CN107412349A - A kind of saline cistanche capsule and preparation method thereof - Google Patents
A kind of saline cistanche capsule and preparation method thereof Download PDFInfo
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- CN107412349A CN107412349A CN201710373414.2A CN201710373414A CN107412349A CN 107412349 A CN107412349 A CN 107412349A CN 201710373414 A CN201710373414 A CN 201710373414A CN 107412349 A CN107412349 A CN 107412349A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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Abstract
The invention discloses a kind of saline cistanche capsule, it is made up of capsule softgel shell and content, the content includes cistanche extracts, safflower seed oil, OPC, vitamin E, the first suspending agent and the second suspending agent；The capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water.The invention also discloses the preparation method of saline cistanche capsule, including：Prepare granular cistanche extracts；The first suspending agent and the second suspending agent are added into safflower seed oil, obtains suspension base oil；Vitamin E, OPC and cistanche extracts are added into the suspension base oil, obtain thick suspended oil；Prepare capsule capsule shell fluid；Thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, rolling molding ball, sizing, washing and drying are carried out after well mixed.Saline cistanche capsule prepared by the present invention has the effect of tonifying kidney and strengthening yang, Tianjing Busuiye medicinal, enriching the blood to restore normal menstruation, anti-oxidant, anti-aging, strengthen immunity, relieving sore-throat clearing, in good taste and good absorbing.
Description
Technical field
The present invention relates to technical field of medicine, it is more particularly related to a kind of saline cistanche capsule and its system
Preparation Method.
Background technology
Saline cistanche, alias great Yun, boundary rue, very little rue, desert cistanche, look into it is dry accuse it is sub-.The good reputation of " desert ginseng " is known as, is had high
Medical value, be Chinese tradition rare traditional Chinese medicine.Saline cistanche is sweet, warm-natured, has tonifying kidney and strengthening yang, Tianjing Busuiye medicinal, blood-nourishing
Moisturize, please color macrobiosis and other effects.Saline cistanche medicine-food two-purpose, long-term consumption can increase muscle power, enhancing endurance and resisting fatigue, together
When can strengthen the sexuality and fertility of the mankind and animal again.Saline cistanche is in history just by Western Regions various countries as Shang Gong imperial court
Treasure, and one of usage frequency highest help medicine in successive dynasties tonifying kidney and strengthening yang class prescription.Saline cistanche has regulation nerve
It is internal system and the effect of tonifying the kidney and support yang, wind-damp dispelling effect, functions of loosening bowel relieving constipation, the microcirculation of regulation tissue, anti-oxidant, anti-tired
Labor, the effect for strengthening immunologic function.But the direct eating mouth feel of saline cistanche is poor, and absorptivity is relatively low, it is impossible to farthest hair
Wave its medicinal efficacy.
Application publication number is that CN 106473038A Chinese patent discloses a kind of saline cistanche health-care tablet and its preparation side
Method, using the cistanche extracts for extracting to obtain from saline cistanche as raw material, and tablet is made, although mouthfeel is better than directly edible
Saline cistanche, but remain the problem of health-care effect is bad and mouthfeel is bad.
The content of the invention
It is an object of the invention to solve at least the above, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide a kind of saline cistanche capsule, the saline cistanche capsule is soft capsule, and can
Ensure the suspension degree of the uniformity and solid particle of the content in capsule softgel shell in oil, substantially increase saline cistanche capsule
Stability, while the saline cistanche capsule also there is tonifying kidney and strengthening yang, Tianjing Busuiye medicinal, enriching the blood to restore normal menstruation, anti-oxidant, anti-aging, enhancing to exempt from
The effect of epidemic disease power, relieving sore-throat clearing, in good taste and good absorbing.
It is a still further object of the present invention to provide a kind of preparation method of saline cistanche capsule, its preparation method is simple, together
When the preparation method can ensure the stability of saline cistanche capsule, ensure that the medical value and health value of saline cistanche capsule,
Guarantor's body can effectively absorb the drug effect of the content of saline cistanche capsule.
