CN104323240A

CN104323240A - Full-nutrition formula food for colorectal cancer

Info

Publication number: CN104323240A
Application number: CN201410559791.1A
Authority: CN
Inventors: 胡安然
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-10-21
Filing date: 2014-10-21
Publication date: 2015-02-04

Abstract

The invention provides a full-nutrition formula food, a specific full-nutrition formula food or a non-full-nutrition formula food for colorectal cancer patients to eat. According to the formula, the food is prepared by combining constitutive characters of the colorectal cancer patients according to the requirements of General Principles of Formula Food for Special Medical Application, and comprehending research results of current advanced physiology, medicine, nutriology, clinical application and the like of Harvard University according to the essential theory (taking homology of liver, spleen and kidney as the main principle) of traditional Chinese medicine of promoting splenic diabetes and tonifying, and balancing and recuperating. The product is prepared by taking extract essence of a plurality of traditional Chinese medicines being used as both medicines and foods, a plurality of probiotics and oligopeptides as main raw materials and taking prebiotics, carbohydrates, amino acids, a plurality of vitamins and mineral substances as auxiliary materials through mixing; and the food can be used as a single nutrition source to meet the nutritional requirements of the colorectal cancer patients and also has the effects of clearing heat and promoting diuresis, purging guts and eliminating stagnation, promoting qi to activate blood, tonifying the spleen and kidney, tonifying qi and inducing astringency, supporting the healthy energy and enhancing immunity.

Description

The full nutritional formulas of colorectal cancer

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and food technology field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds the full nutritional formulas of colorectal cancer, specific full nutritional formulas or the non-fully nutritional formulas made for auxiliary material with small peptide, prebiotics, amino acid, carbohydrate, B B-complex, composite mineral matter.

Background technology

Colorectal cancer is one of common malignant tumour, and comprising the performance such as the carcinoma of the rectum, colon cancer, is affect the healthy important diseases of people one of,colorectal cancer is difficult toward visiting course of disease delay clinically, syndrome is intricate, cold and heat and asthenia and sthenia is held concurrently and is pressed from both sides, colorectal cancer is the general name of colon cancer and the carcinoma of the rectum, colorectal cancer refers to the malignant change prognosis mala that colorectal mucosa epithelium occurs under the multiple carcinogenic factor effect such as environment or heredity, the death rate is higher, colorectal cancer is the malignant tumour of colorectal mucosa epithelium genesis, it is one of modal malignant tumor of digestive tract, the colorectal cancer origin cause of formation: the generation of colorectal cancer and higher fatty acid low cellulose diet, large intestine chronic inflammation, Colorectal Adenomas, inherent cause and other factors are as snail fever, pelvic cavity radiates, environmental factor, smoking etc. are relevant, and the unbalance IBD of causing of enteric microorganism is the important factor bringing out intestinal tract, colorectal cancer adopts the mode of parenteral nutrition (namely inputting nutritional drugs) to carry out nutritional supplementation to cancer patient clinically more, and long-term parenteral nutrition supplements and easily causes enteron aisle Villus atrophy, and accompanying infection, thus increases the weight of the harm to body, " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science, the traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet, allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery.

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And the full nutritional formulas of wholefood clear stipulaties: 2.1.1 in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 specific full nutritional formulas: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition.

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium Bifidum accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively.

The relation of colorectal cancer and Tiny ecosystem: when beneficial bacteria of intestinal tract (as Bifidobacterium, lactobacillus etc.) is not in the ascendance, a large amount of harmful bacteria can produce the carcinogen such as nitrosamine, phenols, the toxin that direct long term contact various bacteria produces can cause intestinal mucosa inflammation, brings out colorectal cancer.

Though direct probiotic oral has certain effect, but due to probio one cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by studying the key technology of probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and jerusalem artichoke and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis.

Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with PATIENTS WITH LARGE BOWEL, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials is the full nutritional formulas that auxiliary material is made, specific full nutritional formulas or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by the probio of multiple raising PATIENTS WITH LARGE BOWEL immunity and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, multivitamin, several mineral materials is auxiliary material, the PATIENTS WITH LARGE BOWEL institute essential nutrients of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the full nutritional formulas that the acceptable applicable PATIENTS WITH LARGE BOWEL of people is edible, specific full nutritional formulas or non-fully nutritional formulas.

summary of the invention:

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", the constitutive character of the PATIENTS WITH LARGE BOWEL that binding immunoassay power is low, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt the Chinese medical extract elite of more than 4 kinds medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets PATIENTS WITH LARGE BOWEL, also has clearing heat and promoting diuresis, gut purge dissipating bind, the promoting flow of qi and blood circulation, tonifying spleen and kidney, benefit gas-solid is puckery, strengthen the body resistance to consolidate the constitution and the full nutritional formulas of effect of develop immunitypty, specific full nutritional formulas or non-fully nutritional formulas (compound prescription be combined into).

