CN105029391A

CN105029391A - Medical formula food for pancreatic cancer

Info

Publication number: CN105029391A
Application number: CN201510161105.XA
Authority: CN
Inventors: 陈昕; 秦孝发; 吴�灿; 胡安然; 蔡缨
Original assignee: Jing Shanmei Biotech Inc
Current assignee: Jing Shanmei Biotech Inc
Priority date: 2015-04-08
Filing date: 2015-04-08
Publication date: 2015-11-11

Abstract

The invention belongs to the technical field of affinal-drug-and-diet formulas and new-resource foods, and particularly provides a medical formula food, a special medical formula food or a non-special medical formula food for pancreatic cancer patients. The formula is designed according to the requirement in "National Food Safety Standard General Rules on Formula Food for Special Medical Use". With consideration of the body characters of the pancreatic cancer patients, various "affinal-drug-and-diet" traditional Chinese medicines are combined reasonably according to traditional Chinese medicine essential principles, and a plurality of affinal-drug-and-diet traditional Chinese medicine extract essences which are extracted through a pre-hydrolysis SBE technology, various micro-capsulated probiotics, oligopeptides extracted through bio-enzymolysis, prebiotics, amino acids, carbohydrates, grease having health-caring functions, various vitamins and minerals are all mixed together and are subjected to other processes to obtain the medical formula food. The medical formula food can be used for satisfying nutrition requirement of the pancreatic cancer patients as a single nutritional source, and has the functions of promoting digestion and fortifying stomach, fortifying spleen and excreting dampness, engendering fluid to moisten dryness, clearing heat to removing toxin, regulating qi and relieving pain and enhancing body immunity.

Description

Cancer of pancreas medical science formula food

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula with new resource food technical field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds with small peptide, prebiotics, amino acid, carbohydrate, the cancer of pancreas medical science formula food, certain medical formula food or the non-medical formula food that have the grease of health care, B B-complex, composite mineral matter to make for auxiliary material.

Background technology

Cancer of pancreas (pancreaticcarcinoma) is common pancreatic neoplasm, that a kind of grade malignancy is very high, the malignant tumor of digestive tract that Diagnosis and Treat is all very difficult, about 90% for originating from the duct adenocarcinoma of glandular tube epithelium, its M & M obviously rises in recent years, 5 years survival rate <1%, it is one of the poorest malignant tumour of prognosis, the early stage diagnosis rate of cancer of pancreas is not high, operative mortality rate is higher, and cure rate is very low, this sick incidence of disease male sex is higher than women, the ratio of men and women is 1.5 ~ 2:1, male patient is common far beyond premenopausal women, the incidence of disease and the male sex of postmenopausal women are similar, the cause of disease of cancer of pancreas is still not fully aware of, according to clinical research, roughly sort out what time below: 1, drink: not agnate drink after its cancer of pancreas incidence of disease also have difference, show with the research of Black American and white man's cancer of pancreas incidence of disease relation, compared with white man, negro male wine-head and women moderate drinker all have comparatively high rate, 2, diabetes: insulin can impel pancreatic cancer cell growth in vitro or in body, and high concentration insulin can make IGF-1R activate, produce the growth Promotive effect comprising cell cycle progression and change, 3, smoking: large quantifier elimination supports there are close ties between cancer of pancreas and smoking.First, smoking impels carcinogen tobacco specificity N-nitrite to be secreted into bile duct, and reflux enters ductus pancreaticus subsequently, secondly, tobacco specificity N-nitrite can flow into pancreas with blood to the specific effect of organ, finally, smoking increases blood lipid level, inspires cancer of pancreas, smoker may be easily carcinogenic because cell methylation level is low, the experiment of Stolzenberg etc. confirms, keep enough folic acid and pyridoxal concentration, the danger of the cancer of pancreas relevant to smoking can be reduced, 4, helicobacter pylori: according to (Hp) research display, Hp seropositivity result is had in Pancreas cancer patients, there were significant differences compared with control group, prompting Hp infects and has correlation with cancer of pancreas, 5, coffee: investigation finds, coffee can make the danger of trouble cancer of pancreas increase by 4 times, research proves, coffee can suppress DNA repair and complete pre-induction mitosis process at DNA replication dna, it is its carcinogenic main cause, also have that many factors are sick therewith certain relation in addition, as occupation, environment, geographical etc.,

