CN104784674B - It is a kind of to clone sick nutrient solution and preparation method thereof for treating - Google Patents
It is a kind of to clone sick nutrient solution and preparation method thereof for treating Download PDFInfo
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Abstract
The invention discloses a kind of for treating nutrient solution of clone's disease and preparation method thereof.Specifically, the active component and its dosage that are included in nutrient solution described in every 100 mL are as described below：5 ~ 10g codonopsis pilosula powders；5 ~ 10g Poria cocos powders；5 ~ 10g hydrolyzing lactoalbumin small peptides；0.3 ~ 0.8mg vitamin As；0.02 ~ 0.08mg vitamin Ds；1 ~ 5mg vitamin B1s；1 ~ 5mg vitamin B2s；1 ~ 5mg vitamin B6s；3 ~ 10mg iron；3 ~ 10mg zinc；And the physiological saline of surplus.The nutrient solution of the present invention is prepared according to patient's feature, the proportionings of various nutrients is suitable, nutrition is comprehensive, it is in good taste, have no toxic side effect, sufficient nutrition can be provided, enteron aisle burden is not aggravated, the flora and mucous membrane of different parts in gastrointestinal tract can be adjusted and repaired again, and can improved through gut muco-membranous barrier function and the absorption for the element that has additional nutrients.
Description
Technical field
The invention belongs to clinical nutriology fields, are related to a kind of for nutrient solution for the treatment of clone's disease and preparation method thereof.
Background technology
Clone's disease（Also known as Crohn disease, English name Crohn ' s disease, abbreviation CD）It is that a kind of reason is unknown
Bowl inflammatory diseases can occur, but be apt to occur in terminal ileum and right hemicolon at any position of gastrointestinal tract.The disease and slow
Property nonspecific ulcerative colitis（Ulceralive colitis, abbreviation UC）The two is referred to as inflammatory bowel disease
（Inflammatory bowel disease, abbreviation IBD）.The disease clinical manifestation for abdominal pain, diarrhea, intestinal obstruction, with fever,
The parenteral performance such as dystrophia.The course of disease is delayed more, and recurrent exerbation is not easy to effect a radical cure.The disease etiology unknown, it is doubtful with infection, heredity,
Humoral immunity and cellular immunity have certain relationship.At present, which there is no basic cure method, and many patients occur concurrently
Disease needs operative treatment, but Postoperative recurrent rate is very high.Power that the palindromia rate and extent of disease, illness are invaded, the course of disease
The factors such as extension, the growth at age are related, and the death rate also increases therewith.Sufferer often because of anorexia, chronic diarrhea and chronic disappears
The symptoms such as consumption disease and causing is become thin, anaemia, Hypoproteinemia, hypovitaminosis, calcium deficiency, osteoporosis, are a kind of no spies
Imitate the disease of digestive tract of therapy.
Intestinal dysfunction caused by clone's disease is one of most common clinical problem.At present, it has been subjected to clinician's
Most attention.The intestinal dysfunction of the sick patient of clone directly influences the nutrition of patient, barrier, is immunized, and directly influences disease
People's lapses to.When obstacle occurs for gut function, digestion and absorption function significantly declines or completely loses, this not only results in body
Nutritional deficiency, resistance decline, and can influence to clone the psychology of disease patient, make its rehabilitation slow.It can be seen that nutritional support
It is an indispensable remedy measures to intestinal dysfunction caused by clone's disease.
Since the 1980s, the advantages of enteral nutrition, is gradually realized.Research is thought, in addition to nutrition is supplied, enteral
Nutrition also has the special role for promoting intestinal mucosa growth, is conducive to intestinal function recovery.However, for gut function caused by clone's disease
The treatment of obstacle there is no effect method so far.Once someone treated clone's disease using a variety of nutrient formulations easily absorbed, although
This method can partly improve the nutrition condition of patient, but the function of intestinal canal without fundamentally improving patient, and if any careless,
The enteron aisle burden of patient can also be aggravated.Therefore, a kind of nutrient formulation for being suitable for the sick patient intestinal dysfunction for the treatment of clone is invented
Just become one of major issue that clinical nutriology needs solve.
Invention content
For the above situation, the present invention is intended to provide a kind of clone sick nutrient solution and preparation method thereof for treating, make
Clone patient with intestinal dysfunction passes through the non-drug such as the nutrient solution for taking particular formulation and relevant nutrition guide
Means improve the trophic level of patient and function of intestinal canal, improve patient's gut barrier function and body immunity, are conducive to
Patient's lapses to, and so as to improve the life quality of patient, shortens the hospital stays.
In order to achieve the above object, sick nutrient solution is cloned for treating the present invention provides a kind of, described in every 100 mL
The active component and its dosage included in nutrient solution is as described below.
