CN103750324B - A kind of milk basic protein Hericium erinaceus powder composite sheet - Google Patents
A kind of milk basic protein Hericium erinaceus powder composite sheet Download PDFInfo
- Publication number
- CN103750324B CN103750324B CN201410037624.0A CN201410037624A CN103750324B CN 103750324 B CN103750324 B CN 103750324B CN 201410037624 A CN201410037624 A CN 201410037624A CN 103750324 B CN103750324 B CN 103750324B
- Authority
- CN
- China
- Prior art keywords
- hericium erinaceus
- basic protein
- parts
- milk basic
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000013336 milk Nutrition 0.000 title claims abstract description 43
- 239000008267 milk Substances 0.000 title claims abstract description 43
- 210000004080 milk Anatomy 0.000 title claims abstract description 43
- 240000000588 Hericium erinaceus Species 0.000 title claims abstract description 39
- 235000007328 Hericium erinaceus Nutrition 0.000 title claims abstract description 39
- 239000000843 powder Substances 0.000 title claims abstract description 37
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 title claims abstract description 36
- 239000002131 composite material Substances 0.000 title claims abstract description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 16
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 9
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 8
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 8
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 8
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 8
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 8
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 8
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 8
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 8
- 235000019192 riboflavin Nutrition 0.000 claims abstract description 8
- 229960002477 riboflavin Drugs 0.000 claims abstract description 8
- 239000002151 riboflavin Substances 0.000 claims abstract description 8
- 235000019157 thiamine Nutrition 0.000 claims abstract description 8
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960003495 thiamine Drugs 0.000 claims abstract description 8
- 239000011721 thiamine Substances 0.000 claims abstract description 8
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 8
- 229940046009 vitamin E Drugs 0.000 claims abstract description 8
- 239000011709 vitamin E Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 19
- 239000007910 chewable tablet Substances 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 13
- 102000010445 Lactoferrin Human genes 0.000 claims description 11
- 108010063045 Lactoferrin Proteins 0.000 claims description 11
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 11
- 229940078795 lactoferrin Drugs 0.000 claims description 11
- 235000021242 lactoferrin Nutrition 0.000 claims description 11
- 235000012629 Mentha aquatica Nutrition 0.000 claims description 8
- 240000000275 Persicaria hydropiper Species 0.000 claims description 8
- 235000017337 Persicaria hydropiper Nutrition 0.000 claims description 8
- 235000004442 Polygonum persicaria Nutrition 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000005862 Whey Substances 0.000 claims description 7
- 102000007544 Whey Proteins Human genes 0.000 claims description 7
- 108010046377 Whey Proteins Proteins 0.000 claims description 7
- 239000005018 casein Substances 0.000 claims description 7
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 7
- 235000021240 caseins Nutrition 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 7
- 210000003022 colostrum Anatomy 0.000 claims description 7
- 235000021277 colostrum Nutrition 0.000 claims description 7
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 7
- 238000007908 dry granulation Methods 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 7
- 238000005342 ion exchange Methods 0.000 claims description 7
- 230000000813 microbial effect Effects 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000009928 pasteurization Methods 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 2
- 238000011282 treatment Methods 0.000 abstract description 31
- 206010008570 Chloasma Diseases 0.000 abstract description 19
- 208000003351 Melanosis Diseases 0.000 abstract description 19
- 241000590002 Helicobacter pylori Species 0.000 abstract description 15
- 229940037467 helicobacter pylori Drugs 0.000 abstract description 15
- 208000007882 Gastritis Diseases 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 12
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract description 8
- 206010061968 Gastric neoplasm Diseases 0.000 abstract description 7
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 6
- 201000005917 gastric ulcer Diseases 0.000 abstract description 6
- 235000013305 food Nutrition 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 239000000314 lubricant Substances 0.000 abstract description 3
- 210000001156 gastric mucosa Anatomy 0.000 abstract description 2
- 230000002147 killing effect Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000001629 suppression Effects 0.000 abstract description 2
- 230000009931 harmful effect Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 12
- 230000003203 everyday effect Effects 0.000 description 10
- 230000008030 elimination Effects 0.000 description 8
- 238000003379 elimination reaction Methods 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 6
- 230000008029 eradication Effects 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 3
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 208000008469 Peptic Ulcer Diseases 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 208000011906 peptic ulcer disease Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241001502050 Acis Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101000798100 Bos taurus Lactotransferrin Proteins 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 244000060234 Gmelina philippensis Species 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 241000577951 Hydnum Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940072440 bovine lactoferrin Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of milk basic protein Hericium erinaceus powder composite sheet belonging to technical field of health care food.This composite sheet is made up of the material of following parts by weight: milk basic protein 1-10 part, Hericium erinaceus powder 25-70 part, maltodextrin 10-20 part, potassium sorbate 1-2 part, riboflavin 0.01-0.02 part, thiamine 0.01-0.02 part, ascorbic acid 0.01-0.02 part, vitamin E 0.01-0.03 part, lubricant 1-10 part.Composition of the present invention has suppression and killing action preferably for helicobacter pylori, gastric mucosa can be repaired, treatment superficial gastritis, gastric ulcer, Long-Time Service prevention stomach neoplasm, also have obvious curative effect to women's chloasma, composition of the present invention can be used as a kind of food therapeutic health long-term taking, can not produce harmful effect to human body.