Cancer of pancreas adopts the mode of parenteral nutrition (namely inputting nutritional drugs) to carry out nutritional supplementation to cancer patient clinically more, and long-term parenteral nutrition supplements and easily causes enteron aisle Villus atrophy, and accompanying infection, thus increases the weight of the harm to body; " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science; The traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet; Allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery;

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard traditional Chinese medicine food clear stipulaties: 2.1.1 medical science formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 certain medical formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition;

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively;

Though direct probiotic oral has certain effect, but due to probio cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by the key technology research to probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and inulin and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis,

Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with Pancreas cancer patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin, several mineral materials is the medical science formula food that auxiliary material is made, certain medical formula food or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by the probio of multiple raising Pancreas cancer patients immunity and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, there is the grease of health care, multivitamin, several mineral materials is auxiliary material, the Pancreas cancer patients institute essential nutrients of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the medical science formula food that the acceptable applicable Pancreas cancer patients of people is edible, certain medical formula food or non-medical formula food.

summary of the invention:

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", the constitutive character of the Pancreas cancer patients that binding immunoassay power is low, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt Chinese medical extract elite and the new resource food of one or more medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets Pancreas cancer patients, also has soothing liver-gallbladder, regulating qi-flowing for relieving pain, promoting blood circulation and removing blood stasis, softening and resolving hard mass, invigorating spleen to remove dampness, nourishing Yin and promoting production of body fluid, the medical science formula food of effect of blood-enrich and develop immunitypty, certain medical formula food or non-medical formula food (compound prescription be combined into),

1, the main component of the present invention's formula is:

Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of Pancreas cancer patients, utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and choose following several large class medicine and carry out compatibility; Wherein: the stem of noble dendrobium, reinforcing stomach reg fluid is nourishing Yin and clearing heat; Felwort, has effect of heat-clearing, purging the liver of pathogenic fire, arresting convulsion; The root of large-flowered skullcap, has heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, the effect such as antiabortive; The coptis, has heat-clearing and damp-drying drug, effect of purging intense heat and detonicating; The dried rhizome of rehmannia, has effect of clearing heat and cooling blood, beneficial Yin and promoting production of body liquid; The red sage root, has stasis-dispelling and pain-killing, activating blood to promote menstruation, the effect of the relieving restlessness that clears away heart-fire; Rheum officinale, has and attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, effect such as the stasis of blood, removing toxic substances of dispelling; Oldenlandia diffusa, primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness; Safflower, activating blood to promote menstruation, blood stasis removing analgesic; Ligusticum wallichii, has blood-activating and qi-promoting, effect of wind-expelling pain-stopping; Selfheal, has the effect of improving eyesight of relieving inflammation or internal heat; Rhizoma cyperi, regulate the flow of vital energy Xie Yu; Menstruction regulating and pain relieving; Antiabortive; Cordyceps militaris, Chinese caterpillar fungus enters lung kidney two warp, can tonifying lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, weak after being ill, chronic cough is weak, phthisical cough phlegm blood, and spontaneous sweating etc. are unique a kind of Chinese medicine that can balance simultaneously, regulate negative and positive; Cape jasmine, has effects such as protecting liver, cholagogic, step-down, calmness, hemostasis, detumescence; Dandelion, clearing heat and detoxicating, diuresis dissipating bind; Cordate houttuynia, sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting are treated in clearing heat and detoxicating, detumescence; Purslane, clearing heat and detoxicating, loose blood detumescence; Coix seed, invigorating the spleen, tonifying lung, heat-clearing, dampness removing; Peach kernel, the broken blood stasis of blood, moisturizes laxation; Radix Glycyrrhizae, raw with cooler, can purging intense heat and detonicating, relieving spasm to stop pain; Process with partially warm, can fall apart exterior cold, tonifying middle-Jiao and Qi;

