CN107753727A - A kind of composition of yin-nourishing - Google Patents
A kind of composition of yin-nourishing Download PDFInfo
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- CN107753727A CN107753727A CN201711063153.0A CN201711063153A CN107753727A CN 107753727 A CN107753727 A CN 107753727A CN 201711063153 A CN201711063153 A CN 201711063153A CN 107753727 A CN107753727 A CN 107753727A
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- China
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- composition
- lily
- yin
- gingko
- lotus seeds
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of composition of yin-nourishing, belong to health product technology field, belong to technical field of Chinese medicine, it is made up of the following raw material：Wheat, maize, barley, gingko, lotus seeds, lily.
Description
Technical field
The present invention relates to a kind of composition of yin-nourishing, belong to health product technology field, belong to technical field of Chinese medicine.
Background technology
Tcm constitution Theoretic Source About in《Interior warp》, the body and the spirit space formation of Constitution Theory in TCM thinks that constitution is specific body
The synthesis of quality and certain psychological quality, embody " unity of body and soul " thought of the traditional Chinese medical science.Wang Qi tcm constitutions rule of Nine-bag
Include 9 kinds of basic classes such as gentle matter, deficiency of vital energy matter, deficiency of yang matter, deficiency of Yin matter, deficiency of Yin matter, damp and hot matter, hemostasis matter, obstruction of the circulation of vital energy matter, special official report matter
Type, different somatotypes respectively have spy in body characteristicses, physiological characteristic, psychological characteristics, pathological reaction state, morbidity tendency etc.
Point；" three distinguish theoretical " --- distinguish body, the differentiation of disease, dialectical Diagnosis-treat Model etc..
Yin-deficiency constitution refers to when visceral dysfunction internal YIN-fluid being insufficient, deficiency of Yin Sheng Neire syndrome, normal table easily occur
Now become thin, hectically flushed cheeks, feverishness in palms and soles, hectic fever night sweat, dysphoria, dry, hair, xerosis cutis, tongue extra dry red wine, lack for body
Tongue, or even smooth no tongue, invade, the product of overfeeding temperate-dryness, over-anxiety, intemperance in sexual life, send out after prolonged illness because scorching heresy is outer more
Disease.Morbidity tendency：Be susceptible to suffer from consumptive disease, lose essence, be insomnia, the resistance to winter intolerant to the summer, intolerant to suffer from heatstroke, heat, dryness evil.Should with nourish yin-fluid, assistant
, should also be dialectical for the related internal organs deficiency of Yin using heat-clearing as the rules for the treatment of, the yin-fluid from nourishing the five internal organs, assistant are with the abnormal heat of clear the five internal organs respectively
Prescription, it is theoretical according to interdependence between yin and yang, add the product of a small amount of yang-tonifying.
Sedative is only used only for edgy in doctor trained in Western medicine, and toxic side effect is serious, it is impossible to long-term use of.
The people of yin-deficiency constitution is edgy, usually dysphoria, and traditional Chinese medicine thinks, this be it is fire excess from yin deficiency, fire disturb gods it
Therefore.It should especially follow《The Yellow Emperor's Canon of Internal Medicine》(referring to human body manner will for " tranquilized mind " (spirit is relaxed, without distracting thoughts), " keeping a sound mind "
Keep in interior, do not dissipate with outside) big method of reposing.To strengthen self-discipline usually, consciously form calm, calm custom.It is few
Participate in the recreational activities to stack up against.Avoid staying up late, worked under strenuous exercise and high temperature and heating summer.Stay up late and consume cloudy blood, the natural deficiency of Yin
Hyperactivity of fire.Deficiency of Yin Sheng Neire, therefore enriching yin should be noted that with antipyretic method with use, or enriching yin is with moisturizing with use.
The traditional Chinese medical science thinks：The more property of drugs for nourishing yin are soft and greasy, the easy impairment of the spleen sun of long term usage, easily cause the diseases such as anorexia, abdominal distension diarrhoea,
So plus the regulating qi-flowing for strengthening spleen treatment for relieving indigestion and constipation such as orange peel, Poria cocos, Chinese yam product, regulating qi-flowing for strengthening spleen, dehumidifying helps fortune, promotes to digest and assimilate, exploitation use
In the product of yin-deficiency constitution symptom be valuable.
