CN102277288A - Health wine and preparation method thereof - Google Patents
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Abstract
Based on Chinese traditional medical theory and modern research method of science of Chinese pharmacology, a Chinese medicinal formula for health wine having the functions of anti-oxidation, anti-fatigue and improvement to immunity and having little harm to liver is provided in the invention. The health wine is prepared by soaking bulk drugs and filtering the bulk drugs, wherein, the bulk drugs comprise, by weight, 0.2 part to 2 parts of gen-seng, 0.1 to 1 part of hippocampus, 0.3 part to 3 parts of pseudo-ginseng, 0.1 to 1 part of root of kudzu vine, 0.1 to 1 part of hovenia dulcis thunb, 0.1 to 1 part of rhodiola root and 0.1 to 1 part of mythic fungus powder, with the balance being distilled liquor. The health wine has the advantages of nontoxicity and low cost, is convenient to prepare, and has a good effect in the aspects like improving blood circulation by reducing blood fat, invigorating blood circulation, smoothing vein, etc. The health wine prepared by the formula provided in the invention definitely has a good market prospect.
Description
Technical field
The present invention relates to a kind of health promoting wine and preparation method thereof, particularly a kind of have antifatigue and little to liver injury, that toxicity is little health promoting wine and preparation method thereof.
Background technology
Liquor historical of long standing and well established is that people entertain, one of important drink when celebrating.The ethanol content of liquor is higher, and other nutritive substance relative content is lower, and is little to the human body benefit after drinking.Along with the progress of society, the improving constantly of people's living standard, idea is also being brought in constant renewal in, and when requiring to drink, can not only enjoy drink happy, and will guarantee healthy.At present, the number of drinking white spirit is accustomed to for a long time up to more than one hundred million by China.In this colony, alcohol abuse and alcohol dependence have become public health problem serious day by day in the world today, not only cause various criminal offenses, traffic accident, unexpected injury etc., and have a strong impact on healthy.Alcoholic liver disease (ALD) is because the toxic liver injury that long-term heavy drinking causes.Alcohol user male sex's amount of alcohol 40g/d, women's amount of alcohol 20g/d was above 5 years; Or 2 have crapulence history (amount of alcohol＞80g/d) can cause ALD in week.Ethanol is the major cause that causes alcoholic liver injury at the toxic metabolite of liver cell intracellular metabolite generation and the metabolism disorder that causes thereof.ALD is divided into: alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis.ALD is the main cause of disease that western countries cause liver cirrhosis, in countries in Asia's (comprising China), although the various hepatopathys due to the viral hepatitis in the highest flight, but increase along with the drinks consumption, the change of people's dietary structure, also be ascendant trend year by year by the hepatic injury due to the alcohol in recent years, alcohol has become the second largest cause of disease that causes hepatic injury after viral hepatitis.Therefore, to the research of ALD and how to prevent and treat the focus that alcoholic liver injury has become medical circle research.
The promptly middle medical drugs of Chinese medicine is the peculiar medicine of the traditional traditional Chinese medical science of China.Chinese medicine is divided into Chinese patent medicine, Chinese medicinal materials by complete processing.At present, the herbal medicine with anti-oxidant, antifatigue, raising immunizing power and liver protecting of development pure natural is the effective way of prevention and treatment liver injury.Chinese medicine compound prescription be meant dialectical examine because of the decision therapy after, select suitable medicine to decide consumption, the one group of medicine that forms according to the appropriate compatibility of composing principle. its contained complex chemical composition, pharmacological action have the multi-level characteristics of many target spots.People constantly seek antifatigue and the little medicine of liver injury are prevented alcoholic liver injury for a long time.Comparatively speaking, herbal medicine and the health promoting wine thereof with anti-oxidant, antifatigue, raising immunizing power and liver protecting studies show that out certain advantage.Therefore, dissolving in the traditional Chinese medicine ingredients with different health-care effecies in wine, in order to prevent and to reduce the damage of alcohol to liver, have expectation antifatigue and the effect little to liver injury simultaneously, is a kind of ideal developing direction.