Description
Technical field
The invention belongs to field of pharmaceutical technology, being specifically related to one can improve gastritis, reduces the milk basic protein Hericium erinaceus powder composite sheet of women's chloasma.
Background technology
Milk basic protein is rich in bovine lactoferrin, lactoferrin has except as except a kind of food be of high nutritive value, also have antibacterial, antiviral, anticancer, regulate the several functions such as organism immune response, lactoferrin can with Multiple Classes of Antibiotics and antiviral drugs synergy, reduce drug dose, reduction antibiotic or disease-resistant fungi preparation are to human liver, the infringement of renal function, simultaneously, strengthen internal microorganism to the sensitiveness of medicine, along with lactoferrin effect, function, machine-processed constantly illustrates the continuous expansion with Application and Development scope, lactoferrin is in treatment, nutritional supplementation, the aspects such as food have broad application prospects.
Pharmaceutically, hedgehog hydnum head mushroom is a kind of medicine-food two-purpose fungi, and Hericium erinaceus property is put down, the sharp the five internal organs of the sweet energy of taste, aid digestion, nourishing, anticancer, treatment neurasthenia, China has been widely used in curing indigestion, gastric ulcer, the disease of digestive systems such as duodenal ulcer, cancer of the esophagus, cancer of the stomach.Ancient times, elderly and infirm ate Hericium erinaceus, has the effect of nourishing and fit keeping function just by as rare body-building tonic.According to records, the flat taste of Hericium erinaceus property is sweet, has aid digestion, the function of sharp the five internal organs.Modern medicine study proves, the polypeptide contained in Hericium erinaceus, polysaccharide and aliphatic phthalein amine material, have effect of Therapeutic cancer and useful health.
At present along with the sustainable development of China's economy and improving constantly of living standards of the people, the requirement of people to quality of the life is also increased thereupon, and health care consciousness is more and more stronger.Population of China helicobacter pylori carrying rate is up to 50% ~ 70%, and superficial gastritis, gastric ulcer crowd show a rising trend, and radix 1,300,000,000 calculates per capita, and Hp the infected is more than 700,000,000.About half patient does not reach clinical antibiotics treatment category; And the appearance of a large amount of antibody-resistant bacterium is also the significant challenge of Current treatments in the person that needs antibiotic therapy.
Along with environment constantly worsens and aging trend, women's chloasma number constantly increases, and people generally adopt chemical toilet to make up and go to cover chloasma, but, there is side effect with chemical toilet to human body for a long time, cause the deeper injury of human body skin.
Summary of the invention
The present invention is directed to and carry helicobacter pylori infection number at present and constantly rise, superficial gastritis, patients w ith peptic ulcer disease increases and the ever-increasing problem of women's chloasma number, proposes a kind of milk basic protein Hericium erinaceus powder composite sheet.
A kind of milk basic protein Hericium erinaceus powder composite sheet, be made up of the material of following parts by weight: milk basic protein 1-10 part, Hericium erinaceus powder 25-70 part, maltodextrin 10-20 part, potassium sorbate 10-20 part, riboflavin 0.01-0.02 part, thiamine 0.01-0.02 part, ascorbic acid 0.01-0.02 part, vitamin E 0.01-0.03 part, lubricant 1-10 part.
Active component in described milk basic protein is lactoferrin.
Described milk basic protein extracts and obtains from milk, and described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 3100-4000rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopts microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, whey is collected, Vacuum Concentration, freeze drying is made.
