CN104784674A - Nutrient solution for treating Crohn's disease and preparation method thereof - Google Patents
Nutrient solution for treating Crohn's disease and preparation method thereof Download PDFInfo
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- CN104784674A CN104784674A CN201510207583.XA CN201510207583A CN104784674A CN 104784674 A CN104784674 A CN 104784674A CN 201510207583 A CN201510207583 A CN 201510207583A CN 104784674 A CN104784674 A CN 104784674A
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Abstract
The invention discloses a nutrient solution for treating Crohn's disease and a preparation method thereof. Specifically, every 100mL of the nutrient solution comprises the following active ingredients 5-10g of codonopsis pilosula powder, 5-10g of poria cocos powder, 5-10g of whey protein hydrolysate oligopeptides, 0.3-0.8mg of vitamin A, 0.02-0.08mg of vitamin D, 1-5mg of vitamin B1, 1-5mg of vitamin B2, 1-5mg of vitamin B6, 3-10mg of iron, 3-10mg of zinc and the balance of normal saline. The nutrient solution disclosed by the invention is prepared according to the patient characteristics, is proper in ratio of various nutrients, comprehensive in nutrition, good in taste and does not have any toxic or side effect, adequate nutrition can be provided, intestinal burden is not increased, the flora and mucous membranes at different parts in the gastrointestinal tract can be adjusted and repaired, and absorption of the nutrients can be increased by improving the intestinal mucosa barrier function.
Description
Technical field
The invention belongs to clinical nutriology field, relate to a kind of nutritional solution being used for the treatment of crohn and preparation method thereof.
Background technology
Crohn (have another name called Crohn disease, English name is Crohn ' s disease, is called for short CD) is a kind of agnogenic bowl inflammatory diseases, all can occur, but be apt to occur in terminal ileum and right hemicolon at any position of gastrointestinal.Both this disease and chronic non-specific ulcerative colitis (ulceralive colitis is called for short UC) are referred to as inflammatory bowel (inflammatory bowel disease is called for short IBD).This sick clinical manifestation is stomachache, diarrhoea, intestinal obstruction, shows outward with intestinal such as heating, malnutrition.The many delays of the course of disease, recurrent exerbation, not easily effects a radical cure.This sick etiology unknown, doubtful have certain relation with infection, heredity, humoral immunization and cellular immunization.At present, this disease there is no basic cure method, and many patients develop complications, and need operative treatment, but Postoperative recurrent rate is very high.This palindromia rate and extent of disease, the factor such as power, the prolongation of the course of disease, the growth at age that disease is attacked are relevant, and mortality rate also increases thereupon.Sufferer often causes because of loss of appetite, chronic diarrhea and Chronic consumptions becoming thin, the symptom such as anemia, hypoproteinemia, vitamin deficiency, calcium deficiency, osteoporosis, is a kind of digestive tract disease without specific treatment method.
The intestinal dysfunction that crohn causes is one of modal clinical problem.At present, the most attention of clinicist has been subject to.The intestinal dysfunction of crohn patient directly has influence on the nutrition of patient, barrier, immunity, directly has influence on lapsing to of patient.When intestinal function generation obstacle, digestive and absorptive functions obviously goes down or completely loses, and this not only can cause the malnutrition of body, resistance declines, and can affect the psychology of crohn patient, makes its rehabilitation slow.As can be seen here, nutritional support is an indispensable remedy measures to the intestinal dysfunction that crohn causes.
Since the eighties in 20th century, the advantage of enteral nutrition is familiar with gradually.Research is thought, except supply nutrition, enteral nutrition also has the special role of short intestinal mucosa growth, is conducive to intestinal function recovery.But the treatment of the intestinal dysfunction caused for crohn there is no effect method so far.Once someone adopted the multiple nutrients formula easily absorbed to treat crohn, although the method partly can improve the nutriture of patient, did not fundamentally improve the function of intestinal canal of patient, and if any accidentally, also can add the intestinal burden of heavy patient.Therefore, invent a kind of nutrient formulation being suitable for treating crohn patient intestinal dysfunction and just become one of major issue of clinical nutriology needs solution.
