CN107823300A - A kind of fragrant even capsule - Google Patents
A kind of fragrant even capsule Download PDFInfo
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- CN107823300A CN107823300A CN201711095245.7A CN201711095245A CN107823300A CN 107823300 A CN107823300 A CN 107823300A CN 201711095245 A CN201711095245 A CN 201711095245A CN 107823300 A CN107823300 A CN 107823300A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
A kind of fragrant even capsule, belongs to technical field of traditional Chinese medicine preparation, is prepared by the coptis and the banksia rose and auxiliary material, and the coptis is cornel coptis, and cornel coptis is processed by the even fruit of medicinal cornel, and even for the fruit of medicinal cornel by Chinese goldthread processed, accessory package includes chestnut starch；Its advantage is that evodia rutaecarpa can be eliminated into the toxicity in evodia rutaecarpa into the fruit of medicinal cornel is connected with Chinese goldthread processed on a small quantity first, and the coptis is processed into cornel coptis with the even fruit of medicinal cornel, the cold of cornel coptis can be made to subtract greatly；Its alcohol extracting Coptisextract is nontoxic and cold weaker；Banksia rose progress water extraction is concentrated to give costus resinoid powder and inulol, makes full use of its active ingredient；Chinese chestnut is warm-natured, can further cut down the cold of the coptis；By chestnut starch and extract powder with ethanol solution mix it is wet after be blended into talcum powder, the disintegration rate and dissolution rate of medicinal powder can be improved；The drug effect for improving fragrant even capsule can be generally cooperateed with, promotes absorption of the user to active ingredient；Effectively improve assimilation effect of the medicine in patient's body.
Description
Technical field
The present invention relates to a kind of technical field of traditional Chinese medicine preparation, and in particular to a kind of fragrant even capsule.
Background technology
Even capsule is formed perfume by the coptis, the taste Chinese prescription of the banksia rose two, is by version in 2005《Chinese Pharmacopoeia（One）》Record
Xianglian Wan change the capsule that forms through formulation, there is the effect of clearing away heat and eliminating dampeness, promoting qi circulation and relieving pain, cure mainly in damp-heat dysentery after urgency
Weight, stomachache diarrhea, bacillary dysentery, enteritis, also have the effect of certain to peptic ulcer, superficial gastritis.
In the prior art, fragrant even capsule directly uses cornel coptis in the preparation, and the purpose is to disappeared with the big heat of evodia rutaecarpa
Subtract the extremely cold of the coptis, still, evodia rutaecarpa is slightly poisonous medicine, and patient also has side effect after taking, to a certain extent
The effect of have impact on medicine.
In addition, existing fragrant even capsule can only be used as adhesive and fill out in the preparation using cornstarch as auxiliary material
Fill agent use, it is impossible to produce more preferable effect.
The content of the invention
The purpose of the present invention is provided a kind of combined using specific process for above-mentioned technical problem and special procures auxiliary material preparation
Perfume connects capsule, to cut down side effects of pharmaceutical drugs and accelerate disintegration and dissolution rate, on the whole the effect of collaboration raising medicine.
In order to solve the above technical problems, the technical solution adopted in the present invention is a kind of fragrant even capsule, by the coptis and the banksia rose
And auxiliary material is prepared, it is characterised in that the coptis is cornel coptis, the cornel coptis by even the fruit of medicinal cornel process, it is described even the fruit of medicinal cornel by
It is Chinese goldthread processed.
The preparation method of the even fruit of medicinal cornel is to take 8 parts of the coptis according to parts by weight, is wrapped up with gauze bag, it is pure to be put into 80-320 parts
Change and decocted in water, kept for micro-boiling 30-90 minutes after boiling, then cool down, add evodia rutaecarpa 16-160 parts, decocted, kept micro-
10-50 minutes are boiled, the coptis is then pulled out and is discarded, pull evodia rutaecarpa out, then decoction liquor is filtered, slagging-off takes filtrate, then will
Evodia rutaecarpa is put into filtrate, stews to moisten to filtrate and exhausts, then dries, and until the weight of evodia rutaecarpa is returned to original weight amount, obtains
The even fruit of medicinal cornel.
The preparation method of the cornel coptis is to take 80 parts of the fruit of medicinal cornel of company to be put into 80-320 part purified waters according to parts by weight and decoct
Boil, kept for micro-boiling 30-90 minutes after boiling, decoction liquor is taken into filtrate with the filtration of 100 mesh, takes coptis 80-320 parts to put into filtrate
In, stew to moisten to filtrate and exhaust, then dry, until the weight of the coptis is returned to original weight amount, obtain cornel coptis.
