae to make.Oleum Perillae is to make with the squeezing of the Fructus Perillae of medicine-food two-purpose.The seed of Fructus Hippophae proanthocyanidin extract is as the antioxidant of efficiency natural, the function that significant antioxidation enhancing immunity is arranged, many-sided pharmacological actions such as blood fat reducing, anticoagulant, antithrombotic are arranged again, therefore choose the main component that the seed of Fructus Hippophae proanthocyanidin extract is an antioxidation enhancing immunity soft capsule.Fructrs Hippophae seed oil, Oleum Hippophae, Oleum Perillae all have the function of antioxidation enhancing immunity, as its composite composition, play the reinforcement synergism.Simultaneously, these fatty oils play the effect of bag thing seed of Fructus Hippophae proanthocyanidin extract powder carrier in the soft capsule again, make the oil meal suspensoid with seed of Fructus Hippophae proanthocyanidin extract powder, to satisfy the manufacturing technique requirent of the moving state of bag logistics in the soft capsule.
Its processing method is:
Prescription: purify the soft capsule workshop at 100,000 grades, Oleum Perillae in the above-mentioned prescription added to heat in the vacuum homogeneous emulsifying machine to 65 ℃ dissolve Cera Flava, be cooled to 30 ℃ of adding Fructrs Hippophae seed oil and seed of Fructus Hippophae proanthocyanidin extract and stirred homogenizing 0.5 hour, cross colloid mill 2 times, and be evacuated to no bubble, be cooled to the 60 mesh filter screen dischargings of 22 ℃ of mistakes to charging basket.Compacting soft gelatin capsule, soft gelatin capsule are finalized the design, wash ball, soft gelatin capsule drying, are selected ball, Nei Bao, quality inspection, packing.Stand-by.
No. two prescriptions: purify the soft capsule workshop at 100,000 grades, Oleum Perillae in the above-mentioned prescription added to heat in the vacuum homogeneous emulsifying machine to 65 ℃ dissolve Cera Flava, be cooled to 30 ℃ of adding Oleum Hippophaes and seed of Fructus Hippophae proanthocyanidin extract and stirred homogenizing 0.5 hour, cross colloid mill 2 times, and be evacuated to no bubble, be cooled to the 60 mesh filter screen dischargings of 22 ℃ of mistakes to charging basket.Compacting soft gelatin capsule, soft gelatin capsule are finalized the design, wash ball, soft gelatin capsule drying, are selected ball, Nei Bao, quality inspection, packing.Stand-by.
Useful result of the present invention:
With a prescription and No. two prescriptions that seed of Fructus Hippophae proanthocyanidin extract, Fructrs Hippophae seed oil or Oleum Hippophae, Oleum Perillae three flavor compatibilities become, make soft capsule, have very strong antioxidation enhancing immunity effect.Can strengthen anti-oxidation function and enhancing immunity in order to middle-aged and elderly people, immunocompromised person, radiation damage danger person, prevent the generation of multiple disease and increasing the weight of of the multiple disease of prevention.
The specific embodiment:
Embodiment 1: get seed of Fructus Hippophae proanthocyanidin extract 1.08Kg, Fructrs Hippophae seed oil 4.47Kg, Oleum Perillae 3Kg, Cera Flava 0.45Kg is at the soft capsule workshop of 100,000 grades of purifications, Oleum Perillae 3Kg in the above-mentioned prescription added to heat in the vacuum homogeneous emulsifying machine to 65 ℃ dissolve Cera Flava, be cooled to 30 ℃ and add Fructrs Hippophae seed oil 4.47Kg and seed of Fructus Hippophae proanthocyanidin extract 1.08Kg, stirred homogenizing 0.5 hour, cross colloid mill 2 times, and be evacuated to no bubble, be cooled to the 60 mesh filter screen dischargings of 22 ℃ of mistakes to charging basket.Compacting 0.45g/ seed lac ball, theoretical yield is 20000, and actual production is 19200, and the soft capsule yield rate is 96%.Soft gelatin capsule typing, wash ball, soft gelatin capsule drying, select ball, plastic-aluminum pressing plate packing, quality inspection, outer package.Stand-by.Make a kind of soft capsule of a prescription.