Described Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80-300 order.
Described lubricant is talcum powder, odium stearate, dolomol, adipic acid, esters of silicon acis, one or more in phosphate.
The preparation method of above-mentioned milk basic protein Hericium erinaceus powder composite sheet, adopts compressing dry granulation or wet granule compression tablet to obtain.
Beneficial effect of the present invention: composition of the present invention has suppression and killing action preferably for helicobacter pylori, can repair gastric mucosa, treatment superficial gastritis, gastric ulcer, Long-Time Service prevention stomach neoplasm, also has obvious curative effect to women's chloasma.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of milk basic protein Hericium erinaceus powder composite sheet, is made up of the material of following parts by weight: milk basic protein 1 part, 70 parts, Hericium erinaceus powder, maltodextrin 18 parts, potassium sorbate 10 parts, 0.01 part, riboflavin, thiamine 0.01 part, 0.01 part, ascorbic acid, vitamin E 0.01 part, talcum powder 1 part.
Milk basic protein extracts and obtains from milk, and described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 3100rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopts microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, whey is collected, Vacuum Concentration, freeze drying is made.Active component in the milk basic protein of preparation is lactoferrin, and content reaches more than 70%.
Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80 orders.
Adopting compressing dry granulation above-mentioned composition component to be made chewable tablets, every sheet 2g, is finished product.
Embodiment 2
A kind of milk basic protein Hericium erinaceus powder composite sheet, be made up of the material of following parts by weight: milk basic protein 2 parts, 60 parts, Hericium erinaceus powder, maltodextrin 20 parts, potassium sorbate 15 parts, 0.015 part, riboflavin, thiamine 0.015 part, 0.015 part, ascorbic acid, vitamin E 0.015 part, talcum powder 1 part.
Milk basic protein extracts and obtains from milk, and described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 3800rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopts microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, whey is collected, Vacuum Concentration, freeze drying is made.Active component in the milk basic protein of preparation is lactoferrin, and content reaches more than 70%.
Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80 orders.
Adopting compressing dry granulation above-mentioned composition component to be made chewable tablets, every sheet 2g, is finished product.
Embodiment 3
A kind of milk basic protein Hericium erinaceus powder composite sheet, is made up of the material of following parts by weight: milk basic protein 3 parts, 50 parts, Hericium erinaceus powder, maltodextrin 20 parts, potassium sorbate 20 parts, 0.02 part, riboflavin, thiamine 0.02 part, 0.02 part, ascorbic acid, vitamin E 0.02 part, talcum powder 2 parts.
Milk basic protein extracts and obtains from milk, and described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 4000rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopts microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, whey is collected, Vacuum Concentration, freeze drying is made.Active component in the milk basic protein of preparation is lactoferrin, and content reaches more than 70%.
Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80 orders.
Adopting compressing dry granulation above-mentioned composition component to be made chewable tablets, every sheet 5g, is finished product.
Embodiment 4
A kind of milk basic protein Hericium erinaceus powder composite sheet, is made up of the material of following parts by weight: milk basic protein 4 parts, 50 parts, Hericium erinaceus powder, maltodextrin 20 parts, potassium sorbate 15 parts, 0.01 part, riboflavin, thiamine 0.02 part, 0.01 part, ascorbic acid, vitamin E 0.02 part, talcum powder 8 parts.
Milk basic protein extracts and obtains from milk, and described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 3900rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopts microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, whey is collected, Vacuum Concentration, freeze drying is made.Active component in the milk basic protein of preparation is lactoferrin, and content reaches more than 70%.
Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80 orders.
Adopting compressing dry granulation above-mentioned composition component to be made chewable tablets, every sheet 2g, is finished product.
Embodiment 5
Superficial gastritis Experiment on therapy method: select 80 examples to infect the superficial gastritis patient of helicobacter pylori, be divided into treatment group (40 example) and control group (40 example), treatment group adopts the chewable tablets treatment of embodiment 1, takes 2 every day, each serving with 20g, control group adopts ranitidine hydrochloride treatment, take 2 every day, each serving with 150mg, treatment cycle is one month, drug withdrawal checked gastroscope after 1 month, observed helicobacter pylori eradication situation.
Superficial gastritis Experiment on therapy result: treatment group and the eradication rate of control group to helicobacter pylori are respectively 85.3% and 74.6%, and treatment group curative effect is better than control group, prove that this chewable tablets can reach the effect of effective eradicate helicobacter pylori.
