CN109498709A - A kind of Chinese medicine composition and preparation method thereof for treating mastitis for milk cows - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating mastitis for milk cows Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention provides a kind of Chinese medicine composition and preparation method thereof for treating mastitis for milk cows, and the Chinese medicine composition includes the raw material components of following parts by weight: 3-9 parts of honeysuckle, 3-9 parts of Radix Angelicae Sinensis, 2-6 parts of radix paeoniae rubra, 2-6 parts of dandelion, 2-6 parts of folium isatidis, 2-6 parts of the seed of cowherb, 2-6 parts of olibanum, 2-6 parts of Radix Astragali, 1-3 parts of green peel and 1-3 parts of Radix Glycyrrhizae.It not only include a variety of small active peptides, chelating peptide in the Chinese medicine composition for the treatment of mastitis for milk cows provided by the invention, it further include a variety of Chinese herbal medicine active components, multivitamin and microelement, mastitis for milk cows can efficiently be treated, after the additive, it can reduce or without using antibiotic and other medicines additive, overcome antibiotic and chemical synthesis additive to have the defects that residual and side effect, is suitable for being promoted in husbandry sector, has broad application prospects.
Description
Technical field
The present invention relates to veterinary Chinese medicine technical field more particularly to a kind of Chinese medicine composition for treating mastitis for milk cows and its
Preparation method.
Background technique
Mastitis for milk cows is milk cow one of the most common type mammary gland disease, refers to cow mammary gland by virus, bacterium intrusion institute
The variation of caused inflammatory, initial stage or milk production higher period when being common in high yield cow lactation are the common diseases, multiple of milk cow
Disease.Mastitis for milk cows not only declines the output of milk of milk cow, but also reduces the quality of milk, shortens the service life of milk cow, increases
Add the cost of standby milk cow, increases the service fee of additional labor expense, drug spending and animal doctor, extend post-partum estrus and gestation
Time causes huge economic loss to dairy.
Method in relation to preventing and treating mastitis for milk cows is mainly that antibiotherapy and chemical synthetic drug are treated.For a long time,
Antibiotic and chemical synthetic drug are largely used, milk cow is will lead to and drug resistance occurs, also will cause in cow's milk has a large amount of resist
Raw element residual, this dairy products, which are eaten for a long time, to be detrimental to health.Therefore, how to solve medicament residue problem and drug resistance is asked
Topic becomes the hot spot of current people research.Chinese medicine derives from animal, plant or minerals, is not easy that pathogenic bacteria is made to generate drug resistance,
Metabolism is very fast in vivo, high-efficiency low-toxicity noresidue, does not influence the edible of milk during treatment, has drug and the dual function of nutritional agents concurrently
Effect, both can restraining and sterilizing bacteria, enhancing animal body immune function but also as Specialty bio active additive adjust the new of body
Old metabolism promotes the absorption of nutriment.But the existing Chinese materia medica preparation for treating mastitis for milk cows often exists at present
The problems such as additive amount is bigger than normal, and using effect is unstable becomes the bottleneck for restricting its industrialization.
Summary of the invention
Often have that additive amount is bigger than normal, and using effect is unstable for the existing Chinese materia medica preparation for treating mastitis for milk cows
Fixed problem, the present invention provide a kind of Chinese medicine composition and preparation method thereof for treating mastitis for milk cows.
In order to solve the above technical problems, present invention provide the technical scheme that
A kind of Chinese medicine composition for treating mastitis for milk cows, the raw material components including following parts by weight: honeysuckle 3-9
Part, 3-9 parts of Radix Angelicae Sinensis, 2-6 parts of radix paeoniae rubra, 2-6 parts of dandelion, 2-6 parts of folium isatidis, 2-6 parts of the seed of cowherb, 2-6 parts of olibanum, Radix Astragali 2-
6 parts, 1-3 parts and Radix Glycyrrhizae 1-3 parts of green peel.
Compared with the existing technology, the Chinese medicine composition for the treatment of mastitis for milk cows provided by the invention, it then follows monarch
Principle has determined that above-mentioned ten tastes medicinal material carries out compatibility, wherein it is synergistic between various traditional Chinese medicine ingredients, it mutually promotes, has prescription
There is clearing heat and detoxicating a, antibacterial anti-inflammatory, it is active to promote lactation and other effects, achieve the effect that good treatment mastitis for milk cows；Wherein, smalt
Leaf and dandelion collaboration can enhance the antibacterial action of honeysuckle；Radix Astragali, Radix Angelicae Sinensis collaboration can reach it is qi-blood tonifying, righting of getting rid of evils, mention
The effect of high immunity of organisms；Olibanum, the seed of cowherb and dandelion collaboration can slow down the sense of discomfort of milk cow, are conducive to lactation and repair
Multiple damaged tissues；Green peel compatibility Radix Glycyrrhizae, can reconcile the tonifying Qi and bloods drug such as Radix Astragali, Radix Angelicae Sinensis taste it is greasy, assist other medicinal materials to play
Normal effect.Chinese medicine composition provided by the invention fundamentally can treat and prevent and treat milk cow under each component synergistic effect
Mammitis, cure rate can reach 94% or more, and not will cause medicament residue, caused by avoiding because antibiotic is used for a long time
The generation of cow's milk drug residue and bacterial drug resistance problem.