Further, the accessory package includes chestnut starch.
A kind of fragrant even capsule, it is characterised in that be prepared by the bulk drug and auxiliary material of following parts by weight：Wherein bulk drug
It is：1680 parts of the coptis, 800 parts of evodia rutaecarpa, 400 parts of the banksia rose, auxiliary material are：5 parts of chestnut starch 123-129 parts, talcum powder.
Its preparation method is.
(1) the company of the preparation fruit of medicinal cornel, 80 parts of the coptis is taken, is wrapped up with gauze bag, be put into 1600 parts of purified waters and decoct, protected after boiling
Micro-boiling 50-70 minutes are held, are then cooled down, add 800 parts of evodia rutaecarpa, are decocted, is kept for micro-boiling 25-35 minutes, then pulls Huang out
Connect and be discarded, pull evodia rutaecarpa out, then decoction liquor is filtered, slagging-off takes filtrate, then evodia rutaecarpa is put into filtrate, stews to moisten
Exhaust, then dry, until the weight of evodia rutaecarpa is returned to original weight amount, 800 parts of the company of the obtaining fruit of medicinal cornel to filtrate.
(2) cornel coptis is prepared, and 800 parts of the company of the taking fruit of medicinal cornel is put into 1600 parts of purified waters and decocted, and micro-boiling 50-70 is kept after boiling
Minute, decoction liquor is taken into filtrate with the filtration of 100 mesh, takes 1600 parts of the coptis to put into filtrate, stews to moisten to filtrate and exhaust, Ran Hougan
It is dry, until the weight of the coptis is returned to original weight amount, obtain 1600 parts of cornel coptis.
(3) coptis alcohol extracting immersion cream is prepared：Cornel coptis is put into extractor for 1600 parts, for the first time 9600 weights of extraction
70% ethanol solution of part is measured, cold soaking is after 4 hours, the refluxing extraction 2 hours in the case where temperature is 75~80 DEG C of environment；Second of extraction
With 70% ethanol solution of 6400 parts by weight, the refluxing extraction 1 hour in the case where temperature is 75~80 DEG C of environment, third time extraction is used
The ethanol solution of 4800 parts by weight 70%, the refluxing extraction 1 hour in the case where temperature is 75~80 DEG C of environment；Extract solution three times is collected to merge
Through 100 mesh screens, extract solution is pumped into the dual-purpose dual-effect concentrator of water alcohol, is 60~80 DEG C in temperature, vacuum is -0.04
In the environment of~-0.08Mpa, filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, is then transferred to scraper plate concentration
Device, it is 1.20~1.30 to continue to be concentrated into relative density in the environment of being 60~70 DEG C in temperature, obtains coptis alcohol extracting immersion cream.
(4) banksia rose water extraction immersion cream is prepared：The banksia rose is put into extractor for 400 parts, adds 4000 parts by weight purified waters, is soaked
Bubble 1 hour, is then decocted, and after decoction boiling, is adjusted and is made steam pressure holding≤0.1Mpa, and pressure inside the tank≤
0.1Mpa, decoction is set to keep micro-boiling 4 hours；Then extract solution is filtered through 100 mesh, removes slag and take liquid, at the same collect distillate in
48 hours are stood in separator, inulol is isolated, it is standby to obtain inulol；Then filtered fluid is pumped into economic benefits and social benefits outer circulation concentration
Concentrated in device, keep an effect temperature in 60~80 DEG C, vacuum in -0.02~-0.06Mpa；Two effect temperature are 60~80
DEG C, vacuum -0.04~-0.08 Mpa ambient condition；Filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15,
Be transferred to scraper concentrator while hot, continue in the environment of being 60~70 DEG C in temperature concentration densities to relative density be 1.20~
1.30, obtain banksia rose water extraction immersion cream.
(5) extract powder is prepared：Banksia rose water extraction immersion cream after concentration and coptis water extraction immersion cream are respectively charged into basin
It is dried, drying temperature is 60~70 DEG C, and vacuum is -0.07~-0.08Mpa, stops drying during dry extract moisture≤5%,
Crushed respectively again, sieve 80 mesh, remixes and mixes thoroughly, obtains banksia rose Coptisextract.