Yet the traditional Chinese medical science is thought " three fens poison of all medicines, nontoxic not patent medicine ".The toxicity of Chinese medicine and side effect, i.e. the untoward reaction of Chinese medicine, it is produced simultaneously to the treatment disease independent and to the more deleterious effects of body to be that Chinese medicine is accompanied by the therapeutic action of Chinese medicine when acting on body.Have only and fully understood the factor that influences herbal toxic effect, many-sided allotment in preparation medicine process could reduce the untoward reaction of product.Bibliographical information, the toxic side effect of Chinese medicine mainly come from following some:
(1) oneself factor of Chinese medicine
Usually Effective Components of Chinese Herb also is a toxic component simultaneously, as the vauqueline in the nux vomica, and the napelline in the Radix Aconiti, the arsenic oxide arsenoxide in the arsenolite etc.Therefore proper with it, can cure the disease, improper use then not only can not be cured the disease, and causes that on the contrary the body negative and positive of qi and blood lacks of proper care and cause a disease.
(2) place of production factor when adopting
The Tang Dynasty " Xinxiu Bencao " has carries: " from its native country, then matter is with effectively different, well-behaved in harvesting, is that thing is and real non-".Some medicinal material place of production difference is described, quality is promptly different, and collecting season is not right, and pharmaceutical use has just differed widely, and also can increase the weight of the toxicity, side effect of medicine sometimes.Produce the matter optimum as wolfberry fruit with Ningxia, and the wolfberry fruit that east, Hebei deer produces, because of the lead tolerance height can not be medicinal.
(4) factor of the process of preparing Chinese medicine and preparation
Chinese medicine preparation is the important component part in motherland's medicine and pharmacology legacy, then is ancient Chinese medicine doctor exactissima diligentia and attention to the toxic process of preparing Chinese medicine.If toxic traditional Chinese medicine does not only reach the purpose of clinical treatment, but also may cause poisoning even threat to life improper without concocting and concocting.There is heating to concoct, add the auxiliary material process of preparing Chinese medicine, the water treatment process of preparing Chinese medicine, method of making drugs into frostlike powder by concocting the method that reduces or eliminate untoward reaction.
(5) factor of combination drug
Compatibility is the basic form of middle medical drugs.The compatibility of Chinese medicine just spells out in Shennong's Herbal: " when good, do not use mutual inhibition opposite with mutual reinforcement between phase envoy, if poisonous should the system, available mutual restraint between two drugs phase senilicide, you do not share yet." that is to say the medicine compatibility method that should utilize the mutual reinforcement between mutual-assistance, the coordinative role of performance medicine will be with the medicine compatibility method of making mutually, to make its toxic side effect to toxic medicament.
Chinese patent application CN200710010529.1 provides a kind of " health promoting wine of antifatigue, adjusting and enhancing body immunologic function ", and this health promoting wine contains 32 kinds of medicinal materials such as wrinkled giant hyssop, eupatorium, Poria cocos, has the effect of certain antifatigue.But have also that composition is too much, cost is too high, be difficult to the defective for preparing simultaneously.Simultaneously, because the medicinal material that relates to is too much, excessive to drink this health promoting wine also unknown to the influence of liver injury.
Chinese patent application CN 201010142447.4 provides a kind of " a kind of raising man sexual function and antifatigue nutrient health care wine and preparation method thereof ", this health promoting wine composition is simple, based on Semen Phaseoli, wolfberry fruit, Chinese yam, sophora flower Chinese medicinal materials, has the effect of certain antifatigue.But this health promoting wine is mainly used in and improves the adult man sexual function, and excessive to drink this health promoting wine also unknown to the influence of liver injury.
Therefore, need a kind of new type health-care liquor at present, this health promoting wine can antifatigue, improve physical qualification, can be convenient to preparation and with low cost again, and the while can effectively be brought into play the health active of each composition, and the toxicity that can effectively reduce traditional Chinese medicine ingredients and join wine.
Summary of the invention
It is that starting point is carried out compatibility that the principle of the invention is with the traditional Chinese medicine theory, carry out the enrichment of active principle biological extraction with the modern pharmacology method again, finally investigate the drug effect and the toxicity of prescription, finally obtain a kind of have anti-oxidant, antifatigue, raising immunizing power and the health promoting wine compound little liver injury with modern pharmacology, toxicologic study mode.This compound is a raw material with the integration of drinking and medicinal herbs Chinese medicinal materials of State Food and Drug Administration's defined, consults traditional Chinese medical science pharmacopeia simultaneously, otherwise this prescription does not have mutual restraint between two drugs medicinal material mutually.Main prescription comprises: genseng, hippocampus, pseudo-ginseng, trifoliate orange seed, the root of kudzu vine, Root of Kirilow Rhodiola and Ganoderma powder.
