CN105029392A

CN105029392A - Medical formula food for nasopharynx cancer

Info

Publication number: CN105029392A
Application number: CN201510162508.6A
Authority: CN
Inventors: 陈昕; 秦孝发; 吴�灿; 胡安然; 蔡缨
Original assignee: Jing Shanmei Biotech Inc
Current assignee: Jing Shanmei Biotech Inc
Priority date: 2015-04-08
Filing date: 2015-04-08
Publication date: 2015-11-11

Abstract

The invention belongs to the technical field of affinal-drug-and-diet formulas and new-resource foods, and particularly provides a medical formula food, a special medical formula food or a non-special medical formula food for nasopharynx cancer patients. The formula is designed according to the requirement in "National Food Safety Standard General Rules on Formula Food for Special Medical Use". With consideration of the body characters of the nasopharynx cancer patients, various "affinal-drug-and-diet" traditional Chinese medicines are combined reasonably according to traditional Chinese medicine essential principles, and a plurality of affinal-drug-and-diet traditional Chinese medicine extract essences which are extracted through a pre-hydrolysis SBE technology, various micro-capsulated probiotics, oligopeptides extracted through bio-enzymolysis, prebiotics, amino acids, carbohydrates, grease having health-caring functions, various vitamins and minerals are all mixed together and are subjected to other processes to obtain the medical formula food. The medical formula food can be used for satisfying nutrition requirement of the nasopharynx cancer patients as a single nutritional source, and has the functions of nourishing yin and clearing heat, boosting qi and soothing throat, tonifying and boosting qi and blood, harmonizing ying and removing toxin, softening hardness and dissipating binds, and enhancing body immunity.

Description

Nasopharyngeal carcinoma medical science formula food

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and new resource food technical field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds with small peptide, prebiotics, amino acid, carbohydrate, the nasopharyngeal carcinoma medical science formula food, certain medical formula food or the non-medical formula food that have the grease of health care, B B-complex, composite mineral matter to make for auxiliary material.

Background technology

Nasopharyngeal carcinoma refers to the malignant tumour originating from nasopharyngeal mucosal epithelium and body of gland, often betide the top of nasopharynx top rear wall, secondly be sidewall, betide antetheca and diapire person is extremely rare, age of onset is mostly a middle-aged person, also teenager is had to suffer from patient, the nasopharyngeal carcinoma origin cause of formation: inherent cause, race's neurological susceptibility nasopharyngeal carcinoma mainly betides yellow, with Asia South Pacific region, country is many, live in and lowly send out overseas Chinese regional and descendant still keeps tendency occurred frequently, there is family history person comparatively common in aggregation Nasopharyngeal Carcinoma Patients, virus infections, that thinks Epstein-Barr virus and nasopharyngeal carcinoma has substantial connection more, but Epstein-Barr virus is extensively present in crowd all over the world, and nasopharyngeal carcinoma has obvious region, illustrate that ebv infection is not the only factor that nasopharyngeal carcinoma is caused a disease, environmental factor, can be relevant with number of chemical carcinogen, as nitrosamines and microelement nickel etc., in addition, hypovitaminosis, gonadal hormone disturbances etc. all can change mucous membrane to carcinogenic sensitiveness, nasopharyngeal carcinoma adopts the mode of parenteral nutrition (namely inputting nutritional drugs) to carry out nutritional supplementation to cancer patient clinically more, and long-term parenteral nutrition supplements and easily causes enteron aisle Villus atrophy, and accompanying infection, thus increases the weight of the harm to body, " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science, the traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet, allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery,

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard traditional Chinese medicine food clear stipulaties: 2.1.1 medical science formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 certain medical formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition;

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively;

The relation of nasopharyngeal carcinoma and Tiny ecosystem: 32 routine Patients with Nasopharyngeal Carcinoma in Radiation Therapies, saliva sample is gathered at irradiation area mucous membrane respectively before and after radiotherapy, carry out the separation culture identification of bacterium, measure the recall rate of cultivable bacteria, detected level and constituent ratio, result: compared with before radiotherapy, after radiotherapy, the streptococcus of irradiation area, staphylococcus, Candida albicans and Pseudomonas aeruginosa detect increase; And actinomyces and neisseria detect minimizing, and (P0.05, conclusion: nasopharyngeal carcinoma radiotherapy can affect pharyngeal microecological balance are that after causing nasopharyngeal carcinoma radiotherapy, one of major reason infected occurs patient;