To achieve these goals, the invention provides a kind of saline cistanche capsule, by capsule softgel shell and it is wrapped in the glue
Content composition in capsule softgel shell, the content include cistanche extracts, safflower seed oil, OPC, vitamin E, the
One suspending agent and the second suspending agent；The capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water.
Preferably, wherein, the content includes the component of following parts by weight：
15~25 parts of cistanche extracts, 100~200 parts of safflower seed oil, 10~20 parts of OPC, vitamin E2~6
Part, the first 0.01~0.8 part of suspending agent, the second 0.01~0.5 part of suspending agent.
Preferably, wherein, the content includes the component of following parts by weight：
16~22 parts of cistanche extracts, 100~170 parts of safflower seed oil, 12~18 parts of OPC, vitamin E2~4
Part, 0.01~0.6 part of the first suspending agent, the second 0.01~0.1 part of suspending agent.
Preferably, wherein, the content includes the component of following parts by weight：
18 parts of cistanche extracts, 150 parts of safflower seed oil, 15 parts of OPC, vitamin E2 part, the first suspending agent 0.1
Part, the second 0.02 part of suspending agent.
Preferably, wherein, first suspending agent is sucrose fatty ester, and second suspending agent is xanthans.
Preferably, wherein, glycerine in the capsule softgel shell, gelatin, the mass ratio of mint juice and water are 0.2~0.4/
1/0.2~0.4/0.6~0.8, the quality of the curcumin are the 0.3% of glycerine, gelatin, mint juice and water gross weight.
The invention also discloses a kind of preparation method of saline cistanche capsule, comprise the following steps：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Step 2: adding the first suspending agent and the second suspending agent into safflower seed oil, it is stored at room temperature, removes after grinding uniformly
Insoluble matter, obtain suspension base oil；
Carried Step 3: adding vitamin E, granular OPC and granular saline cistanche into the suspension base oil
Thing is taken, is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, the thick suspended oil is carried out high-pressure homogeneous
Processing；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, after being well mixed
Rolling molding ball, sizing, washing and drying are carried out, obtains saline cistanche capsule.
Preferably, wherein, in the step 1, the preparation process of the granular cistanche extracts is：
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 100~200 mesh；
Extraction：50~70v% ethanol solutions of 2~4 times of weight are added into the saline cistanche coarse powder of 100~200 mesh,
60~80 DEG C of 2~4h of holding are heated to, filter residue and filtrate is filtered to obtain, filter residue is washed using 50~70v% ethanol solutions,
Merge cleaning solution and filtrate, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, ethanol is reclaimed, graininess cistanche extracts is obtained after being concentrated to dryness.
Preferably, wherein, in the step 4, the preparation process of the capsule capsule shell fluid is：
S1, according to the mass ratio of glycerine, gelatin, mint juice and water for 0.2~0.4/1/0.2~0.4/0.6~0.8
Relation also known as takes glycerine, gelatin, mint juice and water, and weighs 0.3% ginger of gelatin, glycerine, mint juice and water gross weight
Flavine；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin solution,
0.8~1.2h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and 60
Insulation standing is carried out at DEG C, removes the foam of floating, capsule capsule shell fluid is obtained after filtering.
Preferably, wherein, in the step 5, the sizing, washing and drying process are specially：
After rolling is molded ball, the pill-rolling 6h that dried at 25 DEG C obtains capsule to shape；
Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；
By the capsule after washing in being dried up 4 hours in net machine, saline cistanche capsule is obtained.
The present invention comprises at least following beneficial effect：
1st, the cistanche extracts in the content of saline cistanche capsule of the present invention have regulation neuroendocrine system
Unite and tonify the kidney and support yang effect, wind-damp dispelling effect, functions of loosening bowel relieving constipation, regulation tissue microcirculation, anti-oxidant, antifatigue, enhancing is exempted from
The effect of epidemic disease function, vitamin E and OPC are respectively provided with the effect of anti-aging, and the first suspending agent and the second suspending agent can be protected
Card each component can be suspended in safflower seed oil for a long time, and the weight proportion of other components so that saline cistanche capsule has
There are excellent health properties, include mint juice in the capsule softgel shell of saline cistanche capsule, substantially increase saline cistanche capsule and taking
When mouthfeel, while there is the effect of relieving sore-throat and clearing.