The content of the invention
For the above mentioned problem of prior art, the present invention provides a kind of composition and its preparation method of yin-nourishing.
A kind of composition of yin-nourishing, it is made up of the following raw material：Gingko, lotus seeds, lily.
A kind of composition of yin-nourishing, it is made up of the following raw material：Wheat, maize, barley, gingko, lotus seeds, lily.
A kind of composition of yin-nourishing, it is made up of the following raw material：Gingko, lotus seeds, lily.
A kind of composition of yin-nourishing, it is made up of the following raw material：Wheat, maize, barley, gingko, lotus seeds, lily.
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Gingko 1-10, lotus seeds 1-20, lily 1-10.
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Gingko 10, lotus seeds 20, lily 10.
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 1-20, maize 1-20, barley 1-20,
Gingko 1-10, lotus seeds 1-20, lily 1-10.
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 20, maize 20, barley 20, gingko
10, lotus seeds 20, lily 10.
A kind of preparation method of the composition of yin-nourishing be it is following any one.
A kind of preparation method A-D of composition of the present invention
A kind of preparation method of the composition of yin-nourishing is：
Gingko, lotus seeds, lily, mix, crush, add 4-10 times to measure boiling boiling extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06-1.14；Concentrate centrifuge, take from
Heart liquid is standby；Centrifugate is spray-dried, and spray dryer EAT is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray
Mist is dried gained dry cream and crushed, and crosses 80 mesh, obtains gingko lotus seeds lily composition A.
A kind of preparation method of the composition of yin-nourishing is：
Wheat, maize, barley, gingko, lotus seeds, lily, mix, crush, add 4-10 times measure boiling boiling extraction 0.5-2 it is small
When, extract 1-3 times, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06-1.14；Concentrate
It is standby with centrifuge, extracting centrifugal liquid；Centrifugate is spray-dried, and spray dryer EAT is 180-205 DEG C, goes out wind-warm syndrome
Spend for 90-105 DEG C；Take spray drying gained dry cream to crush, cross 80 mesh, obtain gingko lotus seeds lily composition B.
A kind of preparation method of the composition of yin-nourishing is：
Wheat, maize, barley, mix, crush, add 4-10 times to measure boiling boiling extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and merging filtered fluid is standby, obtains wheat maize barley filtrate；
Gingko, lotus seeds, lily, mix, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours,
Extraction 1-3 times, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06-1.14；Concentrate with from
Scheming centrifuges, and extracting centrifugal liquid is standby；Centrifugate is spray-dried, and spray dryer EAT is 180-205 DEG C, and leaving air temp is
90-105℃；Take spray drying gained dry cream to crush, cross 80 mesh, obtain gingko lotus seeds lily composition C.
A kind of preparation method of the composition of yin-nourishing is：
Wheat, maize, barley, mix, crush, add 4-10 times to measure boiling boiling extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and merging filtered fluid is standby, obtains wheat maize barley filtrate；
Gingko, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06-1.14；Concentrate centrifuge, take from
Heart liquid is standby；Centrifugate is spray-dried, and spray dryer EAT is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray
Mist is dried gained dry cream and crushed, and crosses 80 mesh, obtains gingko composition；
Lotus seeds, mix, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours, extract 1-3 times,
Extract solution filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06-1.14；Concentrate centrifuge,
Extracting centrifugal liquid is standby；Centrifugate is spray-dried, and spray dryer EAT is 180-205 DEG C, and leaving air temp is 90-105 DEG C；
Take spray drying gained dry cream to crush, cross 80 mesh, obtain lotus seeds composition；
Lily, mix, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours, extract 1-3 times,
Extract solution filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06-1.14；Concentrate centrifuge,
Extracting centrifugal liquid is standby；Centrifugate is spray-dried, and spray dryer EAT is 180-205 DEG C, and leaving air temp is 90-105 DEG C；
Take spray drying gained dry cream to crush, cross 80 mesh, obtain lily composition；
Gingko composition, lotus seeds composition, lily composition, according to parts by weight (1-10)：(1-10)：(1-10) is mixed,
Obtain gingko lotus seeds lily composition D.
A kind of preparation method A2-D2 of composition of the present invention
A kind of preparation method of the composition of yin-nourishing is：
Gingko, lotus seeds, lily, mix, crush, add 4-10 times to measure boiling boiling extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and dries, obtains gingko lotus seeds lily composition A2.
