CN1256977C - Health-preserving brain-supplementing medicine and its preparation method - Google Patents

Abstract

The present invention discloses a health-preservation health care medicine for nourishing the brain and improving memory and a preparation method of the health-preservation health care medicine. 5 to 20 portions of acanthopanax roots, 5 to 15 portions of grosvenor momordica fruits, 10 to 20 portions of wolfberry fruits, 5 to 15 portions of gynostemma pentaphylla, 5 to 15 portions of fructus alpiniae oxyphyllae, 5 to 15 portions of dogwood fruits, 1 to 10 portions of red sage roots and 1 to 10 portions of cinnamon are used as raw materials, and the health-preservation health care medicine for nourishing the brain and improving memory is made by the steps of water extraction and condensation, alcohol extraction and condensation, pulverization, mist spraying and drying, granulation, etc. The medicine of the present invention has the efficiency of brain nourishment, intelligence benefiting, improvement of pars encephalica affections and memory barrier, such as memory decline caused by excessive cerebration or senile encephalatrophy, etc. and significant therapeutic effect.

Description

Health preserving supplementing the brain medicine and preparation method thereof

Technical field

Originally relate to invention and a kind of health preserving supplementing the brain medicine and preparation method thereof.Specifically be that the prepared supplementing the brain of raw material improves Chinese patent medicine of remembering health care and preparation method thereof with the Chinese herbal medicine.

Background technology

In the historical long river of human development, supplementing the brain, brain-strengthening improve memory, and the utilization rate that improves human brain is the target that we pursued always.Now developed country and developing country all are faced with problems such as aged tendency of population, the hypomnesis that causes so how to improve brain overwork, and the problem of the senile hypomnesis that causes because of brain atrophy just seems particularly important.

Brain is the finest and close organ of human body, and the set that is the health nervus centralis also is the material base of thinking activities.Exactly because the growth of mankind's brain just is different from other organism, becomes intelligent part of the universe, created the brilliant civilization of today.

At present domestic still is a blank in the middle of the development of supplementing the brain improvement memory, goes back the neither one good effect, instant effect, taking convenience, the medicine of the supplementing the brain brain-strengthening that has no side effect.

Summary of the invention

The purpose of this invention is to provide a kind of health preserving supplementing the brain medicine.Have supplementing the brain, Fructus Alpiniae Oxyphyllae, improve the effect of the loyal and memory disorder of the brain diseases such as hypomnesis that cause because of brain overwork or senile encephalatrophy.

Another object of the present invention provides a kind of preparation method of health preserving supplementing the brain medicine.

For achieving the above object, the present invention takes following technical scheme:

A kind of health preserving supplementing the brain medicine, it is made by following materials of weight proportions or makes active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the water extract of following weight proportion raw material by the alcohol extract of following weight proportion raw material:

Radix Et Caulis Acanthopanacis Senticosi 5-20 part Fructus Momordicae 5-15 part Fructus Lycii 10-20 part

Herb Gynostemmae Pentaphylli 5-15 part Fructus Alpiniae Oxyphyllae 5-15 part Fructus Corni 5-15 part

Radix Salviae Miltiorrhizae 1-10 part Cortex Cinnamomi 1-10 part

Technical scheme of the present invention is based on understanding and the Therapeutic Principle that motherland's medical science is improved memory to supplementing the brain, Fructus Alpiniae Oxyphyllae, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out the homologous natural edible-plant medicine of medicated diet of nourishing blood to tranquillize the mind, the long intelligence of tonify deficiency, the Fructus Alpiniae Oxyphyllae of calming the nerves, appetizing strengthening the spleen, by the theory of Chinese medical science prescription, skim the cream off milk, alleviate and hypomnesis that hypomnesis that opposing causes because of brain overwork for a long time or senile encephalatrophy cause, and have multi-efficiencies such as supplementing the brain, Fructus Alpiniae Oxyphyllae.

In health preserving supplementing the brain medicine of the present invention, the preferred version of the weight proportion of each raw material is:

Radix Et Caulis Acanthopanacis Senticosi 10-15 part Fructus Momordicae 5-10 part Fructus Lycii 10-15 part

Herb Gynostemmae Pentaphylli 5-10 part Fructus Alpiniae Oxyphyllae 5-10 part Fructus Corni 5-10 part

Radix Salviae Miltiorrhizae 1-5 part Cortex Cinnamomi 1-5 part.

