CN106176868A - A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof - Google Patents
A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof Download PDFInfo
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- CN106176868A CN106176868A CN201610851327.9A CN201610851327A CN106176868A CN 106176868 A CN106176868 A CN 106176868A CN 201610851327 A CN201610851327 A CN 201610851327A CN 106176868 A CN106176868 A CN 106176868A
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- soft capsule
- procyanidin
- carthamus yellow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
The invention discloses a kind of procyanidin Carthamus yellow composite soft capsule, be made up of soft capsule shell and content, described content includes safflower oil, procyanidin, Carthamus yellow, sodium alginate and Tween 80.Present invention also offers the preparation method of a kind of procyanidin Carthamus yellow composite soft capsule, including: in safflower oil, add sodium alginate and Tween 80, prepare suspension base oil；In suspension base oil, it is separately added into Carthamus yellow and procyanidin, prepares thick suspended oil；Thick suspended oil is carried out high pressure homogenize process；Prepare soft capsule shell liquid；After thick suspended oil after high pressure homogenize and soft capsule shell liquid being mixed, rolling molds ball, obtains composite soft capsule.Composite soft capsule prepared by the present invention has good treatment and prevention effect to cardiovascular and cerebrovascular diseases such as hearts, has enhancement memory, delaying senility and apoplexy, promotes cholesterol decomposition, skin care and health care, and technique is simple.
Description
Technical field
The present invention relates to technical field of medicine, it is more particularly related to a kind of procyanidin Flos Carthami yellow
Element composite soft capsule and preparation method thereof.
Background technology
Flos Carthami is the Chinese medicine of blood circulation promoting and blood stasis dispelling, and its promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing effect have certain generation in Chinese medicine
Table, the important Chinese medicine of the diseases of middle-and old-aged person such as prevention and treatment coronary heart disease, myocardial infarction and cerebral thrombosis time in modern medicine.Red
Rich in Carthamus yellow Flos Carthami red pigment in spending, Carthamus yellow is not only a kind of of great value natural food colour, tool
Have beautiful in colour, the advantage such as reduction high temperature resistant, high pressure resistant, low temperature resistant, fast light, acidproof, resistance to and antimicrobial, and also have expansion
The multiple pharmacological functions such as coronary artery, antioxidation, protection cardiac muscle, blood pressure lowering, immunosuppressant and brain protection.The most medically,
Carthamus yellow can be made soft capsule.Existing Carthamus yellow soft capsule function is more single, it is impossible to meets patient and is curing the disease
The most also there is the demand of health-care effect.
Summary of the invention
It is an object of the invention to solve at least the above, and the advantage that at least will be described later is provided.
A kind of procyanidin Carthamus yellow composite soft capsule, this compound flexible glue are it is a still further object of the present invention to provide
Capsule not only has treatment and prevention effect to cardiovascular and cerebrovascular diseases such as hearts, and also has enhancement memory, delaying senility with
And apoplexy, promote cholesterol decomposition, skin care and health care.
It is a still further object of the present invention to provide the preparation method of a kind of procyanidin Carthamus yellow composite soft capsule,
This preparation method is simple, and in this preparation method, the proportioning of each component ensure that the stability of each component in preparation process.
To achieve these goals, the invention provides a kind of procyanidin Carthamus yellow composite soft capsule, by flexible glue
Capsule softgel shell and the content composition being wrapped in described soft capsule shell, described by soft capsule shell and be wrapped in described soft capsule
Content composition in softgel shell, it is characterised in that described content includes safflower oil, procyanidin, Carthamus yellow, Sargassum
Acid sodium and Tween 80；
Described procyanidin and described Carthamus yellow summation, described sodium alginate, described Tween 80 and described Semen Flos Carthami
The weight ratio of oil is 10～20/6～10/0.1～0.5/100；The weight of described procyanidin and described Carthamus yellow it
Ratio is 3～7/7～3.Such as, described procyanidin is 3:7 with the weight ratio of described Carthamus yellow, or 7:3, or 1:
1, or 2:1.
Preferably, in described procyanidin Carthamus yellow composite soft capsule, described soft capsule shell include glycerol,
Gelatin, curcumin and water.
Preferably, in described procyanidin Carthamus yellow composite soft capsule, described procyanidin and described Flos Carthami
Flavochrome summation, described sodium alginate, described Tween 80 are 10/7/0.4/100 with the weight ratio of described safflower oil.