(6) take chestnut starch 123-129 parts and banksia rose Coptisextract to be mixed together and mix thoroughly, then added according to parts by weight
Concentration is 50% 50 parts of ethanol solution, carries out mixing and mixes thoroughly, then adds 5 parts of talcum powder, carries out mixing granulation, will make
The particle gone out is dried at a temperature of 65-75 DEG C, until granule moisture level be less than 5.0%, then by inulol spray be added to
On particle, 18 mesh sieves are crossed, obtain fragrant even powder, it is then encapsulated, obtain fragrant even capsule.
The beneficial effects of the invention are as follows with a small amount of Chinese goldthread processed into the even fruit of medicinal cornel, can effectively eliminate evodia rutaecarpa first by evodia rutaecarpa
In mild toxicity toxicity, then by the coptis with even the fruit of medicinal cornel be processed into cornel coptis, the cold of cornel coptis can be made to subtract greatly；Then by cornel coptis
Carry out alcohol extracting and be concentrated to give Coptisextract, the Coptisextract so obtained is nontoxic and cold weaker；The banksia rose is subjected to water extraction
Costus resinoid powder and inulol are concentrated to give, makes full use of its active ingredient；Again by the use of chestnut starch and talcum powder as auxiliary material, no
It is only capable of accessing the due effect of auxiliary material institute, because Chinese chestnut is warm-natured, can further cuts down the cold of the coptis；By chestnut starch and
Extract powder with ethanol solution mix it is wet after be blended into talcum powder, the disintegration rate after medicinal powder is taken and dissolution rate can be improved；Its
Resultant effect can not only cooperate with the drug effect for improving fragrant even capsule, moreover it is possible to promote absorption of the user to active ingredient；In entirety
On can effectively improve assimilation effect of the medicine in patient's body.
Embodiment
With reference to embodiment, the invention will be further described, and following examples are intended to illustrate invention rather than to this
The further restriction of invention, should not be limited the scope of the invention with this.
Embodiment 1：Prepare fragrant even capsule.
Take coptis 1680g, evodia rutaecarpa 800g, banksia rose 400g, chestnut starch 123g, talcum powder 5g.
In accordance with the following steps prepared by method.
(1) the company of the preparation fruit of medicinal cornel, coptis 80g is taken, is wrapped up with gauze bag, be put into 1600g purified waters and decoct, kept after boiling
Micro-boiling 50 minutes, is then cooled down, and adds evodia rutaecarpa 800g, is decocted, and keeps micro-boiling 25 minutes, is then pulled the coptis out and is discarded not
With, to pull evodia rutaecarpa out, decoction liquor is filtered, slagging-off takes filtrate, then evodia rutaecarpa is put into filtrate, stews to moisten to filtrate and exhausts,
Then dry, until the weight of evodia rutaecarpa is 800g, that is, the company of obtaining fruit of medicinal cornel 800g.
(2) cornel coptis is prepared, the company of taking fruit of medicinal cornel 800g, which is put into 1600g purified waters, to be decocted, and micro-boiling is kept 50 minutes after boiling,
Decoction liquor is taken into filtrate with the filtration of 100 mesh, takes coptis 1600g to put into filtrate, stews to moisten to filtrate and exhaust, then dry, directly
Weight to the coptis is 1600g, that is, obtains cornel coptis 1600g.
(3) coptis alcohol extracting immersion cream is prepared：Cornel coptis 1600g is put into extractor, extraction for the first time is with 9600g's
The ethanol solution that concentration is 70% carries out cold soaking, and cold soaking is after 4 hours, the refluxing extraction 2 hours in the case where temperature is 75-76 DEG C of environment；The
Second extraction 70% ethanol solution of 6400 parts by weight, in the case where temperature is 75-76 DEG C of environment, refluxing extraction 1 hour, is carried for the third time
The ethanol solution of 4800 parts by weight 70% is taken, the refluxing extraction 1 hour in the case where temperature is 75-76 DEG C of environment；Extract solution three times is collected to close
And through 100 mesh screens, extract solution is pumped into the dual-purpose dual-effect concentrator of water alcohol, be 60-65 DEG C in temperature, vacuum for-
In the environment of 0.04~-0.05Mpa, filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, it is dense to be then transferred to scraper plate
Contracting device, it is 1.20~1.30 to continue to be concentrated into relative density in the environment of being 60-63 DEG C in temperature, obtains coptis alcohol extracting immersion
Cream.
