CN1256967C - Health-preserving liver-protecting drug and method for making same - Google Patents
Health-preserving liver-protecting drug and method for making same Download PDFInfo
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- CN1256967C CN1256967C CN 03101960 CN03101960A CN1256967C CN 1256967 C CN1256967 C CN 1256967C CN 03101960 CN03101960 CN 03101960 CN 03101960 A CN03101960 A CN 03101960A CN 1256967 C CN1256967 C CN 1256967C
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- rhizoma alismatis
- schisandrae chinensis
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Abstract
The present invention discloses new health preservation liver protection medicine. Gynostemma pentaphylla, haw, wolfberry fruit, bupleurum roots, water plantain, schisandra fruit and pueraria roots are used as raw materials, according to different characteristics of each traditional Chinese medicine, and after the raw materials are respectively pretreated in the mode of pulverization, stock cutting, aqueous extract, etc. The raw materials are prepared proportionally; granules are made by drying and sterization. The present invention has the advantages of unique formula and manufacture method and significant therapeutic effect.
Description
Technical field
Originally relate to invention and a kind of health preserving liver protection medicine and preparation method thereof.Be the Chinese patent medicine of feedstock production specifically, the invention still further relates to the preparation method of this medicine with the Chinese herbal medicine.
Background technology
China has long spirits culture history, and under this big environmental background, makes warmhearted and hospitable Chinese mostly have the custom of drinking, and changes between small cup pushing away cup, when the amount of having is many unavoidably, and drinks each time, and what damage was maximum has been exactly liver.The drunk deeply hepatitis that once just equals one time of the people of saying on the books, and the hepatic injury that is now caused by wine is to increase year by year.And because other relevant chronic diseases that hepatic injury caused are just more.
Liver is the substantive digestive organs of human body maximum, and various nutrient substance are transformed into protein, lipid and the glycogen of biologically active, thereby has ensured the functional activity of internal organs such as human body each organ, the especially heart, brain, kidney.
At present domestic still is a blank in the middle of the development of health preserving liver protection medicine, neither one good effect, instant effect taking convenience, the medicine of being free from side effects.
Summary of the invention
The purpose of this invention is to provide medicine of a kind of health preserving liver protection and preparation method thereof, remove the caused dizziness in back of drinking, headache, feel sick, vomiting, lethargy, particularly second day weak and effectively prevent alcoholic fatty liver, the adverse consequencess such as other serial chronic disease that the alcoholic liver injury alcoholic fatty liver caused.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to the liver maintenance, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, to filter out that heat clearing away is relieved the effect of alcohol, removing dampness is dispelled turbid, the homologous natural edible-plant medicine of medicated diet of suppressing the hyperactive liver and subsiding YANG, the strong liver of the kidney invigorating of nourishing heart, by the theory of Chinese medical science prescription, skim the cream off milk, alleviate and opposing liver caused various undesirable elements when metabolism is taken in because of ethanol.Reduce the hepatic injury cause because of drinking, play relieve the effect of alcohol, multi-efficiency such as hepatoprotective.
Medicine of the present invention is made by following materials of weight proportions or is made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the water extract of following weight proportion raw material by the alcohol extract of following weight proportion raw material:
Herba Gynostemmatis 10--25 part Fructus Crataegi 10--20 part Fructus Lycii 10--20 part
Radix Bupleuri 5--15 part Rhizoma Alismatis 5--15 part Fructus Schisandrae Chinensis 8--20 part
Radix Puerariae 5--15 part
Wherein, having another name called of Herba Gynostemmatis, be Herb Gynostemmae Pentaphylli.
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Herba Gynostemmatis 10--20 part Fructus Crataegi 10--15 part Fructus Lycii 10--15 part
Radix Bupleuri 5--10 part Rhizoma Alismatis 5--10 part Fructus Schisandrae Chinensis 10--15 part
Radix Puerariae 5--15 part
The optimum weight proportioning of medicine of the present invention is:
5 parts of 10 parts of Radix Bupleuri of 10 parts of Fructus Lycii of 15 portions of Fructus Crataegis of Herba Gynostemmatis
10 parts of 8 parts of Radix Puerariaes of 5.5 parts of Fructus Schisandrae Chinensis of Rhizoma Alismatis
The medicament of medicine of the present invention is a said dosage form on any pharmaceutics.
The preferred agents of medicine of the present invention is an electuary.
