CN112426494A - Composition, preparation method and application thereof - Google Patents
Composition, preparation method and application thereof Download PDFInfo
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- CN112426494A CN112426494A CN202011444705.4A CN202011444705A CN112426494A CN 112426494 A CN112426494 A CN 112426494A CN 202011444705 A CN202011444705 A CN 202011444705A CN 112426494 A CN112426494 A CN 112426494A
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Abstract
The invention provides a composition for eliminating dampness and strengthening spleen. The composition comprises: the red bean food comprises 1-2 parts by mass of red bean, 0.5-1.5 parts by mass of coix seed and 0.2-0.8 part by mass of poria cocos. The composition provided by the invention has the effects of clearing damp and tonifying spleen, can effectively relieve the symptoms of abdominal fullness and distention, inappetence, dry and sticky mouth, halitosis, loose stool, body sleepiness and hypodynamia, heavy limbs and excessive phlegm, and is reasonable in Chinese medicine compatibility, convenient to use, safe and nontoxic.
Description
Technical Field
The invention belongs to the field of food and medicine, and particularly relates to a composition, a method for preparing the composition, application of the composition in preparing food or medicine, a beverage and a pharmaceutical composition.
Background
Food and water enter the human body and are transformed into fine substances such as body fluids through the transportation and transformation of the spleen and stomach. If food and water are not normally transported and absorbed, the symptom of water-wet in traditional Chinese medicine can be caused. Whether food and water eaten by human body can be transformed into fine substances required by human body is critical to whether the spleen and stomach function is strong, and the spleen and stomach are the acquired root and mainly transport and resolve water dampness. If the spleen and stomach are fatigued, the food grain can not be transformed into the useful delicate substance after entering the human body, but into the pathological product-water-dampness. The traditional Chinese medicine holds that the dampness is accumulated as water, the accumulated water is accumulated into water and the water is condensed into phlegm, the water is accumulated too much and becomes water, and the water is accumulated too long and becomes phlegm.
On the other hand, due to climate change, people's living habits are bad, and factors such as air conditioning are excessively depended on, so that wind-cold-dampness pathogen easily invades the human body, and the moisture of the human body is aggravated.
Phlegm and water-dampness which has not yet been coagulated into phlegm are gathered together to form phlegm-dampness, and the phlegm-dampness flows everywhere along with qi in the body: stay in the liver, so that fatty liver is formed; if the waist is retained between the waist, the abdomen and the bucket waist are formed; edema and bloated due to overflow of the skin, muscles, face and limbs; it is also prone to cause irregular menstruation, leukorrhagia, lumbago, headache, and cervical spondylosis.
At present, dampness-eliminating and spleen-tonifying products on the market mainly adopt meal replacement powder, the effect is not obvious, and dampness-eliminating and spleen-tonifying medicines are inconvenient to take and have poor taste and cannot meet the requirements of users.
In view of the above, it is necessary to provide a composition for eliminating dampness and strengthening spleen to solve the above technical problems.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art.
To this end, in a first aspect of the invention, the invention proposes a composition for eliminating dampness and strengthening the spleen. According to an embodiment of the invention, the composition comprises: the red bean food comprises 1-2 parts by mass of red bean, 0.5-1.5 parts by mass of coix seed and 0.2-0.8 part by mass of poria cocos. The medicines with the effects of eliminating dampness and tonifying spleen disclosed in the prior art are numerous, and the inventor optimizes the formula through a large amount of theoretical analysis and experimental verification, changes one or more components in the formula, and obtains the formula with a less effect than the formula. In addition, the inventor finds that the components in the formula have good effects of clearing damp and tonifying spleen through a large number of experiments, and other mixture ratios are not as good as the formula.
At present, food materials/medicinal materials adopted for eliminating dampness and strengthening spleen are numerous in types, and meticulous screening finds that the food materials/medicinal materials can have the effects of eliminating dampness and strengthening spleen, and inducing diuresis and excreting dampness by compounding the red phaseolus bean, the coix seed and the poria cocos. Further, deep research and analysis show that the compounding ratio of the three components can obviously influence the drug effect, wherein the effects of clearing damp and tonifying spleen, and promoting diuresis and excreting dampness are better under the compounding ratio, so that the symptoms of digestive function reduction such as inappetence, loose stool, abdominal distension, sticky and greasy taste, diarrhea, halitosis and the like can be effectively improved, and the body is strong and energetic.