Present invention also offers the preparation method of a kind of procyanidin Carthamus yellow composite soft capsule, including following step
Rapid:
Step one, in safflower oil, it is separately added into sodium alginate and Tween 80, is ground to uniform rear chamber is gentle and quiet putting,
Remove insoluble matter, obtain suspension base oil；
Step 2, in described suspension base oil, it is separately added into graininess procyanidin and graininess Carthamus yellow, carries out
It is fully ground, obtains thick suspended oil；
Step 3, described thick suspended oil is carried out high pressure homogenize process；
Step 4, with gelatin, glycerol, curcumin and water as raw material, prepare soft capsule shell liquid；
Step 5, the thick suspended oil after high pressure homogenize and described soft capsule shell liquid are placed in couveuse, mix laggard
Row rolling molds ball, then performs sizing, washing and drying process, obtains procyanidin Carthamus yellow composite soft capsule.
Preferably, in the preparation method of described procyanidin Carthamus yellow composite soft capsule, described high pressure homogenize
It is processed as first described thick suspended oil being carried out homogenizing process, is then de-gassed process；
Wherein, homogenization pressure is 20Mpa, and homogenizing time is 20min；Degassing pressure is less than-0.10MPa, and degassing temperature is
90 DEG C～100 DEG C, degassing time is 2 hours.
Preferably, in the preparation method of described procyanidin Carthamus yellow composite soft capsule, described soft capsule
The preparation process of shell liquid is:
S1, according to gelatin: glycerol: the weight ratio of water be 1:0.3～0.5:1 relation another name take gelatin, G & W,
And weigh described gelatin, G & W gross weight 0.2% curcumin；
S2, gelatin is placed in part water to carry out being dipped to described gelatin the most swelling, obtains gelatin solution；
S3, residue water is mixed with glycerol it is placed in glue pot, and be heated to 70 DEG C, be subsequently adding described gelatin solution,
Stirring 1～1.5h is allowed to melt completely uniformly, adds curcumin, and stirring makes mix homogeneously, lets cool to 60 DEG C, and at 60 DEG C
Carry out insulation to stand, remove the foam floated, after filtration, obtain soft capsule shell liquid.
Preferably, in the preparation method of described procyanidin Carthamus yellow composite soft capsule, described rolling molds ball
Temperature be 75～80 DEG C.
Preferably, in the preparation method of described procyanidin Carthamus yellow composite soft capsule, described sizing, washing
With drying process particularly as follows:
After rolling molds ball, the pill-rolling 8h that dries at 20 DEG C, with sizing, obtains soft capsule；Wash in washing pill wiping machine with ethanol
Remove soft capsule surface oil reservoir, and dry up the washing liquid on soft capsule surface；Soft capsule after washing is dried up 6 hours in net machine,
To procyanidin Carthamus yellow composite soft capsule.
Preferably, in the preparation method of described procyanidin Carthamus yellow composite soft capsule, described part water and
The weight ratio of described residue water is 4:1.
Preferably, in the preparation method of described procyanidin Carthamus yellow composite soft capsule, described graininess is red
The mesh number of anthoxanthin and graininess procyanidin is 200 mesh.
The present invention at least includes following beneficial effect:
1, procyanidin Carthamus yellow composite soft capsule of the present invention is not only to cardiovascular and cerebrovascular disease tools such as hearts
There is good treatment and prevention effect, and also there is enhancement memory, delaying senility and apoplexy, promote cholesterol decomposition,
Skin care and health care.
2, the preparation method of procyanidin Carthamus yellow composite soft capsule of the present invention, this preparation method can be made
The standby composite soft capsule obtaining stable performance, and there is the simple advantage of technique.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will be by this
Invention research and practice and be understood by the person skilled in the art.
Accompanying drawing explanation
Fig. 1 is the preparation side of the procyanidin Carthamus yellow composite soft capsule described in one of them embodiment of the present invention
The flow chart of method.
Detailed description of the invention
Below in conjunction with the accompanying drawings and embodiment the present invention is described in further detail, to make those skilled in the art join
Book word can be implemented according to this as directed.
Should be appreciated that used herein such as " have ", " comprising " and " including " term are not precluded from one or many
Other element individual or the existence of a combination thereof or interpolation.