5 ~ 10 g of codonopsis pilosula powder；
5 ~ 10 g of Poria cocos powder；
5 ~ 10 g of hydrolyzing lactoalbumin small peptide；
0.3 ~ 0.8 mg of vitamin A；
0.02 ~ 0.08 mg of vitamin D；
1 ~ 5 mg of vitamin B1；
1 ~ 5 mg of vitamin B2；
1 ~ 5 mg of vitamin B6；
3 ~ 10 mg of iron；
3 ~ 10 mg of zinc；
Physiological saline surplus.
Preferably, in the above-mentioned technical solutions, the codonopsis pilosula powder and Poria cocos powder pass through conventional crushing skill in the art
Art is made, wherein dry root of the Radix Codonopsis for campanulaceae of the genus codonopsis Radix Codonopsis, codonopsis pilosula var. modesta or radix codonpsis tangshen etc., and Poria cocos is bracket fungus
The dry sclerotia of section's fungi Poria cocos.
Preferably, in the above-mentioned technical solutions, the hydrolyzing lactoalbumin small peptide is lactalbumin or lactoalbumin through egg
The oligopeptides obtained after white enzyme hydrolysis concentration, includes 2 ~ 3 amino acid.
Preferably, in the above-mentioned technical solutions, the physiological saline is the aqueous sodium chloride that mass concentration is 0.85 ~ 0.9%
Liquid, preferably 0.9% sodium-chloride water solution contain 9 g sodium chloride in that is, every 1 kg aqueous solutions.
Preferably, in the above-mentioned technical solutions, the temperature of the physiological saline is 60 ~ 70 DEG C.
On the other hand, the above-mentioned method that sick nutrient solution is cloned for treatment is used to prepare the present invention provides a kind of,
Include the following steps：
（1）The dosage of active component is calculated according to the final volume of nutrient solution and is weighed；
（2）Step is sequentially added into suitable physiological saline（1）The hydrolyzing lactoalbumin small peptide of middle weighing, codonopsis pilosula powder,
Poria cocos powder, B family vitamin, vitamin A, vitamin D, iron and zinc, it is stirring while adding, obtain mixed liquor；
（3）To step（2）In in obtained mixed liquor addition physiological saline to final volume, be used for after mixing
The nutrient solution for the treatment of clone's disease.
Preferably, in the above-mentioned technical solutions, step（2）And step（3）Described in physiological saline be that mass concentration is
0.85 ~ 0.9% sodium-chloride water solution, preferably 0.9% sodium-chloride water solution contain 9 g sodium chloride in that is, every 1 kg aqueous solutions.
Preferably, in the above-mentioned technical solutions, step（2）And step（3）Described in the temperature of physiological saline be 60 ~ 70
℃。
Due to the utilization of above-mentioned technical proposal, compared with the prior art, the present invention has the following advantages：
1st, the proportioning of various nutrients is suitable in nutrient solution of the invention, and nutrition is comprehensive, while good in taste；It in addition, should
Nutrient solution is prepared, edible safety according to patient's feature, is had no toxic side effect；
2nd, for intestinal dysfunction, body nutritional deficiency and gut muco-membranous barrier dysfunction etc. caused by clone's disease,
The nutrient solution of the present invention can provide abundant nutrition, not aggravate enteron aisle burden, and can be to the bacterium of different parts in patient's gastrointestinal tract
Group and mucous membrane be adjusted and repair, make it closer to ecosystem, and can improve by gut muco-membranous barrier function and
Have additional nutrients plain absorption；
3rd, the non-drug means such as nutrient solution and nutrition guide by taking particular formulation of the present invention help to improve and clone
The intestinal dysfunction and nutrition condition of patient, this clones the life quality of sick patient to improving, and mitigates patient family, society
It is of great significance with the burden of national various aspects.
Specific embodiment
Further describe the present invention below in conjunction with specific embodiments.
Embodiment 1：For treating the nutrient solution of clone's disease（100 mL）Preparation.
Nutrient solution is prepared according to following formula：
10 g of codonopsis pilosula powder；
10 g of Poria cocos powder；
10 g of hydrolyzing lactoalbumin small peptide；
0.8 mg of vitamin A；
0.08 mg of vitamin D；
5 mg of vitamin B1；
5 mg of vitamin B2；
5 mg of vitamin B6；
10 mg of iron；
10 mg of zinc；
Physiological saline（0.9%）Add to 100 mL.
Specific steps：
1st, according to the final volume of nutrient solution（100 mL）It calculates the dosage of active component and is weighed；
2nd, to appropriate（60 mL）Physiological saline（0.9%）In sequentially add hydrolyzing lactoalbumin small peptide, codonopsis pilosula powder, Poria cocos
Powder, B family vitamin, vitamin A, vitamin D, iron and zinc, it is stirring while adding, obtain mixed liquor；
3rd, physiological saline is added in the mixed liquor obtained into step 2（0.9%）To 100 mL, used after mixing
In the nutrient solution for the treatment of clone's disease.