Gastric ulcer Experiment on therapy method: select 80 examples to infect the patients w ith peptic ulcer disease of helicobacter pylori, be divided into treatment group (40 example) and control group (40 example), treatment group adopts the chewable tablets treatment of embodiment 1, takes 2 every day, each serving with 20g, control group adopts ranitidine hydrochloride treatment, take 2 every day, each serving with 150mg, treatment cycle is one month, drug withdrawal checked gastroscope after 1 month, observed helicobacter pylori eradication situation.
Gastric ulcer Experiment on therapy result: treatment group and the eradication rate of control group to helicobacter pylori are respectively 61.1% and 51.1%, and treatment group curative effect is better than control group, prove that this chewable tablets can reach the effect of effective eradicate helicobacter pylori.
Chloasma improves experimental technique: select women 80 example suffering from yellowish-brown pinta, age is between 45-55 year, take the chewable tablets of embodiment 1, take 2 every day, each serving with 20g, taking chloasma elimination factor after 3 months is 5%, and after taking half a year, chloasma elimination factor is 40%, taking chloasma elimination factor after a year is 70%, and after taking a year and a half, chloasma elimination factor is 70%.Above-mentioned experiment proves that said composition has certain therapeutic action to chloasma.
Stomach neoplasm Inhibition test method: select 80 experimental mouse suffering from stomach neoplasm, the size of stomach neoplasm is identical, be divided into treatment group (40 example) and control group (40 example), treatment group adopts the chewable tablets treatment of embodiment 1, throws something and feeds every day 2 times, throw something and feed 10g at every turn, control group throw something and feed conventional feed raise, throw something and feed every day 2 times, throw something and feed 10g at every turn, after 1 month, the increase situation of statistics tumour.
Stomach neoplasm Inhibition test result: the Magnification of control group mice tumour is 100%, treatment group has 20% mouse tumor to increase, and 50% mouse tumor size is constant, and 30% mouse tumor diminishes, and proves that said composition has certain inhibitory action to stomach neoplasm.
Embodiment 6
A kind of milk basic protein Hericium erinaceus powder composite sheet, be made up of the material of following parts by weight: milk basic protein 5 parts, 40 parts, Hericium erinaceus powder, smartweed extract 20 parts, maltodextrin 15 parts, potassium sorbate 15 parts, 0.01 part, riboflavin, thiamine 0.01 part, 0.01 part, ascorbic acid, vitamin E 0.01 part, talcum powder 4 parts.
Milk basic protein extracts and obtains from milk, and described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 3900rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopts microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, whey is collected, Vacuum Concentration, freeze drying is made.Active component in the milk basic protein of preparation is lactoferrin, and content reaches more than 70%.
The extracting method of described smartweed extract is: dried by smartweed, pulverizes, and loads to decoct in bag to soak 3-10h, moves in Decocting pot, decocts 5-9h, finally by decoction liquor powder by spraying, obtain smartweed extract under temperature 90-100 degree condition.
Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80 orders.
Adopting compressing dry granulation above-mentioned composition component to be made chewable tablets, every sheet 5g, is finished product.
The chewable tablets made is divided into two groups, and one group is carried out superficial gastritis Experiment on therapy, and one group is carried out chloasma and improves experiment.
Superficial gastritis Experiment on therapy method: select 80 examples to infect the superficial gastritis patient of helicobacter pylori, be divided into treatment group (40 example) and control group (40 example), treatment group adopts the chewable tablets treatment of embodiment 1, takes 2 every day, each serving with 20g, control group adopts ranitidine hydrochloride treatment, take 2 every day, each serving with 150mg, treatment cycle is one month, drug withdrawal checked gastroscope after 1 month, observed helicobacter pylori eradication situation.
Superficial gastritis Experiment on therapy result: treatment group and the eradication rate of control group to helicobacter pylori are respectively 95.3% and 74.6%, treatment group curative effect is better than control group, and be better than the experimental result of embodiment 1, prove that this chewable tablets can reach the effect of effective eradicate helicobacter pylori.
Chloasma improves experimental technique: select women 80 example suffering from yellowish-brown pinta, age is between 45-55 year, take the chewable tablets of embodiment 1, take 2 every day, each serving with 20g, taking chloasma elimination factor after 3 months is 10%, and after taking half a year, chloasma elimination factor is 50%, taking chloasma elimination factor after a year is 80%, and after taking a year and a half, chloasma elimination factor is 80%.Above-mentioned experiment proves that said composition has certain therapeutic action to chloasma.