A kind of method for preparing the medicine of health preserving liver protection, this method comprises the following steps:
(1) Chinese crude drug that takes by weighing following weight proportion is made raw material:
Herba Gynostemmatis 10--25 part Fructus Crataegi 10--20 part Fructus Lycii 10--20 part
Radix Bupleuri 5--15 part Rhizoma Alismatis 5--15 part Fructus Schisandrae Chinensis 8--20 part
Radix Puerariae 5--15 part;
(2) get Herba Gynostemmatis, Fructus Crataegi, Fructus Lycii, Rhizoma Alismatis, Radix Bupleuri water intaking decocting liquid concentrates, and obtains water extracting liquid;
(3) Fructus Schisandrae Chinensis extracts with alcoholic solution, removes slag to extract to concentrate, and obtains the alcohol extraction concentrated solution;
(4) get Radix Puerariae drying and crushing to 60 order coarse powder;
(5) concentrated solution of the concentrated solution of step (2), step (3) and Radix Puerariae are mixed after spray drying again, make former medicine dry powder;
(6) getting former medicine dry powder adds the equivalent dextrin and granulates and to form finished product.
In the method for the medicine of above-mentioned preparation health preserving liver protection, be to adopt alcohol extraction and water to put forward the method that combines, be preferable methods.The also method that can all adopt water to carry, or all adopt the method for alcohol extraction.
An important feature of the present invention is to contain abundant nutrition in the medicament, contains multiple Saponin, organic acid, glucosamine and polysaccharide.Wherein only one of Herba Gynostemmatis just contains 80 kinds of Saponins.These nutritions all can play the better protect effect to alcoholic liver injury.
Each nutrition content sees the following form in the medicine of the present invention:
| Title | Content (mg/100g) | Title | Content (mg/100g) | Title | Content (mg/100g) |
| Saponin | 1214.3 | Polysaccharide | 1559.6 | Organic acid | 281.9 |
| Aminoacid | 1117.0 | Alkaloid | 359.5 | Flavonoid | 378.2 |
Also contain various trace elements such as vitamin C, vitamin E, vitamin B6, calcium, phosphorus, ferrum, zinc and folic acid in the medicament of health preserving liver protection of the present invention in addition, these vitamin are prothetic groups of body repair cell, can promote to relieve the effect of alcohol the protection hepatocyte.
Various chemical element contents see the following form in the medicine of the present invention:
| Title | Content (mg/100g) | Title | Content (mg/100g) | Title | Content (mg/100g) |
| Calcium | 1178 | Zinc | 17.81 | Dimension C | 88 |
| Phosphorus | 1033 | Ferrum | 68.1 | Dimension B6 | 0.28 |
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select the homologous natural edible-plant medicine of medicated diet for use be raw material in invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function health preserving liver protection of Chinese medicine.No chemical addition agent, nontoxic to human body.
2, the present invention need not decoct, no bitterness sense.Nutritious.All drinkable after drinking before the wine, taking convenience.Meet state food health legislation regulation.
3, the present invention can use separately, also can cooperate other drug that fatty liver and hyperlipidaemic conditions are all had certain curative effect.
For showing the therapeutic effect of medicine of the present invention to health preserving liver protection, the present invention is through the clinical observation of 100 routine systems, and select all ages and classes, sex, degree, the state of an illness and time and do not use 32 routine alcohol users of Therapeutic Method to be matched group, from being in hospital and outpatient service selection case.With the alcoholic fatty liver is observation caliber.Wherein male 61 examples, women 39 examples.27～65 years old age.The course of disease 1 year～30 years.Experimental group, on former treatment basis, the lipid lowerers of stopping using.Take medicine of the present invention.Matched group: protect the liver routinely, blood fat reducing treatment.Wherein other kind, usage, consumption and experimental group of taking medicine is complementary, and lipid lowerers adopts the import fenofibrate.Adopt same procedure to make regular check on fasting plasma lipid and transaminase.Observed three months, one month is a course of treatment, totally three courses of treatment.
Instructions of taking: 5 grams/time, day clothes three times.Boiled water brews to be drunk.Clinical test results such as table 1
Table 1 is taken the variation of transaminase's content in the blood of medicine of the present invention front and back
| Case load | AST/ALT | γ glutamyl transpeptidase (the μ mol/L of γ-GT) | Glycocholic acid mg/L | ||||
| Before | After | Before | After | Before | After | ||
| Test group | 89 | 2.3 | 1.6 | 240±52.5 | 120±45.5 | 3258±50.2 | 1335±19.2 |
| Matched group | 25 | 2.4 | 1.8 | 250±41.6 | 200±51.5 | 3125±34.3 | 2341±26.7 |
| t | 0.29 | 10.32 | 0.16 | 8.74 ＜0.01 | |||
| p | ＞0.05 | ＜0.01 | ＞0.05 | ||||
Table 1 data show, it is basic identical to treat preceding two groups hepatocellular damage degree, take medicine of the present invention after, liver function is clearly better, and uses the liver function recovery of matched group of blood fat reducing class medicine undesirable.