Though direct probiotic oral has certain effect, but due to probio cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by the key technology research to probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and inulin and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis,

Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with Nasopharyngeal Carcinoma Patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin, several mineral materials is the medical science formula food that auxiliary material is made, certain medical formula food or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by the probio of multiple raising Nasopharyngeal Carcinoma Patients immunity and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, there is the grease of health care, multivitamin, several mineral materials is auxiliary material, the Nasopharyngeal Carcinoma Patients institute essential nutrients of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the medical science formula food that the acceptable applicable Nasopharyngeal Carcinoma Patients of people is edible, certain medical formula food or non-medical formula food.

summary of the invention:

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", the constitutive character of the Nasopharyngeal Carcinoma Patients that binding immunoassay power is low, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt Chinese medical extract elite and the new resource food of one or more medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets Nasopharyngeal Carcinoma Patients, nourishing Yin and clearing heat in addition, benefit gas relieve sore throat, tonifying Qi and blood, with battalion's removing toxic substances, the medical science formula food of effect of softening and resolving hard mass and develop immunitypty, certain medical formula food or non-medical formula food (compound prescription be combined into),

1, the main component of the present invention's formula is:

Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of nasopharyngeal carcinoma, utilizes the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and chooses following several large class medicine and carry out compatibility; Wherein: gynostemma pentaphylla nature and flavor: bitter; Micro-sweet; Cool in nature; Effect: replenish qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, clearing heat and detoxicating; Stem of noble dendrobium slightly sweet flavor is micro-salty, cold, returns stomach, kidney, lung channel.Reinforcing stomach reg fluid, nourishing Yin and clearing heat, the fruit of Chinese magnoliavine is astringed the lung, and nourshing kidney is promoted the production of body fluid, and receive sweat, puckery essence, saline cistanche taste is sweet, warm in nature, the effect such as have tonifying kidney and strengthening yang, Tianjing Busuiye medicinal, enriching the blood to restore normal menstruation, happy look are prolonged life, and the root of bidentate achyranthes is raw with loose hemostasis, subduing inflammation, and rhizoma cyperi is regulated the flow of vital energy Xie Yu; Menstruction regulating and pain relieving; Antiabortive, rhizoma alismatis Li Shui, excreting dampness, expels the heat-evil, radix scrophulariae clearing heat and cooling blood; Nourishing Yin and falling fire; Detoxicating and resolving a mass; Balloonflower root a surname lung, relieve sore throat, eliminates the phlegm, apocenosis; The root of herbaceous peony is cool in nature, and bitter acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, when attribution have enrich blood invigorate blood circulation, effect of swelling and pain relieving, apocenosis myogenic, therefore can be used for the card such as traumatic injury, ulcer sores; Dandelion is clearing heat and detoxicating, diuresis dissipating bind; The root of Dahurain angelica is used as medicine with root, the functions such as the dehumidifying that gets rid of illness, apocenosis myogenic, promoting blood circulation and stopping pain; Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as the disease such as body heat, dermexanthesis, spot, hot carbuncle carbuncle, abscess of throat, and equal Be very effective; Lily has Yin nourishing and lung moistening; Effect of clearing away the heart fire and tranquillizing;