According to an embodiment of the present invention, the above composition may further comprise at least one of the following additional technical features:
according to an embodiment of the invention, the composition further comprises: chinese yam, tartary buckwheat, white hyacinth bean, red date, orange peel, hawthorn, liquorice and gardenia. According to the embodiment of the invention, the yam, the tartary buckwheat, the white hyacinth bean, the red date, the orange peel, the hawthorn, the liquorice and the gardenia which are homologous in medicine and food are selected to be compatible with the phaseolus calcaratus, the coix seed and the poria cocos, so that the effects of eliminating dampness and tonifying spleen can be further improved, and the yam, the tartary buckwheat, the white hyacinth bean, the red date, the orange peel, the hawthorn, the liquorice and the gardenia are softer in taste, fragrant in. According to an embodiment of the invention, the composition comprises: 1.2-1.8 parts of phaseolus calcaratus, 0.5-1.5 parts of coix seeds, 0.2-0.8 part of poria cocos, 0.5-1.5 parts of Chinese yam, 0.5-1.5 parts of tartary buckwheat, 0.5-1.5 parts of white hyacinth beans, 1-2 parts of red dates, 1-2 parts of orange peel, 0.1-0.3 part of hawthorn, 0.2-0.8 part of liquorice and 0.5-1.5 parts of gardenia.
According to an embodiment of the invention, the composition comprises: 1.5 parts of phaseolus calcaratus, 1 part of semen coicis, 0.5 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of cape jasmine.
In a second aspect of the invention, a method of making the composition set forth in the first aspect of the invention is set forth. According to an embodiment of the invention, the method comprises: cooking red bean, coix seed and tartary buckwheat to obtain the cooked red bean, the cooked coix seed and the cooked tartary buckwheat; pulverizing and mixing the cooked semen Phaseoli, the cooked Coicis semen and the cooked radix Et rhizoma Fagopyri Tatarici, Poria, rhizoma Dioscoreae, semen lablab album, fructus Jujubae, pericarpium Citri Tangerinae, fructus crataegi, Glycyrrhrizae radix, and fructus Gardeniae to obtain the composition. The method provided by the embodiment of the invention is simple in preparation process, easy for industrial production and convenient for popularization.
According to an embodiment of the present invention, the method may further include at least one of the following additional technical features:
according to the embodiment of the invention, the red bean and the coix seed are treated for 20-30 minutes at 80 ℃ so as to obtain the cured red bean and the cured coix seed. The heating condition can be used for curing semen Phaseoli and Coicis semen, and keeping original components as much as possible to reduce loss.
According to the embodiment of the invention, the tartary buckwheat is treated at 140 ℃ for 20-30 minutes so as to obtain the aged tartary buckwheat. The heating condition can be adopted to cure the tartary buckwheat, and the original components of the tartary buckwheat are kept as much as possible, so that the loss is reduced.
According to the embodiment of the invention, the grinding is to grind the material to 20-80 meshes. Therefore, the effective ingredients in the food materials can be fully extracted, and the extraction efficiency is improved.
In a third aspect of the invention, a beverage is provided for eliminating dampness and strengthening the spleen. According to an embodiment of the invention, the beverage comprises the composition as set forth in the first aspect of the invention. According to the beverage provided by the embodiment of the invention, natural food materials with homology of medicine and food are selected and combined according to a reasonable proportion, so that the components generate synergistic effect through medicine effect and food effect, the effect of each component is maximized, the effects of clearing damp and tonifying spleen, promoting diuresis and excreting dampness are achieved, the symptoms of digestive function reduction such as inappetence, abdominal distension, diarrhea, loose stool and edema of limbs are improved, and the beverage is especially suitable for people with spleen deficiency and fatigue, damp-heat in spleen and stomach and liver and gallbladder, unsmooth defecation and muscle fatigue. In addition, the beverage has soft mouthfeel, aromatic smell and sweet mouthfeel, and is easy to be accepted by people.
According to an embodiment of the present invention, the above beverage may further comprise at least one of the following additional technical features:
according to an embodiment of the invention, the beverage is in the form of a solid, a gel or a liquid. The beverage according to the embodiment of the invention can be a solid tea preparation, such as a tea bag, tea powder and the like, is ready to drink after being brewed and is convenient to store and carry; can also be gel semi-solid preparation, and can be drunk after being mixed with water; or the finished product liquid beverage preparation can be prepared into liquid beverage by brewing in advance, and the liquid beverage can be drunk after being opened.