Preferably, the Chinese medicine composition of the treatment mastitis for milk cows includes the raw material components of following parts by weight: gold and silver
4-8 parts of flower, 5-7 parts of Radix Angelicae Sinensis, 3-5 parts of radix paeoniae rubra, 3-5 parts of dandelion, 3-5 parts of folium isatidis, 3-5 parts of the seed of cowherb, 3-5 parts of olibanum,
3-5 parts of Radix Astragali, 1.5-2.5 parts and Radix Glycyrrhizae 1.5-2.5 parts of green peel.
It is furthermore preferred that the Chinese medicine composition of the treatment mastitis for milk cows includes the raw material components of following parts by weight: gold
6 parts of honeysuckle flower, 6 parts of Radix Angelicae Sinensis, 4 parts of radix paeoniae rubra, 4 parts of dandelion, 4 parts of folium isatidis, 4 parts of the seed of cowherb, 4 parts of olibanum, 4 parts of Radix Astragali, green peel 2
Part and 2 parts of Radix Glycyrrhizae.
In compatibility of the present invention:
Honeysuckle, it is cold in nature, sweet in flavor, enter lung, stomach, the heart, spleen four pass through, modern pharmacological studies have shown that its with antibacterial, it is antiviral,
Inhibit ulcer and enhance the effect of immune function, inhibits and kill to make well experiments have shown that honeysuckle has various pathogens
With can reinforce immunity of organisms, have a special efficacy to mastitis for milk cows, chlorogenic acid contained in honeysuckle has antibacterial, disease-resistant
The effects of poison, hemostasis, while also having the function of strengthen immunity, body can be induced to generate interferon, improve the machine of milk cow
Body function alleviates the state of an illness；Furthermore chlorogenic acid contained in honeysuckle also has clearing heat and detoxicating effect, and disease can be effectively relieved
Shape.
Radix Angelicae Sinensis, sweet in flavor and weigh, it can enrich blood and invigorate blood circulation, not only can promoting menstruation, but also can be active, Radix Angelicae Sinensis, radix paeoniae rubra in the present invention
It is synergistic with Radix Astragali three, the effect of not only can reach tonifying Qi and blood, improve immunity, it can also improve the microcirculation of milk cow,
Enhance mammary glandular cell to the repair ability of damage.
Radix paeoniae rubra, bitter, slightly cold, return liver warp has the effect of clearing heat and cooling blood, promoting blood circulation, is clinically used for febrile virulent maculae, and hot eyes is swollen
Bitterly, too fat to move sore, the symptoms such as liver-depressed hypochondrium pain, result of study show contraction of the red paeonia extract to the arteriole of burned rats
There is apparent antagonism, has certain stabilization to burned rats mesenterium arteriole blood flow velocity, moreover it is possible to mitigate micro-
The aggregation of red blood cell in recycling.
Dandelion, it is bitter, sweet, have the function of clearing heat and detoxicating, dispersing swelling and dissipating binds and inducing diuresis for treating strangurtia, be usually used in treating pyogenic infections from tumour or sore,
The symptoms such as acute mastitis, remorse tired, puckery pain of heat gonorrhea, in addition to significant antibacterial and anti-inflammation functions, the effect that also promotes lactation.
Folium isatidis, active constituent are mainly indigo red, have effects that clearing heat and detoxicating, cooling blood and hemostasis, extract is to dysentery
A variety of pathogenic microorganisms such as Shigella, meningococcus, conveyor screw have inhibition and killing effect.Folium isatidis and Pu in the present invention
Public English collaboration can enhance the antibacterial action of honeysuckle.
The seed of cowherb, it is bitter in taste flat, return liver, stomach meridian, contain triterpenoid saponin, glycosides displayed also contains phytin, phosphatide, beans steroid
Alcohol etc. has the effect of blood circulation, lower cream detumescence, inducing diuresis for treating strangurtia.
Olibanum, property is arduous, warm, enters the heart, liver, the spleen channel, has the effect of promoting blood circulation, promoting the circulation of qi, analgesic.Olibanum can mention in the present invention
The antibacterial effect of high dandelion acts synergistically with the seed of cowherb and dandelion, can be relieved the discomfort of milk cow during one's sickness, be conducive to
Lactation and reparation damaged tissues, reduce the appearance that the output of milk as caused by illness is remarkably decreased problem to the greatest extent.
Radix Astragali, Gan Wen enter the spleen channel, are the key medicine of invigoration spleen qi, can promote the synthesis of protein, for sore invagination, purulence
At not bursting or burst for a long time and does not holds back person, there is the effect of good promoting pus discharge and tissue regeneration, also contain in Radix Astragali there are many antibiotic effective ingredient, can increase
The immune function of strong body.