(4) banksia rose water extraction immersion cream is prepared：Banksia rose 400g is put into extractor, adds 4000g purified waters, it is small to soak 1
When, then decocted, after decoction boiling, adjust and make steam pressure holding≤0.1Mpa, pressure inside the tank≤0.1Mpa, make
Decoction keeps micro-boiling 4 hours；Then extract solution is filtered through 100 mesh, removes slag and take liquid, while it is quiet in separator to collect distillate
Put 48 hours, isolate inulol, it is standby to obtain inulol 8.3g；Then filtered fluid is pumped into economic benefits and social benefits outer circulation inspissator
Row concentration, keep an effect temperature in 60-65 DEG C, vacuum -0.02~-0.03, Mpa；Two effect temperature are in 60-65 DEG C, vacuum
Spend the ambient condition in -0.04~-0.05Mpa；Filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, then while hot
Scraper concentrator is transferred to, it is 1.20~1.30 to continue concentration densities to relative density in the environment of being 60-63 DEG C in temperature, is obtained
To banksia rose water extraction immersion cream.
(5) extract powder is prepared：Banksia rose water extraction immersion cream after concentration and coptis water extraction immersion cream are respectively charged into basin
It is dried, drying temperature is 60-63 DEG C, and vacuum is -0.07~-0.08Mpa, stops drying during dry extract moisture≤5%,
Crushed respectively again, sieve 80 mesh, remixes and mixes thoroughly, obtains banksia rose Coptisextract 372.3g.
(6) take chestnut starch 123g and banksia rose Coptisextract to be mixed together and mix thoroughly, then add the ethanol that concentration is 50%
Solution 50g, continue mixing and mix thoroughly, add talcum powder 5g, mixing granulation is carried out, by the particle made in 65-68
Be dried at a temperature of DEG C, until granule moisture level be less than 5.0%, then by inulol spray be added on particle, cross 18 mesh
Sieve, fragrant even powder is obtained, it is then encapsulated, obtain fragrant even capsule 1000, every dress 0.5g.
Embodiment 2：Prepare fragrant even capsule.
Take coptis 1680g, evodia rutaecarpa 800g, banksia rose 400g, chestnut starch 126g, talcum powder 5g.
In accordance with the following steps prepared by method.
(1) the company of the preparation fruit of medicinal cornel, coptis 80g is taken, is wrapped up with gauze bag, be put into 1600g purified waters and decoct, kept after boiling
Micro-boiling 60 minutes, is then cooled down, and adds evodia rutaecarpa 800g, is decocted, and keeps micro-boiling 30 minutes, is then pulled the coptis out and is discarded not
With, to pull evodia rutaecarpa out, decoction liquor is filtered, slagging-off takes filtrate, then evodia rutaecarpa is put into filtrate, stews to moisten to filtrate and exhausts,
Then dry, until the weight of evodia rutaecarpa is 800g, that is, the company of obtaining fruit of medicinal cornel 800g.
(2) cornel coptis is prepared, the company of taking fruit of medicinal cornel 800g, which is put into 1600g purified waters, to be decocted, and micro-boiling is kept 60 minutes after boiling,
Decoction liquor is taken into filtrate with the filtration of 100 mesh, takes coptis 1600g to put into filtrate, stews to moisten to filtrate and exhaust, then dry, directly
Weight to the coptis is 1600g, that is, obtains cornel coptis 1600g.
(3) coptis alcohol extracting immersion cream is prepared：Cornel coptis 1600g is put into extractor, extraction for the first time is with 9600g's
The ethanol solution that concentration is 70% carries out cold soaking, and cold soaking is after 4 hours, the refluxing extraction 2 hours in the case where temperature is 76-79 DEG C of environment；The
Second extraction 70% ethanol solution of 6400 parts by weight, in the case where temperature is 76-79 DEG C of environment, refluxing extraction 1 hour, is carried for the third time
The ethanol solution of 4800 parts by weight 70% is taken, the refluxing extraction 1 hour in the case where temperature is 76-79 DEG C of environment；Extract solution three times is collected to close
And through 100 mesh screens, extract solution is pumped into the dual-purpose dual-effect concentrator of water alcohol, be 65-75 DEG C in temperature, vacuum for-
In the environment of 0.05~-0.07Mpa, filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, it is dense to be then transferred to scraper plate
Contracting device, it is 1.20~1.30 to continue to be concentrated into relative density in the environment of being 63-67 DEG C in temperature, obtains coptis alcohol extracting immersion
Cream.
