CN109010579A - A kind of antioxidant and anti-aging Chinese traditional compound medicine and preparation method thereof - Google Patents
A kind of antioxidant and anti-aging Chinese traditional compound medicine and preparation method thereof Download PDFInfo
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- CN109010579A CN109010579A CN201811050081.0A CN201811050081A CN109010579A CN 109010579 A CN109010579 A CN 109010579A CN 201811050081 A CN201811050081 A CN 201811050081A CN 109010579 A CN109010579 A CN 109010579A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention relates to a kind of antioxidant and anti-aging Chinese traditional compound medicines and preparation method thereof, it is characterised in that including following weight parts raw material: 20-38 parts of ginkgo leaf, 20-35 parts of garlic, 18-33 parts of fructus lycii, 16-28 parts of Radix Astragali, 15-24 parts of ginseng, 12-18 parts of the fleece-flower root, 10-16 parts of root of kirilow rhodiola, 5-10 parts of pilose antler.Above-mentioned formula can be made into soft capsule.Chinese traditional compound medicine provided by the present invention, it proves to can be improved body hepatocuprein (SOD) content by taking test to mouse aging and crowd, Serum MDA (MDA) content is reduced, has the function of good removing free radical, anti-oxidant, anti-aging.
Description
Technical field
The present invention relates to herbal mixture field more particularly to a kind of antioxidant and anti-aging Chinese traditional compound medicine and its preparations
Method.
Background technique
Free radical is the metabolite of human normal, have in human body under normal circumstances remove free radical enzyme system (SOD,
GSH-PX, CAT) and non-enzyme system (vitamin C, vitamin E, uric acid, ceruloplasmin), it is at and constantly generates and disappear
In the dynamic equilibrium removed.But because of the factors body such as age, disease, wound, environmental pollution, bad life style and chemicals
Excessive living radical can be generated, excessive free radical can draw the oxidation of large biological molecule such as protein, lipid and nucleic acid etc.
Damage is denaturalized body internal protein, and nucleic acid metabolism disorder, biological enzyme destroys, and hormone is oxidized, and leads to film loss function,
Aged pigment bulk deposition in lysosome generates a large amount of lipid peroxide (LPO) and malonaldehyde (MDA), makes each internal organs of body
Damage and function are lost, so as to cause body aging and a variety of chronic diseases.
Traditional Chinese medicine has practical experience abundant in terms of alleviating and treating because aoxidizing caused chronic disease.But
It is that there is also shortcomings in terms of efficacy and safety for existing product.
Summary of the invention
The object of the invention is to for overcome the deficiencies in the prior art and defect, provide it is a kind of with integration of drinking and medicinal herbs article or
Health care food materials are primary raw material, take safety, have anti-oxidant, deferring senility antioxidant and anti-aging herbal mixture system
Agent.
Object of the present invention is to what is be achieved through the following technical solutions:
This antioxidant and anti-aging Chinese traditional compound medicine, it is characterised in that: contain the original of following parts by weight in the Chinese materia medica preparation
Material: 20-38 parts of ginkgo leaf, 20-35 parts of garlic, 18-33 parts of fructus lycii, 16-28 parts of Radix Astragali, 15-24 parts of ginseng, fleece-flower root 12-
18 parts, 10-16 parts of root of kirilow rhodiola, 5-10 parts of pilose antler.