2nd, the preparation method of saline cistanche capsule provided by the invention is simple, and raw material is cheap and easy to get, reduces production cost, real
The industrialization for having showed saline cistanche capsule quickly produces.
3rd, the extracting method of cistanche extracts provided by the invention can ensure the recovery rate of cistanche extracts and pure
Degree, ensure that the health-care efficacy of cistanche extracts.
Further advantage, target and the feature of the present invention embodies part by following explanation, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Embodiment
With reference to specific embodiment, the present invention is described in further detail, to make those skilled in the art's reference say
Bright book word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded from one or more
The presence or addition of individual other elements or its combination.
Embodiment 1：
The invention provides a kind of saline cistanche capsule, by capsule softgel shell and the content group being wrapped in the capsule softgel shell
Into the parts by weight of each component in content are：15 parts of cistanche extracts, 200 parts of safflower seed oil, 20 parts of OPC,
0.01 part of 6 parts of vitamin E, 0.8 part of sucrose fatty ester and xanthans；
Capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water, wherein, glycerine, gelatin, mint juice and water
Mass ratio be 0.2:1:0.2:0.6, the quality of curcumin is the 0.3% of glycerine, gelatin, mint juice and water gross weight.
The invention also discloses a kind of preparation method of saline cistanche capsule, comprise the following steps：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 150 mesh；
Extraction：50~70v% ethanol solutions of 2 times of weight are added into the saline cistanche coarse powder of 150 mesh, are heated to 60
DEG C keep 2~4h, filter to obtain filter residue and filtrate, filter residue washed using 50~70v% ethanol solutions, merge cleaning solution and
Filtrate, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, reclaims ethanol, the cistanche extracts of 200 mesh are obtained after being concentrated to dryness.
Step 2: adding sucrose fatty ester and xanthans into safflower seed oil, it is stored at room temperature, is removed not after grinding uniformly
Molten thing, obtain suspension base oil；
Step 3: the saline cistanche extraction of vitamin E, the OPC of 200 mesh and 200 mesh is added into the suspension base oil
Thing, it is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, high-pressure homogeneous place is carried out to the thick suspended oil
Reason；Homogenization pressure is 18Mpa, homogenizing time 22min；Degassing pressure is less than -0.10MPa, and degassing temperature is 97 DEG C, during degassing
Between be 2 hours；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
S1, according to glycerine, gelatin, mint juice and water mass ratio be 0.2:1:0.2:0.6 relation also known as takes sweet
Oil, gelatin, mint juice and water, and weigh 0.3% curcumin of gelatin, glycerine, mint juice and water gross weight；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin solution,
0.8~1.2h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and 60
Insulation standing is carried out at DEG C, removes the foam of floating, capsule capsule shell fluid is obtained after filtering
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, after being well mixed
Rolling molding ball, sizing, washing and drying are carried out, obtains saline cistanche capsule.Rolling be molded ball after, at 25 DEG C dry pill-rolling 6h with
Sizing, obtains capsule；Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；Will washing
Capsule afterwards obtains saline cistanche capsule in being dried up 4 hours in net machine.
Embodiment 2：
The invention provides a kind of saline cistanche capsule, by capsule softgel shell and the content group being wrapped in the capsule softgel shell
Into the parts by weight of each component in content are：25 parts of cistanche extracts, 100 parts of safflower seed oil, 10 parts of OPC,
0.5 part of vitamin E2 part, 0.01 part of sucrose fatty ester and xanthans；
Capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water, wherein, glycerine, gelatin, mint juice and water
Mass ratio be 0.4:1:0.4:0.8, the quality of curcumin is the 0.3% of glycerine, gelatin, mint juice and water gross weight.