Claims (1)
1. a milk basic protein Hericium erinaceus powder composite sheet, it is characterized in that, be made up of the material of following parts by weight: milk basic protein 5 parts, 40 parts, Hericium erinaceus powder, smartweed extract 20 parts, maltodextrin 15 parts, potassium sorbate 15 parts, 0.01 part, riboflavin, thiamine 0.01 part, 0.01 part, ascorbic acid, vitamin E 0.01 part, talcum powder 4 parts;
Described milk basic protein extracts and obtains from milk, described extracting method is: collect colostrum, under 6-8 DEG C of condition with the rotating speed of 3900rpm centrifugal 2 minutes, removing impurity, under 64 DEG C of conditions, pasteurization 30min, adopt microbial method or ion-exchange removing casein, break up clots, then under 4 DEG C of conditions, with 7500rpm centrifugation 15min, collect whey, Vacuum Concentration, freeze drying is made, active component in the milk basic protein of preparation is lactoferrin, and content reaches more than 70%;
The extracting method of described smartweed extract is: dried by smartweed, pulverizes, and loads to decoct in bag to soak 3-10h, moves in Decocting pot, decocts 5-9h, finally by decoction liquor powder by spraying, obtain smartweed extract under temperature 90-100 DEG C of condition;
Described Hericium erinaceus powder is that Hericium erinaceus dry product grinds and makes, and the size of powder particles ground is 80 orders;
Adopt compressing dry granulation that composition is made chewable tablets, every sheet 5g, gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410037624.0A CN103750324B (en) | 2014-01-27 | 2014-01-27 | A kind of milk basic protein Hericium erinaceus powder composite sheet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410037624.0A CN103750324B (en) | 2014-01-27 | 2014-01-27 | A kind of milk basic protein Hericium erinaceus powder composite sheet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103750324A CN103750324A (en) | 2014-04-30 |
| CN103750324B true CN103750324B (en) | 2016-04-13 |
Family
ID=50517777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410037624.0A Active CN103750324B (en) | 2014-01-27 | 2014-01-27 | A kind of milk basic protein Hericium erinaceus powder composite sheet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103750324B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435213A (en) * | 2014-08-11 | 2016-03-30 | 上海杰隆生物工程股份有限公司 | Method for using lactoferrin for treatment or prevention of helicobacter pylori infection |
| CN104984329A (en) * | 2015-06-17 | 2015-10-21 | 上海善力健生物科技有限公司 | Micro-ecology and Chinese herbal medicine compound preparation for treating gastrointestinal diseases and preparation method thereof |
| CN105125688B (en) * | 2015-09-06 | 2016-08-17 | 罗泽华 | A kind of relieving haperacidity analgesic composition containing milk basic protein and preparation method thereof |
| CN105815658A (en) * | 2016-03-28 | 2016-08-03 | 合肥赛为智慧医疗有限公司 | Milk basic protein ferroporphyrin composite piece and preparing method thereof |
| CN106107952A (en) * | 2016-07-07 | 2016-11-16 | 江苏恩凯生物科技有限公司 | A kind of milk basic protein fraction powder Hericium erinaceus (Bull. Ex Fr.) Pers. powder composite sheet |
| CN107912589A (en) * | 2017-12-21 | 2018-04-17 | 广州莱可福生物科技有限公司 | Containing probiotics and enteron aisle and the pressed candy of immunity and preparation method thereof can be improved |
| CN108041591A (en) * | 2017-12-30 | 2018-05-18 | 广州润虹医药科技股份有限公司 | A kind of gastric mucosa composition and preparation method thereof |
| CN110507816A (en) * | 2019-09-20 | 2019-11-29 | 江西善行生物科技有限公司 | It is a kind of for removing the compound formulation of HPV |
| CN117503800B (en) * | 2024-01-04 | 2024-04-05 | 北京益华生物科技有限公司 | Gastric mucosa epithelial cell extract and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1762236A (en) * | 2005-11-02 | 2006-04-26 | 江中药业股份有限公司 | Health-caring product capable of increasing human immunity and its preparation method |
| CN1840180A (en) * | 2006-01-19 | 2006-10-04 | 方雅悯 | Application of bovine lactoferricin in preparation of medicine for treating gastric disease and reducing secretion of gastric acid |
| CN103202461A (en) * | 2013-03-27 | 2013-07-17 | 洛阳春魁农业开发有限公司 | Preparation method of hericium erinaceus powder |
-
2014