Green peel, property is arduous, temperature, can invigorating the spleen promoting the circulation of qi, have effects that soothing the liver relieving stagnant Qi, disperse accumulationization be stagnant, promoting qi circulation and relieving pain, can enhance
The digestion power of milk cow during one's sickness, enhances the appetite of milk cow, avoids the milk production as caused by loss of appetite and indigestion
The decline of amount decline and Abwehrkraft des Koepers.Green peel compatibility Radix Glycyrrhizae in the present invention, the easy qi and blood drug of the benefits such as Radix Astragali, Radix Angelicae Sinensis that can reconcile
It grows greasy, assists its effect of bringing into normal play.
Radix Glycyrrhizae, it is sweet in flavor, mild-natured, have replenish qi to invigorate the spleen, moistening lung to arrest cough, relieving spasm to stop pain, clearing heat and detoxicating effect, in the present invention
In have the function of coordinating the drug actions of a prescription, alleviate the toxicity and strong effect of drug.
Chinese veterinarian's traditional theory thinks that mammitis, that is, acute mastitis is that phlegm, wet, gas, blood stasis knot do not dissipate and be inflammation.Therefore, this hair
It is bright with clearing heat and detoxicating, dredging collateral and promoting blood circulation, swelling and pain relieving, it is active promote lactation as principle of reatment, select clearing heat and detoxicating, promoting blood circulation, inducing diaphoresis
The drug of dampness removing is aided with the medicine of help, qi-regulating, with tonifying Qi and lifting yang, righting of getting rid of evils, to reach the mesh for the treatment of mastitis for milk cows
's.
The present invention also provides a kind of preparation methods of Chinese medicine composition for treating mastitis for milk cows, comprising the following steps:
Step 1: according to design proportion weigh honeysuckle, Radix Angelicae Sinensis, radix paeoniae rubra, dandelion, folium isatidis, the seed of cowherb, olibanum,
Radix Astragali, green peel and Radix Glycyrrhizae are added 7-8 times of purified water of raw material weight, stir evenly, and in 90-95 DEG C of decoction 7-8h, must decoct
Mixture；
Step 2: the decoction mixture is cooled to 56-58 DEG C, amylase, neutral proteinase and cellulase is added,
Stirring enzymatic hydrolysis 3-4h, obtains enzymolysis liquid；
Step 3: the enzymolysis liquid heat temperature raising is carried out enzyme-deactivating, isolate and purify, is concentrated, it is dry, milk cow's milk must be treated
The Chinese medicine composition of room inflammation.
Not only small point rich in the Chinese medicine composition for treating mastitis for milk cows prepared by above-mentioned preparation method
Sub- active peptide, and be more fully extracted the chlorogenic acid contained in Chinese medicine preparation raw material, ligusticum sinense oliver lactones, Paeoniflorin, caffeic acid,
The active ingredient of Chinese herbs such as indigo red, vacsedoside, masticinic acid, Astragaloside IV, Radix Astragali oligosaccharide, glycosides displayed and liquiritin with
And the multivitamins such as the multi minerals such as Ca, Fe, Zn, Se prime element and vitamin C, vitamin E, moreover, by amylase, neutrality
The small-molecular peptides that protease and cellulase complex enzyme hydrolysis obtain also have very high sequestering activity, can with the oligosaccharide of extraction and
Multi mineral prime element is chelated, and a variety of chelates are obtained, and is more advantageous to the digestion and absorption of mineral matter element and oligosaccharide.
Keratin is that lactating cow prevents from defending for first of intramammary infection, and there are about 50% angle eggs during secretion lotion
It is white to be discharged and loss with milk, it need to be supplemented rapidly when keratin loss, latex dust otherwise can be caused to have a superficial wound, simultaneously
It can also cause bacterium infection that mastitis for milk cows disease incidence is then caused to improve.The small molecule short peptide chelate that the present invention is prepared
The absorption rate of amino acid in vivo can be improved, reduce the antagonism between amino acid, promote the synthesis of protein, mend rapidly
Fill the keratin of loss；The antagonism between the mineral matter elements such as Ca, Zn, Se, Fe or other microelements can be also reduced,
So that the active constituent in formula is preferably absorbed, improve the bioavilability of Chinese medicine, to improve to mastitis for milk cows
Cure rate.
Small molecular small peptide chelated zinc of the present invention can promote the synthesis of keratin, cooperate with other small molecule small peptides and minerals
Element and vitamin E can supplement rapidly the keratin of loss, and prevention and treatment mammitis is further aggravated, and accelerate mammitis and cure speed
Degree；Small molecule small peptide chelating selenium is remarkably improved the output of milk of milk cow, makes milk cow after mammitis healing, can secrete quick-recovery fastly
Cream makes milk cow repair and form benign cycle in production process.
