CN107149610A - A kind of cynomorium songaricum capsule and preparation method thereof - Google Patents
A kind of cynomorium songaricum capsule and preparation method thereof Download PDFInfo
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- CN107149610A CN107149610A CN201710373427.XA CN201710373427A CN107149610A CN 107149610 A CN107149610 A CN 107149610A CN 201710373427 A CN201710373427 A CN 201710373427A CN 107149610 A CN107149610 A CN 107149610A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61K9/4841—Filling excipients; Inactive ingredients
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of cynomorium songaricum capsule, it is made up of capsule softgel shell and the content being wrapped in the capsule softgel shell, the content includes Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, B family vitamin, the first suspending agent and the second suspending agent.The invention also discloses a kind of preparation method of cynomorium songaricum capsule, including：Prepare Herba Cynomorii extract；The first suspending agent and the second suspending agent are added into safflower seed oil, suspension base oil is obtained；B family vitamin, fish oil, granular Herba Cynomorii extract and granular carthamin yellow are added into suspension base oil, thick suspended oil is obtained, and high-pressure homogeneous processing is carried out to thick suspended oil；Prepare capsule capsule shell fluid；Capsule capsule shell fluid and thick suspended oil are placed in incubator, rolling molding ball, sizing, washing are carried out after mixing and is dried.The cynomorium songaricum capsule that the present invention is prepared using method simple to operate ensure that the stability and the uniformity of content, has effects that kidney tonifying, is healthy and strong, protects heart and brain blood, strengthen immunity.
Description
Technical field
The present invention relates to technical field of medicine, it is more particularly related to a kind of cynomorium songaricum capsule and its preparation
Method.
Background technology
Cynomorium songaricum, a kind of parasitic plant, medicine alias ground ball top, rust iron staff, Songaria Cynomorium Herb, have strengthening the essence Xing Yang, moisturize nourishing the muscle and tendon, it is big
Tonifying yin gas, benefiting essence-blood, the effect of profit stool.With kidney-replenishing, benefiting essence-blood, relax bowel, nourishing the muscle and tendon the effect of, be usually used in treat kidney
The symptom such as YANG deficiency, blood and essence asthenia, infertile, waist knee flaccidity, dry constipation of intestines, neurasthenia.Modern pharmacological research finds cynomorium songaricum tool
Have enhancing sexual function of human body, enhancing Immune Function In Animals, remove free radical, it is anti-oxidant and anti-aging, resist oxygen lack, resisting stress, anti-
Fatigue, have to glucocorticoid dual regulation, platelet aggregation-against, relax bowel, antitumor, anti-ulcer effect and
Suppress the multiple pharmacological effects such as the propagation of AIDS virus.The main component of cynomorium songaricum is cynomorium songaricum general flavone, cynomorium songaricum polysaccharide etc., cynomorium songaricum
The pharmacological action of general flavone has removing free radical, anti-oxidant and anti-aging, resist oxygen lack, resisting stress, antifatigue and enhancing animal to exempt from
Epidemic disease function etc..Cynomorium songaricum is warm-natured sweet, kidney tonifying but its property is warm but not dry, and it, which is imitated, mends without high, and cynomorium songaricum is enriching yin and nourishing kidney, it is supporing yang and
Not impairment of yin, can Yin Yang balancing, either the deficiency of yang or the deficiency of Yin can all use it.
Application publication number discloses a kind of saline cistanche cynomorium songaricum health care spansule for the A of CN 103141843 Chinese patent,
Content in spansule is by saline cistanche, cynomorium songaricum, keel, Poria cocos, mulberries, matrimony vine, Chinese yam, cultivated land, Semen Cuscutae, five tastes subgroup
Into, and by being well mixed and pill after each component is crushed, the combination of a variety of medicinal materials substantially increases health care spansule
Cost.
Application publication number discloses a kind of extracting method of Herba Cynomorii extract for the A of CN 105796613 Chinese patent, no
It can guarantee that the purity of Herba Cynomorii extract.