It is a further object to provide a kind of preparation method of antioxidant and anti-aging Chinese traditional compound medicine, features
It is: contains the raw material of following parts by weight: 20-38 parts of ginkgo leaf, 20-35 parts of garlic, fructus lycii 18-33 in the Chinese materia medica preparation
Part, 16-28 parts of Radix Astragali, 15-24 parts of ginseng, 12-18 parts of the fleece-flower root, 10-16 parts of root of kirilow rhodiola, 5-10 parts of pilose antler, including following works
Skill step:
(1) fructus lycii, Radix Astragali, ginseng, the fleece-flower root, pilose antler are weighed by weight, are ground into powder, after soaking in water 30 minutes,
80-90 DEG C is extracted twice, wherein once pressing material-water ratio 1:20 extracting in water 2 hours, another time by material-water ratio 1:10 extracting in water 1
Hour, it filters to get filtrate, merging filtrate is concentrated under reduced pressure into thick paste, is dried in vacuo at 55 DEG C -60 DEG C, is ground into powder, mistake
100 meshes obtain powders A, spare；
(2) ginkgo leaf, garlic, root of kirilow rhodiola are weighed by weight, is ground into powder, and after adding 70% ethyl alcohol to impregnate 30 minutes, 55 DEG C super
Sound extracts twice, supersonic frequency 10-15kHz, wherein once pressing solid-liquid ratio 1:15(m/v) plus 60 points of 70% EtOH Sonicate extraction
It is clock, another time to press solid-liquid ratio 1:10(m/v) plus 70% EtOH Sonicate extract 60 minutes, filtration, merging filtrate recycles ethyl alcohol, decompression
It is concentrated into thick paste, obtains alcohol extracting thick paste, it is spare；The dregs of a decoction after taking alcohol extracting, add water to cook it is secondary, wherein one time 10 times of dosing slag amount
Water decocts 60 minutes, 5 times of amount water of another secondary dosing slag, decocts 30 minutes, merges decocting liquid, filters to get filtrate, and is concentrated under reduced pressure
It to thick paste, obtains water and mentions thick paste, merge with above-mentioned alcohol extracting thick paste, be dried in vacuo, be crushed into powder at 55 DEG C -60 DEG C after mixing evenly
End sieves with 100 mesh sieve, and obtains powder B, spare；
(3) powders A prepared by step (1) and powder B prepared by step (2) are uniformly mixed, pharmaceutic adjuvant and plant is added
Object oil, is made soft capsule preparation.
Compared with prior art, the present invention having the advantage that
(1) raw material used in the present invention is all integration of drinking and medicinal herbs article or healthy food material, takes safety, can be used as food or
Health food uses.
(2) present invention takes test through zoopery and crowd and proves, for unsaturated fatty acid peroxidating on biomembrane
Caused damage has significant protective effect, has and significant resists and remove body free radical, anti-oxidant, anti-aging
Effect.
Therapeutic mechanism of the invention:
Ginkgo: ginkgo biloba p.e (EGb) mainly contains the physiological activators such as flavonoid glycosides and ginkgolides class.It is wherein yellow
Contain reproducibility hydroxyl functional groups in ketone molecule, terminates free radical chain and playing hydrogen donors to free radical
Formula reaction, directly removing O2-, OH-, H2O2, alkanes free radical and Lipid Free Radicals, thus prevent and inhibit radical reaction and
Peroxidatic reaction of lipid inhibits Serum LPO Levels (LPO) and its metabolite malonaldehyde (MDA), conjugated diene isoreactivity
The generation of toxicant.Meanwhile flavonoids may also participate in adjusting and improve superoxide dismutase (SOD), catalase
(CAT), the activity of the antioxidases such as glutathione peroxidase (GSH-Px).Therefore, EGb can be considered a kind of freedom of wide spectrum
Base scavenger.
Garlic: its extract allicin not only plays the role of antitumor, antibacterial, anti-bolt thrombolysis, prevents artery sclerosis, also
There are free radical resisting, protection brain cell.O2-, OH- can be effectively removed, GSH-Px and CAT activity also can be improved, reduce LPO
It generates, it is horizontal to reduce by one Reperfu- sion serum MDA of Transient Forebrain Ischemia.
Fructus lycii: the anti-oxidation active substances such as fructus lycii carrotene rich in, vitamin E, selenium and flavonoids resist
Oxidation is the coefficient result of a variety of anti-oxidation active substances contained by it.Polysaccharides is also important in fructus lycii
Antioxidant content can significantly reduce experimental animal Splenic vessel LPO content, and have to lipid anti-oxidative damage caused by CCl4 bright
Aobvious protective effect.Fructus lycii also has adjusting body's immunity, can effectively inhibit tumour growth and cell mutation, has kidney tonifying
Strengthening the essence nourishes the liver to improve visual acuity, and delays senescence, and anti-fatty liver adjusts blood lipid and blood glucose, promotes the effect of hematopoiesis function etc..
Radix Astragali: modern pharmacology research confirm Radix Astragali have free radical resisting damage function, activity extract ingredient to H2O2,
O2-, ultraviolet light radiation-induced membrane lipid peroxidatio have stronger inhibition effect.Radix Astragali can also be such that SOD activity increases, to freedom
The generation and removing of base have two-way function.