(4) banksia rose water extraction immersion cream is prepared：Banksia rose 400g is put into extractor, adds 4000g purified waters, it is small to soak 1
When, then decocted, after decoction boiling, adjust and make steam pressure holding≤0.1Mpa, pressure inside the tank≤0.1Mpa, make
Decoction keeps micro-boiling 4 hours；Then extract solution is filtered through 100 mesh, removes slag and take liquid, while it is quiet in separator to collect distillate
Put 48 hours, isolate inulol, it is standby to obtain inulol 8.3g；Then filtered fluid is pumped into economic benefits and social benefits outer circulation inspissator
Row concentration, keep an effect temperature in 65-75 DEG C, vacuum -0.03~-0.05, Mpa；Two effect temperature are in 65-75 DEG C, vacuum
Spend the ambient condition in -0.05~-0.07Mpa；Filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, then while hot
Scraper concentrator is transferred to, it is 1.20~1.30 to continue concentration densities to relative density in the environment of being 63-67 DEG C in temperature, is obtained
To banksia rose water extraction immersion cream.
(5) extract powder is prepared：Banksia rose water extraction immersion cream after concentration and coptis water extraction immersion cream are respectively charged into basin
It is dried, drying temperature is 63-67 DEG C, and vacuum is -0.07~-0.08Mpa, stops drying during dry extract moisture≤5%,
Crushed respectively again, sieve 80 mesh, remixes and mixes thoroughly, obtains banksia rose Coptisextract 369.7g.
(6) take chestnut starch 126g and banksia rose Coptisextract to be mixed together and mix thoroughly, then add the ethanol that concentration is 50%
Solution 50g, continue mixing and mix thoroughly, add talcum powder 5g, mixing granulation is carried out, by the particle made in 68-72
Be dried at a temperature of DEG C, until granule moisture level be less than 5.0%, then by inulol spray be added on particle, cross 18 mesh
Sieve, fragrant even powder is obtained, it is then encapsulated, obtain fragrant even capsule 1000, every dress 0.5g.
Embodiment 3：Prepare fragrant even capsule.
Take coptis 1680g, evodia rutaecarpa 800g, banksia rose 400g, chestnut starch 129g, talcum powder 5g.
In accordance with the following steps prepared by method.
(1) the company of the preparation fruit of medicinal cornel, coptis 80g is taken, is wrapped up with gauze bag, be put into 1600g purified waters and decoct, kept after boiling
Micro-boiling 70 minutes, is then cooled down, and adds evodia rutaecarpa 800g, is decocted, and keeps micro-boiling 35 minutes, is then pulled the coptis out and is discarded not
With, to pull evodia rutaecarpa out, decoction liquor is filtered, slagging-off takes filtrate, then evodia rutaecarpa is put into filtrate, stews to moisten to filtrate and exhausts,
Then dry, until the weight of evodia rutaecarpa is 800g, that is, the company of obtaining fruit of medicinal cornel 800g.
(2) cornel coptis is prepared, the company of taking fruit of medicinal cornel 800g, which is put into 1600g purified waters, to be decocted, and micro-boiling is kept 70 minutes after boiling,
Decoction liquor is taken into filtrate with the filtration of 100 mesh, takes coptis 1600g to put into filtrate, stews to moisten to filtrate and exhaust, then dry, directly
Weight to the coptis is 1600g, that is, obtains cornel coptis 1600g.
(3) coptis alcohol extracting immersion cream is prepared：Cornel coptis 1600g is put into extractor, extraction for the first time is with 9600g's
The ethanol solution that concentration is 70% carries out cold soaking, and cold soaking is after 4 hours, the refluxing extraction 2 hours in the case where temperature is 79-80 DEG C of environment；The
Second extraction 70% ethanol solution of 6400 parts by weight, in the case where temperature is 79-80 DEG C of environment, refluxing extraction 1 hour, is carried for the third time
The ethanol solution of 4800 parts by weight 70% is taken, the refluxing extraction 1 hour in the case where temperature is 79-80 DEG C of environment；Extract solution three times is collected to close
And through 100 mesh screens, extract solution is pumped into the dual-purpose dual-effect concentrator of water alcohol, be 75-80 DEG C in temperature, vacuum for-
In the environment of 0.07~-0.08Mpa, filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, it is dense to be then transferred to scraper plate
Contracting device, it is 1.20~1.30 to continue to be concentrated into relative density in the environment of being 67-70 DEG C in temperature, obtains coptis alcohol extracting immersion
Cream.