Application publication number discloses a kind of cynomorium songaricum health-care tablet and preparation method thereof for the A of CN 105030858 Chinese patent,
It is raw material by Herba Cynomorii extract, inositol, amylum pregelatinisatum, polyvinylpyrrolidone, flavoring apple essence, mannitol, talcum powder, water,
The cooperation of Herba Cynomorii extract and inositol serves antifatigue effect, but function is still more single, it is impossible to meet the demand of health care.
The content of the invention
It is an object of the invention to solve at least the above, and provide the advantage that at least will be described later.
It is a still further object of the present invention to provide a kind of cynomorium songaricum capsule, the cynomorium songaricum capsule is soft capsule, and be ensure that
Suspension degree of the uniformity and solid particle of content in capsule softgel shell in oil, substantially increases the stabilization of cynomorium songaricum capsule
Property, while the cynomorium songaricum capsule also has kidney tonifying, is healthy and strong, protect heart and brain blood, strengthen immunity, strengthen memory, physical and mental health
Effect.
It is a still further object of the present invention to provide a kind of preparation method of cynomorium songaricum capsule, its preparation method is simple, simultaneously
The preparation method ensure that the stability of cynomorium songaricum capsule, it is ensured that the medical value and health value of cynomorium songaricum capsule, it is ensured that people
Body can effectively absorb the drug effect of the content of cynomorium songaricum capsule.
To achieve these goals, the invention provides a kind of cynomorium songaricum capsule, by capsule softgel shell and being wrapped in the capsule
Content composition in softgel shell, the content includes Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, the dimension life of B races
Element, the first suspending agent and the second suspending agent, the Herba Cynomorii extract, the safflower seed oil, the fish oil, the safflower yellow
The mass ratio of plain, described B family vitamin, first suspending agent and second suspending agent is 12~18/100/5~7/10
~15/0.02~0.08/2~4/0~0.1.
Preferably, wherein, first suspending agent be sucrose fatty ester, second suspending agent be soybean lecithin.
Preferably, wherein, the Herba Cynomorii extract, the safflower seed oil, the fish oil, the carthamin yellow, institute
The mass ratio for stating B family vitamin, first suspending agent and second suspending agent is 15:100:6:12:0.06:3:
0.05。
Preferably, wherein, the capsule softgel shell is made up of glycerine, gelatin, curcumin and water.
The invention also discloses a kind of preparation method of cynomorium songaricum capsule, comprise the following steps：
Step 1: using cynomorium songaricum as raw material, being extracted from cynomorium songaricum and preparing granular Herba Cynomorii extract；
Step 2: adding the first suspending agent and the second suspending agent into safflower seed oil, it is stored at room temperature, removes after grinding is uniform
Insoluble matter, obtains suspension base oil；
Step 3: adding B family vitamin, fish oil, granular Herba Cynomorii extract and graininess into the suspension base oil
Carthamin yellow, be ground to being stored at room temperature after uniform, remove insoluble matter, obtain thick suspended oil, and thick suspended to described
Oil carries out high-pressure homogeneous processing；
Step 4: using gelatin, glycerine, curcumin and water as raw material, preparing capsule capsule shell fluid；
Step 5: by the capsule capsule shell fluid and it is high-pressure homogeneous after thick suspended oil be placed in incubator, after mixing carry out
Rolling is molded ball, sizing, washing and dried, and obtains cynomorium songaricum capsule.
Preferably, wherein, the preparation process of the granular Herba Cynomorii extract is：
S1, using pulverizer dry cynomorium songaricum is crushed, the cynomorium songaricum coarse powder of 150 mesh is obtained, using water extraction to institute
State cynomorium songaricum coarse powder to be extracted, the extract solution that extraction is obtained is filtered, and collect filtrate；
S2, using microfiltration membranes, milipore filter and nano filter membrane the filtrate is filtered, obtain permeate；
S3, carry out separation concentration and lyophilization successively to the permeate, obtain granular Herba Cynomorii extract.