A kind of preparation method of the composition of yin-nourishing is：
Wheat, maize, barley, gingko, lotus seeds, lily, mix, crush, add 4-10 times measure boiling boiling extraction 0.5-2 it is small
When, extract 1-3 times, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and dries, obtains gingko lotus seeds lily composition
B2。
A kind of preparation method of the composition of yin-nourishing is：
Wheat, maize, barley, mix, crush, add 4-10 times to measure boiling boiling extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and merging filtered fluid is standby, obtains wheat maize barley filtrate；
Gingko, lotus seeds, lily, mix, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours,
Extraction 1-3 times, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and dries, obtains gingko lotus seeds lily composition C2.
A kind of preparation method of the composition of yin-nourishing is：
Wheat, maize, barley, mix, crush, add 4-10 times to measure boiling boiling extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and merging filtered fluid is standby, obtains wheat maize barley filtrate；
Gingko, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours, extract 1-3 times, extraction
Liquid filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and dries, obtains gingko composition；
Lotus seeds, mix, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours, extract 1-3 times,
Extract solution filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and dries, obtains lotus seeds composition；
Lily, mix, crush, add 4-10 times to measure wheat maize barley filtrate and boil extraction 0.5-2 hours, extract 1-3 times,
Extract solution filters, and it is standby to merge filtered fluid；Filtered fluid concentrates, and dries, obtains lily composition；
Gingko composition, lotus seeds composition, lily composition, according to parts by weight (1-10)：(1-10)：(1-10) is mixed,
Obtain gingko lotus seeds lily composition D2.
A kind of composition of yin-nourishing, boiling granulating, sieving is filling, produces solid beverage.
A kind of composition of yin-nourishing, sweetener is added, Aspartame, Sucralose, boiling granulating, sieving is filling, produces
Solid beverage.
A kind of composition of yin-nourishing of the present invention, can prepare food, health products, health food, special medicine purposes work(
Can food, medicine, Chinese medicine.
A kind of composition of yin-nourishing of the present invention, food, health products, health care for nursing one's health yin-deficiency constitution can be prepared and eaten
Product, special medicine purposes functional food, medicine, Chinese medicine.
A kind of composition of yin-nourishing of the present invention, treatment constipation is being prepared, reducing blood pressure, reduce food on blood fat, guarantor
Strong product, health food, special medicine purposes functional food, medicine, the purposes of Chinese medicine.
A kind of composition of yin-nourishing of the present invention, for yin-deficiency constitution crowd, can by kilogram or in units of ton, also may be used
So that in grams, weight can increase or reduce, but the raw material weight proportioning of soup processed constant rate between each composition.
The characteristics of raw material involved in the present invention, is as follows：
The present invention analysis method be：
Assay：According to《Chinese Pharmacopoeia》2015 editions, high performance liquid chromatography (general rule 0512) measure.
Chromatographic condition and system suitability test：Octadecylsilane chemically bonded silica is filler；
Using 0.5% acetic acid (volume ratio) ethanol as mobile phase A, using acetonitrile as Mobile phase B,
Gradient elution is carried out according to the regulation in following table；25 DEG C of column temperature；Detection wavelength is 290nm.
The preparation of reference substance solution：Take liensinine, isoliensinine, reference material of neferine each 10 μ g are accurately weighed, put
In 1ml measuring bottles, methanol is added to shake up to 1ml scales, filter, produce.
The preparation of need testing solution：This product is taken, it is finely ground, 2.5g is taken, it is accurately weighed, put in 50ml measuring bottles, add methanol, ultrasound
Handle (power 400W, frequency 40kHz) 30 minutes, let cool, add methanol dilution to shake up to 50ml scales, filter, produce.
Determination method：It is accurate respectively to draw the μ l of reference substance solution 5, the μ l of need testing solution 5, liquid chromatograph is injected, is determined, i.e.,
.
The Log Analysis Method in Thin Layers of the lily of the present invention is as follows：
This product particle 1g is taken, finely ground, addition methanol 10ml, supersound process 30 minutes, filtrate is put water-bath and is evaporated, and residue adds
Methanol 1ml, as need testing solution.