In a fourth aspect of the invention, a pharmaceutical composition for eliminating dampness and strengthening the spleen is provided. According to an embodiment of the invention, the pharmaceutical composition comprises the composition set forth in the first aspect of the invention.
According to an embodiment of the present invention, the above composition may further comprise at least one of the following additional technical features:
according to an embodiment of the invention, the pharmaceutical composition is in the form of a capsule, tablet or granulate. The pharmaceutical composition according to the embodiment of the present invention may be in the form of a single dosage form, which is simple in administration manner, does not require repeated administration every day, is convenient to take, achieves maximum drug efficacy, and is easy to carry and store.
In a fifth aspect of the invention, the invention proposes the use of the composition proposed in the first aspect of the invention for the preparation of a food or a pharmaceutical product for eliminating dampness and strengthening the spleen.
According to an embodiment of the present invention, the food or pharmaceutical product is used for treating abdominal fullness and distention, anorexia, dry and sticky mouth, halitosis, loose stool, tiredness and weakness, heavy limbs and excessive phlegm.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Detailed Description
The following detailed description of the embodiments of the present invention is intended to be illustrative, and not to be construed as limiting the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
Composition comprising a metal oxide and a metal oxide
The invention provides a composition for eliminating dampness and strengthening spleen. According to an embodiment of the invention, the composition comprises: red bean, coix seed, tuckahoe, yam, tartary buckwheat, white hyacinth bean, red date, orange peel, hawthorn, liquorice and gardenia.
According to a particular embodiment of the invention, the composition comprises: 1.5 parts of phaseolus calcaratus, 1 part of semen coicis, 0.5 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of cape jasmine.
According to the embodiment of the invention, all components in the composition are homologous in medicine and food, and the effects of eliminating dampness and tonifying spleen are achieved to the maximum extent through reasonable compatibility.
According to the embodiment of the invention, the phaseolus calcaratus, the coix seed and the tuckahoe are monarch drugs; white hyacinth bean, orange peel and gardenia are used as ministerial drugs, Chinese yam, tartary buckwheat, red dates and hawthorn are used as adjuvant drugs, and liquorice is used as a conductant drug.
Small red beans:
nature and taste: gansuping for treating chronic hepatitis
Meridian tropism: spleen, heart and small intestine meridian entered
The efficacy is as follows: inducing diuresis to alleviate edema, promoting diuresis to alleviate jaundice, removing toxic substance and expelling pus
Coix seed:
nature and taste: sweet and bland in flavor and cool in nature
Meridian tropism: spleen, stomach and lung meridian entered
The efficacy is as follows: inducing diuresis, permeating moisture, invigorating spleen, relieving diarrhea, removing arthralgia, expelling pus, removing toxic substance, and resolving hard mass
Tuckahoe, poria cocos:
nature and taste: sweet, bland and neutral in nature
Meridian tropism: the heart, lung, spleen and kidney meridians
The efficacy is as follows: induce diuresis to alleviate edema, drain dampness, invigorate spleen and calm heart
Chinese yam:
nature and taste: sweet in flavor and neutral in nature
Meridian tropism: spleen, lung and kidney meridians entered
The efficacy is as follows: replenishing qi, nourishing yin, invigorating spleen, lung and kidney, arresting seminal emission and stopping leukorrhagia
Tartary buckwheat:
nature and taste: neutral in nature and sweet in taste
Meridian tropism: entering stomach and large intestine meridian
The efficacy is as follows: invigorating spleen, invigorating qi, stimulating appetite, relieving intestinal obstruction, promoting digestion, eliminating stagnation, and removing dampness
White hyacinth bean:
nature and taste: slightly warm in nature and sweet in taste
Meridian tropism: entering spleen and stomach meridians
The efficacy is as follows: invigorating spleen to eliminate dampness, regulating the middle warmer to relieve summer heat
Red dates:
nature and taste: warm in nature and sweet in taste
Meridian tropism: spleen and stomach meridian entered
The efficacy is as follows: tonifying spleen and stomach, nourishing yin and blood, nourishing heart and tranquilizing mind
Orange peel:
nature and taste: pungent and bitter in property
Meridian tropism: spleen and lung meridian entered
The efficacy is as follows: promoting qi circulation, eliminating distention, eliminating dampness, eliminating phlegm, invigorating spleen and regulating stomach
Hawthorn fruit:
nature and taste: sweet and sour with warm nature
Meridian tropism: entering liver, spleen and stomach meridians
The efficacy is as follows: promoting digestion, invigorating stomach, promoting blood circulation, removing blood stasis, expelling intestinal parasites
Licorice root:
nature and taste: neutral in nature and sweet in taste
Meridian tropism: the heart, spleen and lung meridians
The efficacy is as follows: tonifying
Gardenia:
nature and taste: bitter and cold
Meridian tropism: the three jiao channels of heart, lung, stomach and triple energizer
The efficacy is as follows: clearing heat and purging fire, cooling blood, removing toxic substance, promoting diuresis
The red bean, the coix seed and the tuckahoe have the effects of inducing diuresis and eliminating dampness, the white hyacinth bean, the orange peel and the gardenia assist the monarch drug in eliminating dampness, the Chinese yam, the tartary buckwheat, the red date and the hawthorn are adjuvant drugs with the effects of strengthening spleen and eliminating dampness, and the liquorice is a messenger drug for harmonizing drug properties. The medicinal materials are compatible and have the function of mutual coordination between warm and cool.