Summary of the invention
For above-mentioned situation, the present invention aims to provide a kind of nutritional solution being used for the treatment of crohn and preparation method thereof, the crohn patient suffering from intestinal dysfunction is made to be improved trophic level and the function of intestinal canal of patient by the non-drug means such as nutritional solution and relevant nutrition guide taking particular formulation, improve patient's gut barrier function and body immunity, be conducive to lapsing to of patient, thus improve the life quality of patient, shorten the hospital stays.
In order to achieve the above object, the invention provides a kind of nutritional solution being used for the treatment of crohn, the active component comprised in nutritional solution described in every 100 mL and consumption as described below.
Radix Codonopsis powder 5 ~ 10 g;
Poria powder 5 ~ 10 g;
Lact albumin hydrolysate small peptide 5 ~ 10 g;
Vitamin A 0.3 ~ 0.8 mg;
Vitamin D 0.02 ~ 0.08 mg;
Vitamin B1 1 ~ 5 mg;
Vitamin B2 1 ~ 5 mg;
Vitamin B6 1 ~ 5 mg;
Ferrum 3 ~ 10 mg;
Zinc 3 ~ 10 mg;
Normal saline surplus.
Preferably, in technique scheme, described Radix Codonopsis powder and Poria powder are all obtained by crushing technology conventional in this area, and wherein Radix Codonopsis is the dry root of campanulaceae Codonopsis plant Radix Codonopsis, element flower Radix Codonopsis or radix codonpsis tangshen etc., and Poria is the dry sclerotia of On Polyporaceae Poria.
Preferably, in technique scheme, described lact albumin hydrolysate small peptide is the oligopeptide that lactalbumin or lactalbumin obtain after protease hydrolysis concentrates, and comprises 2 ~ 3 aminoacid.
Preferably, in technique scheme, described normal saline to be mass concentration be 0.85 ~ 0.9% sodium-chloride water solution, the preferably sodium-chloride water solution of 0.9%, namely in every 1 kg aqueous solution containing 9 g sodium chloride.
Preferably, in technique scheme, the temperature of described normal saline is 60 ~ 70 DEG C.
On the other hand, the invention provides a kind of for the preparation of the above-mentioned method being used for the treatment of the nutritional solution of crohn, it comprises the following steps:
(1) also weighed according to the consumption of the final volume calculated activity component of nutritional solution;
(2) in appropriate normal saline, add the lact albumin hydrolysate small peptide, Radix Codonopsis powder, Poria powder, vitamin B group, vitamin A, vitamin D, ferrum and the zinc that weigh in step (1) successively, limit edged stirs, and obtains mixed liquor;
(3) add normal saline to final volume in the mixed liquor obtained in step (2), after mix homogeneously, obtain the nutritional solution being used for the treatment of crohn.
Preferably, in technique scheme, described in step (2) and step (3), normal saline is the sodium-chloride water solution that mass concentration is 0.85 ~ 0.9%, the preferably sodium-chloride water solution of 0.9%, namely in every 1 kg aqueous solution containing 9 g sodium chloride.
Preferably, in technique scheme, described in step (2) and step (3), the temperature of normal saline is 60 ~ 70 DEG C.
Due to the utilization of technique scheme, the present invention compared with prior art has the following advantages:
1, in nutritional solution of the present invention, the proportioning of various nutrient is suitable, comprehensive nutrition, and mouthfeel is better simultaneously; In addition, this nutritional solution is prepared, edible safety according to patient's feature, has no side effect;
2, for intestinal dysfunction, health malnutrition and gut muco-membranous barrier dysfunction etc. that crohn causes, nutritional solution of the present invention can provide abundant nutrition, do not increase the weight of intestinal burden, can the flora of different parts in patient's gastrointestinal tract and mucosa be adjusted and be repaired again, make it closer to ecosystem, and the absorption of the element that to be had additional nutrients by gut muco-membranous barrier function can be improved;
3, the non-drug means such as nutritional solution and nutrition guide by taking particular formulation of the present invention contribute to improving intestinal dysfunction and the nutriture of crohn patient, this is to the life quality improving crohn patient, alleviate patient family, society and national each side burden significant.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiments.