Separately take lily control medicinal material 0.01g finely ground, add methanol 1ml, be ultrasonically treated 30 minutes, filtrate puts water-bath steaming
Dry, residue adds methanol 1ml, as lily control medicinal material solution.
Lily alkali reference substance is taken again, adds methanol and solution of every lml containing 0.05mg is made, it is molten as lily alkali reference substance
Liquid.
The μ l of lily alkali reference substance solution 1, need testing solution and the μ l of lily control medicinal material solution 6 are drawn, is put respectively in same
On silica gel g thin-layer plate, with chlorofonn-ethylacetate-acetic acid (20:5:1) upper solution is solvent, is deployed, and takes out, dries,
It is placed under ultraviolet lamp (365nm) and inspects.In test sample chromatogram, with lily alkali reference substance chromatogram and lily control medicinal material solution color
Compose on corresponding position, show the fluorescence spot of same color.
The preparation method A2-D2 prescription of composition of the present invention a kind of, preparation technology than this area conventional prescription and
The excellent of preparation technology.
The stability of product obtained by a kind of preparation method A-D of composition of the present invention, mouthfeel, active constituent content,
Effect, than the present invention a kind of composition preparation method A2-D2 obtained by product it is outstanding
Brief description of the drawings
Fig. 1：The HPLC collection of illustrative plates of the product of the present invention
Fig. 1 explanation：There are figure A, figure B two parts, 1 liensinine, 2 isoliensinines, 3 neferines in Fig. 1
It is standard items HPLC collection of illustrative plates to scheme A, and figure B is product HPLC collection of illustrative plates
Embodiment
Further detailed, complete explanation is done to the present invention with reference to embodiment.
Embodiment 1
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Gingko 10, lotus seeds 10, lily 20, crush,
100 mesh sieves are crossed, powder is made.
Embodiment 2
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Gingko 10, lotus seeds 10, lily 20, crush,
100 mesh sieves are crossed, adds 10 times of amount boiling boilings to extract 2 hours, extracts 3 times, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid is dense
Contracting, is concentrated into proportion 1.06；Concentrate centrifuge, extracting centrifugal liquid are standby；Centrifugate is spray-dried, and spray dryer enters
Air temperature is 180 DEG C, and leaving air temp is 100 DEG C；Take spray drying gained dry cream to crush, cross 80 mesh, obtain gingko lotus seeds lily group
Compound A
Embodiment 3
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 20, maize 20, barley 20, gingko
10, lotus seeds 10, lily 20, crush, cross 100 mesh sieves, add 10 times of amount boiling boilings to extract 2 hours, extract 3 times, extract solution filtering, close
And filtered fluid is standby；Filtered fluid concentrates, and is concentrated into proportion 1.06；Concentrate centrifuge, extracting centrifugal liquid are standby；Centrifugate
Spray drying, spray dryer EAT are 180 DEG C, and leaving air temp is 100 DEG C；Spray drying gained dry cream is taken to crush, mistake
80 mesh, obtain gingko lotus seeds lily composition B.
Embodiment 4
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 20, maize 20, barley 20, gingko
10, lotus seeds 10, lily 20,
Wheat, maize, barley, mix, crush, cross 100 mesh sieves, add 10 times of amount boilings to boil extraction 2 hours, extract 3 times, carry
Liquid is taken to filter, merging filtered fluid is standby, obtains wheat maize barley filtrate；
Gingko, lotus seeds, lily, mix, crush, cross 100 mesh sieves, add 10 times of amount wheat maize barley filtrates to boil extraction 2
Hour, extract 3 times, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06；Concentrate centrifuges
Machine centrifuges, and extracting centrifugal liquid is standby；Centrifugate is spray-dried, and spray dryer EAT is 180 DEG C, and leaving air temp is 100 DEG C；
Take spray drying gained dry cream to crush, cross 80 mesh, obtain gingko lotus seeds lily composition C.