Preparation method
The invention provides a preparation method of the composition, according to the embodiment of the invention, the red bean and the coix seed are subjected to microwave curing (80 ℃, 20-30 min), the tartary buckwheat is fried (140 ℃, 25min), each medicinal material is separately and coarsely crushed (20-80 meshes), and the mixture is packaged.
The preparation process of the invention ensures that the prepared composition has good appearance, and the microwave heating is used for curing the phaseolus calcaratus and the coix seeds, thereby better maintaining the permeability of the internal conduction tissue and the parenchyma of each component, well maintaining the appearance and the structural integrity of the material, reducing the loss of nutrient substances and achieving better color, aroma and taste quality.
Beverage and its preparing process
The invention provides a beverage, which comprises the composition. According to the embodiment of the invention, the beverage is in the form of solid, gel or liquid, is convenient to use and has good color, shape and taste.
According to embodiments of the present invention, the beverage may further include food acceptable adjuvants such as preservatives, flavoring agents, excipients, coloring agents, sweetening agents, and the like. The food acceptable auxiliary materials include but are not limited to: water; salts or electrolytes, such as protamine sulfate, disodium hydrogen phosphate, potassium hydrogen phosphate, sodium chloride, zinc salts; lanolin; sugars such as lactose, glucose and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; gum powder; malt; gelatin; talc powder; adjuvants such as cocoa butter; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil.
Pharmaceutical composition
The invention provides a pharmaceutical composition for eliminating dampness and strengthening spleen, which comprises the above composition.
The pharmaceutical composition further comprises pharmaceutically acceptable excipients including any solvent, solid excipient, diluent, binder, disintegrant, or other liquid excipient, dispersant, flavoring or suspending agent, surfactant, isotonic agent, thickening agent, emulsifier, preservative, solid binder, glidant or lubricant, and the like, suitable for the particular target dosage form. Except insofar as any conventional adjuvant is incompatible with the pharmaceutical compositions of the invention, e.g., any adverse biological effect produced or interaction with any other component of a pharmaceutically acceptable composition in a deleterious manner, its use is contemplated by the present invention.
Substances that may serve as pharmaceutically acceptable excipients include, but are not limited to, ion exchangers; aluminum; aluminum stearate; lecithin; serum proteins, such as human serum albumin; buffer substances such as phosphates; glycine; sorbic acid; potassium sorbate; partial glyceride mixtures of saturated vegetable fatty acids; buffering agents such as magnesium hydroxide and aluminum hydroxide; glycols, such as propylene glycol and polyethylene glycol; esters such as ethyl oleate and ethyl laurate; agar; alginic acid; pyrogen-free water; isotonic salt; ringer's solution; ethanol; phosphoric acid buffer solution; and other non-toxic suitable lubricants such as sodium lauryl sulfate and magnesium stearate; a colorant; a release agent; coating the coating material; a sweetener; a flavoring agent; a fragrance; preservatives and antioxidants.