The invention also discloses a kind of preparation method of saline cistanche capsule, comprise the following steps：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 200 mesh；
Extraction：50~70v% ethanol solutions of 4 times of weight are added into the saline cistanche coarse powder of 200 mesh, are heated to 80
DEG C 2h is kept, filter to obtain filter residue and filtrate, filter residue is washed using 50~70v% ethanol solutions, merge cleaning solution and filter
Liquid, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, reclaims ethanol, the cistanche extracts of 200 mesh are obtained after being concentrated to dryness.
Step 2: adding sucrose fatty ester and xanthans into safflower seed oil, it is stored at room temperature, is removed not after grinding uniformly
Molten thing, obtain suspension base oil；
Step 3: the saline cistanche extraction of vitamin E, the OPC of 200 mesh and 200 mesh is added into the suspension base oil
Thing, it is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, high-pressure homogeneous place is carried out to the thick suspended oil
Reason；Homogenization pressure is 18Mpa, homogenizing time 22min；Degassing pressure is less than -0.10MPa, and degassing temperature is 97 DEG C, during degassing
Between be 2 hours；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
S1, according to glycerine, gelatin, mint juice and water mass ratio be 0.4:1:0.4:0.8 relation also known as takes bright
Glue, glycerine, mint juice and water, and weigh 0.3% curcumin of gelatin, glycerine, mint juice and water gross weight；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin solution,
0.8~1.2h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and 60
Insulation standing is carried out at DEG C, removes the foam of floating, capsule capsule shell fluid is obtained after filtering.
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, after being well mixed
Rolling molding ball, sizing, washing and drying are carried out, obtains saline cistanche capsule.Rolling be molded ball after, at 25 DEG C dry pill-rolling 6h with
Sizing, obtains capsule；Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；Will washing
Capsule afterwards obtains saline cistanche capsule in being dried up 4 hours in net machine.
Embodiment 3：
The invention provides a kind of saline cistanche capsule, by capsule softgel shell and the content group being wrapped in the capsule softgel shell
Into the parts by weight of each component in content are：16 parts of cistanche extracts, 100 parts of safflower seed oil, 12 parts of OPC,
0.01 part of 4 parts of vitamin E, 0.6 part of sucrose fatty ester and xanthans；
Capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water, wherein, glycerine, gelatin, mint juice and water
Mass ratio be 0.3:1:0.4:0.7, the quality of curcumin is the 0.3% of glycerine, gelatin, mint juice and water gross weight.
The invention also discloses a kind of preparation method of saline cistanche capsule, comprise the following steps：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 100 mesh；
Extraction：50~70v% ethanol solutions of 2.5 times of weight are added into the saline cistanche coarse powder of 100 mesh, are heated to
65 DEG C of 2~4h of holding, are filtered to obtain filter residue and filtrate, filter residue are washed using 50~70v% ethanol solutions, merge cleaning solution
And filtrate, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, reclaims ethanol, the cistanche extracts of 250 mesh are obtained after being concentrated to dryness.
Step 2: adding sucrose fatty ester and xanthans into safflower seed oil, it is stored at room temperature, is removed not after grinding uniformly
Molten thing, obtain suspension base oil；
Step 3: the saline cistanche extraction of vitamin E, the OPC of 250 mesh and 250 mesh is added into the suspension base oil
Thing, it is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, high-pressure homogeneous place is carried out to the thick suspended oil
Reason；Homogenization pressure is 18Mpa, homogenizing time 22min；Degassing pressure is less than -0.10MPa, and degassing temperature is 97 DEG C, during degassing
Between be 2 hours；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
S1, according to glycerine, gelatin, mint juice and water mass ratio be 0.3:1:0.4:0.7 relation also known as takes bright
Glue, glycerine, mint juice and water, and weigh 0.3% curcumin of gelatin, glycerine, mint juice and water gross weight；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin solution,
0.8~1.2h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and 60
Insulation standing is carried out at DEG C, removes the foam of floating, capsule capsule shell fluid is obtained after filtering；
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, after being well mixed
Rolling molding ball, sizing, washing and drying are carried out, obtains saline cistanche capsule.