In addition, the invention provides the Production of Healthy Wine method, the health promoting wine that this method is common with respect to existing market is that extraction biological activity elite technology combines with traditional assembled alcoholic drinks technology, also is the practical application of low-carbon (LC) science and technology.
Therefore, the present invention's first purpose provides a kind ofly has anti-oxidant, antifatigue, raising immunizing power and to the composite side of Chinese medicinal materials of the little health promoting wine of liver injury,
In one embodiment, health promoting wine is bulk drug to be refiltered make behind the steeping in wine bubble, wherein each material composition is formed with following weight part: 0.2～2 part of genseng, 0.1～1 part of hippocampus, 0.3～3 part of pseudo-ginseng, 0.1～1 part of the root of kudzu vine, 0.1～1 part of trifoliate orange seed, 0.1～1 part of Root of Kirilow Rhodiola, 0.1～1 part of Ganoderma powder, all the other are an amount of liquor.
In a specific embodiments, each material composition is formed with following weight part: 1 part of genseng, 1 part of hippocampus, 2 parts of pseudo-ginseng, 0.5 part of the root of kudzu vine, 0.5 part of trifoliate orange seed, 0.5 part of Root of Kirilow Rhodiola, 0.2 part of Ganoderma powder, all the other are an amount of liquor.
In another embodiment, each material composition is formed with following weight part: 1 part of genseng, 0.5 part of hippocampus, 3 parts of pseudo-ginseng, 0.5 part of the root of kudzu vine, 0.5 part of trifoliate orange Dulcis, 0.5 part of Root of Kirilow Rhodiola, 0.25 part of Ganoderma powder, all the other are an amount of liquor.
Second purpose of the present invention provides the preparation method of above-mentioned health promoting wine, and step comprises:
1) with aforementioned proportion genseng, hippocampus, add 15～25% liquor diluents and a small amount of fishy-smell removing agent in 5～35 ℃ of following supersound extraction 60～100min, and repeat twice, merging filtrate is stand-by.
2) pseudo-ginseng, trifoliate orange seed, the root of kudzu vine, Root of Kirilow Rhodiola are added 5-20 according to the above ratio and doubly measure liquor, soaked 20～30 days at 5～35 ℃, repeat twice, merging filtrate is stand-by.
3) according to the above ratio each filtrate is mixed, be about 30～45 ℃, add 5 times of scattered Ganoderma powder of amount of liquor diluent more in proportion, obtain work in-process with 15～30% with liquor and pure water modulation alcoholic strength;
4) work in-process are mixed colours, acid adjustment, seasoning;
5) ageing, degerming, bottling.
In one embodiment, wherein step 4 comprises with chrysanthemum, Japanese Honeysuckle, Citric Acid toning, acid adjustment, seasoning.
In another embodiment, wherein step 5 comprises health promoting wine work in-process lucifuge, subzero 4 ℃～10 ℃ of ageings above freezing of low temperature 6～12 months, behind the smart filtering bacterium, and last production line bottling.
Also in other embodiments, in wherein above-mentioned arbitrary scheme, wherein liquor comprises rice wine, coarse cereals wine, Kaoliang spirit, whisky, brandy.