(4) banksia rose water extraction immersion cream is prepared：Banksia rose 400g is put into extractor, adds 4000g purified waters, it is small to soak 1
When, then decocted, after decoction boiling, adjust and make steam pressure holding≤0.1Mpa, pressure inside the tank≤0.1Mpa, make
Decoction keeps micro-boiling 4 hours；Then extract solution is filtered through 100 mesh, removes slag and take liquid, while it is quiet in separator to collect distillate
Put 48 hours, isolate inulol, it is standby to obtain inulol 8.3g；Then filtered fluid is pumped into economic benefits and social benefits outer circulation inspissator
Row concentration, keep an effect temperature in 75-80 DEG C, vacuum in -0.05~-0.06Mpa；Two effect temperature are in 75-80 DEG C, vacuum
In -0.07~-0.08Mpa ambient condition；Filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, then turned while hot
Scraper concentrator is moved to, it is 1.20~1.30 to continue concentration densities to relative density in the environment of being 67-70 DEG C in temperature, is obtained
Banksia rose water extraction immersion cream.
(5) extract powder is prepared：Banksia rose water extraction immersion cream after concentration and coptis water extraction immersion cream are respectively charged into basin
It is dried, drying temperature is 67-70 DEG C, and vacuum is -0.07~-0.08Mpa, stops drying during dry extract moisture≤5%,
Crushed respectively again, sieve 80 mesh, remixes and mixes thoroughly, obtains banksia rose Coptisextract 366.5g.
(6) take chestnut starch 129g and banksia rose Coptisextract to be mixed together and mix thoroughly, then add the ethanol that concentration is 50%
Solution 50g, continue mixing and mix thoroughly, add talcum powder 5g, carry out mixing granulation, by the particle made in 65-68,
Be dried at a temperature of 68-72,72-75 DEG C, until granule moisture level be less than 5.0%, then by inulol spray be added to particle
On, 18 mesh sieves are crossed, obtain fragrant even powder, it is then encapsulated, obtain fragrant even capsule 1000, every dress 0.5g.
The instructions of taking of this capsule is each 2-3 grains of adult, and 3 times a day, children are cut down according to the circumstance.
The test of pesticide effectiveness.
NIH mouse 120,20 ± 2g of average weight are taken, are randomly divided into three test groups and three control groups, every group 20
Only.Control group 1 does not have to any medicine, only gavages 5% charcoal end suspension 20ml/kg；Control group 2 does not take fragrant even powder, only takes
Charred RADIX ET RHIZOMA RHEI end suspension；Control group 3 takes the fragrant even capsule of Compendium of Materia Medica board of in the market purchase, and its every content 0.55g, it is said
Bright book instructions of taking is identical with this product；The product that test group 1,2,3 is produced with embodiment 1,2,3 respectively；In this experiment
Dose is the dry particl powder 2g/kg body weight in fragrant even capsule, and 20ml/kg body weight is dissolved into distilled water when gavaging.Examination
Equal fasting 24 hours before testing, free water, after distinguishing gastric infusion 20min to control group 3, test group 1,2,3, to control group 1
5% charcoal end suspension 20ml/kg is gavaged, charred RADIX ET RHIZOMA RHEI end suspension 20ml/kg is gavaged to control group 2,3, test group 1,2,3, is seen
Examine grain number and shape that melena in the time of melena and 4 hours occurs in each group.It the results are shown in Table 1.
The fragrant even capsule of table 1. is anti-diarrhea on NIH mouse to influence experimental observation statistical form.
Thus it is clear that take the fragrant even control group 3 of pharmaceutical capsules and test group 1,2,3 occur time of excretion melena much larger than pair
Control group 2 is much smaller than according to the quantity for organizing excretion melena in 2,4 hours, the shape of melena is also better than control group 2, it is demonstrated experimentally that clothes
Diarrhoea can be effectively treated with the fragrant even control group 3 of pharmaceutical capsules and test group 1,2,3, data are shown, product of the present invention
Drug effect is slightly better than the product of in the market purchase.
Toxicological study.
Acute toxicity test shows that the maximal tolerance dose that NIH mouse take medicine of the present invention is 395g/kg, equivalent to facing
13000 times of bed dosage (0.03g/kg), therefore, the Clinical practice dosage of this product is very safe.
Long term toxicity test：NIH mouse 100 are taken, are divided into test group and each 50 of control group, test group is produced with the present invention
Product gavage, 3 times a day, each taking the dry particl powder 1g/kg body weight in fragrant even capsule, it is dissolved into when gavaging with distilled water
20ml/kg body weight；Control group does not take any medicine, remaining activity and feeding situation all same, after three months, to every pathology
Histological indices are detected, and result of the test does not find that any toxicity, blood picture and kidney function indicator and control group are equal
No significant difference.
Disintegration time limited tests.