In health preserving supplementing the brain medicine of the present invention, the most preferably scheme of the weight proportion of each raw material is:

9 parts of 14 portions of Herb Gynostemmae Pentaphylli of 9 parts of Fructus Lycii of 15 portions of Fructus Momordicaes of Radix Et Caulis Acanthopanacis Senticosi

5 parts of 5 portions of Cortex Cinnamomis of 7 parts of Radix Salviae Miltiorrhizaes of 9 parts of Fructus Corni of Fructus Alpiniae Oxyphyllae.

The medicament of health preserving supplementing the brain medicine of the present invention is a said dosage form on any pharmaceutics.

The pharmacy optimization of health preserving supplementing the brain medicine of the present invention is an electuary.

A kind of method for preparing health preserving supplementing the brain medicine of the present invention, this method comprises the following steps:

(1) Chinese crude drug that takes by weighing following weight proportion is made raw material:

Radix Et Caulis Acanthopanacis Senticosi 5-20 part Fructus Momordicae 5-15 part Fructus Lycii 10-20 part

Herb Gynostemmae Pentaphylli 5-15 part Fructus Alpiniae Oxyphyllae 5-15 part Fructus Corni 5-15 part

Radix Salviae Miltiorrhizae 1-10 part Cortex Cinnamomi 1-10 part;

(2) get Herb Gynostemmae Pentaphylli, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Cortex Cinnamomi, Fructus Corni, Fructus Momordicae decocting, and decocting liquid is concentrated, obtain water extracting liquid;

(3) get Radix Et Caulis Acanthopanacis Senticosi and extract with alcoholic solution, removing slag to extract concentrates, and obtains the alcohol extraction concentrated solution;

(4) get Radix Salviae Miltiorrhizae drying and crushing to 60 order coarse powder;

(5) concentrated solution of the concentrated solution of step (2), step (3) and Radix Salviae Miltiorrhizae are mixed after again spray drying, granulating to form makes former medicine dry powder;

(6) former medicine dry powder is added the granulation of equivalent dextrin and form finished product.

An important feature of the present invention is to contain abundant nutrition in the medicine, contains multiple Saponin, aminoacid, flavonoid glycoside, organic acid, fructose and polysaccharide.Wherein only just contain the Saponin more than 13% in the Fructus Corni pulp, also contain tens kinds of organic acid and unsaturated fatty acid in the pit, contain a large amount of triterpenoid saponin and tens seed amino acids in the Fructus Momordicae.These nutritions can be regulated cerebral cortex excitement and process of inhibition, promote the renewal and the generation of brain cell, improve memory function.Each nutrition content sees the following form 1 in the medicine of the present invention:

Table 1

Title	Content (mg/100g)	Title	Content (mg/100g)	Title	Content (mg/100g)
						Saponin	3214.3	Polysaccharide	2559.6	Organic acid	378.2
Aminoacid	2117.0	Esters	359.5	Flavonoid	281.9

Supplementing the brain of the present invention in addition improves in the medicine of memory and also contains the various trace elements such as rope C, vitamin E, vitamin B, selenium, calcium, phosphorus, ferrum, zinc and folic acid, taurine of supporting one's family; these vitamin are prothetic groups of body repair cell; also be that the nutrition cerebral cortex promotes cell to upgrade, help supplementing the brain, Fructus Alpiniae Oxyphyllae to improve memory.Various chemical element contents see the following form 2 in the medicine of the present invention:

Table 2

Title	Content (mg/100g)	Title	Content (mg/100g)	Title	Content (mg/100g)
						Calcium	2178	Zinc	17.81	Dimension C	88
Phosphorus	1033	Ferrum	68.1	Dimension B	1.28

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, to select the homologous natural edible-plant medicine of medicated diet for use be raw material in invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function brain-nourishing intelligence-benefiting of Chinese medicine to improve memory.No chemical addition agent, nontoxic to human body.

2, the present invention need not decoct, no bitterness sense.Nutritious.The boiled water whole day of taking after mixing it with water is all drinkable, taking convenience.Meet state food health legislation regulation.

3, the present invention can use separately, also can cooperate other drug that diseases such as senile encephalatrophy and senile dementia are all had certain curative effect.