Ginseng: ginsenoside can inhibit peroxidatic reaction of lipid caused by many factors, increase SOD activity, and can have
Remove O in effect ground2-And OH-, experimental myocardial infarction range can be made to reduce, mitigate myocardial reperfusion injury;Cerebral blood flow (CBF) can be increased,
Mitigate brain edema ultrastructure damage, reduces the death rate;Person in middle and old age's Mouse Liver and Serum LPO content can be also significantly reduced, is inhibited
Person in middle and old age's animal lipid peroxidation reduces lipofuscin deposition.
The fleece-flower root: experiments have shown that Aged Mice Blood SOD Activity can be improved in fleece-flower root water decoction, ether extract can be obvious
Inhibit the activity of MAO-B in liver and brain.The fleece-flower root can also inhibit rat liver microsomal lipid peroxidation to react.
Root of kirilow rhodiola: root of kirilow rhodiola is widely used in senile heart failure, antifatigue, raising physical strength and mental labour function, is a kind of
SOD and GSH-Px activity in brain tissue can be improved in stronger antioxidant, effective component rhodiola essence, reduces LPO and is formed.
Pilose antler: experiments have shown that pilose antler water extract and principle active component phosphatide, total rouge and contained hypoxanthine
Significantly inhibit Aged Mice intracerebral MAO-B activity, hence it is evident that increase brain serotonin and DOPAMINE CONTENT IN RABBIT, enhancement of SOD activity reduces
MDA is horizontal, increases the RNA and protein content of brain tissue, has significant protective effect to experiment mice learning memory disorder.
Specific embodiment
Combined with specific embodiments below, the present invention is described in further detail, but embodiments of the present invention are simultaneously
The range that not limited to this embodiment indicates.
Embodiment 1:
The preparation method of this antioxidant and anti-aging Chinese traditional compound medicine, it is characterised in that: containing following in the Chinese materia medica preparation
The raw material of parts by weight: 30 parts of ginkgo leaf, 28 parts of garlic, 20 parts of fructus lycii, 28 parts of Radix Astragali, 20 parts of ginseng, 15 parts of the fleece-flower root, red scape
It 10 parts, 8 parts of pilose antler.
The specific step of preparation process of this antioxidant and anti-aging Chinese traditional compound medicine is as follows:
(1) fructus lycii, Radix Astragali, ginseng, the fleece-flower root, pilose antler are weighed by weight, are ground into powder, after soaking in water 30 minutes,
80-90 DEG C is extracted twice, wherein once pressing material-water ratio 1:20 extracting in water 2 hours, another time by material-water ratio 1:10 extracting in water 1
Hour, it filters to get filtrate, merging filtrate is concentrated under reduced pressure into thick paste, is dried in vacuo at 55 DEG C -60 DEG C, is ground into powder, mistake
100 meshes obtain powders A, spare；
(2) ginkgo leaf, garlic, root of kirilow rhodiola are weighed by weight, is ground into powder, and after adding 70% ethyl alcohol to impregnate 30 minutes, 55 DEG C super
Sound extracts twice, supersonic frequency 10-15kHz, wherein once pressing solid-liquid ratio 1:15(m/v) plus 60 points of 70% EtOH Sonicate extraction
It is clock, another time to press solid-liquid ratio 1:10(m/v) plus 70% EtOH Sonicate extract 60 minutes, filtration, merging filtrate recycles ethyl alcohol, decompression
It is concentrated into thick paste, obtains alcohol extracting thick paste, it is spare；The dregs of a decoction after taking alcohol extracting, add water to cook it is secondary, wherein one time 10 times of dosing slag amount
Water decocts 60 minutes, 5 times of amount water of another secondary dosing slag, decocts 30 minutes, merges decocting liquid, filters to get filtrate, and is concentrated under reduced pressure
It to thick paste, obtains water and mentions thick paste, merge with above-mentioned alcohol extracting thick paste, be dried in vacuo, be crushed into powder at 55 DEG C -60 DEG C after mixing evenly
End sieves with 100 mesh sieve, and obtains powder B, spare；
(3) powders A prepared by step (1) and powder B prepared by step (2) are uniformly mixed, pharmaceutic adjuvant and plant is added
Object oil, is made soft capsule preparation, average every 400mg.
Instructions of taking and dosage: it is oral, adult daily 3 times, 3 tablets each time.
Embodiment 2:
The preparation method of this antioxidant and anti-aging Chinese traditional compound medicine, it is characterised in that: containing following in the Chinese materia medica preparation
The raw material of parts by weight: 20 parts of ginkgo leaf, 35 parts of garlic, 33 parts of fructus lycii, 16 parts of Radix Astragali, 24 parts of ginseng, 12 parts of the fleece-flower root, red scape
It 13 parts, 10 parts of pilose antler.