The like product bought on the products and marketing of the present embodiment 1,2,3 is subjected to contrast test, is divided into control group 1 and examination
Test group 1,2,3.Every group takes 3 capsule particles, and valve comes unglued softgel shell, pours out drug particles, it is respectively put into successively 60 DEG C, 50
DEG C, in 40 DEG C of each 100ml water, record from time for being disintegrated completely is put into, the results are shown in Table 2.
Table 2. disintegration time limited control test table.
It can be seen that according to the inventive method production fragrant even capsule product disintegration rate than like product that in the market is bought
Disintegration rate it is fast.
Claims (5)
1. a kind of fragrant even capsule, is prepared, it is characterised in that the coptis is cornel coptis, described by the coptis and the banksia rose and auxiliary material
Cornel coptis is processed by the even fruit of medicinal cornel, and the even fruit of medicinal cornel is by Chinese goldthread processed.
2. fragrant even capsule according to claim 1, it is characterised in that the preparation method of the even fruit of medicinal cornel is according to parts by weight
8 parts of the coptis is taken, is wrapped up with gauze bag, is put into 80-320 part purified waters and decocts, is kept for micro-boiling 30-120 minutes after boiling, then
Cooling, adds evodia rutaecarpa 16-160 parts, decocts, and is kept for micro-boiling 10-60 minutes, then pulls the coptis out and be discarded, pull out
Evodia rutaecarpa, then decoction liquor is filtered, slagging-off takes filtrate, then evodia rutaecarpa is put into filtrate, stews to moisten to filtrate and exhausts, Ran Hougan
It is dry, until the weight of evodia rutaecarpa is returned to original weight amount, the company of the obtaining fruit of medicinal cornel.
3. fragrant even capsule according to claim 2, it is characterised in that the preparation method of the cornel coptis is, according to parts by weight
80 parts of the company of the taking fruit of medicinal cornel is put into 80-320 part purified waters and decocted, and is kept for micro-boiling 30-120 minutes after boiling, by decoction liquor with 100 mesh
Filtration takes filtrate, takes coptis 80-320 parts to put into filtrate, stews to moisten to filtrate and exhausts, then dries, until the weight of the coptis
Original weight amount is returned to, obtains cornel coptis.
4. fragrant even capsule according to claim 3, it is characterised in that the accessory package includes chestnut starch.
5. fragrant even capsule according to claim 4, it is characterised in that by bulk drug and the auxiliary material preparation of following parts by weight
Into：Wherein bulk drug is：1680 parts of the coptis, 800 parts of evodia rutaecarpa, 400 parts of the banksia rose, auxiliary material are：Chestnut starch 123-129 parts, cunning
5 parts of stone flour；
Its preparation method is：
(1) the company of the preparation fruit of medicinal cornel, 80 parts of the coptis is taken, is wrapped up with gauze bag, be put into 1600 parts of purified waters and decoct, keep micro- after boiling
50-70 minutes are boiled, then cools down, adds 800 parts of evodia rutaecarpa, are decocted, is kept for micro-boiling 20-40 minutes, then pulls the coptis out simultaneously
It is discarded, pulls evodia rutaecarpa out, then decoction liquor is filtered, slagging-off takes filtrate, then evodia rutaecarpa is put into filtrate, stews to moisten to filter
Liquid exhausts, and then dries, until the weight of evodia rutaecarpa is returned to original weight amount, 800 parts of the company of the obtaining fruit of medicinal cornel；
(2) cornel coptis is prepared, 800 parts of the company of the taking fruit of medicinal cornel is put into 1600 parts of purified waters and decocted, and is kept for micro-boiling 0.5-2 hours after boiling,
Decoction liquor is taken into filtrate with the filtration of 100 mesh, takes 1600 parts of the coptis to put into filtrate, stews to moisten to filtrate and exhaust, then dry, directly
Weight to the coptis is returned to original weight amount, obtains 1600 parts of cornel coptis；
(3) coptis alcohol extracting immersion cream is prepared：Cornel coptis is put into extractor for 1600 parts, for the first time 9600 parts by weight of extraction
70% ethanol solution, cold soaking is after 4 hours, the refluxing extraction 2 hours in the case where temperature is 75~80 DEG C of environment；Second of extraction is used