Medicinal and edible Chinese medicine extract of the present invention refers to the stem of noble dendrobium, Cordyceps sinensis (aweto mycelium), lucidum spore powder (broken wall), glossy ganoderma, gynostemma pentaphylla, the stem of noble dendrobium, the fruit of Chinese magnoliavine, the Radix Astragali, Radix Codonopsis, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the root of herbaceous peony, saline cistanche, the root of bidentate achyranthes, rhizoma cyperi, rhizoma alismatis, radix scrophulariae, Cordyceps militaris, balloonflower root, dandelion, almond, the root of Dahurain angelica, honeysuckle, jujube, radix polygonati officinalis, reed rhizome, lily, sealwort, chrysanthemum, cape jasmine, kelp, marine alga, peppermint, fructus alpiniae oxyphyllae, the leaf of bamboo, peach kernel, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, selfheal, Qingqian Willow leaf, Tea Flower, Guangdong Cordyceps militaris, yeast beta-dextran, tealeaves theanine, Saussurea involucrata culture, breast mineral salt, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa one wherein, several or whole, adopt biological enzymolysis or prehydrolysis SBE to extract and microencapsulation, the mixture after spray-dried and cryodesiccated extract,

2, multiple probio: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, builds up resistance;

Multiple probio of the present invention all adopts the probio after microencapsulation, and the probio described in it is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici are wherein a kind of, several or all mix;

Bifidobacterium above a refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above b refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri;

3, small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix;

4, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, stimulate enterocinesia to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of enhancing nasopharyngeal carcinoma resistance;

Prebiotics of the present invention is 2 classes

A. have very strong field planting effect prebiotics to external source probio: Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin extract;

B. common prebiotics: oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide, cotton seed compound sugar, trehalose, stachyose, yeast;

Prebiotics of the present invention is: the extract of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide, trehalose, one wherein, several or all mix;

5, carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix;

6. there is the grease of health care to refer to there is health-care effect to the person, and finished product energy can be increased, make the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal); As the street cleaner that fish oil is human vas, can also prevention of arterial sclerosis, apoplexy and heart disease.Fish oil is the diseases such as hypertension, coronary heart disease, headstroke, diabetes, rheumatic arthritis, cancer; Linseed oil has fat-reducing, reduces cholesterol, improves the effects such as renal function; Peony seed oil has reducing blood lipid and hypotensive, strengthens autoimmunity, prevention diabetes, effect of anti-curing cancers; Samara oil prevents and treats hypertension, high fat of blood, effect of the illnesss such as vascular sclerosis;

Of the present invention have the grease of health care to refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix,

7. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix;

8. vitamin and mineral matter: vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals is with reference to GB14880 " food enrichment use sanitary standard ", GB2760 " food additives use standard " performs, now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product strengthen nasopharyngeal carcinoma resistance significantly improves compared with the like product of market;

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

The characteristic of this formula medical science formula food and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of Nasopharyngeal Carcinoma Patients, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility;

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is adopted to be primary raw material, with prebiotics, carbohydrate, the grease having health care, amino acid, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect;

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb fast, completely, Nasopharyngeal Carcinoma Patients desired nutritional can be supplemented rapidly;

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, there is the effect strengthening resistance of human body, nourishing Yin and clearing heat in addition, benefit gas relieve sore throat, tonifying Qi and blood, and battalion's removing toxic substances, effect of softening and resolving hard mass and develop immunitypty;

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced,

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve Nasopharyngeal Carcinoma Patients negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa;

7. this prescription have employed this team by the achievement to probio key technology research of field planting mechanism in enteron aisle over nearly 3 year, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio;

8. prebiotics contained in the present invention's formula, by promoting the growth and breeding of probio in intestines, suppress the growth of spoilage organisms, form one protective barrier at intestinal mucosal surface simultaneously, the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted, reduce the absorption of intestinal toxic material, intestines peristalsis can also be promoted, accelerate the discharge of residuals in intestines, constipation can be prevented, and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy;

9, in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

10. in the present invention's formula, the contained grease of health care that has not only has health-care effect to the person, and provides the energy needed for normal life for human body, makes the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal);

11, contained in the present invention's formula amino acid, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development;

12, formula food of the present invention is containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for Nasopharyngeal Carcinoma Patients, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element;

13, not fatty and cholesterol in the present invention's formula, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following case study on implementation, the invention will be further described, and it will contribute to understanding the present invention.