The pharmaceutical compositions of the present invention may be administered in unit dosage form. The administration dosage form can be liquid dosage form or solid dosage form. The liquid dosage forms can be true solutions, colloids, microparticles, and suspensions. Other dosage forms such as tablet, capsule, dripping pill, aerosol, pill, powder, solution, suspension, emulsion, granule, etc.
Oral tablets and capsules may contain excipients such as binding agents, for example syrup, acacia, sorbitol, tragacanth or polyvinylpyrrolidone; fillers, such as lactose, sucrose, corn starch, calcium phosphate, sorbitol, glycine; lubricants, such as magnesium stearate, talc, polyethylene glycol, silica; disintegrants, such as potato starch; or acceptable humectants such as sodium lauryl sulfate. The tablets may be coated by methods known in the art of pharmacy.
Oral liquids may be in the form of suspensions, solutions, emulsions, syrups or elixirs containing hydrated oils, or may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, sorbitol, cellulose methyl ether, glucose syrup, gelatin, hydroxyethyl cellulose, carboxymethyl cellulose, aluminium stearate gelatin, hydrogenated edible fats and oils, emulsifying agents, such as lecithin, sorbitan monooleate, acacia; or a non-aqueous carrier (which may comprise an edible oil), such as almond oil, an oil such as glycerol, ethylene glycol, or ethanol; preservatives, e.g. methyl or propyl p-hydroxybenzoate, sorbic acid. Flavoring or coloring agents may be added if desired.
The invention will now be described with reference to specific examples, which are intended to be illustrative only and not to be limiting in any way.
The prescription proportion is as follows: 1.5 parts of phaseolus calcaratus, 1 part of coix seed, 0.5 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of gardenia
The preparation process comprises the following steps: microwave-aging semen Phaseoli and Coicis semen (80 deg.C for 20-30 min), parching radix Et rhizoma Fagopyri Tatarici (140 deg.C for 25min), pulverizing each material into coarse powder (20-80 mesh), mixing, and packaging.
Example 1 proportioning Screen
In the formula, the red bean, the coix seed and the tuckahoe are used as main components, and the optimal proportion among the three is searched by changing the proportion of the three (the proportion of other components is unchanged).
Scheme 1: 1.5 parts of phaseolus calcaratus, 1 part of coix seed, 0.5 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of gardenia
Scheme 2: 1 part of phaseolus calcaratus, 2 parts of semen coicis, 1 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of cape jasmine
Scheme 3: 2 parts of phaseolus calcaratus, 1 part of coix seeds, 0.5 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth beans, 1.5 parts of red dates, 1.5 parts of orange peels, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of gardenia jasminoides ellis
Scheme 4: 1 part of phaseolus calcaratus, 1 part of semen coicis, 1 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of cape jasmine
200 patients (20-55 years old) with phlegm-dampness constitution were collected, and specifically, the patients were divided into 4 groups of 50 patients each. Respectively taking the dampness-eliminating and spleen-invigorating tea prepared by the schemes 1-4 for 8 weeks from the first group to the fourth group, and brewing one bag per person every day; the effect was then observed. The population to be excluded when collecting volunteers includes pregnant and pregnancies, lactating women; those who are allergic to the ingredients of the present compositions; patients who are participating in other drug clinical trials; the patients in the disease state are discovered through comprehensive physical examination; suspected or certain abuse of alcohol, past history of drugs, etc.
The curative effect results are as follows:
the main symptoms of phlegm-dampness constitution include: abdominal distention, inappetence, dry and sticky mouth, halitosis, loose stool, asthenia, heavy limbs, and excessive phlegm. The curative effect is evaluated by comparing the relevant symptoms of the patients before and after treatment, wherein the effect is shown as follows: most symptoms disappear after treatment; the method has the following advantages: partial symptoms are improved after treatment; and (4) invalidation: the symptoms are not obvious after treatment. Specific efficacy statistics are shown in table 1.
Table 1: effect statistical table
The results show that: the formula proportion of the scheme 1 is superior to that of other schemes.
Example 2 toxicity test
Selecting 50 SPF-grade Wistar mice (25 male mice and female mice respectively) with the weight of 20-25g, dividing the mice into 5 groups, and dividing each group of the mice with the weight of 5 male mice and female mice into 5 groups, wherein the spleen-tonifying and dampness-eliminating tea prepared according to the formula in the scheme 1 in the embodiment 1 is brewed by adopting boiled water, and the adding amount of the boiled water is calculated according to the water consumption of normal tea brewing. The dose was administered at the maximum allowable volume of mice, 0.4ml/10g, continuously drenched for 30 days. During the period of tea infusion and 1 week after the withdrawal, the white mouse was observed to have normal appetite, activity, hair color and mental status. Mice develop normally by identifying hematology, blood biochemistry, organ tissue structure, and urinary convention. All mice survive healthily without any toxic and side effect; liver function and organ tissue state were observed by dissection, and there was no difference compared with normal mice.