Embodiment 5
A kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 20, maize 20, barley 20, gingko
10, lotus seeds 10, lily 20,
Wheat, maize, barley, mix, crush, cross 100 mesh sieves, add 10 times of amount boilings to boil extraction 2 hours, extract 3 times, carry
Liquid is taken to filter, merging filtered fluid is standby, obtains wheat maize barley filtrate；
Gingko, mix, crush, cross 100 mesh sieves, add 10 times of amount wheat maize barley filtrates to boil extraction 2 hours, extraction 3
It is secondary, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06；Concentrate centrifuge, takes
Centrifugate is standby；Centrifugate is spray-dried, and spray dryer EAT is 180 DEG C, and leaving air temp is 100 DEG C；Take spraying dry
Dry gained dry cream crushes, and crosses 80 mesh, obtains gingko composition；
Lotus seeds, mix, crush, cross 100 mesh sieves, add 10 times of amount wheat maize barley filtrates to boil extraction 2 hours, extraction 3
It is secondary, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06；Concentrate centrifuge, takes
Centrifugate is standby；Centrifugate is spray-dried, and spray dryer EAT is 180 DEG C, and leaving air temp is 100 DEG C；Take spraying dry
Dry gained dry cream crushes, and crosses 80 mesh, obtains lotus seeds composition；
Lily, mix, crush, cross 100 mesh sieves, add 10 times of amount wheat maize barley filtrates to boil extraction 2 hours, extraction 3
It is secondary, extract solution filtering, it is standby to merge filtered fluid；Filtered fluid concentrates, and is concentrated into proportion 1.06；Concentrate centrifuge, takes
Centrifugate is standby；Centrifugate is spray-dried, and spray dryer EAT is 180 DEG C, and leaving air temp is 100 DEG C；Take spraying dry
Dry gained dry cream crushes, and crosses 80 mesh, obtains lily composition；
Gingko composition, lotus seeds composition, lily composition, according to parts by weight 1：1：2 mixing, obtain gingko lotus seeds lily
Composition D.
Embodiment 6
According to gingko lotus seeds lily composition A20g, lactose 100g, superfine silica gel powder 20g, sodium carboxymethyl starch 20g is solvable
Property starch 200g, magnesium stearate 2g, be well mixed, tablet is made.
Embodiment 7
According to gingko lotus seeds lily composition A 20g, soluble starch 200g, dextrin 5g, talcum powder 1g, magnesium stearate
1g, it is well mixed, granule is made.
Embodiment 8
According to gingko lotus seeds lily composition B 20g, soluble starch 20g, dextrin 5g, the customary adjuvant of this area, mix
Close uniformly, electuary is made.
Embodiment 9
It is soluble according to gingko lotus seeds lily composition B20g, lactose 50g, superfine silica gel powder 20g, sodium carboxymethyl starch 20g
Starch 20g, magnesium stearate 2g, it is well mixed, tablet is made.
Embodiment 10
According to gingko lotus seeds lily composition B20g, soluble starch 20g, dextrin 5g, talcum powder 1g, magnesium stearate 1g,
It is well mixed, granule is made.
Embodiment 11
According to gingko lotus seeds lily composition C 20g, soluble starch 20g, dextrin 5g, the customary adjuvant of this area, mix
Close uniformly, electuary is made.
Embodiment 12
It is soluble according to gingko lotus seeds lily composition C20g, lactose 50g, superfine silica gel powder 20g, sodium carboxymethyl starch 20g
Starch 20g, magnesium stearate 2g, it is well mixed, tablet is made.
Embodiment 13
According to gingko lotus seeds lily composition C20g, soluble starch 20g, dextrin 5g, talcum powder 1g, magnesium stearate 1g,
It is well mixed, granule is made.
Embodiment 14
According to gingko lotus seeds lily composition D 20g, soluble starch 20g, dextrin 5g, the customary adjuvant of this area, mix
Close uniformly, electuary is made.
Embodiment 15
It is soluble according to gingko lotus seeds lily composition D20g, lactose 50g, superfine silica gel powder 20g, sodium carboxymethyl starch 20g
Starch 20g, magnesium stearate 2g, it is well mixed, tablet is made.
Embodiment 16
According to gingko lotus seeds lily composition D20g, soluble starch 20g, dextrin 5g, talcum powder 1g, magnesium stearate 1g,
It is well mixed, granule is made.
Embodiment 17
The particle 1g of Example 4, finely ground, addition methanol 10ml, supersound process 30 minutes, filtrate is put water-bath and is evaporated, residual
Slag adds methanol 1ml, as need testing solution.
Separately take lily control medicinal material 0.01g finely ground, add methanol 1ml, be ultrasonically treated 30 minutes, filtrate puts water-bath steaming
Dry, residue adds methanol 1ml, as lily control medicinal material solution.