Chinese medicine preparation
Genseng, per nnial herb, property is flat, sweet, the little hardship of flavor, tepor; Return spleen, lung channel.Kind of ginsenoside isolate 30 altogether from genseng surplus (can be divided into three groups, be Oleanolic Acid group, protopanoxadiol group and Protopanaxatriol's group), be called ginsenoside (Ginsenoside)-RX (annotating: X=0, a1, a2, a3, b1, b2, b3, c, d, e, f, g1, g2, g3, h1, h2, h3, s1, s2), panicled fameflower root saponin (Pseudoginsenoside saponin) F11 etc. is still arranged.Saponin is the basic substance of genseng physiologically active, and its pharmacological action is very extensive: genseng has antifatigue effect, and its mechanism may and promote protein, RNA to synthesize relevant with the rising blood fat.The antifatigue effect that studies show that the ginsenoside Rg1 is remarkable, the no antifatigue effect of neutral saponin (Rb1, Rb2, Rc etc.).Isolate the lipotropic component that is left behind the ginsenoside, also can increase the autonomic movement of mouse, show antifatigue effect.Genseng can make the availability of glycogen, energy-rich phosphate more economical, prevents the accumulation of lactic acid and pyruvic acid, and makes its metabolism more complete.Genseng also can stop in the tissue that the rat prolonged exercise causes in the glycogen and suprarenal gland cholesterol to be exhausted.Genseng can increase the enzymic activity of each material of liver metabolism, the detoxification ability of liver is strengthened, thereby enhancing body is to the tolerance of various chemical substances.Experiment shows: genseng can increase the activity of ethanol dehydrogenase in the liver, can shorten the anesthesia duration of ethanol to rabbit and dog, makes the very fast reduction of ethanol level in the rabbit blood.There is report to point out that genseng can strengthen the function of detoxification of liver, the effect of anti-liver injury is also arranged.The Herba Herminii saponin has the effect of alleviating to the liver injury transaminase mass formed by blood stasis that tetracol phenixin causes.Report is also arranged, and the ginsenoside decapacitation reduces tetracol phenixin and causes outside the active rising of rabbit anteserum glutamic-oxal(o)acetic transaminase, to other poisonous substances, causes the variation of rabbit hepatic tissue as thioacetamide, and ginsenoside also can make it to alleviate.The anti-liver toxicity of ginsenoside and the result of study of some structure-effect relation are found the anti-liver cytotoxic activity that red ginseng is stronger than Bai Canyou probably.Genseng is fairly obvious to the alcoholic acid detoxification; it can not only shorten the time length of ethanol anesthesia and accelerate to recover the normal time; can also reduce GOT in the serum, GPT, ALP and bilirubin equal size; and can increase the activity of alcoholdehydrogenase and the aldehyde dehydrogenase relevant with alcohol metabolism; simultaneously the toxic substance acetaldehyde that alcohol metabolism produced is promptly excreted, thereby also because excessive hydrogen participates in the synthetic liver of protecting ethylism effectively of saponin.
Hippocampus (sea horse) net-rope, the sea otter order, the general name of Hippocampus animal belongs to bony fish.Sweet in flavor and warm in property, traditional Chinese medical science Shanghai saddlery has kidney invigorating and YANG supporting, the effect of eliminating mass lump in the abdomen, and modern study confirms that hippocampus contains amino acid and protein, lipid acid, steroidal and inorganic elements.Hippocampus trimaculatus Leacs contains stearic acid, cholesterol, the solid glycol of courage etc.; Strain line hippocampus and HIPPOCAMPUS still contain acetylcholinesterase, cholinesterase, proteolytic enzyme.The ethanol extraction of hippocampus (i.e. " Hippocampus japonicus liquor ") can bring out and prolong the oestrus of female mice, and the weight of uterus and ovary is increased, and the weight of male mouse prostate gland, seminal vesicle, levator ani is obviously increased, and shows as androgen-like action.Hippocampus can strengthen the mouse hypoxia tolerance, reduces the activity of monoamine oxidase, reduces lipid peroxidation body content in vivo.In addition, various Hippocampus extracts all have the effect of calcium channel blocker.By flowing in the blocking-up calcium, reach the effect of neuroprotective unit.The hippocampus fecund in Guangdong, coastland such as Fujian, Taiwan.Summer, autumn fish for, and clean, or remove internal organ, epithelium, dry.Smash more or grind into powder usefulness to pieces.Belong to national second class protection animal now, can manually culture.