The purity is high of the Chinese medicine composition product of the treatment mastitis for milk cows of the method for the present invention preparation, product middle-molecular-weihydroxyethyl exist
1000 dalton small-molecular peptides content below reaches 96% or more, is conducive to animal and quickly absorbs；Molecular weight is the road 180-500
The small-molecular peptides content that you pause can reach 50% or so, and bioactivity is high；Therefore, the usage amount that can reduce Chinese medicine composition, is controlled
The 1/30-1/50 that usage amount only has conventional Chinese medicine usage amount is treated, treatment cost is reduced.
For Chinese medicine composition provided by the invention when treating mastitis for milk cows, every ox day usage amount is 5-10g, is continuously made
With 3-5 days.
Preferably, in step 2, the additional amount of the amylase is the 1-1.5% of raw material weight, the neutral proteinase
Additional amount be raw material weight 1-1.5%, the additional amount of the cellulase is the 0.8-1.2% of raw material weight.
The additional amount of preferred amylase, neutral proteinase and cellulase, can be improved the conversion that albumen is converted into polypeptide
Rate, improves the recovery rate of small-molecular peptides, while also can be shortened enzymolysis time, improves production efficiency.
Preferably, the amylase is aspergillus niger amylase.
Preferably, the neutral proteinase is aspergillus oryzae neutral proteinase.
Preferably, the cellulase is Li Shi trichoderma cellulase.
Aspergillus niger amylase is excision enzyme, and aspergillus oryzae neutral proteinase is restriction endonuclease, and Li Shi trichoderma cellulase is inscribe
The complex enzyme of enzyme and excision enzyme digests above-mentioned Ten Herbs using preferred complex enzyme, can more sufficiently extract each taste medicine
The active constituent and nutriment of material, while the small-molecular peptides of molecular weight Relatively centralized can also be obtained, relative molecular mass exists
1000 dalton small-molecular peptides below accounting in the polypeptide of extraction reaches 96% or more, molecular weight 180-500 dalton
Peptide accounting in the polypeptide of extraction reaches 50% or so；Meanwhile the also cleavable polypeptide for providing high sequestering activity, so that small point
The microelements highly effective chelating such as sub- polypeptide and oligosaccharide, selenium, iron, zinc, is conducive to animal and quickly absorbs, and improves the biology benefit of Chinese medicine
Expenditure.
Optionally, in step 2, mixing speed 65-70r/min.
Preferred mixing speed can be such that amylase, neutral proteinase and cellulase sufficiently contacts with raw material, improve enzyme
Solve rate.
Optionally, in step 3, the enzymolysis liquid is heated to 90-95 DEG C, 10-15 minutes progress enzymes of heat preservation go out
It is living.
Preferably, the step of being isolated and purified in step 3 specifically: by the enzymolysis liquid after inactivation successively through decanter centrifuge
It is centrifuged with three-phase centrifuge.
Decanter centrifuge is suitble to the filtering of thick liquid, more efficient than flame filter press, preliminary by decanter centrifuge
It is filtered to remove insoluble matter, grease and other suspended matters in enzymolysis liquid are then removed by three-phase centrifuge, filtering can be improved
Efficiency improves the purity of small-molecular peptides.
Optionally, the drying mode is spray drying.
Optionally, the revolving speed of the decanter centrifuge is 3500-4000r/min.
Optionally, the revolving speed of the three-phase centrifuge is 15000-20000r/min.
Preferred revolving speed can be such that the grease of enzymolysis liquid and other suspended matters preferably separates with small-molecular peptides, when shortening centrifugation
Between.
The present invention also provides a kind of drug for treating mastitis for milk cows, the Chinese medicine including above-mentioned treatment mastitis for milk cows
Composition.
Preferably, the dosage form of the drug of the treatment mastitis for milk cows is powder, granule and agent, injection, pill or cream
Agent.
Pharmaceutically acceptable auxiliary material can be added in the composition for the treatment of mastitis for milk cows provided by the invention, according to common process
Required dosage form is made, meets various use demands.
Active component in 10 kinds of bulk pharmaceutical chemicals for the treatment of mastitis for milk cows provided by the invention cooperates with and combines peptide chelate complex,
Special efficacy with treatment mammitis, and milk cow will not develop drug resistance, after the drug, can reduce or without using antibiotic or
Other medicines additive overcomes antibiotic and chemical synthesis additive to have the defects that residual and side effect, has wide answer
Use prospect.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1
The present embodiment provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 6 parts, 6 parts of Radix Angelicae Sinensis, 4 parts of radix paeoniae rubra, 4 parts of dandelion, 4 parts of folium isatidis, 4 parts of the seed of cowherb, 4 parts of olibanum, 4 parts of Radix Astragali, 2 parts of green peel
With 2 parts of Radix Glycyrrhizae.