Embodiment 2: get seed of Fructus Hippophae proanthocyanidin extract 2.08Kg, Oleum Hippophae 4.27Kg, Oleum Perillae 6Kg, Cera Flava 0.65Kg is at the soft capsule workshop of 100,000 grades of purifications, Oleum Perillae 6Kg in the above-mentioned prescription added to heat in the vacuum homogeneous emulsifying machine to 65 ℃ dissolve Cera Flava, be cooled to 30 ℃ and add Oleum Hippophae 4.27Kg and seed of Fructus Hippophae proanthocyanidin extract 2.08Kg, stirred homogenizing 0.5 hour, cross colloid mill 2 times, and be evacuated to no bubble, be cooled to the 60 mesh filter screen dischargings of 22 ℃ of mistakes to charging basket.Compacting 0.65g/ seed lac ball, theoretical yield is 20000, and actual production is 19300, and the soft capsule yield rate is 96.5%.Soft gelatin capsule typing, wash ball, soft gelatin capsule drying, select ball, plastic-aluminum pressing plate packing, quality inspection, outer package.Stand-by.Make a kind of soft capsule of No. two prescriptions.
Functional component and content:
Every 100g contains proanthocyanidin 〉=6g
Suitable crowd:
Middle-aged and elderly people, hypoimmunity and radiation damage danger person
Using method and consumption:
Sooner or later (medicine) being taken before meal is used
0.45g/ grain, twice of every day, each 4
0.65g/ grain, twice of every day, each 2
The implementation result test
One. animal experiment
1. seed of Fructus Hippophae proanthocyanidin soft capsule anti-oxidation function test
Adopt SPF level Kunming kind aged mouse as experimental system, recommend 5,10,20 times of daily intaking amount 2.6g/60kg BW (being 0.04333g/kgBW) to be equivalent to the crowd, promptly 0.2167,0.4333,0.8667g/kgBW is respectively as basic, normal, high dosage group, establishes aged matched group and solvent control group simultaneously.The continuous per os of each dosage group mice is irritated stomach 30 days (aged matched group and solvent control group wait the distilled water and the soybean oil of capacity respectively), and result of the test shows:
1) the clear basic soft capsule of plateau holy fruit board Fructus Hippophae does not have obvious influence (p>0.05) to each dosage group aged mouse body weight;
2) high dose group can obviously reduce MDA content in aged mouse 1% liver homogenate, with aged matched group and solvent control group comparing difference significance (p<0.01, p<0.01) is arranged all;
3) SOD is active in high dose group aged mouse 1% liver homogenate raises, and with aged matched group and solvent control group comparing difference significance (p<0.05, p<0.05) is arranged all.
2. seed of Fructus Hippophae proanthocyanidin soft capsule enhancing immunity function test
Recommend daily intaking amount 0.0433g/kg.BW to enlarge 10,20,30 times by human body basic, normal, high three dosage groups are set, promptly 0.433,0.876,1.300g/kg.BW, other establishes negative control group and oil base matched group.Adopt SPF level Kunming mouse, the continuous irrigation stomach gives, and begins experiment after 30 days.Experimental result is judged as significant difference with P≤0.05, and the result shows: compare with oil base matched group and negative control group,
1) each dosage group mice body weight, lymphatic organ/there are no significant for the body weight ratio difference;
2) high dose group can obviously strengthen the inductive mice spleen lymphocytes proliferation ability of ConA;
3) high dose group can obviously strengthen the inductive mice delayed allergy of dinitrofluorobenzene;
4) the high dose group mice serum hemolysin content that can obviously raise;
5) high dose group obviously strengthens Turnover of Mouse Peritoneal Macrophages and engulfs the chicken red blood cell function;
6) high dose group obviously strengthens mice carbon and cleans up ability;
7) high dose group can obviously strengthen the antibody-producting cell ability;
Two. anti-oxidation function crowd test
Select age 45-65 year, healthy man, women's trial volunteer be totally 101 examples, is divided into matched group and test group (disengaging number 5 people, the disengaging rate is 4.7%) at random.All experimenters adhere to former life at duration of test, and diet is constant, and test group is recommended consumption every day 2 times according to the crowd, and each 2 (650mg/ grains) are taken and tried thing, continuous 3 months.The result shows: relatively lipid peroxide content decline 14.4% before and after the test group test-meal, superoxide dismutase raises 10.82%, glutathion peroxidase raises 3.78%, before and after self and with the matched group comparing difference significance (P<0.01 or 0.05) is arranged all.Test-meal before and after test group and matched group blood, urine, stool routine examination and blood biochemistry detection show no obvious abnormalities, and Chest X-rays, Abdominal B type ultrasonography, Electrocardioscopy result there is no unusually, illustrate that this test specimen has no adverse effects to experimenter's health.