1, the main component of the present invention's formula is:

Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of colorectal cancer, utilizes the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and chooses following several large class medicine and carry out compatibility; Wherein: the stem of noble dendrobium, reinforcing stomach reg fluid is nourishing Yin and clearing heat; The banksia rose, promoting the circulation of qi, pain relieving, invigorating the spleen, helps digestion; The bark of official magnolia, promoting the circulation of qi disappears long-pending, and eliminating dampness is except full; Relieving asthma; The Radix Astragali, it has enhanced machine body immunity function, protects the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely; Radix Codonopsis, has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung; The red sage root, has stasis-dispelling and pain-killing, activating blood to promote menstruation, the effect of the relieving restlessness that clears away heart-fire; The tuber of dwarf lilyturf, nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire; The bighead atractylodes rhizome, has strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive effect; Cordyceps militaris, Chinese caterpillar fungus enters lung kidney two warp, can tonifying lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, weak after being ill, chronic cough is weak, phthisical cough phlegm blood, and spontaneous sweating etc. are unique a kind of Chinese medicine that can balance simultaneously, regulate negative and positive; Coix seed, invigorating the spleen excreting dampness, except numbness antidiarrheal; Purslane, clearing heat and detoxicating, loose blood detumescence; Poria cocos, has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative; Honeysuckle, has clearing heat and detoxicating, that anti-inflammatory, qi-restoratives treat wind effect; Fig, invigorating stomach and promoting bower movements, subdhing swelling and detoxicating; Hawthorn, spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting; Raspberry, has improving eyesight, kidney tonifying functions; Dried orange peel, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm; Fructus amomi, promoting the circulation of qi seasoning, and stomach is amusing;

Medicinal and edible Chinese medicine extract of the present invention refers to Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,glossy ganoderma, the banksia rose, the bark of official magnolia, the Radix Astragali, Radix Codonopsis, the red sage root, rheum officinale, the tuber of dwarf lilyturf, radix pseudostellariae, the bighead atractylodes rhizome, Radix Angelicae Sinensis, safflower, the fruit of Chinese magnoliavine, selfheal, Cordyceps militaris, coix seed, purslane, Poria cocos, honeysuckle, fig, hawthorn, raspberry, dried orange peel, fructus amomi, Fructus Hordei Germinatus, Radix Glycyrrhizae, Buddha's hand, peach kernel, Radix et Rhizoma Gynurae divaricatae, dark plum, cape jasmine, cordate houttuynia, nutmeg, dandelion, the membrane of a chicken's gizzard, Hericium erinaceus, sea-buckthorn, radish seed, pawpaw, the fruit of Chinese wolfberry, almond, sealwort wherein more than 4 kinds or all, biological enzymolysis or prehydrolysis SBE is adopted to extract and microencapsulation, mixture after spray-dried and cryodesiccated extract.

2, multiple probio: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, builds up resistance;

Multiple probio of the present invention all adopts the probio after microencapsulation, except streptococcus thermophilus, wherein Bifidobacterium: refer to that bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum are wherein a kind of, several or all mix; Lactobacillus refers to: lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus are wherein a kind of, several or all mix.

3, small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.

4, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, stimulate enterocinesia to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of enhancing colorectal cancer resistance;

Prebiotics of the present invention is 2 classes

A. very strong field planting effect prebiotics is had to external source probio: the extract of Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, jerusalem artichoke, stachyose, yeast wherein several or all mix;

B. common prebiotics: oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;

Originally oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix is referred to.

5, carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

6. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

7. vitamin and mineral matter:

Vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.

8. the present invention is with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product strengthen colorectal cancer resistance significantly improves compared with the like product of market.

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.

The characteristic of this full nutritional formulas of filling a prescription and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of PATIENTS WITH LARGE BOWEL, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility.

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is adopted to be primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect.

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb fast, completely, PATIENTS WITH LARGE BOWEL desired nutritional can be supplemented rapidly.

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, there is the effect strengthening resistance of human body, also have clearing heat and promoting diuresis, gut purge dissipating bind, the promoting flow of qi and blood circulation, tonifying spleen and kidney, beneficial gas-solid is puckery, strengthen the body resistance to consolidate the constitution and effect of develop immunitypty.

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced.

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve PATIENTS WITH LARGE BOWEL negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa.