The preparation method of the powder of above-mentioned treatment mastitis for milk cows includes the following steps:
Step 1: weigh honeysuckle 6Kg, Radix Angelicae Sinensis 6Kg, radix paeoniae rubra 4Kg, dandelion 4Kg, folium isatidis 4Kg, seed of cowherb 4Kg,
Olibanum 4Kg, Radix Astragali 4Kg, green peel 2Kg and Radix Glycyrrhizae 2Kg are added in 300L purified water, stir evenly, and under the conditions of 92 DEG C, decoct
7.5h obtains decoction mixture；
Step 2: the decoction mixture is cooled to 57 DEG C, be added the amylase of 500g, 500g neutral proteinase and
400g cellulase, stirring enzymatic hydrolysis 3.5h, enzymolysis process remain that agitator speed is 68 revs/min, obtain enzymolysis liquid；
Step 3: the enzymolysis liquid is warming up to 92 DEG C, enzyme deactivation 12 minutes；It is filtered off and is dezymotized with sleeping gong centrifuge after enzyme deactivation
Residue is solved, the revolving speed of decanter centrifuge is 3600r/min；Three-phase centrifuge Purification by filtration is used again, and the revolving speed of three-phase centrifuge is
18000r/min obtains centrifugate；The centrifugate is further concentrated through dual-effect concentrator；After concentrate spray drying, it must control
Treat the powder of mastitis for milk cows.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 7.5 grams of usage amount of ox day is used continuously 4 days.
Relative molecular mass contains in 1000 dalton small-molecular peptides below in the product of the treatment mastitis for milk cows of preparation
Amount is 98.3%, and molecular weight is that the small-molecular peptides content of 180-500 dalton can reach 52.8%.
Embodiment 2
The present embodiment provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 3 parts, 5 parts of Radix Angelicae Sinensis, 6 parts of radix paeoniae rubra, 2 parts of dandelion, 3 parts of folium isatidis, 2 parts of the seed of cowherb, 5 parts of olibanum, 2 parts of Radix Astragali, green peel 2.5
Part and 3 parts of Radix Glycyrrhizae.
The preparation method of the powder of above-mentioned treatment mastitis for milk cows includes the following steps:
Step 1: weighing honeysuckle 300g, Radix Angelicae Sinensis 500g, radix paeoniae rubra 600g, dandelion 200g, folium isatidis 300g, Wang Buliu
Row 200g, olibanum 500g, Radix Astragali 200g, green peel 250g and Radix Glycyrrhizae 300g are added in 23.5L purified water, stir evenly, at 90 DEG C
Under the conditions of, 8h is decocted, decoction mixture is obtained；
Step 2: the decoction mixture is cooled to 56 DEG C, be added the amylase of 33.5g, 33.5g neutral proteinase and
26.8g cellulase, stirring enzymatic hydrolysis 3h, enzymolysis process remain that agitator speed is 65 revs/min, obtain enzymolysis liquid；
Step 3: the enzymolysis liquid is warming up to 90 DEG C, enzyme deactivation 15 minutes；It is filtered off and is dezymotized with sleeping gong centrifuge after enzyme deactivation
Residue is solved, the revolving speed of decanter centrifuge is 3500r/min；Three-phase centrifuge Purification by filtration is used again, and the revolving speed of three-phase centrifuge is
15000r/min obtains centrifugate；The centrifugate is further concentrated through dual-effect concentrator；After concentrate spray drying, it must control
Treat the powder of mastitis for milk cows.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 5 grams of usage amount of ox day is used continuously 5 days.
Relative molecular mass contains in 1000 dalton small-molecular peptides below in the product of the treatment mastitis for milk cows of preparation
Amount is 96.7%, and molecular weight is that the small-molecular peptides content of 180-500 dalton can reach 51.2%.
Embodiment 3
The present embodiment provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 4 parts, 7 parts of Radix Angelicae Sinensis, 3 parts of radix paeoniae rubra, 6 parts of dandelion, 6 parts of folium isatidis, 3 parts of the seed of cowherb, 2 parts of olibanum, 3 parts of Radix Astragali, 1 part of green peel
With 1.5 parts of Radix Glycyrrhizae.
The preparation method of the powder of above-mentioned treatment mastitis for milk cows includes the following steps:
Step 1: weighing honeysuckle 400g, Radix Angelicae Sinensis 700g, radix paeoniae rubra 300g, dandelion 600g, folium isatidis 600g, Wang Buliu
Row 300g, olibanum 200g, Radix Astragali 300g, green peel 100g and Radix Glycyrrhizae 150g are added in 29.2L purified water, stir evenly, at 95 DEG C
Under the conditions of, 7h is decocted, decoction mixture is obtained；
Step 2: the decoction mixture is cooled to 58 DEG C, be added the amylase of 54.8g, 54.8g neutral proteinase and
43.8g cellulase, stirring enzymatic hydrolysis 4h, enzymolysis process remain that agitator speed is 70 revs/min, obtain enzymolysis liquid；
Step 3: the enzymolysis liquid is warming up to 95 DEG C, enzyme deactivation 10 minutes；It is filtered off and is dezymotized with sleeping gong centrifuge after enzyme deactivation
Residue is solved, the revolving speed of decanter centrifuge is 4000r/min；Three-phase centrifuge Purification by filtration is used again, and the revolving speed of three-phase centrifuge is
20000r/min obtains centrifugate；The centrifugate is further concentrated through dual-effect concentrator；After concentrate spray drying, obtain
The powder for treating mastitis for milk cows.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 10 grams of usage amount of ox day is used continuously 3 days.