Case study on implementation one

Realizing the object of the invention nasopharyngeal carcinoma medical science formula food is constitutive character in conjunction with Nasopharyngeal Carcinoma Patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease multivitamin of health care, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: stem of noble dendrobium 12g, Cordyceps sinensis (aweto mycelium) 12g, lucidum spore powder (broken wall) 12g, glossy ganoderma 11g, gynostemma pentaphylla 11g, stem of noble dendrobium 10g, fruit of Chinese magnoliavine 10g, Radix Astragali 10g, Radix Codonopsis 9g, bighead atractylodes rhizome 9g, Radix Angelicae Sinensis 9g, root of herbaceous peony 8g, saline cistanche 8g, root of bidentate achyranthes 8g, rhizoma cyperi 8g, rhizoma alismatis 8g, radix scrophulariae 7g, Cordyceps militaris 7g, balloonflower root 7g, dandelion 7g, almond 7g, root of Dahurain angelica 7g, honeysuckle 6g, jujube 6g, radix polygonati officinalis 6g, reed rhizome 6g, lily 6g, sealwort 6g, chrysanthemum 6g, cape jasmine 5g, kelp 5g, marine alga 5g, peppermint 5g, fructus alpiniae oxyphyllae 5g, leaf of bamboo 5g, peach kernel 5g, line leaf broom top 5g, eucommia Bark male flower 4g, Euglena 4g, phoenix peony 4g, combined spicebush leaf 4g, leaf of Moringa 3g, Noni fruit 3g, Acerola cherry fruit 3g, Opuntia ficus 3g, Leaves of Hippophae L 3g, it shellfish 2g, cynanchum auriculatum Royle 2g, selfheal 2g, Qingqian Willow leaf 2g, Tea Flower 1g, the sub-1g of Guangdong Cordyceps militaris, yeast beta-dextran 5g, tealeaves theanine 3g, Saussurea involucrata culture 3g, breast mineral salt 2g, currant lobate layer bacterium fermentation mycelium 2g, chlorella pyrenoidosa 1g, multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

First will to be the stem of noble dendrobium during making, glossy ganoderma, gynostemma pentaphylla, the stem of noble dendrobium, the fruit of Chinese magnoliavine, the Radix Astragali, Radix Codonopsis, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the root of herbaceous peony, saline cistanche, the root of bidentate achyranthes, rhizoma cyperi, rhizoma alismatis, radix scrophulariae, balloonflower root, dandelion, the root of Dahurain angelica, honeysuckle, jujube, radix polygonati officinalis, reed rhizome, lily, sealwort, chrysanthemum, cape jasmine, kelp, marine alga, peppermint, fructus alpiniae oxyphyllae, the leaf of bamboo, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, selfheal, Qingqian Willow leaf, Tea Flower soak after add cycloheptaamylose, with prehydrolysis SBE technology extract after, spray-dried and preparation flour, then add biological enzymolysis extract lucidum spore powder (broken wall), almond, peach kernel, Cordyceps sinensis (aweto mycelium), Cordyceps militaris, Guangdong Cordyceps militaris, yeast beta-dextran, tealeaves theanine, Saussurea involucrata culture, breast mineral salt, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa, small peptide, prebiotics, amino acid, carbohydrate, there is the grease of health care, carry out pasteurization after multivitamin and mineral matter are pulverized and mixed together 1 hour, then add the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus also mixes the solid beverage making powdery, granule, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require,

Manufacture craft of the present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat nasopharyngeal carcinoma significantly improves compared with the like product of market.

Case study on implementation two

Above-mentioned nasopharyngeal carcinoma medical science formula food also comprises following component by weight, the extract of medicine-food two-purpose: Cordyceps militaris 7g, balloonflower root 7g, dandelion 7g, almond 7g, root of Dahurain angelica 7g, honeysuckle 6g, jujube 6g, radix polygonati officinalis 6g, reed rhizome 6g, lily 6g, sealwort 6g, chrysanthemum 6g, cape jasmine 5g, kelp 5g, marine alga 5g, peppermint 5g, fructus alpiniae oxyphyllae 5g, leaf of bamboo 5g, peach kernel 5g, line leaf broom top 5g, eucommia Bark male flower 4g, Euglena 4g, phoenix peony 4g, combined spicebush leaf 4g, leaf of Moringa 3g, Noni fruit 3g, Acerola cherry fruit 3g, Opuntia ficus 3g, Leaves of Hippophae L 3g, it shellfish 2g, cynanchum auriculatum Royle 2g, selfheal 2g, Qingqian Willow leaf 2g, Tea Flower 1g, the sub-1g of Guangdong Cordyceps militaris, yeast beta-dextran 5g, tealeaves theanine 3g, Saussurea involucrata culture 3g, breast mineral salt 2g, currant lobate layer bacterium fermentation mycelium 2g, chlorella pyrenoidosa 1g,