Embodiment 2：For treating the nutrient solution of clone's disease（100 mL）Preparation.
Nutrient solution is prepared according to following formula：
5 g of codonopsis pilosula powder；
5 g of Poria cocos powder；
5 g of hydrolyzing lactoalbumin small peptide；
0.3 mg of vitamin A；
0.02 mg of vitamin D；
1 mg of vitamin B1；
1 mg of vitamin B2；
1 mg of vitamin B6；
3 mg of iron；
3 mg of zinc；
Physiological saline（0.85%）Add to 100 mL.
Specific steps：
1st, according to the final volume of nutrient solution（100 mL）It calculates the dosage of active component and is weighed；
2nd, to appropriate（60 mL）Physiological saline（0.85%）In sequentially add hydrolyzing lactoalbumin small peptide, codonopsis pilosula powder, Fu
Siberian cocklebur powder, B family vitamin, vitamin A, vitamin D, iron and zinc, it is stirring while adding, obtain mixed liquor；
3rd, physiological saline is added in the mixed liquor obtained into step 2（0.85%）To 100 mL, used after mixing
In the nutrient solution for the treatment of clone's disease.
Embodiment 3：For treating the nutrient solution of clone's disease（100 mL）Preparation.
Nutrient solution is prepared according to following formula：
8 g of codonopsis pilosula powder；
8 g of Poria cocos powder；
8 g of hydrolyzing lactoalbumin small peptide；
0.6 mg of vitamin A；
0.05 mg of vitamin D；
3 mg of vitamin B1；
3 mg of vitamin B2；
3 mg of vitamin B6；
6 mg of iron；
6 mg of zinc；
Physiological saline（0.9%）Add to 100 mL.
Specific steps：
1st, according to the final volume of nutrient solution（100 mL）It calculates the dosage of active component and is weighed；
2nd, to appropriate（60 mL）Physiological saline（0.9%）In sequentially add hydrolyzing lactoalbumin small peptide, codonopsis pilosula powder, Poria cocos
Powder, B family vitamin, vitamin A, vitamin D, iron and zinc, it is stirring while adding, obtain mixed liquor；
3rd, physiological saline is added in the mixed liquor obtained into step 2（0.9%）To 100 mL, used after mixing
In the nutrient solution for the treatment of clone's disease.
Embodiment 4：The effect analysis of intestinal dysfunction caused by nutrient solution treatment clone's disease of the present invention.
Experimental subjects and method：
The sick patient of 15 ~ 35 years old clone of selection（Clone's disease is rare disease, and case is less）24 people（Average age 27.6 years old）, with
Machine is divided into embodiment group and control group, every group of 12 people.Embodiment group takes different ratio obtained in embodiment 1 to 3 daily
Nutrient solution 1 ~ 2 time is implemented 6 months；Control group takes the nutrient solution routinely prepared and carries out conventional nutrient guidance, and observation is compared
Two groups of symptom variation, concrete outcome are as shown in table 1.
Table 1, take particular formulation nutrient solution embodiment group compared with the therapeutic effect of control group.
As seen from the above table, the abdominal pain, diarrhea and nutrition condition of the patient of the nutrient solution of particular formulation are taken have and significantly carry
Height, the effective percentage of indices all reach more than 80%.This serial application the result shows that, take the nutrient solution clone disease disease
The symptom and nutrition condition of people, life quality all have clear improvement.
To clone, sick patient has special nutritive validity to the nutrient solution of the present invention, and having improves gut muco-membranous barrier work(
, can be had additional nutrients plain absorption.The sick patient of clone can select the nutrient solution of various dose as the case may be, as normal drink
The supplement of food.Occur that nutrient lacks and malnutritive gut muco-membranous barrier dysfunction has certain prevention to patient
And therapeutic effect, it has no toxic side effect, can take for a long time.
Claims (12)
1. application of the nutrient solution in the nutriment for being used to prepare the sick nutritional support of clone, nutrient solution is by following described in per 100mL
Component is formed：5 ~ 10g codonopsis pilosula powders；5 ~ 10g Poria cocos powders；5 ~ 10g hydrolyzing lactoalbumin small peptides；0.3 ~ 0.8mg vitamin As；0.02~
0.08mg vitamin Ds；1 ~ 5mg vitamin B1s；1 ~ 5mg vitamin B2s；1 ~ 5mg vitamin B6s；3 ~ 10mg iron；3 ~ 10mg zinc；It is remaining
It measures as physiological saline.