Pseudo-ginseng has another name called pseudo-ginseng, and the famous pharmacy man LI Shi-Zhen of the Ming Dynasty is called " invaluable ".Sweet and slightly bitter taste, property is flat, and is nontoxic.Put down in writing in Qing Dynasty's pharmacy works supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, pseudo-ginseng enrich blood the first, the flavor with and merit also waits, so the title Panax pseudoginseng, be the most precious person in the Chinese medicine." become famous Chinese patent medicine " Yunnan white powder " at home and abroad and " sheet is young yellow ", promptly be that main raw material is made with the pseudo-ginseng.Pseudo-ginseng has the anti-liver injury effect, can significantly reduce carbon tetrachloride hepatic injury mice serum ALT activity.The pseudo-ginseng methanol extract can significantly reduce AST and serum lactic dehydrogenase (LDH) activity in the rat blood serum to the rats'liver damage that tetracol phenixin, D one semi-lactosi amine cause, the hepatocellular degeneration necrosis is alleviated.Pseudo-ginseng also has anti hepatic fibrosis, to the damage of N-nitrosodimethylamine poisoning rats'liver, treats for 4 weeks with Radix Notoginseng powder, and the hepatocellular degeneration necrosis is alleviated, and collegen filament reduce between liver cell.To the carbon tetrachloride poisoning hepatic fibrosis rats, when giving the tetracol phenixin moulding, oral Radix Notoginseng powder prevented and treated for 9 weeks, can alleviate liver fat sex change, inflammatory cell infiltration, hepatocellular degeneration necrosis.Be reduced to the hyperplasia of fibrocyte and collagen.Pseudo-ginseng has certain choleretic effect, and Radix Notoginseng injection has remarkable reduction serum bilirubin to the rabbit liver internal congestion jaundice that the a-Yi Liuqingsuannaizhi causes, promotes the choleresis effect.Pseudo-ginseng promotes hepatic protein synthetic, increases the mix speed of 3H-TdR to impaired liver dna, increases the mix speed of 3H-leucine to hepatic protein.
Trifoliate orange seed, sweet, the property of distinguishing the flavor of is flat; Nourishing the liver, nourshing kidney, moistening lung.The traditional Chinese medical science usually with it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, illness such as seminal emission.Modern study, trifoliate orange seed has lowering blood glucose, lipotropy, and can atherosclerosis.Modern medicine study confirms that it contains nutritive ingredients such as betaine, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamins C, VITMAIN B1, Wei ShengsuB2 and calcium, phosphorus, iron, zinc, manganese, linolic acid, hemopoietic function there is promoter action, can also be anti-ageing, anti-mutation, antitumor, anti-fatty liveranti-fatty liver and effect such as hypoglycemic.
The root of kudzu vine, cool in nature, it is sweet, hot to distinguish the flavor of.Being legume pueraria lobata, is a kind of normal food vegetables of some provinces and regions of southern china, and its sweet cold of distinguishing the flavor of is good to eat, often makes the usefulness of Baoshang.Its main component is a starch, contains 12% the flavonoid compound of having an appointment in addition, comprises kind surplus soybean (soya bean) glucoside, daidzein, the puerarin etc. 10; And contain daucosterol, amino acid, coumarins etc.Can be used as medicinal application.The famous physician's LI Shi-Zhen of the Ming Dynasty has been carried out systematic research to the root of kudzu vine, think the stem, leaf, flower of the root of kudzu vine, really, root all can be used as medicine.He is record like this in Compendium of Material Medica: " Pueraria lobota, property is sweet, hot, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all frauds, a cloudy gas is separated all poison ".The root of kudzu vine has following action and efficacy: improve hepatocellular regenerative power, recover the normal liver function, promote choleresis, prevent that fat from piling up at liver.Enhance metabolism, strengthen liver detoxification function, prevent the damage of alcohol liver.To the coronary sclerosis that hyperlipidemia forms,, prevent and treat cardiovascular disordeies such as coronary heart disease, stenocardia, myocardial infarction by improving myocardial ischemia.Cerebral arteriosclerosis to hyperlipidemia forms by improving cerebral ischemic condition, prevents and treats cerebrovascular diseases such as cerebral infarction, hemiplegia, vascular dementia.Change liver and gall cell autoimmune function, the opposing poisoning intrusion.
