CN1868526A - Soft capsule of active rhizoma gastrodiae, and its prepn. method - Google Patents
Soft capsule of active rhizoma gastrodiae, and its prepn. method Download PDFInfo
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- CN1868526A CN1868526A CN 200510070899 CN200510070899A CN1868526A CN 1868526 A CN1868526 A CN 1868526A CN 200510070899 CN200510070899 CN 200510070899 CN 200510070899 A CN200510070899 A CN 200510070899A CN 1868526 A CN1868526 A CN 1868526A
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Abstract
An active gastrodia soft capsule with both medical and health-care functions is composed of a core prepared from superfine active gastrodia powder extracted from gastrodia tuber, special plant oil rich in lenolenic acid (20% or more), and suspending agent, and a shell prepared from gelatin, water, glycerine and polyethanediol. Its preparing process is also disclosed.
Description
Technical field
What the present invention relates to is a kind of medicine or health food and preparation method thereof, and referring in particular to fresh Rhizoma Gastrodiae is soft capsule of active rhizoma gastrodiae of raw material and preparation method thereof.
Background technology
Rhizoma Gastrodiae has another name called rhizoma gastrodiae, DINGFENGCAO, is the tuber of the perennial parasitic herbaceous plant Rhizoma Gastrodiae of the orchid family (Castrodia elata BL.).Belong to one of traditional rare medicinal herbs of China, has good medicinal and health purpose, show through modern scientific research: Rhizoma Gastrodiae mainly contains gastrodine, gastrodin unit, also contain gastrodia elata polysaccharide, vitamin A sample material, several amino acids and mineral etc. in addition, the treatment and the health-care effect of Rhizoma Gastrodiae have the following aspects.
1, Rhizoma Gastrodiae has very significant analgesia role, the clinical all kinds of neuralgias such as vascular headache, trigeminal neuralgia, supraorbital neuralgia, sciatica that are used for the treatment of.
2, Rhizoma Gastrodiae has sedative-hypnotic effect, experiment showed, that Rhizoma Gastrodiae can reduce central nervous system's irritability, the excitement that the antagonism caffeine causes, after taking, alpha index lowers, contrast ρ＜0.05 before and after the medication makes electroencephalogram of normal adult α-Bo the sleep wave mode occur.
3, Rhizoma Gastrodiae has blood vessel dilating, increases the effect of blood vessel elasticity, can improve the brain basilar artery insufficiency, thereby reach the effect of nootropics, hypermnesis.
4, Rhizoma Gastrodiae has the effect of the alzheimer disease of preventing and treating, and this mainly is that Rhizoma Gastrodiae can reduce cerebral vascular resistance in body, and the cerebral blood flow increasing amount improves cerebral circulation.
5, Rhizoma Gastrodiae has unique effect for the symptomatic treatment of depression, at stress, emotional instability and the retardation of thinking of alleviating patient crucial effect is arranged, it is particularly effective especially " exciting type " speech that patients with depression showed to be moved situations such as obvious increase, anxiety, fear.
6, Rhizoma Gastrodiae has radiation resistance to a certain degree.
From present existing report and document, existing Rhizoma Gastrodiae soft capsule technology mainly is: 1, raw material is the Rhizoma Gastrodiae of directly purchasing from the market, just having dried beyond factory; 2, adopt Dry-crusher that Rhizoma Gastrodiae powder is broken to certain fineness; 3, Rhizoma Gastrodiae powder is mixed with a certain proportion of edible oil and other adjuvant; 4, aforesaid oil meal compound is pressed into soft capsule.Though the method for utilizing that this method is more traditional has had significant progress and raising, by modern sanitary standard and bioavailability, remains backward.Imbody in the following areas.
One, raw material adopts the Rhizoma Gastrodiae of drying.Weak point is:
When fresh gastrodia elata was processed into dried Rhizoma Gastrodiae, normally self-built bakery was dried in the open air or in the man of peasant household.At first be unclean a large amount of harmful substances and the bacterial adhesion of causing of water for cleaning at the Rhizoma Gastrodiae epidermis, when the Rhizoma Gastrodiae dehydrate, be wrapped in the densely covered ditch seam.Secondly in bake process, the harmful substance that fuel discharges adheres to and invades in the Rhizoma Gastrodiae entity.Once more in order to increase dried transparency of Rhizoma Gastrodiae and resting period, adding the sulfur Rhizoma Gastrodiae that fire-cures has been general way in the producing region, causes Rhizoma Gastrodiae further to be polluted by harmful substance.