The invention provides a kind of procyanidin Carthamus yellow composite soft capsule, by soft capsule shell be wrapped in described
Content composition in soft capsule shell, described content includes safflower oil, sodium alginate, Tween 80, procyanidin and
Carthamus yellow；Described soft capsule shell includes glycerol, gelatin, curcumin and water.
(1) in order to inquire in content the relation between the weight of each component and the selection of suspending agent, carried out as follows
Experiment: 1, the selection of suspending agent
This suspension test with granularity less than the pigment granule of 200 mesh as raw material, (pigment granule be Carthamus yellow granule or
Procyanidin granule), with safflower oil as base oil, suspending agent is suspending agent CMC, sodium alginate, glycerol, xanthan gum, two oleic acid
Glyceride, sucrose fatty acid ester, Tween 80, soybean phospholipid, be respectively put into above-mentioned helping by raw material and base oil according to the ratio of 1:20
In suspension, homogenizing (20Mpa) 20 minutes after colloid mill, stand, record separation time, reach more than 72h for expection effect with stabilization time
Really, suspension result is as shown in Table 1 and Table 2:
The suspension effect of table 1. part suspending agent
The suspension effect of table 2. remainder suspending agent
Interpretation of result, in above-mentioned 8 suspending agents, or is shorter than 3 hours stabilization time, or produces the most runny precipitate
Matter, effect preferably sodium alginate and the moiety concentrations of Tween 80, the sodium alginate suspending stablizing effect with 1/20 is best, can
Reach 24h, but still homogeneous capsule can not be met and make requirement.
2, suspension base oil compounds suspending test
On the basis of fixing main suspending agent sodium alginate (1/20), add the most commensurability Tween 80 for auxiliary suspension, side
The same single factor test of method.
Table 3. adds variable concentrations auxiliary suspension Tween 80 effect on the basis of suspending agent sodium alginate (1/20)
| Numbering | Suspension | Adding proportion (adjuvant w/ safflower oil w) | Obvious separation time (h) occurs | Satellite phenomenon |
| Comparison | — | — | 24 | |
| 1 | Tween 80 | 1/500 | 48 | |
| 2 | Tween 80 | 1/400 | 60 | |
| 3 | Tween 80 | 1/300 | 120 | |
| 4 | Tween 80 | 1/200 | 120 | |
| 5 | Tween 80 | 1/100 | 120 | Precipitation occurs |
On the basis of 1/20 sodium alginate, Tween 80 effect in the range of 1/200-1/300 adds is preferable, effect suspension stabilization
Time, more than 72 hours, meets capsule and makes demand stabilization time；When Tween 80 reaches 1/100, a certain amount of precipitation occurs, easily
Blocking spray orifice.
3, the Carthamus yellow granularity impact on suspension effect
With FSJ-1 super micron mill, Carthamus yellow is carried out micronizing, choose granularity be respectively 100 mesh, 160 mesh,
200 mesh, 240 mesh, the graded particie of 300 mesh carry out suspension test, investigate method ibid, and compound suspending agent addition is 1/20 sea
Sodium alginate+1/200 Tween 80.There is significantly impact in the granularity of the Carthamus yellow in table 4, when granularity reaches on suspension effect
To 200 mesh or above time, stabilization time be more than 72h.
The impact on suspension effect of the table 4. Carthamus yellow granularity
| Numbering | Granularity (mesh) | Adding proportion (w/ safflower oil w) | Obvious separation time (h) occurs | Satellite phenomenon |
| 1 | 100 | 1/20 | 48 | |
| 2 | 160 | 1/20 | 60 | |
| 3 | 200 | 1/20 | 120 | |
| 4 | 240 | 1/20 | 148 | |
| 5 | 300 | 1/20 | 148 |
4, homogenization pressure and the time impact on suspension effect
Select 5,10,15,20,25,30Mpa homogenization pressure, add suspending agent 1/20 sodium alginate+1/200 Tween 80, powder
Expect 200 mesh, with granularity less than the Carthamus yellow of 200 mesh and procyanidin as raw material, with safflower oil as base oil, raw material and base
The weight ratio of oil is 1/20, and homogenizing time 20min carries out stability test, the results are shown in Table 5.