Relative molecular mass contains in 1000 dalton small-molecular peptides below in the product of the treatment mastitis for milk cows of preparation
Amount is 96.9%, and molecular weight is that the small-molecular peptides content of 180-500 dalton can reach 50.6%.
Embodiment 4
The present embodiment provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 9 parts, 9 parts of Radix Angelicae Sinensis, 2 parts of radix paeoniae rubra, 5 parts of dandelion, 2 parts of folium isatidis, 6 parts of the seed of cowherb, 6 parts of olibanum, 5 parts of Radix Astragali, green peel 1.5
Part and 1 part of Radix Glycyrrhizae.
The preparation method of the powder of above-mentioned treatment mastitis for milk cows includes the following steps:
Step 1: weighing honeysuckle 90Kg, Radix Angelicae Sinensis 90Kg, radix paeoniae rubra 20Kg, dandelion 50Kg, folium isatidis 20Kg, Wang Buliu
Row 60Kg, olibanum 60Kg, Radix Astragali 50Kg, green peel 15Kg and Radix Glycyrrhizae 10Kg are added in 3255L purified water, stir evenly, at 93 DEG C
Under the conditions of, 7.5h is decocted, decoction mixture is obtained；
Step 2: the decoction mixture is cooled to 58 DEG C, be added the amylase of 4.7Kg, 6.9Kg neutral proteinase and
4.2Kg cellulase, stirring enzymatic hydrolysis 3.5h, enzymolysis process remain that agitator speed is 72 revs/min, obtain enzymolysis liquid；
Step 3: the enzymolysis liquid is warming up to 93 DEG C, enzyme deactivation 13 minutes；It is filtered off and is dezymotized with sleeping gong centrifuge after enzyme deactivation
Residue is solved, the revolving speed of decanter centrifuge is 3900r/min；Three-phase centrifuge Purification by filtration is used again, and the revolving speed of three-phase centrifuge is
17000r/min obtains centrifugate；The centrifugate is further concentrated through dual-effect concentrator；After concentrate spray drying, obtain
The powder for treating mastitis for milk cows.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 7.5 grams of usage amount of ox day is used continuously 4 days.
Relative molecular mass contains in 1000 dalton small-molecular peptides below in the product of the treatment mastitis for milk cows of preparation
Amount is 97.4%, and molecular weight is that the small-molecular peptides content of 180-500 dalton can reach 49.6%.
Embodiment 5
The present embodiment provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 8 parts, 3 parts of Radix Angelicae Sinensis, 5 parts of radix paeoniae rubra, 3 parts of dandelion, 5 parts of folium isatidis, 5 parts of the seed of cowherb, 3 parts of olibanum, 6 parts of Radix Astragali, 3 parts of green peel
With 2.5 parts of Radix Glycyrrhizae.
The preparation method of the powder of above-mentioned treatment mastitis for milk cows includes the following steps:
Step 1: weigh honeysuckle 8Kg, Radix Angelicae Sinensis 3Kg, radix paeoniae rubra 5Kg, dandelion 3Kg, folium isatidis 5Kg, seed of cowherb 5Kg,
Olibanum 3Kg, Radix Astragali 6Kg, green peel 3Kg and Radix Glycyrrhizae 2.5Kg are added in 348L purified water, stir evenly, and under the conditions of 94 DEG C, decoct
7h is boiled, decoction mixture is obtained；
Step 2: the decoction mixture is cooled to 57 DEG C, be added the amylase of 522g, 435g neutral proteinase and
348g cellulase, stirring enzymatic hydrolysis 3.5h, enzymolysis process remain that agitator speed is 68 revs/min, obtain enzymolysis liquid；
Step 3: the enzymolysis liquid is warming up to 91 DEG C, enzyme deactivation 14 minutes；It is filtered off and is dezymotized with sleeping gong centrifuge after enzyme deactivation
Residue is solved, the revolving speed of decanter centrifuge is 3700r/min；Three-phase centrifuge Purification by filtration is used again, and the revolving speed of three-phase centrifuge is
18000r/min obtains centrifugate；The centrifugate is further concentrated through dual-effect concentrator；After concentrate spray drying, it must control
Treat the powder of mastitis for milk cows.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 9 grams of usage amount of ox day is used continuously 4 days.
Relative molecular mass contains in 1000 dalton small-molecular peptides below in the product of the treatment mastitis for milk cows of preparation
Amount is 97.4%, and molecular weight is that the small-molecular peptides content of 180-500 dalton can reach 51.5%.
Amylase described in above-described embodiment 1-5 is aspergillus niger amylase, and the neutral proteinase is aspergillus oryzae neutrality egg
White enzyme, the cellulase are Li Shi trichoderma cellulase.