Experiments prove that the spleen-tonifying dampness-eliminating tea provided by the invention has no toxic or side effect.
Example 3 intervention experiment on Damp-Heat syndrome rat behaviourology
Laboratory animal
60 SPF-level Wistar rats, half male and female, with the body mass of 180-220 g, purchased from Liaoning Biotechnology Limited, and the license number of the experimental animal: SCXK (jew) 2015-:
2011007) at 21-23 deg.C and humidity of 55-58%. The clean-grade feed for experimental animals was purchased from Beijing, Australian cooperative feed Co., Ltd (license number: SCXK (Jing) 2014-0010).
Test article
Example 1 the spleen-invigorating and dampness-eliminating tea prepared by the formula of scheme 1 is brewed with boiled water, and the amount of the boiled water is calculated by the water consumption of normal tea brewing.
Animal grouping and molding method
The method comprises the following steps of randomly dividing 60 Wistar rats with half male and female into a blank group, a model group, a dampness-eliminating and spleen-tonifying tea high-dose group (a dampness-eliminating and spleen-tonifying group), a dampness-eliminating and spleen-tonifying tea medium-dose group (a dampness-eliminating and spleen-tonifying group) and a dampness-eliminating and spleen-tonifying tea low-dose group (a dampness-eliminating and spleen-tonifying group), wherein each group comprises 12 Wistar rats. The blank group is fed with common mixed feed at the temperature of 21-23 ℃ and the relative humidity of 55-58% in a room temperature environment at 8:30 a.m. every day. Preparing a rat model with spleen and stomach damp-heat syndrome, and feeding the rat model with high-sugar and high-fat feed for 10 days. 9: 00-11: 00 a.m. each day, placing the artificial climate chamber in which the temperature is 33 +/-2 ℃ and the relative humidity is 75 +/-5% for 8 days. Day 9, 8 am: and (3) performing intragastric administration 30 times, performing intragastric administration 2mL of escherichia coli for 1 time per 200g, performing intensive infection for 1 time after 24 hours, performing intragastric administration 1mL per 200g, removing, and placing in a natural environment. The damp clearing decoction is prepared by taking out the damp clearing decoction from the 4 th day on the basis of preparing a rat model with spleen and stomach damp-heat syndrome, and filling low-dose, medium-dose and high-dose damp clearing and spleen tonifying tea into a natural environment for 12 hours, wherein each 200g of damp clearing and spleen tonifying tea is filled into a stomach for 2mL, and the dose is 1 time per day.
Observation indicator and detection method
The general condition of the animals including behavior, symptoms, signs and other indicators were observed and recorded every day. After gavage for 1h on days 3 and 11 of the experiment, the behavioral performance of the animals was observed by Open-field behavioral measurement. The small animal behavioural recording and analyzing system is used for recording, and the camera system is installed and fixed above an open field for recording. A single rat is placed in the center of a square experimental box, the peripheral wall of the experimental box is a black open field, the bottom of the experimental box is divided into 25 grids with equal size, and the middle 9 grids are called as central grids. Pinching the tail of the rat and slightly placing the tail of the rat into the central grid from the root 1/3, enabling the animal to adapt in the experimental box for more than 10min before each experiment, recording the action performance of the rat within 3min, including the staying time in the central grid, the number of movement grids (which is the score of horizontal movement and the number of grids where four claws enter), the number of standing times (which is the score of vertical movement and the score of two front claws leave the ground), and removing the excrement of the animal after each measurement, wherein each measurement is only performed for 1 time.
Statistical method
The data analysis uses SPSS 20.0 statistical package to process the data statistical treatment, the measurement data is expressed by mean + -standard deviation (' x + -s), the comparison between each group uses one-factor variance analysis, the difference P <0.05 is statistical significance.