Judge that according to " health food check and assessment technique standard " (2003) Fructus Hippophae anthocyanidin soft capsule has antioxidation.
Description of drawings:
Accompanying drawing is a process diagram of the present invention.

Claims (3)

1. the health product of antioxidation and enhancing immunity, it is characterized in that: by seed of Fructus Hippophae proanthocyanidin extract 54 grams-300 grams, Fructrs Hippophae seed oil 100 grams-450 grams, Oleum Perillae 100 grams-450 grams, Cera Flava (suspensoid) is 5% of a formula ratio, makes 1000 of the soft capsules of 0.45 gram/grain-1 gram/grain.
2. the health product of antioxidation and enhancing immunity, it is characterized in that: by seed of Fructus Hippophae proanthocyanidin extract 54 grams-300 grams, Oleum Hippophae 100 grams-450 grams, Oleum Perillae 100 grams-450 grams, Cera Flava (suspensoid) is 5% of a formula ratio, makes 1000 of the soft capsules of 0.45 gram/grain-1 gram/grain.
3. by claim 1 or 2 described health caring product prescriptions, it is characterized in that: the chemical constitution of seed of Fructus Hippophae proanthocyanidin extract is mainly former delphinidin, also contains procyanidin.
CN2010102143622A 2010-07-01 2010-07-01 Formula of health-care product for resisting oxidation and enhancing immunity Pending CN101961378A (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579591A (en) * 2011-12-20 2012-07-18 北京宝得瑞食品有限公司 Formula of health product for adjusting blood fat and reducing blood viscosity
CN102907677A (en) * 2012-11-14 2013-02-06 甘肃省轻工研究院 Sea-buckthorn perilla seed oil soft capsule having function of assisting blood-fat reduction and preparation method thereof
CN103598587A (en) * 2013-11-20 2014-02-26 山西振东制药股份有限公司 Health-care food with blood fat reduction assistance effect and preparation method thereof
CN103768276A (en) * 2014-02-19 2014-05-07 李海涛 Plant oligoprocyanidins composition superfine powder liniment for treating alopecia and preparation method of liniment
CN104000194A (en) * 2014-06-05 2014-08-27 南京瑞盈环保科技有限公司 Lotus seedpod procyanidins soft capsules capable of resisting oxidation and enhancing immunity and manufacturing method
CN104352736A (en) * 2014-11-25 2015-02-18 山西金科海生物制品有限公司 Medicinal and edible dual-purpose composition for preventing and treating vascular dementia and preparation method thereof
CN106176868A (en) * 2016-09-27 2016-12-07 乌鲁木齐上善元生物科技有限公司 A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof
CN107156332A (en) * 2017-06-22 2017-09-15 利康行(北京)生物科技有限公司 A kind of complex health care product of strengthen immunity

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579591A (en) * 2011-12-20 2012-07-18 北京宝得瑞食品有限公司 Formula of health product for adjusting blood fat and reducing blood viscosity
CN102579591B (en) * 2011-12-20 2014-12-24 北京宝得瑞食品有限公司 Health product for adjusting blood fat and reducing blood viscosity
CN102907677A (en) * 2012-11-14 2013-02-06 甘肃省轻工研究院 Sea-buckthorn perilla seed oil soft capsule having function of assisting blood-fat reduction and preparation method thereof
CN103598587A (en) * 2013-11-20 2014-02-26 山西振东制药股份有限公司 Health-care food with blood fat reduction assistance effect and preparation method thereof
CN103768276A (en) * 2014-02-19 2014-05-07 李海涛 Plant oligoprocyanidins composition superfine powder liniment for treating alopecia and preparation method of liniment
CN104000194A (en) * 2014-06-05 2014-08-27 南京瑞盈环保科技有限公司 Lotus seedpod procyanidins soft capsules capable of resisting oxidation and enhancing immunity and manufacturing method
CN104352736A (en) * 2014-11-25 2015-02-18 山西金科海生物制品有限公司 Medicinal and edible dual-purpose composition for preventing and treating vascular dementia and preparation method thereof
CN106176868A (en) * 2016-09-27 2016-12-07 乌鲁木齐上善元生物科技有限公司 A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof
CN107156332A (en) * 2017-06-22 2017-09-15 利康行(北京)生物科技有限公司 A kind of complex health care product of strengthen immunity

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Application publication date: 20110202