CN103948738B - A kind of bird's nest composition with relieving sore-throat antiinflammation and its preparation method and application - Google Patents
A kind of bird's nest composition with relieving sore-throat antiinflammation and its preparation method and application Download PDFInfo
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- CN103948738B CN103948738B CN201410096130.XA CN201410096130A CN103948738B CN 103948738 B CN103948738 B CN 103948738B CN 201410096130 A CN201410096130 A CN 201410096130A CN 103948738 B CN103948738 B CN 103948738B
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Abstract
The invention discloses a kind of composition with relieving sore-throat antiinflammation and its preparation method and application, said composition is made up of the raw material of following parts by weight：1 to 10 part of bird's nest, 1 to 10 part of honeysuckle, 1 to 10 part of balloonflower root, 1 to 10 part of Radix Angelicae Sinensis, 1 to 10 part of matrimony vine.The composition that the present invention is provided, according to traditional Chinese medical theory, theoretical using diagnosis and treatment carries out Chinese medicine proportioning prescription, test result indicates that, the composition proportioning that the present invention is provided is scientific and reasonable, with good relieving sore-throat anti-inflammatory, improve effect of immunity, sphagitis can effectively be prevented and treated, and screen preparation technology by many experiments, the optimal enzymolysis process of bird's nest is filtered out especially by many experiments, prepare the strong bird's nest zymolyte of activity, then honeysuckle is prepared by selection process, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract, prepare with fine relieving sore-throat anti-inflammatory and improve the composition of immunity.It can be developed into the medicine or health products for new relieving sore-throat anti-inflammatory.
Description
Technical field
The present invention relates to a kind of composition, and in particular to a kind of composition with relieving sore-throat antiinflammation and preparation method thereof
With its application.
Background technology
Sphagitis is, by a kind of bacterial disease, can be divided into two kinds of acute laryngopharyngitis and pharyngo-laryngitis chronica, acute pharynx
It is scorching：Winter-spring season is the most common.Adult based on pharyngeal symptom, disease just it is pharyngeal have it is dry itch, it is scorching hot, gradually have pain, add when swallowing
Weight, excessive saliva, lateral pharyngeal band involvement then has obvious otalgia.
Chronic pharyngitis：Thoroughly recurrent exerbation is treated not mainly due to acpuei pharyngitis, is switched to chronic or each because of suffering from
Planting rhinopathy, nose key obstruction, long-term mouth breathing, and physics, chemical factor, neck radiotherapy etc. often stimulates pharyngeal institute
Cause.Pharyngeal discomfort is felt, does, itch, swollen, secretion is more and cusalgia, easily nausea, has foreign body sensation, not out can not swallow, with
Upper symptom is being spoken slightly many, after overfeeding irritable food, fatigue or is aggravated during Changes in weather.
At present, the active drug for the treatment of sphagitis is few, in particular in the safe and effective pharmaceutical market of chronic pharyngitis
Less, traditional Chinese medicine has unique advantage in terms of chronic pharyngitis is prevented and treated.
Bird's nest is by Apodidae（Apodidae）Aerodramus（Collocalia）And belong to a variety of esculent swifts together to bring up young bird
Bird, is mixed and condensed on overhanging cliff with the saliva or saliva and a small amount of fine hair secreted out of, and the nest built up.Bird's nest main product
It is Chinese tradition nourishing cosmetic good merchantable brand for Indonesia, Malaysia, Vietnam etc., according to《Bencao Shiyi》Record：" bird's nest is sweet
It is light flat, support lung yin greatly, preventing phlegm from forming and stopping coughing, mend and can be clear, to nurse one's health the panacea of consumptive disease, all diseases due to the deficiency syndrome of the lung, and can not eliminate
Lower passerby, it can be all controlled with this." traditional Chinese medical science thinks, bird's nest nourishing yin to moisten dryness, invigorating middle warmer and replenishing QI, governance wasting, expectoration are breathed heavily, spat blood, protracted dysentery,
Be suitable for having a delicate constitution, malnutritive, protracted dysentery chronic malaria, many coughs of phlegm, senile chronic bronchitis, bronchiectasis, pulmonary emphysema,
Pulmonary tuberculosis, spitting of blood, haematemesis and stomachache patients.