Medicinal and edible Chinese medicine extract of the present invention refers to Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall), glossy ganoderma, felwort, the root of large-flowered skullcap, the coptis, the dried rhizome of rehmannia, the red sage root, rheum officinale, oldenlandia diffusa, safflower, Ligusticum wallichii, selfheal, rhizoma cyperi, Cordyceps militaris, cape jasmine, dandelion, cordate houttuynia, purslane, coix seed, peach kernel, Radix Glycyrrhizae, , fructus amomi, oyster, marine alga, red date, mulberry leaf, chrysanthemum, cassia seed, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, Qingqian Willow leaf, tealeaves theanine, Tea Flower, Guangdong Cordyceps militaris, yeast beta-dextran, Saussurea involucrata culture, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa one wherein, several or whole, biological enzymolysis or prehydrolysis SBE is adopted to extract and microencapsulation, mixture after spray-dried and cryodesiccated extract,

2, multiple probio: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, builds up resistance;

Multiple probio of the present invention all adopts the probio after microencapsulation, and the probio described in it is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici are wherein a kind of, several or all mix;

Bifidobacterium above a refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above b refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri;

3, small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix;

4, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, stimulate enterocinesia to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of enhancing cancer of pancreas resistance;

Prebiotics of the present invention is 2 classes

A. have very strong field planting effect prebiotics to external source probio: Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin extract;

B. common prebiotics: oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide, cotton seed compound sugar, trehalose, stachyose, yeast;

Prebiotics of the present invention is: the extract of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, trehalose, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;

5, carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, trehalose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix;

6. there is the grease of health care to refer to there is health-care effect to the person, and finished product energy can be increased, make the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal); As the street cleaner that fish oil is human vas, can also prevention of arterial sclerosis, apoplexy and heart disease.Fish oil is the diseases such as hypertension, coronary heart disease, headstroke, diabetes, rheumatic arthritis, cancer; Linseed oil has fat-reducing, reduces cholesterol, improves the effects such as renal function; Peony seed oil has reducing blood lipid and hypotensive, strengthens autoimmunity, prevention diabetes, effect of anti-curing cancers; Samara oil prevents and treats hypertension, high fat of blood, effect of the illnesss such as vascular sclerosis;

Of the present invention have the grease of health care to refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix,

7. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix;

8. vitamin and mineral matter: vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat cancer of pancreas significantly improves compared with the like product of market;

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

The characteristic of this formula medical science formula food and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of Pancreas cancer patients, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility;

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is adopted to be primary raw material, with prebiotics, carbohydrate, the grease having health care, amino acid, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect;

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb fast, completely, Pancreas cancer patients desired nutritional can be supplemented rapidly;

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, there is the effect strengthening resistance of human body, also have soothing liver-gallbladder, regulating qi-flowing for relieving pain, promoting blood circulation and removing blood stasis, effect of softening and resolving hard mass, invigorating spleen to remove dampness, nourishing Yin and promoting production of body fluid, blood-enrich and develop immunitypty;

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced,

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve Pancreas cancer patients negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa;

7. this prescription have employed this team by the achievement to probio key technology research of field planting mechanism in enteron aisle over nearly 3 year, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio;

8. prebiotics contained in the present invention's formula, by promoting the growth and breeding of probio in intestines, suppress the growth of spoilage organisms, form one protective barrier at intestinal mucosal surface simultaneously, the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted, reduce the absorption of intestinal toxic material, intestines peristalsis can also be promoted, accelerate the discharge of residuals in intestines, constipation can be prevented, and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy;

9, in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

10. in the present invention's formula, the contained grease of health care that has not only has health-care effect to the person, and provides the energy needed for normal life for human body, makes the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal);

11, contained in the present invention's formula amino acid, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development;

12, formula food of the present invention is containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for Pancreas cancer patients, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element;

13, not fatty and cholesterol in the present invention's formula, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following case study on implementation, the invention will be further described, and it will contribute to understanding the present invention.