Preferably, wherein, the granularity of the carthamin yellow is 255 mesh, and the granularity of the Herba Cynomorii extract is 280
Mesh.
Preferably, wherein, the preparation process of the capsule capsule shell fluid is：
First, according to gelatin：Glycerine：The mass ratio of water is 1：0.3~0.5：1 relation also known as take gelatin, glycerine and
Water, and weigh the gelatin, 0.3% curcumin of G ＆ W gross weight；
Then, gelatin is placed in the water of part and be dipped to the gelatin and be fully swelled, obtain gelatin solution；
Finally, it is placed in after remaining water is mixed with glycerine in glue pot, and is heated to 70 DEG C, then adds the gelatin
Liquid, 1~1.5h of stirring is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, let cool to 60 DEG C, and
Insulation standing is carried out at 60 DEG C, the foam floated is removed, capsule capsule shell fluid is obtained after filtering；
Wherein, the mass ratio of the part water and the remaining water is 3:1.
Preferably, wherein, it is described sizing, washing and drying process be specially：
After rolling molding ball, in the pill-rolling 6h that dried at 25 DEG C to shape, capsule is obtained；
Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；
By the capsule after washing in being dried up 4 hours in net machine, cynomorium songaricum capsule is obtained.
The present invention at least includes following beneficial effect：
1st, there is the Herba Cynomorii extract in the content of cynomorium songaricum capsule of the present invention kidney-replenishing, benefiting essence-blood, ease constipation to lead to
Just the linoleic acid in, nourishing the muscle and tendon, antifatigue and anti-aging effect, safflower seed oil can prevent and treat cardiovascular and cerebrovascular disease and three high, and
And the vitamin E in safflower seed oil has the effect of anti-aging, carthamin yellow has stasis-dispelling and pain-killing, reduction cholesterol, drop blood
The effect of pressure, can be prevented heart disease and coronary heart disease and health care, and the cooperation of fish oil and B family vitamin, which can supplement brain, to be needed
The nutriment wanted, plays effect of physical and mental health, when the first suspending agent and the second suspending agent ensure that each component can be long
Between be suspended in safflower seed oil and a small amount of fish oil in, and the weight proportion of other components so that cynomorium songaricum capsule has excellent
Health properties.
2nd, the preparation method for the cynomorium songaricum capsule that the present invention is provided is simple, and the industrialization for realizing cynomorium songaricum capsule is quickly produced.
3rd, the extracting method for the Herba Cynomorii extract that the present invention is provided ensure that the recovery rate and purity of Herba Cynomorii extract, protect
The health-care efficacy of Herba Cynomorii extract is demonstrate,proved.
Further advantage, target and the feature of the present invention embodies part by following explanation, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Embodiment
With reference to specific embodiment, the present invention is described in further detail, to make those skilled in the art's reference say
Bright book word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded from one or many
The presence or addition of individual other elements or its combination.
Embodiment 1：
The invention provides a kind of cynomorium songaricum capsule, it is made up of capsule softgel shell and the content being wrapped in capsule softgel shell, it is interior
It is tolerant including Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, B family vitamin, sucrose fatty ester and soybean phosphorus
Fat, wherein, Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, B family vitamin, sucrose fatty ester and soybean lecithin
Mass ratio be 18:100:7:15:0.08:4:0.1.
The preparation method of above-mentioned cynomorium songaricum capsule is：
Step 1: using cynomorium songaricum as raw material, being extracted from cynomorium songaricum and preparing granular Herba Cynomorii extract；
S1, using pulverizer dry cynomorium songaricum is crushed, the cynomorium songaricum coarse powder of 150 mesh is obtained, using water extraction to institute
State cynomorium songaricum coarse powder to be extracted, the extract solution that extraction is obtained is filtered, and collect filtrate；
S2, using microfiltration membranes, milipore filter and nano filter membrane the filtrate is filtered, obtain permeate；
S3, carry out separation concentration and lyophilization successively to the permeate, obtain the cynomorium songaricum that granularity is 255 mesh and extract
Thing.