For showing that medicine of the present invention improves the therapeutic effect of memory to brain-nourishing intelligence-benefiting, the present invention is through the patient system clinical observation of 100 routine hypomnesis brain agings, and selection all ages and classes, sex, degree, the state of an illness and time, wherein, it is not use the patient of the hypomnesis brain aging of Therapeutic Method that 32 examples are arranged, and is from the case of being in hospital and outpatient service is selected.Reveal any symptoms with the aging of hypomnesis brain is an observation caliber.Wherein male 61 examples, women 39 examples.Age 45-75 year.The course of disease 1 year-10 years.Experimental group on former treatment basis, is taken medicine of the present invention.Matched group: routinely supplementing the brain, take good care of treatment.Wherein matched group usage, consumption and the experimental group of taking other drug kind usage, the consumption of taking medicine of the present invention is complementary.Adopt the regular inquiry of same procedure, system's physical examination, pulse wave spectrum.

The diagnostic criteria of the old and feeble disease of hypomnesis brain is to be diagnostic criteria with its reveal any symptoms, and its reveal any symptoms is symptoms such as ergasia is slow, absent minded, vertigo and tinnitus, insomnia agitation.

Observed three months, one month is a course of treatment, totally three courses of treatment.

Instructions of taking: 3 grams/time, day clothes three times.Boiled water is taken after mixing it with water.Clinical test results such as table 3

Table 3 is taken the variation of medicine of the present invention front and back symptom

	Case load	Ergasia is slow		Absent minded		Vertigo and tinnitus		Insomnia is irritated
										Before	After	Before	After	Before	After	Before	After
		Test group	73	69	45	73	51	58	39									61	31
Matched group	27									25	22	27	23	22	20	26	25

Table 1 data show, treat preceding two groups hypomnesis and pulse-taking after degree basic identical, take medicine of the present invention after, the mental status is clearly better, and uses every situation of the matched group of medicine to recover undesirable.

Test statistics shows: with medicament of the present invention the patient of 100 hypomnesis brains aging is done therapeutic test, that obtains significant curative effect accounts for 56%, substantially effectively accounts for 41%, and invalid accounts for 2%, and total effective rate reaches 98.3%.

Criterion of therapeutical effect is carried out efficacy evaluation with the improvement degree of one-tenth of the reveal any symptoms of the old and feeble disease of hypomnesis brain, recalls the obvious improver of reveal any symptoms that power goes down the old and feeble disease of brain, is significant curative effect; Recall the reveal any symptoms alleviation person that power goes down the old and feeble disease of brain, for effective substantially; Recalling the go down reveal any symptoms of the old and feeble disease of brain of power does not have the improver, for invalid.

The specific embodiment

Embodiment 1

Take off the Chinese crude drug of column weight amount proportioning and make raw material:

Radix Et Caulis Acanthopanacis Senticosi 15g Fructus Momordicae 9g Fructus Lycii 14g Herb Gynostemmae Pentaphylli 9g

Fructus Alpiniae Oxyphyllae 9g Fructus Corni 7g Radix Salviae Miltiorrhizae 5g Cortex Cinnamomi 5g

Get Herb Gynostemmae Pentaphylli, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Cortex Cinnamomi, Fructus Corni, the Fructus Momordicae of above-mentioned weight, boil with the decocting of 500g, reconcentration obtains water extracting liquid;

Radix Et Caulis Acanthopanacis Senticosi concentration is that 60% edible alcohol solution soaked ten days, removes slag, and separates ethanol extracting solution is concentrated, and obtains the alcohol extraction concentrated solution;

Get Radix Salviae Miltiorrhizae drying and crushing to 60 order coarse powder;

After the concentrated solution of the concentrated solution of Herb Gynostemmae Pentaphylli, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Cortex Cinnamomi, Fructus Corni, Fructus Momordicae, Radix Et Caulis Acanthopanacis Senticosi and Radix Salviae Miltiorrhizae mixed again spray drying, granulating to form makes former medicine dry powder;

Get former medicine dry powder and add the equivalent dextrin and granulate and to form, pack then, cobalt-60 irradiation makes the electuary finished product.

Embodiment 2

Take by weighing raw material by following proportioning:

Radix Et Caulis Acanthopanacis Senticosi 20g Fructus Momordicae 15g Fructus Lycii 20g Herb Gynostemmae Pentaphylli 15g

Fructus Alpiniae Oxyphyllae 15g Fructus Corni 15g Radix Salviae Miltiorrhizae 10g Cortex Cinnamomi 10g.