70% ethanol solution of 6400 parts by weight, the refluxing extraction 1 hour in the case where temperature is 75~80 DEG C of environment, third time is extracted with 4800
The ethanol solution of parts by weight 70%, the refluxing extraction 1 hour in the case where temperature is 75~80 DEG C of environment；Extract solution three times is collected to merge through 100
Mesh screen, extract solution is pumped into the dual-purpose dual-effect concentrator of water alcohol, temperature be 60~80 DEG C, vacuum be -0.04~-
In the environment of 0.08Mpa, filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, is then transferred to scraper concentrator,
It is 1.20~1.30 that temperature continues to be concentrated into relative density in the environment of being 60~70 DEG C, obtains coptis alcohol extracting immersion cream；
(4) banksia rose water extraction immersion cream is prepared：The banksia rose is put into extractor for 400 parts, adds 4000 parts by weight purified waters, it is small to soak 1
When, then decocted, after decoction boiling, adjust and make steam pressure holding≤0.1Mpa, pressure inside the tank≤0.1Mpa, make
Decoction keeps micro-boiling 4 hours；Then extract solution is filtered through 100 mesh, removes slag and take liquid, while it is quiet in separator to collect distillate
Put 48 hours, isolate inulol, it is standby to obtain inulol；Then filtered fluid is pumped into economic benefits and social benefits outer circulation inspissator carry out it is dense
Contracting, keep an effect temperature in 60~80 DEG C, vacuum in -0.02~-0.06Mpa；Two effect temperature are in 60~80 DEG C, vacuum
In -0.04~-0.08 Mpa ambient condition；Filtrate is concentrated to the medicinal extract that relative density is 1.05-1.15, is transferred to while hot
Scraper concentrator, it is 1.20~1.30 to continue concentration densities to relative density in the environment of being 60~70 DEG C in temperature, obtains wood
Perfume carries immersion cream；
(5) extract powder is prepared：Banksia rose water extraction immersion cream after concentration and coptis water extraction immersion cream are respectively charged into basin and carried out
Dry, drying temperature is 60~70 DEG C, and vacuum is -0.07~-0.08Mpa, stops drying during dry extract moisture≤5%, then divide
Do not crushed, sieve 80 mesh, remixes and mixes thoroughly, obtains banksia rose Coptisextract；
(6) take chestnut starch 123-129 parts and banksia rose Coptisextract to be mixed together and mix thoroughly, then add concentration according to parts by weight
For 50% 50 parts of ethanol solution, carry out mixing and mix thoroughly, then add 5 parts of talcum powder, mixing granulation is carried out, by what is made
Particle is dried at a temperature of 65-75 DEG C, until granule moisture level be less than 5.0%, then by inulol spray be added to particle
On, 18 mesh sieves are crossed, obtain fragrant even powder, it is then encapsulated, obtain fragrant even capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111905017A (en) * | 2019-05-09 | 2020-11-10 | 西南大学 | Traditional Chinese medicine composition for resisting helicobacter pylori and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362245A (en) * | 2001-01-08 | 2002-08-07 | 杨孟君 | Nano medicine for Aucklandiae, coptidis and evodiae and its preparation |
| CN1823937A (en) * | 2006-01-12 | 2006-08-30 | 北京阜康仁生物制药科技有限公司 | Saussurea and coptis preparation and preparation method |
| CN105770108A (en) * | 2016-04-08 | 2016-07-20 | 江西樟树天齐堂中药饮片有限公司 | Evodia rutaecarpa processing technology |
-
2017
- 2017-11-09 CN CN201711095245.7A patent/CN107823300A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362245A (en) * | 2001-01-08 | 2002-08-07 | 杨孟君 | Nano medicine for Aucklandiae, coptidis and evodiae and its preparation |
| CN1823937A (en) * | 2006-01-12 | 2006-08-30 | 北京阜康仁生物制药科技有限公司 | Saussurea and coptis preparation and preparation method |
| CN105770108A (en) * | 2016-04-08 | 2016-07-20 | 江西樟树天齐堂中药饮片有限公司 | Evodia rutaecarpa processing technology |
Non-Patent Citations (5)
| Title |
|---|
| YOSHIMI SUGIMOTO ETC: "Developmental Changes in the Properties of Chestnut Starches", 《THE JAPANESE SOCIETY OF APPLIED GLYCOSCIENCE》 * |
| 刘畅等: "板栗淀粉结构和功能特性研究进展", 《中国粮油学报》 * |
| 叶定臣等: "《中药炮制学》", 31 March 1999, 中国中医药出版社 * |
| 王薇等: "香连胶囊的制备与质量标准研究", 《中国药业》 * |
| 陈秀瑗等: "《中药炮制技术》", 31 January 2017, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111905017A (en) * | 2019-05-09 | 2020-11-10 | 西南大学 | Traditional Chinese medicine composition for resisting helicobacter pylori and application thereof |
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Application publication date: 20180323 |