The specific step of preparation process of this antioxidant and anti-aging Chinese traditional compound medicine is as follows:
(1) fructus lycii, Radix Astragali, ginseng, the fleece-flower root, pilose antler are weighed by weight, are ground into powder, after soaking in water 30 minutes,
80-90 DEG C is extracted twice, wherein once pressing material-water ratio 1:20 extracting in water 2 hours, another time by material-water ratio 1:10 extracting in water 1
Hour, it filters to get filtrate, merging filtrate is concentrated under reduced pressure into thick paste, is dried in vacuo at 55 DEG C -60 DEG C, is ground into powder, mistake
100 meshes obtain powders A, spare；
(2) ginkgo leaf, garlic, root of kirilow rhodiola are weighed by weight, is ground into powder, and after adding 70% ethyl alcohol to impregnate 30 minutes, 55 DEG C super
Sound extracts twice, supersonic frequency 10-15kHz, wherein once pressing solid-liquid ratio 1:15(m/v) plus 60 points of 70% EtOH Sonicate extraction
It is clock, another time to press solid-liquid ratio 1:10(m/v) plus 70% EtOH Sonicate extract 60 minutes, filtration, merging filtrate recycles ethyl alcohol, decompression
It is concentrated into thick paste, obtains alcohol extracting thick paste, it is spare；The dregs of a decoction after taking alcohol extracting, add water to cook it is secondary, wherein one time 10 times of dosing slag amount
Water decocts 60 minutes, 5 times of amount water of another secondary dosing slag, decocts 30 minutes, merges decocting liquid, filters to get filtrate, and is concentrated under reduced pressure
It to thick paste, obtains water and mentions thick paste, merge with above-mentioned alcohol extracting thick paste, be dried in vacuo, be crushed into powder at 55 DEG C -60 DEG C after mixing evenly
End sieves with 100 mesh sieve, and obtains powder B, spare；
(3) powders A prepared by step (1) and powder B prepared by step (2) are uniformly mixed, pharmaceutic adjuvant and plant is added
Object oil, is made soft capsule preparation, average every 400mg.
Instructions of taking and dosage: it is oral, adult daily 3 times, 3 tablets each time.
Embodiment 3:
The preparation method of this antioxidant and anti-aging Chinese traditional compound medicine, it is characterised in that: containing following in the Chinese materia medica preparation
The raw material of parts by weight: 38 parts of ginkgo leaf, 20 parts of garlic, 26 parts of fructus lycii, 22 parts of Radix Astragali, 15 parts of ginseng, 18 parts of the fleece-flower root, red scape
It 16 parts, 5 parts of pilose antler.
The specific step of preparation process of this antioxidant and anti-aging Chinese traditional compound medicine is as follows:
(1) fructus lycii, Radix Astragali, ginseng, the fleece-flower root, pilose antler are weighed by weight, are ground into powder, after soaking in water 30 minutes,
80-90 DEG C is extracted twice, wherein once pressing material-water ratio 1:20 extracting in water 2 hours, another time by material-water ratio 1:10 extracting in water 1
Hour, it filters to get filtrate, merging filtrate is concentrated under reduced pressure into thick paste, is dried in vacuo at 55 DEG C -60 DEG C, is ground into powder, mistake
100 meshes obtain powders A, spare；
(2) ginkgo leaf, garlic, root of kirilow rhodiola are weighed by weight, is ground into powder, and after adding 70% ethyl alcohol to impregnate 30 minutes, 55 DEG C super
Sound extracts twice, supersonic frequency 10-15kHz, wherein once pressing solid-liquid ratio 1:15(m/v) plus 60 points of 70% EtOH Sonicate extraction
It is clock, another time to press solid-liquid ratio 1:10(m/v) plus 70% EtOH Sonicate extract 60 minutes, filtration, merging filtrate recycles ethyl alcohol, decompression
It is concentrated into thick paste, obtains alcohol extracting thick paste, it is spare；The dregs of a decoction after taking alcohol extracting, add water to cook it is secondary, wherein one time 10 times of dosing slag amount
Water decocts 60 minutes, 5 times of amount water of another secondary dosing slag, decocts 30 minutes, merges decocting liquid, filters to get filtrate, and is concentrated under reduced pressure
It to thick paste, obtains water and mentions thick paste, merge with above-mentioned alcohol extracting thick paste, be dried in vacuo, be crushed into powder at 55 DEG C -60 DEG C after mixing evenly
End sieves with 100 mesh sieve, and obtains powder B, spare；
(3) powders A prepared by step (1) and powder B prepared by step (2) are uniformly mixed, pharmaceutic adjuvant and plant is added
Object oil, is made soft capsule preparation, average every 400mg.