The Rhizoma Gastrodiae epidermis is fine and close filamentary structure tissue, it is when the extraneous growth substance of filtration makes nutrient enter Rhizoma Gastrodiae tuber entity, also impurity and various harmful substance are trapped in the epidermis, add the pollution of various harmful substances in the drying course, generally can't remove, through pulverizing, again these impurity and harmful substance are brought in the Rhizoma Gastrodiae powder.
In addition, the high temperature steaming that Rhizoma Gastrodiae must carry out before oven dry causes in the Rhizoma Gastrodiae active substance partly to decompose and runs off and the biological activity reduction.
Two, adopt Dry-crusher that dried Rhizoma Gastrodiae tuber is pulverized.Weak point is:
Dried Rhizoma Gastrodiae stem tuber powder is broken to 100-500 purpose fineness, needs at least through the above pulverizing of secondary.With mill stiff material is pulverized and to be produced high localized hyperthermia, cause the part of Rhizoma Gastrodiae active substance to be decomposed again, reduce biological activity, and further increased the content of heavy metal in the powder.Crushing process is pulverized utility, useless material, harmful substance together and is made into powder, can not extract utility, removes useless material and harmful substance.
Three, the general edible oil that adds as adjuvant mainly is in order to help suppressing soft capsule on technology, human body not to be had treatment and health-care effect substantially.
Four, sterilization is not thorough.Only see with ethanol in the data document Rhizoma Gastrodiae powder is carried out sterilization treatment, edible oil and other adjuvant that adds do not carried out sterilization treatment.
Summary of the invention
The object of the present invention is to provide and a kind ofly utilize fresh Rhizoma Gastrodiae to be soft capsule of active rhizoma gastrodiae of raw material and preparation method thereof.
The technical solution used in the present invention is:
At first will newly gather, the fresh Rhizoma Gastrodiae tuber of moisture content between 70%-85% clean and machinery cleans bonded mode with artificial, adopts that source of clean water is cleaned, sterilization for the first time.To clean fresh gastrodia elata later with disintegrating machine and wear into slurry, the solid fineness is greatly between the 60-150 order.Reuse colloid mill or other slurry grinders will further grind through the slurry of previous step preliminary grinding, the solid fineness that obtains is between the 150-400 order, at this moment, because the Rhizoma Gastrodiae epidermis is different with the real intravital active substance property and structure of crude fibre and Rhizoma Gastrodiae, be on the different fineness levels, it Cortex Cannabis and coarse-fibred fineness almost concentrate in 200 orders, with filter screen press type mechanical filter or the filtering method of centrifugal mechanical, the Rhizoma Gastrodiae epidermis is separated with active substance with crude fibre, can remove most of harmful substance and useless material substantially.Above-mentioned filtering technique also can promptly carry out after the corase grind for the first time, but can cause the loss of small part active substance in the Rhizoma Gastrodiae entity.
With the Rhizoma Gastrodiae slurry after filtering through cold drying or moment spray drying get the smart powder of Rhizoma Gastrodiae, the smart powder of Rhizoma Gastrodiae is carried out micronizing again with the low temperature supersonic jet mill gets the Rhizoma Gastrodiae ultra micro essence powder (moisture content is controlled in 8%) that the 600-2500 purpose accounts for fresh Rhizoma Gastrodiae weight 10-13%.The smart powder of this Rhizoma Gastrodiae ultra micro is owing to adopt wet grinding and the pulverizing of low temperature supersonic airstream, and processing temperature is extremely low, and the biological activity of active substance has obtained preserving to greatest extent in the Rhizoma Gastrodiae.Test through the finished product that this law is made, the content that the result shows wherein lead, arsenic, hydrargyrum before filter above national standard, be lower than 1/20th of national standard after reducing to filtration.Since slurry be adopt cold drying or moment spray drying, thereby guaranteed that to greatest extent wherein gastrodine, each seed amino acid and polysaccharide isoreactivity material are not decomposed in drying.The smart powder of above gained active Gastrodia elata ultra micro is added a certain proportion of special vegetable oil and adjuvant, be pressed into the soft capsule of 500-1000mg by known soft capsule production equipment and technology.