Extracting includes once extracting and second extraction：Cynomorium songaricum coarse powder is put into extractor, first is added into extractor
The water of quality, carries out first time extraction, extraction time is 1.5h, obtains an extract solution at a temperature of 50 DEG C；
The water of the second mass is added in cynomorium songaricum coarse powder to after once extracting, second is carried out at a temperature of 61 DEG C and is soaked
Carry, extraction time is 1.0h, obtains secondary raffinate；And collect an extract solution and it is filtered, so as to be filtered
Liquid, and it regard the water of the second mass as secondary raffinate as the secondary of next batch as an Extraction solvent of next batch
Extraction solvent.
Step 2: adding sucrose fatty ester and soybean lecithin into safflower seed oil, it is stored at room temperature, removes after grinding is uniform
Insoluble matter, obtains suspension base oil；
Step 3: addition B family vitamin, fish oil, the Herba Cynomorii extract and granularity that granularity is 255 mesh are into suspension base oil
The carthamin yellow of 255 mesh, is ground to being stored at room temperature after uniform, removes insoluble matter, obtain thick suspended oil, and to described thick
Suspended oil carries out high-pressure homogeneous processing；Homogenization pressure is 18Mpa, and homogenizing time is 22min；Degassing pressure is less than -0.10MPa,
Degassing temperature is 97 DEG C, and degassing time is 2 hours；
Step 4: using gelatin, glycerine, curcumin and water as raw material, preparing capsule capsule shell fluid；
First, according to gelatin：Glycerine：The mass ratio of water is 1：0.35：1 relation also known as takes gelatin, G ＆ W, and
Weigh the gelatin, 0.3% curcumin of G ＆ W gross weight；Then, gelatin is placed in the water of part and be dipped to
The gelatin is fully swelled, and obtains gelatin solution；Finally, it is placed in after remaining water is mixed with glycerine in glue pot, and is heated to 70
DEG C, the gelatin solution is then added, stirring 1h is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed, put
It is cooled to 60 DEG C, and insulation standing is carried out at 60 DEG C, removes the foam floated, capsule capsule shell fluid is obtained after filtering；The part water
Mass ratio with the remaining water is 3:1；
Step 5: by capsule capsule shell fluid and it is high-pressure homogeneous after thick suspended oil be placed in incubator, after mixing carry out rolling mould
Pelleting, sizing, washing and drying, obtain cynomorium songaricum capsule.After rolling molding ball, in the pill-rolling 6h that dried at 25 DEG C to shape, obtain
Capsule；Soft capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；By the flexible glue after washing
Capsule obtains cynomorium songaricum capsule in being dried up 4 hours in net machine.
Embodiment 2：
The invention provides a kind of cynomorium songaricum capsule, it is made up of capsule softgel shell and the content being wrapped in capsule softgel shell, glue
Capsule softgel shell is made up of glycerine, gelatin, curcumin and water, and content includes Herba Cynomorii extract, safflower seed oil, fish oil, safflower yellow
Element, B family vitamin, sucrose fatty ester and soybean lecithin, Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, B races
The mass ratio of vitamin, sucrose fatty ester and soybean lecithin is 12:100:5:10:0.02:2:0.05.
The invention also discloses a kind of preparation method of cynomorium songaricum capsule, comprise the following steps：
Step 1: using cynomorium songaricum as raw material, being extracted from cynomorium songaricum and preparing granular Herba Cynomorii extract；
S1, using pulverizer dry cynomorium songaricum is crushed, the cynomorium songaricum coarse powder of 150 mesh is obtained, using water extraction to institute
State cynomorium songaricum coarse powder to be extracted, the extract solution that extraction is obtained is filtered, and collect filtrate；
S2, using microfiltration membranes, milipore filter and nano filter membrane the filtrate is filtered, obtain permeate；
S3, carry out separation concentration and lyophilization successively to the permeate, obtain the cynomorium songaricum that granularity is 280 mesh and extract
Thing.