Comparative example 1
This comparative example provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 6 parts, 6 parts of Radix Angelicae Sinensis, 4 parts of radix paeoniae rubra, 4 parts of Fructus Forsythiae, 4 parts of folium isatidis, 4 parts of the seed of cowherb, 4 parts of olibanum, 4 parts of Radix Astragali, 2 parts of green peel and
2 parts of Radix Glycyrrhizae.
The preparation method of above-mentioned treatment mastitis for milk cows powder is same as Example 1.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 7.5 grams of usage amount of ox day is used continuously 4 days.
Comparative example 2
This comparative example provides a kind of powder for treating mastitis for milk cows, the raw material components including following parts by weight: gold and silver
Spend 6 parts, 6 parts of Radix Codonopsis, 4 parts of radix paeoniae rubra, 4 parts of dandelion, 4 parts of folium isatidis, 4 parts of the seed of cowherb, 4 parts of olibanum, 4 parts of Radix Astragali, 2 parts of green peel
With 2 parts of Radix Glycyrrhizae.
The preparation method of above-mentioned treatment mastitis for milk cows powder is same as Example 1.
This product is used as the drug for the treatment of breast inflammation of milk cattle, and every 7.5 grams of usage amount of ox day is used continuously 4 days.
The auxiliary material of field of veterinary routine also may be selected according to routine in the composition for the treatment of mastitis for milk cows provided by the invention
Technique be prepared as granule, decoction, injection, pill or paste.
Application examples 1
Choosing 150 through milking cow by milk cow clinic mastitis diagnostic criteria is subjects, the course of disease 3-7 days, single newborn
56, area, 44, the area Shuan Ru.Clinical symptoms show themselves in that breast is rubescent, oedema, infect newborn area and are hardened, and when palpation breast can find
There is the lump to differ in size, there is ziega or purulent secretion in curdled milk juice.It is disappeared with clinical symptoms such as red, swollen, hot, pains, cream
Juice visually observes normally, and the output of milk is restored, and spirit, appetite are normal, and somatic number drops to normal range (NR) and controls as judgement in milk
More standard.
200 illness milk cows are randomly divided into 4 groups, every group 50, take the drug (embodiment of the embodiment of the present invention 1
Group), Ciprofloxacin Hydrochloride (control group) is taken, the drug (1 group of comparative example) of comparative example 1 is taken, takes the drug of comparative example 2
(2 groups of comparative example), drug is mixed into feed and is fed.The treatment milk cow's milk that the embodiment of the present invention 1 and comparative example 1-2 are prepared
The powder of room inflammation 2 times a day, each 5g；Control group dosage is 2.5mg/Kg, 2 times a day；It is used in conjunction 5 days, test result such as table 1
It is shown.
Table 1
As can be seen from the above table, Chinese medicine composition provided by the invention has breast inflammation of milk cattle cures effect well
Fruit, cure rate can reach 94%.
The average daily output of milk of milk cow is 28.5Kg/ head during test, and the average daily output of milk of comparative example 1 is 20.5Kg/
Head, the average daily output of milk of comparative example 2 are 21.2Kg/ head, and control group is 18.4Kg/ head, and the average daily output of milk of non-illness milk cow is
33.5Kg/ head, also demonstrate using Chinese medicine composition of the invention can effectively reduce the output of milk caused by sick period it is significant under
The appearance of drop problem.
Application examples 2
It randomly selects in milk cattle cultivating factory, Hebei province and is diagnosed as recessive breast through CMT (California, USA mammitis method of inspection)
80 of scorching milk cow.The traditional Chinese powder medicine being prepared using the embodiment of the present invention 1 carries out the recessive mastitis of 80 cow head
Treatment is mixed into feed and feeds or warm water gavages, takes 10g daily, continuous use 5 days, criterion of cure: somatic number was less than 50
Ten thousand/ml.
Test result shows the powder for the treatment of breast inflammation of milk cattle prepared by embodiment 1 to cow subclinical mastitis disease
Cure rate can reach 97.7%, and tracking and monitoring is without recurrence within 6 months.
In conclusion not only living comprising a variety of small molecules in the Chinese medicine composition for the treatment of mastitis for milk cows provided by the invention
Property peptide, chelating peptide, further include a variety of Chinese herbal medicine active components, multivitamin and microelement, can efficiently treat cow breast
Inflammation can be reduced after the additive or without using antibiotic or other medicines additive, antibiotic and chemical synthesis be overcome to add
Add agent to have the defects that residual and side effect, is suitable for being promoted in husbandry sector, has broad application prospects.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of Chinese medicine composition for treating mastitis for milk cows, which is characterized in that the raw material components including following parts by weight: gold
3-9 parts of honeysuckle flower, 3-9 parts of Radix Angelicae Sinensis, 2-6 parts of radix paeoniae rubra, 2-6 parts of dandelion, 2-6 parts of folium isatidis, 2-6 parts of the seed of cowherb, olibanum 2-6
Part, 2-6 parts of Radix Astragali, 1-3 parts and Radix Glycyrrhizae 1-3 parts of green peel.