The impact on suspension effect of table 5. homogenization pressure
| Numbering | Homogenization pressure (Mpa) | Obvious separation time (h) occurs | Remarks/satellite phenomenon |
| 1 | 5 | 48 | Occur after 12h that paste precipitates |
| 2 | 10 | 60 | |
| 3 | 15 | 120 | |
| 4 | 20 | 120 | |
| 5 | 25 | 120 | |
| 6 | 30 | 120 |
Homogenization pressure i.e. can reach expection stablizing effect at more than 15Mp, it is considered to later stage material ratio increased, therefore
Set 20Mpa as operation pressure.
Fixing homogenization pressure is 20Mpa, carries out homogenizing time to stability influence, and condition is ibid.The results are shown in Table 6.
The impact on suspension effect of table 6. homogenizing time
| Numbering | Homogenizing time (min) | Obvious separation time (h) occurs | Remarks/satellite phenomenon |
| 1 | 5 | 48 | Occur after 24h that paste precipitates |
| 2 | 10 | 120 | |
| 3 | 15 | 120 | |
| 4 | 20 | 120 | |
| 5 | 25 | 120 | |
| 6 | 30 | 120 |
Under 20Mpa pressure, more than homogenizing time 10min i.e. can reach requirement.Consider that material ratio increases factor, fixing
Processing condition is: 20Mpa, 15min.
5, raw material/base oil ratio impact on suspension effect
Select 1/30,1/25,1/20,1/15,1/10,1/5 5 part by weight, add suspending agent 1/20 sodium alginate+
1/200 Tween 80, powder 200 mesh, homogenization pressure 20Mpa, time 15min, Carthamus yellow and the weight of procyanidin in raw material
Amount ratio is 3～7/7～3, carries out stability test, the results are shown in Table 7: material/oil additional proportion is relatively big, when stablizing to stability influence
Between relatively big with suspended oil character difference, optimal with 1/20, pasty state capsule suspending agent 1/15-1/20 material oil than.
The impact of table 7. raw materials/base oil comparison suspension effect
| Numbering | Material/oil is than (w/w) | Obvious separation time (h) occurs | Remarks/satellite phenomenon |
| 1 | 1/30 | 24 | Oil preparation |
| 2 | 1/25 | 84 | Oil preparation |
| 3 | 1/20 | 120 | Oil preparation |
| 4 | 1/15 | 240 | Pasty state |
| 5 | 1/10 | 240 | Pasty state |
| 6 | 1/5 | — | Paste, it is impossible to homogenizing |
(2) orthogonal test and optimal suspended oil technological design
(more than 72h) in the range of Effective Suspension, choose and affect three principal elements that suspending agent is stable: suspending agent Sargassum
Acid sodium addition, auxiliary suspension Tween 80 addition, material oil ratio, design orthogonal test.Powder 200 mesh used, homogenization pressure
20Mpa, time 15min, carry out Detection of Stability.EXPERIMENTAL DESIGN and the results are shown in Table 8, the results of analysis of variance is shown in Table 9.
Table 8 suspension effect orthogonal experiments
Table 9 suspension effect orthogonal test variance analysis
| Factor | Sum of square of deviations | Degree of freedom | F ratio | F marginal value |
| Sodium alginate | 2144 | 2 | 1.367 | 19 |
| Tween 80 | 5792 | 2 | 3.694 | 19 |
| Material oil ratio | 3584 | 2 | 2.286 | 19 |
| Empty row | 1568 | 2 | 1.000 | 19 |
| Error | 1568 | 2 |
From table 8 and table 9, three factors affecting suspended oil stabilization time selected in this orthogonal test are all to result
Having a significant impact, its significance size order is: Tween 80 addition > material oil ratio > sodium alginate addition, hangs for reaching to extend
Floating have stabilization time, the purpose preventing it to be layered, and its best of breed selects A2B2C3, i.e. sodium alginate addition to be 1/15, helps
Suspension Tween 80 addition is 1/275, and material oil ratio is 1/10.Tested by checking, should under the conditions of, suspended oil stabilization time up to
More than 264h.