Therefore, necessary on the basis of prior art, design research and development are a kind of to match scientific and reasonable, determined curative effect,
Clinical practice safety, adverse reaction is low, the composition with relieving sore-throat anti-inflammatory and raising immunity.
The content of the invention
Goal of the invention：Present invention aims to solve the deficiencies of the prior art, and provides a kind of one kind proportioning it is scientific and reasonable, curative effect is true
Cut, Clinical practice safety, adverse reaction is low, the composition with good relieving sore-throat anti-inflammatory and raising immunity；The present invention is another
Individual purpose is to provide the preparation method of said composition and its is preparing the application in preventing and treating sphagitis medicine.
Technical scheme：In order to realize the above object the technical scheme that the present invention takes is：
A kind of composition with relieving sore-throat antiinflammation, it is made up of the raw material of following parts by weight：1 to 10 part of bird's nest,
1 to 10 part of honeysuckle, 1 to 10 part of balloonflower root, 1 to 10 part of Radix Angelicae Sinensis, 1 to 10 part of matrimony vine.
Preferably, the above-described composition with relieving sore-throat antiinflammation, it by following parts by weight original
Material is made：1 to 5 part of bird's nest, 1 to 5 part of honeysuckle, 1 to 5 part of balloonflower root, 1 to 5 part of Radix Angelicae Sinensis, 1 to 5 part of matrimony vine.
As more excellent scheme, the above-described composition with relieving sore-throat antiinflammation, it is by following parts by weight
Raw material is made：5 parts of bird's nest, 2.5 parts of honeysuckle, 2.5 parts of balloonflower root, 2.5 parts of Radix Angelicae Sinensis, 2.5 parts of matrimony vine.
Composition of the present invention with relieving sore-throat antiinflammation, by each raw extract and pharmaceutically acceptable load
Body is prepared into the medicine or health products of granule, capsule, tablet or pellet form.
Described tablet can be ordinary tablet, chewable tablets, lozenge, oral disintegrating tablet, effervescent tablet, multilayer tablet etc..
When tablet is made in the extract of each raw material for the composition that the present invention is provided, each raw material and mannitol, starch
Or sodium carboxymethyl starch or PVPP, steviol glycoside, add magnesium stearate lubricant when needing, it is well mixed, whole grain, so
Tablet is made in tabletting afterwards.
The extract and carrier lactose or jade of each raw material when the extract for the composition that the present invention is provided is made capsule
Rice starch is well mixed, and whole grain is then encapsulated that capsule is made.
When oral liquid is made in the extract of each raw material for the composition that the present invention is provided, the extract of each raw material is added into distillation
Water dissolves, filtering, adds syrup, adjusts pH value, oral liquid is made.
When granule is made in the extract of each raw material for the composition that the present invention is provided, extract and dilution each raw material
Agent lactose or cornstarch are well mixed, and whole grain is dried, granule is made.
The preparation method of composition of the present invention with relieving sore-throat antiinflammation, comprises the following steps：
（1）Take bird's nest, plus the water of 10~50 times of amounts of bird's nest weight to soak by weight 5~12 hours, then add egg
White enzyme enzymolysis, digests 0.5~4 hour under conditions of 30~45 DEG C and pH value 4~9, inactivates, and filtering obtains bird's nest enzymolysis liquid, does
Bird's nest zymolyte is obtained after dry, it is standby；
（2）Extracting honeysuckle, balloonflower root, Radix Angelicae Sinensis and matrimony vine by weight, add 6 to 15 times of amounts of medicinal material, and concentration is 30%~
70% ethanol, extracts 1 to 3 time, 1 to 3 hour every time, merges extract solution, concentrate, dry, obtain honeysuckle, balloonflower root, Radix Angelicae Sinensis and Chinese holly
Qi extract, it is standby；
（3）Step is taken respectively（1）Bird's nest zymolyte, step（2）Honeysuckle, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract, mixing are equal
It is even, add on food or pharmaceutically acceptable carrier is prepared into health products or medicine.