7. this prescription have employed this team by over nearly 3 year to the achievement that the key technology of probio field planting mechanism in enteron aisle is studied, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio.

8. prebiotics contained in the present invention's formula; by promoting the growth and breeding of probio in intestines; suppress the growth of spoilage organisms; form one protective barrier at intestinal mucosal surface simultaneously; the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted; reduce the absorption of intestinal toxic material; intestines peristalsis can also be promoted; accelerate the discharge of residuals in intestines; constipation can be prevented; and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy.

9, in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce.

10, contained in the present invention's formula amino acid, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development.

11, formula food of the present invention is containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for PATIENTS WITH LARGE BOWEL, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element.

12, not fatty and cholesterol in the present invention's formula, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following examples, the invention will be further described, and it will contribute to understanding the present invention.

Embodiment one

Realizing the full nutritional formulas of the object of the invention colorectal cancer is constitutive character in conjunction with PATIENTS WITH LARGE BOWEL, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the Chinese medical extract elite of more than 4 kinds medicine-food two-purposes, multiple probio, small peptide for primary raw material, the food made for auxiliary material with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials;

Fill a prescription by following raw materials according and consumption thereof: the extract of medicine-food two-purpose: Cordyceps sinensis (aweto mycelium) 8g, stem of noble dendrobium 8g, lucidum spore powder (broken wall) 8g ,glossy ganoderma 8g, banksia rose 8g, bark of official magnolia 8g, Radix Astragali 8g, Radix Codonopsis 8g, red sage root 6g, rheum officinale 6g, the tuber of dwarf lilyturf 6g, radix pseudostellariae 6g, bighead atractylodes rhizome 6g, Radix Angelicae Sinensis 6g, safflower 6g, fruit of Chinese magnoliavine 6g, selfheal 6g, Cordyceps militaris 6g, coix seed 4g, purslane 4g, Poria cocos 4g, honeysuckle 4g, fig 4g, hawthorn 4g, raspberry 4g, dried orange peel 4g, fructus amomi 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g, Buddha's hand 2g, peach kernel 2g, Radix et Rhizoma Gynurae divaricatae 2g, dark plum 2g, cape jasmine 2g, cordate houttuynia 2g, nutmeg 2g, dandelion 2g, the membrane of a chicken's gizzard 2g, Hericium erinaceus 2g, sea-buckthorn 2g, radish seed 2g, pawpaw 2g, fruit of Chinese wolfberry 2g, almond 2g, sealwort 2g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

First will to be glossy ganoderma during making, the banksia rose, the bark of official magnolia, the Radix Astragali, Radix Codonopsis, the red sage root, rheum officinale, the tuber of dwarf lilyturf, radix pseudostellariae, the bighead atractylodes rhizome, Radix Angelicae Sinensis, safflower, the fruit of Chinese magnoliavine, selfheal, purslane, honeysuckle, fig, hawthorn, raspberry, dried orange peel, fructus amomi, Fructus Hordei Germinatus, Radix Glycyrrhizae, Buddha's hand, Radix et Rhizoma Gynurae divaricatae, dark plum, cape jasmine, cordate houttuynia, nutmeg, dandelion, Hericium erinaceus, sea-buckthorn, radish seed, pawpaw, the fruit of Chinese wolfberry, almond, sealwort, the membrane of a chicken's gizzard, Chinese yam, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,carbohydrate, Cordyceps militaris, multivitamin and mineral matter are pulverized together and are carried out pasteurization 1 hour after adding Poria cocos, peach kernel, coix seed, mixing, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.

Embodiment two

The full nutritional formulas of above-mentioned colorectal cancer also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 10g, coix seed 10g, purslane 10g, Poria cocos 10g, honeysuckle 10g, fig 10g, hawthorn 10g, raspberry 8g, dried orange peel 8g, fructus amomi 8g, Fructus Hordei Germinatus 8g, Radix Glycyrrhizae 8g, Buddha's hand 8g, Radix et Rhizoma Gynurae divaricatae 8g, dark plum 8g, cape jasmine 6g, cordate houttuynia 6g, peach kernel 6g, nutmeg 6g, dandelion 6g, the membrane of a chicken's gizzard 6g, Hericium erinaceus 6g, sea-buckthorn 4g, radish seed 4g, pawpaw 4g, fruit of Chinese wolfberry 4g, almond 4g, sealwort 4g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.