Discussion based on above-mentioned experiment condition, present invention determine that the technological parameter of proportioning raw materials and each step, as
Shown in Fig. 1, present invention also offers the preparation method of a kind of procyanidin Carthamus yellow composite soft capsule, including following step
Rapid:
Step one, in safflower oil, it is separately added into sodium alginate and Tween 80, is ground to uniform rear chamber is gentle and quiet putting,
Remove insoluble matter, obtain suspension base oil；
Step 2, in described suspension base oil, it is separately added into graininess procyanidin and graininess Carthamus yellow, carries out
It is fully ground, obtains thick suspended oil；
Step 3, described thick suspended oil is carried out high pressure homogenize process: first described thick suspended oil is carried out homogenizing process, so
After be de-gassed process；Wherein, homogenization pressure is 20Mpa, and homogenizing time is 20min；Degassing pressure is less than-0.10MPa, degassing
Temperature is 90 DEG C～100 DEG C, and degassing time is 2 hours；
Step 4, with gelatin, glycerol, curcumin and water as raw material, prepare soft capsule shell liquid；
By gelatin: glycerol: the amount of water=2:0.8:2 weighs gelatin, glycerol, water, and weighs glycerol, gelatin, water inventory
0.2% curcumin；After gelatin first makes it the most swelling with about 80% water soaking；Residue water is mixed with glycerol, puts and boil glue
Being heated to 70 DEG C in Guo, add gelatin solution, stirring is allowed to melt uniform about 1～1.5h completely, adds curcumin, and stirring makes mixing
Uniformly, letting cool, be incubated 60 DEG C of standings, remove the foam floated, filter, obtain soft capsule shell liquid, viscosity is about 40mps-1Left
Right.
Step 5, the thick suspended oil after high pressure homogenize and described soft capsule shell liquid are placed in couveuse, mix laggard
Row rolling molds ball, then performs sizing, washing and drying process, obtains procyanidin Carthamus yellow composite soft capsule:
Such as according to the relation that weight ratio is 2～3:1 of the thick suspended oil after soft capsule shell liquid and homogenizing, by above-mentioned soft
Thick suspended oil after capsule capsule shell fluid and homogenizing puts into couveuse, carries out rolling and molds ball, and temperature is maintained between 75～80 DEG C
Rolling molds ball.In production process, control pelleting temperature 35 DEG C～40 DEG C, roll mould rotating speed about 3 revs/min；Control indoor temperature to exist
20 DEG C～25 DEG C.Relative air humidity less than 40%；Blowing pill-rolling 8h setting shaping at 20 DEG C；Wash at shampooing ball machine with ethanol
Remove capsule surface oil layer, dry up washing liquid；Soft capsule after washing with alcohol is dried up about 6 hours in net machine.
And pick ball: dried composite soft capsule is manually picked ball or machinery picks ball, pick big piller, abnormity
Ball, obvious wire mark ball, leakage ball, flat ball, thin-walled ball, bubble ball etc., put into the appearance of clean dried by qualified composite soft capsule ball
In device, weigh, name of product, weight, lot number, date should be indicated with Status Flag, add a cover envelope with stainless steel cask outside container
Good.
Inspection, packaging: take above-mentioned composite soft capsule censorship, qualified rear subpackage.
Procyanidin Carthamus yellow composite soft capsule prepared by the present invention combines Carthamus yellow and procyanidin
Advantage, Carthamus yellow has the effects such as promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, reduction cholesterol, blood pressure lowering, is mainly used in menstruation not
Tune, dysmenorrhea, amenorrhea, traumatic injury, also have certain curative effect to the disease such as coronary heart disease, infectious hepatitis, also expands crown dynamic
The multiple pharmacological functions such as arteries and veins, antioxidation, protection cardiac muscle, blood pressure lowering, immunosuppressant and brain protection, procyanidin also has guarantor simultaneously
Protecting action of the heart, therefore the combination of Carthamus yellow and procyanidin can strengthen the curative effect to heart disease and coronary heart disease, with
Time this composite soft capsule also there is enhancement memory, delaying senility and apoplexy, promote cholesterol decomposition, skin care and guarantor
Health-care function.
Although embodiment of the present invention are disclosed as above, but it is not restricted in description and embodiment listed
Using, it can be applied to various applicable the field of the invention completely, for those skilled in the art, and can be easily
Realizing other amendment, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention does not limit
In specific details and shown here as the legend with description.
Claims (10)
1. a procyanidin Carthamus yellow composite soft capsule, by soft capsule shell and being wrapped in described soft capsule shell
Content form, it is characterised in that described content include safflower oil, procyanidin, Carthamus yellow, sodium alginate and
Tween 80；
Described procyanidin and described Carthamus yellow summation, described sodium alginate, described Tween 80 and described safflower oil
Weight ratio is 10～20/6～10/0.1～0.5/100；Described procyanidin is 3 with the weight ratio of described Carthamus yellow
～7/7～3.