Preferably, the preparation method of the above-described composition with relieving sore-throat antiinflammation, step（1）It is described
Protease be trypsase, pepsin, neutral proteinase, flavor protease, papain or compound protease；It is described
Drying means be freeze-drying, fluidized bed drying or spray drying.
Preferably, the preparation method of the above-described composition with relieving sore-throat antiinflammation, step (1) enzymolysis
Temperature be 37 DEG C, pH value is 8, enzymolysis time be 3 hours.
Application of the composition of the present invention with relieving sore-throat antiinflammation in anti-sphagitis medicine is prepared.
Beneficial effect：The composition that the present invention is provided has advantages below：
The composition that the present invention is provided, according to traditional Chinese medical theory, compatibility is determined using diagnosis and treatment, and by many experiments
Prescription, composition proportioning it is scientific and reasonable, after each flavour of a drug compatibility, reach jointly invigorating middle warmer and replenishing QI, clearing moisturize, clearing heat and detoxicating work(
The sweet light flat profit of bird's nest in effect, side, supports greatly lung yin, resolving sputum, which stops, coughs, and solution food cigarette poison, matrimony vine, sweet, mild-natured blood-enriching tranquillizing promotes the production of body fluid only
Yearningly, moisten the lung and relieve the cough, tonifying kidney and benefiting sperm effect；Radix Angelicae Sinensis is warm-natured, acrid-sweet flavor, the thoughts of returning home, liver, the spleen channel, with benefiting blood and regulating blood circulation, suppresses blood platelet
The effects such as cohesion, antithrombotic, regulation blood fat is ministerial drug；Balloonflower root cough-relieving apophlegmatic, effect of facilitaing lung relieving sore-throat is adjutant；All medicines share,
Clearing heat and detoxicating, clearing throat is played altogether, is strengthened the body resistance to consolidate the constitution, and the work(of the clear and rich deficiency syndrome of the lung makes the clear respectful descending duty of lung row.Each medicine is shared, and is played altogether
Clearing heat and detoxicating, clearing throat, the work(of the clear and rich deficiency syndrome of the lung makes the clear respectful descending duty of lung row, and can improve body resistivity, prevents disease
Disease recurrence.
In addition, the preparation method for the composition that the present invention is provided, preparation technology is screened by many experiments, especially by
Many experiments filter out the optimal enzymolysis process of bird's nest（Filter out the protease for most preferably digesting and using, the optimum temperature 37 of enzymolysis
DEG C, pH value is 8 and enzymolysis time is the optimised process such as 3 hours）, the strong bird's nest zymolyte of activity is prepared, then by excellent
Select technique to prepare honeysuckle, balloonflower root, Radix Angelicae Sinensis and matrimony vine, prepare with fine relieving sore-throat anti-inflammatory and improve the group of immunity
Compound.
The extract of the present composition can facilitate and pharmaceutical carriers are prepared into a variety of formulations, clinically convenient to take,
And test result indicates that the composition that the present invention is provided, using safety, long-term use has no toxic side effect.The present invention is provided simultaneously
The preparation method of Chinese traditional compound medicine, technological design is reasonable, effective component extracting content is high, workable, is adapted to industrialization
Big production.
Embodiment
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
Limitation the scope of the present invention is not used in, after the present invention has been read, various of equal value shapes of the those skilled in the art to the present invention
The modification of formula falls within the application appended claims limited range.