Instructions of taking and dosage: it is oral, adult daily 3 times, 3 tablets each time.
To confirm that antioxidant and anti-aging Chinese traditional compound medicine of the present invention has effective therapeutic effect, a series of examinations have been carried out
Test research.
The animal experiment effect of the anti-oxidation function of Chinese traditional compound medicine of the present invention is as follows:
1, materials and methods
Animal modeling and grouping: selection female KM mouse 50,18-22 grams of weight, normal control mice 10, aging model
Mouse 40.Exhausted mining areas is randomly divided into the large, medium and small dosage group of aging model group, invention formulation, every group 10.
Exhausted mining areas is subcutaneously injected D- galactolipin 1 time daily, and dosage 120mg/kg.bw continuous 8 weeks, builds mice aging model.
Administration: injection of d-galactose starts to give test medicine after 2 weeks, and successive administration 6 weeks, once a day, system of the present invention
The agent large dosage group resulting capsule 's content 1.2g/kg.bw of daily stomach-filling embodiment 1, invention formulation middle dose group fill daily
The resulting capsule 's content 0.6g/kg.bw of stomach embodiment 1, the resulting glue of the daily stomach-filling embodiment 1 of invention formulation small dose group
Intracapsular tolerant 0.3g/kg.bw, Normal group daily stomach-filling such as give at the weight distilled water.
2, Antioxidant Indexes detect:
The 2nd day after drug withdrawal, femoral artery takes blood, separates serum.The kit of Bioengineering Research Institute's offer is provided using Nanjing
Serum total number born (SOD) vigor (hydroxylamine assay) and malonaldehyde (MDA) content (TBA method) are detected respectively.
3, efficacy result:
It is shown in Table 1, table 2:
From table 1 it follows that the total SOD activity of the serum of the large, medium and small dosage group of invention formulation be significantly higher than model group (P <
0.05), reach Normal group level, illustrate that Chinese traditional compound medicine of the present invention can significantly improve the total SOD enzyme of modeling mice serum
Vigor.
From Table 2, it can be seen that each dosage group mice serum malonaldehyde (MDA) content of invention formulation and aging model group
Compare and is significantly reduced that ((P < 0.05) shows that Chinese traditional compound medicine of the present invention can significantly reduce mice serum malonaldehyde
(MDA) content has good removing free radical, antioxidation.
It is as follows that the crowd of antioxidant and anti-aging Chinese traditional compound medicine of the present invention takes test effect:
1, principle: malonaldehyde (MDA) is oxygen radical (O2 -.) attack cells plasma membrane, it generates lipid peroxide and further divides
The final metabolite of solution, malonaldehyde (MDA) have very strong bio-toxicity, are the main indicator of human senility, the content of MDA
With oxygen radical (O2 -.) relationship that is positively correlated of concentration.By before detection subject's test-meal, lipid peroxide in urine after test-meal
(MDA) content can substantially judge test-meal product (drug) scavenging activated oxygen, oxidation resistant effect in body.
2, testing program: the age is selected to take subjects, to take drugs and implement for the present invention in 40-66 years old 66 people
The soft capsule that example 1 obtains.Instructions of taking and dosage: postprandial 1 hour warm water takes, 3 tablets each time.
3, detection method: liquid is surveyed using Japan LPO Kit oxidation number speed and is used for quickly detecting, before taking human oral's drug
Urine 1ml is instilled in the ampulla equipped with test agent, and the color of urine reaction solution is observed after 5min, and same method takes human body to take medicine
Urine 1ml after object 2h is instilled in the ampulla equipped with test agent, and the color of urine reaction solution is observed after 5min, compares oral drugs
The difference of forward and backward urine reaction solution color.The color of urine reaction solution is deeper, illustrates that mda content is more, indicates in body
Free-radical contents it is also higher.
4, it judgment criteria: is judged according to effective, effective and invalid three standards.Effective is urine reaction solution before taking
Color is red or peony, and taking rear urine reaction solution is colourless or shallow white；Effective is before the color ratio after taking is taken
Color slightly shoal thin out, the two has the recognizable difference of naked eyes；Invalid is to take the color of forward and backward urine reaction solution without meat
The recognizable difference of eye or the color after taking become deeper than the color before taking.