2. procyanidin Carthamus yellow composite soft capsule as claimed in claim 1, it is characterised in that described soft capsule shell
Including glycerol, gelatin, curcumin and water.
3. procyanidin Carthamus yellow composite soft capsule as claimed in claim 1, it is characterised in that described procyanidin with
Described Carthamus yellow summation, described sodium alginate, described Tween 80 are 10/7/0.4/ with the weight ratio of described safflower oil
100。
4. the method preparing procyanidin Carthamus yellow composite soft capsule as described in any one of claims 1 to 3, its
It is characterised by, comprises the following steps:
Step one, in safflower oil, it is separately added into sodium alginate and Tween 80, is ground to uniform rear chamber is gentle and quiet putting, remove
Insoluble matter, obtains suspension base oil；
Step 2, in described suspension base oil, it is separately added into graininess procyanidin and graininess Carthamus yellow, carries out fully
Grind, obtain thick suspended oil；
Step 3, described thick suspended oil is carried out high pressure homogenize process；
Step 4, with gelatin, glycerol, curcumin and water as raw material, prepare soft capsule shell liquid；
Step 5, the thick suspended oil after high pressure homogenize and described soft capsule shell liquid are placed in couveuse, roll after mixing
Mold ball, then perform sizing, washing and drying process, obtain procyanidin Carthamus yellow composite soft capsule.
5. the preparation method of procyanidin Carthamus yellow composite soft capsule as claimed in claim 4, it is characterised in that described
High pressure homogenize is processed as first described thick suspended oil being carried out homogenizing process, is then de-gassed process；
Wherein, homogenization pressure is 20Mpa, and homogenizing time is 20min；Degassing pressure is less than-0.10MPa, and degassing temperature is 90 DEG C
～100 DEG C, degassing time is 2 hours.
6. the preparation method of procyanidin Carthamus yellow composite soft capsule as claimed in claim 4, it is characterised in that described
The preparation process of soft capsule shell liquid is:
S1, according to gelatin: glycerol: the weight ratio of water is that the relation another name of 1:0.3～0.5:1 takes gelatin, G & W, and claims
Take described gelatin, G & W gross weight 0.2% curcumin；
S2, gelatin is placed in part water to carry out being dipped to described gelatin the most swelling, obtains gelatin solution；
S3, residue water is mixed with glycerol it is placed in glue pot, and be heated to 70 DEG C, be subsequently adding described gelatin solution, stir 1
～1.5h is allowed to melt completely uniformly, adding curcumin, stirring makes mix homogeneously, lets cool to 60 DEG C, and carry out at 60 DEG C
Insulation stands, and removes the foam floated, and obtains soft capsule shell liquid after filtration.
7. the preparation method of procyanidin Carthamus yellow composite soft capsule as claimed in claim 4, it is characterised in that described
It is 75～80 DEG C that rolling molds the temperature of ball.
8. the preparation method of procyanidin Carthamus yellow composite soft capsule as claimed in claim 4, it is characterised in that described
Sizing, washing and drying process particularly as follows:
After rolling molds ball, the pill-rolling 8h that dries at 20 DEG C, with sizing, obtains soft capsule；Wash away soft in washing pill wiping machine with ethanol
Capsule surface oil reservoir, and dry up the washing liquid on soft capsule surface；Soft capsule after washing is dried up 6 hours in net machine, obtains former
Anthocyanidin Carthamus yellow composite soft capsule.
9. the preparation method of procyanidin Carthamus yellow composite soft capsule as claimed in claim 6, it is characterised in that described
The weight ratio of part water and described residue water is 4:1.
10. the preparation method of procyanidin Carthamus yellow composite soft capsule as claimed in claim 4, it is characterised in that institute
The mesh number stating graininess Carthamus yellow and graininess procyanidin is 200 mesh.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610851327.9A CN106176868A (en) | 2016-09-27 | 2016-09-27 | A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof |
Applications Claiming Priority (1)
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| CN107149610A (en) * | 2017-05-24 | 2017-09-12 | 新疆宏展特色农业科技开发有限公司 | A kind of cynomorium songaricum capsule and preparation method thereof |
| CN107412349A (en) * | 2017-05-24 | 2017-12-01 | 新疆宏展特色农业科技开发有限公司 | A kind of saline cistanche capsule and preparation method thereof |
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Application publication date: 20161207 |