Root of Kirilow Rhodiola, perennial herb, property is sweet, and hardship is flat.Return lung, the heart channel of Hang-Shaoyin.Root of Kirilow Rhodiola is the special articles for use of physical culture always, can promote or keep the endurance of sportsmen in match or training period.Experimentation on animals proves, after mouse is taken Radix Rhodiolae extract, can obviously prolong long-distance swimming time, the synthetic or resynthesis of adenosine triphosphate (ATP) in the plastosome in the irritation cell.This high energy molecule synthesis is exactly the main energy source of most cells function, also be the motion and breathe obligato.Research points out that oxygenizement in a lot of advancing of disease processes, playing the part of crucial role, for example cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Root of Kirilow Rhodiola also is used for treating diabetes.Relevant experiment utilizes mouse to make object, and the test Root of Kirilow Rhodiola is to glycemic index, ferment and some oxidation resistant activities of control type-II diabetes.Experiment shows Radix Rhodiolae extract reducing blood glucose effectively, quickens anti-oxidant activity.The prompting Root of Kirilow Rhodiola may have certain effectiveness to prevention hyperglycemia illness.Clinical showing, Root of Kirilow Rhodiola can obviously resist pneumonia and asthma.Effective to allergic asthma, general adult looks the state of an illness needs to restrain with 15---30 every day, is decocted in water for oral dose, and 1 course of treatment of first quarter moon, can increase the course of treatment according to need.
The main component of Ganoderma powder is ganoderan, Ganodenic acid, adenosine and more than 10 kind of alkali, oleic acid, Mierocrystalline cellulose, amino acid, trace element etc., and its range of application is very extensive, to the heart, lung, liver,spleen,kidney are dirty etc. medical functions is arranged all.Ganoderma powder is medicinal material still not, also is top grade food, and property is flat, has no side effect, and is all-ages, and pregnant woman and child are many to take after mixing it with water with Ganoderma powder, can play the effect of good adjusting immunizing power, and the generation of prevention various diseases is avoided having an injection and taken medicine; The elderly takes, and has the effect of two-ways regulation blood pressure, prevents various cancers simultaneously; For the people of allergic constitution, often eat the effect that a little Ganoderma powder can play certain Ammonium Glycyrrhizate; When selecting Ganoderma powder, should pay the utmost attention to " Ganoderma sinense Zhao, Xu et Zhang ", this is the drug effect the best because of " Ganoderma sinense Zhao, Xu et Zhang ", nutritive value is the highest.
Beneficial effect
The present invention is directed to that each Chinese medicinal materials has all been done detailed experimental study and document is solved, belong to the integration of drinking and medicinal herbs material basically, and theory of traditional Chinese medical science is investigated no incompatibility; But, can not guarantee that in biomagnification and hybrid modulation process its chemical ingredients does not interact because its every kind contained chemical ingredients of medicinal material is various.So, done further toxicology and pharmacological experiment, find that the activeconstituents of this composite biological extraction is nontoxic, have assisting therapy fatiguability and hypoimmunity simultaneously, solve the subhealth state problem.The health promoting wine made from this prescription will have good market outlook.
In addition, advantage compared with prior art of the present invention is: prepare 1, that its active component raw material is natural, material combination rationally and science; 2, based on strong liver kidney tonifying, the mediation the five internal organs, qi-blood tonifying, promote to recover physiological function, have nourishing functions such as antifatigue, immunomodulatory; 3, production process is simple, has reduced production cost, is fit to the large-scale production needs.
Embodiment:
Further illustrate the present invention in the following embodiments, this does not limit the scope of the invention.
Embodiment 1
Get 5kg genseng, 5kg hippocampus powder, add 35% rice wine diluent 200kg, 25 ℃ of following supersound extraction 30min, and repeat twice, merging filtrate, A filtrate is stand-by.
Get 1 kilogram of trifoliate orange seed 2.5kg, root of kudzu vine 2.5kg, pseudo-ginseng 10kg and Ganoderma powder, pulverize at low temperature adds 150kg rice wine (60 degree), soaks 20 days at 25 ℃, repeats twice, merging filtrate, B filtrate is stand-by.
A, B filtrate are mixed, be about 45 degree, add in proportion again with 30% rice wine diluent 25kg and scattered Root of Kirilow Rhodiola 2.5kg with rice wine and pure water modulation alcoholic strength.Again with chrysanthemum, Japanese Honeysuckle, Citric Acid toning, acid adjustment, seasoning, lucifuge, subzero 4 ℃ were placed 6 months, and behind the smart filtering bacterium, last production line is bottled.