After rolling is molded ball, the pill-rolling 6h that dried at 25 DEG C obtains capsule to shape；Washed away with ethanol in pill wiping machine is washed
Capsule surface oil reservoir, and dry up the washing lotion of capsule surface；By the capsule after washing in being dried up 4 hours in net machine, saline cistanche is obtained
Capsule.
Embodiment 4：
The invention provides a kind of saline cistanche capsule, by capsule softgel shell and the content group being wrapped in the capsule softgel shell
Into the parts by weight of each component in content are：22 parts of cistanche extracts, 170 parts of safflower seed oil, 12 parts of OPC,
0.1 part of vitamin E2 part, 0.01 part of sucrose fatty ester and xanthans；
Capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water, wherein, glycerine, gelatin, mint juice and water
Mass ratio be 0.3:1:0.3:0.8, the quality of curcumin is the 0.3% of glycerine, gelatin, mint juice and water gross weight.
The invention also discloses a kind of preparation method of saline cistanche capsule, comprise the following steps：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 200 mesh；
Extraction：50~70v% ethanol solutions of 2~4 times of weight are added into the saline cistanche coarse powder of 200 mesh, are heated to 70
DEG C keep 2~4h, filter to obtain filter residue and filtrate, filter residue washed using 50~70v% ethanol solutions, merge cleaning solution and
Filtrate, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, reclaims ethanol, the cistanche extracts of 200 mesh are obtained after being concentrated to dryness.
Step 2: adding sucrose fatty ester and xanthans into safflower seed oil, it is stored at room temperature, is removed not after grinding uniformly
Molten thing, obtain suspension base oil；
Step 3: the saline cistanche extraction of vitamin E, the OPC of 250 mesh and 200 mesh is added into the suspension base oil
Thing, it is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, high-pressure homogeneous place is carried out to the thick suspended oil
Reason；Homogenization pressure is 18Mpa, homogenizing time 22min；Degassing pressure is less than -0.10MPa, and degassing temperature is 97 DEG C, during degassing
Between be 2 hours；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
S1, according to glycerine, gelatin, mint juice and water mass ratio be 0.3:1:0.3:0.8 relation also known as takes bright
Glue, glycerine, mint juice and water, and weigh 0.3% curcumin of gelatin, glycerine, mint juice and water gross weight；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin solution,
0.8~1.2h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and 60
Insulation standing is carried out at DEG C, removes the foam of floating, capsule capsule shell fluid is obtained after filtering.
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, after being well mixed
Rolling molding ball, sizing, washing and drying are carried out, obtains saline cistanche capsule.
After rolling is molded ball, the pill-rolling 6h that dried at 25 DEG C obtains capsule to shape；Washed away with ethanol in pill wiping machine is washed
Capsule surface oil reservoir, and dry up the washing lotion of capsule surface；By the capsule after washing in being dried up 4 hours in net machine, saline cistanche is obtained
Capsule.
Embodiment 5：
The invention provides a kind of saline cistanche capsule, by capsule softgel shell and the content group being wrapped in the capsule softgel shell
Into the parts by weight of each component in content are：18 parts of cistanche extracts, 150 parts of safflower seed oil, 15 parts of OPC,
0.02 part of vitamin E2 part, 0.1 part of sucrose fatty ester and xanthans；
Capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water, wherein, glycerine, gelatin, mint juice and water
Mass ratio be 0.3:1:0.3:0.6, the quality of curcumin is the 0.3% of glycerine, gelatin, mint juice and water gross weight.
The invention also discloses a kind of preparation method of saline cistanche capsule, comprise the following steps：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 200 mesh；
Extraction：50~70v% ethanol solutions of 3 times of weight are added into the saline cistanche coarse powder of 200 mesh, are heated to 70 DEG C of guarantors
2~4h is held, filter residue and filtrate is filtered to obtain, filter residue is washed using 50~70v% ethanol solutions, merges cleaning solution and filter
Liquid, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, reclaims ethanol, the cistanche extracts of 300 mesh are obtained after being concentrated to dryness.