Embodiment 1
1st, a kind of composition with relieving sore-throat antiinflammation, it is made up of the raw material of following parts by weight：5 parts of bird's nest, gold
2.5 parts of honeysuckle flower, 2.5 parts of balloonflower root, 2.5 parts of Radix Angelicae Sinensis, 2.5 parts of matrimony vine.
2nd, the preparation method of the composition of the present invention with relieving sore-throat antiinflammation, comprises the following steps：
（1）Take 5 parts of bird's nest, plus the water of 20 times of amounts of bird's nest weight to soak 8 hours, trypsin digestion is then added, 37
DEG C and pH=8 under the conditions of digest 3 hours, inactivate, filtering obtains bird's nest enzymolysis liquid, add 10% mannitol after enzymolysis liquid concentration, spray
Bird's nest zymolyte is dried to obtain, it is standby；
（2）2.5 parts of extracting honeysuckle, 2.5 parts of balloonflower root, 2.5 parts of Radix Angelicae Sinensis, 2.5 parts of matrimony vine, adding 12 times of amount concentration of medicinal material is
40% ethanol, extracts 3 times, 3 hours every time, merges extract solution, concentrate, dry, obtain honeysuckle, ginseng and Bulbus Lilii extract, standby
With；
（3）Step is taken respectively（1）Bird's nest zymolyte, step（2）Honeysuckle, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract, mixing are equal
It is even, 1% steviol glycoside is added, 40% sodium carboxymethyl starch is fully mixed, wetting agent, wet method pelleting, particle are made with 85% ethanol
Dry, whole grain, add 1% magnesium stearate and always mix, tabletting obtains oral disintegrating tablet.
Embodiment 2
1st, a kind of composition with relieving sore-throat antiinflammation, it is made up of the raw material of following parts by weight：10 parts of bird's nest, gold
10 parts of honeysuckle flower, 10 parts of balloonflower root, 10 parts of Radix Angelicae Sinensis, 10 parts of matrimony vine.
2nd, the preparation method of the composition of the present invention with relieving sore-throat antiinflammation, comprises the following steps：
（1）Take 10 parts of bird's nest, plus the water of 30 times of amounts of bird's nest weight to soak 12 hours, then add trypsin digestion,
40 DEG C digest 4 hours with the conditions of pH=9, inactivate, filtering, obtain bird's nest enzymolysis liquid, add 10% mannitol after enzymolysis liquid concentration, spray
Mist is dried to obtain bird's nest zymolyte, standby；
（2）2.5 parts of extracting honeysuckle, 2.5 parts of balloonflower root, 2.5 parts of Radix Angelicae Sinensis, 2.5 parts of matrimony vine, adding 15 times of amount concentration of medicinal material is
50% ethanol, extracts 2 times, 3 hours every time, merges extract solution, concentrate, dry, obtain honeysuckle, balloonflower root, Radix Angelicae Sinensis and matrimony vine and extract
Thing, it is standby；
（3）Step is taken respectively（1）Bird's nest zymolyte, step（2）Honeysuckle, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract, mixing are equal
It is even, 1% steviol glycoside is added, lactose, milk powder is mixed, wetting agent is made with 70% ethanol, wet method makes pellet, particle drying, whole grain,
Add 1% magnesium stearate always to mix, tabletting obtains bird's nest chewable tablets.
Embodiment 3
1st, a kind of composition with relieving sore-throat antiinflammation, it is made up of the raw material of following parts by weight：5 parts of bird's nest, gold
5 parts of honeysuckle flower, 5 parts of balloonflower root, 5 parts of Radix Angelicae Sinensis, 5 parts of matrimony vine.