Case study on implementation one

Realizing the object of the invention cancer of pancreas medical science formula food is constitutive character in conjunction with Pancreas cancer patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease multivitamin of health care, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: Cordyceps sinensis (aweto mycelium) 12g, stem of noble dendrobium 12g, lucidum spore powder (broken wall) 11g, glossy ganoderma 11g, felwort 10g, root of large-flowered skullcap 10g, coptis 9g, dried rhizome of rehmannia 9g, red sage root 9g, rheum officinale 8g, oldenlandia diffusa 8g, safflower 8g, Ligusticum wallichii 8g, selfheal 7g, rhizoma cyperi 7g, Cordyceps militaris 7g, cape jasmine 6g, dandelion 6g, cordate houttuynia 6g, purslane 6g, coix seed 6g, peach kernel 6g, Radix Glycyrrhizae 6g, fructus amomi 5g, oyster 5g, marine alga 5g, red date 5g, mulberry leaf 5g, chrysanthemum 5g, cassia seed 5g, line leaf broom top 5g, eucommia Bark male flower 4g, Euglena 4g, phoenix peony 4g, combined spicebush leaf 4g, leaf of Moringa 3g, Noni fruit 3g, Acerola cherry fruit 3g, Opuntia ficus 3g, Leaves of Hippophae L 3g, it shellfish 2g, cynanchum auriculatum Royle 2g, Qingqian Willow leaf 2g, tealeaves theanine 1g, Tea Flower 1g, the sub-1g of Guangdong Cordyceps militaris, yeast beta-dextran 5g, Saussurea involucrata culture 3g, currant lobate layer bacterium fermentation mycelium 2g, chlorella pyrenoidosa 1g,

Multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

First will to be glossy ganoderma during making, felwort, the root of large-flowered skullcap, the coptis, the dried rhizome of rehmannia, the red sage root, rheum officinale, oldenlandia diffusa, safflower, Ligusticum wallichii, selfheal, rhizoma cyperi, cape jasmine, dandelion, cordate houttuynia, purslane, coix seed, peach kernel, Radix Glycyrrhizae, , fructus amomi, oyster, marine alga, red date, mulberry leaf, chrysanthemum, cassia seed, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, Qingqian Willow leaf, Tea Flower soak after add cycloheptaamylose, with prehydrolysis SBE technology extract after, spray-dried and preparation flour, then add biological enzymolysis extract Cordyceps sinensis (aweto mycelium), Guangdong Cordyceps militaris, the stem of noble dendrobium, lucidum spore powder (broken wall), Cordyceps militaris, yeast beta-dextran, Saussurea involucrata culture, tealeaves theanine, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa, small peptide, prebiotics, amino acid, carbohydrate, there is the grease of health care, carry out pasteurization after multivitamin and mineral matter are pulverized and mixed together 1 hour, then add the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus also mixes the solid beverage making powdery, granule, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations is all meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require,

Manufacture craft of the present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat cancer of pancreas significantly improves compared with the like product of market.

Case study on implementation two

Above-mentioned cancer of pancreas medical science formula food also comprises following component by weight, the extract of medicine-food two-purpose: Cordyceps militaris 7g, cape jasmine 6g, dandelion 6g, cordate houttuynia 6g, purslane 6g, coix seed 6g, peach kernel 6g, Radix Glycyrrhizae 6g, fructus amomi 5g, oyster 5g, marine alga 5g, red date 5g, mulberry leaf 5g, chrysanthemum 5g, cassia seed 5g, line leaf broom top 5g, eucommia Bark male flower 4g, Euglena 4g, phoenix peony 4g, combined spicebush leaf 4g, leaf of Moringa 3g, Noni fruit 3g, Acerola cherry fruit 3g, Opuntia ficus 3g, Leaves of Hippophae L 3g, it shellfish 2g, cynanchum auriculatum Royle 2g, Qingqian Willow leaf 2g, tealeaves theanine 1g, Tea Flower 1g, the sub-1g of Guangdong Cordyceps militaris, yeast beta-dextran 5g, Saussurea involucrata culture 3g, currant lobate layer bacterium fermentation mycelium 2g, chlorella pyrenoidosa 1g, prebiotics 350g, probio 300g, small peptide 150g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, water-soluble dietary fiber 50g, vitamin and mineral matter 25g.