Lily alkali reference substance is taken again, adds methanol and solution of every lml containing 0.05mg is made, it is molten as lily alkali reference substance
Liquid.
The μ l of lily alkali reference substance solution 1, need testing solution and the μ l of lily control medicinal material solution 6 are drawn, is put respectively in same
On silica gel g thin-layer plate, using the upper solution of chloroform (hexamethylene)-ethyl acetate acetic acid as solvent, deploy, take out, dry,
It is placed under ultraviolet lamp (365nm) and inspects.In test sample chromatogram, with lily alkali reference substance chromatogram and lily control medicinal material solution color
Compose on corresponding position, show the fluorescence spot of same color.
Deployed respectively with following solvent：
Cyclohexane-ethyl acetate-acetic acid (100:5:1) upper solution：A solvents
Cyclohexane-ethyl acetate-acetic acid (80:5:1) upper solution：B solvents
Cyclohexane-ethyl acetate-acetic acid (60:5:1) upper solution：C solvents
Chlorofonn-ethylacetate-acetic acid (40:5:1) upper solution：D solvents
Chlorofonn-ethylacetate-acetic acid (20:5:1) upper solution：E solvents
Chlorofonn-ethylacetate-acetic acid (10:5:1) upper solution：F solvents
Chlorofonn-ethylacetate-acetic acid (5:5:1) upper solution：G solvents
Expansion, take out, dry, be placed under ultraviolet lamp (365nm) and inspect.In test sample chromatogram, with lily alkali reference substance
In chromatogram and the corresponding position of lily control medicinal material solution chromatogram, show the fluorescence spot of same color.
Interpretation of result：
Deployed with A solvents, B solvents, C solvents, medicinal material spot and R f value is between 0.1 ﹣ 0.3, spot separation
Difference, colour developing is fuzzy, does not reach the purpose of discriminating；
Deployed with D solvents, F solvents, G solvents, medicinal material spot and R f value is between 0.2 ﹣ 0.5, spot separation
Typically；
Deployed with E solvents, medicinal material spot and R f value separates well between 0.5 ﹣ 0.8, and colour developing is clear；Have compared with
Good expansion effect.
Assay：According to《Chinese Pharmacopoeia》2015 editions, high performance liquid chromatography (general rule 0512) measure.
Chromatographic condition and system suitability test：Octadecylsilane chemically bonded silica is filler；
25 DEG C of column temperature；Detection wavelength is 290nm.
Using 0.5% acetic acid (volume ratio) ethanol as mobile phase A, using acetonitrile as Mobile phase B, carried out according to the regulation in following table
Gradient elution；
The preparation of reference substance solution：Take liensinine, isoliensinine, reference material of neferine each 10 μ g are accurately weighed, put
In 1ml measuring bottles, methanol is added to shake up to 1ml scales, filter, produce.
The preparation of need testing solution：This product particle of Example 13, it is finely ground, 2.5g is taken, it is accurately weighed, put 50ml measuring bottles
In, add methanol, be ultrasonically treated (power 400W, frequency 40kHz) 30 minutes, let cool, add methanol dilution to shake up to 50ml scales,
Filtration, is produced.
Determination method：It is accurate respectively to draw the μ l of reference substance solution 5, the μ l of need testing solution 5, liquid chromatograph is injected, is determined, i.e.,
.
Methodological study
Specificity is investigated
Precision draws the μ l of mixed reference substance solution 10, need testing solution and the μ l of negative need testing solution 20, measure, as a result shows
Show, negative need testing solution with liensinine, isoliensinine, do not have chromatogram at the identical retention time of reference material of neferine
Peak, show that feminine gender does not interfere with.
Linear relationship is investigated
Precision draws μ l of mixed reference substance solution 2,3 μ l, 5 μ l, 10 μ l, 15 μ l, 20 μ l injection high performance liquid chromatographs, note
Record peak liensinine, isoliensinine, neferine peak area, with reference substance content (X) for abscissa, reference substance peak area (Y)
Canonical plotting is drawn for ordinate, the results showed that linear relationship is good.
Precision test
Precision draws the μ l of mixed reference substance solution 10,6 measure of continuous sample introduction, records liensinine, isoliensinine, methyl lotus
Heart alkali peak area, its RSD value is calculated, as a result illustrate that precision is good.