Step 2: adding sucrose fatty ester and soybean lecithin into safflower seed oil, it is stored at room temperature, removes after grinding is uniform
Insoluble matter, obtains suspension base oil；
Step 3: addition B family vitamin, fish oil, the Herba Cynomorii extract and granularity that granularity is 280 mesh are into suspension base oil
The carthamin yellow of 300 mesh, is ground to being stored at room temperature after uniform, removes insoluble matter, obtain thick suspended oil, and to thick suspension
Oil carries out high-pressure homogeneous processing；Homogenization pressure is 18Mpa, and homogenizing time is 22min；Degassing pressure is less than -0.10MPa, degassing
Temperature is 97 DEG C, and degassing time is 2 hours；
Step 4: using gelatin, glycerine, curcumin and water as raw material, preparing capsule capsule shell fluid；
First, according to gelatin：Glycerine：The mass ratio of water is 1：0.3：1 relation also known as takes gelatin, G ＆ W, and
Weigh the gelatin, 0.3% curcumin of G ＆ W gross weight；Then, gelatin is placed in the water of part and be dipped to
The gelatin is fully swelled, and obtains gelatin solution；Finally, it is placed in after remaining water is mixed with glycerine in glue pot, and is heated to 70
DEG C, the gelatin solution is then added, stirring 1.5h is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed,
Let cool to 60 DEG C, and insulation standing is carried out at 60 DEG C, remove the foam floated, capsule capsule shell fluid is obtained after filtering；Part water with
The mass ratio of remaining water is 3:1；
Step 5: by the capsule capsule shell fluid and it is high-pressure homogeneous after thick suspended oil be placed in incubator, after mixing carry out
Rolling is molded ball, sizing, washing and dried, and obtains cynomorium songaricum capsule.After rolling molding ball, in the pill-rolling 6h that dried at 25 DEG C to shape,
Obtain capsule；Soft capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；After washing
Soft capsule obtains cynomorium songaricum capsule in being dried up 4 hours in net machine.
Embodiment 3：
The invention provides a kind of cynomorium songaricum capsule, it is made up of capsule softgel shell and the content being wrapped in capsule softgel shell, glue
Capsule softgel shell is made up of glycerine, gelatin, curcumin and water, and content includes Herba Cynomorii extract, safflower seed oil, fish oil, safflower yellow
Element, B family vitamin, sucrose fatty ester and soybean lecithin, Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, B races
The mass ratio of vitamin, sucrose fatty ester and soybean lecithin is 15:100:6:12:0.06:3:0.05.
The invention also discloses a kind of preparation method of cynomorium songaricum capsule, comprise the following steps：
Step 1: using cynomorium songaricum as raw material, being extracted from cynomorium songaricum and preparing granular Herba Cynomorii extract；
S1, using pulverizer dry cynomorium songaricum is crushed, the cynomorium songaricum coarse powder of 150 mesh is obtained, using water extraction to institute
State cynomorium songaricum coarse powder to be extracted, the extract solution that extraction is obtained is filtered, and collect filtrate；
S2, using microfiltration membranes, milipore filter and nano filter membrane the filtrate is filtered, obtain permeate；
S3, carry out separation concentration and lyophilization successively to the permeate, obtain the cynomorium songaricum that granularity is 240 mesh and extract
Thing.