The present invention is implemented by following concrete scheme.
A kind of soft capsule of active rhizoma gastrodiae of the present invention comprises soft capsule content and soft capsule material, and it is made of following component and weight proportion:
By weight percentage
The capsule content is made up of 1 part in the smart powder of active Gastrodia elata ultra micro, special vegetable oil 1-15 part, suspending agent 0-5 part;
The capsule material is made up of 100 parts in gelatin, water 80-120 part, glycerol 30-60 part, Polyethylene Glycol 0.01-10 part.
The weight proportion of each component can be preferably:
By weight percentage
The capsule content is made up of 1 part in the smart powder of active Gastrodia elata ultra micro, special vegetable oil 1.5-10 part, suspending agent 0.02-2 part;
The capsule material is made up of 100 parts in gelatin, water 85-110 part, glycerol 35-55 part, Polyethylene Glycol 0.025-5 part.
Weight proportion the best of each component is:
By weight percentage
The capsule content is made up of 1 part in the smart powder of active Gastrodia elata ultra micro, special vegetable oil 2-4 part, suspending agent 0.025-1 part;
The capsule material is made up of 100 parts in gelatin, water 90-100 part, glycerol 40-50 part, Polyethylene Glycol 0.03-3 part.
The soft capsule of active rhizoma gastrodiae that mentioned component constitutes, described special vegetable oil are refine Semen Lini oil, Oleum Perillae, seed of Radix Oenotherae erythrosepalae oil, Fructrs Hippophae seed oil, Semen Juglandis oil, the seed of black currant oil of linolenic acid content more than 20% during fatty acid is formed; Described suspending agent is Polyethylene Glycol, lecithin, sucrose fatty acid ester.
The soft capsule of producing is used
60The gamma-rays of Co carries out irradiation sterilization, exposure dose by relevant national standard carry out ([the defending medicine to send out＜1997〉No. 38 literary compositions] that on March 20th, 1997, Ministry of Health of the People's Republic of China signed and issued "
60Co irradiation Chinese medicine sterilizing dose standard ").
The present invention compared with prior art has the following advantages:
One, fineness of powder is thinner, more helps absorption of human body;
Two, preserved more active substance, its bioavailability is got a greater increase;
Three, remove harmful substance and useless material, the particularly content of lead, arsenic, hydrargyrum well below national food hygienic standard, solved the problem that general content of beary metal exceeds standard in the present sky gunny products;
Four, sterilization is thorough, and major ingredient adjuvant and capsule material are all thoroughly sterilized;
Five, the present invention has added especially that to be rich in linolenic special vegetable oil be adjuvant, has not only satisfied the demand of soft capsule pressing process, and the treatment and health function to body of Rhizoma Gastrodiae is further strengthened and expands.
Linolenic acid is an essential fatty acid, its effective ingredient alpha-linolenic acid, gamma-Linolenic acid, and human body self can not synthesize, and must absorb from the external world." two acid " is described as vital principle---the vitaminF of 21 century by the physician, to eliminating the modern because of the superfluous healthy hidden danger that causes of the saturated fat of generally taking in, the sickness rate that reduces cardiovascular and cerebrovascular disease has very significant effect.Show that according to studying data at home and abroad the basic effect of linolenic acid shows as: 1, blood lipid regulation, reduction hypertension; 2, improve intelligence and vision; 3, relieving constipation protects the liver; 4, antioxidation, inhibition aging; 5, suppress thrombus disease, prevention myocardial infarction and cerebral infarction; 6, the generation of anticancer and transfer; 7, promote insulin secretion, prolong hypoglycemic effect, suppress complication; 8, suppress irritated, antiinflammatory action.9, suppress ulcer and gastrorrhagia; 10, human body immunity improving ability;
The specific embodiment:
Embodiment 1
Get 1 part in the smart powder of active Gastrodia elata ultra micro, 2 parts of compositions of refine Semen Juglandis oil capsule content, carry out homogenizing with high speed shear formula homogenizer and handle stand-by;
Get 100 parts in gelatin, 90 parts in water, 40 parts of glycerol, 0.03 part of composition of Polyethylene Glycol capsule material, set aside for use after the heating in water bath dissolving stirs;
The two is put into the soft capsule production equipment be pressed into soft capsule, the capsule content accounts for 60% of weight in the soft capsule of making, and the capsule material accounts for 40% of weight.Soft capsule after the dried packing is used
60The gamma-rays of Co is assisted according to sterilization treatment.