2nd, the preparation method of the composition of the present invention with relieving sore-throat antiinflammation, comprises the following steps：
（1）Take 5 parts of bird's nest, plus the water of 30 times of amounts of bird's nest weight to soak 10 hours, trypsin digestion is then added, 35
DEG C and pH=7 under the conditions of digest 2 hours, inactivate, filtering obtains bird's nest enzymolysis liquid, add 5% mannitol after enzymolysis liquid concentration, spray
Bird's nest zymolyte is dried to obtain, it is standby；
（2）5 parts of extracting honeysuckle, 5 parts of balloonflower root, 5 parts of Radix Angelicae Sinensis, 5 parts of matrimony vine adds the ethanol that 15 times of amount concentration of medicinal material are 60%,
Extract 3 times, 2 hours every time, merge extract solution, concentrate, dry, obtain honeysuckle, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract, it is standby；
（3）Step is taken respectively（1）Bird's nest zymolyte, step（2）Honeysuckle, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract, mixing are equal
It is even, 1% steviol glycoside is added, 20% sodium carboxymethyl starch, lactose, starch is mixed in right amount, and wetting agent, wet method are made with 85% ethanol
Pelleting, particle drying, whole grain adds 1% magnesium stearate and always mixed, tabletting obtains bird's nest lozenge.
The pharmacological experiment study of embodiment 4
1. experimental animal
Cleaning grade SD rats, male and female half and half, 150~200g, by Nanjing Medical University, animal center is provided, and the quality certification is compiled
Number：0011658；Experimental animal production licence number：SCXK（Soviet Union）2008-0004.
2. Experimental agents
2.1 positive drug：Acetylsalicylic acid tablet（100mg/kg）, Baijingyu Pharmaceutical Co., Ltd., Nanjing.
2.2 test medicine：
The composition extract that the embodiment of the present invention 1 is prepared, low dose group（5g crude drugs/kg）, middle dose group（10g
Crude drug/kg）, high dose group（20g crude drugs/kg）.
3. experimental method
Carrageenan causes Rat Right plantar swelling experiment：Every group of 10 rats, male and female half and half, fasting 18~22 is small before experiment
When, but can't help water.Rat oral gavage is administered, administered volume is 1ml/100g.Administration 30 minutes after, to Rat Right after aponeurosis (aponeuroses) bet
Penetrate 1% carrageenan（Sterile saline is prepared）0.1ml, determines before cause inflammation and causes 1,2,3,4,5 hours Rat Right plantar bodies after inflammation
Product, is calculated as follows swelling.
4th, experimental result
Specific experiment the results are shown in Table 1 and table 2, can be seen that in table, and composition middle dose group is respectively provided with suppression with high dose group
Carrageenan processed causes the effect of rat paw edema, and otherness is notable.
Pedal swelling situation before and after the rat modeling of table 1（ml）
Note：Compared * P with model group<0.05, * * P<0.01.
The rat paw edema rate of table 2（%）
Note：Compared * P with model group<0.05, * * P<0.01.
The clinical observation experiment of embodiment 5
Selection clinical diagnosis is pharyngo-laryngitis chronica patient 90, ill in 2 to 15 years, and patient shows dry throughout the year, pharyngalgia,
It is cold to be susceptible to suffer from tonsillitis, the symptom such as cough, takes the Traditional Chinese medicine compound composition of the embodiment of the present invention 22 months, dry, pharyngalgia,
The symptoms such as cough disappear, wherein 40 recoveries from illness, cure rate 44.4%, effective percentage is 90%, and follow-up is no longer recurred for 1 year after recovery from illness.
The present invention is according to traditional Chinese medical theory, and theoretical using diagnosis and treatment carries out proportioning prescription, passes through above experimental result
Show, the composition that the present invention is provided has effects that good relieving sore-throat anti-inflammatory, can be effectively used for preventing and treating sphagitis, improve immune
Power, and adverse reaction is low, it is safe, it is expected to develop into the new medicine for preventing and treating sphagitis.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of composition with relieving sore-throat antiinflammation, it is characterised in that it is made up of the raw material of following parts by weight：Bird's nest
1 to 10 part, 1 to 10 part of honeysuckle, 1 to 10 part of balloonflower root, 1 to 10 part of Radix Angelicae Sinensis, 1 to 10 part of matrimony vine.