Test statistics shows: with medicament of the present invention the patient of 100 health preserving liver protections is done therapeutic test, that obtains significant curative effect accounts for 56%, substantially effectively accounts for 41%, and invalid accounts for 2%, and total effective rate reaches 98.3%.(AST/ALT is not more than 2 and recovers for basic, γ-GT should less than 40IU/L)
The specific embodiment
Embodiment 1
Take by weighing raw material by following proportioning:
Herba Gynostemmatis 15g Fructus Crataegi 10g Fructus Lycii 10g Radix Bupleuri 5g
Rhizoma Alismatis 5g Fructus Schisandrae Chinensis 8g Radix Puerariae 5g
Get Herba Gynostemmatis, Fructus Crataegi, Fructus Lycii, Rhizoma Alismatis, Radix Bupleuri, boil with the decocting of 300g, reconcentration obtains water extracting liquid;
Getting Fructus Schisandrae Chinensis concentration is that 60% edible alcohol solution soaked ten days, removes slag, separates ethanol, will extract concentrated solution, obtains the alcohol extraction concentrated solution;
Get Radix Puerariae drying and crushing to 60 order coarse powder;
Spray drying again after the concentrated solution of the concentrated solution of the above-mentioned Herba Gynostemmatis of strand, Fructus Crataegi, Fructus Lycii, Rhizoma Alismatis, Radix Bupleuri, Fructus Schisandrae Chinensis and Radix Puerariae mixed makes former medicine dry powder;
Get former medicine dry powder and add the equivalent dextrin and granulate and to form, pack then, cobalt-60 irradiation makes the electuary finished product.
Embodiment 2
Take by weighing raw material by following proportioning:
Herba Gynostemmatis 25g Fructus Crataegi 20g Fructus Lycii 20g
Radix Bupleuri 15g Rhizoma Alismatis 15g Fructus Schisandrae Chinensis 20g Radix Puerariae 15g
Above-mentioned each raw material is boiled three times with the decocting of 600g respectively, decocted 2 hours at every turn, reconcentration after the merging decoction liquor obtains water extracting liquid;
With above-mentioned concentrated solution and dextrin mix homogeneously, spray granulation makes the electuary finished product again.
Embodiment 3
Take by weighing raw material by following proportioning:
Herba Gynostemmatis 10g Fructus Crataegi 10g Fructus Lycii 10g Radix Bupleuri 5g
Rhizoma Alismatis 5g Fructus Schisandrae Chinensis 8g Radix Puerariae 5g
With above-mentioned each raw material concentration is after 60% edible alcohol solution soaks one day, to put into reflux, and reflux 3 hours obtains alcohol extract;
With above-mentioned alcohol extract and dextrin mix homogeneously, spray granulation makes the electuary finished product again.
Claims (7)
1, a kind of medicine of health preserving liver protection is characterized in that: make active component raw material and consist of:
Herba Gynostemmatis 10-25 part Fructus Crataegi 10-20 part Fructus Lycii 10-20 part
Radix Bupleuri 5-15 part Rhizoma Alismatis 5-15 part Fructus Schisandrae Chinensis 8-20 part
Radix Puerariae 5-15 part.
2, a kind of medicine of health preserving liver protection is characterized in that: it makes active component by the alcohol extract of following weight proportion raw material and pharmaceutically acceptable additives are formed:
Herba Gynostemmatis 10-25 part Fructus Crataegi 10-20 part Fructus Lycii 10-20 part
Radix Bupleuri 5-15 part Rhizoma Alismatis 5-15 part Fructus Schisandrae Chinensis 8-20 part
Radix Puerariae 5-15 part.
3, a kind of medicine of health preserving liver protection is characterized in that: it makes active component by the water extract of following weight proportion raw material and pharmaceutically acceptable additives are formed:
Herba Gynostemmatis 10-25 part Fructus Crataegi 10-20 part Fructus Lycii 10-20 part
Radix Bupleuri 5-15 part Rhizoma Alismatis 5-15 part Fructus Schisandrae Chinensis 8-20 part
Radix Puerariae 5-15 part.