Embodiment 2
Get 1 part in the smart powder of active Gastrodia elata ultra micro, 4 parts of refine Semen Lini oil, 0.02 part of composition of Polyethylene Glycol capsule content, carry out homogenizing and handle stand-by;
Get 100 parts in gelatin, 95 parts in water, 42 parts of glycerol, 0.05 part of composition of Polyethylene Glycol capsule material, set aside for use after the heating in water bath dissolving stirs;
The two is put into the soft capsule production equipment be pressed into soft capsule, the capsule content accounts for 60% of weight in the soft capsule of making, and the capsule material accounts for 40% of weight.Soft capsule after the dried packing is used
60The gamma-rays of Co is assisted according to sterilization treatment.
Embodiment 3
Get 1 part in the smart powder of active Gastrodia elata ultra micro, 3 parts of refine Oleum Perillae, 0.03 part of composition of lecithin capsule content, carry out homogenizing and handle stand-by;
Get 100 parts in gelatin, 100 parts in water, 30 parts of glycerol, 0.5 part of composition of Polyethylene Glycol capsule material, set aside for use after the heating in water bath dissolving stirs;
The two is put into the soft capsule production equipment be pressed into soft capsule, the capsule content accounts for 60% of weight in the soft capsule of making, and the capsule material accounts for 40% of weight.Soft capsule after the dried packing is used
60The gamma-rays of Co is assisted according to sterilization treatment.
Embodiment 4
Get 1 part in the smart powder of active Gastrodia elata ultra micro, 2 parts of refine seed of Radix Oenotherae erythrosepalae oil, 1 part of composition of lecithin capsule content, carry out homogenizing and handle stand-by;
Get 100 parts in gelatin, 92 parts in water, 35 parts of glycerol, 1 part of composition of Polyethylene Glycol capsule material, set aside for use after the heating in water bath dissolving stirs;
The two is put into the soft capsule production equipment be pressed into soft capsule, the capsule content accounts for 60% of weight in the soft capsule of making, and the capsule material accounts for 40% of weight.Soft capsule after the dried packing is used
60The gamma-rays of Co is assisted according to sterilization treatment.
Embodiment 5
Get 1 part in the smart powder of active Gastrodia elata ultra micro, 2.5 parts of refine Fructrs Hippophae seed oil, 0.025 part of composition of sucrose fatty acid ester capsule content, carry out homogenizing and handle stand-by;
Get 100 parts in gelatin, water % part, 32 parts of glycerol, 1.5 parts of compositions of Polyethylene Glycol capsule material, set aside for use after the heating in water bath dissolving stirs;
The two is put into the soft capsule production equipment be pressed into soft capsule, the capsule content accounts for 60% of weight in the soft capsule of making, and the capsule material accounts for 40% of weight.Soft capsule after the dried packing is used
60The gamma-rays of Co is assisted according to sterilization treatment.
Embodiment 6
Get 1 part in the smart powder of active Gastrodia elata ultra micro, 2.2 parts of refine seed of black currant oil, 0.02 part of composition of sucrose fatty acid ester capsule content, carry out homogenizing and handle stand-by;
Get 100 parts in gelatin, 98 parts in water, 38 parts of glycerol, 1.5 parts of compositions of Polyethylene Glycol capsule material, set aside for use after the heating in water bath dissolving stirs;
The two is put into the soft capsule production equipment be pressed into soft capsule, the capsule content accounts for 60% of weight in the soft capsule of making, and the capsule material accounts for 40% of weight.Soft capsule after the dried packing is used
60The gamma-rays of Co is assisted according to sterilization treatment.
Claims (6)
1, a kind of soft capsule of active rhizoma gastrodiae is made up of capsule content 60% and capsule material 40%, it is characterized in that they are made of following component and weight proportion:
The capsule content is made up of 1 part in the smart powder of active Gastrodia elata ultra micro, special vegetable oil 1-15 part, suspending agent 0-5 part;
The capsule material is made up of 100 parts in gelatin, water 80-120 part, glycerol 30-60 part, Polyethylene Glycol 0.01-10 part.