Embodiment 1: the preparation being used for the treatment of the nutritional solution (100 mL) of crohn.
Nutritional solution is prepared according to following formula:
Radix Codonopsis powder 10 g;
Poria powder 10 g;
Lact albumin hydrolysate small peptide 10 g;
Vitamin A 0.8 mg;
Vitamin D 0.08 mg;
Vitamin B1 5 mg;
Vitamin B2 5 mg;
Vitamin B6 5 mg;
Ferrum 10 mg;
Zinc 10 mg;
Normal saline (0.9%) adds to 100 mL.
Concrete steps:
1, also weighed according to the consumption of final volume (100 mL) the calculated activity component of nutritional solution;
2, in the normal saline (0.9%) of appropriate (60 mL), add lact albumin hydrolysate small peptide, Radix Codonopsis powder, Poria powder, vitamin B group, vitamin A, vitamin D, ferrum and zinc successively, limit edged stirs, and obtains mixed liquor;
3, add normal saline (0.9%) in the mixed liquor obtained in step 2 to 100 mL, after mix homogeneously, obtain the nutritional solution being used for the treatment of crohn.
Embodiment 2: the preparation being used for the treatment of the nutritional solution (100 mL) of crohn.
Nutritional solution is prepared according to following formula:
Radix Codonopsis powder 5 g;
Poria powder 5 g;
Lact albumin hydrolysate small peptide 5 g;
Vitamin A 0.3 mg;
Vitamin D 0.02 mg;
Vitamin B1 1 mg;
Vitamin B2 1 mg;
Vitamin B6 1 mg;
Ferrum 3 mg;
Zinc 3 mg;
Normal saline (0.85%) adds to 100 mL.
Concrete steps:
1, also weighed according to the consumption of final volume (100 mL) the calculated activity component of nutritional solution;
2, in the normal saline (0.85%) of appropriate (60 mL), add lact albumin hydrolysate small peptide, Radix Codonopsis powder, Poria powder, vitamin B group, vitamin A, vitamin D, ferrum and zinc successively, limit edged stirs, and obtains mixed liquor;
3, add normal saline (0.85%) in the mixed liquor obtained in step 2 to 100 mL, after mix homogeneously, obtain the nutritional solution being used for the treatment of crohn.
Embodiment 3: the preparation being used for the treatment of the nutritional solution (100 mL) of crohn.
Nutritional solution is prepared according to following formula:
Radix Codonopsis powder 8 g;
Poria powder 8 g;
Lact albumin hydrolysate small peptide 8 g;
Vitamin A 0.6 mg;
Vitamin D 0.05 mg;
Vitamin B1 3 mg;
Vitamin B2 3 mg;
Vitamin B6 3 mg;
Ferrum 6 mg;
Zinc 6 mg;
Normal saline (0.9%) adds to 100 mL.
Concrete steps:
1, also weighed according to the consumption of final volume (100 mL) the calculated activity component of nutritional solution;
2, in the normal saline (0.9%) of appropriate (60 mL), add lact albumin hydrolysate small peptide, Radix Codonopsis powder, Poria powder, vitamin B group, vitamin A, vitamin D, ferrum and zinc successively, limit edged stirs, and obtains mixed liquor;
3, add normal saline (0.9%) in the mixed liquor obtained in step 2 to 100 mL, after mix homogeneously, obtain the nutritional solution being used for the treatment of crohn.
Embodiment 4: the effect analysis of the intestinal dysfunction that nutritional solution treatment crohn of the present invention causes.
Experimental subject and method:
Select 15 ~ 35 years old crohn patient (crohn is rare disease, and case is less) 24 people (27.6 years old mean age), be divided into embodiment group and matched group at random, often organize 12 people.Embodiment group to take the nutritional solution 1 ~ 2 time of different ratio obtained in embodiment 1 to 3 every day, implements 6 months; Matched group is taken the nutritional solution prepared routinely and is carried out conventional nutrient guidance, and the symptom variation that observation and comparison is two groups, concrete outcome is as shown in table 1.