4, the medicine of health preserving liver protection according to claim 1 is characterized in that: the weight proportion of each raw material is:
Herba Gynostemmatis 10-20 part Fructus Crataegi 10-15 part Fructus Lycii 10-15 part
Radix Bupleuri 5-10 part Rhizoma Alismatis 5-10 part Fructus Schisandrae Chinensis 10-15 part
Radix Puerariae 5-15 part.
5, the medicine of health preserving liver protection according to claim 1 is characterized in that: the weight proportion of each raw material is:
5 parts of 10 parts of Radix Bupleuri of 10 parts of Fructus Lycii of 15 portions of Fructus Crataegis of Herba Gynostemmatis
10 parts of 8 parts of Radix Puerariaes of 5.5 parts of Fructus Schisandrae Chinensis of Rhizoma Alismatis.
6, according to the medicine of claim 2 or 3 described health preserving liver protections, it is characterized in that: the medicament of said medicine is an electuary.
7, a kind of method for preparing the medicine of health preserving liver protection, it is characterized in that: this method is made up of the following step:
(1) Chinese crude drug that takes by weighing following weight proportion is made raw material:
Herba Gynostemmatis 10-25 part Fructus Crataegi 10-20 part Fructus Lycii 10-20 part
Radix Bupleuri 5-15 part Rhizoma Alismatis 5-15 part Fructus Schisandrae Chinensis 8-20 part
Radix Puerariae 5-15 part;
(2) get Herba Gynostemmatis, Fructus Crataegi, Fructus Lycii, Rhizoma Alismatis, Radix Bupleuri water intaking decocting liquid concentrates, and obtains water extracting liquid;
(3) Fructus Schisandrae Chinensis extracts with alcoholic solution, removes slag to extract to concentrate, and obtains the alcohol extraction concentrated solution;
(4) get Radix Puerariae drying and crushing to 60 order coarse powder;
(5) concentrated solution of the concentrated solution of step (2), step (3) and Radix Puerariae are mixed after spray drying again, make former medicine dry powder;
(6) getting former medicine dry powder adds the equivalent dextrin and granulates and to form finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03101960 CN1256967C (en) | 2003-01-30 | 2003-01-30 | Health-preserving liver-protecting drug and method for making same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03101960 CN1256967C (en) | 2003-01-30 | 2003-01-30 | Health-preserving liver-protecting drug and method for making same |
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| Publication Number | Publication Date |
|---|---|
| CN1520831A CN1520831A (en) | 2004-08-18 |
| CN1256967C true CN1256967C (en) | 2006-05-24 |
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| CN 03101960 Expired - Lifetime CN1256967C (en) | 2003-01-30 | 2003-01-30 | Health-preserving liver-protecting drug and method for making same |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036691B (en) * | 2007-04-11 | 2010-05-19 | 张金桦 | Health-caring product for improving bone density and immunity |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293304B (en) * | 2011-09-20 | 2013-02-13 | 福建华尔康生物科技有限公司 | Flavone-containing instant tea and preparation method thereof |
| CN102613366A (en) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | Anti-alcoholic tea and preparation method thereof |
| CN102669667B (en) * | 2012-05-25 | 2013-07-17 | 北京三奇本草医药技术有限公司 | Health food with dual functions of protecting liver and adjusting blood fat and preparation method thereof |
| CN103055189B (en) * | 2013-02-18 | 2014-09-03 | 瑞安市视尚光学眼镜科技有限公司 | Traditional Chinese medicine composition with antialcoholism efficacy |
| CN103169823B (en) * | 2013-04-18 | 2014-09-24 | 四川农业大学 | Veterinary drug composition for preventing and controlling mycotoxicoses as well as application, preparation and preparation method of veterinary drug composition |
| CN104643201A (en) * | 2014-06-10 | 2015-05-27 | 吴冬刚 | Anti-alcoholism beverage |
| CN106421480A (en) * | 2016-11-10 | 2017-02-22 | 刘大仟 | Traditional Chinese medicinal formula for treating hepatitis B |
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2003
- 2003-01-30 CN CN 03101960 patent/CN1256967C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036691B (en) * | 2007-04-11 | 2010-05-19 | 张金桦 | Health-caring product for improving bone density and immunity |
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| CN1520831A (en) | 2004-08-18 |
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Assignee: BEIJING SANQI MEDICAL TECHNOLOGY Research Institute Assignor: Wang Xiao Contract record no.: 2011990000816 Denomination of invention: Health-preserving liver-protecting drug and method for making same Granted publication date: 20060524 License type: Exclusive License Open date: 20040818 Record date: 20110824 |
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| CX01 | Expiry of patent term |
Granted publication date: 20060524 |