2, as claims 1 described soft capsule of active rhizoma gastrodiae, it is characterized in that the weight proportion of each component is preferably:
The capsule content is formed by 1 part in the smart powder of active Gastrodia elata ultra micro, special vegetable oil 1.5-10 part, suspending agent 0.02-2 part;
The capsule material is formed by 100 parts in gelatin, water 85-110 part, glycerol 35-55 part, Polyethylene Glycol 0.025-5 part.
3,, it is characterized in that weight proportion the best of each component is as claims 1 described soft capsule of active rhizoma gastrodiae:
The capsule content is formed by 1 part in the smart powder of active Gastrodia elata ultra micro, special vegetable oil 2-4 part, suspending agent 0.025-0.1 part;
The capsule material is formed by 100 parts in gelatin, water 90-100 part, glycerol 40-50 part, Polyethylene Glycol 0.03-3 part.
4, be characterised in that as claims 1 or 2 or 3 described soft capsule of active rhizoma gastrodiae: the smart powder of described active Gastrodia elata ultra micro is made a living Rhizoma Gastrodiae behind the defibrination filter and remove residue, cold drying or moment spray drying gained powder, again through the low temperature supersonic airstream pulverize 600-2500 order ultra-micro powder.
5, be characterised in that as claims 1 or 2 or 3 described soft capsule of active rhizoma gastrodiae: described special vegetable oil is refine Semen Lini oil, Oleum Perillae, seed of Radix Oenotherae erythrosepalae oil, Fructrs Hippophae seed oil, Semen Juglandis oil, the seed of black currant oil of linolenic acid content in the fatty acid 〉=20%.
6, be characterised in that as claims 1 or 2 or 3 described soft capsule of active rhizoma gastrodiae: described suspending agent is Polyethylene Glycol, lecithin, sucrose fatty acid ester.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510070899 CN1868526A (en) | 2005-05-23 | 2005-05-23 | Soft capsule of active rhizoma gastrodiae, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510070899 CN1868526A (en) | 2005-05-23 | 2005-05-23 | Soft capsule of active rhizoma gastrodiae, and its prepn. method |
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| CN1868526A true CN1868526A (en) | 2006-11-29 |
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| CN 200510070899 Pending CN1868526A (en) | 2005-05-23 | 2005-05-23 | Soft capsule of active rhizoma gastrodiae, and its prepn. method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961378A (en) * | 2010-07-01 | 2011-02-02 | 高原圣果沙棘制品有限公司 | Formula of health-care product for resisting oxidation and enhancing immunity |
| CN101972412A (en) * | 2010-10-15 | 2011-02-16 | 陕西新药技术开发中心 | Composition of tall gastrodia tuber and lecithin, and preparation method thereof |
| CN102716348A (en) * | 2012-07-04 | 2012-10-10 | 上海玉成干燥设备有限公司 | Method for preparing superfine rhizoma gastrodiae powder by vacuum freeze drying |
| CN102940783A (en) * | 2012-09-13 | 2013-02-27 | 刘祥义 | Active fresh Gastrodia elata superfine powder and preparation method thereof |
-
2005
- 2005-05-23 CN CN 200510070899 patent/CN1868526A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961378A (en) * | 2010-07-01 | 2011-02-02 | 高原圣果沙棘制品有限公司 | Formula of health-care product for resisting oxidation and enhancing immunity |
| CN101972412A (en) * | 2010-10-15 | 2011-02-16 | 陕西新药技术开发中心 | Composition of tall gastrodia tuber and lecithin, and preparation method thereof |
| CN101972412B (en) * | 2010-10-15 | 2012-06-27 | 陕西新药技术开发中心 | Composition of tall gastrodia tuber and lecithin, and preparation method thereof |
| CN102716348A (en) * | 2012-07-04 | 2012-10-10 | 上海玉成干燥设备有限公司 | Method for preparing superfine rhizoma gastrodiae powder by vacuum freeze drying |
| CN102716348B (en) * | 2012-07-04 | 2014-07-30 | 上海玉成干燥设备有限公司 | Method for preparing superfine rhizoma gastrodiae powder by vacuum freeze drying |
| CN102940783A (en) * | 2012-09-13 | 2013-02-27 | 刘祥义 | Active fresh Gastrodia elata superfine powder and preparation method thereof |
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Open date: 20061129 |