Table 1, the embodiment group of nutritional solution taking particular formulation compare with the therapeutic effect of matched group.
As seen from the above table, take the stomachache of the patient of the nutritional solution of particular formulation, diarrhoea and nutriture and be all significantly improved, the effective percentage of indices all reaches more than 80%.This serial application result shows, symptom and nutriture, the life quality of taking the crohn patient of this nutritional solution all have clear improvement.
Nutritional solution of the present invention has special nutritive validity to crohn patient, has the absorption improving gut muco-membranous barrier function, have additional nutrients element.Crohn patient can select the nutritional solution of various dose as the case may be, supplementing as normal diet.Patient is occurred that nutrient lacks and malnutrition gut muco-membranous barrier is handicapped and has certain preventive and therapeutic action, have no side effect, can long-term taking.
Claims (10)
1. be used for the treatment of a nutritional solution for crohn, the active component comprised in nutritional solution described in every 100mL and consumption as described below: 5 ~ 10g Radix Codonopsis powder; 5 ~ 10g Poria powder; 5 ~ 10g lact albumin hydrolysate small peptide; 0.3 ~ 0.8mg vitamin A; 0.02 ~ 0.08mg vitamin D; 1 ~ 5mg vitamin B1; 1 ~ 5mg vitamin B2; 1 ~ 5mg vitamin B6; 3 ~ 10mg ferrum; 3 ~ 10mg zinc; Surplus is normal saline.
2. the nutritional solution being used for the treatment of crohn according to claim 1, is characterized in that, described Radix Codonopsis powder and Poria powder are all obtained by conventional crushing technology.
3. the nutritional solution being used for the treatment of crohn according to claim 2, is characterized in that, described Radix Codonopsis is the dry root of campanulaceae Codonopsis plant Radix Codonopsis, element flower Radix Codonopsis or radix codonpsis tangshen etc.
4. the nutritional solution being used for the treatment of crohn according to claim 2, is characterized in that, described Poria is the dry sclerotia of On Polyporaceae Poria.
5. the nutritional solution being used for the treatment of crohn according to claim 1, is characterized in that, described lact albumin hydrolysate small peptide is the oligopeptide that lactalbumin or lactalbumin obtain after protease hydrolysis concentrates, and comprises 2 ~ 3 aminoacid.
6. the nutritional solution being used for the treatment of crohn according to claim 1, is characterized in that, described normal saline to be mass concentration be 0.85 ~ 0.9% sodium-chloride water solution, the preferably sodium-chloride water solution of 0.9%.
7. the nutritional solution being used for the treatment of crohn according to claim 1, is characterized in that, the temperature of described normal saline is 60 ~ 70 DEG C.
8., for the preparation of the method being used for the treatment of the nutritional solution of crohn according to any one of the claims, it comprises the following steps:
1) also weighed according to the consumption of the final volume calculated activity component of nutritional solution;
2) in appropriate normal saline, add the lact albumin hydrolysate small peptide, Radix Codonopsis powder, Poria powder, vitamin B group, vitamin A, vitamin D, ferrum and the zinc that weigh in step 1) successively, limit edged stirs, and obtains mixed liquor;
3) to step 2) in add normal saline to final volume in the mixed liquor that obtains, obtain the nutritional solution being used for the treatment of crohn after mix homogeneously.
9. method according to claim 8, is characterized in that, step 2) and step 3) described in normal saline be the sodium-chloride water solution that mass concentration is 0.85 ~ 0.9%, the preferably sodium-chloride water solution of 0.9%.
10. method according to claim 8, is characterized in that, step 2) and step 3) described in the temperature of normal saline be 60 ~ 70 DEG C.
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Cited By (1)
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| CN113679038A (en) * | 2021-08-31 | 2021-11-23 | 西安交通大学医学院第一附属医院 | Total nutrient diet composition suitable for Crohn's disease and preparation method thereof |
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| CN113679038A (en) * | 2021-08-31 | 2021-11-23 | 西安交通大学医学院第一附属医院 | Total nutrient diet composition suitable for Crohn's disease and preparation method thereof |
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