Results
Influence of dampness-eliminating and spleen-strengthening tea on behavior, symptoms and physical signs of rats
The rats in each group have no obvious abnormal behavior. Most of the rats in the model group show lassitude, sleepiness and laziness, slow reaction, fluffy hair, withered and luggy color, reduced diet, increased defecation times and sticky and greasy stool along with the lapse of time, the body temperature of the rats is obviously increased after the rats are drenched with escherichia coli, and the spleen and stomach damp-heat syndrome is well simulated. The damp-clearing spleen-tonifying tea group with high dose, medium dose and low dose also shows symptoms of activity, diet frequency reduction, sticky stool and the like before the damp-clearing spleen-tonifying tea is infused, which indicates that the molding is successful; after administration, the damp-clearing spleen-tonifying tea has the advantages that the activity times of animals in high-dose, medium-dose and low-dose groups are gradually increased, the food consumption is increased, the defecation is gradually recovered to be normal, the reaction is recovered to be normal, the fur is glossy, and the mental state is recovered to be normal. See table 2.
Table 2: influence of dampness-eliminating and spleen-strengthening tea on behavior, symptoms and physical signs of rats
The effect of dampness-eliminating and spleen-invigorating tea on the residence time of the rat central compartment is shown in table 3.
Table 3: influence of dampness-eliminating and spleen-tonifying tea on retention time of rat central compartment
Note that P x <0.01 compared to blank; p # <0.01 in comparison with the model group
The effect of dampness-eliminating and spleen-invigorating tea on the number of exercise bars in rats is shown in table 4.
TABLE 4 influence of dampness-eliminating and spleen-invigorating tea on rat exercise pattern
Note that P x <0.01 compared to blank; p # <0.01 in comparison with the model group
The effect of dampness-eliminating and spleen-invigorating tea on the number of times rats stood up is shown in table 5.
TABLE 5 influence of dampness-eliminating and spleen-invigorating tea on the erection times of rats
Note that P x <0.01 compared to blank; p # <0.01 in comparison with the model group
The experiment result shows that on the 3 rd day of the experiment, compared with the blank group, the residence time of the central lattices of each dose group of the model group and the dampness-eliminating and spleen-tonifying tea is obviously prolonged, which indicates that the space cognitive ability of rats of each dose group of the model group and the administration group is reduced; the exercise lattice number and the upright times are obviously reduced, which shows that the excitability of rats in each dosage group of the model group and the dampness-eliminating and spleen-tonifying tea is reduced, the adaptability to a new environment is weakened, the autonomous activity and the exploration behavior of the rats in a strange environment are reduced, and the success of model building is indicated. Compared with a model group, the dampness-eliminating and spleen-tonifying tea can improve the behavioral performance of rats in each dose group, and the dampness-eliminating and spleen-tonifying tea has the function of regulating the behavioral performance of the rats, which is probably related to the effects of dampness elimination, spleen strengthening and heat clearing of the medicines in the formula and the function of improving the environment in a body.
Example 4 clinical cases
1. Li Shi, male, age 44, white and greasy tongue coating, sticky and greasy mouth, loose stool, loose body, lack of strength, fat body and fat abdomen, which belongs to the phlegm-damp constitution according to the differentiation of the traditional Chinese medicine. After the dampness-eliminating and spleen-tonifying tea is taken for 6 months, clinical symptoms are fully recovered, and the physique is basically recovered to be normal.
2. Zhangzhi, female, age 22, greasy tongue coating, sticky mouth with breath, poor appetite, lassitude and hypodynamia, which is dialectical from phlegm-dampness constitution in traditional Chinese medicine. After the dampness-eliminating and spleen-tonifying tea is taken for 3 months, clinical symptoms are healed, and the physique is basically recovered to be normal.
3. Qin in, female, 38 years old, greasy tongue coating, drowsiness and hypodynamia, dreaminess, dizziness, body weight, which is the syndrome of phlegm-dampness according to the traditional Chinese medicine. After the dampness-eliminating and spleen-tonifying tea disclosed by the invention is taken for 4 months, clinical symptoms are healed, and the physique is basically recovered to be normal.
4. Lu Yi, male, age 42, white and greasy tongue coating, profuse sputum, fullness and oppression in chest and epigastrium, profuse and sticky sweat, heavy body, easy drowsiness, lethargy and sticky stool, which are distinguished by the traditional Chinese medicine to belong to phlegm-damp physique. After the dampness-eliminating and spleen-tonifying tea is taken for 4 months, clinical symptoms are healed, and the physique is basically recovered to be normal.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (10)
1. A composition for eliminating dampness and strengthening the spleen, comprising: the red bean food comprises 1-2 parts by mass of red bean, 0.5-1.5 parts by mass of coix seed and 0.2-0.8 part by mass of poria cocos.