2. the Chinese medicine composition for the treatment of mastitis for milk cows as described in claim 1, which is characterized in that including following parts by weight
Raw material components: 4-8 parts of honeysuckle, 5-7 parts of Radix Angelicae Sinensis, 3-5 parts of radix paeoniae rubra, 3-5 parts of dandelion, 3-5 parts of folium isatidis, seed of cowherb 3-
5 parts, 3-5 parts of olibanum, 3-5 parts of Radix Astragali, 1.5-2.5 parts and Radix Glycyrrhizae 1.5-2.5 parts of green peel.
3. the Chinese medicine composition for the treatment of mastitis for milk cows as claimed in claim 2, which is characterized in that including following parts by weight
Raw material components: 6 parts of honeysuckle, 6 parts of Radix Angelicae Sinensis, 4 parts of radix paeoniae rubra, 4 parts of dandelion, 4 parts of folium isatidis, 4 parts of the seed of cowherb, 4 parts of olibanum,
4 parts of Radix Astragali, 2 parts and 2 parts of Radix Glycyrrhizae of green peel.
4. the Chinese medicine composition for the treatment of mastitis for milk cows as described in any one of claims 1-3, which is characterized in that its preparation side
Method the following steps are included:
Step 1: according to design proportion weigh honeysuckle, Radix Angelicae Sinensis, radix paeoniae rubra, dandelion, folium isatidis, the seed of cowherb, olibanum, Radix Astragali,
Green peel and Radix Glycyrrhizae are added 7-8 times of purified water of raw material weight, stir evenly, and in 90-95 DEG C of decoction 7-8h, must decoct mixing
Object；
Step 2: the decoction mixture is cooled to 56-58 DEG C, amylase, neutral proteinase and cellulase, stirring is added
3-4h is digested, enzymolysis liquid is obtained；
Step 3: the enzymolysis liquid heat temperature raising is carried out enzyme-deactivating, isolate and purify, is concentrated, it is dry, obtain treatment mastitis for milk cows
Chinese medicine composition.
5. the Chinese medicine composition for the treatment of mastitis for milk cows as claimed in claim 4, which is characterized in that in step 2, the shallow lake
The additional amount of powder enzyme is the 1-1.5% of raw material weight, and the additional amount of the neutral proteinase is the 1-1.5% of raw material weight, institute
The additional amount for stating cellulase is the 0.8-1.2% of raw material weight.
6. the Chinese medicine composition for the treatment of mastitis for milk cows as described in claim 4 or 5, which is characterized in that the amylase is
Aspergillus niger amylase；And/or
The neutral proteinase is aspergillus oryzae neutral proteinase；And/or
The cellulase is Li Shi trichoderma cellulase.
7. the Chinese medicine composition for the treatment of mastitis for milk cows as claimed in claim 4, which is characterized in that, will be described in step 3
Enzymolysis liquid is heated to 90-95 DEG C, keeps the temperature 10-15 minutes progress enzyme-deactivatings.
8. the Chinese medicine composition for the treatment of mastitis for milk cows as claimed in claim 4, which is characterized in that isolated and purified in step 3
The step of specifically: the enzymolysis liquid after inactivation is successively centrifuged through decanter centrifuge and three-phase centrifuge.
9. a kind of drug for treating mastitis for milk cows, which is characterized in that including the described in any item treatment milk cows of claim 1-8
The Chinese medicine composition of mammitis.
10. as claimed in claim 9 treatment mastitis for milk cows drug, which is characterized in that its dosage form be powder, granule,
Decoction, tablet, injection, pill or paste.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403084A (en) * | 2019-08-19 | 2019-11-05 | 河北肽都生物科技有限公司 | A kind of raising milk production of cow and the Chinese medicine complex peptides of milk quality and its preparation method and application |
| CN114146110A (en) * | 2021-12-16 | 2022-03-08 | 塔里木大学 | Pharmaceutical preparation for treating cow mastitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560777A (en) * | 2014-10-14 | 2016-05-11 | 天津中敖生物科技有限公司 | Chinese medicinal composition for treatment of cow mastitis and preparation method thereof |
-
2018
- 2018-12-28 CN CN201811624975.6A patent/CN109498709A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560777A (en) * | 2014-10-14 | 2016-05-11 | 天津中敖生物科技有限公司 | Chinese medicinal composition for treatment of cow mastitis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 杜冬华 等: "中药方剂治疗奶牛隐性乳房炎的疗效试验", 《中国兽医杂志》 * |
| 杜冬华 等: "自拟中药方对奶牛隐性乳房炎的疗效试验", 《动物医学进展》 * |
| 罗永明: "《天然药物化学》", 31 August 2011, 华中科技大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403084A (en) * | 2019-08-19 | 2019-11-05 | 河北肽都生物科技有限公司 | A kind of raising milk production of cow and the Chinese medicine complex peptides of milk quality and its preparation method and application |
| CN114146110A (en) * | 2021-12-16 | 2022-03-08 | 塔里木大学 | Pharmaceutical preparation for treating cow mastitis and preparation method thereof |
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