Case study on implementation three

Above-mentioned cancer of pancreas medical science formula food also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation four

The certain medical formula food of above-mentioned cancer of pancreas also comprises following component by weight: prebiotics 700g, small peptide 500g, carbohydrate 300g, multiple probio 300g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation five

Above-mentioned cancer of pancreas medical science formula food also comprises following component by weight: prebiotics 500g, small peptide 350g, carbohydrate 300g, multiple probio 250g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation six

Above-mentioned cancer of pancreas medical science formula food also comprises following component by weight: small peptide 350g, prebiotics 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Claims

1. cancer of pancreas medical science formula food, it is characterized in that the constitutive character in conjunction with Pancreas cancer patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease of health care, multivitamin, several mineral materials to make for auxiliary material;

First will to be glossy ganoderma during making, felwort, the root of large-flowered skullcap, the coptis, the dried rhizome of rehmannia, the red sage root, rheum officinale, oldenlandia diffusa, safflower, Ligusticum wallichii, selfheal, rhizoma cyperi, cape jasmine, dandelion, cordate houttuynia, purslane, coix seed, peach kernel, Radix Glycyrrhizae, , fructus amomi, oyster, marine alga, red date, mulberry leaf, chrysanthemum, cassia seed, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, Qingqian Willow leaf, Tea Flower soak after add cycloheptaamylose, with prehydrolysis SBE technology extract after, spray-dried and preparation flour, then add biological enzymolysis extract Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, Guangdong Cordyceps militaris, lucidum spore powder (broken wall), Cordyceps militaris, yeast beta-dextran, Saussurea involucrata culture, tealeaves theanine, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa, small peptide, prebiotics, amino acid, carbohydrate, there is the grease of health care, carry out pasteurization after multivitamin and mineral matter are pulverized and mixed together 1 hour, then add the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus also mixes the solid beverage making powdery, granule, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations is all meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require,

Manufacture craft of the present invention is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat cancer of pancreas significantly improves compared with the like product of market.

2. cancer of pancreas medical science formula food according to claim 1, it is characterized in that described medicine-food two-purpose Chinese herbal medicine extract and new resource food are: glossy ganoderma, felwort, the root of large-flowered skullcap, the coptis, the dried rhizome of rehmannia, the red sage root, rheum officinale, oldenlandia diffusa, safflower, Ligusticum wallichii, selfheal, rhizoma cyperi, cape jasmine, dandelion, cordate houttuynia, purslane, coix seed, peach kernel, Radix Glycyrrhizae, , fructus amomi, oyster, marine alga, red date, mulberry leaf, chrysanthemum, cassia seed, line leaf broom top, eucommia Bark male flower, Euglena, phoenix peony, combined spicebush leaf, leaf of Moringa, Noni fruit, Acerola cherry fruit, Opuntia ficus, Leaves of Hippophae L, it shellfish, cynanchum auriculatum Royle, Qingqian Willow leaf, tealeaves theanine, Tea Flower, Guangdong Cordyceps militaris, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall), Cordyceps militaris, yeast beta-dextran, Saussurea involucrata culture, currant lobate layer bacterium fermentation mycelium, chlorella pyrenoidosa one wherein, several or all mix.

3. cancer of pancreas medical science formula food according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. cancer of pancreas medical science formula food according to claim 1, also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

5. cancer of pancreas medical science formula food according to claim 1, is characterized in that described probio is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici, wherein a kind of, several or all mix;

Bifidobacterium above refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri.

6. cancer of pancreas medical science formula food according to claim 1, it is characterized in that described prebiotics is: the extraction mixture of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, trehalose, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix.

7. cancer of pancreas medical science formula food according to claim 1, is characterized in that described amino acid is: Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

8. the medical science formula food of cancer of pancreas according to claim 1, is characterized in that described carbohydrate is that carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, trehalose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

9. cancer of pancreas medical science formula food according to claim 1, it is characterized in that the described grease of health care that has is: refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix.

10. cancer of pancreas medical science formula food according to claim 1, is characterized in that described small peptide is: marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.