Step 2: adding sucrose fatty ester and xanthans into safflower seed oil, it is stored at room temperature, is removed not after grinding uniformly
Molten thing, obtain suspension base oil；
Step 3: the saline cistanche extraction of vitamin E, the OPC of 300 mesh and 300 mesh is added into the suspension base oil
Thing, it is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, high-pressure homogeneous place is carried out to the thick suspended oil
Reason；Homogenization pressure is 18Mpa, homogenizing time 22min；Degassing pressure is less than -0.10MPa, and degassing temperature is 97 DEG C, during degassing
Between be 2 hours；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
S1, according to glycerine, gelatin, mint juice and water mass ratio be 0.3:1:0.3:0.6 relation also known as takes bright
Glue, glycerine, mint juice and water, and weigh 0.3% curcumin of gelatin, glycerine, mint juice and water gross weight；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin solution,
0.8~1.2h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and 60
Insulation standing is carried out at DEG C, removes the foam of floating, capsule capsule shell fluid is obtained after filtering.
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, after being well mixed
Rolling molding ball, sizing, washing and drying are carried out, obtains saline cistanche capsule.Rolling be molded ball after, at 25 DEG C dry pill-rolling 6h with
Sizing, obtains capsule；Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；Will washing
Capsule afterwards obtains saline cistanche capsule in being dried up 4 hours in net machine.
Performance test is carried out to saline cistanche capsule prepared by embodiment 1~5, shows the matter of sucrose fatty ester and xanthans
Amount can ensure that the stabilization time of content more than 100 hours, meets the needs of capsule makes stabilization time, improves saline cistanche
The stability of capsule.And clinical application effect is good, modern society is met because air, food security and operating pressure are made
Into sub-health population get well the demand of constitution.Mint juice is cleverly added in capsule softgel shell simultaneously, improves meat
The mouthfeel of desert cistanche capsule, and there is clearing and salubrious sensation, avoiding the peculiar smell of content influences the oral result of capsule.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art
Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, it is of the invention and unlimited
In specific details.
Claims (10)
1. a kind of saline cistanche capsule, it is made up of capsule softgel shell and the content being wrapped in the capsule softgel shell, it is characterised in that
The content includes cistanche extracts, safflower seed oil, OPC, vitamin E, the first suspending agent and the second suspending
Agent；The capsule softgel shell includes glycerine, gelatin, curcumin, mint juice and water.
2. a kind of saline cistanche capsule according to claim 1, it is characterised in that the content includes following parts by weight
Component：
15~25 parts of cistanche extracts, 100~200 parts of safflower seed oil, 10~20 parts of OPC, vitamin E2~6 part, the
One 0.01~0.8 part of suspending agent, the second 0.01~0.5 part of suspending agent.
3. a kind of saline cistanche capsule according to claim 2, it is characterised in that the content includes following parts by weight
Component：
16~22 parts of cistanche extracts, 100~170 parts of safflower seed oil, 12~18 parts of OPC, vitamin E2~4 part,
One 0.01~0.6 part of suspending agent, the second 0.01~0.1 part of suspending agent.
4. a kind of saline cistanche capsule according to claim 3, it is characterised in that the content includes following parts by weight
Component：
18 parts of cistanche extracts, 150 parts of safflower seed oil, 15 parts of OPC, vitamin E2 part, 0.1 part of the first suspending agent, the
Two 0.02 part of suspending agents.
5. a kind of saline cistanche capsule according to claim 1, it is characterised in that first suspending agent is sucrose-fatty
Ester, second suspending agent are xanthans.
6. a kind of saline cistanche capsule according to claim 1, it is characterised in that glycerine in the capsule softgel shell, gelatin, thin
The mass ratio of lotus juice and water is 0.2~0.4/1/0.2~0.4/0.6~0.8, the quality of the curcumin is glycerine, gelatin,
The 0.3% of mint juice and water gross weight.