Prebiotics 350g, probio 300g, small peptide 150g, several amino acids 100g, carbohydrate 100g, the grease 100g having health care, water-soluble dietary fiber 50g, vitamin and mineral matter 25g.

Case study on implementation three

Above-mentioned nasopharyngeal carcinoma medical science formula food also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation four

The certain medical formula food of above-mentioned nasopharyngeal carcinoma also comprises following component by weight: prebiotics 700g, small peptide 500g, carbohydrate 300g, multiple probio 300g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation five

Above-mentioned nasopharyngeal carcinoma medical science formula food also comprises following component by weight: prebiotics 500g, small peptide 350g, carbohydrate 300g, multiple probio 250g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation six

Above-mentioned nasopharyngeal carcinoma medical science formula food also comprises following component by weight: small peptide 350g, prebiotics 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Claims

1. nasopharyngeal carcinoma medical science formula food, it is characterized in that the constitutive character in conjunction with Nasopharyngeal Carcinoma Patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease of health care, multivitamin, several mineral materials to make for auxiliary material;

Manufacture craft of the present invention is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat nasopharyngeal carcinoma significantly improves compared with the like product of market.

2. nasopharyngeal carcinoma medical science formula food according to claim 1, is characterized in that described medicine-food two-purpose Chinese herbal medicine extract and new resource food are: the stem of noble dendrobium, glossy ganoderma, gynostemma pentaphylla, the stem of noble dendrobium, the fruit of Chinese magnoliavine, the Radix Astragali, Radix Codonopsis, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the root of herbaceous peony, saline cistanche, the root of bidentate achyranthes, rhizoma cyperi, rhizoma alismatis, radix scrophulariae, balloonflower root, dandelion, the root of Dahurain angelica, honeysuckle, jujube, radix polygonati officinalis, reed rhizome, lily, sealwort, chrysanthemum, cape jasmine, kelp, marine alga, peppermint, fructus alpiniae oxyphyllae, the leaf of bamboo, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, selfheal, Qingqian Willow leaf, Tea Flower soak after add cycloheptaamylose, with prehydrolysis SBE technology extract after, spray-dried and preparation flour, then add biological enzymolysis extract lucidum spore powder (broken wall), almond, peach kernel, Cordyceps sinensis (aweto mycelium), Cordyceps militaris, Guangdong Cordyceps militaris, yeast beta-dextran, tealeaves theanine, Saussurea involucrata culture, breast mineral salt, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa one wherein, several or all mix.

3. nasopharyngeal carcinoma medical science formula food according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. nasopharyngeal carcinoma medical science formula food according to claim 1, also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

5. nasopharyngeal carcinoma medical science formula food according to claim 1, is characterized in that described probio is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici, wherein a kind of, several or all mix;

Bifidobacterium above refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri.

6. nasopharyngeal carcinoma medical science formula food according to claim 1, it is characterized in that described prebiotics is: the extraction mixture of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, trehalose, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix.

7. nasopharyngeal carcinoma medical science formula food according to claim 1, is characterized in that described amino acid is: Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

8. the medical science formula food of nasopharyngeal carcinoma according to claim 1, is characterized in that described carbohydrate is that carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

9. nasopharyngeal carcinoma medical science formula food according to claim 1, it is characterized in that the described grease of health care that has is: refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix.

10. nasopharyngeal carcinoma medical science formula food according to claim 1, is characterized in that described small peptide is: marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.