Step 2: adding sucrose fatty ester and soybean lecithin into safflower seed oil, it is stored at room temperature, removes after grinding is uniform
Insoluble matter, obtains suspension base oil；
Step 3: addition B family vitamin, fish oil, the Herba Cynomorii extract and granularity that granularity is 240 mesh are into suspension base oil
The carthamin yellow of 290 mesh, is ground to being stored at room temperature after uniform, removes insoluble matter, obtain thick suspended oil, and to thick suspension
Oil carries out high-pressure homogeneous processing；Homogenization pressure is 18Mpa, and homogenizing time is 22min；Degassing pressure is less than -0.10MPa, degassing
Temperature is 97 DEG C, and degassing time is 2 hours；
Step 4: using gelatin, glycerine, curcumin and water as raw material, preparing capsule capsule shell fluid；
First, according to gelatin：Glycerine：The mass ratio of water is 1：0.4：1 relation also known as takes gelatin, G ＆ W, and
Weigh the gelatin, 0.3% curcumin of G ＆ W gross weight；Then, gelatin is placed in the water of part and be dipped to
The gelatin is fully swelled, and obtains gelatin solution；Finally, it is placed in after remaining water is mixed with glycerine in glue pot, and is heated to 70
DEG C, the gelatin solution is then added, stirring 1.8h is allowed to melting completely uniformly, adds curcumin, and stirring makes to be well mixed,
Let cool to 60 DEG C, and insulation standing is carried out at 60 DEG C, remove the foam floated, capsule capsule shell fluid is obtained after filtering；Part water with
The mass ratio of remaining water is 3:1.
Step 5: by the capsule capsule shell fluid and it is high-pressure homogeneous after thick suspended oil be placed in incubator, after mixing carry out
Rolling is molded ball, sizing, washing and dried, and obtains cynomorium songaricum capsule.After rolling molding ball, in the pill-rolling 6h that dried at 25 DEG C to shape,
Obtain capsule；Soft capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；After washing
Soft capsule obtains cynomorium songaricum capsule in being dried up 4 hours in net machine.
Performance test is carried out to cynomorium songaricum capsule prepared by embodiment 1~3, shows the matter of sucrose fatty ester and soybean lecithin
Amount ensure that the stabilization time of content more than 100 hours, meets the demand that capsule makes stabilization time, improves cynomorium songaricum glue
The stability of capsule.And clinical application effect is good, modern society is met because air, food security and operating pressure are caused
Sub-health population get well the demand of constitution.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art
Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, the present invention is not limited
In specific details.
Claims (9)
1. a kind of cynomorium songaricum capsule, is made up of, it is characterised in that institute capsule softgel shell and the content being wrapped in the capsule softgel shell
Stating content includes Herba Cynomorii extract, safflower seed oil, fish oil, carthamin yellow, B family vitamin, the first suspending agent and second
Suspending agent, it is the Herba Cynomorii extract, the safflower seed oil, the fish oil, the carthamin yellow, the B family vitamin, described
The mass ratio of first suspending agent and second suspending agent is 12~18/100/5~7/10~15/0.02~0.08/2~4/
0~0.1.
2. a kind of cynomorium songaricum capsule according to claim 1, it is characterised in that first suspending agent is sucrose-fatty
Ester, second suspending agent is soybean lecithin.
3. a kind of cynomorium songaricum capsule according to claim 1, it is characterised in that the Herba Cynomorii extract, the safflower seed oil,
The quality of the fish oil, the carthamin yellow, the B family vitamin, first suspending agent and second suspending agent it
Than for 15:100:6:12:0.06:3:0.05.
4. a kind of cynomorium songaricum capsule according to claim 3, it is characterised in that the capsule softgel shell is by glycerine, gelatin, turmeric
Element and water are made.
5. a kind of method of the cynomorium songaricum capsule prepared according to any one of Claims 1 to 4, it is characterised in that including following
Step：
Step 1: using cynomorium songaricum as raw material, being extracted from cynomorium songaricum and preparing granular Herba Cynomorii extract；
Step 2: adding the first suspending agent and the second suspending agent into safflower seed oil, it is stored at room temperature, removes insoluble after grinding is uniform
Thing, obtains suspension base oil；
Step 3: adding B family vitamin, fish oil, granular Herba Cynomorii extract and granular red into the suspension base oil
Anthoxanthin, is ground to being stored at room temperature after uniform, removes insoluble matter, obtain thick suspended oil, and the thick suspended oil is entered
Horizontal high voltage homogenization；
Step 4: using gelatin, glycerine, curcumin and water as raw material, preparing capsule capsule shell fluid；
Step 5: by the capsule capsule shell fluid and it is high-pressure homogeneous after thick suspended oil be placed in incubator, after mixing carry out rolling mould
Pelleting, sizing, washing and drying, obtain cynomorium songaricum capsule.