2. the composition according to claim 1 with relieving sore-throat antiinflammation, it is characterised in that it is by following parts by weight
Raw material be made：1 to 5 part of bird's nest, 1 to 5 part of honeysuckle, 1 to 5 part of balloonflower root, 1 to 5 part of Radix Angelicae Sinensis, 1 to 5 part of matrimony vine.
3. the composition according to claim 2 with relieving sore-throat antiinflammation, it is characterised in that it is by following parts by weight
Raw material be made：5 parts of bird's nest, 2.5 parts of honeysuckle, 2.5 parts of balloonflower root, 2.5 parts of Radix Angelicae Sinensis, 2.5 parts of matrimony vine.
4. the composition with relieving sore-throat antiinflammation described in any one of claims 1 to 3, it is characterised in that carry each raw material
Thing and pharmaceutically acceptable carrier is taken to be prepared into the medicine or health products of granule, capsule, tablet or pellet form.
5. the preparation method of the composition with relieving sore-throat antiinflammation described in claim 1, it is characterised in that including following step
Suddenly：
(1) parts by weight as described in claim 1 take bird's nest, plus the water of 10~50 times of amounts of bird's nest weight to soak 5~12 hours,
Then protease hydrolyzed is added, is digested 0.5~4 hour under conditions of 30~45 DEG C and pH value 4~9, is inactivated, filtering obtains swallow
Nest enzymolysis liquid, bird's nest zymolyte is obtained after drying, standby；
(2) parts by weight extracting honeysuckle, balloonflower root, Radix Angelicae Sinensis and the matrimony vine as described in claim 1, adds 6 to 15 times of amounts of medicinal material, dense
The ethanol for 30%~70% is spent, is extracted 1 to 3 time, 1 to 3 hour every time, is merged extract solution, concentrate, dry, obtain honeysuckle, tangerine
Stalk, Radix Angelicae Sinensis and wolfberry fruit extract, it is standby；
(3) step (1) bird's nest zymolyte is taken respectively, and step (2) honeysuckle, balloonflower root, Radix Angelicae Sinensis and wolfberry fruit extract are well mixed,
Add on food or pharmaceutically acceptable carrier is prepared into health products or medicine.
6. the preparation method of the composition according to claim 5 with relieving sore-throat antiinflammation, it is characterised in that step
(1) protease described in is trypsase, pepsin, neutral proteinase, flavor protease, papain or compound protein
Enzyme.
7. the preparation method of the composition according to claim 5 with relieving sore-throat antiinflammation, it is characterised in that described
Drying means is freeze-drying, fluidized bed drying or spray drying.
8. the preparation method of the composition according to claim 5 with relieving sore-throat antiinflammation, it is characterised in that step
(1) temperature of enzymolysis is 37 DEG C, and pH value is 8, and enzymolysis time is 3 hours.
9. the composition with relieving sore-throat antiinflammation described in any one of claims 1 to 3 is in anti-sphagitis medicine is prepared
Using.
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| CN108576545A (en) * | 2018-05-24 | 2018-09-28 | 刘树民 | A kind of bird's nest effervescent tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102771852A (en) * | 2011-12-31 | 2012-11-14 | 厦门市丝浓食品有限公司 | Sialic acid beverage and making method thereof |
| CN103083539A (en) * | 2012-12-27 | 2013-05-08 | 王吉坤 | Chinese herbal compound for treating common respiratory system diseases |
| CN103394020A (en) * | 2013-08-03 | 2013-11-20 | 赵彦琦 | Composition used for treating cough |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102771852A (en) * | 2011-12-31 | 2012-11-14 | 厦门市丝浓食品有限公司 | Sialic acid beverage and making method thereof |
| CN103083539A (en) * | 2012-12-27 | 2013-05-08 | 王吉坤 | Chinese herbal compound for treating common respiratory system diseases |
| CN103394020A (en) * | 2013-08-03 | 2013-11-20 | 赵彦琦 | Composition used for treating cough |
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