Embodiment 2
Get 2kg genseng, 1kg hippocampus powder, add 10kg 35% whisky diluent 50kg, 5 ℃ of following supersound extraction 30min, and repeat twice, merging filtrate, A filtrate is stand-by.
Get 0.5 kilogram of trifoliate orange seed 1kg, root of kudzu vine 1kg, pseudo-ginseng 6kg and Ganoderma powder, normal temperature is pulverized, and adds 150kg whisky (40 degree), soaks 30 days at 15 ℃, repeats twice, merging filtrate, B filtrate is stand-by.
A, B filtrate are mixed, be about 38, add in proportion again with 30% whisky diluent 25kg and scattered Root of Kirilow Rhodiola 1kg with whisky and pure water modulation alcoholic strength.Again with chrysanthemum, Japanese Honeysuckle, Citric Acid toning, acid adjustment, seasoning, lucifuge, subzero 4 ℃ were placed 3 months, and behind the smart filtering bacterium, last production line is bottled.
The experiment that embodiment 3 health promoting wine toxicity are little, little to liver injury-mouse multiple dosing mtd test
Experimental data all adopts Microsoft Excel2000 to carry out statistical procedures on PC, and the result represents with xs, and carries out TTEST and analyze the significance of t value method comparative group differences.
(SPF level laboratory animal, Guangdong Medical Lab Animal Center provides, credit number: SYXK (Guangdong) 2008-0002 to choose healthy NIH mouse.), male and female are regardless of, and body weight 18-23g is divided into 3 groups at random, is respectively 5 groups in blank group, 1 group in sample and sample, every group of 15 mouse.Mouse fasting 24h before the experiment, the body weight of a mouse of record; When beginning experiment, each is organized mouse and gives the peak concentration of given the test agent by the 0.2ml/10g body weight, whole day administration 4 times altogether, each 2 hours at interval.Observed 7 days continuously after the administration, whether the observation mouse spirit occurred, activity, diet abnormal conditions and death condition in 7 days.For the mouse of the death anatomic observation heart immediately, liver, spleen, lung, kidney etc., record pathology situation.In 8d each group mouse is write down body weight, comparative group differences; Put to death whole mouse then, vitals are observed, record pathology situation.
Table 1 mouse is maximal dose administration front and back body weight change list repeatedly
| The 1st day | The 2nd day | The 3rd day | The 4th day | The 5th day | The 6th day | The 7th day | |
| 1 group in sample | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 groups in sample | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Phenomenon | No abnormal | No abnormal | No abnormal | No abnormal | No abnormal | No abnormal | No abnormal |
Observe the 7d experimental record behind table 2 multiple dosing continuously
The result is shown in table 1 and 2: the mouse whole day gives the peak concentration of 4 given the test agent, and it is dead not see that mouse occurs, and the mouse hair color is bright and clean, the activity normal, diet is normal; Observed 7 days continuously after the administration, it is active that each organizes mouse spirit, movable normal, ingests and drink water normally, and do not see that death condition takes place.Each organizes that body weight before and after the mouse administration and observations see Table 3 respectively, shown in the table 4, being tried polysaccharide does not have significantly the body weight of mouse and influences, after experiment finishes, put to death all mouse, naked eyes comprise that to important organ the heart, liver, spleen, lung, kidney, brain etc. check, do not find tangible organic disease; Point out thus under predose, given the test agent is not seen the overt toxicity reaction.
The experimental observation of embodiment 4 health promoting wine antifatigues
In order to prove the nourishing and health preserving effect of product of the present invention, choose the adult human consumer that surpass 3 years 100 wine storage time, wherein the mean age surpasses 35 years old, is equally divided into 2 groups (50 people/groups).Allow their each cuvette, each 30-50ml, noon and evening each once, also can increase the amount of drinking slightly according to the capacity for liquor of oneself, be as the criterion up to taking effect, during no longer drink other liquor.Control group is then drunk conventional liquor.