5, efficacy result: urine reaction solution color of all subjects before taking drugs shows red to dark red
Color shows that malonaldehyde (MDA) content is high in these subject's bodies, and free-radical contents are more.It is anti-oxidant anti-when taking product of the present invention
For aging Chinese traditional compound medicine soft capsule after 2 hours, the urine reaction solution color of most study subjects becomes shallow white or nothing
Color shows the reduction of internal malonaldehyde (MDA) content, and interior free yl is removed in large quantities, this crowd, which takes test, always to be had
Efficiency reaches 85% or more, the results are shown in Table 3.
3 crowd of table takes antioxidant and anti-aging Chinese traditional compound medicine and counts to internal malonaldehyde (MDA) effect is reduced
| Test-meal (people) | Effective (people) | Effectively (people) | (people) in vain | Total effective rate (%) |
| 66 | 45 | 12 | 9 | 86 |
Conclusion: taking test by crowd proves, antioxidant and anti-aging Chinese traditional compound medicine of the present invention can reduce internal malonaldehyde
(MDA) content has good removing interior free yl, anti-oxidant, anti-aging effects.
Claims (2)
1. a kind of antioxidant and anti-aging Chinese traditional compound medicine, it is characterised in that: contain the original of following parts by weight in the Chinese materia medica preparation
Material:
20-38 parts of ginkgo leaf, 20-35 parts of garlic, 18-33 parts of fructus lycii, 16-28 parts of Radix Astragali, 15-24 parts of ginseng, fleece-flower root 12-
18 parts, 10-16 parts of root of kirilow rhodiola, 5-10 parts of pilose antler.
2. a kind of preparation method of antioxidant and anti-aging Chinese traditional compound medicine described in claim 1, it is characterised in that: main packet
Include following processing steps:
(1) fructus lycii, Radix Astragali, ginseng, the fleece-flower root, pilose antler are weighed by weight, are ground into powder, after soaking in water 30 minutes,
80-90 DEG C is extracted twice, wherein once pressing material-water ratio 1:20 extracting in water 2 hours, another time by material-water ratio 1:10 extracting in water 1
Hour, it filters to get filtrate, merging filtrate is concentrated under reduced pressure into thick paste, is dried in vacuo at 55 DEG C -60 DEG C, is ground into powder, mistake
100 meshes obtain powders A, spare；
(2) ginkgo leaf, garlic, root of kirilow rhodiola are weighed by weight, is ground into powder, and after adding 70% ethyl alcohol to impregnate 30 minutes, 55 DEG C super
Sound extracts twice, supersonic frequency 10-15kHz, wherein once pressing solid-liquid ratio 1:15(m/v) plus 60 points of 70% EtOH Sonicate extraction
It is clock, another time to press solid-liquid ratio 1:10(m/v) plus 70% EtOH Sonicate extract 60 minutes, filtration, merging filtrate recycles ethyl alcohol, decompression
It is concentrated into thick paste, obtains alcohol extracting thick paste, it is spare；The dregs of a decoction after taking alcohol extracting, add water to cook it is secondary, wherein one time 10 times of dosing slag amount
Water decocts 60 minutes, 5 times of amount water of another secondary dosing slag, decocts 30 minutes, merges decocting liquid, filters to get filtrate, and is concentrated under reduced pressure
It to thick paste, obtains water and mentions thick paste, merge with above-mentioned alcohol extracting thick paste, be dried in vacuo, be crushed into powder at 55 DEG C -60 DEG C after mixing evenly
End sieves with 100 mesh sieve, and obtains powder B, spare；
(3) powders A prepared by step (1) and powder B prepared by step (2) are uniformly mixed, pharmaceutic adjuvant and plant is added
Object oil, is made soft capsule preparation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109997996A (en) * | 2019-04-22 | 2019-07-12 | 陈永福 | A kind of functional beverage of anti-senility and preparation method thereof |
| CN111773362A (en) * | 2020-07-17 | 2020-10-16 | 北华大学 | Anti-aging composition and preparation method and application thereof |
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2018
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109997996A (en) * | 2019-04-22 | 2019-07-12 | 陈永福 | A kind of functional beverage of anti-senility and preparation method thereof |
| CN111773362A (en) * | 2020-07-17 | 2020-10-16 | 北华大学 | Anti-aging composition and preparation method and application thereof |
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