2. application of the nutrient solution according to claim 1 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the codonopsis pilosula powder and Poria cocos powder are made by conventional crushing technology.
3. application of the nutrient solution according to claim 2 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the Radix Codonopsis is campanulaceae of the genus codonopsis Radix Codonopsis, codonopsis pilosula var. modesta or the dry root of radix codonpsis tangshen.
4. application of the nutrient solution according to claim 2 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos.
5. application of the nutrient solution according to claim 1 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the hydrolyzing lactoalbumin small peptide is the oligopeptides that lactalbumin or lactoalbumin obtain after protease hydrolytic concentrates,
Include 2 ~ 3 amino acid.
6. application of the nutrient solution according to claim 1 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the physiological saline is the sodium-chloride water solution that mass concentration is 0.85 ~ 0.9%.
7. application of the nutrient solution according to claim 6 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the physiological saline is the sodium-chloride water solution that mass concentration is 0.9%.
8. application of the nutrient solution according to claim 1 in the nutriment for being used to prepare the sick nutritional support of clone, special
Sign is that the temperature of the physiological saline is 60 ~ 70 DEG C.
A kind of 9. method for preparing nutrient solution, it is characterised in that：Nutrient solution described in per 100mL is made of following components：5 ~ 10g parties
Join powder；5 ~ 10g Poria cocos powders；5 ~ 10g hydrolyzing lactoalbumin small peptides；0.3 ~ 0.8mg vitamin As；0.02 ~ 0.08mg vitamin Ds；1~
5mg vitamin B1s；1 ~ 5mg vitamin B2s；1 ~ 5mg vitamin B6s；3 ~ 10mg iron；3 ~ 10mg zinc；Surplus is physiological saline；
Preparation method includes the following steps：
1）The dosage of active component is calculated according to the final volume of nutrient solution and is weighed；
2）Step 1 is sequentially added into suitable physiological saline）The hydrolyzing lactoalbumin small peptide of middle weighing, codonopsis pilosula powder, Poria cocos powder,
B family vitamin, vitamin A, vitamin D, iron and zinc, it is stirring while adding, obtain mixed liquor；
3）To step 2）In in obtained mixed liquor addition physiological saline to final volume, obtain treating gram after mixing
The nutrient solution of grand disease.
10. according to the method described in claim 9, it is characterized in that, step 2）With step 3）Described in physiological saline be matter
Measure a concentration of 0.85 ~ 0.9% sodium-chloride water solution.
11. according to the method described in claim 10, it is characterized in that, step 2）With step 3）Described in physiological saline be matter
Measure a concentration of 0.9% sodium-chloride water solution.
12. according to the method described in claim 9, it is characterized in that, step 2）With step 3）Described in physiological saline temperature
It is 60 ~ 70 DEG C.
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| CN113679038B (en) * | 2021-08-31 | 2023-10-13 | 西安交通大学医学院第一附属医院 | Total nutrient diet composition suitable for Crohn disease and preparation method thereof |
Citations (5)
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| CN102894249A (en) * | 2012-09-06 | 2013-01-30 | 广东省农业科学院农业生物技术研究所 | Physical fatigue relieving nutrient liquid and preparation method thereof |
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| CN103054938A (en) * | 2013-01-31 | 2013-04-24 | 哈药集团中药二厂 | Oral preparation for conditioning stomach and intestine dysbacteriosis |
| CN104323246A (en) * | 2014-10-25 | 2015-02-04 | 胡安然 | Full-nutrition formula food for esophagus cancer |
| CN104323240A (en) * | 2014-10-21 | 2015-02-04 | 胡安然 | Full-nutrition formula food for colorectal cancer |
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2015
- 2015-04-28 CN CN201510207583.XA patent/CN104784674B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102894249A (en) * | 2012-09-06 | 2013-01-30 | 广东省农业科学院农业生物技术研究所 | Physical fatigue relieving nutrient liquid and preparation method thereof |
| CN103027926A (en) * | 2012-11-20 | 2013-04-10 | 西安泰科迈医药科技有限公司 | Pharmaceutical composition used for nutritional supplement and preparation method of oral liquid thereof |
| CN103054938A (en) * | 2013-01-31 | 2013-04-24 | 哈药集团中药二厂 | Oral preparation for conditioning stomach and intestine dysbacteriosis |
| CN104323240A (en) * | 2014-10-21 | 2015-02-04 | 胡安然 | Full-nutrition formula food for colorectal cancer |
| CN104323246A (en) * | 2014-10-25 | 2015-02-04 | 胡安然 | Full-nutrition formula food for esophagus cancer |
Non-Patent Citations (1)
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| 营养合剂治疗肠功能障碍的效果分析;谭琪 等;《中外医疗》;20131231(第15期);97,99 * |
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