6. the preparation method of a kind of cynomorium songaricum capsule according to claim 5, it is characterised in that the granular cynomorium songaricum is carried
The preparation process for taking thing is：
S1, using pulverizer dry cynomorium songaricum is crushed, the cynomorium songaricum coarse powder of 150 mesh is obtained, using water extraction to the lock
Positive coarse powder is extracted, and the extract solution that extraction is obtained is filtered, and collect filtrate；
S2, using microfiltration membranes, milipore filter and nano filter membrane the filtrate is filtered, obtain permeate；
S3, carry out separation concentration and lyophilization successively to the permeate, obtain granular Herba Cynomorii extract.
7. a kind of preparation method of cynomorium songaricum capsule according to claim 5, it is characterised in that the grain of the carthamin yellow
Spend for 255 mesh, the granularity of the Herba Cynomorii extract is 280 mesh.
8. the preparation method of a kind of cynomorium songaricum capsule according to claim 5, it is characterised in that described in the step 4
The preparation process of capsule capsule shell fluid is：
First, according to gelatin：Glycerine：The mass ratio of water is 1：0.3~0.5：1 relation also known as takes gelatin, G ＆ W, and
Weigh the gelatin, 0.3% curcumin of G ＆ W gross weight；
Then, gelatin is placed in the water of part and be dipped to the gelatin and be fully swelled, obtain gelatin solution；
Finally, it is placed in after remaining water is mixed with glycerine in glue pot, and is heated to 70 DEG C, is then added the gelatin solution, stir
Mix 1~1.5h and be allowed to melting completely uniformly, add curcumin, stirring makes to be well mixed, let cool to 60 DEG C, and at 60 DEG C
Insulation standing is carried out, the foam floated is removed, capsule capsule shell fluid is obtained after filtering；
Wherein, the mass ratio of the part water and the remaining water is 3:1.
9. the preparation method of a kind of cynomorium songaricum capsule according to claim 5, it is characterised in that described in the step 5
Sizing, washing and drying process are specially：
After rolling molding ball, in the pill-rolling 6h that dried at 25 DEG C to shape, capsule is obtained；
Capsule surface oil reservoir is washed away in pill wiping machine is washed with ethanol, and dries up the washing lotion of capsule surface；
By the capsule after washing in being dried up 4 hours in net machine, cynomorium songaricum capsule is obtained.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030858A (en) * | 2015-09-06 | 2015-11-11 | 青海之也科技咨询服务有限公司 | Cynomorium songaricum healthcare tablet and preparation method thereof |
| CN105796613A (en) * | 2014-12-30 | 2016-07-27 | 李志润 | Extraction method of Cynomorium songaricum extract |
| CN106176868A (en) * | 2016-09-27 | 2016-12-07 | 乌鲁木齐上善元生物科技有限公司 | A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof |
| CN106490622A (en) * | 2016-10-28 | 2017-03-15 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of fish oil soft capsule |
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- 2017-05-24 CN CN201710373427.XA patent/CN107149610A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796613A (en) * | 2014-12-30 | 2016-07-27 | 李志润 | Extraction method of Cynomorium songaricum extract |
| CN105030858A (en) * | 2015-09-06 | 2015-11-11 | 青海之也科技咨询服务有限公司 | Cynomorium songaricum healthcare tablet and preparation method thereof |
| CN106176868A (en) * | 2016-09-27 | 2016-12-07 | 乌鲁木齐上善元生物科技有限公司 | A kind of procyanidin Carthamus yellow composite soft capsule and preparation method thereof |
| CN106490622A (en) * | 2016-10-28 | 2017-03-15 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of fish oil soft capsule |
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Application publication date: 20170912 |