Embodiment three

The full nutritional formulas of above-mentioned colorectal cancer also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 10g, coix seed 10g, purslane 10g, Poria cocos 10g, honeysuckle 10g, fig 10g, hawthorn 10g, raspberry 8g, dried orange peel 8g, fructus amomi 8g, Fructus Hordei Germinatus 8g, Radix Glycyrrhizae 8g, Buddha's hand 8g, Radix et Rhizoma Gynurae divaricatae 8g, dark plum 8g, cape jasmine 6g, cordate houttuynia 6g, peach kernel 6g, nutmeg 6g, dandelion 6g, the membrane of a chicken's gizzard 6g, Hericium erinaceus 6g, sea-buckthorn 4g, radish seed 4g, pawpaw 4g, fruit of Chinese wolfberry 4g, almond 4g, sealwort 4g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, carbohydrate 150g, prebiotics 100g, several amino acids 100g.

Embodiment four

The full nutritional formulas of above-mentioned colorectal cancer also comprises following component by weight: small peptide 350g, several amino acids 150g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, carbohydrate 100g, prebiotics 100g, B B-complex and mineral matter 50g; Energy contained by every 100 g should be not less than 295 kJ (70 kcal).

The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product improve PATIENTS WITH LARGE BOWEL immunity significantly improves compared with the like product of market.

Claims

1. the full nutritional formulas of colorectal cancer, it is characterized in that the constitutive character in conjunction with PATIENTS WITH LARGE BOWEL, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the Chinese medical extract elite of more than 4 kinds medicine-food two-purposes, multiple probio, small peptide for primary raw material, the food made for auxiliary material with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials;

Its preparation method is first will to be glossy ganoderma, the banksia rose, the bark of official magnolia, the Radix Astragali, Radix Codonopsis, the red sage root, rheum officinale, the tuber of dwarf lilyturf, radix pseudostellariae, the bighead atractylodes rhizome, Radix Angelicae Sinensis, safflower, the fruit of Chinese magnoliavine, selfheal, purslane, honeysuckle, fig, hawthorn, raspberry, dried orange peel, fructus amomi, Fructus Hordei Germinatus, Radix Glycyrrhizae, Buddha's hand, Radix et Rhizoma Gynurae divaricatae, dark plum, cape jasmine, cordate houttuynia, nutmeg, dandelion, Hericium erinaceus, sea-buckthorn, radish seed, pawpaw, the fruit of Chinese wolfberry, almond, sealwort, the membrane of a chicken's gizzard, Chinese yam, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,carbohydrate, Cordyceps militaris, multivitamin and mineral matter pulverize together and add Poria cocos, peach kernel, coix seed mixing after carry out pasteurization 1 hour, then the various batchings that the Bifidobacterium after adding microencapsulation, lactobacillus, streptococcus thermophilus also add appropriate carbohydrate mixing again mix solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.

2. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterized in that described medicine-food two-purpose Chinese herbal medicine extract is: Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,glossy ganoderma, the banksia rose, the bark of official magnolia, the Radix Astragali, Radix Codonopsis, the red sage root, rheum officinale, the tuber of dwarf lilyturf, radix pseudostellariae, the bighead atractylodes rhizome, Radix Angelicae Sinensis, safflower, the fruit of Chinese magnoliavine, selfheal, Cordyceps militaris, coix seed, purslane, Poria cocos, honeysuckle, fig, hawthorn, raspberry, dried orange peel, fructus amomi, Fructus Hordei Germinatus, Radix Glycyrrhizae, Buddha's hand, peach kernel, Radix et Rhizoma Gynurae divaricatae, dark plum, cape jasmine, cordate houttuynia, nutmeg, dandelion, the membrane of a chicken's gizzard, Hericium erinaceus, sea-buckthorn, radish seed, pawpaw, the fruit of Chinese wolfberry, almond, sealwort wherein more than 5 kinds or all mix.

3. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. the full nutritional formulas formula of colorectal cancer according to claim 1, also comprises following component by weight: small peptide 350g, several amino acids 150g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, carbohydrate 100g, prebiotics 100g, B B-complex and mineral matter 50g.

5. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterized in that described prebiotics is. have that very strong field planting effect prebiotics is Chinese yam to external source probio, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, the extract of jerusalem artichoke, stachyose, yeast and common prebiotics wherein several or all mix.

6. require the full nutritional formulas formula of the colorectal cancer described in 1, it is characterized in that described amino acid is Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

7. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterized in that described carbohydrate is Arabinose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

8. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, make product prevent and treat colorectal cancer effect and significantly improve compared with the like product of market.

9. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterized in that described vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix; Described mineral matter is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix.

10. the full nutritional formulas formula of colorectal cancer according to claim 1, is characterized in that described small peptide is marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide is wherein a kind of, several or all mix.