- 2014-01-27 CN CN201410037624.0A patent/CN103750324B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1762236A (en) * | 2005-11-02 | 2006-04-26 | 江中药业股份有限公司 | Health-caring product capable of increasing human immunity and its preparation method |
| CN1840180A (en) * | 2006-01-19 | 2006-10-04 | 方雅悯 | Application of bovine lactoferricin in preparation of medicine for treating gastric disease and reducing secretion of gastric acid |
| CN103202461A (en) * | 2013-03-27 | 2013-07-17 | 洛阳春魁农业开发有限公司 | Preparation method of hericium erinaceus powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103750324A (en) | 2014-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103750324B (en) | A kind of milk basic protein Hericium erinaceus powder composite sheet | |
| CN106413724B (en) | Lactobacillus rhamnosus RHT-3201 conjugated with polysaccharide polymer binder and uses thereof | |
| KR101826737B1 (en) | A composition containing herbs extract, and manufacturing method of the same | |
| KR20140128004A (en) | Composition for preventing and improving of diarrhea of calf and manufacturing method thereof | |
| CN107927653A (en) | A kind of sea cucumber peptide product for improving immunity and preparation method thereof | |
| CN105533753A (en) | Medicinal and edible microcirculation obstacle preventing and curing compound nutrient | |
| CN105029392A (en) | Medical formula food for nasopharynx cancer | |
| CN104489279A (en) | Chinese traditional herb feed additive for treating cow mastitis | |
| JP2011184349A (en) | Frequent urination-ameliorating composition, healthy food and blood flow-ameliorating composition | |
| CN105943679A (en) | Traditional Chinese medicine probiotic compound preparation for poultry and preparation method thereof | |
| CN109498709A (en) | A kind of Chinese medicine composition and preparation method thereof for treating mastitis for milk cows | |
| CN109601982A (en) | A kind of health food and the preparation method and application thereof with eliminate chloasma function | |
| CN101612335A (en) | Be used to Chinese medicine composition of preventing and treating mammitis of cow and preparation method thereof | |
| CN104274619A (en) | Externally-applied pharmaceutical composition for preventing and treating cow mastitis and preparation method of externally-applied pharmaceutical composition | |
| RU2448529C1 (en) | Method for correction of organism digestive system homeostasis disruption | |
| CN107811132A (en) | A kind of pet pup growth promotion dog food additive and preparation method thereof | |
| CN109646546B (en) | A Chinese medicinal composition for preventing and treating diarrhea of livestock, and its preparation method | |
| CN103750096A (en) | Propolis honey cream rich in plant essence and preparation method thereof | |
| CN103948738B (en) | A kind of bird's nest composition with relieving sore-throat antiinflammation and its preparation method and application | |
| CN110050972B (en) | Aloe and hawthorn ball and preparation method thereof | |
| CN105663256A (en) | Ultramicro traditional Chinese medicine for preventing and treating lactation reduction and redness and swelling of breasts of dairy cows | |
| KR101824016B1 (en) | Pharmaceutical composition for preventing or treating arthritis comprising extract of Taraxacum platycarpum H. Dahlsi, Saururus chinensis Baill, Lonicera japonica Thunb, Commiphora myrrha Engl., Clematis manshurica Rupr, Alisma orientalis (Sam) Juzep, Akebia quinata Decne, Plantago asiatica L, Ulmus pumila L., Phyllostachys nigra var. henonis (Bean.) Stapf, Cassia tora L, Angelica gigas Nakai, Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fisch. as an active ingradient | |
| CN113750182A (en) | Medicinal and edible composition for preventing and treating gout as well as preparation method and application thereof | |
| CN111972656A (en) | Mushroom sauce and preparation method thereof | |
| CN108783443A (en) | A kind of tablet and preparation method thereof for internal organs conditioning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170427 Address after: 230000 Anhui, Hefei innovation Avenue, race for the building 666 Patentee after: HEFEI SUNWIN SMART HEALTHCARE CO., LTD. Address before: Room 1, building 168, Fenghuang West Road, Jiangsu, Taizhou, 225300, China Patentee before: TAIZHOU BIERFU BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. |
|
| TR01 | Transfer of patent right |