A kind of 7. method for preparing the saline cistanche capsule according to any one of claim 1~6, it is characterised in that including with
Lower step：
Step 1: using saline cistanche as raw material, extracted from saline cistanche and prepare granular cistanche extracts；
Step 2: adding the first suspending agent and the second suspending agent into safflower seed oil, it is stored at room temperature, removes insoluble after grinding uniformly
Thing, obtain suspension base oil；
Step 3: vitamin E, granular OPC and the extraction of granular saline cistanche are added into the suspension base oil
Thing, it is stored at room temperature after grinding uniformly, and thick suspended oil is obtained after removing insoluble matter, high-pressure homogeneous place is carried out to the thick suspended oil
Reason；
Step 4: using glycerine, gelatin, curcumin, mint juice and water as raw material, capsule capsule shell fluid is prepared；
Step 5: the thick suspended oil after the capsule capsule shell fluid and homogenization is placed in incubator, carried out after well mixed
Rolling molding ball, sizing, washing and drying, obtain saline cistanche capsule.
A kind of 8. preparation method of saline cistanche capsule according to claim 7, it is characterised in that in the step 1, institute
The preparation process for stating granular cistanche extracts is：
Pretreatment：Dry saline cistanche is crushed using pulverizer, obtains the saline cistanche coarse powder of 100~200 mesh；
Extraction：50~70v% ethanol solutions of 2~4 times of weight, heating are added into the saline cistanche coarse powder of 100~200 mesh
To 60~80 DEG C of 2~4h of holding, filter residue and filtrate are filtered to obtain, filter residue is washed using 50~70v% ethanol solutions, is merged
Cleaning solution and filtrate, obtain ethanol extract；
Purifying：The filtrate is filtered using microfiltration membranes, milipore filter and nano filter membrane successively, obtains permeate；
Concentration：Permeate is filtered, ethanol is reclaimed, graininess cistanche extracts is obtained after being concentrated to dryness.
A kind of 9. preparation method of saline cistanche capsule according to claim 7, it is characterised in that in the step 4, institute
The preparation process for stating capsule capsule shell fluid is：
S1, the relation according to the mass ratio of glycerine, gelatin, mint juice and water for 0.2~0.4/1/0.2~0.4/0.6~0.8
Glycerine, gelatin, mint juice and water are weighed respectively, and weigh 0.3% curcumin of gelatin, glycerine, mint juice and water gross weight；
S2, gelatin is placed in water and soaked, gelatin is fully swelled, obtain gelatin solution；
S3, it is placed in after mint juice is mixed with glycerine in glue pot, and is heated to 70 DEG C, then add the gelatin solution, is stirred
0.8~1.2h is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and at 60 DEG C
Insulation standing is carried out, removes the foam of floating, capsule capsule shell fluid is obtained after filtering.
A kind of 10. preparation method of saline cistanche capsule according to claim 7, it is characterised in that in the step 5, institute
Stating sizing, washing and drying process is specially：
After rolling is molded ball, the pill-rolling 6h that dried at 25 DEG C obtains capsule to shape；
Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；
By the capsule after washing in being dried up 4 hours in net machine, saline cistanche capsule is obtained.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908399A (en) * | 2012-11-12 | 2013-02-06 | 孟令刚 | A composition containing desert cistanche or cynomorium songaricum or medlar, lecithin and vitamin E |
| CN106176868A (en) * | 2016-09-27 | 2016-12-07 | 乌鲁木齐上善元生物科技有限公司 | A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof |
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908399A (en) * | 2012-11-12 | 2013-02-06 | 孟令刚 | A composition containing desert cistanche or cynomorium songaricum or medlar, lecithin and vitamin E |
| CN106176868A (en) * | 2016-09-27 | 2016-12-07 | 乌鲁木齐上善元生物科技有限公司 | A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof |
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Application publication date: 20171201 |