Stability test
Need testing solution is prepared, high performance liquid chromatograph is injected, was measured respectively at 0,2,4,6,8,12 hour, is recorded
Liensinine, isoliensinine, neferine peak area, its RSD value is calculated, is had good stability.
Replica test
6 parts of need testing solutions of parallel preparation, injection high performance liquid chromatograph are measured, and record peak area, the results showed that
It is repeated good.
Average recovery is tested
Need testing solution is prepared, injects high performance liquid chromatograph, records peak area, liensinine, isoliensinine, methyl lotus nut
Alkali average recovery meets the requirements.
Embodiment 18
Long-term treaitng Yin-deficiency constipation crowd, is randomly divided into observation group 30 and control group 30.
Observation group：Man 18, female 12, the age (38.5 ± 6.5) year, the course of disease (6.5 ± 3.5) year.
Control group：Man 17, female 13, the age (37.5 ± 3.5) year, the course of disease (4.5 ± 2.5) year.
Two groups of Genders, age, the course of disease, state of an illness, there is comparativity.
Following 2 symptoms of at least 12 weeks tools:
>1/4 time defecation is laborious；
>1/4 time excrement is in lumps or hard；
>1/4 time had defecation to feel not to the utmost；
>1/4 time anus has obstruction or discharge difficult；
>Handball Association is needed to help during 1/4 time defecation；
Defecation weekly<3 times.
The oral fructose oral liquid of control group, each 10m1, every 3 times, warm water is taken before meals.
The oral gingko lotus seeds lily composition C of observation group, 5 grams every time, 3 times a day, warm water is taken before meals
Two groups of continuous treatments 3 weeks, are not used other defaecation medicines during treatment, record patient's stool and secondary, with
And whether there is the symptoms such as stomachache, abdominal distension, poor appetite.Compare two groups of patient's defecation times, defecation efficiency, stool number and row
Just the clinical therapeutic efficacy in terms of degree of difficulty.
Curative effect judging standard：
Recovery from illness:Stool interval, 2d, stool soften, and defecation is smooth；
It is effective:Constipation symptom is obviously improved, and close to normally, shit quality is slightly dry and hard for each infrequent defecation time and just matter,
But the infrequent defecation time is within 3d；
Effectively:There is shortening the infrequent defecation time earlier above, and just the dry and hard situation of matter makes moderate progress；
It is invalid:Constipation symptom is without improvement after medication.
Clinical efficacy
Treatment group：17 are cured, is taken a turn for the better 5, invalid 8.
Control group：26 are cured, is taken a turn for the better 3, invalid 1.
Claims (8)
1. a kind of composition of yin-nourishing, it is made up of the following raw material：Gingko, lotus seeds, lily.
2. a kind of composition of yin-nourishing, it is made up of the following raw material：Wheat, maize, barley, gingko, lotus seeds, lily.
3. a kind of composition of yin-nourishing, it is made up of the following raw material：Gingko, lotus seeds, lily.
4. a kind of composition of yin-nourishing, it is made up of the following raw material：Wheat, maize, barley, gingko, lotus seeds, lily.
5. a kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Gingko 1-10, lotus seeds 1-20, lily 1-10.
6. a kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Gingko 10, lotus seeds 20, lily 10.
7. a kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 1-20, maize 1-20, barley 1-20, in vain
Fruit 1-10, lotus seeds 1-20, lily 1-10.
8. a kind of composition of yin-nourishing, it is made up of the raw material of following parts by weight：Wheat 20, maize 20, barley 20, gingko 10,
Lotus seeds 20, lily 10.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112515168A (en) * | 2020-12-18 | 2021-03-19 | 江苏师范大学 | Functional food composition for losing weight and reducing blood fat of yin-deficiency obese constitution and preparation method thereof |
| CN112826013A (en) * | 2020-11-30 | 2021-05-25 | 徐新友 | Porridge powder suitable for constipation and preparation method thereof |
-
2017
- 2017-11-02 CN CN201711063153.0A patent/CN107753727A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112826013A (en) * | 2020-11-30 | 2021-05-25 | 徐新友 | Porridge powder suitable for constipation and preparation method thereof |
| CN112515168A (en) * | 2020-12-18 | 2021-03-19 | 江苏师范大学 | Functional food composition for losing weight and reducing blood fat of yin-deficiency obese constitution and preparation method thereof |
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Application publication date: 20180306 |
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