After drinking January, detect by following index: (1) is standard effectively: the spiritlessness and weakness sense is eliminated, and energetic have a vigor, has rosy cheeks, and appetite strengthens, and is clearheaded, thought active, and study and work has passion, improved efficiency; Energetic, sleep soundly, happy, physique obviously strengthens, and health stimulates (cold and hot) resistivity to strengthen to external world, and the organism fatigue time is delayed.(2) invalid standard: above phenomenon obviously do not occur.
Table 3 nutrition is with regard to the experimental observation of antifatigue
Viewing duration meets 42 people of above-mentioned effective standard by statistics, efficiently reaches 84%.In drinking process, find no untoward reaction, safe for drinking.And effective 6 examples of control group account for 12%, and invalid 44 examples account for 88%.Although control group is not drunk health promoting wine, but test result shows the phenomenon that also has certain antifatigue, this may be in test process, the human consumer had controlled capacity for liquor relatively in the past greatly, simultaneously also positive adjustment work and rest is accustomed to and is paid attention to other health care modes, therefore also can have the effect of certain antifatigue.If this yet can not pay attention to adjusting living habit and strengthen exercise in the fine explanation health promoting wine group, equally also invalid result can appear.In a word, compare with control group, drink health promoting wine of the present invention, its total effectively example reaches 84%, considerably beyond 12% of control group.
Claims (7)
1. health promoting wine, be bulk drug to be refiltered make behind the steeping in wine bubble, wherein each material composition is formed with following weight part: 0.2～2 part of genseng, 0.1～1 part of hippocampus, 0.3～3 part of pseudo-ginseng, 0.1～1 part of the root of kudzu vine, 0.1～1 part of trifoliate orange seed, 0.1～1 part of Root of Kirilow Rhodiola, 0.1～1 part of Ganoderma powder, all the other are an amount of liquor.
2. the health promoting wine of claim 1, wherein each material composition is formed with following weight part: 1 part of genseng, 1 part of hippocampus, 2 parts of pseudo-ginseng, 0.5 part of the root of kudzu vine, 0.5 part of trifoliate orange seed, 0.5 part of Root of Kirilow Rhodiola, 0.2 part of Ganoderma powder, all the other are an amount of liquor.
3. claim 1 and 2 health promoting wine, wherein each material composition is formed with following weight part: 1 part of genseng, 0.5 part of hippocampus, 3 parts of pseudo-ginseng, 0.5 part of the root of kudzu vine, 0.5 part of trifoliate orange Dulcis, 0.5 part of Root of Kirilow Rhodiola, 0.25 part of Ganoderma powder, all the other are an amount of liquor.
4. the preparation method of the health promoting wine of claim 1-3, its step comprises:
1) with aforementioned proportion genseng, hippocampus, add 15～25% liquor diluents and a small amount of fishy-smell removing agent in 5～35 ℃ of following supersound extraction 60～100min, and repeat twice, merging filtrate is stand-by.
2) pseudo-ginseng, trifoliate orange seed, the root of kudzu vine, Root of Kirilow Rhodiola are added 5-20 according to the above ratio and doubly measure liquor, soaked 20～30 days at 5～35 ℃, repeat twice, merging filtrate is stand-by.
3) according to the above ratio each filtrate is mixed, be about 30～45 ℃, add 5 times of scattered Ganoderma powder of amount of liquor diluent more in proportion, obtain work in-process with 15～30% with liquor and pure water modulation alcoholic strength;
4) work in-process are mixed colours, acid adjustment, seasoning;
5) ageing, degerming, bottling.
5. the method for claim 4, wherein step 4 comprises with chrysanthemum, Japanese Honeysuckle, Citric Acid toning, acid adjustment, seasoning.
6. claim 4 and 5 method, wherein step 5 comprises health promoting wine work in-process lucifuge, subzero 4 ℃～10 ℃ of ageings above freezing of low temperature 6～12 months, behind the smart filtering bacterium, last production line bottling.
7. the method for claim 4-6, in wherein above-mentioned arbitrary scheme, wherein liquor comprises rice wine, coarse cereals wine, Kaoliang spirit, whisky, brandy.
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| CN104673611A (en) * | 2015-03-25 | 2015-06-03 | 泸州品创科技有限公司 | Rose steeped wine and preparation method thereof |
| CN104694356A (en) * | 2015-03-20 | 2015-06-10 | 吉林大学 | Ginseng liver protection health care wine and making method thereof |
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