Above-mentioned each raw material is boiled three times with the decocting of 800g, 600g, 600g respectively, decocted 2 hours at every turn, reconcentration after the merging decoction liquor obtains water extracting liquid;

With above-mentioned concentrated solution and dextrin mix homogeneously, granulate with spray granulation, pack then, cobalt-60 irradiation makes the electuary finished product.

Embodiment 3

Take by weighing raw material by following proportioning:

Radix Et Caulis Acanthopanacis Senticosi 5g Fructus Momordicae 5g Fructus Lycii 10g Herb Gynostemmae Pentaphylli 5g

Fructus Alpiniae Oxyphyllae 5g Fructus Corni 5g Radix Salviae Miltiorrhizae 3g Cortex Cinnamomi 3g.

With above-mentioned each raw material concentration is that 80% edible alcohol solution soaked 15 days, removes slag, separates ethanol extracting solution is concentrated, and obtains the alcohol extraction concentrated solution;

With above-mentioned concentrated solution and dextrin mix homogeneously, granulate with spray granulation, pack then, cobalt-60 irradiation makes the electuary finished product.

Embodiment 1, embodiment 2 and embodiment 3 made electuaries can both reach therapeutic effect of the present invention.

Claims (5)

1, a kind of health preserving supplementing the brain medicine is characterized in that: it is made by following materials of weight proportions or makes active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the water extract of following weight proportion raw material by the alcohol extract of following weight proportion raw material:

Radix Et Caulis Acanthopanacis Senticosi 5-20 part Fructus Momordicae 5-15 part Fructus Lycii 10-20 part

Herb Gynostemmae Pentaphylli 5-15 part Fructus Alpiniae Oxyphyllae 5-15 part Fructus Corni 5-15 part

Radix Salviae Miltiorrhizae 1-10 part Cortex Cinnamomi 1-10 part.

2, health preserving supplementing the brain medicine according to claim 1, it is characterized in that: the weight proportion of each raw material is:

Radix Et Caulis Acanthopanacis Senticosi 10-15 part Fructus Momordicae 5-10 part Fructus Lycii 10-15 part

Herb Gynostemmae Pentaphylli 5-10 part Fructus Alpiniae Oxyphyllae 5-10 part Fructus Corni 5-10 part

Radix Salviae Miltiorrhizae 1-5 part Cortex Cinnamomi 1-5 part.

3, health preserving supplementing the brain medicine according to claim 2, it is characterized in that: the weight proportion of each raw material is:

9 parts of 14 portions of Herb Gynostemmae Pentaphylli of 9 parts of Fructus Lycii of 15 portions of Fructus Momordicaes of Radix Et Caulis Acanthopanacis Senticosi

5 parts of 5 portions of Cortex Cinnamomis of 7 parts of Radix Salviae Miltiorrhizaes of 9 parts of Fructus Corni of Fructus Alpiniae Oxyphyllae.

4, health preserving supplementing the brain medicine according to claim 1, it is characterized in that: the medicament of described medicine is an electuary.

5, a kind of method for preparing health preserving supplementing the brain medicine, it is characterized in that: this method comprises the following steps:

(1) Chinese crude drug that takes by weighing following weight proportion is made raw material:

Radix Et Caulis Acanthopanacis Senticosi 5-20 part Fructus Momordicae 5-15 part Fructus Lycii 10-20 part

Herb Gynostemmae Pentaphylli 5-15 part Fructus Alpiniae Oxyphyllae 5-15 part Fructus Corni 5-15 part

Radix Salviae Miltiorrhizae 1-10 part Cortex Cinnamomi 1-10 part;

(2) Herb Gynostemmae Pentaphylli, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Cortex Cinnamomi, Fructus Corni, Fructus Momordicae water intaking decocting liquid concentrate, and obtain water extracting liquid;

(3) get Radix Et Caulis Acanthopanacis Senticosi and extract with alcoholic solution, removing slag to extract concentrates, and obtains the alcohol extraction concentrated solution;

(4) get Radix Salviae Miltiorrhizae drying and crushing to 60 order coarse powder;

(5) concentrated solution of the concentrated solution of step (2), step (3) and Radix Salviae Miltiorrhizae are mixed after again spray drying, granulating to form makes former medicine dry powder;

(6) former medicine dry powder is added the granulation of equivalent dextrin and form finished product.