2. The composition as claimed in claim 1, further comprising: chinese yam, tartary buckwheat, white hyacinth bean, red date, orange peel, hawthorn, liquorice and gardenia.
3. The composition as claimed in claim 1, comprising:
1.2-1.8 parts by mass of phaseolus calcaratus, 0.5-1.5 parts by mass of coix seeds, 0.2-0.8 part by mass of poria cocos, 0.5-1.5 parts by mass of Chinese yam, 0.5-1.5 parts by mass of tartary buckwheat, 0.5-1.5 parts by mass of white hyacinth beans, 1-2 parts by mass of red dates, 1-2 parts by mass of orange peel, 0.1-0.3 part by mass of hawthorn, 0.2-0.8 part by mass of liquorice and 0.5-1.5 parts by mass of gardenia;
preferably, the composition comprises:
1.5 parts of phaseolus calcaratus, 1 part of semen coicis, 0.5 part of poria cocos, 1 part of Chinese yam, 1 part of tartary buckwheat, 1 part of white hyacinth bean, 1.5 parts of red date, 1.5 parts of orange peel, 0.2 part of hawthorn, 0.5 part of liquorice and 1 part of cape jasmine.
4. A method for preparing a composition according to any one of claims 1 to 3, comprising:
cooking red bean, coix seed and tartary buckwheat to obtain the cooked red bean, the cooked coix seed and the cooked tartary buckwheat;
pulverizing and mixing the cooked adzuki beans, the cooked adlay and the cooked tartary buckwheat, poria cocos, Chinese yam, white hyacinth beans, red dates, orange peel, hawthorn, liquorice and gardenia to obtain the composition;
optionally, treating the phaseolus calcaratus and the coix seeds at 80 ℃ for 20-30 minutes so as to obtain the cured phaseolus calcaratus and the cured coix seeds;
optionally, treating the tartary buckwheat at 140 ℃ for 20-30 minutes so as to obtain the aged tartary buckwheat;
optionally, the crushing is to crush the material to 20-80 meshes.
5. A beverage for eliminating dampness and strengthening spleen, comprising the composition of any one of claims 1 to 3.
6. The beverage according to claim 5, wherein the beverage is in the form of a solid, gel or liquid.
7. A pharmaceutical composition for eliminating dampness and strengthening spleen, comprising the composition of any one of claims 1 to 3.
8. The pharmaceutical composition of claim 7, wherein the pharmaceutical composition is in the form of a capsule, tablet or granule.
9. Use of the composition of any one of claims 1 to 3 for the preparation of a food or pharmaceutical product for eliminating dampness and strengthening the spleen.
10. The use according to claim 9, wherein the food or pharmaceutical product is for the treatment of abdominal fullness and distention, loss of appetite, dry and sticky mouth, bad breath, loose stools, poor health, heavy limbs and profuse sputum.
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Cited By (3)
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| CN113575723A (en) * | 2021-07-29 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Red bean and coix seed instant tea and preparation method and application thereof |
| CN113730516A (en) * | 2021-09-26 | 2021-12-03 | 浙江嵇康健康科技有限公司 | Coix seed and poria cocos paste capable of clearing damp and tonifying spleen and application |
| CN114601165A (en) * | 2022-05-11 | 2022-06-10 | 北京中科生仪科技有限公司 | Composition for losing weight and eliminating dampness and preparation process, preparation and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113575723A (en) * | 2021-07-29 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Red bean and coix seed instant tea and preparation method and application thereof |
| CN113730516A (en) * | 2021-09-26 | 2021-12-03 | 浙江嵇康健康科技有限公司 | Coix seed and poria cocos paste capable of clearing damp and tonifying spleen and application |
| CN114601165A (en) * | 2022-05-11 | 2022-06-10 | 北京中科生仪科技有限公司 | Composition for losing weight and eliminating dampness and preparation process, preparation and application thereof |
| CN114601165B (en) * | 2022-05-11 | 2022-08-09 | 北京中科生仪科技有限公司 | Composition for losing weight and eliminating dampness and preparation process, preparation and application thereof |
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